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Superresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes

Kirti Prakash, David Fournier, Stefan Redl, Gerrit Best, Máté Borsos, Vijay K. Tiwari, Kikuë Tachibana-Konwalski, René F. Ketting, Sapun H. Parekh, Christoph Cremer, and Udo J. Birk
PNAS November 24, 2015 112 (47) 14635-14640; published ahead of print November 11, 2015 https://doi.org/10.1073/pnas.1516928112
Kirti Prakash
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;bInstitute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany;
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  • ORCID record for Kirti Prakash
David Fournier
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;
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Stefan Redl
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;
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Gerrit Best
cDepartment of Molecular Spectroscopy, Max Planck Institute for Polymer Research, 55128 Mainz, Germany;
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Máté Borsos
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;dInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter Campus, 1030 Vienna, Austria
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Vijay K. Tiwari
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;
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Kikuë Tachibana-Konwalski
dInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter Campus, 1030 Vienna, Austria
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René F. Ketting
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;
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Sapun H. Parekh
cDepartment of Molecular Spectroscopy, Max Planck Institute for Polymer Research, 55128 Mainz, Germany;
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Christoph Cremer
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;bInstitute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany;
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  • For correspondence: c.cremer@imb-mainz.de
Udo J. Birk
aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;
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  1. Edited by Joseph G. Gall, Carnegie Institution of Washington, Baltimore, MD, and approved October 7, 2015 (received for review August 25, 2015)

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Article Information

vol. 112 no. 47 14635-14640
DOI: 
https://doi.org/10.1073/pnas.1516928112
PubMed: 
26561583

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue November 24, 2015.
  • Published first November 11, 2015.


Author Information

  1. Kirti Prakasha,b,
  2. David Fourniera,
  3. Stefan Redla,
  4. Gerrit Bestc,
  5. Máté Borsosa,d,
  6. Vijay K. Tiwaria,
  7. Kikuë Tachibana-Konwalskid,
  8. René F. Kettinga,
  9. Sapun H. Parekhc,
  10. Christoph Cremera,b,1, and
  11. Udo J. Birka
  1. aInstitute of Molecular Biology (IMB), 55128 Mainz, Germany;
  2. bInstitute for Pharmacy and Molecular Biotechnology, University of Heidelberg, 69120 Heidelberg, Germany;
  3. cDepartment of Molecular Spectroscopy, Max Planck Institute for Polymer Research, 55128 Mainz, Germany;
  4. dInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna Biocenter Campus, 1030 Vienna, Austria
  1. Edited by Joseph G. Gall, Carnegie Institution of Washington, Baltimore, MD, and approved October 7, 2015 (received for review August 25, 2015)

Footnotes

  • ↵1To whom correspondence should be addressed. Email: c.cremer{at}imb-mainz.de.
  • Author contributions: K.P. designed research; K.P. and S.R. performed research; K.P., S.R., G.B., M.B., V.K.T., K.T.-K., R.F.K., S.H.P., C.C., and U.J.B. contributed new reagents/analytic tools; K.P. and D.F. analyzed data; K.P. and D.F. wrote the paper with input from all the other authors.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1516928112/-/DCSupplemental.

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Article usage

Article usage: November 2015 to February 2019

AbstractFullPdf
Nov 20155520100652
Dec 20152420121129
Total 20157940221781
Jan 20165699072
Feb 20162997059
Mar 20161536750
Apr 20161265742
May 20161234940
Jun 20161004336
Jul 2016572936
Aug 2016773319
Sep 2016953551
Oct 2016585841
Nov 2016675440
Dec 2016383329
Total 20161762618515
Jan 2017533429
Feb 2017903836
Mar 2017594267
Apr 20177729322
May 20178138164
Jun 20174147126
Jul 2017542733
Aug 2017834223
Sep 2017462930
Oct 2017712428
Nov 2017474040
Dec 2017412518
Total 2017743415916
Jan 2018463420
Feb 2018504415
Mar 2018615035
Apr 2018634923
May 2018845439
Jun 2018562936
Jul 2018474916
Aug 2018414111
Sep 2018474221
Oct 2018176522
Nov 201876215
Dec 2018118216
Total 2018530601269
Jan 201964714
Feb 2019114016
Total 2019178730
Total1099219422511
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Epigenetic landscape of meiotic chromosomes
Kirti Prakash, David Fournier, Stefan Redl, Gerrit Best, Máté Borsos, Vijay K. Tiwari, Kikuë Tachibana-Konwalski, René F. Ketting, Sapun H. Parekh, Christoph Cremer, Udo J. Birk
Proceedings of the National Academy of Sciences Nov 2015, 112 (47) 14635-14640; DOI: 10.1073/pnas.1516928112

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Epigenetic landscape of meiotic chromosomes
Kirti Prakash, David Fournier, Stefan Redl, Gerrit Best, Máté Borsos, Vijay K. Tiwari, Kikuë Tachibana-Konwalski, René F. Ketting, Sapun H. Parekh, Christoph Cremer, Udo J. Birk
Proceedings of the National Academy of Sciences Nov 2015, 112 (47) 14635-14640; DOI: 10.1073/pnas.1516928112
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