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Table of Contents

December 29, 2015; vol. 112 no. 52

This Week in PNAS

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    In This Issue
    PNAS December 29, 2015 112 (52) 15767-15768; https://doi.org/10.1073/iti5215112

PNAS 100th Anniversary Article

  • Commentary

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      Debreu’s social equilibrium existence theorem
      Partha Sarathi Dasgupta and Eric S. Maskin
      PNAS December 29, 2015 112 (52) 15769-15770; first published December 23, 2015. https://doi.org/10.1073/pnas.1522640113

      See companion article:

      • A Social Equilibrium Existence Theorem
        - Oct 15, 1952

Letters (Online Only)

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    An alternative interpretation of the Australopithecus scapula
    Stephanie M. Melillo
    PNAS December 29, 2015 112 (52) E7159; first published December 16, 2015. https://doi.org/10.1073/pnas.1520902112
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    Reply to Melillo: Woranso-Mille is consistent with an australopithecine shoulder intermediate between African apes and Homo
    Nathan M. Young, Terence D. Capellini, Neil T. Roach, and Zeresenay Alemseged
    PNAS December 29, 2015 112 (52) E7160; first published December 16, 2015. https://doi.org/10.1073/pnas.1521824112

    See companion article:

    • Fossil hominin shoulders
      - Sep 08, 2015
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    Additive partitioning of a beta diversity index is controversial
    Youhua Chen and Dénes Schmera
    PNAS December 29, 2015 112 (52) E7161; first published December 18, 2015. https://doi.org/10.1073/pnas.1521798113
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    Reply to Chen and Schmera: Partitioning beta diversity into replacement and nestedness-resultant components is not controversial
    Kris A. Murray and Andrés Baselga
    PNAS December 29, 2015 112 (52) E7162; first published December 18, 2015. https://doi.org/10.1073/pnas.1522279113

    See companion article:

    • Global biogeography of human infectious disease
      - Sep 28, 2015
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    Is the onset of obesity the same as aging?
    Anne B. Newman
    PNAS December 29, 2015 112 (52) E7163; first published December 16, 2015. https://doi.org/10.1073/pnas.1515367112
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    Reply to Newman: Quantification of biological aging in young adults is not the same thing as the onset of obesity
    Daniel W. Belsky
    PNAS December 29, 2015 112 (52) E7164-E7165; first published December 16, 2015. https://doi.org/10.1073/pnas.1518878112

    See companion article:

    • Quantification of biological aging in young adults
      - Jul 06, 2015

Reviewer Acknowledgment (Online Only)

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    Acknowledgment of Reviewers, 2015
    PNAS December 29, 2015 112 (52) E7308-E7344; https://doi.org/10.1073/pnas.reviewers112

Inner Workings

An over-the-shoulder look at scientists at work.
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    Inner Workings: DNA for data storage and computing
    • Front Matter
    Megan Scudellari
    PNAS December 29, 2015 112 (52) 15771-15772; https://doi.org/10.1073/pnas.1520100112

Profile

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    Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine
    Wesley C. Van Voorhis, Rob Hooft van Huijsduijnen, and Timothy N. C. Wells
    PNAS December 29, 2015 112 (52) 15773-15776; first published December 22, 2015. https://doi.org/10.1073/pnas.1520952112

Commentaries

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    Energetics and population genetics at the root of eukaryotic cellular and genomic complexity
    Eugene V. Koonin
    PNAS December 29, 2015 112 (52) 15777-15778; first published December 23, 2015. https://doi.org/10.1073/pnas.1520869112

    See companion article:

    • Cost of a gene
      - Nov 02, 2015
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    Battle of sex hormones in genitalia anomalies
    Liang Ma
    PNAS December 29, 2015 112 (52) 15779-15780; first published November 23, 2015. https://doi.org/10.1073/pnas.1518491112

    See companion article:

    • Timing of AR disruption determines genital defects
      - Nov 23, 2015
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    Human behavior under economic inequality shapes inequality
    Akihiro Nishi and Nicholas A. Christakis
    PNAS December 29, 2015 112 (52) 15781-15782; first published December 16, 2015. https://doi.org/10.1073/pnas.1522090112

    See companion article:

    • Inequality, income, and generosity
      - Nov 23, 2015
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    Adopting ALK and LTK
    Greg Lemke
    PNAS December 29, 2015 112 (52) 15783-15784; first published December 16, 2015. https://doi.org/10.1073/pnas.1521923113

    See companion article:

    • Augmentor α functions as the ligand for ALK
      - Nov 16, 2015
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    Autoinflammation and autoimmunity in systemic juvenile idiopathic arthritis
    Peter A. Nigrovic
    PNAS December 29, 2015 112 (52) 15785-15786; first published December 17, 2015. https://doi.org/10.1073/pnas.1521837113

    See companion article:

    • MHC locus and risk of systemic juvenile arthritis
      - Nov 23, 2015

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS December 29, 2015 112 (52) 15787-15789; https://doi.org/10.1073/pnas.ss11252

Physical Sciences

  • Applied Physical Sciences

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      Dogs lap using acceleration-driven open pumping
      • From the Cover
      Sean Gart, John J. Socha, Pavlos P. Vlachos, and Sunghwan Jung
      PNAS December 29, 2015 112 (52) 15798-15802; first published December 14, 2015. https://doi.org/10.1073/pnas.1514842112
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      High-energy resolution X-ray absorption and emission spectroscopy reveals insight into unique selectivity of La-based nanoparticles for CO2
      Ofer Hirsch, Kristina O. Kvashnina, Li Luo, Martin J. Süess, Pieter Glatzel, and Dorota Koziej
      PNAS December 29, 2015 112 (52) 15803-15808; first published December 14, 2015. https://doi.org/10.1073/pnas.1516192113
  • Chemistry

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      Polymer-supported CuPd nanoalloy as a synergistic catalyst for electrocatalytic reduction of carbon dioxide to methane
      Sheng Zhang, Peng Kang, Mohammed Bakir, Alexander M. Lapides, Christopher J. Dares, and Thomas J. Meyer
      PNAS December 29, 2015 112 (52) 15809-15814; first published December 14, 2015. https://doi.org/10.1073/pnas.1522496112
    • Open Access
      Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer
      Jacob L. Houghton, Brian M. Zeglis, Dalya Abdel-Atti, Robert Aggeler, Ritsuko Sawada, Brian J. Agnew, Wolfgang W. Scholz, and Jason S. Lewis
      PNAS December 29, 2015 112 (52) 15850-15855; first published December 14, 2015. https://doi.org/10.1073/pnas.1506542112
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      Unveiling the crucial intermediates in androgen production
      Piotr J. Mak, Michael C. Gregory, Ilia G. Denisov, Stephen G. Sligar, and James R. Kincaid
      PNAS December 29, 2015 112 (52) 15856-15861; first published December 14, 2015. https://doi.org/10.1073/pnas.1519376113
    • Open Access
      Effects of DNA replication on mRNA noise
      Joseph R. Peterson, John A. Cole, Jingyi Fei, Taekjip Ha, and Zaida A. Luthey-Schulten
      PNAS December 29, 2015 112 (52) 15886-15891; first published December 15, 2015. https://doi.org/10.1073/pnas.1516246112
  • Earth, Atmospheric, and Planetary Sciences

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      Contact efflorescence as a pathway for crystallization of atmospherically relevant particles
      Ryan D. Davis, Sara Lance, Joshua A. Gordon, Shuichi B. Ushijima, and Margaret A. Tolbert
      PNAS December 29, 2015 112 (52) 15815-15820; first published December 14, 2015. https://doi.org/10.1073/pnas.1522860113
  • Statistics

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      Information-theoretic model comparison unifies saliency metrics
      Matthias Kümmerer, Thomas S. A. Wallis, and Matthias Bethge
      PNAS December 29, 2015 112 (52) 16054-16059; first published December 10, 2015. https://doi.org/10.1073/pnas.1510393112
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      Round-the-clock power supply and a sustainable economy via synergistic integration of solar thermal power and hydrogen processes
      Emre Gençer, Dharik S. Mallapragada, François Maréchal, Mohit Tawarmalani, and Rakesh Agrawal
      PNAS December 29, 2015 112 (52) 15821-15826; first published December 14, 2015. https://doi.org/10.1073/pnas.1513488112

Social Sciences

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    • Open Access
      Inequality, climate impacts on the future poor, and carbon prices
      Francis Dennig, Mark B. Budolfson, Marc Fleurbaey, Asher Siebert, and Robert H. Socolow
      PNAS December 29, 2015 112 (52) 15827-15832; first published December 7, 2015. https://doi.org/10.1073/pnas.1513967112
  • Psychological and Cognitive Sciences

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      Oscillatory phase shapes syllable perception
      Sanne ten Oever and Alexander T. Sack
      PNAS December 29, 2015 112 (52) 15833-15837; first published December 14, 2015. https://doi.org/10.1073/pnas.1517519112
    • Open Access
      High economic inequality leads higher-income individuals to be less generous
      • From the Cover
      Stéphane Côté, Julian House, and Robb Willer
      PNAS December 29, 2015 112 (52) 15838-15843; first published November 23, 2015. https://doi.org/10.1073/pnas.1511536112

      See companion article:

      • When the rich don't share
        - Dec 16, 2015
    • Open Access
      Neural mechanisms of social decision-making in the primate amygdala
      Steve W. C. Chang, Nicholas A. Fagan, Koji Toda, Amanda V. Utevsky, John M. Pearson, and Michael L. Platt
      PNAS December 29, 2015 112 (52) 16012-16017; first published December 14, 2015. https://doi.org/10.1073/pnas.1514761112
  • Sustainability Science

    • Open Access
      Inequality, climate impacts on the future poor, and carbon prices
      Francis Dennig, Mark B. Budolfson, Marc Fleurbaey, Asher Siebert, and Robert H. Socolow
      PNAS December 29, 2015 112 (52) 15827-15832; first published December 7, 2015. https://doi.org/10.1073/pnas.1513967112
    • You have access
      Data contradict common perceptions about a controversial provision of the US Endangered Species Act
      Jacob W. Malcom and Ya-Wei Li
      PNAS December 29, 2015 112 (52) 15844-15849; first published December 14, 2015. https://doi.org/10.1073/pnas.1516938112

      See companion article:

      • Data over anecdote
        - Mar 02, 2016

Biological Sciences

  • Applied Biological Sciences

    • You have access
      Dogs lap using acceleration-driven open pumping
      • From the Cover
      Sean Gart, John J. Socha, Pavlos P. Vlachos, and Sunghwan Jung
      PNAS December 29, 2015 112 (52) 15798-15802; first published December 14, 2015. https://doi.org/10.1073/pnas.1514842112
    • Open Access
      Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer
      Jacob L. Houghton, Brian M. Zeglis, Dalya Abdel-Atti, Robert Aggeler, Ritsuko Sawada, Brian J. Agnew, Wolfgang W. Scholz, and Jason S. Lewis
      PNAS December 29, 2015 112 (52) 15850-15855; first published December 14, 2015. https://doi.org/10.1073/pnas.1506542112
  • Biochemistry

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      Structural basis for specificity and promiscuity in a carrier protein/enzyme system from the sulfur cycle
      Daniel B. Grabarczyk, Paul E. Chappell, Steven Johnson, Lukas S. Stelzl, Susan M. Lea, and Ben C. Berks
      PNAS December 29, 2015 112 (52) E7166-E7175; first published December 11, 2015. https://doi.org/10.1073/pnas.1506386112
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      cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins
      Sudarsanareddy Lokireddy, Nikolay Vadimovich Kukushkin, and Alfred Lewis Goldberg
      PNAS December 29, 2015 112 (52) E7176-E7185; first published December 15, 2015. https://doi.org/10.1073/pnas.1522332112

      See companion article:

      • mTOR suppresses proteasomal proteolysis
        - Dec 15, 2015
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      mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy
      • Inaugural Article
      Jinghui Zhao, Bo Zhai, Steven P. Gygi, and Alfred Lewis Goldberg
      PNAS December 29, 2015 112 (52) 15790-15797; first published December 15, 2015. https://doi.org/10.1073/pnas.1521919112

      See companion article:

      • Phosphorylation of Rpn6/PSMD11 by PKA
        - Dec 15, 2015
    • You have access
      Unveiling the crucial intermediates in androgen production
      Piotr J. Mak, Michael C. Gregory, Ilia G. Denisov, Stephen G. Sligar, and James R. Kincaid
      PNAS December 29, 2015 112 (52) 15856-15861; first published December 14, 2015. https://doi.org/10.1073/pnas.1519376113
    • You have access
      Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand–receptor interactions
      • From the Cover
      Andrey V. Reshetnyak, Phillip B. Murray, Xiarong Shi, Elizabeth S. Mo, Jyotidarsini Mohanty, Francisco Tome, Hanwen Bai, Murat Gunel, Irit Lax, and Joseph Schlessinger
      PNAS December 29, 2015 112 (52) 15862-15867; first published November 16, 2015. https://doi.org/10.1073/pnas.1520099112

      See companion article:

      • Adopting ALK and LTK
        - Dec 16, 2015
    • You have access
      Target selection by natural and redesigned PUF proteins
      Douglas F. Porter, Yvonne Y. Koh, Brett VanVeller, Ronald T. Raines, and Marvin Wickens
      PNAS December 29, 2015 112 (52) 15868-15873; first published December 14, 2015. https://doi.org/10.1073/pnas.1508501112
    • You have access
      Initiation factor 2 stabilizes the ribosome in a semirotated conformation
      Clarence Ling and Dmitri N. Ermolenko
      PNAS December 29, 2015 112 (52) 15874-15879; first published December 14, 2015. https://doi.org/10.1073/pnas.1520337112
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      The terminal phycobilisome emitter, LCM: A light-harvesting pigment with a phytochrome chromophore
      Kun Tang, Wen-Long Ding, Astrid Höppner, Cheng Zhao, Lun Zhang, Yusaku Hontani, John T. M. Kennis, Wolfgang Gärtner, Hugo Scheer, Ming Zhou, and Kai-Hong Zhao
      PNAS December 29, 2015 112 (52) 15880-15885; first published December 15, 2015. https://doi.org/10.1073/pnas.1519177113
  • Biophysics and Computational Biology

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      Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle
      Keith J. Mickolajczyk, Nathan C. Deffenbaugh, Jaime Ortega Arroyo, Joanna Andrecka, Philipp Kukura, and William O. Hancock
      PNAS December 29, 2015 112 (52) E7186-E7193; first published December 16, 2015. https://doi.org/10.1073/pnas.1517638112
    • Open Access
      Effects of DNA replication on mRNA noise
      Joseph R. Peterson, John A. Cole, Jingyi Fei, Taekjip Ha, and Zaida A. Luthey-Schulten
      PNAS December 29, 2015 112 (52) 15886-15891; first published December 15, 2015. https://doi.org/10.1073/pnas.1516246112
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      Il-Hyung Lee, Hiroyuki Kai, Lars-Anders Carlson, Jay T. Groves, and James H. Hurley
      PNAS December 29, 2015 112 (52) 15892-15897; first published December 14, 2015. https://doi.org/10.1073/pnas.1518765113
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      Unexpected features of the dark proteome
      Nelson Perdigão, Julian Heinrich, Christian Stolte, Kenneth S. Sabir, Michael J. Buckley, Bruce Tabor, Beth Signal, Brian S. Gloss, Christopher J. Hammang, Burkhard Rost, Andrea Schafferhans, and Seán I. O’Donoghue
      PNAS December 29, 2015 112 (52) 15898-15903; first published November 17, 2015. https://doi.org/10.1073/pnas.1508380112
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      Bimodal rheotactic behavior reflects flagellar beat asymmetry in human sperm cells
      Anton Bukatin, Igor Kukhtevich, Norbert Stoop, Jörn Dunkel, and Vasily Kantsler
      PNAS December 29, 2015 112 (52) 15904-15909; first published December 10, 2015. https://doi.org/10.1073/pnas.1515159112
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      Detection of secondary binding sites in proteins using fragment screening
      R. Frederick Ludlow, Marcel L. Verdonk, Harpreet K. Saini, Ian J. Tickle, and Harren Jhoti
      PNAS December 29, 2015 112 (52) 15910-15915; first published December 11, 2015. https://doi.org/10.1073/pnas.1518946112
  • Cell Biology

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      Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome
      Sneha Rath, Jesse Donovan, Gena Whitney, Alisha Chitrakar, Wei Wang, and Alexei Korennykh
      PNAS December 29, 2015 112 (52) 15916-15921; first published December 14, 2015. https://doi.org/10.1073/pnas.1513034112
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  • Developmental Biology

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      Zhengui Zheng, Brooke A. Armfield, and Martin J. Cohn
      PNAS December 29, 2015 112 (52) E7194-E7203; first published November 23, 2015. https://doi.org/10.1073/pnas.1515981112

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      • Sex hormones and genital defects
        - Nov 23, 2015
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      PNAS December 29, 2015 112 (52) 15928-15933; first published December 11, 2015. https://doi.org/10.1073/pnas.1515076112
  • Ecology

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      Metabolic heat production and thermal conductance are mass-independent adaptations to thermal environment in birds and mammals
      Trevor S. Fristoe, Joseph R. Burger, Meghan A. Balk, Imran Khaliq, Christian Hof, and James H. Brown
      PNAS December 29, 2015 112 (52) 15934-15939; first published December 14, 2015. https://doi.org/10.1073/pnas.1521662112
  • Evolution

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      Emily A. Lescak, Susan L. Bassham, Julian Catchen, Ofer Gelmond, Mary L. Sherbick, Frank A. von Hippel, and William A. Cresko
      PNAS December 29, 2015 112 (52) E7204-E7212; first published December 14, 2015. https://doi.org/10.1073/pnas.1512020112
    • Open Access
      Molecular mechanisms underlying the exceptional adaptations of batoid fins
      Tetsuya Nakamura, Jeff Klomp, Joyce Pieretti, Igor Schneider, Andrew R. Gehrke, and Neil H. Shubin
      PNAS December 29, 2015 112 (52) 15940-15945; first published December 7, 2015. https://doi.org/10.1073/pnas.1521818112
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      Origin and diversification of wings: Insights from a neopteran insect
      Victor Medved, James H. Marden, Howard W. Fescemyer, Joshua P. Der, Jin Liu, Najmus Mahfooz, and Aleksandar Popadić
      PNAS December 29, 2015 112 (52) 15946-15951; first published December 14, 2015. https://doi.org/10.1073/pnas.1509517112
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      Evolution of haploid selection in predominantly diploid organisms
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      PNAS December 29, 2015 112 (52) 15952-15957; first published December 15, 2015. https://doi.org/10.1073/pnas.1512004112
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      Global divergence of the human follicle mite Demodex folliculorum: Persistent associations between host ancestry and mite lineages
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      PNAS December 29, 2015 112 (52) 15958-15963; first published December 14, 2015. https://doi.org/10.1073/pnas.1512609112
  • Genetics

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      PNAS December 29, 2015 112 (52) E7223-E7229; first published December 14, 2015. https://doi.org/10.1073/pnas.1519374113
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      HLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis
      • From the Cover
      Michael J. Ombrello, Elaine F. Remmers, Ioanna Tachmazidou, Alexei Grom, Dirk Foell, Johannes-Peter Haas, Alberto Martini, Marco Gattorno, Seza Özen, Sampath Prahalad, Andrew S. Zeft, John F. Bohnsack, Elizabeth D. Mellins, Norman T. Ilowite, Ricardo Russo, Claudio Len, Maria Odete E. Hilario, Sheila Oliveira, Rae S. M. Yeung, Alan Rosenberg, Lucy R. Wedderburn, Jordi Anton, Tobias Schwarz, Anne Hinks, Yelda Bilginer, Jane Park, Joanna Cobb, Colleen L. Satorius, Buhm Han, Elizabeth Baskin, Sara Signa, Richard H. Duerr, J. P. Achkar, M. Ilyas Kamboh, Kenneth M. Kaufman, Leah C. Kottyan, Dalila Pinto, Stephen W. Scherer, Marta E. Alarcón-Riquelme, Elisa Docampo, Xavier Estivill, Ahmet Gül, British Society of Pediatric, and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS) Group, Randomized Placebo Phase Study of Rilonacept in sJIA (RAPPORT) Investigators, Sparks-Childhood Arthritis Response to Medication Study (CHARMS) Group, Biologically Based Outcome Predictors in JIA (BBOP) Group, Paul I. W. de Bakker, Soumya Raychaudhuri, Carl D. Langefeld, Susan Thompson, Eleftheria Zeggini, Wendy Thomson, Daniel L. Kastner, Patricia Woo, and the International Childhood Arthritis Genetics (INCHARGE) Consortium
      PNAS December 29, 2015 112 (52) 15970-15975; first published November 23, 2015. https://doi.org/10.1073/pnas.1520779112

      See companion article:

      • Autoinflammation and autoimmunity in sJIA
        - Dec 17, 2015
    • You have access
      Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade
      Thomas C. Boothby, Jennifer R. Tenlen, Frank W. Smith, Jeremy R. Wang, Kiera A. Patanella, Erin Osborne Nishimura, Sophia C. Tintori, Qing Li, Corbin D. Jones, Mark Yandell, David N. Messina, Jarret Glasscock, and Bob Goldstein
      PNAS December 29, 2015 112 (52) 15976-15981; first published November 23, 2015. https://doi.org/10.1073/pnas.1510461112

      See companion article:

      • Foreign genes in H. dujardini genome assemblies
        - May 12, 2016
    • You have access
      Recombination patterns in maize reveal limits to crossover homeostasis
      Gaganpreet K. Sidhu, Celestia Fang, Mischa A. Olson, Matthieu Falque, Olivier C. Martin, and Wojciech P. Pawlowski
      PNAS December 29, 2015 112 (52) 15982-15987; first published December 14, 2015. https://doi.org/10.1073/pnas.1514265112
  • Immunology and Inflammation

    • Open Access
      Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation
      Nathalie Knies, Begüm Alankus, Andre Weilemann, Alexandar Tzankov, Kristina Brunner, Tanja Ruff, Marcus Kremer, Ulrich B. Keller, Georg Lenz, and Jürgen Ruland
      PNAS December 29, 2015 112 (52) E7230-E7238; first published December 14, 2015. https://doi.org/10.1073/pnas.1507459112
    • Open Access
      CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages
      Chunxing Zheng, Qian Yang, Chunliang Xu, Peishun Shou, Jianchang Cao, Menghui Jiang, Qing Chen, Gang Cao, Yanyan Han, Fengying Li, Wei Cao, Liying Zhang, Li Zhang, Yufang Shi, and Ying Wang
      PNAS December 29, 2015 112 (52) E7239-E7248; first published December 15, 2015. https://doi.org/10.1073/pnas.1500396113
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      Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity
      Jie Yin, Jianmei W. Leavenworth, Yang Li, Qi Luo, Huafeng Xie, Xinhua Liu, Shan Huang, Han Yan, Zheng Fu, Liyun Y. Zhang, Litao Zhang, Junwei Hao, Xudong Wu, Xianming Deng, Charles W. M. Roberts, Stuart H. Orkin, Harvey Cantor, and Xi Wang
      PNAS December 29, 2015 112 (52) 15988-15993; first published December 14, 2015. https://doi.org/10.1073/pnas.1521740112
    • Open Access
      MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice
      Limin Wu, Nainong Li, Mingfeng Zhang, Sheng-Li Xue, Kaniel Cassady, Qing Lin, Arthur D. Riggs, and Defu Zeng
      PNAS December 29, 2015 112 (52) 15994-15999; first published December 8, 2015. https://doi.org/10.1073/pnas.1521157112
    • You have access
      Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1
      Tina El Rayes, Raúl Catena, Sharrell Lee, Marcin Stawowczyk, Natasha Joshi, Claudia Fischbach, Charles A. Powell, Andrew J. Dannenberg, Nasser K. Altorki, Dingcheng Gao, and Vivek Mittal
      PNAS December 29, 2015 112 (52) 16000-16005; first published December 14, 2015. https://doi.org/10.1073/pnas.1507294112
  • Medical Sciences

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      Exogenous Hsp70 delays senescence and improves cognitive function in aging mice
      Natalia V. Bobkova, Mikhail Evgen’ev, David G. Garbuz, Alexei M. Kulikov, Alexei Morozov, Alexander Samokhin, Dmitri Velmeshev, Natalia Medvinskaya, Inna Nesterova, Andrew Pollock, and Evgeny Nudler
      PNAS December 29, 2015 112 (52) 16006-16011; first published December 14, 2015. https://doi.org/10.1073/pnas.1516131112
  • Microbiology

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      Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators
      Hal P. Bogerd, Anand V. R. Kornepati, Joy B. Marshall, Edward M. Kennedy, and Bryan R. Cullen
      PNAS December 29, 2015 112 (52) E7249-E7256; first published December 14, 2015. https://doi.org/10.1073/pnas.1516305112
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      5-hydroxymethylation of the EBV genome regulates the latent to lytic switch
      Coral K. Wille, Dhananjay M. Nawandar, Amanda N. Henning, Shidong Ma, Kayla M. Oetting, Dennis Lee, Paul Lambert, Eric C. Johannsen, and Shannon C. Kenney
      PNAS December 29, 2015 112 (52) E7257-E7265; first published December 9, 2015. https://doi.org/10.1073/pnas.1513432112
    • Open Access
      Glycan:glycan interactions: High affinity biomolecular interactions that can mediate binding of pathogenic bacteria to host cells
      Christopher J. Day, Elizabeth N. Tran, Evgeny A. Semchenko, Greg Tram, Lauren E. Hartley-Tassell, Preston S. K. Ng, Rebecca M. King, Rachel Ulanovsky, Sarah McAtamney, Michael A. Apicella, Joe Tiralongo, Renato Morona, Victoria Korolik, and Michael P. Jennings
      PNAS December 29, 2015 112 (52) E7266-E7275; first published December 16, 2015. https://doi.org/10.1073/pnas.1421082112
  • Neuroscience

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      Oscillatory phase shapes syllable perception
      Sanne ten Oever and Alexander T. Sack
      PNAS December 29, 2015 112 (52) 15833-15837; first published December 14, 2015. https://doi.org/10.1073/pnas.1517519112
    • Open Access
      Neural mechanisms of social decision-making in the primate amygdala
      Steve W. C. Chang, Nicholas A. Fagan, Koji Toda, Amanda V. Utevsky, John M. Pearson, and Michael L. Platt
      PNAS December 29, 2015 112 (52) 16012-16017; first published December 14, 2015. https://doi.org/10.1073/pnas.1514761112
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      Rapid increases in immature synapses parallel estrogen-induced hippocampal learning enhancements
      Anna Phan, Sarah Suschkov, Luke Molinaro, Kathryn Reynolds, Jennifer M. Lymer, Craig D. C. Bailey, Lee-Ming Kow, Neil J. MacLusky, Donald W. Pfaff, and Elena Choleris
      PNAS December 29, 2015 112 (52) 16018-16023; first published December 10, 2015. https://doi.org/10.1073/pnas.1522150112
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      Discontinuity of cortical gradients reflects sensory impairment
      Noam Saadon-Grosman, Zohar Tal, Eyal Itshayek, Amir Amedi, and Shahar Arzy
      PNAS December 29, 2015 112 (52) 16024-16029; first published December 11, 2015. https://doi.org/10.1073/pnas.1506214112
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      Hyperpolarization-activated, cyclic nucleotide-gated cation channels in Aplysia: Contribution to classical conditioning
      Qizong Yang, Pavlo Kuzyk, Igor Antonov, Caleb J. Bostwick, Andrea B. Kohn, Leonid L. Moroz, and Robert D. Hawkins
      PNAS December 29, 2015 112 (52) 16030-16035; first published December 14, 2015. https://doi.org/10.1073/pnas.1501731113
    • Open Access
      Frequency preference and attention effects across cortical depths in the human primary auditory cortex
      Federico De Martino, Michelle Moerel, Kamil Ugurbil, Rainer Goebel, Essa Yacoub, and Elia Formisano
      PNAS December 29, 2015 112 (52) 16036-16041; first published December 14, 2015. https://doi.org/10.1073/pnas.1507552112
  • Pharmacology

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      Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
      Sarah A. Head, Wei Shi, Liang Zhao, Kirill Gorshkov, Kalyan Pasunooti, Yue Chen, Zhiyou Deng, Ruo-jing Li, Joong Sup Shim, Wenzhi Tan, Thomas Hartung, Jin Zhang, Yingming Zhao, Marco Colombini, and Jun O. Liu
      PNAS December 29, 2015 112 (52) E7276-E7285; first published December 10, 2015. https://doi.org/10.1073/pnas.1512867112
  • Physiology

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      KCNE3 acts by promoting voltage sensor activation in KCNQ1
      Rene Barro-Soria, Marta E. Perez, and H. Peter Larsson
      PNAS December 29, 2015 112 (52) E7286-E7292; first published December 14, 2015. https://doi.org/10.1073/pnas.1516238112
    • You have access
      Musclin is an activity-stimulated myokine that enhances physical endurance
      Ekaterina Subbotina, Ana Sierra, Zhiyong Zhu, Zhan Gao, Siva Rama Krishna Koganti, Santiago Reyes, Elizabeth Stepniak, Susan A. Walsh, Michael R. Acevedo, Carmen M. Perez-Terzic, Denice M. Hodgson-Zingman, and Leonid V. Zingman
      PNAS December 29, 2015 112 (52) 16042-16047; first published December 14, 2015. https://doi.org/10.1073/pnas.1514250112
  • Plant Biology

    • Open Access
      Methylome analysis reveals an important role for epigenetic changes in the regulation of the Arabidopsis response to phosphate starvation
      Lenin Yong-Villalobos, Sandra Isabel González-Morales, Kazimierz Wrobel, Dolores Gutiérrez-Alanis, Sergio Alan Cervantes-Peréz, Corina Hayano-Kanashiro, Araceli Oropeza-Aburto, Alfredo Cruz-Ramírez, Octavio Martínez, and Luis Herrera-Estrella
      PNAS December 29, 2015 112 (52) E7293-E7302; first published December 14, 2015. https://doi.org/10.1073/pnas.1522301112
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      Identification of MEDIATOR16 as the Arabidopsis COBRA suppressor MONGOOSE1
      Nadav Sorek, Heidi Szemenyei, Hagit Sorek, Abigail Landers, Heather Knight, Stefan Bauer, David E. Wemmer, and Chris R. Somerville
      PNAS December 29, 2015 112 (52) 16048-16053; first published December 11, 2015. https://doi.org/10.1073/pnas.1521675112
  • Psychological and Cognitive Sciences

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      Information-theoretic model comparison unifies saliency metrics
      Matthias Kümmerer, Thomas S. A. Wallis, and Matthias Bethge
      PNAS December 29, 2015 112 (52) 16054-16059; first published December 10, 2015. https://doi.org/10.1073/pnas.1510393112
  • Sustainability Science

    • You have access
      Data contradict common perceptions about a controversial provision of the US Endangered Species Act
      Jacob W. Malcom and Ya-Wei Li
      PNAS December 29, 2015 112 (52) 15844-15849; first published December 14, 2015. https://doi.org/10.1073/pnas.1516938112

      See companion article:

      • Data over anecdote
        - Mar 02, 2016

Corrections (Online Only)

  • You have access
    Correction for Mertens et al., Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity
    PNAS December 29, 2015 112 (52) E7303; first published December 22, 2015. https://doi.org/10.1073/pnas.1522662112
  • You have access
    Correction for Suzuki et al., Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling
    PNAS December 29, 2015 112 (52) E7304-E7305; first published December 22, 2015. https://doi.org/10.1073/pnas.1522665112
  • You have access
    Correction for Gupta et al., RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA
    PNAS December 29, 2015 112 (52) E7306; first published December 23, 2015. https://doi.org/10.1073/pnas.1523895113
  • You have access
    Correction for Mitra et al., Lag threads organize the brain’s intrinsic activity
    PNAS December 29, 2015 112 (52) E7307; first published December 22, 2015. https://doi.org/10.1073/pnas.1523893113
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Proceedings of the National Academy of Sciences: 112 (52)
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