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Table of Contents
November 22, 2016; vol. 113 no. 47
This Week in PNAS
Letters (Online Only)
- You have accessQuestionable association between front boarding and air rageMarcus Crede, Andrew Gelman, and Carol NickersonPNAS November 22, 2016 113 (47) E7348; first published November 11, 2016. https://doi.org/10.1073/pnas.1611704113
- You have accessReply to Crede et al.: Association between front boarding and air rage is supported by theory and analysisKatherine A. DeCelles and Michael I. NortonPNAS November 22, 2016 113 (47) E7349-E7350; first published November 11, 2016. https://doi.org/10.1073/pnas.1614434113
See companion article:
- Inequality on airplanes predicts air rage- May 02, 2016
Science and Culture
How science intersects with culture.
- You have accessScience and Culture: Crafting prostheses with form, function, and flair
- Front Matter
Esther Landhuis
Core Concepts
A brief introduction to emerging topics in science.
- You have accessCore Concept: Can bioenergy with carbon capture and storage make an impact?
- Front Matter
Danielle Venton
PNAS Plus Significance Statements
Brief statements written by the authors about the significance of their papers.
Physical Sciences
Applied Mathematics
- Open AccessA variational perspective on accelerated methods in optimizationAndre Wibisono, Ashia C. Wilson, and Michael I. JordanPNAS November 22, 2016 113 (47) E7351-E7358; first published November 9, 2016. https://doi.org/10.1073/pnas.1614734113
- You have accessSupercritical entanglement in local systems: Counterexample to the area law for quantum matterRamis Movassagh and Peter W. ShorPNAS November 22, 2016 113 (47) 13278-13282; first published November 7, 2016. https://doi.org/10.1073/pnas.1605716113
- You have accessOptimal prediction of the number of unseen speciesAlon Orlitsky, Ananda Theertha Suresh, and Yihong WuPNAS November 22, 2016 113 (47) 13283-13288; first published November 8, 2016. https://doi.org/10.1073/pnas.1607774113
Applied Physical Sciences
- You have accessUltrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)Fabrice Gielen, Raphaelle Hours, Stephane Emond, Martin Fischlechner, Ursula Schell, and Florian HollfelderPNAS November 22, 2016 113 (47) E7383-E7389; first published November 7, 2016. https://doi.org/10.1073/pnas.1606927113
- You have accessRed cells’ dynamic morphologies govern blood shear thinning under microcirculatory flow conditionsLuca Lanotte, Johannes Mauer, Simon Mendez, Dmitry A. Fedosov, Jean-Marc Fromental, Viviana Claveria, Franck Nicoud, Gerhard Gompper, and Manouk AbkarianPNAS November 22, 2016 113 (47) 13289-13294; first published November 9, 2016. https://doi.org/10.1073/pnas.1608074113
- You have accessHydrogel films and coatings by swelling-induced gelationDavid Moreau, Caroline Chauvet, François Etienne, François P. Rannou, and Laurent CortéPNAS November 22, 2016 113 (47) 13295-13300; first published November 7, 2016. https://doi.org/10.1073/pnas.1609603113
- You have accessAccelerated search for BaTiO3-based piezoelectrics with vertical morphotropic phase boundary using Bayesian learningDezhen Xue, Prasanna V. Balachandran, Ruihao Yuan, Tao Hu, Xiaoning Qian, Edward R. Dougherty, and Turab LookmanPNAS November 22, 2016 113 (47) 13301-13306; first published November 7, 2016. https://doi.org/10.1073/pnas.1607412113
- You have accessSuperhydrophobicity enhancement through substrate flexibilityThomas Vasileiou, Julia Gerber, Jana Prautzsch, Thomas M. Schutzius, and Dimos PoulikakosPNAS November 22, 2016 113 (47) 13307-13312; first published November 9, 2016. https://doi.org/10.1073/pnas.1611631113
Chemistry
- You have accessMastering the interface for advanced all-solid-state lithium rechargeable batteriesYutao Li, Weidong Zhou, Xi Chen, Xujie Lü, Zhiming Cui, Sen Xin, Leigang Xue, Quanxi Jia, and John B. GoodenoughPNAS November 22, 2016 113 (47) 13313-13317; first published November 7, 2016. https://doi.org/10.1073/pnas.1615912113
- You have accessOne low-dose exposure of gold nanoparticles induces long-term changes in human cellsPriscila Falagan-Lotsch, Elissa M. Grzincic, and Catherine J. MurphyPNAS November 22, 2016 113 (47) 13318-13323; first published November 7, 2016. https://doi.org/10.1073/pnas.1616400113
- You have accessIn situ solid-state electrochemistry of mass-selected ions at well-defined electrode–electrolyte interfacesVenkateshkumar Prabhakaran, Grant E. Johnson, Bingbing Wang, and Julia LaskinPNAS November 22, 2016 113 (47) 13324-13329; first published November 7, 2016. https://doi.org/10.1073/pnas.1608730113
- You have accessSiderophore-based immunization strategy to inhibit growth of enteric pathogensMartina Sassone-Corsi, Phoom Chairatana, Tengfei Zheng, Araceli Perez-Lopez, Robert A. Edwards, Michael D. George, Elizabeth M. Nolan, and Manuela RaffatelluPNAS November 22, 2016 113 (47) 13462-13467; first published November 7, 2016. https://doi.org/10.1073/pnas.1606290113
See companion article:
- Siderophore vaccine protects against UTI- Nov 07, 2016
- You have accessSiderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infectionLaura A. Mike, Sara N. Smith, Christopher A. Sumner, Kathryn A. Eaton, and Harry L. T. MobleyPNAS November 22, 2016 113 (47) 13468-13473; first published November 7, 2016. https://doi.org/10.1073/pnas.1606324113
See companion article:
- Siderophore-based immunization inhibits pathogens- Nov 07, 2016
Earth, Atmospheric, and Planetary Sciences
- You have accessRapid conversion of an oceanic spreading center to a subduction zone inferred from high-precision geochronologyTimothy E. Keenan, John Encarnación, Robert Buchwaldt, Dan Fernandez, James Mattinson, Christine Rasoazanamparany, and P. Benjamin LuetkemeyerPNAS November 22, 2016 113 (47) E7359-E7366; first published November 7, 2016. https://doi.org/10.1073/pnas.1609999113
- Open AccessRadiocarbon dating of seized ivory confirms rapid decline in African elephant populations and provides insight into illegal trade
- From the Cover
Thure E. Cerling, Janet E. Barnette, Lesley A. Chesson, Iain Douglas-Hamilton, Kathleen S. Gobush, Kevin T. Uno, Samuel K. Wasser, and Xiaomei XuPNAS November 22, 2016 113 (47) 13330-13335; first published November 7, 2016. https://doi.org/10.1073/pnas.1614938113 - You have accessRecent acceleration in coastal cliff retreat rates on the south coast of Great BritainMartin D. Hurst, Dylan H. Rood, Michael A. Ellis, Robert S. Anderson, and Uwe DornbuschPNAS November 22, 2016 113 (47) 13336-13341; first published November 7, 2016. https://doi.org/10.1073/pnas.1613044113
Environmental Sciences
- Open AccessMolecular and physiological evidence of genetic assimilation to high CO2 in the marine nitrogen fixer TrichodesmiumNathan G. Walworth, Michael D. Lee, Fei-Xue Fu, David A. Hutchins, and Eric A. WebbPNAS November 22, 2016 113 (47) E7367-E7374; first published November 8, 2016. https://doi.org/10.1073/pnas.1605202113
- You have accessCoastal sea level rise with warming above 2 °CSvetlana Jevrejeva, Luke P. Jackson, Riccardo E. M. Riva, Aslak Grinsted, and John C. MoorePNAS November 22, 2016 113 (47) 13342-13347; first published November 7, 2016. https://doi.org/10.1073/pnas.1605312113
Physics
- You have accessPhase diagram and thermal expansion measurements on the system URu2−xFexSi2Sheng Ran, Christian T. Wolowiec, Inho Jeon, Naveen Pouse, Noravee Kanchanavatee, Benjamin D. White, Kevin Huang, Dinesh Martien, Tyler DaPron, David Snow, Mark Williamsen, Stefano Spagna, Peter S. Riseborough, and M. Brian MaplePNAS November 22, 2016 113 (47) 13348-13353; first published November 8, 2016. https://doi.org/10.1073/pnas.1616542113
Social Sciences
Economic Sciences
- Open AccessWhat grades and achievement tests measure
- From the Cover
Lex Borghans, Bart H. H. Golsteyn, James J. Heckman, and John Eric HumphriesPNAS November 22, 2016 113 (47) 13354-13359; first published November 8, 2016. https://doi.org/10.1073/pnas.1601135113
Psychological and Cognitive Sciences
- You have accessTwo-and-a-half-year-olds succeed at a traditional false-belief task with reduced processing demandsPeipei Setoh, Rose M. Scott, and Renée BaillargeonPNAS November 22, 2016 113 (47) 13360-13365; first published November 7, 2016. https://doi.org/10.1073/pnas.1609203113
See companion article:
- Early success with reduced processing demands- Apr 17, 2017
- You have accessAutobiographical memory, future imagining, and the medial temporal lobeAdam J. O. Dede, John T. Wixted, Ramona O. Hopkins, and Larry R. SquirePNAS November 22, 2016 113 (47) 13474-13479; first published November 7, 2016. https://doi.org/10.1073/pnas.1615864113
- You have accessLearning and remembering real-world events after medial temporal lobe damageAdam J. O. Dede, Jennifer C. Frascino, John T. Wixted, and Larry R. SquirePNAS November 22, 2016 113 (47) 13480-13485; first published November 7, 2016. https://doi.org/10.1073/pnas.1617025113
Social Sciences
- Open AccessGenetic variants linked to education predict longevity
- From the Cover
Riccardo E. Marioni, Stuart J. Ritchie, Peter K. Joshi, Saskia P. Hagenaars, Aysu Okbay, Krista Fischer, Mark J. Adams, W. David Hill, Gail Davies, Social Science Genetic Association Consortium, Reka Nagy, Carmen Amador, Kristi Läll, Andres Metspalu, David C. Liewald, Archie Campbell, James F. Wilson, Caroline Hayward, Tõnu Esko, David J. Porteous, Catharine R. Gale, and Ian J. DearyPNAS November 22, 2016 113 (47) 13366-13371; first published October 31, 2016. https://doi.org/10.1073/pnas.1605334113See companion article:
- Genotyping the dead- Nov 11, 2016
- Open AccessFor blacks in America, the gap in neighborhood poverty has declined faster than segregationGlenn Firebaugh and Francesco AcciaiPNAS November 22, 2016 113 (47) 13372-13377; first published November 7, 2016. https://doi.org/10.1073/pnas.1607220113
Sustainability Science
- You have accessCoastal sea level rise with warming above 2 °CSvetlana Jevrejeva, Luke P. Jackson, Riccardo E. M. Riva, Aslak Grinsted, and John C. MoorePNAS November 22, 2016 113 (47) 13342-13347; first published November 7, 2016. https://doi.org/10.1073/pnas.1605312113
Biological Sciences
Agricultural Sciences
- You have accessDisease resistance through impairment of α-SNAP–NSF interaction and vesicular trafficking by soybean Rhg1Adam M. Bayless, John M. Smith, Junqi Song, Patrick H. McMinn, Alice Teillet, Benjamin K. August, and Andrew F. BentPNAS November 22, 2016 113 (47) E7375-E7382; first published November 7, 2016. https://doi.org/10.1073/pnas.1610150113
Applied Biological Sciences
- You have accessUltrahigh-throughput–directed enzyme evolution by absorbance-activated droplet sorting (AADS)Fabrice Gielen, Raphaelle Hours, Stephane Emond, Martin Fischlechner, Ursula Schell, and Florian HollfelderPNAS November 22, 2016 113 (47) E7383-E7389; first published November 7, 2016. https://doi.org/10.1073/pnas.1606927113
Biochemistry
- You have accessEmulating proton-induced conformational changes in the vesicular monoamine transporter VMAT2 by mutagenesisDana Yaffe, Ariela Vergara-Jaque, Lucy R. Forrest, and Shimon SchuldinerPNAS November 22, 2016 113 (47) E7390-E7398; first published November 7, 2016. https://doi.org/10.1073/pnas.1605162113
- You have accessDistinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channelGeorge Vaisey, Alexandria N. Miller, and Stephen B. LongPNAS November 22, 2016 113 (47) E7399-E7408; first published November 7, 2016. https://doi.org/10.1073/pnas.1614688113
- Open AccessControl of transcriptional pausing by biased thermal fluctuations on repetitive genomic sequencesMasahiko Imashimizu, Ariel Afek, Hiroki Takahashi, Lucyna Lubkowska, and David B. LukatskyPNAS November 22, 2016 113 (47) E7409-E7417; first published November 8, 2016. https://doi.org/10.1073/pnas.1607760113
- You have accessSynthetic genome readers target clustered binding sites across diverse chromatin statesGraham S. Erwin, Matthew P. Grieshop, Devesh Bhimsaria, Truman J. Do, José A. Rodríguez-Martínez, Charu Mehta, Kanika Khanna, Scott A. Swanson, Ron Stewart, James A. Thomson, Parameswaran Ramanathan, and Aseem Z. AnsariPNAS November 22, 2016 113 (47) E7418-E7427; first published November 8, 2016. https://doi.org/10.1073/pnas.1604847113
- Open AccessTranscriptional start site heterogeneity modulates the structure and function of the HIV-1 genomeSiarhei Kharytonchyk, Sarah Monti, Philip J. Smaldino, Verna Van, Nicholas C. Bolden, Joshua D. Brown, Emily Russo, Canessa Swanson, Alex Shuey, Alice Telesnitsky, and Michael F. SummersPNAS November 22, 2016 113 (47) 13378-13383; first published November 9, 2016. https://doi.org/10.1073/pnas.1616627113
- Open AccessCross-linking reveals laminin coiled-coil architectureGad Armony, Etai Jacob, Toot Moran, Yishai Levin, Tevie Mehlman, Yaakov Levy, and Deborah FassPNAS November 22, 2016 113 (47) 13384-13389; first published November 4, 2016. https://doi.org/10.1073/pnas.1608424113
- Open AccessArchaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCMYuli Xu, Tamzin Gristwood, Ben Hodgson, Jonathan C. Trinidad, Sonja-Verena Albers, and Stephen D. BellPNAS November 22, 2016 113 (47) 13390-13395; first published November 7, 2016. https://doi.org/10.1073/pnas.1613825113
- You have accessX-ray and cryo-EM structures of monomeric and filamentous actin-like protein MamK reveal changes associated with polymerizationJan Löwe, Shaoda He, Sjors H. W. Scheres, and Christos G. SavvaPNAS November 22, 2016 113 (47) 13396-13401; first published November 7, 2016. https://doi.org/10.1073/pnas.1612034113
Biophysics and Computational Biology
- Open AccessModel-based transcriptome engineering promotes a fermentative transcriptional state in yeastDrew G. Michael, Ezekiel J. Maier, Holly Brown, Stacey R. Gish, Christopher Fiore, Randall H. Brown, and Michael R. BrentPNAS November 22, 2016 113 (47) E7428-E7437; first published November 3, 2016. https://doi.org/10.1073/pnas.1603577113
- You have accessTertiary alphabet for the observable protein structural universeCraig O. Mackenzie, Jianfu Zhou, and Gevorg GrigoryanPNAS November 22, 2016 113 (47) E7438-E7447; first published November 3, 2016. https://doi.org/10.1073/pnas.1607178113
- Open AccessHighly selective inhibition of myosin motors provides the basis of potential therapeutic applicationSerena Sirigu, James J. Hartman, Vicente José Planelles-Herrero, Virginie Ropars, Sheila Clancy, Xi Wang, Grace Chuang, Xiangping Qian, Pu-Ping Lu, Edward Barrett, Karin Rudolph, Christopher Royer, Bradley P. Morgan, Enrico A. Stura, Fady I. Malik, and Anne M. HoudussePNAS November 22, 2016 113 (47) E7448-E7455; first published November 4, 2016. https://doi.org/10.1073/pnas.1609342113
- Open AccessDesign of a molecular support for cryo-EM structure determinationThomas G. Martin, Tanmay A. M. Bharat, Andreas C. Joerger, Xiao-chen Bai, Florian Praetorius, Alan R. Fersht, Hendrik Dietz, and Sjors H. W. ScheresPNAS November 22, 2016 113 (47) E7456-E7463; first published November 7, 2016. https://doi.org/10.1073/pnas.1612720113
- You have accessRed cells’ dynamic morphologies govern blood shear thinning under microcirculatory flow conditionsLuca Lanotte, Johannes Mauer, Simon Mendez, Dmitry A. Fedosov, Jean-Marc Fromental, Viviana Claveria, Franck Nicoud, Gerhard Gompper, and Manouk AbkarianPNAS November 22, 2016 113 (47) 13289-13294; first published November 9, 2016. https://doi.org/10.1073/pnas.1608074113
- Open AccessQuantitative determination of ribosome nascent chain stabilityAvi J. Samelson, Madeleine K. Jensen, Randy A. Soto, Jamie H. D. Cate, and Susan MarquseePNAS November 22, 2016 113 (47) 13402-13407; first published November 7, 2016. https://doi.org/10.1073/pnas.1610272113
Cell Biology
- You have accessA Diaphanous-related formin links Ras signaling directly to actin assembly in macropinocytosis and phagocytosisAlexander Junemann, Vedrana Filić, Moritz Winterhoff, Benjamin Nordholz, Christof Litschko, Helena Schwellenbach, Till Stephan, Igor Weber, and Jan FaixPNAS November 22, 2016 113 (47) E7464-E7473; first published November 7, 2016. https://doi.org/10.1073/pnas.1611024113
- You have accessProtein aggregation as a cellular response to oxidative stress induced by heme and ironLuiz R. C. Vasconcellos, Fabianno F. Dutra, Mariana S. Siqueira, Heitor A. Paula-Neto, Jennifer Dahan, Ellen Kiarely, Leticia A. M. Carneiro, Marcelo T. Bozza, and Leonardo H. TravassosPNAS November 22, 2016 113 (47) E7474-E7482; first published November 7, 2016. https://doi.org/10.1073/pnas.1608928113
- Open AccessSchizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanismMishan Britto, Adeline Goulet, Syeda Rizvi, Ottilie von Loeffelholz, Carolyn A. Moores, and Robert A. CrossPNAS November 22, 2016 113 (47) E7483-E7489; first published November 9, 2016. https://doi.org/10.1073/pnas.1611581113
- You have accessp62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome
- From the Cover
Victoria Cohen-Kaplan, Ido Livneh, Noa Avni, Bertrand Fabre, Tamar Ziv, Yong Tae Kwon, and Aaron CiechanoverPNAS November 22, 2016 113 (47) E7490-E7499; first published October 17, 2016. https://doi.org/10.1073/pnas.1615455113See companion article:
- How the proteasome is degraded- Nov 11, 2016
- You have accessChemical and mechanical stimuli act on common signal transduction and cytoskeletal networksYulia Artemenko, Lucas Axiotakis Jr., Jane Borleis, Pablo A. Iglesias, and Peter N. DevreotesPNAS November 22, 2016 113 (47) E7500-E7509; first published November 7, 2016. https://doi.org/10.1073/pnas.1608767113
Developmental Biology
- You have accessSpatiotemporal dynamics of androgen signaling underlie sexual differentiation and congenital malformations of the urethra and vagina
- From the Cover
Christine E. Larkins, Ana B. Enriquez, and Martin J. CohnPNAS November 22, 2016 113 (47) E7510-E7517; first published November 7, 2016. https://doi.org/10.1073/pnas.1610471113 - Open AccessEpithelial cell integrin β1 is required for developmental angiogenesis in the pituitary glandKathleen M. Scully, Dorota Skowronska-Krawczyk, Michal Krawczyk, Daria Merkurjev, Havilah Taylor, Antonia Livolsi, Jessica Tollkuhn, Radu V. Stan, and Michael G. RosenfeldPNAS November 22, 2016 113 (47) 13408-13413; first published November 3, 2016. https://doi.org/10.1073/pnas.1614970113
- You have accessRegulation of embryonic neurogenesis by germinal zone vasculatureMathew Tata, Ivan Wall, Andy Joyce, Joaquim M. Vieira, Nicoletta Kessaris, and Christiana RuhrbergPNAS November 22, 2016 113 (47) 13414-13419; first published November 7, 2016. https://doi.org/10.1073/pnas.1613113113
Ecology
- Open AccessRadiocarbon dating of seized ivory confirms rapid decline in African elephant populations and provides insight into illegal trade
- From the Cover
Thure E. Cerling, Janet E. Barnette, Lesley A. Chesson, Iain Douglas-Hamilton, Kathleen S. Gobush, Kevin T. Uno, Samuel K. Wasser, and Xiaomei XuPNAS November 22, 2016 113 (47) 13330-13335; first published November 7, 2016. https://doi.org/10.1073/pnas.1614938113 - Open AccessHow social structures, space, and behaviors shape the spread of infectious diseases using chikungunya as a case studyHenrik Salje, Justin Lessler, Kishor Kumar Paul, Andrew S. Azman, M. Waliur Rahman, Mahmudur Rahman, Derek Cummings, Emily S. Gurley, and Simon CauchemezPNAS November 22, 2016 113 (47) 13420-13425; first published November 7, 2016. https://doi.org/10.1073/pnas.1611391113
Evolution
- Open AccessAn oscillating tragedy of the commons in replicator dynamics with game-environment feedbackJoshua S. Weitz, Ceyhun Eksin, Keith Paarporn, Sam P. Brown, and William C. RatcliffPNAS November 22, 2016 113 (47) E7518-E7525; first published November 8, 2016. https://doi.org/10.1073/pnas.1604096113
- Open AccessMolecular and physiological evidence of genetic assimilation to high CO2 in the marine nitrogen fixer TrichodesmiumNathan G. Walworth, Michael D. Lee, Fei-Xue Fu, David A. Hutchins, and Eric A. WebbPNAS November 22, 2016 113 (47) E7367-E7374; first published November 8, 2016. https://doi.org/10.1073/pnas.1605202113
Genetics
- Open AccessGenetic variants linked to education predict longevity
- From the Cover
Riccardo E. Marioni, Stuart J. Ritchie, Peter K. Joshi, Saskia P. Hagenaars, Aysu Okbay, Krista Fischer, Mark J. Adams, W. David Hill, Gail Davies, Social Science Genetic Association Consortium, Reka Nagy, Carmen Amador, Kristi Läll, Andres Metspalu, David C. Liewald, Archie Campbell, James F. Wilson, Caroline Hayward, Tõnu Esko, David J. Porteous, Catharine R. Gale, and Ian J. DearyPNAS November 22, 2016 113 (47) 13366-13371; first published October 31, 2016. https://doi.org/10.1073/pnas.1605334113See companion article:
- Genotyping the dead- Nov 11, 2016
- Open AccessSelective nucleolus organizer inactivation in Arabidopsis is a chromosome position-effect phenomenonGireesha Mohannath, Frederic Pontvianne, and Craig S. PikaardPNAS November 22, 2016 113 (47) 13426-13431; first published November 7, 2016. https://doi.org/10.1073/pnas.1608140113
- Open AccessHigh-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesotheliomaYoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, Masaki Ohmuraya, Ayuko Sato, Tohru Tsujimura, Seiki Hasegawa, Takashi Nakano, Masaki Nasu, Sandra Pastorino, Agata Szymiczek, Angela Bononi, Mika Tanji, Ian Pagano, Giovanni Gaudino, Andrea Napolitano, Chandra Goparaju, Harvey I. Pass, Haining Yang, and Michele CarbonePNAS November 22, 2016 113 (47) 13432-13437; first published November 9, 2016. https://doi.org/10.1073/pnas.1612074113
Immunology and Inflammation
- You have accessSystematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancerGeorge J. Xu, Ami A. Shah, Mamie Z. Li, Qikai Xu, Antony Rosen, Livia Casciola-Rosen, and Stephen J. ElledgePNAS November 22, 2016 113 (47) E7526-E7534; first published November 7, 2016. https://doi.org/10.1073/pnas.1615990113
- You have accessKeratin mediates the recognition of apoptotic and necrotic cells through dendritic cell receptor DEC205/CD205Longxing Cao, Haishuang Chang, Xiangyi Shi, Chao Peng, and Yongning HePNAS November 22, 2016 113 (47) 13438-13443; first published November 7, 2016. https://doi.org/10.1073/pnas.1609331113
- You have accessStress-induced brain activity, brain atrophy, and clinical disability in multiple sclerosisMartin Weygandt, Lil Meyer-Arndt, Janina Ruth Behrens, Katharina Wakonig, Judith Bellmann-Strobl, Kerstin Ritter, Michael Scheel, Alexander U. Brandt, Christian Labadie, Stefan Hetzer, Stefan M. Gold, Friedemann Paul, and John-Dylan HaynesPNAS November 22, 2016 113 (47) 13444-13449; first published November 7, 2016. https://doi.org/10.1073/pnas.1605829113
Medical Sciences
- Open AccessEpigenetic inactivation of the p53-induced long noncoding RNA TP53 target 1 in human cancerAngel Diaz-Lagares, Ana B. Crujeiras, Paula Lopez-Serra, Marta Soler, Fernando Setien, Ashish Goyal, Juan Sandoval, Yutaka Hashimoto, Anna Martinez-Cardús, Antonio Gomez, Holger Heyn, Catia Moutinho, Jesús Espada, August Vidal, Maria Paúles, Maica Galán, Núria Sala, Yoshimitsu Akiyama, María Martínez-Iniesta, Lourdes Farré, Alberto Villanueva, Matthias Gross, Sven Diederichs, Sonia Guil, and Manel EstellerPNAS November 22, 2016 113 (47) E7535-E7544; first published November 7, 2016. https://doi.org/10.1073/pnas.1608585113
- You have accessControl of inflammation by stromal Hedgehog pathway activation restrains colitisJohn J. Lee, Michael E. Rothenberg, E. Scott Seeley, Bryan Zimdahl, Sally Kawano, Wan-Jin Lu, Kunyoo Shin, Tomoyo Sakata-Kato, James K. Chen, Maximilian Diehn, Michael F. Clarke, and Philip A. BeachyPNAS November 22, 2016 113 (47) E7545-E7553; first published November 4, 2016. https://doi.org/10.1073/pnas.1616447113
- You have accessHydrogel films and coatings by swelling-induced gelationDavid Moreau, Caroline Chauvet, François Etienne, François P. Rannou, and Laurent CortéPNAS November 22, 2016 113 (47) 13295-13300; first published November 7, 2016. https://doi.org/10.1073/pnas.1609603113
- Open AccessNicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsiaFeng Li, Tomofumi Fushima, Gen Oyanagi, H. W. Davin Townley-Tilson, Emiko Sato, Hironobu Nakada, Yuji Oe, John R. Hagaman, Jennifer Wilder, Manyu Li, Akiyo Sekimoto, Daisuke Saigusa, Hiroshi Sato, Sadayoshi Ito, J. Charles Jennette, Nobuyo Maeda, S. Ananth Karumanchi, Oliver Smithies, and Nobuyuki TakahashiPNAS November 22, 2016 113 (47) 13450-13455; first published November 7, 2016. https://doi.org/10.1073/pnas.1614947113
- You have accessPreclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancerRoss A. Okimoto, Luping Lin, Victor Olivas, Elton Chan, Evan Markegard, Andrey Rymar, Dana Neel, Xiao Chen, Golzar Hemmati, Gideon Bollag, and Trever G. BivonaPNAS November 22, 2016 113 (47) 13456-13461; first published November 9, 2016. https://doi.org/10.1073/pnas.1610456113
Microbiology
- You have accessGut microbiota induce IGF-1 and promote bone formation and growthJing Yan, Jeremy W. Herzog, Kelly Tsang, Caitlin A. Brennan, Maureen A. Bower, Wendy S. Garrett, Balfour R. Sartor, Antonios O. Aliprantis, and Julia F. CharlesPNAS November 22, 2016 113 (47) E7554-E7563; first published November 7, 2016. https://doi.org/10.1073/pnas.1607235113
- You have accessSiderophore-based immunization strategy to inhibit growth of enteric pathogensMartina Sassone-Corsi, Phoom Chairatana, Tengfei Zheng, Araceli Perez-Lopez, Robert A. Edwards, Michael D. George, Elizabeth M. Nolan, and Manuela RaffatelluPNAS November 22, 2016 113 (47) 13462-13467; first published November 7, 2016. https://doi.org/10.1073/pnas.1606290113
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- Siderophore vaccine protects against UTI- Nov 07, 2016
- You have accessSiderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infectionLaura A. Mike, Sara N. Smith, Christopher A. Sumner, Kathryn A. Eaton, and Harry L. T. MobleyPNAS November 22, 2016 113 (47) 13468-13473; first published November 7, 2016. https://doi.org/10.1073/pnas.1606324113
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- Siderophore-based immunization inhibits pathogens- Nov 07, 2016
Neuroscience
- You have accessRole of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neuronsCarmen R. Sunico, Abdullah Sultan, Tomohiro Nakamura, Nima Dolatabadi, James Parker, Bing Shan, Xuemei Han, John R. Yates III, Eliezer Masliah, Rajesh Ambasudhan, Nobuki Nakanishi, and Stuart A. LiptonPNAS November 22, 2016 113 (47) E7564-E7571; first published November 7, 2016. https://doi.org/10.1073/pnas.1608784113
- You have accessIL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergyBoyi Liu, Yan Tai, Satyanarayana Achanta, Melanie M. Kaelberer, Ana I. Caceres, Xiaomei Shao, Jianqiao Fang, and Sven-Eric JordtPNAS November 22, 2016 113 (47) E7572-E7579; first published November 7, 2016. https://doi.org/10.1073/pnas.1606608113
- You have accessMotor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 mutationsNhat T. T. Le, Lydia Chang, Irina Kovlyagina, Polymnia Georgiou, Nathaniel Safren, Kerstin E. Braunstein, Mark D. Kvarta, Adam M. Van Dyke, Tara A. LeGates, Thomas Philips, Brett M. Morrison, Scott M. Thompson, Adam C. Puche, Todd D. Gould, Jeffrey D. Rothstein, Philip C. Wong, and Mervyn J. MonteiroPNAS November 22, 2016 113 (47) E7580-E7589; first published November 9, 2016. https://doi.org/10.1073/pnas.1608432113
- Open AccessC-terminal domain of mammalian complexin-1 localizes to highly curved membranesJihong Gong, Ying Lai, Xiaohong Li, Mengxian Wang, Jeremy Leitz, Yachong Hu, Yunxiang Zhang, Ucheor B. Choi, Daniel Cipriano, Richard A. Pfuetzner, Thomas C. Südhof, Xiaofei Yang, Axel T. Brunger, and Jiajie DiaoPNAS November 22, 2016 113 (47) E7590-E7599; first published November 7, 2016. https://doi.org/10.1073/pnas.1609917113
- Open AccessReduced high-frequency motor neuron firing, EMG fractionation, and gait variability in awake walking ALS miceMuhamed Hadzipasic, Weiming Ni, Maria Nagy, Natalie Steenrod, Matthew J. McGinley, Adi Kaushal, Eleanor Thomas, David A. McCormick, and Arthur L. HorwichPNAS November 22, 2016 113 (47) E7600-E7609; first published November 7, 2016. https://doi.org/10.1073/pnas.1616832113
- You have accessAutobiographical memory, future imagining, and the medial temporal lobeAdam J. O. Dede, John T. Wixted, Ramona O. Hopkins, and Larry R. SquirePNAS November 22, 2016 113 (47) 13474-13479; first published November 7, 2016. https://doi.org/10.1073/pnas.1615864113
- You have accessLearning and remembering real-world events after medial temporal lobe damageAdam J. O. Dede, Jennifer C. Frascino, John T. Wixted, and Larry R. SquirePNAS November 22, 2016 113 (47) 13480-13485; first published November 7, 2016. https://doi.org/10.1073/pnas.1617025113
- You have accessQuasimodo mediates daily and acute light effects on Drosophila clock neuron excitabilityEdgar Buhl, Adam Bradlaugh, Maite Ogueta, Ko-Fan Chen, Ralf Stanewsky, and James J. L. HodgePNAS November 22, 2016 113 (47) 13486-13491; first published November 7, 2016. https://doi.org/10.1073/pnas.1606547113
- You have accessTemporal coding of reward-guided choice in the posterior parietal cortexDavid J. Hawellek, Yan T. Wong, and Bijan PesaranPNAS November 22, 2016 113 (47) 13492-13497; first published November 7, 2016. https://doi.org/10.1073/pnas.1606479113
- You have accessThe cholinergic forebrain arousal system acts directly on the circadian pacemakerGlenn R. Yamakawa, Priyoneel Basu, Filomeno Cortese, Johanna MacDonnell, Danica Whalley, Victoria M. Smith, and Michael C. AntlePNAS November 22, 2016 113 (47) 13498-13503; first published November 7, 2016. https://doi.org/10.1073/pnas.1610342113
- You have accessDiffusion-weighted imaging uncovers likely sources of processing-speed deficits in schizophreniaPeter Kochunov, Laura M. Rowland, Els Fieremans, Jelle Veraart, Neda Jahanshad, George Eskandar, Xiaoming Du, Florian Muellerklein, Anya Savransky, Dinesh Shukla, Hemalatha Sampath, Paul M. Thompson, and L. Elliot HongPNAS November 22, 2016 113 (47) 13504-13509; first published November 9, 2016. https://doi.org/10.1073/pnas.1608246113
- Open AccessRelationships between cortical myeloarchitecture and electrophysiological networksBenjamin A. E. Hunt, Prejaas K. Tewarie, Olivier E. Mougin, Nicolas Geades, Derek K. Jones, Krish D. Singh, Peter G. Morris, Penny A. Gowland, and Matthew J. BrookesPNAS November 22, 2016 113 (47) 13510-13515; first published November 8, 2016. https://doi.org/10.1073/pnas.1608587113
- Open AccessModel-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2Tetsuya Gotoh, Jae Kyoung Kim, Jingjing Liu, Marian Vila-Caballer, Philip E. Stauffer, John J. Tyson, and Carla V. FinkielsteinPNAS November 22, 2016 113 (47) 13516-13521; first published November 9, 2016. https://doi.org/10.1073/pnas.1607984113
Physiology
- You have accessDecreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfectaArin K. Oestreich, William M. Kamp, Marcus G. McCray, Stephanie M. Carleton, Natalia Karasseva, Kristin L. Lenz, Youngjae Jeong, Salah A. Daghlas, Xiaomei Yao, Yong Wang, Ferris M. Pfeiffer, Mark R. Ellersieck, Laura C. Schulz, and Charlotte L. PhillipsPNAS November 22, 2016 113 (47) 13522-13527; first published November 7, 2016. https://doi.org/10.1073/pnas.1607644113
Plant Biology
- Open AccessIlluminating a plant’s tissue-specific metabolic diversity using computational metabolomics and information theoryDapeng Li, Sven Heiling, Ian T. Baldwin, and Emmanuel GaquerelPNAS November 22, 2016 113 (47) E7610-E7618; first published November 7, 2016. https://doi.org/10.1073/pnas.1610218113
- You have accessThe biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenoriiMaxim Itkin, Rachel Davidovich-Rikanati, Shahar Cohen, Vitaly Portnoy, Adi Doron-Faigenboim, Elad Oren, Shiri Freilich, Galil Tzuri, Nadine Baranes, Shmuel Shen, Marina Petreikov, Rotem Sertchook, Shifra Ben-Dor, Hugo Gottlieb, Alvaro Hernandez, David R. Nelson, Harry S. Paris, Yaakov Tadmor, Yosef Burger, Efraim Lewinsohn, Nurit Katzir, and Arthur SchafferPNAS November 22, 2016 113 (47) E7619-E7628; first published November 7, 2016. https://doi.org/10.1073/pnas.1604828113
- You have accessChloroplast division checkpoint in eukaryotic algaeNobuko Sumiya, Takayuki Fujiwara, Atsuko Era, and Shin-ya MiyagishimaPNAS November 22, 2016 113 (47) E7629-E7638; first published November 11, 2016. https://doi.org/10.1073/pnas.1612872113
Systems Biology
- You have accessEngineering dynamical control of cell fate switching using synthetic phospho-regulonsRussell M. Gordley, Reid E. Williams, Caleb J. Bashor, Jared E. Toettcher, Shude Yan, and Wendell A. LimPNAS November 22, 2016 113 (47) 13528-13533; first published November 7, 2016. https://doi.org/10.1073/pnas.1610973113
Corrections (Online Only)
- You have accessCorrection for Biswas et al., E-cadherin junction formation involves an active kinetic nucleation processPNAS November 22, 2016 113 (47) E7640; first published November 14, 2016. https://doi.org/10.1073/pnas.1617360113
- You have accessCorrection for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motilityPNAS November 22, 2016 113 (47) E7641-E7642; first published November 14, 2016. https://doi.org/10.1073/pnas.1616959113
- You have accessCorrection for Ren et al., LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1PNAS November 22, 2016 113 (47) E7643-E7644; first published November 14, 2016. https://doi.org/10.1073/pnas.1616960113
Commentaries
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