Goats from the Zagros Mountains may represent the earliest examples of goat herding.
Image credit: The Central Zagros Project.
Edited by Stephen T. Warren, Emory University School of Medicine, Atlanta, GA, and approved April 15, 2016 (received for review January 7, 2016)
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- Published in issue May 31, 2016.
- Published online May 31, 2016.
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- Previous version (May 16, 2016 - 12:01).
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Author Information
- Emma L. Ivanssona,b,1,2,
- Kate Megquiera,b,
- Sergey V. Kozyreva,
- Eva Muréna,
- Izabella Baranowska Körbergc,3,
- Ross Swoffordb,
- Michele Koltookianb,
- Noriko Tonomurab,d,
- Rong Zenge,
- Ana L. Kolicheskie,
- Liz Hansene,
- Martin L. Katzf,
- Gayle C. Johnsone,
- Gary S. Johnsone,
- Joan R. Coatesg, and
- Kerstin Lindblad-Toha,b,1
- aScience for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden;
- bBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142;
- cDepartment of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden;
- dDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536;
- eDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211;
- fMason Eye Institute, School of Medicine, University of Missouri, Columbia, MO 65201;
- gDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211
Edited by Stephen T. Warren, Emory University School of Medicine, Atlanta, GA, and approved April 15, 2016 (received for review January 7, 2016)
Footnotes
- ↵1To whom correspondence may be addressed. Email: emma.ivansson{at}ki.se or kersli{at}broadinstitute.org.
↵2Present address: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
↵3Present address: Department of Women’s and Children’s Health, Karolinska Institutet, Karolinska University Hospital Solna, 171 76, Stockholm, Sweden.
Author contributions: E.L.I. and K.L.-T. designed research; E.L.I., K.M., S.V.K., E.M., I.B.K., R.S., M.K., N.T., R.Z., A.L.K., L.H., M.L.K., G.C.J., G.S.J., J.R.C., and K.L.-T. performed research; E.L.I., K.M., and S.V.K. analyzed data; and E.L.I. and K.M. wrote the paper.
Conflict of interest statement: A DNA test to identify dogs at risk of developing degenerative myelopathy is the subject of four awarded patents (European Patent 2247752, Australian Patent 2009212473, Japanese Patent 5584916, and Mexico Patent 326951) and one pending patent application (Canada Patent 2,714,393). Three of the coauthors (G.S.J., J.R.C., and K.L.-T.) are co-inventors listed on these patents and patent applications. A patent application was filed as to certain subject matter of this manuscript.
This article is a PNAS Direct Submission.
Data deposition: The National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) www.ncbi.nlm.nih.gov/geo accession numbers for the genome-wide association data presented in this paper are GSE80735 (PWC) and GSE80315 (Boxer). The NCBI Single Nucleotide Polymorphism Database (dbSNP) accession numbers for the Illumina MiSeq-detected variants reported in this paper are 1987230493–1987230525. The NCBI Sequence Read Archive (SRA) accession numbers for the whole-genome sequences of three PWCs reported in this paper are SRX745862–SRX745864. The GenBank accession numbers for the canine SP110 alternative transcripts reported in this paper are KP245899–KP245902.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1600084113/-/DCSupplemental.
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