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Research Article

Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia

Norman E. Taylor, Christa J. Van Dort, Jonathan D. Kenny, JunZhu Pei, Jennifer A. Guidera, Ksenia Y. Vlasov, Justin T. Lee, Edward S. Boyden, Emery N. Brown, and Ken Solt
  1. aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
  2. bDepartment of Anaesthesia, Harvard Medical School, Boston, MA 02114;
  3. cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
  4. dMedia Lab, Massachusetts Institute of Technology, Cambridge, MA 02139;
  5. eMcGovern Institute, Massachusetts Institute of Technology, Cambridge, MA 02139;
  6. fDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;
  7. gThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;
  8. hInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139

See allHide authors and affiliations

PNAS November 8, 2016 113 (45) 12826-12831; first published October 24, 2016; https://doi.org/10.1073/pnas.1614340113
Norman E. Taylor
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
bDepartment of Anaesthesia, Harvard Medical School, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Christa J. Van Dort
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
bDepartment of Anaesthesia, Harvard Medical School, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Jonathan D. Kenny
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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JunZhu Pei
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Jennifer A. Guidera
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Ksenia Y. Vlasov
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Justin T. Lee
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Edward S. Boyden
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
dMedia Lab, Massachusetts Institute of Technology, Cambridge, MA 02139;
eMcGovern Institute, Massachusetts Institute of Technology, Cambridge, MA 02139;
fDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;
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Emery N. Brown
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
bDepartment of Anaesthesia, Harvard Medical School, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
gThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;
hInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139
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  • For correspondence: enb@neurostat.mit.edu
Ken Solt
aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
bDepartment of Anaesthesia, Harvard Medical School, Boston, MA 02114;
cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
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  1. Contributed by Emery N. Brown, September 14, 2016 (sent for review February 29, 2016; reviewed by Loren M. Frank, Robert W. Gereau, and Andrew Jenkins)

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Article Information

vol. 113 no. 45 12826-12831
DOI: 
https://doi.org/10.1073/pnas.1614340113
PubMed: 
27791160

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue November 8, 2016.
  • Published first October 24, 2016.

Copyright & Usage: 

Author Information

  1. Norman E. Taylora,b,c,
  2. Christa J. Van Dorta,b,c,
  3. Jonathan D. Kennya,c,
  4. JunZhu Peia,c,
  5. Jennifer A. Guideraa,c,
  6. Ksenia Y. Vlasova,c,
  7. Justin T. Leea,c,
  8. Edward S. Boydenc,d,e,f,
  9. Emery N. Browna,b,c,g,h,1,2, and
  10. Ken Solta,b,c,1
  1. aDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114;
  2. bDepartment of Anaesthesia, Harvard Medical School, Boston, MA 02114;
  3. cDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139;
  4. dMedia Lab, Massachusetts Institute of Technology, Cambridge, MA 02139;
  5. eMcGovern Institute, Massachusetts Institute of Technology, Cambridge, MA 02139;
  6. fDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139;
  7. gThe Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139;
  8. hInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139
  1. Contributed by Emery N. Brown, September 14, 2016 (sent for review February 29, 2016; reviewed by Loren M. Frank, Robert W. Gereau, and Andrew Jenkins)

Footnotes

  • ↵1E.N.B. and K.S. contributed equally to this work.

  • ↵2To whom correspondence should be addressed. Email: enb{at}neurostat.mit.edu.
  • Author contributions: N.E.T., C.J.V.D., E.N.B., and K.S. designed research; N.E.T. performed research; C.J.V.D., E.S.B., and E.N.B. contributed new reagents/analytic tools; N.E.T., J.D.K., J.P., J.A.G., K.Y.V., J.T.L., E.N.B., and K.S. analyzed data; and N.E.T. and K.S. wrote the paper.

  • Reviewers: L.M.F., Howard Hughes Medical Institute; R.W.G., Washington University; and A.J., Emory University School of Medicine.

  • The authors declare no conflict of interest.

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Article usage

Article usage: October 2016 to March 2021

AbstractFullPdf
Oct 20163635130217
Nov 20164892368417
Dec 201653191112
Total 20169058589746
Jan 20173907576
Feb 20173686371
Mar 20172374039
Apr 20171703437
May 20171673687
Jun 201713449107
Jul 20171855489
Aug 20171516350
Sep 201714510352
Oct 20171047440
Nov 20171245139
Dec 2017864415
Total 20172261686702
Jan 2018786132
Feb 201818010036
Mar 201821613144
Apr 201810912637
May 201812713835
Jun 201810310118
Jul 2018878115
Aug 201811512440
Sep 201810710111
Oct 20182614631
Nov 2018926038
Dec 20181511727
Total 201811721486364
Jan 2019146826
Feb 2019117527
Mar 2019188331
Apr 20192611039
May 2019228542
Jun 2019189833
Jul 2019227433
Aug 2019107131
Sep 2019126624
Oct 2019238924
Nov 2019146625
Dec 2019147330
Total 2019204958365
Jan 2020178221
Feb 20202812443
Mar 2020196922
Apr 2020255861
May 20202511847
Jun 2020219861
Jul 2020159233
Aug 2020247940
Sep 20201811550
Oct 20202913357
Nov 20204014751
Dec 2020328245
Total 20202931197531
Jan 20212911044
Feb 2021167342
Mar 20211105
Total 20214619391
Total1303451092799
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Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia
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VTA dopamine neuron activation reverses anesthesia
Norman E. Taylor, Christa J. Van Dort, Jonathan D. Kenny, JunZhu Pei, Jennifer A. Guidera, Ksenia Y. Vlasov, Justin T. Lee, Edward S. Boyden, Emery N. Brown, Ken Solt
Proceedings of the National Academy of Sciences Nov 2016, 113 (45) 12826-12831; DOI: 10.1073/pnas.1614340113

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VTA dopamine neuron activation reverses anesthesia
Norman E. Taylor, Christa J. Van Dort, Jonathan D. Kenny, JunZhu Pei, Jennifer A. Guidera, Ksenia Y. Vlasov, Justin T. Lee, Edward S. Boyden, Emery N. Brown, Ken Solt
Proceedings of the National Academy of Sciences Nov 2016, 113 (45) 12826-12831; DOI: 10.1073/pnas.1614340113
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Proceedings of the National Academy of Sciences: 113 (45)
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