Proceedings of the National Academy of Sciences: 113 (16)

New Research In

April 19, 2016; vol. 113 no. 16

This Week in PNAS

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In This Issue
PNAS April 19, 2016 113 (16) 4231-4233; https://doi.org/10.1073/iti1616113

Letters (Online Only)

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Anthropogenic aerosols are a potential cause for migration of the summer monsoon rain belt in China
Shaocai Yu, Pengfei Li, Liqiang Wang, Peng Wang, Si Wang, Shucheng Chang, Weiping Liu, and Kiran Alapaty

PNAS April 19, 2016 113 (16) E2209-E2210; first published March 22, 2016. https://doi.org/10.1073/pnas.1601104113
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Reply to Yu et al.: Global temperature change as the ultimate driver of the shift in the summer monsoon rain belt in East Asia
Shiling Yang, Zhongli Ding, Yangyang Li, Xu Wang, Wenying Jiang, and Xiaofang Huang

PNAS April 19, 2016 113 (16) E2211-E2212; first published March 22, 2016. https://doi.org/10.1073/pnas.1601768113
See companion article:
Warming-induced northwestward migration of the East Asian monsoon rain belt from the Last Glacial Maximum to the mid-Holocene
- Oct 27, 2015
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Reply to Stoet and Geary: Effects of gendered behavior on testosterone, not sex differences, as research focus
Sari M. van Anders, Katherine L. Goldey, and Jeffrey Steiger

PNAS April 19, 2016 113 (16) E2213-E2214; first published March 29, 2016. https://doi.org/10.1073/pnas.1522837113
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Effects of gendered behavior on testosterone in women and men
- Nov 10, 2015
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Emergence of sociocultural norms restricting intermarriage in large social strata (endogamy) coincides with foreign invasions of India
Murali K. Vadivelu

PNAS April 19, 2016 113 (16) E2215-E2217; first published April 8, 2016. https://doi.org/10.1073/pnas.1602697113

Science and Culture

How science intersects with culture.

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Science and Culture: Terraforming a volcano, artfully
Front Matter
Amber Dance

PNAS April 19, 2016 113 (16) 4234-4235; https://doi.org/10.1073/pnas.1603563113

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: A big role for a microbial parasite
Front Matter
Karen Hopkin

PNAS April 19, 2016 113 (16) 4236-4237; https://doi.org/10.1073/pnas.1603933113

Commentaries

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Inference on graphs via semidefinite programming
Afonso S. Bandeira

PNAS April 19, 2016 113 (16) 4238-4239; first published April 8, 2016. https://doi.org/10.1073/pnas.1603405113
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Phase transitions in semidefinite relaxations
- Apr 19, 2016
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HERV-K HML-2 diversity among humans
Jack Lenz

PNAS April 19, 2016 113 (16) 4240-4242; first published April 8, 2016. https://doi.org/10.1073/pnas.1603569113
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Discovery of unfixed endogenous retrovirus insertions in diverse human populations
- Apr 19, 2016
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Convergence on climate warming by black carbon aerosols
Örjan Gustafsson and Veerabhadran Ramanathan

PNAS April 19, 2016 113 (16) 4243-4245; first published April 11, 2016. https://doi.org/10.1073/pnas.1603570113
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Markedly enhanced absorption and direct radiative forcing of black carbon under polluted urban environments
- Apr 19, 2016
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Elusive marine nitrogen fixation
Nicolas Gruber

PNAS April 19, 2016 113 (16) 4246-4248; first published April 8, 2016. https://doi.org/10.1073/pnas.1603646113
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Low rates of nitrogen fixation in eastern tropical South Pacific surface waters
- Apr 19, 2016

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS April 19, 2016 113 (16) 4249-4251; https://doi.org/10.1073/pnas.ss11316

Physical Sciences

Applied Mathematics
- Open Access
  Phase transitions in semidefinite relaxations
  From the Cover
  
  Adel Javanmard, Andrea Montanari, and Federico Ricci-Tersenghi
  
  PNAS April 19, 2016 113 (16) E2218-E2223; first published March 21, 2016. https://doi.org/10.1073/pnas.1523097113
  
  See companion article:
  Inference on graphs via semidefinite programming
  - Apr 19, 2016
Chemistry
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  Necessity of capillary modes in a minimal model of nanoscale hydrophobic solvation
  Suriyanarayanan Vaikuntanathan, Grant Rotskoff, Alexander Hudson, and Phillip L. Geissler
  
  PNAS April 19, 2016 113 (16) E2224-E2230; first published March 8, 2016. https://doi.org/10.1073/pnas.1513659113
  
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  The hydrophobic effect, and fluctuations: The long and the short of it
  - Apr 26, 2016
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  Cellular uptake and anticancer activity of carboxylated gallium corroles
  Melanie Pribisko, Joshua Palmer, Robert H. Grubbs, Harry B. Gray, John Termini, and Punnajit Lim
  
  PNAS April 19, 2016 113 (16) E2258-E2266; first published April 4, 2016. https://doi.org/10.1073/pnas.1517402113
- Open Access
  How to explain microemulsions formed by solvent mixtures without conventional surfactants
  Thomas N. Zemb, Michael Klossek, Tobias Lopian, Julien Marcus, Sebastian Schöettl, Dominik Horinek, Sylvain F. Prevost, Didier Touraud, Olivier Diat, Stjepan Marčelja, and Werner Kunz
  
  PNAS April 19, 2016 113 (16) 4260-4265; first published April 1, 2016. https://doi.org/10.1073/pnas.1515708113
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Markedly enhanced absorption and direct radiative forcing of black carbon under polluted urban environments
  From the Cover
  
  Jianfei Peng, Min Hu, Song Guo, Zhuofei Du, Jing Zheng, Dongjie Shang, Misti Levy Zamora, Limin Zeng, Min Shao, Yu-Sheng Wu, Jun Zheng, Yuan Wang, Crystal R. Glen, Donald R. Collins, Mario J. Molina, and Renyi Zhang
  
  PNAS April 19, 2016 113 (16) 4266-4271; first published March 28, 2016. https://doi.org/10.1073/pnas.1602310113
  
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  Convergence on climate warming by black carbon aerosols
  - Apr 19, 2016
  
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  Reply to Boucher et al.: Rate and timescale of black carbon aging regulate direct radiative forcing
  - Aug 30, 2016
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  Accumulation of formamide in hydrothermal pores to form prebiotic nucleobases
  Doreen Niether, Dzmitry Afanasenkau, Jan K. G. Dhont, and Simone Wiegand
  
  PNAS April 19, 2016 113 (16) 4272-4277; first published April 4, 2016. https://doi.org/10.1073/pnas.1600275113
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  Importance of ocean salinity for climate and habitability
  Jodie Cullum, David P. Stevens, and Manoj M. Joshi
  
  PNAS April 19, 2016 113 (16) 4278-4283; first published April 4, 2016. https://doi.org/10.1073/pnas.1522034113
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  Tiny individuals attached to a new Silurian arthropod suggest a unique mode of brood care
  Derek E. G. Briggs, Derek J. Siveter, David J. Siveter, Mark D. Sutton, and David Legg
  
  PNAS April 19, 2016 113 (16) 4410-4415; first published April 4, 2016. https://doi.org/10.1073/pnas.1600489113
  
  See companion article:
  Reply to Piper: Aquilonifer’s kites are not mites
  - Jun 14, 2016
Engineering
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  Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction
  Danny Bavli, Sebastian Prill, Elishai Ezra, Gahl Levy, Merav Cohen, Mathieu Vinken, Jan Vanfleteren, Magnus Jaeger, and Yaakov Nahmias
  
  PNAS April 19, 2016 113 (16) E2231-E2240; first published April 4, 2016. https://doi.org/10.1073/pnas.1522556113
Environmental Sciences
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  Photodegradation alleviates the lignin bottleneck for carbon turnover in terrestrial ecosystems
  Amy T. Austin, M. Soledad Méndez, and Carlos L. Ballaré
  
  PNAS April 19, 2016 113 (16) 4392-4397; first published April 4, 2016. https://doi.org/10.1073/pnas.1516157113
Physics
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  Hall effect in quantum critical charge-cluster glass
  Jie Wu, Anthony T. Bollinger, Yujie Sun, and Ivan Božović
  
  PNAS April 19, 2016 113 (16) 4284-4289; first published April 4, 2016. https://doi.org/10.1073/pnas.1519630113
Statistics
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  Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks
  Siqi Wu, Antony Joseph, Ann S. Hammonds, Susan E. Celniker, Bin Yu, and Erwin Frise
  
  PNAS April 19, 2016 113 (16) 4290-4295; first published April 6, 2016. https://doi.org/10.1073/pnas.1521171113

Biological Sciences

Anthropology
- Open Access
  Population size does not explain past changes in cultural complexity
  Krist Vaesen, Mark Collard, Richard Cosgrove, and Wil Roebroeks
  
  PNAS April 19, 2016 113 (16) E2241-E2247; first published April 4, 2016. https://doi.org/10.1073/pnas.1520288113
  
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  Reply to Henrich et al.: The Tasmanian effect and other red herrings
  - Nov 01, 2016
Applied Biological Sciences
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  Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction
  Danny Bavli, Sebastian Prill, Elishai Ezra, Gahl Levy, Merav Cohen, Mathieu Vinken, Jan Vanfleteren, Magnus Jaeger, and Yaakov Nahmias
  
  PNAS April 19, 2016 113 (16) E2231-E2240; first published April 4, 2016. https://doi.org/10.1073/pnas.1522556113
Biochemistry
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  Cellular uptake and anticancer activity of carboxylated gallium corroles
  Melanie Pribisko, Joshua Palmer, Robert H. Grubbs, Harry B. Gray, John Termini, and Punnajit Lim
  
  PNAS April 19, 2016 113 (16) E2258-E2266; first published April 4, 2016. https://doi.org/10.1073/pnas.1517402113
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  Functional architecture of the Reb1-Ter complex of Schizosaccharomyces pombe
  Rahul Jaiswal, Malay Choudhury, Shamsu Zaman, Samarendra Singh, Vishaka Santosh, Deepak Bastia, and Carlos R. Escalante
  
  PNAS April 19, 2016 113 (16) E2267-E2276; first published March 28, 2016. https://doi.org/10.1073/pnas.1525465113
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  Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity
  Keriann Oertell, Emily M. Harcourt, Michael G. Mohsen, John Petruska, Eric T. Kool, and Myron F. Goodman
  
  PNAS April 19, 2016 113 (16) E2277-E2285; first published April 4, 2016. https://doi.org/10.1073/pnas.1600279113
- Open Access
  Individual variability in human blood metabolites identifies age-related differences
  Inaugural Article
  
  Romanas Chaleckis, Itsuo Murakami, Junko Takada, Hiroshi Kondoh, and Mitsuhiro Yanagida
  
  PNAS April 19, 2016 113 (16) 4252-4259; first published March 28, 2016. https://doi.org/10.1073/pnas.1603023113
  
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  Reply to Mäkinen and Ala-Korpela: Small-scale but accurate metabolomics with high reproducibility for identifying age-related blood metabolites
  - Jun 21, 2016
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  Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation
  Avital Percher, Srinivasan Ramakrishnan, Emmanuelle Thinon, Xiaoqiu Yuan, Jacob S. Yount, and Howard C. Hang
  
  PNAS April 19, 2016 113 (16) 4302-4307; first published April 4, 2016. https://doi.org/10.1073/pnas.1602244113
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  Mechanism for accurate, protein-assisted DNA annealing by Deinococcus radiodurans DdrB
  Seiji N. Sugiman-Marangos, Yoni M. Weiss, and Murray S. Junop
  
  PNAS April 19, 2016 113 (16) 4308-4313; first published April 4, 2016. https://doi.org/10.1073/pnas.1520847113
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  Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions
  Mira Sohn, Pavlina Ivanova, H. Alex Brown, Daniel J. Toth, Peter Varnai, Yeun Ju Kim, and Tamas Balla
  
  PNAS April 19, 2016 113 (16) 4314-4319; first published April 4, 2016. https://doi.org/10.1073/pnas.1525719113
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  Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function
  Sushabhan Sadhukhan, Xiaojing Liu, Dongryeol Ryu, Ornella D. Nelson, John A. Stupinski, Zhi Li, Wei Chen, Sheng Zhang, Robert S. Weiss, Jason W. Locasale, Johan Auwerx, and Hening Lin
  
  PNAS April 19, 2016 113 (16) 4320-4325; first published April 5, 2016. https://doi.org/10.1073/pnas.1519858113
- Open Access
  Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response
  Anja Reintjes, Julian E. Fuchs, Leopold Kremser, Herbert H. Lindner, Klaus R. Liedl, Lukas A. Huber, and Taras Valovka
  
  PNAS April 19, 2016 113 (16) 4326-4331; first published April 5, 2016. https://doi.org/10.1073/pnas.1522372113
Biophysics and Computational Biology
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  Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding
  Attilio Fabbretti, Andreas Schedlbauer, Letizia Brandi, Tatsuya Kaminishi, Anna Maria Giuliodori, Raffaella Garofalo, Borja Ochoa-Lizarralde, Chie Takemoto, Shigeyuki Yokoyama, Sean R. Connell, Claudio O. Gualerzi, and Paola Fucini
  
  PNAS April 19, 2016 113 (16) E2286-E2295; first published April 6, 2016. https://doi.org/10.1073/pnas.1521156113
- Open Access
  Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex
  Yogambigai Velmurugu, Xuejing Chen, Phillip Slogoff Sevilla, Jung-Hyun Min, and Anjum Ansari
  
  PNAS April 19, 2016 113 (16) E2296-E2305; first published March 31, 2016. https://doi.org/10.1073/pnas.1514666113
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  Surface force measurements and simulations of mussel-derived peptide adhesives on wet organic surfaces
  Zachary A. Levine, Michael V. Rapp, Wei Wei, Ryan Gotchy Mullen, Chun Wu, Gül H. Zerze, Jeetain Mittal, J. Herbert Waite, Jacob N. Israelachvili, and Joan-Emma Shea
  
  PNAS April 19, 2016 113 (16) 4332-4337; first published March 28, 2016. https://doi.org/10.1073/pnas.1603065113
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  Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation
  Chun-Xiao Song, Jiajie Diao, Axel T. Brunger, and Stephen R. Quake
  
  PNAS April 19, 2016 113 (16) 4338-4343; first published March 28, 2016. https://doi.org/10.1073/pnas.1600223113
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  Pathogen receptor discovery with a microfluidic human membrane protein array
  Yair Glick, Ya’ara Ben-Ari, Nir Drayman, Michal Pellach, Gregory Neveu, Jim Boonyaratanakornkit, Dorit Avrahami, Shirit Einav, Ariella Oppenheim, and Doron Gerber
  
  PNAS April 19, 2016 113 (16) 4344-4349; first published April 4, 2016. https://doi.org/10.1073/pnas.1518698113
Cell Biology
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  PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
  Vashe Chandrakanthan, Avani Yeola, Jair C. Kwan, Rema A. Oliver, Qiao Qiao, Young Chan Kang, Peter Zarzour, Dominik Beck, Lies Boelen, Ashwin Unnikrishnan, Jeanette E. Villanueva, Andrea C. Nunez, Kathy Knezevic, Cintia Palu, Rabab Nasrallah, Michael Carnell, Alex Macmillan, Renee Whan, Yan Yu, Philip Hardy, Shane T. Grey, Amadeus Gladbach, Fabien Delerue, Lars Ittner, Ralph Mobbs, Carl R. Walkley, Louise E. Purton, Robyn L. Ward, Jason W. H. Wong, Luke B. Hesson, William Walsh, and John E. Pimanda
  
  PNAS April 19, 2016 113 (16) E2306-E2315; first published April 4, 2016. https://doi.org/10.1073/pnas.1518244113
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  Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation
  Matthew Brook, Gareth H. Tomlinson, Katherine Miles, Richard W. P. Smith, Adriano G. Rossi, Pieter S. Hiemstra, Emily F. A. van ’t Wout, Jonathan L. E. Dean, Nicola K. Gray, Wuyuan Lu, and Mohini Gray
  
  PNAS April 19, 2016 113 (16) 4350-4355; first published April 4, 2016. https://doi.org/10.1073/pnas.1601831113
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  Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis
  Yoichiro Kamimura, Yukihiro Miyanaga, and Masahiro Ueda
  
  PNAS April 19, 2016 113 (16) 4356-4361; first published April 4, 2016. https://doi.org/10.1073/pnas.1516767113
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  Extended synaptotagmins are Ca²⁺-dependent lipid transfer proteins at membrane contact sites
  Haijia Yu, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen
  
  PNAS April 19, 2016 113 (16) 4362-4367; first published April 4, 2016. https://doi.org/10.1073/pnas.1517259113
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  Axial superresolution via multiangle TIRF microscopy with sequential imaging and photobleaching
  Yan Fu, Peter W. Winter, Raul Rojas, Victor Wang, Matthew McAuliffe, and George H. Patterson
  
  PNAS April 19, 2016 113 (16) 4368-4373; first published April 1, 2016. https://doi.org/10.1073/pnas.1516715113
Ecology
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  Slow climate velocities of mountain streams portend their role as refugia for cold-water biodiversity
  Daniel J. Isaak, Michael K. Young, Charles H. Luce, Steven W. Hostetler, Seth J. Wenger, Erin E. Peterson, Jay M. Ver Hoef, Matthew C. Groce, Dona L. Horan, and David E. Nagel
  
  PNAS April 19, 2016 113 (16) 4374-4379; first published April 4, 2016. https://doi.org/10.1073/pnas.1522429113
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  Species interactions slow warming-induced upward shifts of treelines on the Tibetan Plateau
  Eryuan Liang, Yafeng Wang, Shilong Piao, Xiaoming Lu, Jesús Julio Camarero, Haifeng Zhu, Liping Zhu, Aaron M. Ellison, Philippe Ciais, and Josep Peñuelas
  
  PNAS April 19, 2016 113 (16) 4380-4385; first published April 4, 2016. https://doi.org/10.1073/pnas.1520582113
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  Test of the invasive pathogen hypothesis of bumble bee decline in North America
  Sydney A. Cameron, Haw Chuan Lim, Jeffrey D. Lozier, Michelle A. Duennes, and Robbin Thorp
  
  PNAS April 19, 2016 113 (16) 4386-4391; first published April 4, 2016. https://doi.org/10.1073/pnas.1525266113
Environmental Sciences
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  Photodegradation alleviates the lignin bottleneck for carbon turnover in terrestrial ecosystems
  Amy T. Austin, M. Soledad Méndez, and Carlos L. Ballaré
  
  PNAS April 19, 2016 113 (16) 4392-4397; first published April 4, 2016. https://doi.org/10.1073/pnas.1516157113
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  Low rates of nitrogen fixation in eastern tropical South Pacific surface waters
  From the Cover
  
  Angela N. Knapp, Karen L. Casciotti, William M. Berelson, Maria G. Prokopenko, and Douglas G. Capone
  
  PNAS April 19, 2016 113 (16) 4398-4403; first published March 14, 2016. https://doi.org/10.1073/pnas.1515641113
  
  See companion article:
  Elusive marine nitrogen fixation
  - Apr 19, 2016
- Open Access
  Coastal landforms and accumulation of mangrove peat increase carbon sequestration and storage
  From the Cover
  
  Paula Ezcurra, Exequiel Ezcurra, Pedro P. Garcillán, Matthew T. Costa, and Octavio Aburto-Oropeza
  
  PNAS April 19, 2016 113 (16) 4404-4409; first published March 28, 2016. https://doi.org/10.1073/pnas.1519774113
Evolution
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  Tiny individuals attached to a new Silurian arthropod suggest a unique mode of brood care
  Derek E. G. Briggs, Derek J. Siveter, David J. Siveter, Mark D. Sutton, and David Legg
  
  PNAS April 19, 2016 113 (16) 4410-4415; first published April 4, 2016. https://doi.org/10.1073/pnas.1600489113
  
  See companion article:
  Reply to Piper: Aquilonifer’s kites are not mites
  - Jun 14, 2016
- Open Access
  Ancestral genetic diversity associated with the rapid spread of stress-tolerant coral symbionts in response to Holocene climate change
  Benjamin C. C. Hume, Christian R. Voolstra, Chatchanit Arif, Cecilia D’Angelo, John A. Burt, Gal Eyal, Yossi Loya, and Jörg Wiedenmann
  
  PNAS April 19, 2016 113 (16) 4416-4421; first published April 4, 2016. https://doi.org/10.1073/pnas.1601910113
- Open Access
  The effect of gene interactions on the long-term response to selection
  Tiago Paixão and Nicholas H. Barton
  
  PNAS April 19, 2016 113 (16) 4422-4427; first published April 4, 2016. https://doi.org/10.1073/pnas.1518830113
Genetics
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  Interallelic interaction and gene regulation in budding yeast
  Daoyong Zhang and Lu Bai
  
  PNAS April 19, 2016 113 (16) 4428-4433; first published April 4, 2016. https://doi.org/10.1073/pnas.1601003113
- Open Access
  Insight into GATA1 transcriptional activity through interrogation of cis elements disrupted in human erythroid disorders
  Aoi Wakabayashi, Jacob C. Ulirsch, Leif S. Ludwig, Claudia Fiorini, Makiko Yasuda, Avik Choudhuri, Patrick McDonel, Leonard I. Zon, and Vijay G. Sankaran
  
  PNAS April 19, 2016 113 (16) 4434-4439; first published April 4, 2016. https://doi.org/10.1073/pnas.1521754113
Immunology and Inflammation
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  Nuclear transfer nTreg model reveals fate-determining TCR-β and novel peripheral nTreg precursors
  Manching Ku, Shih-En Chang, Julio Hernandez, Justin R. Abadejos, Mohsen Sabouri-Ghomi, Niklas J. Muenchmeier, Anna Schwarz, Anna M. Valencia, and Oktay Kirak
  
  PNAS April 19, 2016 113 (16) E2316-E2325; first published April 4, 2016. https://doi.org/10.1073/pnas.1523664113
- Open Access
  Molecular basis for universal HLA-A*0201–restricted CD8⁺ T-cell immunity against influenza viruses
  Sophie A. Valkenburg, Tracy M. Josephs, E. Bridie Clemens, Emma J. Grant, Thi H. O. Nguyen, George C. Wang, David A. Price, Adrian Miller, Steven Y. C. Tong, Paul G. Thomas, Peter C. Doherty, Jamie Rossjohn, Stephanie Gras, and Katherine Kedzierska
  
  PNAS April 19, 2016 113 (16) 4440-4445; first published March 31, 2016. https://doi.org/10.1073/pnas.1603106113
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  Long antibody HCDR3s from HIV-naïve donors presented on a PG9 neutralizing antibody background mediate HIV neutralization
  Jordan R. Willis, Jessica A. Finn, Bryan Briney, Gopal Sapparapu, Vidisha Singh, Hannah King, Celia C. LaBranche, David C. Montefiori, Jens Meiler, and James E. Crowe Jr.
  
  PNAS April 19, 2016 113 (16) 4446-4451; first published April 4, 2016. https://doi.org/10.1073/pnas.1518405113
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  NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β–mediated osteomyelitis
  Prajwal Gurung, Amanda Burton, and Thirumala-Devi Kanneganti
  
  PNAS April 19, 2016 113 (16) 4452-4457; first published April 6, 2016. https://doi.org/10.1073/pnas.1601636113
- Open Access
  Monoclonal antibody therapy for Junin virus infection
  Larry Zeitlin, Joan B. Geisbert, Daniel J. Deer, Karla A. Fenton, Ognian Bohorov, Natasha Bohorova, Charles Goodman, Do Kim, Andrew Hiatt, Michael H. Pauly, Jesus Velasco, Kevin J. Whaley, Friedrich Altmann, Clemens Gruber, Herta Steinkellner, Anna N. Honko, Ana I. Kuehne, M. Javad Aman, Sara Sahandi, Sven Enterlein, Xiaoguo Zhan, Delia Enria, and Thomas W. Geisbert
  
  PNAS April 19, 2016 113 (16) 4458-4463; first published April 4, 2016. https://doi.org/10.1073/pnas.1600996113
Medical Sciences
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  Identification of tumorigenic cells and therapeutic targets in pancreatic neuroendocrine tumors
  Geoffrey Wayne Krampitz, Benson M. George, Stephen B. Willingham, Jens-Peter Volkmer, Kipp Weiskopf, Nadine Jahchan, Aaron M. Newman, Debashis Sahoo, Allison J. Zemek, Rebecca L. Yanovsky, Julia K. Nguyen, Peter J. Schnorr, Pawel K. Mazur, Julien Sage, Teri A. Longacre, Brendan C. Visser, George A. Poultsides, Jeffrey A. Norton, and Irving L. Weissman
  
  PNAS April 19, 2016 113 (16) 4464-4469; first published March 31, 2016. https://doi.org/10.1073/pnas.1600007113
- Open Access
  Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
  Teresa E. Peterson, Nathaniel D. Kirkpatrick, Yuhui Huang, Christian T. Farrar, Koen A. Marijt, Jonas Kloepper, Meenal Datta, Zohreh Amoozgar, Giorgio Seano, Keehoon Jung, Walid S. Kamoun, Trupti Vardam, Matija Snuderl, Jermaine Goveia, Sampurna Chatterjee, Ana Batista, Alona Muzikansky, Ching Ching Leow, Lei Xu, Tracy T. Batchelor, Dan G. Duda, Dai Fukumura, and Rakesh K. Jain
  
  PNAS April 19, 2016 113 (16) 4470-4475; first published April 4, 2016. https://doi.org/10.1073/pnas.1525349113
  
  See companion article:
  Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
  - Apr 19, 2016
- Open Access
  Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
  Jonas Kloepper, Lars Riedemann, Zohreh Amoozgar, Giorgio Seano, Katharina Susek, Veronica Yu, Nisha Dalvie, Robin L. Amelung, Meenal Datta, Jonathan W. Song, Vasileios Askoxylakis, Jennie W. Taylor, Christine Lu-Emerson, Ana Batista, Nathaniel D. Kirkpatrick, Keehoon Jung, Matija Snuderl, Alona Muzikansky, Kay G. Stubenrauch, Oliver Krieter, Hiroaki Wakimoto, Lei Xu, Lance L. Munn, Dan G. Duda, Dai Fukumura, Tracy T. Batchelor, and Rakesh K. Jain
  
  PNAS April 19, 2016 113 (16) 4476-4481; first published April 4, 2016. https://doi.org/10.1073/pnas.1525360113
  
  See companion article:
  Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
  - Apr 19, 2016
- Open Access
  Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay
  Jung Wook Park, John K. Lee, John W. Phillips, Patrick Huang, Donghui Cheng, Jiaoti Huang, and Owen N. Witte
  
  PNAS April 19, 2016 113 (16) 4482-4487; first published April 4, 2016. https://doi.org/10.1073/pnas.1603645113
- Open Access
  Transmission dynamics of Ebola virus disease and intervention effectiveness in Sierra Leone
  Li-Qun Fang, Yang Yang, Jia-Fu Jiang, Hong-Wu Yao, David Kargbo, Xin-Lou Li, Bao-Gui Jiang, Brima Kargbo, Yi-Gang Tong, Ya-Wei Wang, Kun Liu, Abdul Kamara, Foday Dafae, Alex Kanu, Rui-Ruo Jiang, Ye Sun, Ruo-Xi Sun, Wan-Jun Chen, Mai-Juan Ma, Natalie E. Dean, Harold Thomas, Ira M. Longini Jr., M. Elizabeth Halloran, and Wu-Chun Cao
  
  PNAS April 19, 2016 113 (16) 4488-4493; first published March 28, 2016. https://doi.org/10.1073/pnas.1518587113
Microbiology
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  Discovery of unfixed endogenous retrovirus insertions in diverse human populations
  From the Cover
  
  Julia Halo Wildschutte, Zachary H. Williams, Meagan Montesion, Ravi P. Subramanian, Jeffrey M. Kidd, and John M. Coffin
  
  PNAS April 19, 2016 113 (16) E2326-E2334; first published March 21, 2016. https://doi.org/10.1073/pnas.1602336113
  
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  HERV-K HML-2 diversity among humans
  - Apr 19, 2016
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  Proteus mirabilis fimbriae- and urease-dependent clusters assemble in an extracellular niche to initiate bladder stone formation
  Jessica N. Schaffer, Allison N. Norsworthy, Tung-Tien Sun, and Melanie M. Pearson
  
  PNAS April 19, 2016 113 (16) 4494-4499; first published April 4, 2016. https://doi.org/10.1073/pnas.1601720113
Neuroscience
- Open Access
  A neural link between affective understanding and interpersonal attraction
  Silke Anders, Roos de Jong, Christian Beck, John-Dylan Haynes, and Thomas Ethofer
  
  PNAS April 19, 2016 113 (16) E2248-E2257; first published April 4, 2016. https://doi.org/10.1073/pnas.1516191113
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  Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
  Dylan G. Gee, Robert N. Fetcho, Deqiang Jing, Anfei Li, Charles E. Glatt, Andrew T. Drysdale, Alexandra O. Cohen, Danielle V. Dellarco, Rui R. Yang, Anders M. Dale, Terry L. Jernigan, Francis S. Lee, B.J. Casey, and the PING Consortium
  
  PNAS April 19, 2016 113 (16) 4500-4505; first published March 21, 2016. https://doi.org/10.1073/pnas.1600013113
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  Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRα3
  Erika K. Lippoldt, Serra Ongun, Geoffrey K. Kusaka, and David D. McKemy
  
  PNAS April 19, 2016 113 (16) 4506-4511; first published April 5, 2016. https://doi.org/10.1073/pnas.1603294113
- You have access
  Functional network inference of the suprachiasmatic nucleus
  John H. Abel, Kirsten Meeker, Daniel Granados-Fuentes, Peter C. St. John, Thomas J. Wang, Benjamin B. Bales, Francis J. Doyle III, Erik D. Herzog, and Linda R. Petzold
  
  PNAS April 19, 2016 113 (16) 4512-4517; first published April 4, 2016. https://doi.org/10.1073/pnas.1521178113
- Open Access
  Tracking brain arousal fluctuations with fMRI
  Catie Chang, David A. Leopold, Marieke Louise Schölvinck, Hendrik Mandelkow, Dante Picchioni, Xiao Liu, Frank Q. Ye, Janita N. Turchi, and Jeff H. Duyn
  
  PNAS April 19, 2016 113 (16) 4518-4523; first published April 5, 2016. https://doi.org/10.1073/pnas.1520613113
Pharmacology
- Open Access
  Mapping physiological G protein-coupled receptor signaling pathways reveals a role for receptor phosphorylation in airway contraction
  Sophie J. Bradley, Coen H. Wiegman, Max Maza Iglesias, Kok Choi Kong, Adrian J. Butcher, Bianca Plouffe, Eugénie Goupil, Julie-Myrtille Bourgognon, Timothy Macedo-Hatch, Christian LeGouill, Kirsty Russell, Stéphane A. Laporte, Gabriele M. König, Evi Kostenis, Michel Bouvier, Kian Fan Chung, Yassine Amrani, and Andrew B. Tobin
  
  PNAS April 19, 2016 113 (16) 4524-4529; first published April 8, 2016. https://doi.org/10.1073/pnas.1521706113
Physiology
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  BK_Ca channel regulates calcium oscillations induced by alpha-2-macroglobulin in human myometrial smooth muscle cells
  Monali Wakle-Prabagaran, Ramón A. Lorca, Xiaofeng Ma, Susan J. Stamnes, Chinwendu Amazu, Jordy J. Hsiao, Celeste M. Karch, Krzysztof L. Hyrc, Michael E. Wright, and Sarah K. England
  
  PNAS April 19, 2016 113 (16) E2335-E2344; first published April 4, 2016. https://doi.org/10.1073/pnas.1516863113
Psychological and Cognitive Sciences
- Open Access
  Culture shapes the evolution of cognition
  Bill Thompson, Simon Kirby, and Kenny Smith
  
  PNAS April 19, 2016 113 (16) 4530-4535; first published April 4, 2016. https://doi.org/10.1073/pnas.1523631113
Sustainability Science
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  Tradeoffs between fisheries harvest and the resilience of coral reefs
  Yves-Marie Bozec, Shay O'Farrell, J. Henrich Bruggemann, Brian E. Luckhurst, and Peter J. Mumby
  
  PNAS April 19, 2016 113 (16) 4536-4541; first published April 4, 2016. https://doi.org/10.1073/pnas.1601529113
Systems Biology
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  Stability-driven nonnegative matrix factorization to interpret spatial gene expression and build local gene networks
  Siqi Wu, Antony Joseph, Ann S. Hammonds, Susan E. Celniker, Bin Yu, and Erwin Frise
  
  PNAS April 19, 2016 113 (16) 4290-4295; first published April 6, 2016. https://doi.org/10.1073/pnas.1521171113

Corrections (Online Only)

You have access
Correction for Venton, Inner Workings: Exploring ancient storms in marshes, corals, and caves
PNAS April 19, 2016 113 (16) E2345; first published April 11, 2016. https://doi.org/10.1073/pnas.1605200113
You have access
Correction for Springer and Sen, Leukocyte integrin α_Lβ₂ headpiece structures: The αI domain, the pocket for the internal ligand, and concerted movements of its loops
PNAS April 19, 2016 113 (16) E2346; first published April 11, 2016. https://doi.org/10.1073/pnas.1604535113
You have access
Correction for Lee et al., Shox2 is a molecular determinant of depot-specific adipocyte function
PNAS April 19, 2016 113 (16) E2347; first published April 11, 2016. https://doi.org/10.1073/pnas.1604718113

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