Proceedings of the National Academy of Sciences: 113 (47)

Applied Mathematics
- Open Access
  A variational perspective on accelerated methods in optimization
  Andre Wibisono, Ashia C. Wilson, and Michael I. Jordan
  
  PNAS November 22, 2016 113 (47) E7351-E7358; first published November 9, 2016. https://doi.org/10.1073/pnas.1614734113
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  Supercritical entanglement in local systems: Counterexample to the area law for quantum matter
  Ramis Movassagh and Peter W. Shor
  
  PNAS November 22, 2016 113 (47) 13278-13282; first published November 7, 2016. https://doi.org/10.1073/pnas.1605716113
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  Optimal prediction of the number of unseen species
  Alon Orlitsky, Ananda Theertha Suresh, and Yihong Wu
  
  PNAS November 22, 2016 113 (47) 13283-13288; first published November 8, 2016. https://doi.org/10.1073/pnas.1607774113
Applied Physical Sciences
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  Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)
  Fabrice Gielen, Raphaelle Hours, Stephane Emond, Martin Fischlechner, Ursula Schell, and Florian Hollfelder
  
  PNAS November 22, 2016 113 (47) E7383-E7389; first published November 7, 2016. https://doi.org/10.1073/pnas.1606927113
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  Red cells’ dynamic morphologies govern blood shear thinning under microcirculatory flow conditions
  Luca Lanotte, Johannes Mauer, Simon Mendez, Dmitry A. Fedosov, Jean-Marc Fromental, Viviana Claveria, Franck Nicoud, Gerhard Gompper, and Manouk Abkarian
  
  PNAS November 22, 2016 113 (47) 13289-13294; first published November 9, 2016. https://doi.org/10.1073/pnas.1608074113
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  Hydrogel films and coatings by swelling-induced gelation
  David Moreau, Caroline Chauvet, François Etienne, François P. Rannou, and Laurent Corté
  
  PNAS November 22, 2016 113 (47) 13295-13300; first published November 7, 2016. https://doi.org/10.1073/pnas.1609603113
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  Accelerated search for BaTiO₃-based piezoelectrics with vertical morphotropic phase boundary using Bayesian learning
  Dezhen Xue, Prasanna V. Balachandran, Ruihao Yuan, Tao Hu, Xiaoning Qian, Edward R. Dougherty, and Turab Lookman
  
  PNAS November 22, 2016 113 (47) 13301-13306; first published November 7, 2016. https://doi.org/10.1073/pnas.1607412113
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  Superhydrophobicity enhancement through substrate flexibility
  Thomas Vasileiou, Julia Gerber, Jana Prautzsch, Thomas M. Schutzius, and Dimos Poulikakos
  
  PNAS November 22, 2016 113 (47) 13307-13312; first published November 9, 2016. https://doi.org/10.1073/pnas.1611631113
Chemistry
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  Mastering the interface for advanced all-solid-state lithium rechargeable batteries
  Yutao Li, Weidong Zhou, Xi Chen, Xujie Lü, Zhiming Cui, Sen Xin, Leigang Xue, Quanxi Jia, and John B. Goodenough
  
  PNAS November 22, 2016 113 (47) 13313-13317; first published November 7, 2016. https://doi.org/10.1073/pnas.1615912113
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  One low-dose exposure of gold nanoparticles induces long-term changes in human cells
  Priscila Falagan-Lotsch, Elissa M. Grzincic, and Catherine J. Murphy
  
  PNAS November 22, 2016 113 (47) 13318-13323; first published November 7, 2016. https://doi.org/10.1073/pnas.1616400113
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  In situ solid-state electrochemistry of mass-selected ions at well-defined electrode–electrolyte interfaces
  Venkateshkumar Prabhakaran, Grant E. Johnson, Bingbing Wang, and Julia Laskin
  
  PNAS November 22, 2016 113 (47) 13324-13329; first published November 7, 2016. https://doi.org/10.1073/pnas.1608730113
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  Siderophore-based immunization strategy to inhibit growth of enteric pathogens
  Martina Sassone-Corsi, Phoom Chairatana, Tengfei Zheng, Araceli Perez-Lopez, Robert A. Edwards, Michael D. George, Elizabeth M. Nolan, and Manuela Raffatellu
  
  PNAS November 22, 2016 113 (47) 13462-13467; first published November 7, 2016. https://doi.org/10.1073/pnas.1606290113
  
  See companion article:
  Siderophore vaccine protects against UTI
  - Nov 07, 2016
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  Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection
  Laura A. Mike, Sara N. Smith, Christopher A. Sumner, Kathryn A. Eaton, and Harry L. T. Mobley
  
  PNAS November 22, 2016 113 (47) 13468-13473; first published November 7, 2016. https://doi.org/10.1073/pnas.1606324113
  
  See companion article:
  Siderophore-based immunization inhibits pathogens
  - Nov 07, 2016
Earth, Atmospheric, and Planetary Sciences
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  Rapid conversion of an oceanic spreading center to a subduction zone inferred from high-precision geochronology
  Timothy E. Keenan, John Encarnación, Robert Buchwaldt, Dan Fernandez, James Mattinson, Christine Rasoazanamparany, and P. Benjamin Luetkemeyer
  
  PNAS November 22, 2016 113 (47) E7359-E7366; first published November 7, 2016. https://doi.org/10.1073/pnas.1609999113
- Open Access
  Radiocarbon dating of seized ivory confirms rapid decline in African elephant populations and provides insight into illegal trade
  From the Cover
  
  Thure E. Cerling, Janet E. Barnette, Lesley A. Chesson, Iain Douglas-Hamilton, Kathleen S. Gobush, Kevin T. Uno, Samuel K. Wasser, and Xiaomei Xu
  
  PNAS November 22, 2016 113 (47) 13330-13335; first published November 7, 2016. https://doi.org/10.1073/pnas.1614938113
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  Recent acceleration in coastal cliff retreat rates on the south coast of Great Britain
  Martin D. Hurst, Dylan H. Rood, Michael A. Ellis, Robert S. Anderson, and Uwe Dornbusch
  
  PNAS November 22, 2016 113 (47) 13336-13341; first published November 7, 2016. https://doi.org/10.1073/pnas.1613044113
Environmental Sciences
- Open Access
  Molecular and physiological evidence of genetic assimilation to high CO₂ in the marine nitrogen fixer Trichodesmium
  Nathan G. Walworth, Michael D. Lee, Fei-Xue Fu, David A. Hutchins, and Eric A. Webb
  
  PNAS November 22, 2016 113 (47) E7367-E7374; first published November 8, 2016. https://doi.org/10.1073/pnas.1605202113
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  Coastal sea level rise with warming above 2 °C
  Svetlana Jevrejeva, Luke P. Jackson, Riccardo E. M. Riva, Aslak Grinsted, and John C. Moore
  
  PNAS November 22, 2016 113 (47) 13342-13347; first published November 7, 2016. https://doi.org/10.1073/pnas.1605312113
Physics
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  Phase diagram and thermal expansion measurements on the system URu_2−xFe_xSi₂
  Sheng Ran, Christian T. Wolowiec, Inho Jeon, Naveen Pouse, Noravee Kanchanavatee, Benjamin D. White, Kevin Huang, Dinesh Martien, Tyler DaPron, David Snow, Mark Williamsen, Stefano Spagna, Peter S. Riseborough, and M. Brian Maple
  
  PNAS November 22, 2016 113 (47) 13348-13353; first published November 8, 2016. https://doi.org/10.1073/pnas.1616542113

Biological Sciences

Agricultural Sciences
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  Disease resistance through impairment of α-SNAP–NSF interaction and vesicular trafficking by soybean Rhg1
  Adam M. Bayless, John M. Smith, Junqi Song, Patrick H. McMinn, Alice Teillet, Benjamin K. August, and Andrew F. Bent
  
  PNAS November 22, 2016 113 (47) E7375-E7382; first published November 7, 2016. https://doi.org/10.1073/pnas.1610150113
Applied Biological Sciences
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  Ultrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)
  Fabrice Gielen, Raphaelle Hours, Stephane Emond, Martin Fischlechner, Ursula Schell, and Florian Hollfelder
  
  PNAS November 22, 2016 113 (47) E7383-E7389; first published November 7, 2016. https://doi.org/10.1073/pnas.1606927113
Biochemistry
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  Emulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesis
  Dana Yaffe, Ariela Vergara-Jaque, Lucy R. Forrest, and Shimon Schuldiner
  
  PNAS November 22, 2016 113 (47) E7390-E7398; first published November 7, 2016. https://doi.org/10.1073/pnas.1605162113
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  Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel
  George Vaisey, Alexandria N. Miller, and Stephen B. Long
  
  PNAS November 22, 2016 113 (47) E7399-E7408; first published November 7, 2016. https://doi.org/10.1073/pnas.1614688113
- Open Access
  Control of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequences
  Masahiko Imashimizu, Ariel Afek, Hiroki Takahashi, Lucyna Lubkowska, and David B. Lukatsky
  
  PNAS November 22, 2016 113 (47) E7409-E7417; first published November 8, 2016. https://doi.org/10.1073/pnas.1607760113
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  Synthetic genome readers target clustered binding sites across diverse chromatin states
  Graham S. Erwin, Matthew P. Grieshop, Devesh Bhimsaria, Truman J. Do, José A. Rodríguez-Martínez, Charu Mehta, Kanika Khanna, Scott A. Swanson, Ron Stewart, James A. Thomson, Parameswaran Ramanathan, and Aseem Z. Ansari
  
  PNAS November 22, 2016 113 (47) E7418-E7427; first published November 8, 2016. https://doi.org/10.1073/pnas.1604847113
- Open Access
  Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
  Siarhei Kharytonchyk, Sarah Monti, Philip J. Smaldino, Verna Van, Nicholas C. Bolden, Joshua D. Brown, Emily Russo, Canessa Swanson, Alex Shuey, Alice Telesnitsky, and Michael F. Summers
  
  PNAS November 22, 2016 113 (47) 13378-13383; first published November 9, 2016. https://doi.org/10.1073/pnas.1616627113
- Open Access
  Cross-linking reveals laminin coiled-coil architecture
  Gad Armony, Etai Jacob, Toot Moran, Yishai Levin, Tevie Mehlman, Yaakov Levy, and Deborah Fass
  
  PNAS November 22, 2016 113 (47) 13384-13389; first published November 4, 2016. https://doi.org/10.1073/pnas.1608424113
- Open Access
  Archaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCM
  Yuli Xu, Tamzin Gristwood, Ben Hodgson, Jonathan C. Trinidad, Sonja-Verena Albers, and Stephen D. Bell
  
  PNAS November 22, 2016 113 (47) 13390-13395; first published November 7, 2016. https://doi.org/10.1073/pnas.1613825113
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  X-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerization
  Jan Löwe, Shaoda He, Sjors H. W. Scheres, and Christos G. Savva
  
  PNAS November 22, 2016 113 (47) 13396-13401; first published November 7, 2016. https://doi.org/10.1073/pnas.1612034113
Biophysics and Computational Biology
- Open Access
  Model-based transcriptome engineering promotes a fermentative transcriptional state in yeast
  Drew G. Michael, Ezekiel J. Maier, Holly Brown, Stacey R. Gish, Christopher Fiore, Randall H. Brown, and Michael R. Brent
  
  PNAS November 22, 2016 113 (47) E7428-E7437; first published November 3, 2016. https://doi.org/10.1073/pnas.1603577113
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  Tertiary alphabet for the observable protein structural universe
  Craig O. Mackenzie, Jianfu Zhou, and Gevorg Grigoryan
  
  PNAS November 22, 2016 113 (47) E7438-E7447; first published November 3, 2016. https://doi.org/10.1073/pnas.1607178113
- Open Access
  Highly selective inhibition of myosin motors provides the basis of potential therapeutic application
  Serena Sirigu, James J. Hartman, Vicente José Planelles-Herrero, Virginie Ropars, Sheila Clancy, Xi Wang, Grace Chuang, Xiangping Qian, Pu-Ping Lu, Edward Barrett, Karin Rudolph, Christopher Royer, Bradley P. Morgan, Enrico A. Stura, Fady I. Malik, and Anne M. Houdusse
  
  PNAS November 22, 2016 113 (47) E7448-E7455; first published November 4, 2016. https://doi.org/10.1073/pnas.1609342113
- Open Access
  Design of a molecular support for cryo-EM structure determination
  Thomas G. Martin, Tanmay A. M. Bharat, Andreas C. Joerger, Xiao-chen Bai, Florian Praetorius, Alan R. Fersht, Hendrik Dietz, and Sjors H. W. Scheres
  
  PNAS November 22, 2016 113 (47) E7456-E7463; first published November 7, 2016. https://doi.org/10.1073/pnas.1612720113
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  Red cells’ dynamic morphologies govern blood shear thinning under microcirculatory flow conditions
  Luca Lanotte, Johannes Mauer, Simon Mendez, Dmitry A. Fedosov, Jean-Marc Fromental, Viviana Claveria, Franck Nicoud, Gerhard Gompper, and Manouk Abkarian
  
  PNAS November 22, 2016 113 (47) 13289-13294; first published November 9, 2016. https://doi.org/10.1073/pnas.1608074113
- Open Access
  Quantitative determination of ribosome nascent chain stability
  Avi J. Samelson, Madeleine K. Jensen, Randy A. Soto, Jamie H. D. Cate, and Susan Marqusee
  
  PNAS November 22, 2016 113 (47) 13402-13407; first published November 7, 2016. https://doi.org/10.1073/pnas.1610272113
Cell Biology
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  A Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosis
  Alexander Junemann, Vedrana Filić, Moritz Winterhoff, Benjamin Nordholz, Christof Litschko, Helena Schwellenbach, Till Stephan, Igor Weber, and Jan Faix
  
  PNAS November 22, 2016 113 (47) E7464-E7473; first published November 7, 2016. https://doi.org/10.1073/pnas.1611024113
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  Protein aggregation as a cellular response to oxidative stress induced by heme and iron
  Luiz R. C. Vasconcellos, Fabianno F. Dutra, Mariana S. Siqueira, Heitor A. Paula-Neto, Jennifer Dahan, Ellen Kiarely, Leticia A. M. Carneiro, Marcelo T. Bozza, and Leonardo H. Travassos
  
  PNAS November 22, 2016 113 (47) E7474-E7482; first published November 7, 2016. https://doi.org/10.1073/pnas.1608928113
- Open Access
  Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism
  Mishan Britto, Adeline Goulet, Syeda Rizvi, Ottilie von Loeffelholz, Carolyn A. Moores, and Robert A. Cross
  
  PNAS November 22, 2016 113 (47) E7483-E7489; first published November 9, 2016. https://doi.org/10.1073/pnas.1611581113
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  p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome
  From the Cover
  
  Victoria Cohen-Kaplan, Ido Livneh, Noa Avni, Bertrand Fabre, Tamar Ziv, Yong Tae Kwon, and Aaron Ciechanover
  
  PNAS November 22, 2016 113 (47) E7490-E7499; first published October 17, 2016. https://doi.org/10.1073/pnas.1615455113
  
  See companion article:
  How the proteasome is degraded
  - Nov 11, 2016
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  Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks
  Yulia Artemenko, Lucas Axiotakis Jr., Jane Borleis, Pablo A. Iglesias, and Peter N. Devreotes
  
  PNAS November 22, 2016 113 (47) E7500-E7509; first published November 7, 2016. https://doi.org/10.1073/pnas.1608767113
Developmental Biology
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  Spatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina
  From the Cover
  
  Christine E. Larkins, Ana B. Enriquez, and Martin J. Cohn
  
  PNAS November 22, 2016 113 (47) E7510-E7517; first published November 7, 2016. https://doi.org/10.1073/pnas.1610471113
- Open Access
  Epithelial cell integrin β1 is required for developmental angiogenesis in the pituitary gland
  Kathleen M. Scully, Dorota Skowronska-Krawczyk, Michal Krawczyk, Daria Merkurjev, Havilah Taylor, Antonia Livolsi, Jessica Tollkuhn, Radu V. Stan, and Michael G. Rosenfeld
  
  PNAS November 22, 2016 113 (47) 13408-13413; first published November 3, 2016. https://doi.org/10.1073/pnas.1614970113
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  Regulation of embryonic neurogenesis by germinal zone vasculature
  Mathew Tata, Ivan Wall, Andy Joyce, Joaquim M. Vieira, Nicoletta Kessaris, and Christiana Ruhrberg
  
  PNAS November 22, 2016 113 (47) 13414-13419; first published November 7, 2016. https://doi.org/10.1073/pnas.1613113113
Ecology
- Open Access
  Radiocarbon dating of seized ivory confirms rapid decline in African elephant populations and provides insight into illegal trade
  From the Cover
  
  Thure E. Cerling, Janet E. Barnette, Lesley A. Chesson, Iain Douglas-Hamilton, Kathleen S. Gobush, Kevin T. Uno, Samuel K. Wasser, and Xiaomei Xu
  
  PNAS November 22, 2016 113 (47) 13330-13335; first published November 7, 2016. https://doi.org/10.1073/pnas.1614938113
- Open Access
  How social structures, space, and behaviors shape the spread of infectious diseases using chikungunya as a case study
  Henrik Salje, Justin Lessler, Kishor Kumar Paul, Andrew S. Azman, M. Waliur Rahman, Mahmudur Rahman, Derek Cummings, Emily S. Gurley, and Simon Cauchemez
  
  PNAS November 22, 2016 113 (47) 13420-13425; first published November 7, 2016. https://doi.org/10.1073/pnas.1611391113
Evolution
- Open Access
  An oscillating tragedy of the commons in replicator dynamics with game-environment feedback
  Joshua S. Weitz, Ceyhun Eksin, Keith Paarporn, Sam P. Brown, and William C. Ratcliff
  
  PNAS November 22, 2016 113 (47) E7518-E7525; first published November 8, 2016. https://doi.org/10.1073/pnas.1604096113
- Open Access
  Molecular and physiological evidence of genetic assimilation to high CO₂ in the marine nitrogen fixer Trichodesmium
  Nathan G. Walworth, Michael D. Lee, Fei-Xue Fu, David A. Hutchins, and Eric A. Webb
  
  PNAS November 22, 2016 113 (47) E7367-E7374; first published November 8, 2016. https://doi.org/10.1073/pnas.1605202113
Genetics
- Open Access
  Genetic variants linked to education predict longevity
  From the Cover
  
  Riccardo E. Marioni, Stuart J. Ritchie, Peter K. Joshi, Saskia P. Hagenaars, Aysu Okbay, Krista Fischer, Mark J. Adams, W. David Hill, Gail Davies, Social Science Genetic Association Consortium, Reka Nagy, Carmen Amador, Kristi Läll, Andres Metspalu, David C. Liewald, Archie Campbell, James F. Wilson, Caroline Hayward, Tõnu Esko, David J. Porteous, Catharine R. Gale, and Ian J. Deary
  
  PNAS November 22, 2016 113 (47) 13366-13371; first published October 31, 2016. https://doi.org/10.1073/pnas.1605334113
  
  See companion article:
  Genotyping the dead
  - Nov 11, 2016
- Open Access
  Selective nucleolus organizer inactivation in Arabidopsis is a chromosome position-effect phenomenon
  Gireesha Mohannath, Frederic Pontvianne, and Craig S. Pikaard
  
  PNAS November 22, 2016 113 (47) 13426-13431; first published November 7, 2016. https://doi.org/10.1073/pnas.1608140113
- Open Access
  High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma
  Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, Masaki Ohmuraya, Ayuko Sato, Tohru Tsujimura, Seiki Hasegawa, Takashi Nakano, Masaki Nasu, Sandra Pastorino, Agata Szymiczek, Angela Bononi, Mika Tanji, Ian Pagano, Giovanni Gaudino, Andrea Napolitano, Chandra Goparaju, Harvey I. Pass, Haining Yang, and Michele Carbone
  
  PNAS November 22, 2016 113 (47) 13432-13437; first published November 9, 2016. https://doi.org/10.1073/pnas.1612074113
Immunology and Inflammation
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  Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer
  George J. Xu, Ami A. Shah, Mamie Z. Li, Qikai Xu, Antony Rosen, Livia Casciola-Rosen, and Stephen J. Elledge
  
  PNAS November 22, 2016 113 (47) E7526-E7534; first published November 7, 2016. https://doi.org/10.1073/pnas.1615990113
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  Keratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205
  Longxing Cao, Haishuang Chang, Xiangyi Shi, Chao Peng, and Yongning He
  
  PNAS November 22, 2016 113 (47) 13438-13443; first published November 7, 2016. https://doi.org/10.1073/pnas.1609331113
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  Stress-induced brain activity, brain atrophy, and clinical disability in multiple sclerosis
  Martin Weygandt, Lil Meyer-Arndt, Janina Ruth Behrens, Katharina Wakonig, Judith Bellmann-Strobl, Kerstin Ritter, Michael Scheel, Alexander U. Brandt, Christian Labadie, Stefan Hetzer, Stefan M. Gold, Friedemann Paul, and John-Dylan Haynes
  
  PNAS November 22, 2016 113 (47) 13444-13449; first published November 7, 2016. https://doi.org/10.1073/pnas.1605829113
Medical Sciences
- Open Access
  Epigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancer
  Angel Diaz-Lagares, Ana B. Crujeiras, Paula Lopez-Serra, Marta Soler, Fernando Setien, Ashish Goyal, Juan Sandoval, Yutaka Hashimoto, Anna Martinez-Cardús, Antonio Gomez, Holger Heyn, Catia Moutinho, Jesús Espada, August Vidal, Maria Paúles, Maica Galán, Núria Sala, Yoshimitsu Akiyama, María Martínez-Iniesta, Lourdes Farré, Alberto Villanueva, Matthias Gross, Sven Diederichs, Sonia Guil, and Manel Esteller
  
  PNAS November 22, 2016 113 (47) E7535-E7544; first published November 7, 2016. https://doi.org/10.1073/pnas.1608585113
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  Control of inflammation by stromal Hedgehog pathway activation restrains colitis
  John J. Lee, Michael E. Rothenberg, E. Scott Seeley, Bryan Zimdahl, Sally Kawano, Wan-Jin Lu, Kunyoo Shin, Tomoyo Sakata-Kato, James K. Chen, Maximilian Diehn, Michael F. Clarke, and Philip A. Beachy
  
  PNAS November 22, 2016 113 (47) E7545-E7553; first published November 4, 2016. https://doi.org/10.1073/pnas.1616447113
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  Hydrogel films and coatings by swelling-induced gelation
  David Moreau, Caroline Chauvet, François Etienne, François P. Rannou, and Laurent Corté
  
  PNAS November 22, 2016 113 (47) 13295-13300; first published November 7, 2016. https://doi.org/10.1073/pnas.1609603113
- Open Access
  Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia
  Feng Li, Tomofumi Fushima, Gen Oyanagi, H. W. Davin Townley-Tilson, Emiko Sato, Hironobu Nakada, Yuji Oe, John R. Hagaman, Jennifer Wilder, Manyu Li, Akiyo Sekimoto, Daisuke Saigusa, Hiroshi Sato, Sadayoshi Ito, J. Charles Jennette, Nobuyo Maeda, S. Ananth Karumanchi, Oliver Smithies, and Nobuyuki Takahashi
  
  PNAS November 22, 2016 113 (47) 13450-13455; first published November 7, 2016. https://doi.org/10.1073/pnas.1614947113
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  Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer
  Ross A. Okimoto, Luping Lin, Victor Olivas, Elton Chan, Evan Markegard, Andrey Rymar, Dana Neel, Xiao Chen, Golzar Hemmati, Gideon Bollag, and Trever G. Bivona
  
  PNAS November 22, 2016 113 (47) 13456-13461; first published November 9, 2016. https://doi.org/10.1073/pnas.1610456113
Microbiology
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  Gut microbiota induce IGF-1 and promote bone formation and growth
  Jing Yan, Jeremy W. Herzog, Kelly Tsang, Caitlin A. Brennan, Maureen A. Bower, Wendy S. Garrett, Balfour R. Sartor, Antonios O. Aliprantis, and Julia F. Charles
  
  PNAS November 22, 2016 113 (47) E7554-E7563; first published November 7, 2016. https://doi.org/10.1073/pnas.1607235113
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  Siderophore-based immunization strategy to inhibit growth of enteric pathogens
  Martina Sassone-Corsi, Phoom Chairatana, Tengfei Zheng, Araceli Perez-Lopez, Robert A. Edwards, Michael D. George, Elizabeth M. Nolan, and Manuela Raffatellu
  
  PNAS November 22, 2016 113 (47) 13462-13467; first published November 7, 2016. https://doi.org/10.1073/pnas.1606290113
  
  See companion article:
  Siderophore vaccine protects against UTI
  - Nov 07, 2016
- You have access
  Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection
  Laura A. Mike, Sara N. Smith, Christopher A. Sumner, Kathryn A. Eaton, and Harry L. T. Mobley
  
  PNAS November 22, 2016 113 (47) 13468-13473; first published November 7, 2016. https://doi.org/10.1073/pnas.1606324113
  
  See companion article:
  Siderophore-based immunization inhibits pathogens
  - Nov 07, 2016
Neuroscience
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  Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons
  Carmen R. Sunico, Abdullah Sultan, Tomohiro Nakamura, Nima Dolatabadi, James Parker, Bing Shan, Xuemei Han, John R. Yates III, Eliezer Masliah, Rajesh Ambasudhan, Nobuki Nakanishi, and Stuart A. Lipton
  
  PNAS November 22, 2016 113 (47) E7564-E7571; first published November 7, 2016. https://doi.org/10.1073/pnas.1608784113
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  IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
  Boyi Liu, Yan Tai, Satyanarayana Achanta, Melanie M. Kaelberer, Ana I. Caceres, Xiaomei Shao, Jianqiao Fang, and Sven-Eric Jordt
  
  PNAS November 22, 2016 113 (47) E7572-E7579; first published November 7, 2016. https://doi.org/10.1073/pnas.1606608113
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  Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutations
  Nhat T. T. Le, Lydia Chang, Irina Kovlyagina, Polymnia Georgiou, Nathaniel Safren, Kerstin E. Braunstein, Mark D. Kvarta, Adam M. Van Dyke, Tara A. LeGates, Thomas Philips, Brett M. Morrison, Scott M. Thompson, Adam C. Puche, Todd D. Gould, Jeffrey D. Rothstein, Philip C. Wong, and Mervyn J. Monteiro
  
  PNAS November 22, 2016 113 (47) E7580-E7589; first published November 9, 2016. https://doi.org/10.1073/pnas.1608432113
- Open Access
  C-terminal domain of mammalian complexin-1 localizes to highly curved membranes
  Jihong Gong, Ying Lai, Xiaohong Li, Mengxian Wang, Jeremy Leitz, Yachong Hu, Yunxiang Zhang, Ucheor B. Choi, Daniel Cipriano, Richard A. Pfuetzner, Thomas C. Südhof, Xiaofei Yang, Axel T. Brunger, and Jiajie Diao
  
  PNAS November 22, 2016 113 (47) E7590-E7599; first published November 7, 2016. https://doi.org/10.1073/pnas.1609917113
- Open Access
  Reduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS mice
  Muhamed Hadzipasic, Weiming Ni, Maria Nagy, Natalie Steenrod, Matthew J. McGinley, Adi Kaushal, Eleanor Thomas, David A. McCormick, and Arthur L. Horwich
  
  PNAS November 22, 2016 113 (47) E7600-E7609; first published November 7, 2016. https://doi.org/10.1073/pnas.1616832113
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  Autobiographical memory, future imagining, and the medial temporal lobe
  Adam J. O. Dede, John T. Wixted, Ramona O. Hopkins, and Larry R. Squire
  
  PNAS November 22, 2016 113 (47) 13474-13479; first published November 7, 2016. https://doi.org/10.1073/pnas.1615864113
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  Learning and remembering real-world events after medial temporal lobe damage
  Adam J. O. Dede, Jennifer C. Frascino, John T. Wixted, and Larry R. Squire
  
  PNAS November 22, 2016 113 (47) 13480-13485; first published November 7, 2016. https://doi.org/10.1073/pnas.1617025113
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  Quasimodo mediates daily and acute light effects on Drosophila clock neuron excitability
  Edgar Buhl, Adam Bradlaugh, Maite Ogueta, Ko-Fan Chen, Ralf Stanewsky, and James J. L. Hodge
  
  PNAS November 22, 2016 113 (47) 13486-13491; first published November 7, 2016. https://doi.org/10.1073/pnas.1606547113
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  Temporal coding of reward-guided choice in the posterior parietal cortex
  David J. Hawellek, Yan T. Wong, and Bijan Pesaran
  
  PNAS November 22, 2016 113 (47) 13492-13497; first published November 7, 2016. https://doi.org/10.1073/pnas.1606479113
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  The cholinergic forebrain arousal system acts directly on the circadian pacemaker
  Glenn R. Yamakawa, Priyoneel Basu, Filomeno Cortese, Johanna MacDonnell, Danica Whalley, Victoria M. Smith, and Michael C. Antle
  
  PNAS November 22, 2016 113 (47) 13498-13503; first published November 7, 2016. https://doi.org/10.1073/pnas.1610342113
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  Diffusion-weighted imaging uncovers likely sources of processing-speed deficits in schizophrenia
  Peter Kochunov, Laura M. Rowland, Els Fieremans, Jelle Veraart, Neda Jahanshad, George Eskandar, Xiaoming Du, Florian Muellerklein, Anya Savransky, Dinesh Shukla, Hemalatha Sampath, Paul M. Thompson, and L. Elliot Hong
  
  PNAS November 22, 2016 113 (47) 13504-13509; first published November 9, 2016. https://doi.org/10.1073/pnas.1608246113
- Open Access
  Relationships between cortical myeloarchitecture and electrophysiological networks
  Benjamin A. E. Hunt, Prejaas K. Tewarie, Olivier E. Mougin, Nicolas Geades, Derek K. Jones, Krish D. Singh, Peter G. Morris, Penny A. Gowland, and Matthew J. Brookes
  
  PNAS November 22, 2016 113 (47) 13510-13515; first published November 8, 2016. https://doi.org/10.1073/pnas.1608587113
- Open Access
  Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2
  Tetsuya Gotoh, Jae Kyoung Kim, Jingjing Liu, Marian Vila-Caballer, Philip E. Stauffer, John J. Tyson, and Carla V. Finkielstein
  
  PNAS November 22, 2016 113 (47) 13516-13521; first published November 9, 2016. https://doi.org/10.1073/pnas.1607984113
Physiology
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  Decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfecta
  Arin K. Oestreich, William M. Kamp, Marcus G. McCray, Stephanie M. Carleton, Natalia Karasseva, Kristin L. Lenz, Youngjae Jeong, Salah A. Daghlas, Xiaomei Yao, Yong Wang, Ferris M. Pfeiffer, Mark R. Ellersieck, Laura C. Schulz, and Charlotte L. Phillips
  
  PNAS November 22, 2016 113 (47) 13522-13527; first published November 7, 2016. https://doi.org/10.1073/pnas.1607644113
Plant Biology
- Open Access
  Illuminating a plant’s tissue-specific metabolic diversity using computational metabolomics and information theory
  Dapeng Li, Sven Heiling, Ian T. Baldwin, and Emmanuel Gaquerel
  
  PNAS November 22, 2016 113 (47) E7610-E7618; first published November 7, 2016. https://doi.org/10.1073/pnas.1610218113
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  The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii
  Maxim Itkin, Rachel Davidovich-Rikanati, Shahar Cohen, Vitaly Portnoy, Adi Doron-Faigenboim, Elad Oren, Shiri Freilich, Galil Tzuri, Nadine Baranes, Shmuel Shen, Marina Petreikov, Rotem Sertchook, Shifra Ben-Dor, Hugo Gottlieb, Alvaro Hernandez, David R. Nelson, Harry S. Paris, Yaakov Tadmor, Yosef Burger, Efraim Lewinsohn, Nurit Katzir, and Arthur Schaffer
  
  PNAS November 22, 2016 113 (47) E7619-E7628; first published November 7, 2016. https://doi.org/10.1073/pnas.1604828113
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  Chloroplast division checkpoint in eukaryotic algae
  Nobuko Sumiya, Takayuki Fujiwara, Atsuko Era, and Shin-ya Miyagishima
  
  PNAS November 22, 2016 113 (47) E7629-E7638; first published November 11, 2016. https://doi.org/10.1073/pnas.1612872113
Systems Biology
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  Engineering dynamical control of cell fate switching using synthetic phospho-regulons
  Russell M. Gordley, Reid E. Williams, Caleb J. Bashor, Jared E. Toettcher, Shude Yan, and Wendell A. Lim
  
  PNAS November 22, 2016 113 (47) 13528-13533; first published November 7, 2016. https://doi.org/10.1073/pnas.1610973113

Corrections (Online Only)

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Correction for Mantelli et al., Stochastic ice stream dynamics
PNAS November 22, 2016 113 (47) E7639; https://doi.org/10.1073/pnas.1616623113
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Correction for Biswas et al., E-cadherin junction formation involves an active kinetic nucleation process
PNAS November 22, 2016 113 (47) E7640; first published November 14, 2016. https://doi.org/10.1073/pnas.1617360113
You have access
Correction for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility
PNAS November 22, 2016 113 (47) E7641-E7642; first published November 14, 2016. https://doi.org/10.1073/pnas.1616959113
You have access
Correction for Ren et al., LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
PNAS November 22, 2016 113 (47) E7643-E7644; first published November 14, 2016. https://doi.org/10.1073/pnas.1616960113

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