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Table of Contents

November 24, 2015; vol. 112 no. 47

This Week in PNAS

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    In This Issue
    PNAS November 24, 2015 112 (47) 14397-14398; https://doi.org/10.1073/iti4715112

Letters (Online Only)

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    Genetics of alcohol use disorders: Actin gets into the act
    Golo Kronenberg, Matthias Endres, and Karen Gertz
    PNAS November 24, 2015 112 (47) E6411; first published October 29, 2015. https://doi.org/10.1073/pnas.1514716112
  • You have access
    Distinguishing phases of biomedical research is critical to improving health outcomes
    Kevin Fiscella
    PNAS November 24, 2015 112 (47) E6412; first published November 10, 2015. https://doi.org/10.1073/pnas.1518862112
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    Reply to Fiscella: The phases of biomedical research should be studied to optimize health outcomes
    Anthony Bowen and Arturo Casadevall
    PNAS November 24, 2015 112 (47) E6413; first published November 10, 2015. https://doi.org/10.1073/pnas.1519759112

    See companion article:

    • Input-outcome disparities in biomedical research
      - Aug 17, 2015
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    Vaginal microbiota during pregnancy: Pathways of risk of preterm delivery in the absence of intrauterine infection?
    Jeffrey A. Keelan and Matthew S. Payne
    PNAS November 24, 2015 112 (47) E6414; first published October 29, 2015. https://doi.org/10.1073/pnas.1517346112
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    Reply to Keelan and Payne: Microbiota-related pathways for preterm birth
    Daniel B. DiGiulio, David K. Stevenson, Gary Shaw, Deirdre J. Lyell, and David A. Relman
    PNAS November 24, 2015 112 (47) E6415; first published October 29, 2015. https://doi.org/10.1073/pnas.1517939112

    See companion article:

    • Microbiota during pregnancy
      - Aug 17, 2015

News Feature

An in-depth look at trending science issues.
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    News Feature: How online studies are transforming psychology research
    • Front Matter
    Amber Dance
    PNAS November 24, 2015 112 (47) 14399-14401; https://doi.org/10.1073/pnas.1520769112

Commentaries

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    Managing variance: Key policy challenges for the Anthropocene
    John M. Anderies
    PNAS November 24, 2015 112 (47) 14402-14403; first published November 17, 2015. https://doi.org/10.1073/pnas.1519071112

    See companion article:

    • Variance and fragility of ecosystems
      - Oct 05, 2015
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    Predictive model of 3D domain formation via CTCF-mediated extrusion
    Galip Gürkan Yardımcı and William Stafford Noble
    PNAS November 24, 2015 112 (47) 14404-14405; first published November 13, 2015. https://doi.org/10.1073/pnas.1519849112

    See companion article:

    • Extrusion predicts 3D genome engineering results
      - Oct 23, 2015
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    Advanced neuroendocrine prostate tumors regress to stemness
    Leigh Ellis and Massimo Loda
    PNAS November 24, 2015 112 (47) 14406-14407; first published November 17, 2015. https://doi.org/10.1073/pnas.1519151112

    See companion article:

    • Stem cell signature in aggressive prostate cancer
      - Oct 12, 2015
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    Imprinted X chromosome inactivation offers up a double dose of epigenetics
    Nora Engel
    PNAS November 24, 2015 112 (47) 14408-14409; first published November 17, 2015. https://doi.org/10.1073/pnas.1520097112

    See companion article:

    • Xist imprinting by the unpaired state
      - Oct 21, 2015
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    Penciling in details of the Hadean
    Christopher H. House
    PNAS November 24, 2015 112 (47) 14410-14411; first published November 12, 2015. https://doi.org/10.1073/pnas.1519765112

    See companion article:

    • Potentially biogenic 4.1 billion-year-old carbon
      - Oct 19, 2015

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS November 24, 2015 112 (47) 14412-14414; https://doi.org/10.1073/pnas.ss11247

The Engineering of Biology and Medicine PNAS 100th Anniversary Special Feature (Free Online)

  • Introduction

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      The Engineering of Biology and Medicine
      • From the Cover
      Mark E. Davis and Robert Langer
      PNAS November 24, 2015 112 (47) 14423; first published November 23, 2015. https://doi.org/10.1073/pnas.1517450112
  • Perspectives

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      Advancing biomedical imaging
      Ralph Weissleder and Matthias Nahrendorf
      PNAS November 24, 2015 112 (47) 14424-14428; first published November 23, 2015. https://doi.org/10.1073/pnas.1508524112
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      Synthetic biology devices for in vitro and in vivo diagnostics
      Shimyn Slomovic, Keith Pardee, and James J. Collins
      PNAS November 24, 2015 112 (47) 14429-14435; first published November 23, 2015. https://doi.org/10.1073/pnas.1508521112
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      Nanotechnologies for biomedical science and translational medicine
      James R. Heath
      PNAS November 24, 2015 112 (47) 14436-14443; first published November 23, 2015. https://doi.org/10.1073/pnas.1515202112
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      Progress in material design for biomedical applications
      Mark W. Tibbitt, Christopher B. Rodell, Jason A. Burdick, and Kristi S. Anseth
      PNAS November 24, 2015 112 (47) 14444-14451; first published November 23, 2015. https://doi.org/10.1073/pnas.1516247112
    • You have access
      Regenerative medicine: Current therapies and future directions
      Angelo S. Mao and David J. Mooney
      PNAS November 24, 2015 112 (47) 14452-14459; first published November 23, 2015. https://doi.org/10.1073/pnas.1508520112
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      Smart nanosystems: Bio-inspired technologies that interact with the host environment
      Ester J. Kwon, Justin H. Lo, and Sangeeta N. Bhatia
      PNAS November 24, 2015 112 (47) 14460-14466; first published November 23, 2015. https://doi.org/10.1073/pnas.1508522112
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      Engineering opportunities in cancer immunotherapy
      Laura Jeanbart and Melody A. Swartz
      PNAS November 24, 2015 112 (47) 14467-14472; first published November 23, 2015. https://doi.org/10.1073/pnas.1508516112

Physical Sciences

  • Applied Mathematics

    • Open Access
      Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
      Adrian L. Sanborn, Suhas S. P. Rao, Su-Chen Huang, Neva C. Durand, Miriam H. Huntley, Andrew I. Jewett, Ivan D. Bochkov, Dharmaraj Chinnappan, Ashok Cutkosky, Jian Li, Kristopher P. Geeting, Andreas Gnirke, Alexandre Melnikov, Doug McKenna, Elena K. Stamenova, Eric S. Lander, and Erez Lieberman Aiden
      PNAS November 24, 2015 112 (47) E6456-E6465; first published October 23, 2015. https://doi.org/10.1073/pnas.1518552112

      See companion article:

      • DNA domain formation via CTCF-mediated extrusion
        - Nov 13, 2015
    • You have access
      Accurate estimation of influenza epidemics using Google search data via ARGO
      Shihao Yang, Mauricio Santillana, and S. C. Kou
      PNAS November 24, 2015 112 (47) 14473-14478; first published November 9, 2015. https://doi.org/10.1073/pnas.1515373112
    • Open Access
      Choosing experiments to accelerate collective discovery
      Andrey Rzhetsky, Jacob G. Foster, Ian T. Foster, and James A. Evans
      PNAS November 24, 2015 112 (47) 14569-14574; first published November 9, 2015. https://doi.org/10.1073/pnas.1509757112
    • Open Access
      Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle
      Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, and Dietmar Plenz
      PNAS November 24, 2015 112 (47) 14694-14699; first published November 9, 2015. https://doi.org/10.1073/pnas.1513716112
  • Applied Physical Sciences

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      Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules
      Peter J. Chung, Myung Chul Choi, Herbert P. Miller, H. Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C. Feinstein, and Cyrus R. Safinya
      PNAS November 24, 2015 112 (47) E6416-E6425; first published November 5, 2015. https://doi.org/10.1073/pnas.1513172112
    • Open Access
      Mapping transient electric fields with picosecond electron bunches
      Long Chen, Runze Li, Jie Chen, Pengfei Zhu, Feng Liu, Jianming Cao, Zhengming Sheng, and Jie Zhang
      PNAS November 24, 2015 112 (47) 14479-14483; first published November 9, 2015. https://doi.org/10.1073/pnas.1518353112
    • You have access
      Self-assembly of smallest magnetic particles
      Sara Mehdizadeh Taheri, Maria Michaelis, Thomas Friedrich, Beate Förster, Markus Drechsler, Florian M. Römer, Peter Bösecke, Theyencheri Narayanan, Birgit Weber, Ingo Rehberg, Sabine Rosenfeldt, and Stephan Förster
      PNAS November 24, 2015 112 (47) 14484-14489; first published November 9, 2015. https://doi.org/10.1073/pnas.1511443112
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      Wetting and phase separation in soft adhesion
      Katharine E. Jensen, Raphael Sarfati, Robert W. Style, Rostislav Boltyanskiy, Aditi Chakrabarti, Manoj K. Chaudhury, and Eric R. Dufresne
      PNAS November 24, 2015 112 (47) 14490-14494; first published November 9, 2015. https://doi.org/10.1073/pnas.1514378112
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      Topological mechanics of gyroscopic metamaterials
      Lisa M. Nash, Dustin Kleckner, Alismari Read, Vincenzo Vitelli, Ari M. Turner, and William T. M. Irvine
      PNAS November 24, 2015 112 (47) 14495-14500; first published November 11, 2015. https://doi.org/10.1073/pnas.1507413112
    • Open Access
      Heterogeneous lamella structure unites ultrafine-grain strength with coarse-grain ductility
      Xiaolei Wu, Muxin Yang, Fuping Yuan, Guilin Wu, Yujie Wei, Xiaoxu Huang, and Yuntian Zhu
      PNAS November 24, 2015 112 (47) 14501-14505; first published November 9, 2015. https://doi.org/10.1073/pnas.1517193112
  • Chemistry

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      Electrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzyme
      Hope Adamson, Alexandr N. Simonov, Michelina Kierzek, Richard A. Rothery, Joel H. Weiner, Alan M. Bond, and Alison Parkin
      PNAS November 24, 2015 112 (47) 14506-14511; first published November 11, 2015. https://doi.org/10.1073/pnas.1516869112
  • Earth, Atmospheric, and Planetary Sciences

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      Shifts in coral reef biogeochemistry and resulting acidification linked to offshore productivity
      Kiley L. Yeakel, Andreas J. Andersson, Nicholas R. Bates, Timothy J. Noyes, Andrew Collins, and Rebecca Garley
      PNAS November 24, 2015 112 (47) 14512-14517; first published November 9, 2015. https://doi.org/10.1073/pnas.1507021112
    • Open Access
      Potentially biogenic carbon preserved in a 4.1 billion-year-old zircon
      • From the Cover
      Elizabeth A. Bell, Patrick Boehnke, T. Mark Harrison, and Wendy L. Mao
      PNAS November 24, 2015 112 (47) 14518-14521; first published October 19, 2015. https://doi.org/10.1073/pnas.1517557112

      See companion article:

      • Penciling in details of the Hadean
        - Nov 12, 2015
    • You have access
      Dynamic response of desert wetlands to abrupt climate change
      Kathleen B. Springer, Craig R. Manker, and Jeffrey S. Pigati
      PNAS November 24, 2015 112 (47) 14522-14526; first published November 9, 2015. https://doi.org/10.1073/pnas.1513352112
  • Engineering

    • Open Access
      Ultrasensitive gas detection of large-area boron-doped graphene
      Ruitao Lv, Gugang Chen, Qing Li, Amber McCreary, Andrés Botello-Méndez, S. V. Morozov, Liangbo Liang, Xavier Declerck, Nestor Perea-López, David A. Cullen, Simin Feng, Ana Laura Elías, Rodolfo Cruz-Silva, Kazunori Fujisawa, Morinobu Endo, Feiyu Kang, Jean-Christophe Charlier, Vincent Meunier, Minghu Pan, Avetik R. Harutyunyan, Konstantin S. Novoselov, and Mauricio Terrones
      PNAS November 24, 2015 112 (47) 14527-14532; first published November 2, 2015. https://doi.org/10.1073/pnas.1505993112
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      Ultraflexible, large-area, physiological temperature sensors for multipoint measurements
      Tomoyuki Yokota, Yusuke Inoue, Yuki Terakawa, Jonathan Reeder, Martin Kaltenbrunner, Taylor Ware, Kejia Yang, Kunihiko Mabuchi, Tomohiro Murakawa, Masaki Sekino, Walter Voit, Tsuyoshi Sekitani, and Takao Someya
      PNAS November 24, 2015 112 (47) 14533-14538; first published November 9, 2015. https://doi.org/10.1073/pnas.1515650112
    • You have access
      Optimal directional volatile transport in retronasal olfaction
      Rui Ni, Mark H. Michalski, Elliott Brown, Ngoc Doan, Joseph Zinter, Nicholas T. Ouellette, and Gordon M. Shepherd
      PNAS November 24, 2015 112 (47) 14700-14704; first published November 9, 2015. https://doi.org/10.1073/pnas.1511495112
  • Physics

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      Universal spectrum of normal modes in low-temperature glasses
      Silvio Franz, Giorgio Parisi, Pierfrancesco Urbani, and Francesco Zamponi
      PNAS November 24, 2015 112 (47) 14539-14544; first published November 11, 2015. https://doi.org/10.1073/pnas.1511134112
    • Open Access
      Deformation and failure of curved colloidal crystal shells
      Carlotta Negri, Alessandro L. Sellerio, Stefano Zapperi, and M. Carmen Miguel
      PNAS November 24, 2015 112 (47) 14545-14550; first published November 9, 2015. https://doi.org/10.1073/pnas.1518258112
    • You have access
      Filling constraints for spin-orbit coupled insulators in symmorphic and nonsymmorphic crystals
      Haruki Watanabe, Hoi Chun Po, Ashvin Vishwanath, and Michael Zaletel
      PNAS November 24, 2015 112 (47) 14551-14556; first published November 10, 2015. https://doi.org/10.1073/pnas.1514665112

Social Sciences

  • Economic Sciences

    • Open Access
      Retrading, production, and asset market performance
      Steven D. Gjerstad, David Porter, Vernon L. Smith, and Abel Winn
      PNAS November 24, 2015 112 (47) 14557-14562; first published November 9, 2015. https://doi.org/10.1073/pnas.1517038112
  • Psychological and Cognitive Sciences

    • Open Access
      Human emotions track changes in the acoustic environment
      Weiyi Ma and William Forde Thompson
      PNAS November 24, 2015 112 (47) 14563-14568; first published November 9, 2015. https://doi.org/10.1073/pnas.1515087112
  • Social Sciences

    • Open Access
      Choosing experiments to accelerate collective discovery
      Andrey Rzhetsky, Jacob G. Foster, Ian T. Foster, and James A. Evans
      PNAS November 24, 2015 112 (47) 14569-14574; first published November 9, 2015. https://doi.org/10.1073/pnas.1509757112

Biological Sciences

  • Applied Biological Sciences

    • Open Access
      Mapping landscape friction to locate isolated tsetse populations that are candidates for elimination
      Jérémy Bouyer, Ahmadou H. Dicko, Giuliano Cecchi, Sophie Ravel, Laure Guerrini, Philippe Solano, Marc J. B. Vreysen, Thierry De Meeûs, and Renaud Lancelot
      PNAS November 24, 2015 112 (47) 14575-14580; first published November 9, 2015. https://doi.org/10.1073/pnas.1516778112
  • Biochemistry

    • You have access
      Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck
      Sudeep Banjade, Qiong Wu, Anuradha Mittal, William B. Peeples, Rohit V. Pappu, and Michael K. Rosen
      PNAS November 24, 2015 112 (47) E6426-E6435; first published November 9, 2015. https://doi.org/10.1073/pnas.1508778112

      See companion article:

      • Allosteric activation of N-WASP by Nck
        - Nov 09, 2015
    • You have access
      Allosteric N-WASP activation by an inter-SH3 domain linker in Nck
      Julia Okrut, Sumit Prakash, Qiong Wu, Mark J. S. Kelly, and Jack Taunton
      PNAS November 24, 2015 112 (47) E6436-E6445; first published November 9, 2015. https://doi.org/10.1073/pnas.1510876112

      See companion article:

      • Conserved linker promotes phase separation of Nck
        - Nov 09, 2015
    • You have access
      Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection
      Hilda H. Au, Gabriel Cornilescu, Kathryn D. Mouzakis, Qian Ren, Jordan E. Burke, Seonghoon Lee, Samuel E. Butcher, and Eric Jan
      PNAS November 24, 2015 112 (47) E6446-E6455; first published November 9, 2015. https://doi.org/10.1073/pnas.1512088112
    • You have access
      Electrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzyme
      Hope Adamson, Alexandr N. Simonov, Michelina Kierzek, Richard A. Rothery, Joel H. Weiner, Alan M. Bond, and Alison Parkin
      PNAS November 24, 2015 112 (47) 14506-14511; first published November 11, 2015. https://doi.org/10.1073/pnas.1516869112
    • Open Access
      Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives
      Xin-min Li, Ke-wei Zheng, Jia-yu Zhang, Hong-he Liu, Yi-de He, Bi-feng Yuan, Yu-hua Hao, and Zheng Tan
      PNAS November 24, 2015 112 (47) 14581-14586; first published November 9, 2015. https://doi.org/10.1073/pnas.1516925112
    • You have access
      FOXO regulates RNA interference in Drosophila and protects from RNA virus infection
      Michael J. Spellberg and Michael T. Marr II
      PNAS November 24, 2015 112 (47) 14587-14592; first published November 9, 2015. https://doi.org/10.1073/pnas.1517124112
    • You have access
      Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V
      Darshan V. Trivedi, Joseph M. Muretta, Anja M. Swenson, Jonathon P. Davis, David D. Thomas, and Christopher M. Yengo
      PNAS November 24, 2015 112 (47) 14593-14598; first published November 9, 2015. https://doi.org/10.1073/pnas.1517566112
    • You have access
      Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
      Andrew R. Buller, Sabine Brinkmann-Chen, David K. Romney, Michael Herger, Javier Murciano-Calles, and Frances H. Arnold
      PNAS November 24, 2015 112 (47) 14599-14604; first published November 9, 2015. https://doi.org/10.1073/pnas.1516401112
  • Biophysics and Computational Biology

    • You have access
      Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules
      Peter J. Chung, Myung Chul Choi, Herbert P. Miller, H. Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C. Feinstein, and Cyrus R. Safinya
      PNAS November 24, 2015 112 (47) E6416-E6425; first published November 5, 2015. https://doi.org/10.1073/pnas.1513172112
    • Open Access
      Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
      Adrian L. Sanborn, Suhas S. P. Rao, Su-Chen Huang, Neva C. Durand, Miriam H. Huntley, Andrew I. Jewett, Ivan D. Bochkov, Dharmaraj Chinnappan, Ashok Cutkosky, Jian Li, Kristopher P. Geeting, Andreas Gnirke, Alexandre Melnikov, Doug McKenna, Elena K. Stamenova, Eric S. Lander, and Erez Lieberman Aiden
      PNAS November 24, 2015 112 (47) E6456-E6465; first published October 23, 2015. https://doi.org/10.1073/pnas.1518552112

      See companion article:

      • DNA domain formation via CTCF-mediated extrusion
        - Nov 13, 2015
    • You have access
      Designed protein reveals structural determinants of extreme kinetic stability
      Aron Broom, S. Martha Ma, Ke Xia, Hitesh Rafalia, Kyle Trainor, Wilfredo Colón, Shachi Gosavi, and Elizabeth M. Meiering
      PNAS November 24, 2015 112 (47) 14605-14610; first published November 9, 2015. https://doi.org/10.1073/pnas.1510748112
    • You have access
      Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy
      Si Yan, Changmiao Guo, Guangjin Hou, Huilan Zhang, Xingyu Lu, John Charles Williams, and Tatyana Polenova
      PNAS November 24, 2015 112 (47) 14611-14616; first published November 10, 2015. https://doi.org/10.1073/pnas.1509852112
    • You have access
      Dynamic allostery governs cyclophilin A–HIV capsid interplay
      Manman Lu, Guangjin Hou, Huilan Zhang, Christopher L. Suiter, Jinwoo Ahn, In-Ja L. Byeon, Juan R. Perilla, Christopher J. Langmead, Ivan Hung, Peter L. Gor'kov, Zhehong Gan, William Brey, Christopher Aiken, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, and Tatyana Polenova
      PNAS November 24, 2015 112 (47) 14617-14622; first published November 9, 2015. https://doi.org/10.1073/pnas.1516920112
  • Cell Biology

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      HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart
      Chi Keung Lam, Wen Zhao, Guan-Sheng Liu, Wen-Feng Cai, George Gardner, George Adly, and Evangelia G. Kranias
      PNAS November 24, 2015 112 (47) E6466-E6475; first published November 9, 2015. https://doi.org/10.1073/pnas.1508760112
    • You have access
      Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma
      Narayana Yeddula, Yifeng Xia, Eugene Ke, Joep Beumer, and Inder M. Verma
      PNAS November 24, 2015 112 (47) E6476-E6485; first published November 5, 2015. https://doi.org/10.1073/pnas.1520110112
    • Open Access
      TRPC6 channel translocation into phagosomal membrane augments phagosomal function
      Vladimir Riazanski, Aida G. Gabdoulkhakova, Lin S. Boynton, Raphael R. Eguchi, Ludmila V. Deriy, D. Kyle Hogarth, Nadège Loaëc, Nassima Oumata, Hervé Galons, Mary E. Brown, Pavel Shevchenko, Alexander J. Gallan, Sang Gune Yoo, Anjaparavanda P. Naren, Mitchel L. Villereal, Daniel W. Beacham, Vytautas P. Bindokas, Lutz Birnbaumer, Laurent Meijer, and Deborah J. Nelson
      PNAS November 24, 2015 112 (47) E6486-E6495; first published November 10, 2015. https://doi.org/10.1073/pnas.1518966112
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      A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation
      Christoffer K. Goth, Adnan Halim, Sumeet A. Khetarpal, Daniel J. Rader, Henrik Clausen, and Katrine T.-B. G. Schjoldager
      PNAS November 24, 2015 112 (47) 14623-14628; first published November 9, 2015. https://doi.org/10.1073/pnas.1511175112
  • Developmental Biology

    • Open Access
      Fourteen babies born after round spermatid injection into human oocytes
      Atsushi Tanaka, Motoi Nagayoshi, Youichi Takemoto, Izumi Tanaka, Hiroshi Kusunoki, Seiji Watanabe, Keiji Kuroda, Satoru Takeda, Masahiko Ito, and Ryuzo Yanagimachi
      PNAS November 24, 2015 112 (47) 14629-14634; first published November 2, 2015. https://doi.org/10.1073/pnas.1517466112
    • You have access
      Superresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes
      Kirti Prakash, David Fournier, Stefan Redl, Gerrit Best, Máté Borsos, Vijay K. Tiwari, Kikuë Tachibana-Konwalski, René F. Ketting, Sapun H. Parekh, Christoph Cremer, and Udo J. Birk
      PNAS November 24, 2015 112 (47) 14635-14640; first published November 11, 2015. https://doi.org/10.1073/pnas.1516928112
    • You have access
      Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons
      Yuki Hatanaka, Kimiko Inoue, Mami Oikawa, Satoshi Kamimura, Narumi Ogonuki, Eiichi N. Kodama, Yasuyuki Ohkawa, Yu-ichi Tsukada, and Atsuo Ogura
      PNAS November 24, 2015 112 (47) 14641-14646; first published November 6, 2015. https://doi.org/10.1073/pnas.1512775112
  • Environmental Sciences

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      Shifts in coral reef biogeochemistry and resulting acidification linked to offshore productivity
      Kiley L. Yeakel, Andreas J. Andersson, Nicholas R. Bates, Timothy J. Noyes, Andrew Collins, and Rebecca Garley
      PNAS November 24, 2015 112 (47) 14512-14517; first published November 9, 2015. https://doi.org/10.1073/pnas.1507021112
    • You have access
      Redistribution of soil water by a saprotrophic fungus enhances carbon mineralization
      Alexander Guhr, Werner Borken, Marie Spohn, and Egbert Matzner
      PNAS November 24, 2015 112 (47) 14647-14651; first published November 9, 2015. https://doi.org/10.1073/pnas.1514435112
    • You have access
      Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton
      Hugo Botebol, Emmanuel Lesuisse, Robert Šuták, Christophe Six, Jean-Claude Lozano, Philippe Schatt, Valérie Vergé, Amos Kirilovsky, Joe Morrissey, Thibaut Léger, Jean-Michel Camadro, Audrey Gueneugues, Chris Bowler, Stéphane Blain, and François-Yves Bouget
      PNAS November 24, 2015 112 (47) 14652-14657; first published November 9, 2015. https://doi.org/10.1073/pnas.1506074112
  • Evolution

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      Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
      Shaoping Ling, Zheng Hu, Zuyu Yang, Fang Yang, Yawei Li, Pei Lin, Ke Chen, Lili Dong, Lihua Cao, Yong Tao, Lingtong Hao, Qingjian Chen, Qiang Gong, Dafei Wu, Wenjie Li, Wenming Zhao, Xiuyun Tian, Chunyi Hao, Eric A. Hungate, Daniel V. T. Catenacci, Richard R. Hudson, Wen-Hsiung Li, Xuemei Lu, and Chung-I Wu
      PNAS November 24, 2015 112 (47) E6496-E6505; first published November 11, 2015. https://doi.org/10.1073/pnas.1519556112
  • Genetics

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      Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line
      • From the Cover
      • Inaugural Article
      Sha Sun, Bernhard Payer, Satoshi Namekawa, Jee Young An, William Press, Jovani Catalan-Dibene, Hongjae Sunwoo, and Jeannie T. Lee
      PNAS November 24, 2015 112 (47) 14415-14422; first published October 21, 2015. https://doi.org/10.1073/pnas.1519528112

      See companion article:

      • QnAs with Jeannie T. Lee
        - Nov 18, 2015

      See companion article:

      • Imprinted X inactivation and hemizygosity converge
        - Nov 17, 2015
    • Open Access
      Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
      Paul J. McLaren, Cedric Coulonges, István Bartha, Tobias L. Lenz, Aaron J. Deutsch, Arman Bashirova, Susan Buchbinder, Mary N. Carrington, Andrea Cossarizza, Judith Dalmau, Andrea De Luca, James J. Goedert, Deepti Gurdasani, David W. Haas, Joshua T. Herbeck, Eric O. Johnson, Gregory D. Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M. Miro, James I. Mullins, Niels Obel, Guido Poli, Manjinder S. Sandhu, Hanneke Schuitemaker, Patrick R. Shea, Ioannis Theodorou, Bruce D. Walker, Amy C. Weintrob, Cheryl A. Winkler, Steven M. Wolinsky, Soumya Raychaudhuri, David B. Goldstein, Amalio Telenti, Paul I. W. de Bakker, Jean-François Zagury, and Jacques Fellay
      PNAS November 24, 2015 112 (47) 14658-14663; first published November 9, 2015. https://doi.org/10.1073/pnas.1514867112
  • Immunology and Inflammation

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      Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging
      Roy L. Maute, Sydney R. Gordon, Aaron T. Mayer, Melissa N. McCracken, Arutselvan Natarajan, Nan Guo Ring, Richard Kimura, Jonathan M. Tsai, Aashish Manglik, Andrew C. Kruse, Sanjiv S. Gambhir, Irving L. Weissman, and Aaron M. Ring
      PNAS November 24, 2015 112 (47) E6506-E6514; first published November 10, 2015. https://doi.org/10.1073/pnas.1519623112
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      An extracatalytic function of CD45 in B cells is mediated by CD22
      Sarah Coughlin, Mark Noviski, James L. Mueller, Ammarina Chuwonpad, William C. Raschke, Arthur Weiss, and Julie Zikherman
      PNAS November 24, 2015 112 (47) E6515-E6524; first published November 11, 2015. https://doi.org/10.1073/pnas.1519925112
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      Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells
      Anand K. Katakam, Hans Brightbill, Christian Franci, Chung Kung, Victor Nunez, Charles Jones III, Ivan Peng, Surinder Jeet, Lawren C. Wu, Ira Mellman, Lélia Delamarre, and Cary D. Austin
      PNAS November 24, 2015 112 (47) 14664-14669; first published November 11, 2015. https://doi.org/10.1073/pnas.1520627112
  • Medical Sciences

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      Targeting CD146 with a 64Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas
      Yunan Yang, Reinier Hernandez, Jun Rao, Li Yin, Yazhuo Qu, Jinrong Wu, Christopher G. England, Stephen A. Graves, Christina M. Lewis, Pu Wang, Mary E. Meyerand, Robert J. Nickles, Xiu-wu Bian, and Weibo Cai
      PNAS November 24, 2015 112 (47) E6525-E6534; first published November 9, 2015. https://doi.org/10.1073/pnas.1502648112
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      Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis
      Seong-Hye Hwang, Seung-Hyun Jung, Saseong Lee, Susanna Choi, Seung-Ah Yoo, Ji-Hwan Park, Daehee Hwang, Seung Cheol Shim, Laurent Sabbagh, Ki-Jo Kim, Sung Hwan Park, Chul-Soo Cho, Bong-Sung Kim, Lin Leng, Ruth R. Montgomery, Richard Bucala, Yeun-Jun Chung, and Wan-Uk Kim
      PNAS November 24, 2015 112 (47) E6535-E6543; first published November 9, 2015. https://doi.org/10.1073/pnas.1514152112
    • Open Access
      A basal stem cell signature identifies aggressive prostate cancer phenotypes
      Bryan A. Smith, Artem Sokolov, Vladislav Uzunangelov, Robert Baertsch, Yulia Newton, Kiley Graim, Colleen Mathis, Donghui Cheng, Joshua M. Stuart, and Owen N. Witte
      PNAS November 24, 2015 112 (47) E6544-E6552; first published October 12, 2015. https://doi.org/10.1073/pnas.1518007112

      See companion article:

      • Neuroendocrine stem-like prostate tumors
        - Nov 17, 2015
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      Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA
      Ai-hua Yin, Chun-fang Peng, Xin Zhao, Bennett A. Caughey, Jie-xia Yang, Jian Liu, Wei-wei Huang, Chang Liu, Dong-hong Luo, Hai-liang Liu, Yang-yi Chen, Jing Wu, Rui Hou, Mindy Zhang, Michael Ai, Lianghong Zheng, Rachel Q. Xue, Ming-qin Mai, Fang-fang Guo, Yi-ming Qi, Dong-mei Wang, Michal Krawczyk, Daniel Zhang, Yu-nan Wang, Quan-fei Huang, Michael Karin, and Kang Zhang
      PNAS November 24, 2015 112 (47) 14670-14675; first published November 9, 2015. https://doi.org/10.1073/pnas.1518151112
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      Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model
      Xing Gao, Yingchao Zhao, Anat O. Stemmer-Rachamimov, Hao Liu, Peigen Huang, ShanMin Chin, Martin K. Selig, Scott R. Plotkin, Rakesh K. Jain, and Lei Xu
      PNAS November 24, 2015 112 (47) 14676-14681; first published November 9, 2015. https://doi.org/10.1073/pnas.1512570112
  • Microbiology

    • Open Access
      Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses
      Audrey Stéphanie Richard, Adam Zhang, Sun-Jin Park, Michael Farzan, Min Zong, and Hyeryun Choe
      PNAS November 24, 2015 112 (47) 14682-14687; first published November 2, 2015. https://doi.org/10.1073/pnas.1508095112
    • Open Access
      Asymptomatic humans transmit dengue virus to mosquitoes
      Veasna Duong, Louis Lambrechts, Richard E. Paul, Sowath Ly, Rath Srey Lay, Kanya C. Long, Rekol Huy, Arnaud Tarantola, Thomas W. Scott, Anavaj Sakuntabhai, and Philippe Buchy
      PNAS November 24, 2015 112 (47) 14688-14693; first published November 9, 2015. https://doi.org/10.1073/pnas.1508114112
  • Neuroscience

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      A 3′ untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR
      Joshua A. Suhl, Ravi S. Muddashetty, Bart R. Anderson, Marius F. Ifrim, Jeannie Visootsak, Gary J. Bassell, and Stephen T. Warren
      PNAS November 24, 2015 112 (47) E6553-E6561; first published November 9, 2015. https://doi.org/10.1073/pnas.1514260112
    • Open Access
      Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle
      Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, and Dietmar Plenz
      PNAS November 24, 2015 112 (47) 14694-14699; first published November 9, 2015. https://doi.org/10.1073/pnas.1513716112
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      Optimal directional volatile transport in retronasal olfaction
      Rui Ni, Mark H. Michalski, Elliott Brown, Ngoc Doan, Joseph Zinter, Nicholas T. Ouellette, and Gordon M. Shepherd
      PNAS November 24, 2015 112 (47) 14700-14704; first published November 9, 2015. https://doi.org/10.1073/pnas.1511495112
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      Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow
      Kim Dore, Jonathan Aow, and Roberto Malinow
      PNAS November 24, 2015 112 (47) 14705-14710; first published November 9, 2015. https://doi.org/10.1073/pnas.1520023112

      See companion article:

      • Conformational signaling by the NMDAR complex
        - Nov 09, 2015
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      Conformational signaling required for synaptic plasticity by the NMDA receptor complex
      Jonathan Aow, Kim Dore, and Roberto Malinow
      PNAS November 24, 2015 112 (47) 14711-14716; first published November 9, 2015. https://doi.org/10.1073/pnas.1520029112

      See companion article:

      • Measurement of NMDA receptor metabotropic function
        - Nov 09, 2015
    • You have access
      Whole-agent selectivity within the macaque face-processing system
      • From the Cover
      Clark Fisher and Winrich A. Freiwald
      PNAS November 24, 2015 112 (47) 14717-14722; first published October 13, 2015. https://doi.org/10.1073/pnas.1512378112

      See companion article:

      • Head to toe, in the head
        - Nov 23, 2015
    • You have access
      Unmyelinated type II afferent neurons report cochlear damage
      Chang Liu, Elisabeth Glowatzki, and Paul Albert Fuchs
      PNAS November 24, 2015 112 (47) 14723-14727; first published November 9, 2015. https://doi.org/10.1073/pnas.1515228112
  • Pharmacology

    • Open Access
      Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope
      Shang-Yi A. Tsai, Jian-Ying Chuang, Meng-Shan Tsai, Xiao-fei Wang, Zheng-Xiong Xi, Jan-Jong Hung, Wen-Chang Chang, Antonello Bonci, and Tsung-Ping Su
      PNAS November 24, 2015 112 (47) E6562-E6570; first published November 9, 2015. https://doi.org/10.1073/pnas.1518894112
  • Plant Biology

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      A vacuolar phosphate transporter essential for phosphate homeostasis in Arabidopsis
      Jinlong Liu, Lei Yang, Mingda Luan, Yuan Wang, Chi Zhang, Bin Zhang, Jisen Shi, Fu-Geng Zhao, Wenzhi Lan, and Sheng Luan
      PNAS November 24, 2015 112 (47) E6571-E6578; first published November 9, 2015. https://doi.org/10.1073/pnas.1514598112
    • You have access
      RNA-directed DNA methylation enforces boundaries between heterochromatin and euchromatin in the maize genome
      Qing Li, Jonathan I. Gent, Greg Zynda, Jawon Song, Irina Makarevitch, Cory D. Hirsch, Candice N. Hirsch, R. Kelly Dawe, Thelma F. Madzima, Karen M. McGinnis, Damon Lisch, Robert J. Schmitz, Matthew W. Vaughn, and Nathan M. Springer
      PNAS November 24, 2015 112 (47) 14728-14733; first published November 9, 2015. https://doi.org/10.1073/pnas.1514680112
    • You have access
      QQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactions
      Ling Li, Wenguang Zheng, Yanbing Zhu, Huaxun Ye, Buyun Tang, Zebulun W. Arendsee, Dallas Jones, Ruoran Li, Diego Ortiz, Xuefeng Zhao, Chuanlong Du, Dan Nettleton, M. Paul Scott, Maria G. Salas-Fernandez, Yanhai Yin, and Eve Syrkin Wurtele
      PNAS November 24, 2015 112 (47) 14734-14739; first published November 9, 2015. https://doi.org/10.1073/pnas.1514670112
  • Psychological and Cognitive Sciences

    • Open Access
      Human emotions track changes in the acoustic environment
      Weiyi Ma and William Forde Thompson
      PNAS November 24, 2015 112 (47) 14563-14568; first published November 9, 2015. https://doi.org/10.1073/pnas.1515087112
  • Systems Biology

    • Open Access
      Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
      Florian Atger, Cédric Gobet, Julien Marquis, Eva Martin, Jingkui Wang, Benjamin Weger, Grégory Lefebvre, Patrick Descombes, Felix Naef, and Frédéric Gachon
      PNAS November 24, 2015 112 (47) E6579-E6588; first published November 9, 2015. https://doi.org/10.1073/pnas.1515308112

Corrections (Online Only)

  • You have access
    Correction for O’Dwyer et al., Backbones of evolutionary history test biodiversity theory for microbes
    PNAS November 24, 2015 112 (47) E6589; first published November 9, 2015. https://doi.org/10.1073/pnas.1520755112
  • You have access
    Correction for Rasmussen et al., Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla–Wagner model
    PNAS November 24, 2015 112 (47) E6590; first published November 16, 2015. https://doi.org/10.1073/pnas.1521346112
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Proceedings of the National Academy of Sciences: 112 (47)
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