Proceedings of the National Academy of Sciences: 112 (47)

New Research In

November 24, 2015; vol. 112 no. 47

This Week in PNAS

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In This Issue
PNAS November 24, 2015 112 (47) 14397-14398; https://doi.org/10.1073/iti4715112

Letters (Online Only)

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Genetics of alcohol use disorders: Actin gets into the act
Golo Kronenberg, Matthias Endres, and Karen Gertz

PNAS November 24, 2015 112 (47) E6411; published ahead of print October 29, 2015. https://doi.org/10.1073/pnas.1514716112
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Distinguishing phases of biomedical research is critical to improving health outcomes
Kevin Fiscella

PNAS November 24, 2015 112 (47) E6412; published ahead of print November 10, 2015. https://doi.org/10.1073/pnas.1518862112
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Reply to Fiscella: The phases of biomedical research should be studied to optimize health outcomes
Anthony Bowen and Arturo Casadevall

PNAS November 24, 2015 112 (47) E6413; published ahead of print November 10, 2015. https://doi.org/10.1073/pnas.1519759112
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Vaginal microbiota during pregnancy: Pathways of risk of preterm delivery in the absence of intrauterine infection?
Jeffrey A. Keelan and Matthew S. Payne

PNAS November 24, 2015 112 (47) E6414; published ahead of print October 29, 2015. https://doi.org/10.1073/pnas.1517346112
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Reply to Keelan and Payne: Microbiota-related pathways for preterm birth
Daniel B. DiGiulio, David K. Stevenson, Gary Shaw, Deirdre J. Lyell, and David A. Relman

PNAS November 24, 2015 112 (47) E6415; published ahead of print October 29, 2015. https://doi.org/10.1073/pnas.1517939112

News Feature

An in-depth look at trending science issues.

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News Feature: How online studies are transforming psychology research
Front Matter
Amber Dance

PNAS November 24, 2015 112 (47) 14399-14401; https://doi.org/10.1073/pnas.1520769112

Commentaries

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Managing variance: Key policy challenges for the Anthropocene
John M. Anderies

PNAS November 24, 2015 112 (47) 14402-14403; published ahead of print November 17, 2015. https://doi.org/10.1073/pnas.1519071112
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Predictive model of 3D domain formation via CTCF-mediated extrusion
Galip Gürkan Yardımcı and William Stafford Noble

PNAS November 24, 2015 112 (47) 14404-14405; published ahead of print November 13, 2015. https://doi.org/10.1073/pnas.1519849112
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Advanced neuroendocrine prostate tumors regress to stemness
Leigh Ellis and Massimo Loda

PNAS November 24, 2015 112 (47) 14406-14407; published ahead of print November 17, 2015. https://doi.org/10.1073/pnas.1519151112
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Imprinted X chromosome inactivation offers up a double dose of epigenetics
Nora Engel

PNAS November 24, 2015 112 (47) 14408-14409; published ahead of print November 17, 2015. https://doi.org/10.1073/pnas.1520097112
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Penciling in details of the Hadean
Christopher H. House

PNAS November 24, 2015 112 (47) 14410-14411; published ahead of print November 12, 2015. https://doi.org/10.1073/pnas.1519765112

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS November 24, 2015 112 (47) 14412-14414; https://doi.org/10.1073/pnas.ss11247

The Engineering of Biology and Medicine PNAS 100th Anniversary Special Feature (Free Online)

Introduction
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  The Engineering of Biology and Medicine
  From the Cover
  
  Mark E. Davis and Robert Langer
  
  PNAS November 24, 2015 112 (47) 14423; https://doi.org/10.1073/pnas.1517450112
Perspectives
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  Advancing biomedical imaging
  Ralph Weissleder and Matthias Nahrendorf
  
  PNAS November 24, 2015 112 (47) 14424-14428; https://doi.org/10.1073/pnas.1508524112
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  Synthetic biology devices for in vitro and in vivo diagnostics
  Shimyn Slomovic, Keith Pardee, and James J. Collins
  
  PNAS November 24, 2015 112 (47) 14429-14435; https://doi.org/10.1073/pnas.1508521112
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  Nanotechnologies for biomedical science and translational medicine
  James R. Heath
  
  PNAS November 24, 2015 112 (47) 14436-14443; https://doi.org/10.1073/pnas.1515202112
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  Progress in material design for biomedical applications
  Mark W. Tibbitt, Christopher B. Rodell, Jason A. Burdick, and Kristi S. Anseth
  
  PNAS November 24, 2015 112 (47) 14444-14451; https://doi.org/10.1073/pnas.1516247112
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  Regenerative medicine: Current therapies and future directions
  Angelo S. Mao and David J. Mooney
  
  PNAS November 24, 2015 112 (47) 14452-14459; https://doi.org/10.1073/pnas.1508520112
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  Smart nanosystems: Bio-inspired technologies that interact with the host environment
  Ester J. Kwon, Justin H. Lo, and Sangeeta N. Bhatia
  
  PNAS November 24, 2015 112 (47) 14460-14466; published ahead of print November 23, 2015. https://doi.org/10.1073/pnas.1508522112
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  Engineering opportunities in cancer immunotherapy
  Laura Jeanbart and Melody A. Swartz
  
  PNAS November 24, 2015 112 (47) 14467-14472; https://doi.org/10.1073/pnas.1508516112

Physical Sciences

Applied Mathematics
- Open Access
  Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
  Adrian L. Sanborn, Suhas S. P. Rao, Su-Chen Huang, Neva C. Durand, Miriam H. Huntley, Andrew I. Jewett, Ivan D. Bochkov, Dharmaraj Chinnappan, Ashok Cutkosky, Jian Li, Kristopher P. Geeting, Andreas Gnirke, Alexandre Melnikov, Doug McKenna, Elena K. Stamenova, Eric S. Lander, and Erez Lieberman Aiden
  
  PNAS November 24, 2015 112 (47) E6456-E6465; published ahead of print October 23, 2015. https://doi.org/10.1073/pnas.1518552112
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  Accurate estimation of influenza epidemics using Google search data via ARGO
  Shihao Yang, Mauricio Santillana, and S. C. Kou
  
  PNAS November 24, 2015 112 (47) 14473-14478; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1515373112
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  Choosing experiments to accelerate collective discovery
  Andrey Rzhetsky, Jacob G. Foster, Ian T. Foster, and James A. Evans
  
  PNAS November 24, 2015 112 (47) 14569-14574; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1509757112
- Open Access
  Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle
  Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, and Dietmar Plenz
  
  PNAS November 24, 2015 112 (47) 14694-14699; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1513716112
Applied Physical Sciences
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  Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules
  Peter J. Chung, Myung Chul Choi, Herbert P. Miller, H. Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C. Feinstein, and Cyrus R. Safinya
  
  PNAS November 24, 2015 112 (47) E6416-E6425; published ahead of print November 5, 2015. https://doi.org/10.1073/pnas.1513172112
- Open Access
  Mapping transient electric fields with picosecond electron bunches
  Long Chen, Runze Li, Jie Chen, Pengfei Zhu, Feng Liu, Jianming Cao, Zhengming Sheng, and Jie Zhang
  
  PNAS November 24, 2015 112 (47) 14479-14483; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1518353112
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  Self-assembly of smallest magnetic particles
  Sara Mehdizadeh Taheri, Maria Michaelis, Thomas Friedrich, Beate Förster, Markus Drechsler, Florian M. Römer, Peter Bösecke, Theyencheri Narayanan, Birgit Weber, Ingo Rehberg, Sabine Rosenfeldt, and Stephan Förster
  
  PNAS November 24, 2015 112 (47) 14484-14489; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1511443112
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  Wetting and phase separation in soft adhesion
  Katharine E. Jensen, Raphael Sarfati, Robert W. Style, Rostislav Boltyanskiy, Aditi Chakrabarti, Manoj K. Chaudhury, and Eric R. Dufresne
  
  PNAS November 24, 2015 112 (47) 14490-14494; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514378112
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  Topological mechanics of gyroscopic metamaterials
  Lisa M. Nash, Dustin Kleckner, Alismari Read, Vincenzo Vitelli, Ari M. Turner, and William T. M. Irvine
  
  PNAS November 24, 2015 112 (47) 14495-14500; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1507413112
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  Heterogeneous lamella structure unites ultrafine-grain strength with coarse-grain ductility
  Xiaolei Wu, Muxin Yang, Fuping Yuan, Guilin Wu, Yujie Wei, Xiaoxu Huang, and Yuntian Zhu
  
  PNAS November 24, 2015 112 (47) 14501-14505; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1517193112
Chemistry
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  Electrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzyme
  Hope Adamson, Alexandr N. Simonov, Michelina Kierzek, Richard A. Rothery, Joel H. Weiner, Alan M. Bond, and Alison Parkin
  
  PNAS November 24, 2015 112 (47) 14506-14511; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1516869112
Earth, Atmospheric, and Planetary Sciences
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  Shifts in coral reef biogeochemistry and resulting acidification linked to offshore productivity
  Kiley L. Yeakel, Andreas J. Andersson, Nicholas R. Bates, Timothy J. Noyes, Andrew Collins, and Rebecca Garley
  
  PNAS November 24, 2015 112 (47) 14512-14517; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1507021112
- Open Access
  Potentially biogenic carbon preserved in a 4.1 billion-year-old zircon
  From the Cover
  
  Elizabeth A. Bell, Patrick Boehnke, T. Mark Harrison, and Wendy L. Mao
  
  PNAS November 24, 2015 112 (47) 14518-14521; published ahead of print October 19, 2015. https://doi.org/10.1073/pnas.1517557112
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  Dynamic response of desert wetlands to abrupt climate change
  Kathleen B. Springer, Craig R. Manker, and Jeffrey S. Pigati
  
  PNAS November 24, 2015 112 (47) 14522-14526; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1513352112
Engineering
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  Ultrasensitive gas detection of large-area boron-doped graphene
  Ruitao Lv, Gugang Chen, Qing Li, Amber McCreary, Andrés Botello-Méndez, S. V. Morozov, Liangbo Liang, Xavier Declerck, Nestor Perea-López, David A. Cullen, Simin Feng, Ana Laura Elías, Rodolfo Cruz-Silva, Kazunori Fujisawa, Morinobu Endo, Feiyu Kang, Jean-Christophe Charlier, Vincent Meunier, Minghu Pan, Avetik R. Harutyunyan, Konstantin S. Novoselov, and Mauricio Terrones
  
  PNAS November 24, 2015 112 (47) 14527-14532; published ahead of print November 2, 2015. https://doi.org/10.1073/pnas.1505993112
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  Ultraflexible, large-area, physiological temperature sensors for multipoint measurements
  Tomoyuki Yokota, Yusuke Inoue, Yuki Terakawa, Jonathan Reeder, Martin Kaltenbrunner, Taylor Ware, Kejia Yang, Kunihiko Mabuchi, Tomohiro Murakawa, Masaki Sekino, Walter Voit, Tsuyoshi Sekitani, and Takao Someya
  
  PNAS November 24, 2015 112 (47) 14533-14538; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1515650112
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  Optimal directional volatile transport in retronasal olfaction
  Rui Ni, Mark H. Michalski, Elliott Brown, Ngoc Doan, Joseph Zinter, Nicholas T. Ouellette, and Gordon M. Shepherd
  
  PNAS November 24, 2015 112 (47) 14700-14704; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1511495112
Physics
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  Universal spectrum of normal modes in low-temperature glasses
  Silvio Franz, Giorgio Parisi, Pierfrancesco Urbani, and Francesco Zamponi
  
  PNAS November 24, 2015 112 (47) 14539-14544; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1511134112
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  Deformation and failure of curved colloidal crystal shells
  Carlotta Negri, Alessandro L. Sellerio, Stefano Zapperi, and M. Carmen Miguel
  
  PNAS November 24, 2015 112 (47) 14545-14550; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1518258112
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  Filling constraints for spin-orbit coupled insulators in symmorphic and nonsymmorphic crystals
  Haruki Watanabe, Hoi Chun Po, Ashvin Vishwanath, and Michael Zaletel
  
  PNAS November 24, 2015 112 (47) 14551-14556; published ahead of print November 10, 2015. https://doi.org/10.1073/pnas.1514665112

Biological Sciences

Applied Biological Sciences
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  Mapping landscape friction to locate isolated tsetse populations that are candidates for elimination
  Jérémy Bouyer, Ahmadou H. Dicko, Giuliano Cecchi, Sophie Ravel, Laure Guerrini, Philippe Solano, Marc J. B. Vreysen, Thierry De Meeûs, and Renaud Lancelot
  
  PNAS November 24, 2015 112 (47) 14575-14580; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1516778112
Biochemistry
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  Conserved interdomain linker promotes phase separation of the multivalent adaptor protein Nck
  Sudeep Banjade, Qiong Wu, Anuradha Mittal, William B. Peeples, Rohit V. Pappu, and Michael K. Rosen
  
  PNAS November 24, 2015 112 (47) E6426-E6435; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1508778112
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  Allosteric N-WASP activation by an inter-SH3 domain linker in Nck
  Julia Okrut, Sumit Prakash, Qiong Wu, Mark J. S. Kelly, and Jack Taunton
  
  PNAS November 24, 2015 112 (47) E6436-E6445; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1510876112
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  Global shape mimicry of tRNA within a viral internal ribosome entry site mediates translational reading frame selection
  Hilda H. Au, Gabriel Cornilescu, Kathryn D. Mouzakis, Qian Ren, Jordan E. Burke, Seonghoon Lee, Samuel E. Butcher, and Eric Jan
  
  PNAS November 24, 2015 112 (47) E6446-E6455; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1512088112
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  Electrochemical evidence that pyranopterin redox chemistry controls the catalysis of YedY, a mononuclear Mo enzyme
  Hope Adamson, Alexandr N. Simonov, Michelina Kierzek, Richard A. Rothery, Joel H. Weiner, Alan M. Bond, and Alison Parkin
  
  PNAS November 24, 2015 112 (47) 14506-14511; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1516869112
- Open Access
  Guanine-vacancy–bearing G-quadruplexes responsive to guanine derivatives
  Xin-min Li, Ke-wei Zheng, Jia-yu Zhang, Hong-he Liu, Yi-de He, Bi-feng Yuan, Yu-hua Hao, and Zheng Tan
  
  PNAS November 24, 2015 112 (47) 14581-14586; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1516925112
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  FOXO regulates RNA interference in Drosophila and protects from RNA virus infection
  Michael J. Spellberg and Michael T. Marr II
  
  PNAS November 24, 2015 112 (47) 14587-14592; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1517124112
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  Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V
  Darshan V. Trivedi, Joseph M. Muretta, Anja M. Swenson, Jonathon P. Davis, David D. Thomas, and Christopher M. Yengo
  
  PNAS November 24, 2015 112 (47) 14593-14598; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1517566112
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  Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
  Andrew R. Buller, Sabine Brinkmann-Chen, David K. Romney, Michael Herger, Javier Murciano-Calles, and Frances H. Arnold
  
  PNAS November 24, 2015 112 (47) 14599-14604; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1516401112
Biophysics and Computational Biology
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  Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules
  Peter J. Chung, Myung Chul Choi, Herbert P. Miller, H. Eric Feinstein, Uri Raviv, Youli Li, Leslie Wilson, Stuart C. Feinstein, and Cyrus R. Safinya
  
  PNAS November 24, 2015 112 (47) E6416-E6425; published ahead of print November 5, 2015. https://doi.org/10.1073/pnas.1513172112
- Open Access
  Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
  Adrian L. Sanborn, Suhas S. P. Rao, Su-Chen Huang, Neva C. Durand, Miriam H. Huntley, Andrew I. Jewett, Ivan D. Bochkov, Dharmaraj Chinnappan, Ashok Cutkosky, Jian Li, Kristopher P. Geeting, Andreas Gnirke, Alexandre Melnikov, Doug McKenna, Elena K. Stamenova, Eric S. Lander, and Erez Lieberman Aiden
  
  PNAS November 24, 2015 112 (47) E6456-E6465; published ahead of print October 23, 2015. https://doi.org/10.1073/pnas.1518552112
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  Designed protein reveals structural determinants of extreme kinetic stability
  Aron Broom, S. Martha Ma, Ke Xia, Hitesh Rafalia, Kyle Trainor, Wilfredo Colón, Shachi Gosavi, and Elizabeth M. Meiering
  
  PNAS November 24, 2015 112 (47) 14605-14610; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1510748112
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  Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy
  Si Yan, Changmiao Guo, Guangjin Hou, Huilan Zhang, Xingyu Lu, John Charles Williams, and Tatyana Polenova
  
  PNAS November 24, 2015 112 (47) 14611-14616; published ahead of print November 10, 2015. https://doi.org/10.1073/pnas.1509852112
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  Dynamic allostery governs cyclophilin A–HIV capsid interplay
  Manman Lu, Guangjin Hou, Huilan Zhang, Christopher L. Suiter, Jinwoo Ahn, In-Ja L. Byeon, Juan R. Perilla, Christopher J. Langmead, Ivan Hung, Peter L. Gor'kov, Zhehong Gan, William Brey, Christopher Aiken, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, and Tatyana Polenova
  
  PNAS November 24, 2015 112 (47) 14617-14622; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1516920112
Cell Biology
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  HAX-1 regulates cyclophilin-D levels and mitochondria permeability transition pore in the heart
  Chi Keung Lam, Wen Zhao, Guan-Sheng Liu, Wen-Feng Cai, George Gardner, George Adly, and Evangelia G. Kranias
  
  PNAS November 24, 2015 112 (47) E6466-E6475; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1508760112
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  Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma
  Narayana Yeddula, Yifeng Xia, Eugene Ke, Joep Beumer, and Inder M. Verma
  
  PNAS November 24, 2015 112 (47) E6476-E6485; published ahead of print November 5, 2015. https://doi.org/10.1073/pnas.1520110112
- Open Access
  TRPC6 channel translocation into phagosomal membrane augments phagosomal function
  Vladimir Riazanski, Aida G. Gabdoulkhakova, Lin S. Boynton, Raphael R. Eguchi, Ludmila V. Deriy, D. Kyle Hogarth, Nadège Loaëc, Nassima Oumata, Hervé Galons, Mary E. Brown, Pavel Shevchenko, Alexander J. Gallan, Sang Gune Yoo, Anjaparavanda P. Naren, Mitchel L. Villereal, Daniel W. Beacham, Vytautas P. Bindokas, Lutz Birnbaumer, Laurent Meijer, and Deborah J. Nelson
  
  PNAS November 24, 2015 112 (47) E6486-E6495; published ahead of print November 10, 2015. https://doi.org/10.1073/pnas.1518966112
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  A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation
  Christoffer K. Goth, Adnan Halim, Sumeet A. Khetarpal, Daniel J. Rader, Henrik Clausen, and Katrine T.-B. G. Schjoldager
  
  PNAS November 24, 2015 112 (47) 14623-14628; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1511175112
Developmental Biology
- Open Access
  Fourteen babies born after round spermatid injection into human oocytes
  Atsushi Tanaka, Motoi Nagayoshi, Youichi Takemoto, Izumi Tanaka, Hiroshi Kusunoki, Seiji Watanabe, Keiji Kuroda, Satoru Takeda, Masahiko Ito, and Ryuzo Yanagimachi
  
  PNAS November 24, 2015 112 (47) 14629-14634; published ahead of print November 2, 2015. https://doi.org/10.1073/pnas.1517466112
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  Superresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes
  Kirti Prakash, David Fournier, Stefan Redl, Gerrit Best, Máté Borsos, Vijay K. Tiwari, Kikuë Tachibana-Konwalski, René F. Ketting, Sapun H. Parekh, Christoph Cremer, and Udo J. Birk
  
  PNAS November 24, 2015 112 (47) 14635-14640; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1516928112
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  Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons
  Yuki Hatanaka, Kimiko Inoue, Mami Oikawa, Satoshi Kamimura, Narumi Ogonuki, Eiichi N. Kodama, Yasuyuki Ohkawa, Yu-ichi Tsukada, and Atsuo Ogura
  
  PNAS November 24, 2015 112 (47) 14641-14646; published ahead of print November 6, 2015. https://doi.org/10.1073/pnas.1512775112
Environmental Sciences
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  Shifts in coral reef biogeochemistry and resulting acidification linked to offshore productivity
  Kiley L. Yeakel, Andreas J. Andersson, Nicholas R. Bates, Timothy J. Noyes, Andrew Collins, and Rebecca Garley
  
  PNAS November 24, 2015 112 (47) 14512-14517; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1507021112
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  Redistribution of soil water by a saprotrophic fungus enhances carbon mineralization
  Alexander Guhr, Werner Borken, Marie Spohn, and Egbert Matzner
  
  PNAS November 24, 2015 112 (47) 14647-14651; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514435112
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  Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton
  Hugo Botebol, Emmanuel Lesuisse, Robert Šuták, Christophe Six, Jean-Claude Lozano, Philippe Schatt, Valérie Vergé, Amos Kirilovsky, Joe Morrissey, Thibaut Léger, Jean-Michel Camadro, Audrey Gueneugues, Chris Bowler, Stéphane Blain, and François-Yves Bouget
  
  PNAS November 24, 2015 112 (47) 14652-14657; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1506074112
Evolution
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  Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution
  Shaoping Ling, Zheng Hu, Zuyu Yang, Fang Yang, Yawei Li, Pei Lin, Ke Chen, Lili Dong, Lihua Cao, Yong Tao, Lingtong Hao, Qingjian Chen, Qiang Gong, Dafei Wu, Wenjie Li, Wenming Zhao, Xiuyun Tian, Chunyi Hao, Eric A. Hungate, Daniel V. T. Catenacci, Richard R. Hudson, Wen-Hsiung Li, Xuemei Lu, and Chung-I Wu
  
  PNAS November 24, 2015 112 (47) E6496-E6505; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1519556112
Genetics
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  Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line
  From the Cover
  
  Inaugural Article
  
  Sha Sun, Bernhard Payer, Satoshi Namekawa, Jee Young An, William Press, Jovani Catalan-Dibene, Hongjae Sunwoo, and Jeannie T. Lee
  
  PNAS November 24, 2015 112 (47) 14415-14422; published ahead of print October 21, 2015. https://doi.org/10.1073/pnas.1519528112
- Open Access
  Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load
  Paul J. McLaren, Cedric Coulonges, István Bartha, Tobias L. Lenz, Aaron J. Deutsch, Arman Bashirova, Susan Buchbinder, Mary N. Carrington, Andrea Cossarizza, Judith Dalmau, Andrea De Luca, James J. Goedert, Deepti Gurdasani, David W. Haas, Joshua T. Herbeck, Eric O. Johnson, Gregory D. Kirk, Olivier Lambotte, Ma Luo, Simon Mallal, Daniëlle van Manen, Javier Martinez-Picado, Laurence Meyer, José M. Miro, James I. Mullins, Niels Obel, Guido Poli, Manjinder S. Sandhu, Hanneke Schuitemaker, Patrick R. Shea, Ioannis Theodorou, Bruce D. Walker, Amy C. Weintrob, Cheryl A. Winkler, Steven M. Wolinsky, Soumya Raychaudhuri, David B. Goldstein, Amalio Telenti, Paul I. W. de Bakker, Jean-François Zagury, and Jacques Fellay
  
  PNAS November 24, 2015 112 (47) 14658-14663; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514867112
Immunology and Inflammation
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  Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging
  Roy L. Maute, Sydney R. Gordon, Aaron T. Mayer, Melissa N. McCracken, Arutselvan Natarajan, Nan Guo Ring, Richard Kimura, Jonathan M. Tsai, Aashish Manglik, Andrew C. Kruse, Sanjiv S. Gambhir, Irving L. Weissman, and Aaron M. Ring
  
  PNAS November 24, 2015 112 (47) E6506-E6514; published ahead of print November 10, 2015. https://doi.org/10.1073/pnas.1519623112
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  An extracatalytic function of CD45 in B cells is mediated by CD22
  Sarah Coughlin, Mark Noviski, James L. Mueller, Ammarina Chuwonpad, William C. Raschke, Arthur Weiss, and Julie Zikherman
  
  PNAS November 24, 2015 112 (47) E6515-E6524; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1519925112
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  Dendritic cells require NIK for CD40-dependent cross-priming of CD8⁺ T cells
  Anand K. Katakam, Hans Brightbill, Christian Franci, Chung Kung, Victor Nunez, Charles Jones III, Ivan Peng, Surinder Jeet, Lawren C. Wu, Ira Mellman, Lélia Delamarre, and Cary D. Austin
  
  PNAS November 24, 2015 112 (47) 14664-14669; published ahead of print November 11, 2015. https://doi.org/10.1073/pnas.1520627112
Medical Sciences
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  Targeting CD146 with a ⁶⁴Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas
  Yunan Yang, Reinier Hernandez, Jun Rao, Li Yin, Yazhuo Qu, Jinrong Wu, Christopher G. England, Stephen A. Graves, Christina M. Lewis, Pu Wang, Mary E. Meyerand, Robert J. Nickles, Xiu-wu Bian, and Weibo Cai
  
  PNAS November 24, 2015 112 (47) E6525-E6534; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1502648112
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  Leukocyte-specific protein 1 regulates T-cell migration in rheumatoid arthritis
  Seong-Hye Hwang, Seung-Hyun Jung, Saseong Lee, Susanna Choi, Seung-Ah Yoo, Ji-Hwan Park, Daehee Hwang, Seung Cheol Shim, Laurent Sabbagh, Ki-Jo Kim, Sung Hwan Park, Chul-Soo Cho, Bong-Sung Kim, Lin Leng, Ruth R. Montgomery, Richard Bucala, Yeun-Jun Chung, and Wan-Uk Kim
  
  PNAS November 24, 2015 112 (47) E6535-E6543; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514152112
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  A basal stem cell signature identifies aggressive prostate cancer phenotypes
  Bryan A. Smith, Artem Sokolov, Vladislav Uzunangelov, Robert Baertsch, Yulia Newton, Kiley Graim, Colleen Mathis, Donghui Cheng, Joshua M. Stuart, and Owen N. Witte
  
  PNAS November 24, 2015 112 (47) E6544-E6552; published ahead of print October 12, 2015. https://doi.org/10.1073/pnas.1518007112
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  Noninvasive detection of fetal subchromosomal abnormalities by semiconductor sequencing of maternal plasma DNA
  Ai-hua Yin, Chun-fang Peng, Xin Zhao, Bennett A. Caughey, Jie-xia Yang, Jian Liu, Wei-wei Huang, Chang Liu, Dong-hong Luo, Hai-liang Liu, Yang-yi Chen, Jing Wu, Rui Hou, Mindy Zhang, Michael Ai, Lianghong Zheng, Rachel Q. Xue, Ming-qin Mai, Fang-fang Guo, Yi-ming Qi, Dong-mei Wang, Michal Krawczyk, Daniel Zhang, Yu-nan Wang, Quan-fei Huang, Michael Karin, and Kang Zhang
  
  PNAS November 24, 2015 112 (47) 14670-14675; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1518151112
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  Anti-VEGF treatment improves neurological function and augments radiation response in NF2 schwannoma model
  Xing Gao, Yingchao Zhao, Anat O. Stemmer-Rachamimov, Hao Liu, Peigen Huang, ShanMin Chin, Martin K. Selig, Scott R. Plotkin, Rakesh K. Jain, and Lei Xu
  
  PNAS November 24, 2015 112 (47) 14676-14681; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1512570112
Microbiology
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  Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue, and West Nile viruses
  Audrey Stéphanie Richard, Adam Zhang, Sun-Jin Park, Michael Farzan, Min Zong, and Hyeryun Choe
  
  PNAS November 24, 2015 112 (47) 14682-14687; published ahead of print November 2, 2015. https://doi.org/10.1073/pnas.1508095112
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  Asymptomatic humans transmit dengue virus to mosquitoes
  Veasna Duong, Louis Lambrechts, Richard E. Paul, Sowath Ly, Rath Srey Lay, Kanya C. Long, Rekol Huy, Arnaud Tarantola, Thomas W. Scott, Anavaj Sakuntabhai, and Philippe Buchy
  
  PNAS November 24, 2015 112 (47) 14688-14693; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1508114112
Neuroscience
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  A 3′ untranslated region variant in FMR1 eliminates neuronal activity-dependent translation of FMRP by disrupting binding of the RNA-binding protein HuR
  Joshua A. Suhl, Ravi S. Muddashetty, Bart R. Anderson, Marius F. Ifrim, Jeannie Visootsak, Gary J. Bassell, and Stephen T. Warren
  
  PNAS November 24, 2015 112 (47) E6553-E6561; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514260112
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  Intrinsic excitability measures track antiepileptic drug action and uncover increasing/decreasing excitability over the wake/sleep cycle
  Christian Meisel, Andreas Schulze-Bonhage, Dean Freestone, Mark James Cook, Peter Achermann, and Dietmar Plenz
  
  PNAS November 24, 2015 112 (47) 14694-14699; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1513716112
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  Optimal directional volatile transport in retronasal olfaction
  Rui Ni, Mark H. Michalski, Elliott Brown, Ngoc Doan, Joseph Zinter, Nicholas T. Ouellette, and Gordon M. Shepherd
  
  PNAS November 24, 2015 112 (47) 14700-14704; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1511495112
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  Agonist binding to the NMDA receptor drives movement of its cytoplasmic domain without ion flow
  Kim Dore, Jonathan Aow, and Roberto Malinow
  
  PNAS November 24, 2015 112 (47) 14705-14710; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1520023112
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  Conformational signaling required for synaptic plasticity by the NMDA receptor complex
  Jonathan Aow, Kim Dore, and Roberto Malinow
  
  PNAS November 24, 2015 112 (47) 14711-14716; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1520029112
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  Whole-agent selectivity within the macaque face-processing system
  From the Cover
  
  Clark Fisher and Winrich A. Freiwald
  
  PNAS November 24, 2015 112 (47) 14717-14722; published ahead of print October 13, 2015. https://doi.org/10.1073/pnas.1512378112
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  Unmyelinated type II afferent neurons report cochlear damage
  Chang Liu, Elisabeth Glowatzki, and Paul Albert Fuchs
  
  PNAS November 24, 2015 112 (47) 14723-14727; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1515228112
Pharmacology
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  Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope
  Shang-Yi A. Tsai, Jian-Ying Chuang, Meng-Shan Tsai, Xiao-fei Wang, Zheng-Xiong Xi, Jan-Jong Hung, Wen-Chang Chang, Antonello Bonci, and Tsung-Ping Su
  
  PNAS November 24, 2015 112 (47) E6562-E6570; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1518894112
Plant Biology
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  A vacuolar phosphate transporter essential for phosphate homeostasis in Arabidopsis
  Jinlong Liu, Lei Yang, Mingda Luan, Yuan Wang, Chi Zhang, Bin Zhang, Jisen Shi, Fu-Geng Zhao, Wenzhi Lan, and Sheng Luan
  
  PNAS November 24, 2015 112 (47) E6571-E6578; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514598112
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  RNA-directed DNA methylation enforces boundaries between heterochromatin and euchromatin in the maize genome
  Qing Li, Jonathan I. Gent, Greg Zynda, Jawon Song, Irina Makarevitch, Cory D. Hirsch, Candice N. Hirsch, R. Kelly Dawe, Thelma F. Madzima, Karen M. McGinnis, Damon Lisch, Robert J. Schmitz, Matthew W. Vaughn, and Nathan M. Springer
  
  PNAS November 24, 2015 112 (47) 14728-14733; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514680112
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  QQS orphan gene regulates carbon and nitrogen partitioning across species via NF-YC interactions
  Ling Li, Wenguang Zheng, Yanbing Zhu, Huaxun Ye, Buyun Tang, Zebulun W. Arendsee, Dallas Jones, Ruoran Li, Diego Ortiz, Xuefeng Zhao, Chuanlong Du, Dan Nettleton, M. Paul Scott, Maria G. Salas-Fernandez, Yanhai Yin, and Eve Syrkin Wurtele
  
  PNAS November 24, 2015 112 (47) 14734-14739; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1514670112
Psychological and Cognitive Sciences
- Open Access
  Human emotions track changes in the acoustic environment
  Weiyi Ma and William Forde Thompson
  
  PNAS November 24, 2015 112 (47) 14563-14568; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1515087112
Systems Biology
- Open Access
  Circadian and feeding rhythms differentially affect rhythmic mRNA transcription and translation in mouse liver
  Florian Atger, Cédric Gobet, Julien Marquis, Eva Martin, Jingkui Wang, Benjamin Weger, Grégory Lefebvre, Patrick Descombes, Felix Naef, and Frédéric Gachon
  
  PNAS November 24, 2015 112 (47) E6579-E6588; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1515308112

Corrections (Online Only)

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Correction for O’Dwyer et al., Backbones of evolutionary history test biodiversity theory for microbes
PNAS November 24, 2015 112 (47) E6589; published ahead of print November 9, 2015. https://doi.org/10.1073/pnas.1520755112
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Correction for Rasmussen et al., Purkinje cell activity during classical conditioning with different conditional stimulus explains central tenet of Rescorla–Wagner model
PNAS November 24, 2015 112 (47) E6590; published ahead of print November 16, 2015. https://doi.org/10.1073/pnas.1521346112

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