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Research Article

Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species

Dylan G. Gee, Robert N. Fetcho, Deqiang Jing, Anfei Li, Charles E. Glatt, Andrew T. Drysdale, Alexandra O. Cohen, Danielle V. Dellarco, Rui R. Yang, Anders M. Dale, Terry L. Jernigan, Francis S. Lee, B.J. Casey, and the PING Consortium
PNAS April 19, 2016 113 (16) 4500-4505; first published March 21, 2016; https://doi.org/10.1073/pnas.1600013113
Dylan G. Gee
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Robert N. Fetcho
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Deqiang Jing
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Anfei Li
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Charles E. Glatt
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Andrew T. Drysdale
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Alexandra O. Cohen
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Danielle V. Dellarco
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Rui R. Yang
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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Anders M. Dale
cDepartments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA 92093;
dDepartment of Cognitive Science, University of California, San Diego, CA 92093;
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Terry L. Jernigan
dDepartment of Cognitive Science, University of California, San Diego, CA 92093;
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Francis S. Lee
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
eDepartment of Pharmacology, Weill Cornell Medical College of Cornell University, New York, NY 10065
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  • For correspondence: fslee@med.cornell.edu bjc2002@med.cornell.edu
B.J. Casey
aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
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  • For correspondence: fslee@med.cornell.edu bjc2002@med.cornell.edu
  1. Edited by Michael I. Posner, University of Oregon, Eugene, OR, and approved February 17, 2016 (received for review January 2, 2016)

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Article Information

vol. 113 no. 16 4500-4505
DOI: 
https://doi.org/10.1073/pnas.1600013113
PubMed: 
27001846

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue April 19, 2016.
  • Published first March 21, 2016.


Author Information

  1. Dylan G. Geea,b,1,
  2. Robert N. Fetchoa,1,
  3. Deqiang Jingb,1,
  4. Anfei Lia,1,
  5. Charles E. Glatta,b,
  6. Andrew T. Drysdalea,
  7. Alexandra O. Cohena,b,
  8. Danielle V. Dellarcoa,b,
  9. Rui R. Yangb,
  10. Anders M. Dalec,d,
  11. Terry L. Jernigand,
  12. Francis S. Leea,b,e,2,3,
  13. B.J. Caseya,b,2,3,
  14. the PING Consortium4
  1. aSackler Institute for Developmental Psychobiology, Weill Cornell Medical College of Cornell University, New York, NY 10065;
  2. bDepartment of Psychiatry, Weill Cornell Medical College of Cornell University, New York, NY 10065;
  3. cDepartments of Neurosciences, Radiology, and Psychiatry, University of California, San Diego, CA 92093;
  4. dDepartment of Cognitive Science, University of California, San Diego, CA 92093;
  5. eDepartment of Pharmacology, Weill Cornell Medical College of Cornell University, New York, NY 10065
                        1. Edited by Michael I. Posner, University of Oregon, Eugene, OR, and approved February 17, 2016 (received for review January 2, 2016)

                        Footnotes

                        • ↵1D.G.G., R.N.F., D.J., and A.L. contributed equally to this work.

                        • ↵2F.S.L. and B.J.C. contributed equally to this work.

                        • ↵3To whom correspondence may be addressed. Email: fslee{at}med.cornell.edu or bjc2002{at}med.cornell.edu.
                        • ↵4A complete list of the PING Consortium can be found in Supporting Information.

                        • Author contributions: F.S.L. and B.J.C. designed research; D.J., A.L., D.V.D., R.R.Y., T.L.J., B.J.C., and P.C. performed research; D.G.G., R.N.F., D.J., A.L., C.E.G., A.T.D., A.O.C., R.R.Y., and A.M.D. analyzed data; and D.G.G., R.N.F., C.E.G., F.S.L., and B.J.C. wrote the paper.

                        • The authors declare no conflict of interest.

                        • This article is a PNAS Direct Submission.

                        • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1600013113/-/DCSupplemental.

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                        Article usage

                        Article usage: March 2016 to January 2021

                        AbstractFullPdf
                        Mar 20163849111211
                        Apr 20166511120301
                        May 201611495399
                        Jun 20164202626
                        Jul 20162152120
                        Aug 20162421221
                        Sep 20162182127
                        Oct 20161995241
                        Nov 20162157534
                        Dec 20162003528
                        Total 201613218526808
                        Jan 20171643928
                        Feb 20171979429
                        Mar 20171405317
                        Apr 20171811714
                        May 20171032818
                        Jun 2017803125
                        Jul 2017965024
                        Aug 2017913419
                        Sep 2017654330
                        Oct 2017713912
                        Nov 2017634922
                        Dec 2017552814
                        Total 20171306505252
                        Jan 2018494413
                        Feb 201832386
                        Mar 2018546514
                        Apr 201852619
                        May 2018789720
                        Jun 201872839
                        Jul 201836424
                        Aug 201847515
                        Sep 201839416
                        Oct 2018105116
                        Nov 2018316026
                        Dec 201826813
                        Total 2018474801141
                        Jan 20191017211
                        Feb 201917849
                        Mar 2019108318
                        Apr 2019159727
                        May 2019149218
                        Jun 201967214
                        Jul 201947517
                        Aug 201927715
                        Sep 2019418234
                        Oct 201999118
                        Nov 201947419
                        Dec 2019115713
                        Total 20191431056213
                        Jan 2020146813
                        Feb 2020168019
                        Mar 2020128019
                        Apr 20202110336
                        May 2020107323
                        Jun 202066410
                        Jul 20208746
                        Aug 202036611
                        Sep 20201317715
                        Oct 20201810920
                        Nov 2020209426
                        Dec 2020197914
                        Total 20201601067212
                        Jan 2021136715
                        Total 2021136715
                        Total1531440221641
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                        Variation in frontolimbic development and anxiety
                        Dylan G. Gee, Robert N. Fetcho, Deqiang Jing, Anfei Li, Charles E. Glatt, Andrew T. Drysdale, Alexandra O. Cohen, Danielle V. Dellarco, Rui R. Yang, Anders M. Dale, Terry L. Jernigan, Francis S. Lee, B.J. Casey, the PING Consortium
                        Proceedings of the National Academy of Sciences Apr 2016, 113 (16) 4500-4505; DOI: 10.1073/pnas.1600013113

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                        Variation in frontolimbic development and anxiety
                        Dylan G. Gee, Robert N. Fetcho, Deqiang Jing, Anfei Li, Charles E. Glatt, Andrew T. Drysdale, Alexandra O. Cohen, Danielle V. Dellarco, Rui R. Yang, Anders M. Dale, Terry L. Jernigan, Francis S. Lee, B.J. Casey, the PING Consortium
                        Proceedings of the National Academy of Sciences Apr 2016, 113 (16) 4500-4505; DOI: 10.1073/pnas.1600013113
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