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Table of Contents
November 24, 2015; vol. 112 no. 47
This Week in PNAS
Letters (Online Only)
- You have accessGenetics of alcohol use disorders: Actin gets into the actGolo Kronenberg, Matthias Endres, and Karen GertzPNAS November 24, 2015 112 (47) E6411; first published October 29, 2015. https://doi.org/10.1073/pnas.1514716112
- You have accessDistinguishing phases of biomedical research is critical to improving health outcomesKevin FiscellaPNAS November 24, 2015 112 (47) E6412; first published November 10, 2015. https://doi.org/10.1073/pnas.1518862112
- You have accessReply to Fiscella: The phases of biomedical research should be studied to optimize health outcomesAnthony Bowen and Arturo CasadevallPNAS November 24, 2015 112 (47) E6413; first published November 10, 2015. https://doi.org/10.1073/pnas.1519759112
See companion article:
- Input-outcome disparities in biomedical research- Aug 17, 2015
- You have accessVaginal microbiota during pregnancy: Pathways of risk of preterm delivery in the absence of intrauterine infection?Jeffrey A. Keelan and Matthew S. PaynePNAS November 24, 2015 112 (47) E6414; first published October 29, 2015. https://doi.org/10.1073/pnas.1517346112
- You have accessReply to Keelan and Payne: Microbiota-related pathways for preterm birthDaniel B. DiGiulio, David K. Stevenson, Gary Shaw, Deirdre J. Lyell, and David A. RelmanPNAS November 24, 2015 112 (47) E6415; first published October 29, 2015. https://doi.org/10.1073/pnas.1517939112
See companion article:
- Microbiota during pregnancy- Aug 17, 2015
News Feature
An in-depth look at trending science issues.
- You have accessNews Feature: How online studies are transforming psychology research
- Front Matter
Amber Dance
PNAS Plus Significance Statements
Brief statements written by the authors about the significance of their papers.
The Engineering of Biology and Medicine PNAS 100th Anniversary Special Feature (Free Online)
Introduction
- You have accessThe Engineering of Biology and Medicine
- From the Cover
Mark E. Davis and Robert LangerPNAS November 24, 2015 112 (47) 14423; first published November 23, 2015. https://doi.org/10.1073/pnas.1517450112
Perspectives
- You have accessAdvancing biomedical imagingRalph Weissleder and Matthias NahrendorfPNAS November 24, 2015 112 (47) 14424-14428; first published November 23, 2015. https://doi.org/10.1073/pnas.1508524112
- You have accessSynthetic biology devices for in vitro and in vivo diagnosticsShimyn Slomovic, Keith Pardee, and James J. CollinsPNAS November 24, 2015 112 (47) 14429-14435; first published November 23, 2015. https://doi.org/10.1073/pnas.1508521112
- You have accessNanotechnologies for biomedical science and translational medicineJames R. HeathPNAS November 24, 2015 112 (47) 14436-14443; first published November 23, 2015. https://doi.org/10.1073/pnas.1515202112
- You have accessProgress in material design for biomedical applicationsMark W. Tibbitt, Christopher B. Rodell, Jason A. Burdick, and Kristi S. AnsethPNAS November 24, 2015 112 (47) 14444-14451; first published November 23, 2015. https://doi.org/10.1073/pnas.1516247112
- You have accessRegenerative medicine: Current therapies and future directionsAngelo S. Mao and David J. MooneyPNAS November 24, 2015 112 (47) 14452-14459; first published November 23, 2015. https://doi.org/10.1073/pnas.1508520112
- You have accessSmart nanosystems: Bio-inspired technologies that interact with the host environmentEster J. Kwon, Justin H. Lo, and Sangeeta N. BhatiaPNAS November 24, 2015 112 (47) 14460-14466; first published November 23, 2015. https://doi.org/10.1073/pnas.1508522112
- You have accessEngineering opportunities in cancer immunotherapyLaura Jeanbart and Melody A. SwartzPNAS November 24, 2015 112 (47) 14467-14472; first published November 23, 2015. https://doi.org/10.1073/pnas.1508516112
Physical Sciences
Applied Mathematics
- Open AccessChromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomesAdrian L. Sanborn, Suhas S. P. Rao, Su-Chen Huang, Neva C. Durand, Miriam H. Huntley, Andrew I. Jewett, Ivan D. Bochkov, Dharmaraj Chinnappan, Ashok Cutkosky, Jian Li, Kristopher P. Geeting, Andreas Gnirke, Alexandre Melnikov, Doug McKenna, Elena K. Stamenova, Eric S. Lander, and Erez Lieberman AidenPNAS November 24, 2015 112 (47) E6456-E6465; first published October 23, 2015. https://doi.org/10.1073/pnas.1518552112
See companion article:
- DNA domain formation via CTCF-mediated extrusion- Nov 13, 2015
- You have accessAccurate estimation of influenza epidemics using Google search data via ARGOShihao Yang, Mauricio Santillana, and S. C. KouPNAS November 24, 2015 112 (47) 14473-14478; first published November 9, 2015. https://doi.org/10.1073/pnas.1515373112
- Open AccessChoosing experiments to accelerate collective discoveryAndrey Rzhetsky, Jacob G. Foster, Ian T. Foster, and James A. EvansPNAS November 24, 2015 112 (47) 14569-14574; first published November 9, 2015. https://doi.org/10.1073/pnas.1509757112
- Open AccessIntrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycleChristian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, and Dietmar PlenzPNAS November 24, 2015 112 (47) 14694-14699; first published November 9, 2015. https://doi.org/10.1073/pnas.1513716112
Applied Physical Sciences
- You have accessDirect force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubulesPeter J. Chung, Myung Chul Choi, Herbert P. Miller, H. Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C. Feinstein, and Cyrus R. SafinyaPNAS November 24, 2015 112 (47) E6416-E6425; first published November 5, 2015. https://doi.org/10.1073/pnas.1513172112
- Open AccessMapping transient electric fields with picosecond electron bunchesLong Chen, Runze Li, Jie Chen, Pengfei Zhu, Feng Liu, Jianming Cao, Zhengming Sheng, and Jie ZhangPNAS November 24, 2015 112 (47) 14479-14483; first published November 9, 2015. https://doi.org/10.1073/pnas.1518353112
- You have accessSelf-assembly of smallest magnetic particlesSara Mehdizadeh Taheri, Maria Michaelis, Thomas Friedrich, Beate Förster, Markus Drechsler, Florian M. Römer, Peter Bösecke, Theyencheri Narayanan, Birgit Weber, Ingo Rehberg, Sabine Rosenfeldt, and Stephan FörsterPNAS November 24, 2015 112 (47) 14484-14489; first published November 9, 2015. https://doi.org/10.1073/pnas.1511443112
- You have accessWetting and phase separation in soft adhesionKatharine E. Jensen, Raphael Sarfati, Robert W. Style, Rostislav Boltyanskiy, Aditi Chakrabarti, Manoj K. Chaudhury, and Eric R. DufresnePNAS November 24, 2015 112 (47) 14490-14494; first published November 9, 2015. https://doi.org/10.1073/pnas.1514378112
- You have accessTopological mechanics of gyroscopic metamaterialsLisa M. Nash, Dustin Kleckner, Alismari Read, Vincenzo Vitelli, Ari M. Turner, and William T. M. IrvinePNAS November 24, 2015 112 (47) 14495-14500; first published November 11, 2015. https://doi.org/10.1073/pnas.1507413112
- Open AccessHeterogeneous lamella structure unites ultrafine-grain strength with coarse-grain ductilityXiaolei Wu, Muxin Yang, Fuping Yuan, Guilin Wu, Yujie Wei, Xiaoxu Huang, and Yuntian ZhuPNAS November 24, 2015 112 (47) 14501-14505; first published November 9, 2015. https://doi.org/10.1073/pnas.1517193112
Chemistry
- You have accessElectrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzymeHope Adamson, Alexandr N. Simonov, Michelina Kierzek, Richard A. Rothery, Joel H. Weiner, Alan M. Bond, and Alison ParkinPNAS November 24, 2015 112 (47) 14506-14511; first published November 11, 2015. https://doi.org/10.1073/pnas.1516869112
Earth, Atmospheric, and Planetary Sciences
- You have accessShifts in coral reef biogeochemistry and resulting acidification linked to offshore productivityKiley L. Yeakel, Andreas J. Andersson, Nicholas R. Bates, Timothy J. Noyes, Andrew Collins, and Rebecca GarleyPNAS November 24, 2015 112 (47) 14512-14517; first published November 9, 2015. https://doi.org/10.1073/pnas.1507021112
- Open AccessPotentially biogenic carbon preserved in a 4.1 billion-year-old zircon
- From the Cover
Elizabeth A. Bell, Patrick Boehnke, T. Mark Harrison, and Wendy L. MaoPNAS November 24, 2015 112 (47) 14518-14521; first published October 19, 2015. https://doi.org/10.1073/pnas.1517557112See companion article:
- Penciling in details of the Hadean- Nov 12, 2015
- You have accessDynamic response of desert wetlands to abrupt climate changeKathleen B. Springer, Craig R. Manker, and Jeffrey S. PigatiPNAS November 24, 2015 112 (47) 14522-14526; first published November 9, 2015. https://doi.org/10.1073/pnas.1513352112
Engineering
- Open AccessUltrasensitive gas detection of large-area boron-doped grapheneRuitao Lv, Gugang Chen, Qing Li, Amber McCreary, Andrés Botello-Méndez, S. V. Morozov, Liangbo Liang, Xavier Declerck, Nestor Perea-López, David A. Cullen, Simin Feng, Ana Laura Elías, Rodolfo Cruz-Silva, Kazunori Fujisawa, Morinobu Endo, Feiyu Kang, Jean-Christophe Charlier, Vincent Meunier, Minghu Pan, Avetik R. Harutyunyan, Konstantin S. Novoselov, and Mauricio TerronesPNAS November 24, 2015 112 (47) 14527-14532; first published November 2, 2015. https://doi.org/10.1073/pnas.1505993112
- You have accessUltraflexible, large-area, physiological temperature sensors for multipoint measurementsTomoyuki Yokota, Yusuke Inoue, Yuki Terakawa, Jonathan Reeder, Martin Kaltenbrunner, Taylor Ware, Kejia Yang, Kunihiko Mabuchi, Tomohiro Murakawa, Masaki Sekino, Walter Voit, Tsuyoshi Sekitani, and Takao SomeyaPNAS November 24, 2015 112 (47) 14533-14538; first published November 9, 2015. https://doi.org/10.1073/pnas.1515650112
- You have accessOptimal directional volatile transport in retronasal olfactionRui Ni, Mark H. Michalski, Elliott Brown, Ngoc Doan, Joseph Zinter, Nicholas T. Ouellette, and Gordon M. ShepherdPNAS November 24, 2015 112 (47) 14700-14704; first published November 9, 2015. https://doi.org/10.1073/pnas.1511495112
Physics
- You have accessUniversal spectrum of normal modes in low-temperature glassesSilvio Franz, Giorgio Parisi, Pierfrancesco Urbani, and Francesco ZamponiPNAS November 24, 2015 112 (47) 14539-14544; first published November 11, 2015. https://doi.org/10.1073/pnas.1511134112
- Open AccessDeformation and failure of curved colloidal crystal shellsCarlotta Negri, Alessandro L. Sellerio, Stefano Zapperi, and M. Carmen MiguelPNAS November 24, 2015 112 (47) 14545-14550; first published November 9, 2015. https://doi.org/10.1073/pnas.1518258112
- You have accessFilling constraints for spin-orbit coupled insulators in symmorphic and nonsymmorphic crystalsHaruki Watanabe, Hoi Chun Po, Ashvin Vishwanath, and Michael ZaletelPNAS November 24, 2015 112 (47) 14551-14556; first published November 10, 2015. https://doi.org/10.1073/pnas.1514665112
Social Sciences
Economic Sciences
- Open AccessRetrading, production, and asset market performanceSteven D. Gjerstad, David Porter, Vernon L. Smith, and Abel WinnPNAS November 24, 2015 112 (47) 14557-14562; first published November 9, 2015. https://doi.org/10.1073/pnas.1517038112
Psychological and Cognitive Sciences
- Open AccessHuman emotions track changes in the acoustic environmentWeiyi Ma and William Forde ThompsonPNAS November 24, 2015 112 (47) 14563-14568; first published November 9, 2015. https://doi.org/10.1073/pnas.1515087112
Social Sciences
- Open AccessChoosing experiments to accelerate collective discoveryAndrey Rzhetsky, Jacob G. Foster, Ian T. Foster, and James A. EvansPNAS November 24, 2015 112 (47) 14569-14574; first published November 9, 2015. https://doi.org/10.1073/pnas.1509757112
Biological Sciences
Applied Biological Sciences
- Open AccessMapping landscape friction to locate isolated tsetse populations that are candidates for eliminationJérémy Bouyer, Ahmadou H. Dicko, Giuliano Cecchi, Sophie Ravel, Laure Guerrini, Philippe Solano, Marc J. B. Vreysen, Thierry De Meeûs, and Renaud LancelotPNAS November 24, 2015 112 (47) 14575-14580; first published November 9, 2015. https://doi.org/10.1073/pnas.1516778112
Biochemistry
- You have accessConserved interdomain linker promotes phase separation of the multivalent adaptor protein NckSudeep Banjade, Qiong Wu, Anuradha Mittal, William B. Peeples, Rohit V. Pappu, and Michael K. RosenPNAS November 24, 2015 112 (47) E6426-E6435; first published November 9, 2015. https://doi.org/10.1073/pnas.1508778112
See companion article:
- Allosteric activation of N-WASP by Nck- Nov 09, 2015
- You have accessAllosteric N-WASP activation by an inter-SH3 domain linker in NckJulia Okrut, Sumit Prakash, Qiong Wu, Mark J. S. Kelly, and Jack TauntonPNAS November 24, 2015 112 (47) E6436-E6445; first published November 9, 2015. https://doi.org/10.1073/pnas.1510876112
See companion article:
- Conserved linker promotes phase separation of Nck- Nov 09, 2015
- You have accessGlobal shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selectionHilda H. Au, Gabriel Cornilescu, Kathryn D. Mouzakis, Qian Ren, Jordan E. Burke, Seonghoon Lee, Samuel E. Butcher, and Eric JanPNAS November 24, 2015 112 (47) E6446-E6455; first published November 9, 2015. https://doi.org/10.1073/pnas.1512088112
- You have accessElectrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzymeHope Adamson, Alexandr N. Simonov, Michelina Kierzek, Richard A. Rothery, Joel H. Weiner, Alan M. Bond, and Alison ParkinPNAS November 24, 2015 112 (47) 14506-14511; first published November 11, 2015. https://doi.org/10.1073/pnas.1516869112
- Open AccessGuanine-vacancy–bearing G-quadruplexes responsive to guanine derivativesXin-min Li, Ke-wei Zheng, Jia-yu Zhang, Hong-he Liu, Yi-de He, Bi-feng Yuan, Yu-hua Hao, and Zheng TanPNAS November 24, 2015 112 (47) 14581-14586; first published November 9, 2015. https://doi.org/10.1073/pnas.1516925112
- You have accessFOXO regulates RNA interference in Drosophila and protects from RNA virus infectionMichael J. Spellberg and Michael T. Marr IIPNAS November 24, 2015 112 (47) 14587-14592; first published November 9, 2015. https://doi.org/10.1073/pnas.1517124112
- You have accessDirect measurements of the coordination of lever arm swing and the catalytic cycle in myosin VDarshan V. Trivedi, Joseph M. Muretta, Anja M. Swenson, Jonathon P. Davis, David D. Thomas, and Christopher M. YengoPNAS November 24, 2015 112 (47) 14593-14598; first published November 9, 2015. https://doi.org/10.1073/pnas.1517566112
- You have accessDirected evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activationAndrew R. Buller, Sabine Brinkmann-Chen, David K. Romney, Michael Herger, Javier Murciano-Calles, and Frances H. ArnoldPNAS November 24, 2015 112 (47) 14599-14604; first published November 9, 2015. https://doi.org/10.1073/pnas.1516401112
Biophysics and Computational Biology
- You have accessDirect force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubulesPeter J. Chung, Myung Chul Choi, Herbert P. Miller, H. Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C. Feinstein, and Cyrus R. SafinyaPNAS November 24, 2015 112 (47) E6416-E6425; first published November 5, 2015. https://doi.org/10.1073/pnas.1513172112
- Open AccessChromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomesAdrian L. Sanborn, Suhas S. P. Rao, Su-Chen Huang, Neva C. Durand, Miriam H. Huntley, Andrew I. Jewett, Ivan D. Bochkov, Dharmaraj Chinnappan, Ashok Cutkosky, Jian Li, Kristopher P. Geeting, Andreas Gnirke, Alexandre Melnikov, Doug McKenna, Elena K. Stamenova, Eric S. Lander, and Erez Lieberman AidenPNAS November 24, 2015 112 (47) E6456-E6465; first published October 23, 2015. https://doi.org/10.1073/pnas.1518552112
See companion article:
- DNA domain formation via CTCF-mediated extrusion- Nov 13, 2015
- You have accessDesigned protein reveals structural determinants of extreme kinetic stabilityAron Broom, S. Martha Ma, Ke Xia, Hitesh Rafalia, Kyle Trainor, Wilfredo Colón, Shachi Gosavi, and Elizabeth M. MeieringPNAS November 24, 2015 112 (47) 14605-14610; first published November 9, 2015. https://doi.org/10.1073/pnas.1510748112
- You have accessAtomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopySi Yan, Changmiao Guo, Guangjin Hou, Huilan Zhang, Xingyu Lu, John Charles Williams, and Tatyana PolenovaPNAS November 24, 2015 112 (47) 14611-14616; first published November 10, 2015. https://doi.org/10.1073/pnas.1509852112
- You have accessDynamic allostery governs cyclophilin A–HIV capsid interplayManman Lu, Guangjin Hou, Huilan Zhang, Christopher L. Suiter, Jinwoo Ahn, In-Ja L. Byeon, Juan R. Perilla, Christopher J. Langmead, Ivan Hung, Peter L. Gor'kov, Zhehong Gan, William Brey, Christopher Aiken, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, and Tatyana PolenovaPNAS November 24, 2015 112 (47) 14617-14622; first published November 9, 2015. https://doi.org/10.1073/pnas.1516920112
Cell Biology
- You have accessHAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heartChi Keung Lam, Wen Zhao, Guan-Sheng Liu, Wen-Feng Cai, George Gardner, George Adly, and Evangelia G. KraniasPNAS November 24, 2015 112 (47) E6466-E6475; first published November 9, 2015. https://doi.org/10.1073/pnas.1508760112
- You have accessScreening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinomaNarayana Yeddula, Yifeng Xia, Eugene Ke, Joep Beumer, and Inder M. VermaPNAS November 24, 2015 112 (47) E6476-E6485; first published November 5, 2015. https://doi.org/10.1073/pnas.1520110112
- Open AccessTRPC6 channel translocation into phagosomal membrane augments phagosomal functionVladimir Riazanski, Aida G. Gabdoulkhakova, Lin S. Boynton, Raphael R. Eguchi, Ludmila V. Deriy, D. Kyle Hogarth, Nadège Loaëc, Nassima Oumata, Hervé Galons, Mary E. Brown, Pavel Shevchenko, Alexander J. Gallan, Sang Gune Yoo, Anjaparavanda P. Naren, Mitchel L. Villereal, Daniel W. Beacham, Vytautas P. Bindokas, Lutz Birnbaumer, Laurent Meijer, and Deborah J. NelsonPNAS November 24, 2015 112 (47) E6486-E6495; first published November 10, 2015. https://doi.org/10.1073/pnas.1518966112
- You have accessA systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylationChristoffer K. Goth, Adnan Halim, Sumeet A. Khetarpal, Daniel J. Rader, Henrik Clausen, and Katrine T.-B. G. SchjoldagerPNAS November 24, 2015 112 (47) 14623-14628; first published November 9, 2015. https://doi.org/10.1073/pnas.1511175112
Developmental Biology
- Open AccessFourteen babies born after round spermatid injection into human oocytesAtsushi Tanaka, Motoi Nagayoshi, Youichi Takemoto, Izumi Tanaka, Hiroshi Kusunoki, Seiji Watanabe, Keiji Kuroda, Satoru Takeda, Masahiko Ito, and Ryuzo YanagimachiPNAS November 24, 2015 112 (47) 14629-14634; first published November 2, 2015. https://doi.org/10.1073/pnas.1517466112
- You have accessSuperresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomesKirti Prakash, David Fournier, Stefan Redl, Gerrit Best, Máté Borsos, Vijay K. Tiwari, Kikuë Tachibana-Konwalski, René F. Ketting, Sapun H. Parekh, Christoph Cremer, and Udo J. BirkPNAS November 24, 2015 112 (47) 14635-14640; first published November 11, 2015. https://doi.org/10.1073/pnas.1516928112
- You have accessHistone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposonsYuki Hatanaka, Kimiko Inoue, Mami Oikawa, Satoshi Kamimura, Narumi Ogonuki, Eiichi N. Kodama, Yasuyuki Ohkawa, Yu-ichi Tsukada, and Atsuo OguraPNAS November 24, 2015 112 (47) 14641-14646; first published November 6, 2015. https://doi.org/10.1073/pnas.1512775112
Environmental Sciences
- You have accessShifts in coral reef biogeochemistry and resulting acidification linked to offshore productivityKiley L. Yeakel, Andreas J. Andersson, Nicholas R. Bates, Timothy J. Noyes, Andrew Collins, and Rebecca GarleyPNAS November 24, 2015 112 (47) 14512-14517; first published November 9, 2015. https://doi.org/10.1073/pnas.1507021112
- You have accessRedistribution of soil water by a saprotrophic fungus enhances carbon mineralizationAlexander Guhr, Werner Borken, Marie Spohn, and Egbert MatznerPNAS November 24, 2015 112 (47) 14647-14651; first published November 9, 2015. https://doi.org/10.1073/pnas.1514435112
- You have accessCentral role for ferritin in the day/night regulation of iron homeostasis in marine phytoplanktonHugo Botebol, Emmanuel Lesuisse, Robert Šuták, Christophe Six, Jean-Claude Lozano, Philippe Schatt, Valérie Vergé, Amos Kirilovsky, Joe Morrissey, Thibaut Léger, Jean-Michel Camadro, Audrey Gueneugues, Chris Bowler, Stéphane Blain, and François-Yves BougetPNAS November 24, 2015 112 (47) 14652-14657; first published November 9, 2015. https://doi.org/10.1073/pnas.1506074112
Evolution
- You have accessExtremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolutionShaoping Ling, Zheng Hu, Zuyu Yang, Fang Yang, Yawei Li, Pei Lin, Ke Chen, Lili Dong, Lihua Cao, Yong Tao, Lingtong Hao, Qingjian Chen, Qiang Gong, Dafei Wu, Wenjie Li, Wenming Zhao, Xiuyun Tian, Chunyi Hao, Eric A. Hungate, Daniel V. T. Catenacci, Richard R. Hudson, Wen-Hsiung Li, Xuemei Lu, and Chung-I WuPNAS November 24, 2015 112 (47) E6496-E6505; first published November 11, 2015. https://doi.org/10.1073/pnas.1519556112
Genetics
- You have accessXist imprinting is promoted by the hemizygous (unpaired) state in the male germ line
- From the Cover
- Inaugural Article
Sha Sun, Bernhard Payer, Satoshi Namekawa, Jee Young An, William Press, Jovani Catalan-Dibene, Hongjae Sunwoo, and Jeannie T. LeePNAS November 24, 2015 112 (47) 14415-14422; first published October 21, 2015. https://doi.org/10.1073/pnas.1519528112See companion article:
- QnAs with Jeannie T. Lee- Nov 18, 2015
See companion article:
- Imprinted X inactivation and hemizygosity converge- Nov 17, 2015
- Open AccessPolymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus loadPaul J. McLaren, Cedric Coulonges, István Bartha, Tobias L. Lenz, Aaron J. Deutsch, Arman Bashirova, Susan Buchbinder, Mary N. Carrington, Andrea Cossarizza, Judith Dalmau, Andrea De Luca, James J. Goedert, Deepti Gurdasani, David W. Haas, Joshua T. Herbeck, Eric O. Johnson, Gregory D. Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M. Miro, James I. Mullins, Niels Obel, Guido Poli, Manjinder S. Sandhu, Hanneke Schuitemaker, Patrick R. Shea, Ioannis Theodorou, Bruce D. Walker, Amy C. Weintrob, Cheryl A. Winkler, Steven M. Wolinsky, Soumya Raychaudhuri, David B. Goldstein, Amalio Telenti, Paul I. W. de Bakker, Jean-François Zagury, and Jacques FellayPNAS November 24, 2015 112 (47) 14658-14663; first published November 9, 2015. https://doi.org/10.1073/pnas.1514867112
Immunology and Inflammation
- You have accessEngineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imagingRoy L. Maute, Sydney R. Gordon, Aaron T. Mayer, Melissa N. McCracken, Arutselvan Natarajan, Nan Guo Ring, Richard Kimura, Jonathan M. Tsai, Aashish Manglik, Andrew C. Kruse, Sanjiv S. Gambhir, Irving L. Weissman, and Aaron M. RingPNAS November 24, 2015 112 (47) E6506-E6514; first published November 10, 2015. https://doi.org/10.1073/pnas.1519623112
- You have accessAn extracatalytic function of CD45 in B cells is mediated by CD22Sarah Coughlin, Mark Noviski, James L. Mueller, Ammarina Chuwonpad, William C. Raschke, Arthur Weiss, and Julie ZikhermanPNAS November 24, 2015 112 (47) E6515-E6524; first published November 11, 2015. https://doi.org/10.1073/pnas.1519925112
- You have accessDendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cellsAnand K. Katakam, Hans Brightbill, Christian Franci, Chung Kung, Victor Nunez, Charles Jones III, Ivan Peng, Surinder Jeet, Lawren C. Wu, Ira Mellman, Lélia Delamarre, and Cary D. AustinPNAS November 24, 2015 112 (47) 14664-14669; first published November 11, 2015. https://doi.org/10.1073/pnas.1520627112
Medical Sciences
- You have accessTargeting CD146 with a 64Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomasYunan Yang, Reinier Hernandez, Jun Rao, Li Yin, Yazhuo Qu, Jinrong Wu, Christopher G. England, Stephen A. Graves, Christina M. Lewis, Pu Wang, Mary E. Meyerand, Robert J. Nickles, Xiu-wu Bian, and Weibo CaiPNAS November 24, 2015 112 (47) E6525-E6534; first published November 9, 2015. https://doi.org/10.1073/pnas.1502648112
- You have accessLeukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritisSeong-Hye Hwang, Seung-Hyun Jung, Saseong Lee, Susanna Choi, Seung-Ah Yoo, Ji-Hwan Park, Daehee Hwang, Seung Cheol Shim, Laurent Sabbagh, Ki-Jo Kim, Sung Hwan Park, Chul-Soo Cho, Bong-Sung Kim, Lin Leng, Ruth R. Montgomery, Richard Bucala, Yeun-Jun Chung, and Wan-Uk KimPNAS November 24, 2015 112 (47) E6535-E6543; first published November 9, 2015. https://doi.org/10.1073/pnas.1514152112
- Open AccessA basal stem cell signature identifies aggressive prostate cancer phenotypesBryan A. Smith, Artem Sokolov, Vladislav Uzunangelov, Robert Baertsch, Yulia Newton, Kiley Graim, Colleen Mathis, Donghui Cheng, Joshua M. Stuart, and Owen N. WittePNAS November 24, 2015 112 (47) E6544-E6552; first published October 12, 2015. https://doi.org/10.1073/pnas.1518007112
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- Neuroendocrine stem-like prostate tumors- Nov 17, 2015
- You have accessNoninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNAAi-hua Yin, Chun-fang Peng, Xin Zhao, Bennett A. Caughey, Jie-xia Yang, Jian Liu, Wei-wei Huang, Chang Liu, Dong-hong Luo, Hai-liang Liu, Yang-yi Chen, Jing Wu, Rui Hou, Mindy Zhang, Michael Ai, Lianghong Zheng, Rachel Q. Xue, Ming-qin Mai, Fang-fang Guo, Yi-ming Qi, Dong-mei Wang, Michal Krawczyk, Daniel Zhang, Yu-nan Wang, Quan-fei Huang, Michael Karin, and Kang ZhangPNAS November 24, 2015 112 (47) 14670-14675; first published November 9, 2015. https://doi.org/10.1073/pnas.1518151112
- You have accessAnti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma modelXing Gao, Yingchao Zhao, Anat O. Stemmer-Rachamimov, Hao Liu, Peigen Huang, ShanMin Chin, Martin K. Selig, Scott R. Plotkin, Rakesh K. Jain, and Lei XuPNAS November 24, 2015 112 (47) 14676-14681; first published November 9, 2015. https://doi.org/10.1073/pnas.1512570112
Microbiology
- Open AccessVirion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile virusesAudrey Stéphanie Richard, Adam Zhang, Sun-Jin Park, Michael Farzan, Min Zong, and Hyeryun ChoePNAS November 24, 2015 112 (47) 14682-14687; first published November 2, 2015. https://doi.org/10.1073/pnas.1508095112
- Open AccessAsymptomatic humans transmit dengue virus to mosquitoesVeasna Duong, Louis Lambrechts, Richard E. Paul, Sowath Ly, Rath Srey Lay, Kanya C. Long, Rekol Huy, Arnaud Tarantola, Thomas W. Scott, Anavaj Sakuntabhai, and Philippe BuchyPNAS November 24, 2015 112 (47) 14688-14693; first published November 9, 2015. https://doi.org/10.1073/pnas.1508114112
Neuroscience
- You have accessA 3′ untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuRJoshua A. Suhl, Ravi S. Muddashetty, Bart R. Anderson, Marius F. Ifrim, Jeannie Visootsak, Gary J. Bassell, and Stephen T. WarrenPNAS November 24, 2015 112 (47) E6553-E6561; first published November 9, 2015. https://doi.org/10.1073/pnas.1514260112
- Open AccessIntrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycleChristian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, and Dietmar PlenzPNAS November 24, 2015 112 (47) 14694-14699; first published November 9, 2015. https://doi.org/10.1073/pnas.1513716112
- You have accessOptimal directional volatile transport in retronasal olfactionRui Ni, Mark H. Michalski, Elliott Brown, Ngoc Doan, Joseph Zinter, Nicholas T. Ouellette, and Gordon M. ShepherdPNAS November 24, 2015 112 (47) 14700-14704; first published November 9, 2015. https://doi.org/10.1073/pnas.1511495112
- You have accessAgonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flowKim Dore, Jonathan Aow, and Roberto MalinowPNAS November 24, 2015 112 (47) 14705-14710; first published November 9, 2015. https://doi.org/10.1073/pnas.1520023112
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- Conformational signaling by the NMDAR complex- Nov 09, 2015
- You have accessConformational signaling required for synaptic plasticity by the NMDA receptor complexJonathan Aow, Kim Dore, and Roberto MalinowPNAS November 24, 2015 112 (47) 14711-14716; first published November 9, 2015. https://doi.org/10.1073/pnas.1520029112
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- Measurement of NMDA receptor metabotropic function- Nov 09, 2015
- You have accessWhole-agent selectivity within the macaque face-processing system
- From the Cover
Clark Fisher and Winrich A. FreiwaldPNAS November 24, 2015 112 (47) 14717-14722; first published October 13, 2015. https://doi.org/10.1073/pnas.1512378112See companion article:
- Head to toe, in the head- Nov 23, 2015
- You have accessUnmyelinated type II afferent neurons report cochlear damageChang Liu, Elisabeth Glowatzki, and Paul Albert FuchsPNAS November 24, 2015 112 (47) 14723-14727; first published November 9, 2015. https://doi.org/10.1073/pnas.1515228112
Pharmacology
- Open AccessSigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelopeShang-Yi A. Tsai, Jian-Ying Chuang, Meng-Shan Tsai, Xiao-fei Wang, Zheng-Xiong Xi, Jan-Jong Hung, Wen-Chang Chang, Antonello Bonci, and Tsung-Ping SuPNAS November 24, 2015 112 (47) E6562-E6570; first published November 9, 2015. https://doi.org/10.1073/pnas.1518894112
Plant Biology
- You have accessA vacuolar phosphate transporter essential for phosphate homeostasis in ArabidopsisJinlong Liu, Lei Yang, Mingda Luan, Yuan Wang, Chi Zhang, Bin Zhang, Jisen Shi, Fu-Geng Zhao, Wenzhi Lan, and Sheng LuanPNAS November 24, 2015 112 (47) E6571-E6578; first published November 9, 2015. https://doi.org/10.1073/pnas.1514598112
- You have accessRNA-directed DNA methylation enforces boundaries between heterochromatin and euchromatin in the maize genomeQing Li, Jonathan I. Gent, Greg Zynda, Jawon Song, Irina Makarevitch, Cory D. Hirsch, Candice N. Hirsch, R. Kelly Dawe, Thelma F. Madzima, Karen M. McGinnis, Damon Lisch, Robert J. Schmitz, Matthew W. Vaughn, and Nathan M. SpringerPNAS November 24, 2015 112 (47) 14728-14733; first published November 9, 2015. https://doi.org/10.1073/pnas.1514680112
- You have accessQQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactionsLing Li, Wenguang Zheng, Yanbing Zhu, Huaxun Ye, Buyun Tang, Zebulun W. Arendsee, Dallas Jones, Ruoran Li, Diego Ortiz, Xuefeng Zhao, Chuanlong Du, Dan Nettleton, M. Paul Scott, Maria G. Salas-Fernandez, Yanhai Yin, and Eve Syrkin WurtelePNAS November 24, 2015 112 (47) 14734-14739; first published November 9, 2015. https://doi.org/10.1073/pnas.1514670112
Psychological and Cognitive Sciences
- Open AccessHuman emotions track changes in the acoustic environmentWeiyi Ma and William Forde ThompsonPNAS November 24, 2015 112 (47) 14563-14568; first published November 9, 2015. https://doi.org/10.1073/pnas.1515087112
Systems Biology
- Open AccessCircadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liverFlorian Atger, Cédric Gobet, Julien Marquis, Eva Martin, Jingkui Wang, Benjamin Weger, Grégory Lefebvre, Patrick Descombes, Felix Naef, and Frédéric GachonPNAS November 24, 2015 112 (47) E6579-E6588; first published November 9, 2015. https://doi.org/10.1073/pnas.1515308112
Corrections (Online Only)
- You have accessCorrection for O’Dwyer et al., Backbones of evolutionary history test biodiversity theory for microbesPNAS November 24, 2015 112 (47) E6589; first published November 9, 2015. https://doi.org/10.1073/pnas.1520755112
- You have accessCorrection for Rasmussen et al., Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla–Wagner modelPNAS November 24, 2015 112 (47) E6590; first published November 16, 2015. https://doi.org/10.1073/pnas.1521346112
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