Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology
Research Article

Massively expedited genome-wide heritability analysis (MEGHA)

Tian Ge, Thomas E. Nichols, Phil H. Lee, Avram J. Holmes, Joshua L. Roffman, Randy L. Buckner, Mert R. Sabuncu, and Jordan W. Smoller
PNAS February 24, 2015 112 (8) 2479-2484; first published February 9, 2015; https://doi.org/10.1073/pnas.1415603112
Tian Ge
aAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129;
bPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114;
cStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tge1@mgh.harvard.edu jsmoller@hms.harvard.edu
Thomas E. Nichols
dDepartment of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry CV4 7AL, United Kingdom;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Phil H. Lee
bPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114;
cStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Avram J. Holmes
eDepartment of Psychology, Yale University, New Haven, CT 06520;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joshua L. Roffman
fDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Randy L. Buckner
aAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129;
fDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114;
gDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138; and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mert R. Sabuncu
aAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129;
hComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jordan W. Smoller
bPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114;
cStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tge1@mgh.harvard.edu jsmoller@hms.harvard.edu
  1. Edited by C. Thomas Caskey, Baylor College of Medicine, Houston, TX, and approved January 15, 2015 (received for review August 12, 2014)

  • Article
  • Figures & SI
  • Info & Metrics
  • PDF
Loading

Online Impact

 

Article Information

vol. 112 no. 8 2479-2484
DOI: 
https://doi.org/10.1073/pnas.1415603112
PubMed: 
25675487

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue February 24, 2015.
  • Published first February 9, 2015.

Copyright & Usage: 
Freely available online through the PNAS open access option.

Author Information

  1. Tian Gea,b,c,1,
  2. Thomas E. Nicholsd,
  3. Phil H. Leeb,c,
  4. Avram J. Holmese,
  5. Joshua L. Roffmanf,
  6. Randy L. Bucknera,f,g,
  7. Mert R. Sabuncua,h,2, and
  8. Jordan W. Smollerb,c,1,2
  1. aAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129;
  2. bPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114;
  3. cStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02138;
  4. dDepartment of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry CV4 7AL, United Kingdom;
  5. eDepartment of Psychology, Yale University, New Haven, CT 06520;
  6. fDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114;
  7. gDepartment of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138; and
  8. hComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139
  1. Edited by C. Thomas Caskey, Baylor College of Medicine, Houston, TX, and approved January 15, 2015 (received for review August 12, 2014)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: tge1{at}mgh.harvard.edu or jsmoller{at}hms.harvard.edu.
  • ↵2M.R.S. and J.W.S. contributed equally to this work.

  • Author contributions: T.G., J.L.R., R.L.B., M.R.S., and J.W.S. designed research; T.G., P.H.L., A.J.H., J.L.R., R.L.B., M.R.S., and J.W.S. performed research; T.G. and T.E.N. contributed new reagents/analytic tools; T.G., P.H.L., and A.J.H. analyzed data; and T.G., R.L.B., M.R.S., and J.W.S. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1415603112/-/DCSupplemental.

Cited By...

  • 40 Citations
  • 39 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders
    Jordan W Smoller
    Neuropsychopharmacology 2016 41 1
  • Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
    Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee, Francis J McMahon, Andreas Meyer-Lindenberg, Manuel Mattheisen, Ole A Andreassen, Oliver Gruber, Perminder S Sachdev, Roberto Roiz-Santiañez, Andrew J Saykin, Stefan Ehrlich, Karen A Mather, Jessica A Turner, Emanuel Schwarz, Anbupalam Thalamuthu, Yin Yao, Yvonne Y W Ho, Nicholas G Martin, Margaret J Wright, Michael C O'Donovan, Paul M Thompson, Benjamin M Neale, Sarah E Medland, Patrick F Sullivan
    Nature Neuroscience 2016 19 3
  • ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide
    Paul M. Thompson, Ole A. Andreassen, Alejandro Arias-Vasquez, Carrie E. Bearden, Premika S. Boedhoe, Rachel M. Brouwer, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Dara M. Cannon, Ronald A. Cohen, Patricia J. Conrod, Anders M. Dale, Ian J. Deary, Emily L. Dennis, Marcel A. de Reus, Sylvane Desrivieres, Danai Dima, Gary Donohoe, Simon E. Fisher, Jean-Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Habib Ganjgahi, Hugh Garavan, David C. Glahn, Hans J. Grabe, Tulio Guadalupe, Boris A. Gutman, Ryota Hashimoto, Derrek P. Hibar, Dominic Holland, Martine Hoogman, Hilleke E. Hulshoff Pol, Norbert Hosten, Neda Jahanshad, Sinead Kelly, Peter Kochunov, William S. Kremen, Phil H. Lee, Scott Mackey, Nicholas G. Martin, Bernard Mazoyer, Colm McDonald, Sarah E. Medland, Rajendra A. Morey, Thomas E. Nichols, Tomas Paus, Zdenka Pausova, Lianne Schmaal, Gunter Schumann, Li Shen, Sanjay M. Sisodiya, Dirk J.A. Smit, Jordan W. Smoller, Dan J. Stein, Jason L. Stein, Roberto Toro, Jessica A. Turner, Martijn P. van den Heuvel, Odile L. van den Heuvel, Theo G.M. van Erp, Daan van Rooij, Dick J. Veltman, Henrik Walter, Yalin Wang, Joanna M. Wardlaw, Christopher D. Whelan, Margaret J. Wright, Jieping Ye
    NeuroImage 2017 145
  • Phenome-wide heritability analysis of the UK Biobank
    Tian Ge, Chia-Yen Chen, Benjamin M. Neale, Mert R. Sabuncu, Jordan W. Smoller, Benjamin W. Domingue
    PLOS Genetics 2017 13 4
  • Polygenic Epidemiology
    Frank Dudbridge
    Genetic Epidemiology 2016 40 4
  • Connectome Disconnectivity and Cortical Gene Expression in Patients With Schizophrenia
    Ingrid A.C. Romme, Marcel A. de Reus, Roel A. Ophoff, René S. Kahn, Martijn P. van den Heuvel
    Biological Psychiatry 2017 81 6
  • Heritability analysis with repeat measurements and its application to resting-state functional connectivity
    Tian Ge, Avram J. Holmes, Randy L. Buckner, Jordan W. Smoller, Mert R. Sabuncu
    Proceedings of the National Academy of Sciences 2017 114 21
  • Sample composition alters associations between age and brain structure
    Kaja Z. LeWinn, Margaret A. Sheridan, Katherine M. Keyes, Ava Hamilton, Katie A. McLaughlin
    Nature Communications 2017 8 1
  • Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
    P H Lee, J T Baker, A J Holmes, N Jahanshad, T Ge, J-Y Jung, Y Cruz, D S Manoach, D P Hibar, J Faskowitz, K L McMahon, G I de Zubicaray, N H Martin, M J Wright, D Öngür, R Buckner, J Roffman, P M Thompson, J W Smoller
    Molecular Psychiatry 2016 21 12
  • Heritability of the shape of subcortical brain structures in the general population
    Gennady V. Roshchupkin, Boris A. Gutman, Meike W. Vernooij, Neda Jahanshad, Nicholas G. Martin, Albert Hofman, Katie L. McMahon, Sven J. van der Lee, Cornelia M. van Duijn, Greig I. de Zubicaray, André G. Uitterlinden, Margaret J. Wright, Wiro J. Niessen, Paul M. Thompson, M. Arfan Ikram, Hieab H. H. Adams
    Nature Communications 2016 7 1
  • Morphometricity as a measure of the neuroanatomical signature of a trait
    Mert R. Sabuncu, Tian Ge, Avram J. Holmes, Jordan W. Smoller, Randy L. Buckner, Bruce Fischl
    Proceedings of the National Academy of Sciences 2016 113 39
  • Endophenotype best practices
    William G. Iacono, Stephen M. Malone, Scott I. Vrieze
    International Journal of Psychophysiology 2017 111
  • Multidimensional heritability analysis of neuroanatomical shape
    Tian Ge, Martin Reuter, Anderson M. Winkler, Avram J. Holmes, Phil H. Lee, Lee S. Tirrell, Joshua L. Roffman, Randy L. Buckner, Jordan W. Smoller, Mert R. Sabuncu
    Nature Communications 2016 7 1
  • The use of electronic health records for psychiatric phenotyping and genomics
    Jordan W. Smoller
    American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2018 177 7
  • A peripheral epigenetic signature of immune system genes is linked to neocortical thickness and memory
    Virginie Freytag, Tania Carrillo-Roa, Annette Milnik, Philipp G. Sämann, Vanja Vukojevic, David Coynel, Philippe Demougin, Tobias Egli, Leo Gschwind, Frank Jessen, Eva Loos, Wolfgang Maier, Steffi G. Riedel-Heller, Martin Scherer, Christian Vogler, Michael Wagner, Elisabeth B. Binder, Dominique J. -F. de Quervain, Andreas Papassotiropoulos
    Nature Communications 2017 8 1
  • Do regional brain volumes and major depressive disorder share genetic architecture? A study of Generation Scotland (n=19 762), UK Biobank (n=24 048) and the English Longitudinal Study of Ageing (n=5766)
    E M Wigmore, T-K Clarke, D M Howard, M J Adams, L S Hall, Y Zeng, J Gibson, G Davies, A M Fernandez-Pujals, P A Thomson, C Hayward, B H Smith, L J Hocking, S Padmanabhan, I J Deary, D J Porteous, K K Nicodemus, A M McIntosh
    Translational Psychiatry 2017 7 8
  • The Genetics of Endophenotypes of Neurofunction to Understand Schizophrenia (GENUS) consortium: A collaborative cognitive and neuroimaging genetics project
    Gabriëlla A.M. Blokland, Elisabetta C. del Re, Raquelle I. Mesholam-Gately, Jorge Jovicich, Joey W. Trampush, Matcheri S. Keshavan, Lynn E. DeLisi, James T.R. Walters, Jessica A. Turner, Anil K. Malhotra, Todd Lencz, Martha E. Shenton, Aristotle N. Voineskos, Dan Rujescu, Ina Giegling, René S. Kahn, Joshua L. Roffman, Daphne J. Holt, Stefan Ehrlich, Zora Kikinis, Paola Dazzan, Robin M. Murray, Marta Di Forti, Jimmy Lee, Kang Sim, Max Lam, Rick P.F. Wolthusen, Sonja M.C. de Zwarte, Esther Walton, Donna Cosgrove, Sinead Kelly, Nasim Maleki, Lisa Osiecki, Marco M. Picchioni, Elvira Bramon, Manuela Russo, Anthony S. David, Valeria Mondelli, Antje A.T.S. Reinders, M. Aurora Falcone, Annette M. Hartmann, Bettina Konte, Derek W. Morris, Michael Gill, Aiden P. Corvin, Wiepke Cahn, New Fei Ho, Jian Jun Liu, Richard S.E. Keefe, Randy L. Gollub, Dara S. Manoach, Vince D. Calhoun, S. Charles Schulz, Scott R. Sponheim, Donald C. Goff, Stephen L. Buka, Sara Cherkerzian, Heidi W. Thermenos, Marek Kubicki, Paul G. Nestor, Erin W. Dickie, Evangelos Vassos, Simone Ciufolini, Tiago Reis Marques, Nicolas A. Crossley, Shaun M. Purcell, Jordan W. Smoller, Neeltje E.M. van Haren, Timothea Toulopoulou, Gary Donohoe, Jill M. Goldstein, Larry J. Seidman, Robert W. McCarley, Tracey L. Petryshen
    Schizophrenia Research 2018 195
  • Beyond heritability: improving discoverability in imaging genetics
    Chun Chieh Fan, Olav B Smeland, Andrew J Schork, Chi-Hua Chen, Dominic Holland, Min-Tzu Lo, V S Sundar, Oleksandr Frei, Terry L Jernigan, Ole A Andreassen, Anders M Dale
    Human Molecular Genetics 2018 27 R1
  • Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome
    Mei‐Lyn Ong, Ta A. Tuan, Joann Poh, Ai L. Teh, Li Chen, Hong Pan, Julia L. MacIsaac, Michael S. Kobor, Yap S. Chong, Kenneth Kwek, Seang M. Saw, Keith M. Godfrey, Peter D. Gluckman, Marielle V. Fortier, Neerja Karnani, Michael J. Meaney, Anqi Qiu, Joanna D. Holbrook
    Genes, Brain and Behavior 2019 18 7
  • Neuroimaging Genetic Risk for Alzheimer’s Disease in Preclinical Individuals: From Candidate Genes to Polygenic Approaches
    Theresa M. Harrison, Susan Y. Bookheimer
    Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2016 1 1
  • The Shared Genetic Basis of Educational Attainment and Cerebral Cortical Morphology
    Tian Ge, Chia-Yen Chen, Alysa E Doyle, Richard Vettermann, Lauri J Tuominen, Daphne J Holt, Mert R Sabuncu, Jordan W Smoller
    Cerebral Cortex 2019 29 8
  • Genome-Wide Estimates of Heritability for Social Demographic Outcomes
    Benjamin W. Domingue, Robbee Wedow, Dalton Conley, Matt McQueen, Thomas J. Hoffmann, Jason D. Boardman
    Biodemography and Social Biology 2016 62 1
  • Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies
    Bingxin Zhao, Joseph G Ibrahim, Yun Li, Tengfei Li, Yue Wang, Yue Shan, Ziliang Zhu, Fan Zhou, Jingwen Zhang, Chao Huang, Huiling Liao, Liuqing Yang, Paul M Thompson, Hongtu Zhu
    Cerebral Cortex 2019 29 7
  • Recent developments in the genetics of attention-deficit hyperactivity disorder
    Oliver Grimm, Sarah Kittel-Schneider, Andreas Reif
    Psychiatry and Clinical Neurosciences 2018 72 9
  • Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
    Regev Schweiger, Eyal Fisher, Omer Weissbrod, Elior Rahmani, Martina Müller-Nurasyid, Sonja Kunze, Christian Gieger, Melanie Waldenberger, Saharon Rosset, Eran Halperin
    Nature Communications 2018 9 1
  • Imaging local genetic influences on cortical folding
    Aaron F. Alexander-Bloch, Armin Raznahan, Simon N. Vandekar, Jakob Seidlitz, Zhixin Lu, Samuel R. Mathias, Emma Knowles, Josephine Mollon, Amanda Rodrigue, Joanne E. Curran, Harald H. H. Görring, Theodore D. Satterthwaite, Raquel E. Gur, Danielle S. Bassett, Gil D. Hoftman, Godfrey Pearlson, Russell T. Shinohara, Siyuan Liu, Peter T. Fox, Laura Almasy, John Blangero, David C. Glahn
    Proceedings of the National Academy of Sciences 2020 117 13
  • Nonlinear association criterion, nonlinear Granger causality and related issues with applications to neuroimage studies
    Chenyang Tao, Jianfeng Feng
    Journal of Neuroscience Methods 2016 262
  • Another Round of “Clue” to Uncover the Mystery of Complex Traits
    Shefali Verma, Marylyn Ritchie
    Genes 2018 9 2
  • Generalized reduced rank latent factor regression for high dimensional tensor fields, and neuroimaging-genetic applications
    Chenyang Tao, Thomas E. Nichols, Xue Hua, Christopher R.K. Ching, Edmund T. Rolls, Paul M. Thompson, Jianfeng Feng
    NeuroImage 2017 144
  • RL-SKAT: An Exact and Efficient Score Test for Heritability and Set Tests
    Regev Schweiger, Omer Weissbrod, Elior Rahmani, Martina Müller-Nurasyid, Sonja Kunze, Christian Gieger, Melanie Waldenberger, Saharon Rosset, Eran Halperin
    Genetics 2017 207 4
  • Accelerated estimation and permutation inference for ACE modeling
    Xu Chen, Elia Formisano, Gabriëlla A. M. Blokland, Lachlan T. Strike, Katie L. McMahon, Greig I. Zubicaray, Paul M. Thompson, Margaret J. Wright, Anderson M. Winkler, Tian Ge, Thomas E. Nichols
    Human Brain Mapping 2019
  • Machine Learning and Medical Imaging
    T. Ge, J.W. Smoller, M.R. Sabuncu
    2016
  • Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes
    Yize Zhao, Tengfei Li, Hongtu Zhu
    Biostatistics 2020
  • Cognitive specialization for verbal vs. spatial ability in men and women: Neural and behavioral correlates
    Ronald A. Yeo, Sephira G. Ryman, Melissa E. Thompson, Martijn P. van den Heuvel, Marcel A. de Reus, Jessica Pommy, Brandi Seaman, Rex E. Jung
    Personality and Individual Differences 2016 102
  • Human Population Genetics and Genomics
    Alan R. Templeton
    2019
  • Imaging Genetics
    Adrian V. Dalca, Nematollah K. Batmanghelich, Mert R. Sabuncu, Li Shen
    2018
  • Polygenic Architecture of Human Neuroanatomical Diversity
    Anne Biton, Nicolas Traut, Jean-Baptiste Poline, Benjamin S Aribisala, Mark E Bastin, Robin Bülow, Simon R Cox, Ian J Deary, Masaki Fukunaga, Hans J Grabe, Saskia Hagenaars, Ryota Hashimoto, Masataka Kikuchi, Susana Muñoz Maniega, Matthias Nauck, Natalie A Royle, Alexander Teumer, Maria Valdés Hernández, Uwe Völker, Joanna M Wardlaw, Katharina Wittfeld, Hidenaga Yamamori, Thomas Bourgeron, Roberto Toro
    Cerebral Cortex 2020 30 4
  • Reliable heritability estimation using sparse regularization in ultrahigh dimensional genome-wide association studies
    Xin Li, Dongya Wu, Yue Cui, Bing Liu, Henrik Walter, Gunter Schumann, Chong Li, Tianzi Jiang
    BMC Bioinformatics 2019 20 1
  • Unpaired data empowers association tests
    Mingming Gong, Peng Liu, Frank C Sciurba, Petar Stojanov, Dacheng Tao, George C Tseng, Kun Zhang, Kayhan Batmanghelich, Valencia Alfonso
    Bioinformatics 2020

Article usage

Article usage: February 2015 to January 2021

AbstractFullPdf
Feb 20156989183625
Mar 20152969308281
Apr 201592975112
May 201583973115
Jun 20155226798
Jul 20151828647
Aug 20151535033
Sep 20151043145
Oct 2015893232
Nov 2015964246
Dec 20151103853
Total 2015129829851487
Jan 20161113225
Feb 2016973445
Mar 2016814241
Apr 2016851637
May 2016822725
Jun 2016612822
Jul 2016932931
Aug 2016821743
Sep 20161081953
Oct 2016572446
Nov 2016491526
Dec 2016693026
Total 2016975313420
Jan 2017472121
Feb 2017471913
Mar 2017722427
Apr 2017481019
May 2017503530
Jun 2017362826
Jul 2017461920
Aug 2017423135
Sep 2017371413
Oct 2017472510
Nov 2017431121
Dec 201729911
Total 2017544246246
Jan 2018373315
Feb 2018292711
Mar 2018617416
Apr 2018404312
May 2018666427
Jun 2018475517
Jul 201832346
Aug 2018313111
Sep 2018424513
Oct 20184538
Nov 20185399
Dec 201818397
Total 2018412537152
Jan 2019113911
Feb 20195399
Mar 2019129116
Apr 201985611
May 2019165225
Jun 201963215
Jul 201973817
Aug 201972119
Sep 201922112
Oct 2019113726
Nov 201922813
Dec 201982712
Total 201995481186
Jan 20206275
Feb 202012910
Mar 202032213
Apr 202091811
May 20206279
Jun 202031926
Jul 202042224
Aug 20204198
Sep 202083414
Oct 202042416
Nov 2020103217
Dec 2020173122
Total 202075304175
Jan 202132610
Total 202132610
Total1508628922676
PreviousNext
Back to top
Article Alerts
Email Article

Thank you for your interest in spreading the word on PNAS.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Massively expedited genome-wide heritability analysis (MEGHA)
(Your Name) has sent you a message from PNAS
(Your Name) thought you would like to see the PNAS web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Massively expedited heritability analysis
Tian Ge, Thomas E. Nichols, Phil H. Lee, Avram J. Holmes, Joshua L. Roffman, Randy L. Buckner, Mert R. Sabuncu, Jordan W. Smoller
Proceedings of the National Academy of Sciences Feb 2015, 112 (8) 2479-2484; DOI: 10.1073/pnas.1415603112

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Massively expedited heritability analysis
Tian Ge, Thomas E. Nichols, Phil H. Lee, Avram J. Holmes, Joshua L. Roffman, Randy L. Buckner, Mert R. Sabuncu, Jordan W. Smoller
Proceedings of the National Academy of Sciences Feb 2015, 112 (8) 2479-2484; DOI: 10.1073/pnas.1415603112
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Mendeley logo Mendeley
Proceedings of the National Academy of Sciences: 112 (8)
Table of Contents

Submit

Sign up for Article Alerts

Article Classifications

  • Biological Sciences
  • Genetics
  • Physical Sciences
  • Statistics

Jump to section

  • Article
    • Abstract
    • Results
    • Discussion
    • Materials and Methods
    • Acknowledgments
    • Footnotes
    • References
  • Figures & SI
  • Info & Metrics
  • PDF

You May Also be Interested in

Abstract depiction of a guitar and musical note
Science & Culture: At the nexus of music and medicine, some see disease treatments
Although the evidence is still limited, a growing body of research suggests music may have beneficial effects for diseases such as Parkinson’s.
Image credit: Shutterstock/agsandrew.
Scientist looking at an electronic tablet
Opinion: Standardizing gene product nomenclature—a call to action
Biomedical communities and journals need to standardize nomenclature of gene products to enhance accuracy in scientific and public communication.
Image credit: Shutterstock/greenbutterfly.
One red and one yellow modeled protein structures
Journal Club: Study reveals evolutionary origins of fold-switching protein
Shapeshifting designs could have wide-ranging pharmaceutical and biomedical applications in coming years.
Image credit: Acacia Dishman/Medical College of Wisconsin.
White and blue bird
Hazards of ozone pollution to birds
Amanda Rodewald, Ivan Rudik, and Catherine Kling talk about the hazards of ozone pollution to birds.
Listen
Past PodcastsSubscribe
Goats standing in a pin
Transplantation of sperm-producing stem cells
CRISPR-Cas9 gene editing can improve the effectiveness of spermatogonial stem cell transplantation in mice and livestock, a study finds.
Image credit: Jon M. Oatley.

Similar Articles

Site Logo
Powered by HighWire
  • Submit Manuscript
  • Twitter
  • Facebook
  • RSS Feeds
  • Email Alerts

Articles

  • Current Issue
  • Latest Articles
  • Archive

PNAS Portals

  • Anthropology
  • Chemistry
  • Classics
  • Front Matter
  • Physics
  • Sustainability Science
  • Teaching Resources

Information

  • Authors
  • Editorial Board
  • Reviewers
  • Librarians
  • Press
  • Site Map
  • PNAS Updates

Feedback    Privacy/Legal

Copyright © 2021 National Academy of Sciences. Online ISSN 1091-6490