Researchers reveal key details of how the heat shock protein mechanism disassembles the α-synuclein amyloids linked to Parkinson’s disease.
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Edited by Susan T. Fiske, Princeton University, Princeton, NJ, and approved April 19, 2016 (received for review November 29, 2015)
Article Figures & SI
Figures
- Fig. S1.
Mean reported memory (AMQ) by cheating in study 2.
- Fig. S2.
Mean reported memory (AMQ) by condition in study 3.
- Fig. 1.
Mean reported memory (AMQ) by condition in study 4. *P ≤ 0.05.
- Fig. S3.
The Boggle task used in study 7b: a copy of the screen participants saw in the instruction phase.
Tables
Measures Unethical Ethical Negative Positive Neutral Clarity 5.38 (1.17)a 6.00 (0.88)b 5.90 (0.91)b 5.99 (0.86)b 5.98 (0.90)b Sensory 3.07 (1.60)a 3.53 (1.56)a,b 3.14 (1.69)a 3.53 (1.83)a,b 3.83 (1.85)b Time context 4.84 (1.29)a 5.42 (1.32)b 5.38 (1.41)b 5.61 (1.30)b 5.69 (1.22)b Spatial context 5.53 (1.18)a 5.91 (1.07)b 5.70 (1.09)a,b 5.97 (0.97)b,c 6.17 (0.81)c Thoughts and feelings 5.07 (1.07)a 5.92 (1.02)b 5.61 (0.97)c 5.96 (0.85)b 5.35 (1.16)a,c Intensity of feelings 4.64 (1.39)a 5.25 (1.30)b 5.27 (1.44)b 5.30 (1.37)b 3.89 (1.55)c Timing 7.86 (1.77)a 7.86 (1.34)a 7.73 (1.66)a 7.51 (1.99)a 2.54 (1.16)b Positive affect 2.37 (0.92)a 3.06 (0.97)b 2.43 (0.77)a 2.99 (0.85)b 2.83 (0.84)b Negative affect 1.73 (0.82)a 1.25 (0.37)b 1.73 (0.79)a 1.31 (0.54)b 1.31 (0.54)b Bad–good 4.23 (1.69)a 5.65 (1.37)b 4.48 (1.64)a 5.85 (1.27)b 5.56 (1.29)b Sad–happy 4.12 (1.71)a 5.48 (1.57)b 4.17 (1.63)a 5.73 (1.28)b 5.46 (1.40)b Tense–relaxed 4.36 (1.84)a 5.42 (1.61)b 4.56 (1.66)a 5.79 (1.32)b 5.47 (1.57)b Negative–positive 4.32 (1.67)a 5.64 (1.40)b 4.37 (1.60)a 5.89 (1.30)b 5.53 (1.43)b Uncomfortable–comfortable 4.58 (1.77)a 5.60 (1.38)b 4.78 (1.71)a 5.91 (1.20)b 5.69 (1.39)b Distressed–satisfied 4.33 (1.71)a 5.57 (1.50)b 4.39 (1.53)a 5.60 (1.32)b 5.03 (1.61)b Time spent on writing (in seconds) 227.29 (137.43)a 271.24 (178.81)a,b 285.63 (178.55)b 256.94 (156.08)a,b 248.65 (159.09)a,b Number of words 107.46 (61.14)a 125.36 (75.31)a,b 134.09 (81.49)b 105.21 (59.70)a,c 112.79 (68.05)a,b Means not sharing subscripts within rows are significantly different at P < 0.05 based on Fisher’s least significant difference post hoc paired comparisons.
Measures Unethical-self Ethical-self Unethical-other Ethical-other Clarity 5.58 (1.19)a 6.07 (0.81)b 5.54 (1.11)a 5.55 (1.13)a Sensory 2.74 (1.38)a 3.57 (1.46)b 2.67 (1.29)a 2.80 (1.43)a Time context 5.66 (1.13)a 6.08 (0.91)b 5.44 (1.32)a,c 5.38 (1.51)a,b Spatial context 4.89 (1.75)a 5.49 (1.34)b 4.69 (1.61)a 5.21 (1.47)a Thoughts and feelings 5.49 (0.98)a 5.93 (0.84)b 5.38 (1.28)a 5.24 (1.21)a Intensity of feelings 5.02 (1.39)a 5.27 (1.36)a 5.02 (1.37)a 4.55 (1.39)b Timing 7.98 (1.73)a 7.73 (1.64)a 8.09 (1.37)a 7.00 (1.77)b Positive affect 2.37 (0.92)a 3.06 (0.97)b 2.59 (0.88)c 2.87 (0.80)b Negative affect 1.73 (0.82)a 1.25 (0.37)b,c 1.55 (0.73)b 1.32 (0.52)c Bad–good 3.84 (1.89)a 5.66 (1.43)b 4.68 (1.60)c 5.60 (1.32)b Sad–happy 3.66 (1.89)a 5.49 (1.56)b 4.29 (1.72)c 5.36 (1.57)b Tense–relaxed 4.13 (1.94)a 5.42 (1.60)b 4.59 (1.83)a 5.34 (1.69)b Negative–positive 3.87 (1.78)a 5.73 (1.40)b 4.34 (1.84)c 5.72 (1.47)b Uncomfortable–comfortable 3.93 (2.01)a 5.51 (1.49)b 4.72 (1.71)c 5.51 (1.52)b Distressed–satisfied 3.96 (1.86)a 5.38 (1.62)b 4.51 (1.67)c 5.34 (1.45)b Time spent on writing (in seconds) 368.35 (383.96)a 326.59 (334.81)a 337.20 (208.90)a 300.64 (235.87)a Number of words 143.13 (89.72)a 126.17 (76.29)a,b 135.13 (77.64)b 110.11 (74.42)b Means not sharing subscripts within rows are significantly different at the P < 0.05 based on Fisher’s least-significant difference post hoc paired comparisons.
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