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Edited by Ronald W. Davis, Stanford University School of Medicine, Stanford, CA, and approved July 13, 2016 (received for review May 11, 2016)
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History:
- Published in issue September 13, 2016.
- Published first August 29, 2016.
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Freely available online through the PNAS open access option.
Author Information
- Robert K. Naviauxa,b,c,d,1,
- Jane C. Naviauxa,e,
- Kefeng Lia,b,
- A. Taylor Brighta,b,
- William A. Alaynicka,b,
- Lin Wanga,b,
- Asha Baxterf,
- Neil Nathanf,2,
- Wayne Andersonf, and
- Eric Gordonf
- aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- cDepartment of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- dDepartment of Pathology, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- eDepartment of Neurosciences, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- fGordon Medical Associates, Santa Rosa, CA 95403
Edited by Ronald W. Davis, Stanford University School of Medicine, Stanford, CA, and approved July 13, 2016 (received for review May 11, 2016)
Footnotes
- ↵1To whom correspondence should be addressed. Email: rnaviaux{at}ucsd.edu.
↵2Present address: Redwood Valley Clinic, 8501 West Road, Redwood Valley, CA, 95470.
Author contributions: R.K.N., N.N., W.A., and E.G. designed research; R.K.N., J.C.N., K.L., A.T.B., L.W., A.B., N.N., W.A., and E.G. performed research; R.K.N., J.C.N., K.L., A.T.B., W.A.A., and L.W. contributed new reagents/analytic tools; R.K.N. wrote and managed the human subjects protocol; J.C.N. recruited subjects and developed methods; K.L. developed methods; A.T.B. created the pathway database and developed new bioinformatic methods; W.A.A. prepared the Cytoscape pathway visualizations; A.B. coordinated patient recruitment, medical histories, and clinical data; N.N., W.A., and E.G. identified and recruited patients; R.K.N., J.C.N., K.L., A.T.B., N.N., and E.G. analyzed data; and R.K.N., J.C.N., K.L., A.T.B., and W.A.A. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
Data deposition: The data reported in this paper have been deposited in the NIH Metabolomics Data Repository and Coordinating Center (DRCC) (accession no. ST000450).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1607571113/-/DCSupplemental.
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