Table of Contents

Biological Sciences

• Anthropology

  • Open Access

    The integration of quantitative genetics, paleontology, and neontology reveals genetic underpinnings of primate dental evolution

    • From the Cover

    Leslea J. Hlusko, Christopher A. Schmitt, Tesla A. Monson, Marianne F. Brasil, and Michael C. Mahaney

    PNAS August 16, 2016 113 (33) 9262-9267; first published July 11, 2016. https://doi.org/10.1073/pnas.1605901113

    See companion article:

    • Quantitative genetics for paleontological studies

      - Aug 05, 2016

• Applied Biological Sciences

  • Open Access

    Cytochrome P450 associated with insecticide resistance catalyzes cuticular hydrocarbon production in Anopheles gambiae

    • From the Cover

    Vasileia Balabanidou, Anastasia Kampouraki, Marina MacLean, Gary J. Blomquist, Claus Tittiger, M. Patricia Juárez, Sergio J. Mijailovsky, George Chalepakis, Amalia Anthousi, Amy Lynd, Sanou Antoine, Janet Hemingway, Hilary Ranson, Gareth J. Lycett, and John Vontas

    PNAS August 16, 2016 113 (33) 9268-9273; first published July 20, 2016. https://doi.org/10.1073/pnas.1608295113

    See companion article:

    • Mosquitoes boost body armor

      - Aug 05, 2016

• Biochemistry

  • You have access

    Innate immunity kinase TAK1 phosphorylates Rab1 on a hotspot for posttranslational modifications by host and pathogen

    Rebecca S. Levin, Nicholas T. Hertz, Alma L. Burlingame, Kevan M. Shokat, and Shaeri Mukherjee

    PNAS August 16, 2016 113 (33) E4776-E4783; first published August 1, 2016. https://doi.org/10.1073/pnas.1608355113
  • You have access

    Distinct cellular properties of oncogenic KIT receptor tyrosine kinase mutants enable alternative courses of cancer cell inhibition

    Xiarong Shi, Leiliane P. Sousa, Elizabeth M. Mandel-Bausch, Francisco Tome, Andrey V. Reshetnyak, Yaron Hadari, Joseph Schlessinger, and Irit Lax

    PNAS August 16, 2016 113 (33) E4784-E4793; first published August 1, 2016. https://doi.org/10.1073/pnas.1610179113
  • You have access

    Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

    Zhe Li Salie, Karen A. Kirby, Eleftherios Michailidis, Bruno Marchand, Kamalendra Singh, Lisa C. Rohan, Eiichi N. Kodama, Hiroaki Mitsuya, Michael A. Parniak, and Stefan G. Sarafianos

    PNAS August 16, 2016 113 (33) 9274-9279; first published August 3, 2016. https://doi.org/10.1073/pnas.1605223113
  • Open Access

    Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of α-dystroglycan

    Naoyuki Kuwabara, Hiroshi Manya, Takeyuki Yamada, Hiroaki Tateno, Motoi Kanagawa, Kazuhiro Kobayashi, Keiko Akasaka-Manya, Yuriko Hirose, Mamoru Mizuno, Mitsunori Ikeguchi, Tatsushi Toda, Jun Hirabayashi, Toshiya Senda, Tamao Endo, and Ryuichi Kato

    PNAS August 16, 2016 113 (33) 9280-9285; first published August 4, 2016. https://doi.org/10.1073/pnas.1525545113

• Biophysics and Computational Biology

  • You have access

    Dynamic periplasmic chaperone reservoir facilitates biogenesis of outer membrane proteins

    Shawn M. Costello, Ashlee M. Plummer, Patrick J. Fleming, and Karen G. Fleming

    PNAS August 16, 2016 113 (33) E4794-E4800; first published August 1, 2016. https://doi.org/10.1073/pnas.1601002113
  • You have access

    Structure of fully protonated proteins by proton-detected magic-angle spinning NMR

    Loren B. Andreas, Kristaps Jaudzems, Jan Stanek, Daniela Lalli, Andrea Bertarello, Tanguy Le Marchand, Diane Cala-De Paepe, Svetlana Kotelovica, Inara Akopjana, Benno Knott, Sebastian Wegner, Frank Engelke, Anne Lesage, Lyndon Emsley, Kaspars Tars, Torsten Herrmann, and Guido Pintacuda

    PNAS August 16, 2016 113 (33) 9187-9192; first published August 3, 2016. https://doi.org/10.1073/pnas.1602248113
  • You have access

    Transition path theory analysis of c-Src kinase activation

    Yilin Meng, Diwakar Shukla, Vijay S. Pande, and Benoît Roux

    PNAS August 16, 2016 113 (33) 9193-9198; first published August 1, 2016. https://doi.org/10.1073/pnas.1602790113
  • You have access

    Partial squeeze film levitation modulates fingertip friction

    Michaël Wiertlewski, Rebecca Fenton Friesen, and J. Edward Colgate

    PNAS August 16, 2016 113 (33) 9210-9215; first published August 1, 2016. https://doi.org/10.1073/pnas.1603908113

    See companion article:

    • Squeeze film levitation of human fingertip

      - Nov 01, 2016
  • Open Access

    Spatial organization of bacterial transcription and translation

    Michele Castellana, Sophia Hsin-Jung Li, and Ned S. Wingreen

    PNAS August 16, 2016 113 (33) 9286-9291; first published August 2, 2016. https://doi.org/10.1073/pnas.1604995113

• Cell Biology

  • You have access

    Gambogic acid identifies an isoform-specific druggable pocket in the middle domain of Hsp90β

    Kendrick H. Yim, Thomas L. Prince, Shiwei Qu, Fang Bai, Patricia A. Jennings, José N. Onuchic, Emmanuel A. Theodorakis, and Leonard Neckers

    PNAS August 16, 2016 113 (33) E4801-E4809; first published July 27, 2016. https://doi.org/10.1073/pnas.1606655113
  • You have access

    Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers

    Benoit Miotto, Zhe Ji, and Kevin Struhl

    PNAS August 16, 2016 113 (33) E4810-E4819; first published July 19, 2016. https://doi.org/10.1073/pnas.1609060113

    See companion article:

    • ORChestrating the human DNA replication program

      - Aug 05, 2016
  • You have access

    Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis

    • From the Cover

    Ramray Bhat, Brian Belardi, Hidetoshi Mori, Peiwen Kuo, Andrew Tam, William C. Hines, Quynh-Thu Le, Carolyn R. Bertozzi, and Mina J. Bissell

    PNAS August 16, 2016 113 (33) E4820-E4827; first published August 5, 2016. https://doi.org/10.1073/pnas.1609135113
  • You have access

    Intratumoral oxygen gradients mediate sarcoma cell invasion

    Daniel M. Lewis, Kyung Min Park, Vitor Tang, Yu Xu, Koreana Pak, T. S. Karin Eisinger-Mathason, M. Celeste Simon, and Sharon Gerecht

    PNAS August 16, 2016 113 (33) 9292-9297; first published August 2, 2016. https://doi.org/10.1073/pnas.1605317113
  • Open Access

    Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury

    Pia Rantakari, Daniel A. Patten, Joona Valtonen, Marika Karikoski, Heidi Gerke, Harriet Dawes, Juha Laurila, Steffen Ohlmeier, Kati Elima, Stefan G. Hübscher, Chris J. Weston, Sirpa Jalkanen, David H. Adams, Marko Salmi, and Shishir Shetty

    PNAS August 16, 2016 113 (33) 9298-9303; first published July 29, 2016. https://doi.org/10.1073/pnas.1604780113
  • Open Access

    Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

    Igor Cervenka, Jana Valnohova, Ondrej Bernatik, Jakub Harnos, Matej Radsetoulal, Katerina Sedova, Katerina Hanakova, David Potesil, Miroslava Sedlackova, Alena Salasova, Zachary Steinhart, Stephane Angers, Gunnar Schulte, Ales Hampl, Zbynek Zdrahal, and Vitezslav Bryja

    PNAS August 16, 2016 113 (33) 9304-9309; first published August 2, 2016. https://doi.org/10.1073/pnas.1608783113

• Developmental Biology

  • You have access

    microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti

    Yang Zhang, Bo Zhao, Sourav Roy, Tusar T. Saha, Vladimir A. Kokoza, Ming Li, and Alexander S. Raikhel

    PNAS August 16, 2016 113 (33) E4828-E4836; first published August 3, 2016. https://doi.org/10.1073/pnas.1609792113

• Ecology

  • Open Access

    Timing and causes of mid-Holocene mammoth extinction on St. Paul Island, Alaska

    • Cozzarelli Prize Winner

    Russell W. Graham, Soumaya Belmecheri, Kyungcheol Choy, Brendan J. Culleton, Lauren J. Davies, Duane Froese, Peter D. Heintzman, Carrie Hritz, Joshua D. Kapp, Lee A. Newsom, Ruth Rawcliffe, Émilie Saulnier-Talbot, Beth Shapiro, Yue Wang, John W. Williams, and Matthew J. Wooller

    PNAS August 16, 2016 113 (33) 9310-9314; first published August 1, 2016. https://doi.org/10.1073/pnas.1604903113

• Evolution

  • You have access

    Rapid adaptation of harmful cyanobacteria to rising CO₂

    Giovanni Sandrini, Xing Ji, Jolanda M. H. Verspagen, Robert P. Tann, Pieter C. Slot, Veerle M. Luimstra, J. Merijn Schuurmans, Hans C. P. Matthijs, and Jef Huisman

    PNAS August 16, 2016 113 (33) 9315-9320; first published August 1, 2016. https://doi.org/10.1073/pnas.1602435113

• Immunology and Inflammation

  • You have access

    Regulation of eosinophilia and allergic airway inflammation by the glycan-binding protein galectin-1

    • From the Cover

    Xiao Na Ge, Sung Gil Ha, Yana G. Greenberg, Amrita Rao, Idil Bastan, Ada G. Blidner, Savita P. Rao, Gabriel A. Rabinovich, and P. Sriramarao

    PNAS August 16, 2016 113 (33) E4837-E4846; first published July 25, 2016. https://doi.org/10.1073/pnas.1601958113

    See companion article:

    • Eosinophils, galectins, and a reason to breathe

      - Aug 05, 2016
  • You have access

    CCN1/CYR61-mediated meticulous patrolling by Ly6C^low monocytes fuels vascular inflammation

    Beat A. Imhof, Stephane Jemelin, Romain Ballet, Christian Vesin, Marc Schapira, Melis Karaca, and Yalin Emre

    PNAS August 16, 2016 113 (33) E4847-E4856; first published August 1, 2016. https://doi.org/10.1073/pnas.1607710113
  • You have access

    Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

    Wenqing Gao, Jieling Yang, Wang Liu, Yupeng Wang, and Feng Shao

    PNAS August 16, 2016 113 (33) E4857-E4866; first published August 1, 2016. https://doi.org/10.1073/pnas.1601700113
  • You have access

    Engagement of SLAMF3 enhances CD4⁺ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus

    Denis Comte, Maria P. Karampetsou, Katalin Kis-Toth, Nobuya Yoshida, Sean J. Bradley, Masayuki Mizui, Michihito Kono, Julie R. Solomon, Vasileios C. Kyttaris, and George C. Tsokos

    PNAS August 16, 2016 113 (33) 9321-9326; first published August 1, 2016. https://doi.org/10.1073/pnas.1605081113

• Medical Sciences

  • You have access

    Menopause accelerates biological aging

    Morgan E. Levine, Ake T. Lu, Brian H. Chen, Dena G. Hernandez, Andrew B. Singleton, Luigi Ferrucci, Stefania Bandinelli, Elias Salfati, JoAnn E. Manson, Austin Quach, Cynthia D. J. Kusters, Diana Kuh, Andrew Wong, Andrew E. Teschendorff, Martin Widschwendter, Beate R. Ritz, Devin Absher, Themistocles L. Assimes, and Steve Horvath

    PNAS August 16, 2016 113 (33) 9327-9332; first published July 25, 2016. https://doi.org/10.1073/pnas.1604558113
  • You have access

    O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis

    Qinghua Zeng, Rui-Xun Zhao, Jianfeng Chen, Yining Li, Xiang-Dong Li, Xiao-Long Liu, Wei-Ming Zhang, Cheng-Shi Quan, Yi-Shu Wang, Ying-Xian Zhai, Jian-Wei Wang, Mariam Youssef, Rutao Cui, Jiyong Liang, Nicholas Genovese, Louise T. Chow, Yu-Lin Li, and Zhi-Xiang Xu

    PNAS August 16, 2016 113 (33) 9333-9338; first published August 1, 2016. https://doi.org/10.1073/pnas.1606801113
  • You have access

    Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer

    Yi Qu, Naouel Gharbi, Xing Yuan, Jan Roger Olsen, Pernille Blicher, Bjørn Dalhus, Karl A. Brokstad, Biaoyang Lin, Anne Margrete Øyan, Weidong Zhang, Karl-Henning Kalland, and Xisong Ke

    PNAS August 16, 2016 113 (33) 9339-9344; first published August 1, 2016. https://doi.org/10.1073/pnas.1604520113

• Microbiology

  • You have access

    The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus

    Rachel D. Hood, Sean A. Higgins, Avi Flamholz, Robert J. Nichols, and David F. Savage

    PNAS August 16, 2016 113 (33) E4867-E4876; first published August 2, 2016. https://doi.org/10.1073/pnas.1524915113
  • You have access

    Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells

    • Inaugural Article

    Brandon Lyon Jutras, Molly Scott, Bradley Parry, Jacob Biboy, Joe Gray, Waldemar Vollmer, and Christine Jacobs-Wagner

    PNAS August 16, 2016 113 (33) 9162-9170; first published August 9, 2016. https://doi.org/10.1073/pnas.1610805113

    See companion article:

    • QnAs with Christine Jacobs-Wagner

      - Aug 09, 2016
  • You have access

    Early gut colonizers shape parasite susceptibility and microbiota composition in honey bee workers

    Ryan S. Schwarz, Nancy A. Moran, and Jay D. Evans

    PNAS August 16, 2016 113 (33) 9345-9350; first published August 1, 2016. https://doi.org/10.1073/pnas.1606631113
  • Open Access

    Structure and genome release of Twort-like Myoviridae phage with a double-layered baseplate

    Jiří Nováček, Marta Šiborová, Martin Benešík, Roman Pantůček, Jiří Doškař, and Pavel Plevka

    PNAS August 16, 2016 113 (33) 9351-9356; first published July 28, 2016. https://doi.org/10.1073/pnas.1605883113

• Neuroscience

  • You have access

    Learning to soar in turbulent environments

    Gautam Reddy, Antonio Celani, Terrence J. Sejnowski, and Massimo Vergassola

    PNAS August 16, 2016 113 (33) E4877-E4884; first published August 1, 2016. https://doi.org/10.1073/pnas.1606075113
  • Open Access

    Neural mechanisms of transient neocortical beta rhythms: Converging evidence from humans, computational modeling, monkeys, and mice

    Maxwell A. Sherman, Shane Lee, Robert Law, Saskia Haegens, Catherine A. Thorn, Matti S. Hämäläinen, Christopher I. Moore, and Stephanie R. Jones

    PNAS August 16, 2016 113 (33) E4885-E4894; first published July 28, 2016. https://doi.org/10.1073/pnas.1604135113
  • You have access

    Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death

    Isamu Aiba, Xander H. T. Wehrens, and Jeffrey L. Noebels

    PNAS August 16, 2016 113 (33) E4895-E4903; first published August 1, 2016. https://doi.org/10.1073/pnas.1605216113
  • You have access

    Pacemaker-neuron–dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

    Euna Lee, Eunjoo Cho, Doo Hyun Kang, Eun Hee Jeong, Zheng Chen, Seung-Hee Yoo, and Eun Young Kim

    PNAS August 16, 2016 113 (33) E4904-E4913; first published August 3, 2016. https://doi.org/10.1073/pnas.1523494113
  • You have access

    Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory

    Carolina Garrido Zinn, Nicolas Clairis, Lorena Evelyn Silva Cavalcante, Cristiane Regina Guerino Furini, Jociane de Carvalho Myskiw, and Ivan Izquierdo

    PNAS August 16, 2016 113 (33) E4914-E4919; first published August 1, 2016. https://doi.org/10.1073/pnas.1609883113
  • You have access

    Extensive phosphorylation of AMPA receptors in neurons

    Graham H. Diering, Seok Heo, Natasha K. Hussain, Bian Liu, and Richard L. Huganir

    PNAS August 16, 2016 113 (33) E4920-E4927; first published August 1, 2016. https://doi.org/10.1073/pnas.1610631113
  • You have access

    Neurodevelopmental origins of lifespan changes in brain and cognition

    • From the Cover

    Kristine B. Walhovd, Stine K. Krogsrud, Inge K. Amlien, Hauke Bartsch, Atle Bjørnerud, Paulina Due-Tønnessen, Håkon Grydeland, Donald J. Hagler Jr., Asta K. Håberg, William S. Kremen, Lia Ferschmann, Lars Nyberg, Matthew S. Panizzon, Darius A. Rohani, Jon Skranes, Andreas B. Storsve, Anne Elisabeth Sølsnes, Christian K. Tamnes, Wesley K. Thompson, Chase Reuter, Anders M. Dale, and Anders M. Fjell

    PNAS August 16, 2016 113 (33) 9357-9362; first published July 18, 2016. https://doi.org/10.1073/pnas.1524259113

    See companion article:

    • Early life and aging

      - Jul 19, 2016
  • You have access

    High-frequency oscillations in human and monkey neocortex during the wake–sleep cycle

    Michel Le Van Quyen, Lyle E. Muller II, Bartosz Telenczuk, Eric Halgren, Sydney Cash, Nicholas G. Hatsopoulos, Nima Dehghani, and Alain Destexhe

    PNAS August 16, 2016 113 (33) 9363-9368; first published August 1, 2016. https://doi.org/10.1073/pnas.1523583113

• Plant Biology

  • Open Access

    Physical coupling of activation and derepression activities to maintain an active transcriptional state at FLC

    Hongchun Yang, Martin Howard, and Caroline Dean

    PNAS August 16, 2016 113 (33) 9369-9374; first published August 1, 2016. https://doi.org/10.1073/pnas.1605733113
  • You have access

    FAR-RED ELONGATED HYPOCOTYL3 activates SEPALLATA2 but inhibits CLAVATA3 to regulate meristem determinacy and maintenance in Arabidopsis

    Dongming Li, Xing Fu, Lin Guo, Zhigang Huang, Yongpeng Li, Yang Liu, Zishan He, Xiuwei Cao, Xiaohan Ma, Meicheng Zhao, Guohui Zhu, Langtao Xiao, Haiyang Wang, Xuemei Chen, Renyi Liu, and Xigang Liu

    PNAS August 16, 2016 113 (33) 9375-9380; first published July 28, 2016. https://doi.org/10.1073/pnas.1602960113