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Research Article

Stokes trap for multiplexed particle manipulation and assembly using fluidics

Anish Shenoy, Christopher V. Rao, and Charles M. Schroeder
  1. aDepartment of Mechanical Science and Engineering, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
  2. bDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
  3. cCenter for Biophysics and Computational Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801

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PNAS April 12, 2016 113 (15) 3976-3981; first published March 28, 2016; https://doi.org/10.1073/pnas.1525162113
Anish Shenoy
aDepartment of Mechanical Science and Engineering, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
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Christopher V. Rao
bDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
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Charles M. Schroeder
bDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana–Champaign, Urbana, IL 61801;
cCenter for Biophysics and Computational Biology, University of Illinois at Urbana–Champaign, Urbana, IL 61801
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  • For correspondence: cms@illinois.edu
  1. Edited by David A. Weitz, Harvard University, Cambridge, MA, and approved March 1, 2016 (received for review December 20, 2015)

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Significance

In recent years, techniques for trapping and manipulating small particles and single molecules have catalyzed major advances in several fields of science. Here, we describe a new method for confining, manipulating, and assembling multiple particles in free solution using the sole action of fluid flow. The Stokes trap provides a fundamentally new method for particle manipulation and assembly using a simple microfluidic device and nonlinear feedback control in the absence of optical, electric, or magnetic fields. This method holds strong potential to enable fundamental studies in soft materials, colloidal science, and biophysics.

Abstract

The ability to confine and manipulate single particles and molecules has revolutionized several fields of science. Hydrodynamic trapping offers an attractive method for particle manipulation in free solution without the need for optical, electric, acoustic, or magnetic fields. Here, we develop and demonstrate the Stokes trap, which is a new method for trapping multiple particles using only fluid flow. We demonstrate simultaneous manipulation of two particles in a simple microfluidic device using model predictive control. We further show that this approach can be used for fluidic-directed assembly of multiple particles in solution. Overall, this technique opens new vistas for fundamental studies of particle–particle interactions and provides a new method for the directed assembly of colloidal particles.

  • microfluidics
  • trapping
  • directed assembly
  • Stokes
  • hydrodynamic

Footnotes

  • ↵1To whom correspondence should be addressed. Email: cms{at}illinois.edu.
  • Author contributions: A.S. and C.M.S. designed research; A.S. performed research; C.V.R. contributed new reagents/analytic tools; A.S. analyzed data; and A.S., C.V.R., and C.M.S. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1525162113/-/DCSupplemental.

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Stokes trap for multiplexed particle manipulation
Anish Shenoy, Christopher V. Rao, Charles M. Schroeder
Proceedings of the National Academy of Sciences Apr 2016, 113 (15) 3976-3981; DOI: 10.1073/pnas.1525162113

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Stokes trap for multiplexed particle manipulation
Anish Shenoy, Christopher V. Rao, Charles M. Schroeder
Proceedings of the National Academy of Sciences Apr 2016, 113 (15) 3976-3981; DOI: 10.1073/pnas.1525162113
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Proceedings of the National Academy of Sciences: 113 (15)
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    • Modeling and Design of the Stokes Trap
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