Table of Contents

Biological Sciences

• Agricultural Sciences

  • You have access

    Boundary work for sustainable development: Natural resource management at the Consultative Group on International Agricultural Research (CGIAR)

    • Inaugural Article

    William C. Clark, Thomas P. Tomich, Meine van Noordwijk, David Guston, Delia Catacutan, Nancy M. Dickson, and Elizabeth McNie

    PNAS April 26, 2016 113 (17) 4615-4622; published ahead of print August 15, 2011. https://doi.org/10.1073/pnas.0900231108

• Anthropology

  • You have access

    Reproductive trade-offs in extant hunter-gatherers suggest adaptive mechanism for the Neolithic expansion

    Abigail E. Page, Sylvain Viguier, Mark Dyble, Daniel Smith, Nikhil Chaudhary, Gul Deniz Salali, James Thompson, Lucio Vinicius, Ruth Mace, and Andrea Bamberg Migliano

    PNAS April 26, 2016 113 (17) 4694-4699; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1524031113

• Applied Biological Sciences

  • You have access

    Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

    Arnab Ghosh, Cynthia J. Koziol-White, Kewal Asosingh, Georgina Cheng, Lisa Ruple, Dieter Groneberg, Andreas Friebe, Suzy A. A. Comhair, Johannes-Peter Stasch, Reynold A. Panettieri Jr., Mark A. Aronica, Serpil C. Erzurum, and Dennis J. Stuehr

    PNAS April 26, 2016 113 (17) E2355-E2362; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1524398113

• Biochemistry

  • You have access

    Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant

    Mahmud Arif Pavel, Caixia Lv, Courtney Ng, Lei Yang, Parul Kashyap, Clarissa Lam, Victoria Valentino, Helen Y. Fung, Thomas Campbell, Simon Geir Møller, David Zenisek, Nathalia G. Holtzman, and Yong Yu

    PNAS April 26, 2016 113 (17) E2363-E2372; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1517066113
  • You have access

    Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster

    Geoffrey D. Shimberg, Jamie L. Michalek, Abdulafeez A. Oluyadi, Andria V. Rodrigues, Beth E. Zucconi, Heather M. Neu, Shanchari Ghosh, Kanisha Sureschandra, Gerald M. Wilson, Timothy L. Stemmler, and Sarah L. J. Michel

    PNAS April 26, 2016 113 (17) 4700-4705; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1517620113
  • You have access

    Nucleotide excision repair by dual incisions in plants

    Fazile Canturk, Muhammet Karaman, Christopher P. Selby, Michael G. Kemp, Gulnihal Kulaksiz-Erkmen, Jinchuan Hu, Wentao Li, Laura A. Lindsey-Boltz, and Aziz Sancar

    PNAS April 26, 2016 113 (17) 4706-4710; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1604097113
  • You have access

    Mechanism of inhibition of human glucose transporter GLUT1 is conserved between cytochalasin B and phenylalanine amides

    Khyati Kapoor, Janet S. Finer-Moore, Bjørn P. Pedersen, Laura Caboni, Andrew Waight, Roman C. Hillig, Peter Bringmann, Iring Heisler, Thomas Müller, Holger Siebeneicher, and Robert M. Stroud

    PNAS April 26, 2016 113 (17) 4711-4716; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1603735113
  • You have access

    Apicomplexa-specific tRip facilitates import of exogenous tRNAs into malaria parasites

    Tania Bour, Nassira Mahmoudi, Delphine Kapps, Sabine Thiberge, Daniel Bargieri, Robert Ménard, and Magali Frugier

    PNAS April 26, 2016 113 (17) 4717-4722; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1600476113
  • Open Access

    Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance

    Matilda Rentoft, Kristoffer Lindell, Phong Tran, Anna Lena Chabes, Robert J. Buckland, Danielle L. Watt, Lisette Marjavaara, Anna Karin Nilsson, Beatrice Melin, Johan Trygg, Erik Johansson, and Andrei Chabes

    PNAS April 26, 2016 113 (17) 4723-4728; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1519128113

• Biophysics and Computational Biology

  • You have access

    Molecular circuits for dynamic noise filtering

    Christoph Zechner, Georg Seelig, Marc Rullan, and Mustafa Khammash

    PNAS April 26, 2016 113 (17) 4729-4734; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1517109113
  • Open Access

    Dynamical network of residue–residue contacts reveals coupled allosteric effects in recognition, catalysis, and mutation

    Urmi Doshi, Michael J. Holliday, Elan Z. Eisenmesser, and Donald Hamelberg

    PNAS April 26, 2016 113 (17) 4735-4740; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1523573113
  • You have access

    Conductance of P2X₄ purinergic receptor is determined by conformational equilibrium in the transmembrane region

    Yuichi Minato, Shiho Suzuki, Tomoaki Hara, Yutaka Kofuku, Go Kasuya, Yuichiro Fujiwara, Shunsuke Igarashi, Ei-ichiro Suzuki, Osamu Nureki, Motoyuki Hattori, Takumi Ueda, and Ichio Shimada

    PNAS April 26, 2016 113 (17) 4741-4746; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1600519113
  • You have access

    Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange

    Wookyung Yu, Michael C. Baxa, Isabelle Gagnon, Karl F. Freed, and Tobin R. Sosnick

    PNAS April 26, 2016 113 (17) 4747-4752; published ahead of print April 13, 2016. https://doi.org/10.1073/pnas.1522500113
  • Open Access

    A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

    Prajwal Ciryam, Rishika Kundra, Rosie Freer, Richard I. Morimoto, Christopher M. Dobson, and Michele Vendruscolo

    PNAS April 26, 2016 113 (17) 4753-4758; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1516604113

• Cell Biology

  • You have access

    Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling

    Giovanna Morello, Roberta Imperatore, Letizia Palomba, Carmine Finelli, Giuseppe Labruna, Fabrizio Pasanisi, Lucia Sacchetti, Lorena Buono, Fabiana Piscitelli, Pierangelo Orlando, Vincenzo Di Marzo, and Luigia Cristino

    PNAS April 26, 2016 113 (17) 4759-4764; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1521304113

• Ecology

  • You have access

    Predictable evolution toward flightlessness in volant island birds

    Natalie A. Wright, David W. Steadman, and Christopher C. Witt

    PNAS April 26, 2016 113 (17) 4765-4770; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1522931113

• Evolution

  • You have access

    Recurrent specialization on a toxic fruit in an island Drosophila population

    • From the Cover

    Amir Yassin, Vincent Debat, Héloïse Bastide, Nelly Gidaszewski, Jean R. David, and John E. Pool

    PNAS April 26, 2016 113 (17) 4771-4776; published ahead of print April 4, 2016. https://doi.org/10.1073/pnas.1522559113

• Genetics

  • Open Access

    The tandem duplicator phenotype as a distinct genomic configuration in cancer

    Francesca Menghi, Koichiro Inaki, XingYi Woo, Pooja A. Kumar, Krzysztof R. Grzeda, Ankit Malhotra, Vinod Yadav, Hyunsoo Kim, Eladio J. Marquez, Duygu Ucar, Phung T. Shreckengast, Joel P. Wagner, George MacIntyre, Krishna R. Murthy Karuturi, Ralph Scully, James Keck, Jeffrey H. Chuang, and Edison T. Liu

    PNAS April 26, 2016 113 (17) E2373-E2382; published ahead of print April 7, 2016. https://doi.org/10.1073/pnas.1520010113

• Immunology and Inflammation

  • You have access

    Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

    Katrin Klocke, Shimon Sakaguchi, Rikard Holmdahl, and Kajsa Wing

    PNAS April 26, 2016 113 (17) E2383-E2392; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1603892113
  • Open Access

    Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system

    Alexis Vandenbon, Viet H. Dinh, Norihisa Mikami, Yohko Kitagawa, Shunsuke Teraguchi, Naganari Ohkura, and Shimon Sakaguchi

    PNAS April 26, 2016 113 (17) E2393-E2402; published ahead of print April 13, 2016. https://doi.org/10.1073/pnas.1604351113
  • Open Access

    Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2

    Ulf Schulze-Topphoff, Michel Varrin-Doyer, Kara Pekarek, Collin M. Spencer, Aparna Shetty, Sharon A. Sagan, Bruce A. C. Cree, Raymond A. Sobel, Brian T. Wipke, Lawrence Steinman, Robert H. Scannevin, and Scott S. Zamvil

    PNAS April 26, 2016 113 (17) 4777-4782; published ahead of print April 13, 2016. https://doi.org/10.1073/pnas.1603907113

• Medical Sciences

  • You have access

    In vitro system using human neurons demonstrates that varicella-zoster vaccine virus is impaired for reactivation, but not latency

    Tomohiko Sadaoka, Daniel P. Depledge, Labchan Rajbhandari, Arun Venkatesan, Judith Breuer, and Jeffrey I. Cohen

    PNAS April 26, 2016 113 (17) E2403-E2412; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1522575113

• Microbiology

  • You have access

    Internal and external components of the bacterial flagellar motor rotate as a unit

    Basarab G. Hosu, Vedavalli S. J. Nathan, and Howard C. Berg

    PNAS April 26, 2016 113 (17) 4783-4787; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1511691113
  • You have access

    Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

    Monica Markovski, Jessica L. Bohrhunter, Tania J. Lupoli, Tsuyoshi Uehara, Suzanne Walker, Daniel E. Kahne, and Thomas G. Bernhardt

    PNAS April 26, 2016 113 (17) 4788-4793; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1524538113
  • You have access

    The type III secretion system apparatus determines the intracellular niche of bacterial pathogens

    Juan Du, Analise Z. Reeves, Jessica A. Klein, Donna J. Twedt, Leigh A. Knodler, and Cammie F. Lesser

    PNAS April 26, 2016 113 (17) 4794-4799; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1520699113
  • Open Access

    Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages

    Megan Dearnley, Trang Chu, Yao Zhang, Oliver Looker, Changjin Huang, Nectarios Klonis, Jeff Yeoman, Shannon Kenny, Mohit Arora, James M. Osborne, Rajesh Chandramohanadas, Sulin Zhang, Matthew W. A. Dixon, and Leann Tilley

    PNAS April 26, 2016 113 (17) 4800-4805; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1520194113
  • Open Access

    The pupylation machinery is involved in iron homeostasis by targeting the iron storage protein ferritin

    Andreas Küberl, Tino Polen, and Michael Bott

    PNAS April 26, 2016 113 (17) 4806-4811; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1514529113

• Neuroscience

  • You have access

    Covert neurofeedback without awareness shapes cortical network spontaneous connectivity

    Michal Ramot, Shany Grossman, Doron Friedman, and Rafael Malach

    PNAS April 26, 2016 113 (17) E2413-E2420; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1516857113
  • You have access

    Intrathecal gene therapy rescues a model of demyelinating peripheral neuropathy

    • From the Cover

    Alexia Kagiava, Irene Sargiannidou, George Theophilidis, Christos Karaiskos, Jan Richter, Stavros Bashiardes, Natasa Schiza, Marianna Nearchou, Christina Christodoulou, Steven S. Scherer, and Kleopas A. Kleopa

    PNAS April 26, 2016 113 (17) E2421-E2429; published ahead of print March 28, 2016. https://doi.org/10.1073/pnas.1522202113
  • You have access

    Dominant hemisphere lateralization of cortical parasympathetic control as revealed by frontotemporal dementia

    Christine C. Guo, Virginia E. Sturm, Juan Zhou, Efstathios D. Gennatas, Andrew J. Trujillo, Alice Y. Hua, Richard Crawford, Lara Stables, Joel H. Kramer, Katherine Rankin, Robert W. Levenson, Howard J. Rosen, Bruce L. Miller, and William W. Seeley

    PNAS April 26, 2016 113 (17) E2430-E2439; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1509184113
  • Open Access

    A descending dopamine pathway conserved from basal vertebrates to mammals

    Dimitri Ryczko, Jackson J. Cone, Michael H. Alpert, Laurent Goetz, François Auclair, Catherine Dubé, Martin Parent, Mitchell F. Roitman, Simon Alford, and Réjean Dubuc

    PNAS April 26, 2016 113 (17) E2440-E2449; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1600684113
  • Open Access

    Stimulus features coded by single neurons of a macaque body category selective patch

    Ivo D. Popivanov, Philippe G. Schyns, and Rufin Vogels

    PNAS April 26, 2016 113 (17) E2450-E2459; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1520371113
  • Open Access

    Striatal structure and function predict individual biases in learning to avoid pain

    Eran Eldar, Tobias U. Hauser, Peter Dayan, and Raymond J. Dolan

    PNAS April 26, 2016 113 (17) 4812-4817; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1519829113
  • You have access

    Short and long-lasting behavioral consequences of agonistic encounters between male Drosophila melanogaster

    Séverine Trannoy, Jill Penn, Kenia Lucey, David Popovic, and Edward A. Kravitz

    PNAS April 26, 2016 113 (17) 4818-4823; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1520953113
  • You have access

    Contrasting variability patterns in the default mode and sensorimotor networks balance in bipolar depression and mania

    Matteo Martino, Paola Magioncalda, Zirui Huang, Benedetta Conio, Niccolò Piaggio, Niall W. Duncan, Giulio Rocchi, Andrea Escelsior, Valentina Marozzi, Annemarie Wolff, Matilde Inglese, Mario Amore, and Georg Northoff

    PNAS April 26, 2016 113 (17) 4824-4829; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1517558113
  • You have access

    Stress-induced gene expression and behavior are controlled by DNA methylation and methyl donor availability in the dentate gyrus

    Emily A. Saunderson, Helen Spiers, Karen R. Mifsud, Maria Gutierrez-Mecinas, Alexandra F. Trollope, Abeera Shaikh, Jonathan Mill, and Johannes M. H. M. Reul

    PNAS April 26, 2016 113 (17) 4830-4835; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1524857113
  • Open Access

    Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain

    Janet E. Baulch, Munjal M. Acharya, Barrett D. Allen, Ning Ru, Nicole N. Chmielewski, Vahan Martirosian, Erich Giedzinski, Amber Syage, Audrey L. Park, Sarah N. Benke, Vipan K. Parihar, and Charles L. Limoli

    PNAS April 26, 2016 113 (17) 4836-4841; published ahead of print April 4, 2016. https://doi.org/10.1073/pnas.1521668113
  • Open Access

    Prestimulus influences on auditory perception from sensory representations and decision processes

    Stephanie J. Kayser, Steven W. McNair, and Christoph Kayser

    PNAS April 26, 2016 113 (17) 4842-4847; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1524087113
  • Open Access

    Echolocating bats use future-target information for optimal foraging

    Emyo Fujioka, Ikkyu Aihara, Miwa Sumiya, Kazuyuki Aihara, and Shizuko Hiryu

    PNAS April 26, 2016 113 (17) 4848-4852; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1515091113
  • Open Access

    Neural correlates of the LSD experience revealed by multimodal neuroimaging

    Robin L. Carhart-Harris, Suresh Muthukumaraswamy, Leor Roseman, Mendel Kaelen, Wouter Droog, Kevin Murphy, Enzo Tagliazucchi, Eduardo E. Schenberg, Timothy Nest, Csaba Orban, Robert Leech, Luke T. Williams, Tim M. Williams, Mark Bolstridge, Ben Sessa, John McGonigle, Martin I. Sereno, David Nichols, Peter J. Hellyer, Peter Hobden, John Evans, Krish D. Singh, Richard G. Wise, H. Valerie Curran, Amanda Feilding, and David J. Nutt

    PNAS April 26, 2016 113 (17) 4853-4858; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1518377113

• Pharmacology

  • You have access

    In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide

    Michel Ronjat, Wei Feng, Lucie Dardevet, Yao Dong, Sawsan Al Khoury, Franck C. Chatelain, Virginie Vialla, Samir Chahboun, Florian Lesage, Hervé Darbon, Isaac N. Pessah, and Michel De Waard

    PNAS April 26, 2016 113 (17) E2460-E2468; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1517342113

• Physiology

  • You have access

    Cotranslational association of mRNA encoding subunits of heteromeric ion channels

    Fang Liu, David K. Jones, Willem J. de Lange, and Gail A. Robertson

    PNAS April 26, 2016 113 (17) 4859-4864; published ahead of print April 12, 2016. https://doi.org/10.1073/pnas.1521577113

• Plant Biology

  • You have access

    Revealing catastrophic failure of leaf networks under stress

    Timothy J. Brodribb, Diane Bienaimé, and Philippe Marmottant

    PNAS April 26, 2016 113 (17) 4865-4869; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1522569113
  • You have access

    Molecular convergence of clock and photosensory pathways through PIF3–TOC1 interaction and co-occupancy of target promoters

    Judit Soy, Pablo Leivar, Nahuel González-Schain, Guiomar Martín, Céline Diaz, Maria Sentandreu, Bassem Al-Sady, Peter H. Quail, and Elena Monte

    PNAS April 26, 2016 113 (17) 4870-4875; published ahead of print April 11, 2016. https://doi.org/10.1073/pnas.1603745113

• Sustainability Science

  • You have access

    Evolution of models to support community and policy action with science: Balancing pastoral livelihoods and wildlife conservation in savannas of East Africa

    R. S. Reid, D. Nkedianye, M. Y. Said, D. Kaelo, M. Neselle, O. Makui, L. Onetu, S. Kiruswa, N. Ole Kamuaro, P. Kristjanson, J. Ogutu, S. B. BurnSilver, M. J. Goldman, R. B. Boone, K. A. Galvin, N. M. Dickson, and W. C. Clark

    PNAS April 26, 2016 113 (17) 4579-4584; published ahead of print November 3, 2009. https://doi.org/10.1073/pnas.0900313106