Researchers are exploring whether these ubiquitous fluorinated molecules might worsen infections or hamper vaccine effectiveness.
Image credit: Shutterstock/Dmitry Naumov.
Research Article
Metabolic features of chronic fatigue syndrome
Robert K. Naviaux, Jane C. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, and Eric Gordon
- aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- cDepartment of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- dDepartment of Pathology, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- eDepartment of Neurosciences, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- fGordon Medical Associates, Santa Rosa, CA 95403
See allHide authors and affiliations
PNAS September 13, 2016 113 (37) E5472-E5480; first published August 29, 2016; https://doi.org/10.1073/pnas.1607571113
Robert K. Naviaux
aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
cDepartment of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
dDepartment of Pathology, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
Jane C. Naviaux
aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
eDepartment of Neurosciences, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
Kefeng Li
aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
A. Taylor Bright
aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
William A. Alaynick
aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
Lin Wang
aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
Asha Baxter
fGordon Medical Associates, Santa Rosa, CA 95403
Neil Nathan
fGordon Medical Associates, Santa Rosa, CA 95403
Wayne Anderson
fGordon Medical Associates, Santa Rosa, CA 95403
Eric Gordon
fGordon Medical Associates, Santa Rosa, CA 95403
Edited by Ronald W. Davis, Stanford University School of Medicine, Stanford, CA, and approved July 13, 2016 (received for review May 11, 2016)
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Article Information
vol. 113 no. 37 E5472-E5480
PubMed:
Published By:
Print ISSN:
Online ISSN:
History:
- Published in issue September 13, 2016.
- Published first August 29, 2016.
Copyright & Usage:
Freely available online through the PNAS open access option.
Author Information
- Robert K. Naviauxa,b,c,d,1,
- Jane C. Naviauxa,e,
- Kefeng Lia,b,
- A. Taylor Brighta,b,
- William A. Alaynicka,b,
- Lin Wanga,b,
- Asha Baxterf,
- Neil Nathanf,2,
- Wayne Andersonf, and
- Eric Gordonf
- aThe Mitochondrial and Metabolic Disease Center, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- bDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- cDepartment of Pediatrics, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- dDepartment of Pathology, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- eDepartment of Neurosciences, University of California, San Diego School of Medicine, San Diego, CA 92103-8467;
- fGordon Medical Associates, Santa Rosa, CA 95403
Edited by Ronald W. Davis, Stanford University School of Medicine, Stanford, CA, and approved July 13, 2016 (received for review May 11, 2016)
Footnotes
- ↵1To whom correspondence should be addressed. Email: rnaviaux{at}ucsd.edu.
↵2Present address: Redwood Valley Clinic, 8501 West Road, Redwood Valley, CA, 95470.
Author contributions: R.K.N., N.N., W.A., and E.G. designed research; R.K.N., J.C.N., K.L., A.T.B., L.W., A.B., N.N., W.A., and E.G. performed research; R.K.N., J.C.N., K.L., A.T.B., W.A.A., and L.W. contributed new reagents/analytic tools; R.K.N. wrote and managed the human subjects protocol; J.C.N. recruited subjects and developed methods; K.L. developed methods; A.T.B. created the pathway database and developed new bioinformatic methods; W.A.A. prepared the Cytoscape pathway visualizations; A.B. coordinated patient recruitment, medical histories, and clinical data; N.N., W.A., and E.G. identified and recruited patients; R.K.N., J.C.N., K.L., A.T.B., N.N., and E.G. analyzed data; and R.K.N., J.C.N., K.L., A.T.B., and W.A.A. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
Data deposition: The data reported in this paper have been deposited in the NIH Metabolomics Data Repository and Coordinating Center (DRCC) (accession no. ST000450).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1607571113/-/DCSupplemental.
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Metabolic features of chronic fatigue syndrome
Robert K. Naviaux, Jane C. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, Eric Gordon
Proceedings of the National Academy of Sciences Sep 2016, 113 (37) E5472-E5480; DOI: 10.1073/pnas.1607571113
Citation Manager Formats
Metabolic features of chronic fatigue syndrome
Robert K. Naviaux, Jane C. Naviaux, Kefeng Li, A. Taylor Bright, William A. Alaynick, Lin Wang, Asha Baxter, Neil Nathan, Wayne Anderson, Eric Gordon
Proceedings of the National Academy of Sciences Sep 2016, 113 (37) E5472-E5480; DOI: 10.1073/pnas.1607571113
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- Biological Sciences
- Medical Sciences
This article has Letters. Please see:
- Relationship between Research Article and Letter - November 03, 2016
- Relationship between Research Article and Letter - January 26, 2017
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- Metabolomics and chronic fatigue syndrome- Nov 03, 2016
- Metabolome of chronic fatigue syndrome- Jan 26, 2017
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