About the Cover

Biological Sciences

• Anthropology

  • You have access

    Regional diversity on the timing for the initial appearance of cereal cultivation and domestication in southwest Asia

    Amaia Arranz-Otaegui, Sue Colledge, Lydia Zapata, Luis Cesar Teira-Mayolini, and Juan José Ibáñez

    PNAS December 6, 2016 113 (49) 14001-14006; first published December 6, 2016. https://doi.org/10.1073/pnas.1612797113

• Applied Biological Sciences

  • You have access

    Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology

    Holly H. Soutter, Paolo Centrella, Matthew A. Clark, John W. Cuozzo, Christoph E. Dumelin, Marie-Aude Guie, Sevan Habeshian, Anthony D. Keefe, Kaitlyn M. Kennedy, Eric A. Sigel, Dawn M. Troast, Ying Zhang, Andrew D. Ferguson, Gareth Davies, Eleanor R. Stead, Jason Breed, Prashanti Madhavapeddi, and Jon A. Read

    PNAS December 6, 2016 113 (49) E7880-E7889; first published November 18, 2016. https://doi.org/10.1073/pnas.1610978113
  • You have access

    Evidence of isotopic fractionation of natural uranium in cultured human cells

    Eduardo Paredes, Emilie Avazeri, Véronique Malard, Claude Vidaud, Pascal E. Reiller, Richard Ortega, Anthony Nonell, Hélène Isnard, Frédéric Chartier, and Carole Bresson

    PNAS December 6, 2016 113 (49) 14007-14012; first published November 21, 2016. https://doi.org/10.1073/pnas.1610885113

• Biochemistry

  • You have access

    Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway

    Yong Xiang, Khanita Karaveg, and Kelley W. Moremen

    PNAS December 6, 2016 113 (49) E7890-E7899; first published November 17, 2016. https://doi.org/10.1073/pnas.1611213113
  • You have access

    Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

    Jessica A. Brown, Charles G. Kinzig, Suzanne J. DeGregorio, and Joan A. Steitz

    PNAS December 6, 2016 113 (49) 14013-14018; first published November 21, 2016. https://doi.org/10.1073/pnas.1614759113
  • You have access

    Characterization of the heterooligomeric red-type rubisco activase from red algae

    Nitin Loganathan, Yi-Chin Candace Tsai, and Oliver Mueller-Cajar

    PNAS December 6, 2016 113 (49) 14019-14024; first published November 21, 2016. https://doi.org/10.1073/pnas.1610758113
  • You have access

    Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids

    Guangtao Li, JiHyun Kim, Zhen Huang, Johnna R. St. Clair, Deborah A. Brown, and Erwin London

    PNAS December 6, 2016 113 (49) 14025-14030; first published November 21, 2016. https://doi.org/10.1073/pnas.1610705113
  • You have access

    Phosphate-binding pocket in Dicer-2 PAZ domain for high-fidelity siRNA production

    Suresh K. Kandasamy and Ryuya Fukunaga

    PNAS December 6, 2016 113 (49) 14031-14036; first published November 21, 2016. https://doi.org/10.1073/pnas.1612393113
  • You have access

    Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

    Yue Hao, Elizabeth Pierce, Daniel Roe, Maho Morita, John A. McIntosh, Vinayak Agarwal, Thomas E. Cheatham III, Eric W. Schmidt, and Satish K. Nair

    PNAS December 6, 2016 113 (49) 14037-14042; first published November 21, 2016. https://doi.org/10.1073/pnas.1609869113

• Biophysics and Computational Biology

  • You have access

    Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

    Matthew S. Hall, Farid Alisafaei, Ehsan Ban, Xinzeng Feng, Chung-Yuen Hui, Vivek B. Shenoy, and Mingming Wu

    PNAS December 6, 2016 113 (49) 14043-14048; first published November 21, 2016. https://doi.org/10.1073/pnas.1613058113
  • You have access

    Atomistic insight into lipid translocation by a TMEM16 scramblase

    Neville P. Bethel and Michael Grabe

    PNAS December 6, 2016 113 (49) 14049-14054; first published November 21, 2016. https://doi.org/10.1073/pnas.1607574113
  • Open Access

    Interactions of divalent cations with calcium binding sites of BK channels reveal independent motions within the gating ring

    Pablo Miranda, Teresa Giraldez, and Miguel Holmgren

    PNAS December 6, 2016 113 (49) 14055-14060; first published November 21, 2016. https://doi.org/10.1073/pnas.1611415113

• Ecology

  • You have access

    Disturbance is the key to plant invasions in cold environments

    Jonas J. Lembrechts, Aníbal Pauchard, Jonathan Lenoir, Martín A. Nuñez, Charly Geron, Arne Ven, Pablo Bravo-Monasterio, Ernesto Teneb, Ivan Nijs, and Ann Milbau

    PNAS December 6, 2016 113 (49) 14061-14066; first published November 21, 2016. https://doi.org/10.1073/pnas.1608980113
  • Open Access

    Long-term aggregation of larval fish siblings during dispersal along an open coast

    Daniel Ottmann, Kirsten Grorud-Colvert, Nicholas M. Sard, Brittany E. Huntington, Michael A. Banks, and Su Sponaugle

    PNAS December 6, 2016 113 (49) 14067-14072; first published November 21, 2016. https://doi.org/10.1073/pnas.1613440113

• Evolution

  • You have access

    Molecular evidence of keratin and melanosomes in feathers of the Early Cretaceous bird Eoconfuciusornis

    Yanhong Pan, Wenxia Zheng, Alison E. Moyer, Jingmai K. O’Connor, Min Wang, Xiaoting Zheng, Xiaoli Wang, Elena R. Schroeter, Zhonghe Zhou, and Mary H. Schweitzer

    PNAS December 6, 2016 113 (49) E7900-E7907; first published November 21, 2016. https://doi.org/10.1073/pnas.1617168113
  • You have access

    Sex and the shifting biodiversity dynamics of marine animals in deep time

    • From the Cover

    Andrew M. Bush, Gene Hunt, and Richard K. Bambach

    PNAS December 6, 2016 113 (49) 14073-14078; first published November 7, 2016. https://doi.org/10.1073/pnas.1610726113

    See companion article:

    • Sexual predators and Mesozoic marine revolution

      - Dec 09, 2016
  • Open Access

    Large numbers of vertebrates began rapid population decline in the late 19th century

    Haipeng Li, Jinggong Xiang-Yu, Guangyi Dai, Zhili Gu, Chen Ming, Zongfeng Yang, Oliver A. Ryder, Wen-Hsiung Li, Yun-Xin Fu, and Ya-Ping Zhang

    PNAS December 6, 2016 113 (49) 14079-14084; first published November 21, 2016. https://doi.org/10.1073/pnas.1616804113
  • You have access

    On the (un)predictability of a large intragenic fitness landscape

    Claudia Bank, Sebastian Matuszewski, Ryan T. Hietpas, and Jeffrey D. Jensen

    PNAS December 6, 2016 113 (49) 14085-14090; first published November 18, 2016. https://doi.org/10.1073/pnas.1612676113
  • You have access

    Transcriptomics and neuroanatomy of the clonal raider ant implicate an expanded clade of odorant receptors in chemical communication

    • From the Cover

    Sean K. McKenzie, Ingrid Fetter-Pruneda, Vanessa Ruta, and Daniel J. C. Kronauer

    PNAS December 6, 2016 113 (49) 14091-14096; first published November 22, 2016. https://doi.org/10.1073/pnas.1610800113

    See companion article:

    • Novel genes for ants' refined smell

      - Nov 28, 2016

• Immunology and Inflammation

  • Open Access

    Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA

    Julio C. C. Lorenzi, Yehuda Z. Cohen, Lillian B. Cohn, Edward F. Kreider, John P. Barton, Gerald H. Learn, Thiago Oliveira, Christy L. Lavine, Joshua A. Horwitz, Allison Settler, Mila Jankovic, Michael S. Seaman, Arup K. Chakraborty, Beatrice H. Hahn, Marina Caskey, and Michel C. Nussenzweig

    PNAS December 6, 2016 113 (49) E7908-E7916; first published November 21, 2016. https://doi.org/10.1073/pnas.1617789113
  • You have access

    The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis

    Yoshitaka Kimura, Asuka Inoue, Sho Hangai, Shinobu Saijo, Hideo Negishi, Junko Nishio, Sho Yamasaki, Yoichiro Iwakura, Hideyuki Yanai, and Tadatsugu Taniguchi

    PNAS December 6, 2016 113 (49) 14097-14102; first published November 21, 2016. https://doi.org/10.1073/pnas.1617903113
  • You have access

    Singular role for T-BET⁺CXCR3⁺ regulatory T cells in protection from autoimmune diabetes

    Tze Guan Tan, Diane Mathis, and Christophe Benoist

    PNAS December 6, 2016 113 (49) 14103-14108; first published November 21, 2016. https://doi.org/10.1073/pnas.1616710113
  • You have access

    Role of the receptor Mas in macrophage-mediated inflammation in vivo

    Anna Hammer, Guang Yang, Juliane Friedrich, Agnes Kovacs, De-Hyung Lee, Katharina Grave, Stefanie Jörg, Natalia Alenina, Janina Grosch, Jürgen Winkler, Ralf Gold, Michael Bader, Arndt Manzel, Lars C. Rump, Dominik N. Müller, Ralf A. Linker, and Johannes Stegbauer

    PNAS December 6, 2016 113 (49) 14109-14114; first published November 21, 2016. https://doi.org/10.1073/pnas.1612668113
  • Open Access

    Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

    Glenn Cruse, Yuzhi Yin, Tomoki Fukuyama, Avanti Desai, Greer K. Arthur, Wolfgang Bäumer, Michael A. Beaven, and Dean D. Metcalfe

    PNAS December 6, 2016 113 (49) 14115-14120; first published November 21, 2016. https://doi.org/10.1073/pnas.1608520113

• Medical Sciences

  • You have access

    MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

    Seung-Ah Yoo, Lin Leng, Bum-Joon Kim, Xin Du, Pathricia V. Tilstam, Kyung Hee Kim, Jin-Sun Kong, Hyung-Ju Yoon, Aihua Liu, Tian Wang, Yan Song, Maor Sauler, Jurgen Bernhagen, Christopher T. Ritchlin, Patty Lee, Chul-Soo Cho, Wan-Uk Kim, and Richard Bucala

    PNAS December 6, 2016 113 (49) E7917-E7926; first published November 21, 2016. https://doi.org/10.1073/pnas.1612717113

• Microbiology

  • You have access

    An oligotrophic deep-subsurface community dependent on syntrophy is dominated by sulfur-driven autotrophic denitrifiers

    Maggie C. Y. Lau, Thomas L. Kieft, Olukayode Kuloyo, Borja Linage-Alvarez, Esta van Heerden, Melody R. Lindsay, Cara Magnabosco, Wei Wang, Jessica B. Wiggins, Ling Guo, David H. Perlman, Saw Kyin, Henry H. Shwe, Rachel L. Harris, Youmi Oh, Min Joo Yi, Roland Purtschert, Greg F. Slater, Shuhei Ono, Siwen Wei, Long Li, Barbara Sherwood Lollar, and Tullis C. Onstott

    PNAS December 6, 2016 113 (49) E7927-E7936; first published November 21, 2016. https://doi.org/10.1073/pnas.1612244113

    See companion article:

    • Bacteria work together to survive Earth’s depths

      - Jan 31, 2017
  • Open Access

    Proteomics and comparative genomics of Nitrososphaera viennensis reveal the core genome and adaptations of archaeal ammonia oxidizers

    Melina Kerou, Pierre Offre, Luis Valledor, Sophie S. Abby, Michael Melcher, Matthias Nagler, Wolfram Weckwerth, and Christa Schleper

    PNAS December 6, 2016 113 (49) E7937-E7946; first published November 18, 2016. https://doi.org/10.1073/pnas.1601212113
  • Open Access

    Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK

    Tania J. Lupoli, Allison Fay, Carolina Adura, Michael S. Glickman, and Carl F. Nathan

    PNAS December 6, 2016 113 (49) E7947-E7956; first published November 21, 2016. https://doi.org/10.1073/pnas.1617644113
  • You have access

    Epstein–Barr virus super-enhancer eRNAs are essential for MYC oncogene expression and lymphoblast proliferation

    Jun Liang, Hufeng Zhou, Catherine Gerdt, Min Tan, Tyler Colson, Kenneth M. Kaye, Elliott Kieff, and Bo Zhao

    PNAS December 6, 2016 113 (49) 14121-14126; first published November 18, 2016. https://doi.org/10.1073/pnas.1616697113
  • You have access

    Genomic sequencing-based mutational enrichment analysis identifies motility genes in a genetically intractable gut microbe

    Sena Bae, Olaf Mueller, Sandi Wong, John F. Rawls, and Raphael H. Valdivia

    PNAS December 6, 2016 113 (49) 14127-14132; first published November 23, 2016. https://doi.org/10.1073/pnas.1612753113

• Neuroscience

  • You have access

    Context-dependent memory traces in the crab’s mushroom bodies: Functional support for a common origin of high-order memory centers

    Francisco Javier Maza, Julieta Sztarker, Avishag Shkedy, Valeria Natacha Peszano, Fernando Federico Locatelli, and Alejandro Delorenzi

    PNAS December 6, 2016 113 (49) E7957-E7965; first published November 16, 2016. https://doi.org/10.1073/pnas.1612418113
  • You have access

    Emergence of an abstract categorical code enabling the discrimination of temporally structured tactile stimuli

    Román Rossi-Pool, Emilio Salinas, Antonio Zainos, Manuel Alvarez, José Vergara, Néstor Parga, and Ranulfo Romo

    PNAS December 6, 2016 113 (49) E7966-E7975; first published November 21, 2016. https://doi.org/10.1073/pnas.1618196113
  • Open Access

    Optical magnetic detection of single-neuron action potentials using quantum defects in diamond

    John F. Barry, Matthew J. Turner, Jennifer M. Schloss, David R. Glenn, Yuyu Song, Mikhail D. Lukin, Hongkun Park, and Ronald L. Walsworth

    PNAS December 6, 2016 113 (49) 14133-14138; first published November 22, 2016. https://doi.org/10.1073/pnas.1601513113
  • Open Access

    Rapid recovery from the effects of early monocular deprivation is enabled by temporary inactivation of the retinas

    Ming-fai Fong, Donald E. Mitchell, Kevin R. Duffy, and Mark F. Bear

    PNAS December 6, 2016 113 (49) 14139-14144; first published November 17, 2016. https://doi.org/10.1073/pnas.1613279113

• Pharmacology

  • You have access

    Loss of β-adrenergic–stimulated phosphorylation of Ca_V1.2 channels on Ser1700 leads to heart failure

    Linghai Yang, Dao-Fu Dai, Can Yuan, Ruth E. Westenbroek, Haijie Yu, Nastassya West, Horacio O. de la Iglesia, and William A. Catterall

    PNAS December 6, 2016 113 (49) E7976-E7985; first published November 18, 2016. https://doi.org/10.1073/pnas.1617116113

• Physiology

  • You have access

    Mechanism of gating by calcium in connexin hemichannels

    William Lopez, Jayalakshmi Ramachandran, Abdelaziz Alsamarah, Yun Luo, Andrew L. Harris, and Jorge E. Contreras

    PNAS December 6, 2016 113 (49) E7986-E7995; first published November 21, 2016. https://doi.org/10.1073/pnas.1609378113

• Plant Biology

  • Open Access

    Root nodule symbiosis in Lotus japonicus drives the establishment of distinctive rhizosphere, root, and nodule bacterial communities

    Rafal Zgadzaj, Ruben Garrido-Oter, Dorthe Bodker Jensen, Anna Koprivova, Paul Schulze-Lefert, and Simona Radutoiu

    PNAS December 6, 2016 113 (49) E7996-E8005; first published November 18, 2016. https://doi.org/10.1073/pnas.1616564113
  • Open Access

    Construction of a male sterility system for hybrid rice breeding and seed production using a nuclear male sterility gene

    Zhenyi Chang, Zhufeng Chen, Na Wang, Gang Xie, Jiawei Lu, Wei Yan, Junli Zhou, Xiaoyan Tang, and Xing Wang Deng

    PNAS December 6, 2016 113 (49) 14145-14150; first published November 18, 2016. https://doi.org/10.1073/pnas.1613792113
  • Open Access

    The earliest maize from San Marcos Tehuacán is a partial domesticate with genomic evidence of inbreeding

    Miguel Vallebueno-Estrada, Isaac Rodríguez-Arévalo, Alejandra Rougon-Cardoso, Javier Martínez González, Angel García Cook, Rafael Montiel, and Jean-Philippe Vielle-Calzada

    PNAS December 6, 2016 113 (49) 14151-14156; first published November 21, 2016. https://doi.org/10.1073/pnas.1609701113
  • Open Access

    Cytoskeleton dynamics control the first asymmetric cell division in Arabidopsis zygote

    • From the Cover

    Yusuke Kimata, Takumi Higaki, Tomokazu Kawashima, Daisuke Kurihara, Yoshikatsu Sato, Tomomi Yamada, Seiichiro Hasezawa, Frederic Berger, Tetsuya Higashiyama, and Minako Ueda

    PNAS December 6, 2016 113 (49) 14157-14162; first published November 22, 2016. https://doi.org/10.1073/pnas.1613979113

• Systems Biology

  • You have access

    Mechanical bounds to transcriptional noise

    Stuart A. Sevier, David A. Kessler, and Herbert Levine

    PNAS December 6, 2016 113 (49) 13983-13988; first published November 22, 2016. https://doi.org/10.1073/pnas.1612651113