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Table of Contents
March 01, 2016; vol. 113 no. 9
This Week in PNAS
Letters (Online Only)
- You have accessConstrained positive selection on cancer mutations in normal skinIñigo Martincorena, Philip H. Jones, and Peter J. CampbellPNAS March 1, 2016 113 (9) E1128-E1129; first published February 16, 2016. https://doi.org/10.1073/pnas.1600910113
- You have accessReply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lackingBenjamin D. SimonsPNAS March 1, 2016 113 (9) E1130-E1131; first published February 16, 2016. https://doi.org/10.1073/pnas.1601045113
See companion article:
- DNA sequencing as a probe of human stem cell fate- Dec 22, 2015
- You have accessOn Bayesian inference about extinctionAndrew R. SolowPNAS March 1, 2016 113 (9) E1132; first published February 16, 2016. https://doi.org/10.1073/pnas.1525317113
- You have accessReply to Solow: Sense and nonsense in the choice of extinction priorsJohn AlroyPNAS March 1, 2016 113 (9) E1133; first published February 16, 2016. https://doi.org/10.1073/pnas.1600387113
See companion article:
- Extinction rates of reptiles and amphibians- Oct 05, 2015
Opinion
Leading scientists discuss current issues.
PNAS Plus Significance Statements
Brief statements written by the authors about the significance of their papers.
Physical Sciences
Applied Physical Sciences
- Open AccessGiant magneto-optical Raman effect in a layered transition metal compoundJianting Ji, Anmin Zhang, Jiahe Fan, Yuesheng Li, Xiaoqun Wang, Jiandi Zhang, E. W. Plummer, and Qingming ZhangPNAS March 1, 2016 113 (9) 2349-2353; first published February 16, 2016. https://doi.org/10.1073/pnas.1601010113
Chemistry
- You have accessBioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranesQi Xiao, Srujana S. Yadavalli, Shaodong Zhang, Samuel E. Sherman, Elodie Fiorin, Louise da Silva, Daniela A. Wilson, Daniel A. Hammer, Sabine André, Hans-Joachim Gabius, Michael L. Klein, Mark Goulian, and Virgil PercecPNAS March 1, 2016 113 (9) E1134-E1141; first published February 16, 2016. https://doi.org/10.1073/pnas.1525589113
- Open AccessCholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cellsSalah Mansour, Anna S. Tocheva, Chris Cave-Ayland, Moritz M. Machelett, Barbara Sander, Nikolai M. Lissin, Peter E. Molloy, Mark S. Baird, Gunthard Stübs, Nicolas W. J. Schröder, Ralf R. Schumann, Jörg Rademann, Anthony D. Postle, Bent K. Jakobsen, Ben G. Marshall, Rajendra Gosain, Paul T. Elkington, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Ivo Tews, and Stephan D. GadolaPNAS March 1, 2016 113 (9) E1266-E1275; first published February 16, 2016. https://doi.org/10.1073/pnas.1519246113
Earth, Atmospheric, and Planetary Sciences
- Open AccessWidespread collapse of the Ross Ice Shelf during the late HoloceneYusuke Yokoyama, John B. Anderson, Masako Yamane, Lauren M. Simkins, Yosuke Miyairi, Takahiro Yamazaki, Mamito Koizumi, Hisami Suga, Kazuya Kusahara, Lindsay Prothro, Hiroyasu Hasumi, John R. Southon, and Naohiko OhkouchiPNAS March 1, 2016 113 (9) 2354-2359; first published February 16, 2016. https://doi.org/10.1073/pnas.1516908113
- Open AccessMarine anoxia and delayed Earth system recovery after the end-Permian extinctionKimberly V. Lau, Kate Maher, Demir Altiner, Brian M. Kelley, Lee R. Kump, Daniel J. Lehrmann, Juan Carlos Silva-Tamayo, Karrie L. Weaver, Meiyi Yu, and Jonathan L. PaynePNAS March 1, 2016 113 (9) 2360-2365; first published February 16, 2016. https://doi.org/10.1073/pnas.1515080113
Engineering
- You have accessTailoring nanoparticle designs to target cancer based on tumor pathophysiologyEdward A. Sykes, Qin Dai, Christopher D. Sarsons, Juan Chen, Jonathan V. Rocheleau, David M. Hwang, Gang Zheng, David T. Cramb, Kristina D. Rinker, and Warren C. W. ChanPNAS March 1, 2016 113 (9) E1142-E1151; first published February 16, 2016. https://doi.org/10.1073/pnas.1521265113
- Open AccessAAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreasTracey L. Smith, Ziqiang Yuan, Marina Cardó-Vila, Carmen Sanchez Claros, Asha Adem, Min-Hui Cui, Craig A. Branch, Juri G. Gelovani, Steven K. Libutti, Richard L. Sidman, Renata Pasqualini, and Wadih ArapPNAS March 1, 2016 113 (9) 2466-2471; first published February 16, 2016. https://doi.org/10.1073/pnas.1525709113
Environmental Sciences
- You have accessDelayed fungal evolution did not cause the Paleozoic peak in coal production
- From the Cover
Matthew P. Nelsen, William A. DiMichele, Shanan E. Peters, and C. Kevin BoycePNAS March 1, 2016 113 (9) 2442-2447; first published January 19, 2016. https://doi.org/10.1073/pnas.1517943113See companion article:
- A Late Paleozoic climate window of opportunity- Feb 16, 2016
Physics
- You have accessCrossover from metal to insulator in dense lithium-rich compound CLi4Xilian Jin, Xiao-Jia Chen, Tian Cui, Ho-kwang Mao, Huadi Zhang, Quan Zhuang, Kuo Bao, Dawei Zhou, Bingbing Liu, Qiang Zhou, and Zhi HePNAS March 1, 2016 113 (9) 2366-2369; first published February 16, 2016. https://doi.org/10.1073/pnas.1525412113
Social Sciences
Psychological and Cognitive Sciences
- Open AccessCortical response to categorical color perception in infants investigated by near-infrared spectroscopyJiale Yang, So Kanazawa, Masami K. Yamaguchi, and Ichiro KurikiPNAS March 1, 2016 113 (9) 2370-2375; first published February 8, 2016. https://doi.org/10.1073/pnas.1512044113
- Open AccessInfants use relative numerical group size to infer social dominanceAnthea Pun, Susan A. J. Birch, and Andrew Scott BaronPNAS March 1, 2016 113 (9) 2376-2381; first published February 16, 2016. https://doi.org/10.1073/pnas.1514879113
Sustainability Science
- You have accessMeasuring the value of groundwater and other forms of natural capitalEli P. Fenichel, Joshua K. Abbott, Jude Bayham, Whitney Boone, Erin M. K. Haacker, and Lisa PfeifferPNAS March 1, 2016 113 (9) 2382-2387; first published February 8, 2016. https://doi.org/10.1073/pnas.1513779113
Biological Sciences
Applied Biological Sciences
- Open AccessGenetically encoded sensors enable real-time observation of metabolite productionJameson K. Rogers and George M. ChurchPNAS March 1, 2016 113 (9) 2388-2393; first published February 8, 2016. https://doi.org/10.1073/pnas.1600375113
Biochemistry
- You have accessBioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranesQi Xiao, Srujana S. Yadavalli, Shaodong Zhang, Samuel E. Sherman, Elodie Fiorin, Louise da Silva, Daniela A. Wilson, Daniel A. Hammer, Sabine André, Hans-Joachim Gabius, Michael L. Klein, Mark Goulian, and Virgil PercecPNAS March 1, 2016 113 (9) E1134-E1141; first published February 16, 2016. https://doi.org/10.1073/pnas.1525589113
- You have accessCharacterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTRLoes M. Stevers, Chan V. Lam, Seppe F. R. Leysen, Femke A. Meijer, Daphne S. van Scheppingen, Rens M. J. M. de Vries, Graeme W. Carlile, Lech G. Milroy, David Y. Thomas, Luc Brunsveld, and Christian OttmannPNAS March 1, 2016 113 (9) E1152-E1161; first published February 17, 2016. https://doi.org/10.1073/pnas.1516631113
- Open AccessCalcium can mobilize and activate myosin-VI
- From the Cover
Christopher Batters, Dario Brack, Heike Ellrich, Beate Averbeck, and Claudia VeigelPNAS March 1, 2016 113 (9) E1162-E1169; first published January 25, 2016. https://doi.org/10.1073/pnas.1519435113See companion article:
- Calcium gets myosin VI ready for work- Feb 19, 2016
- Open AccessSingle-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteinsLogan R. Myler, Ignacio F. Gallardo, Yi Zhou, Fade Gong, Soo-Hyun Yang, Marc S. Wold, Kyle M. Miller, Tanya T. Paull, and Ilya J. FinkelsteinPNAS March 1, 2016 113 (9) E1170-E1179; first published February 16, 2016. https://doi.org/10.1073/pnas.1516674113
- Open Access70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteriaHiroshi Yamamoto, Daniela Wittek, Romi Gupta, Bo Qin, Takuya Ueda, Roland Krause, Kaori Yamamoto, Renate Albrecht, Markus Pech, and Knud H. NierhausPNAS March 1, 2016 113 (9) E1180-E1189; first published February 17, 2016. https://doi.org/10.1073/pnas.1524554113
- You have accessMechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion proteinYu Chen, Ravin Seepersaud, Barbara A. Bensing, Paul M. Sullam, and Tom A. RapoportPNAS March 1, 2016 113 (9) E1190-E1199; first published February 16, 2016. https://doi.org/10.1073/pnas.1600494113
- You have accessFirst structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramerEmilia C. Arturo, Kushol Gupta, Annie Héroux, Linda Stith, Penelope J. Cross, Emily J. Parker, Patrick J. Loll, and Eileen K. JaffePNAS March 1, 2016 113 (9) 2394-2399; first published February 16, 2016. https://doi.org/10.1073/pnas.1516967113
- You have accessA protein constructed de novo enables cell growth by altering gene regulationKatherine M. Digianantonio and Michael H. HechtPNAS March 1, 2016 113 (9) 2400-2405; first published February 16, 2016. https://doi.org/10.1073/pnas.1600566113
Biophysics and Computational Biology
- Open AccessNovel actin filaments from Bacillus thuringiensis form nanotubules for plasmid DNA segregationShimin Jiang, Akihiro Narita, David Popp, Umesh Ghoshdastider, Lin Jie Lee, Ramanujam Srinivasan, Mohan K. Balasubramanian, Toshiro Oda, Fujiet Koh, Mårten Larsson, and Robert C. RobinsonPNAS March 1, 2016 113 (9) E1200-E1205; first published February 12, 2016. https://doi.org/10.1073/pnas.1600129113
- You have accessKinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreadingMarija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, Kristina A. Ganzinger, Andrey Y. Abramov, Sonia Gandhi, Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, and David KlenermanPNAS March 1, 2016 113 (9) E1206-E1215; first published February 16, 2016. https://doi.org/10.1073/pnas.1524128113
- You have accessConserved properties of individual Ca2+-binding sites in calmodulinD. Brent Halling, Benjamin J. Liebeskind, Amelia W. Hall, and Richard W. AldrichPNAS March 1, 2016 113 (9) E1216-E1225; first published February 16, 2016. https://doi.org/10.1073/pnas.1600385113
- You have accessEnzyme catalysis by entropy without Circe effect
- From the Cover
Masoud Kazemi, Fahmi Himo, and Johan ÅqvistPNAS March 1, 2016 113 (9) 2406-2411; first published January 11, 2016. https://doi.org/10.1073/pnas.1521020113See companion article:
- Dispelling Circe's effect in enzyme catalysis- Feb 16, 2016
- You have accessLoad-dependent destabilization of the γ-rotor shaft in FOF1 ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometrySiavash Vahidi, Yumin Bi, Stanley D. Dunn, and Lars KonermannPNAS March 1, 2016 113 (9) 2412-2417; first published February 16, 2016. https://doi.org/10.1073/pnas.1520464113
Cell Biology
- You have accessMEKK2 mediates an alternative β-catenin pathway that promotes bone formationMatthew Blake Greenblatt, Dong Yeon Shin, Hwanhee Oh, Ki-Young Lee, Bo Zhai, Steven P. Gygi, Sutada Lotinun, Roland Baron, Dou Liu, Bing Su, Laurie H. Glimcher, and Jae-Hyuck ShimPNAS March 1, 2016 113 (9) E1226-E1235; first published February 16, 2016. https://doi.org/10.1073/pnas.1600813113
- You have accessThe light chains of kinesin-1 are autoinhibitedYan Y. Yip, Stefano Pernigo, Anneri Sanger, Mengjia Xu, Maddy Parsons, Roberto A. Steiner, and Mark P. DoddingPNAS March 1, 2016 113 (9) 2418-2423; first published February 16, 2016. https://doi.org/10.1073/pnas.1520817113
- Open AccessDynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cellsHakan Cakmak, Federica Franciosi, A. Musa Zamah, Marcelle I. Cedars, and Marco ContiPNAS March 1, 2016 113 (9) 2424-2429; first published February 10, 2016. https://doi.org/10.1073/pnas.1519990113
Environmental Sciences
- You have accessOyster reproduction is affected by exposure to polystyrene microplastics
- From the Cover
Rossana Sussarellu, Marc Suquet, Yoann Thomas, Christophe Lambert, Caroline Fabioux, Marie Eve Julie Pernet, Nelly Le Goïc, Virgile Quillien, Christian Mingant, Yanouk Epelboin, Charlotte Corporeau, Julien Guyomarch, Johan Robbens, Ika Paul-Pont, Philippe Soudant, and Arnaud HuvetPNAS March 1, 2016 113 (9) 2430-2435; first published February 1, 2016. https://doi.org/10.1073/pnas.1519019113See companion article:
- Marine microplastics affect future generations- Feb 22, 2016
See companion article:
- Realistic scenario for microplastic impact studies- Jul 12, 2016
- Open AccessIlluminating structural proteins in viral “dark matter” with metaproteomicsJennifer R. Brum, J. Cesar Ignacio-Espinoza, Eun-Hae Kim, Gareth Trubl, Robert M. Jones, Simon Roux, Nathan C. VerBerkmoes, Virginia I. Rich, and Matthew B. SullivanPNAS March 1, 2016 113 (9) 2436-2441; first published February 16, 2016. https://doi.org/10.1073/pnas.1525139113
Evolution
- You have accessDelayed fungal evolution did not cause the Paleozoic peak in coal production
- From the Cover
Matthew P. Nelsen, William A. DiMichele, Shanan E. Peters, and C. Kevin BoycePNAS March 1, 2016 113 (9) 2442-2447; first published January 19, 2016. https://doi.org/10.1073/pnas.1517943113See companion article:
- A Late Paleozoic climate window of opportunity- Feb 16, 2016
- You have accessCompetition between anthocyanin and flavonol biosynthesis produces spatial pattern variation of floral pigments between Mimulus speciesYao-Wu Yuan, Alexandra B. Rebocho, Janelle M. Sagawa, Lauren E. Stanley, and Harvey D. Bradshaw Jr.PNAS March 1, 2016 113 (9) 2448-2453; first published February 16, 2016. https://doi.org/10.1073/pnas.1515294113
Genetics
- You have accessDeep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defectHiva Fassihi, Mieran Sethi, Heather Fawcett, Jonathan Wing, Natalie Chandler, Shehla Mohammed, Emma Craythorne, Ana M. S. Morley, Rongxuan Lim, Sally Turner, Tanya Henshaw, Isabel Garrood, Paola Giunti, Tammy Hedderly, Adesoji Abiona, Harsha Naik, Gemma Harrop, David McGibbon, Nicolaas G. J. Jaspers, Elena Botta, Tiziana Nardo, Miria Stefanini, Antony R. Young, Robert P. E. Sarkany, and Alan R. LehmannPNAS March 1, 2016 113 (9) E1236-E1245; first published February 16, 2016. https://doi.org/10.1073/pnas.1519444113
- You have accessPhagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovaryAllison K. Timmons, Albert A. Mondragon, Claire E. Schenkel, Alla Yalonetskaya, Jeffrey D. Taylor, Katherine E. Moynihan, Jon Iker Etchegaray, Tracy L. Meehan, and Kimberly McCallPNAS March 1, 2016 113 (9) E1246-E1255; first published February 16, 2016. https://doi.org/10.1073/pnas.1522830113
- Open AccessSex-specific regulation of Lgr3 in Drosophila neuronsGeoffrey W. Meissner, Shengzhan D. Luo, Brian G. Dias, Michael J. Texada, and Bruce S. BakerPNAS March 1, 2016 113 (9) E1256-E1265; first published February 16, 2016. https://doi.org/10.1073/pnas.1600241113
- Open AccessVisualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testesGeoffrey J. Maher, Simon J. McGowan, Eleni Giannoulatou, Clare Verrill, Anne Goriely, and Andrew O. M. WilkiePNAS March 1, 2016 113 (9) 2454-2459; first published February 8, 2016. https://doi.org/10.1073/pnas.1521325113
Immunology and Inflammation
- Open AccessCholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cellsSalah Mansour, Anna S. Tocheva, Chris Cave-Ayland, Moritz M. Machelett, Barbara Sander, Nikolai M. Lissin, Peter E. Molloy, Mark S. Baird, Gunthard Stübs, Nicolas W. J. Schröder, Ralf R. Schumann, Jörg Rademann, Anthony D. Postle, Bent K. Jakobsen, Ben G. Marshall, Rajendra Gosain, Paul T. Elkington, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Ivo Tews, and Stephan D. GadolaPNAS March 1, 2016 113 (9) E1266-E1275; first published February 16, 2016. https://doi.org/10.1073/pnas.1519246113
- You have accessHow structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoireSydney J. Blevins, Brian G. Pierce, Nishant K. Singh, Timothy P. Riley, Yuan Wang, Timothy T. Spear, Michael I. Nishimura, Zhiping Weng, and Brian M. BakerPNAS March 1, 2016 113 (9) E1276-E1285; first published February 16, 2016. https://doi.org/10.1073/pnas.1522069113
- You have accessSuccessful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsetsJohn F. Ryan, Rachel Hovde, Jacob Glanville, Shu-Chen Lyu, Xuhuai Ji, Sheena Gupta, Robert J. Tibshirani, David C. Jay, Scott D. Boyd, R. Sharon Chinthrajah, Mark M. Davis, Stephen J. Galli, Holden T. Maecker, and Kari C. NadeauPNAS March 1, 2016 113 (9) E1286-E1295; first published January 25, 2016. https://doi.org/10.1073/pnas.1520180113
- Open AccessCD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicityKazuyuki Akane, Seiji Kojima, Tak W. Mak, Hiroshi Shiku, and Haruhiko SuzukiPNAS March 1, 2016 113 (9) 2460-2465; first published February 11, 2016. https://doi.org/10.1073/pnas.1525098113
Medical Sciences
- You have accessTruncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanomaYonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, and Lynda ChinPNAS March 1, 2016 113 (9) E1296-E1305; first published February 16, 2016. https://doi.org/10.1073/pnas.1513801113
- Open AccessAAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreasTracey L. Smith, Ziqiang Yuan, Marina Cardó-Vila, Carmen Sanchez Claros, Asha Adem, Min-Hui Cui, Craig A. Branch, Juri G. Gelovani, Steven K. Libutti, Richard L. Sidman, Renata Pasqualini, and Wadih ArapPNAS March 1, 2016 113 (9) 2466-2471; first published February 16, 2016. https://doi.org/10.1073/pnas.1525709113
- You have accessGene control of tyrosine kinase TIE2 and vascular manifestations of infectionsChandra C. Ghosh, Sascha David, Ruyang Zhang, Anthony Berghelli, Katelyn Milam, Sarah J. Higgins, Jon Hunter, Aditi Mukherjee, Yongyue Wei, Mei Tran, Freeman Suber, Lester Kobzik, Kevin C. Kain, Shulin Lu, Ansgar Santel, Kiichiro Yano, Prajna Guha, Daniel J. Dumont, David C. Christiani, and Samir M. ParikhPNAS March 1, 2016 113 (9) 2472-2477; first published February 16, 2016. https://doi.org/10.1073/pnas.1519467113
Microbiology
- You have accessProbiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in miceJun Li, Cecilia Ying Ju Sung, Nikki Lee, Yueqiong Ni, Jussi Pihlajamäki, Gianni Panagiotou, and Hani El-NezamiPNAS March 1, 2016 113 (9) E1306-E1315; first published February 16, 2016. https://doi.org/10.1073/pnas.1518189113
- You have accessDifferential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor
- Inaugural Article
Umesh Ahuja, Bhumika Shokeen, Ning Cheng, Yeonjoo Cho, Charles Blum, Giovanni Coppola, and Jeff F. MillerPNAS March 1, 2016 113 (9) 2341-2348; first published February 16, 2016. https://doi.org/10.1073/pnas.1600320113 - You have accessA virus of hyperthermophilic archaea with a unique architecture among DNA virusesElena Ilka Rensen, Tomohiro Mochizuki, Emmanuelle Quemin, Stefan Schouten, Mart Krupovic, and David PrangishviliPNAS March 1, 2016 113 (9) 2478-2483; first published February 16, 2016. https://doi.org/10.1073/pnas.1518929113
- You have accessProteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesisMarion Lussignol, Martina Kopp, Kelly Molloy, Gema Vizcay-Barrena, Roland A. Fleck, Marcus Dorner, Kierstin L. Bell, Brian T. Chait, Charles M. Rice, and Maria Teresa CatanesePNAS March 1, 2016 113 (9) 2484-2489; first published February 16, 2016. https://doi.org/10.1073/pnas.1518934113
- You have accessCnaA domains in bacterial pili are efficient dissipaters of large mechanical shocksDaniel J. Echelman, Jorge Alegre-Cebollada, Carmen L. Badilla, Chungyu Chang, Hung Ton-That, and Julio M. FernándezPNAS March 1, 2016 113 (9) 2490-2495; first published February 16, 2016. https://doi.org/10.1073/pnas.1522946113
- Open AccessThe archaeal Ced system imports DNAMarleen van Wolferen, Alexander Wagner, Chris van der Does, and Sonja-Verena AlbersPNAS March 1, 2016 113 (9) 2496-2501; first published February 16, 2016. https://doi.org/10.1073/pnas.1513740113
- Open AccessA highly precise and portable genome engineering method allows comparison of mutational effects across bacterial speciesÁkos Nyerges, Bálint Csörgő, István Nagy, Balázs Bálint, Péter Bihari, Viktória Lázár, Gábor Apjok, Kinga Umenhoffer, Balázs Bogos, György Pósfai, and Csaba PálPNAS March 1, 2016 113 (9) 2502-2507; first published February 16, 2016. https://doi.org/10.1073/pnas.1520040113
Neuroscience
- Open AccessThe adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial functionSamuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, and Mathew Blurton-JonesPNAS March 1, 2016 113 (9) E1316-E1325; first published February 16, 2016. https://doi.org/10.1073/pnas.1525466113
- You have accessMidbrain auditory selectivity to natural soundsMelville J. Wohlgemuth and Cynthia F. MossPNAS March 1, 2016 113 (9) 2508-2513; first published February 16, 2016. https://doi.org/10.1073/pnas.1517451113
- You have accessTargeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration
- From the Cover
Drew L. Sellers, Jamie M. Bergen, Russell N. Johnson, Heidi Back, John M. Ravits, Philip J. Horner, and Suzie H. PunPNAS March 1, 2016 113 (9) 2514-2519; first published February 17, 2016. https://doi.org/10.1073/pnas.1515526113 - Open AccessConsumption of palatable food primes food approach behavior by rapidly increasing synaptic density in the VTAShuai Liu, Andrea K. Globa, Fergil Mills, Lindsay Naef, Min Qiao, Shernaz X. Bamji, and Stephanie L. BorglandPNAS March 1, 2016 113 (9) 2520-2525; first published February 16, 2016. https://doi.org/10.1073/pnas.1515724113
Plant Biology
- You have accessProbing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesisSibongile Mafu, Meirong Jia, Jiachen Zi, Dana Morrone, Yisheng Wu, Meimei Xu, Matthew L. Hillwig, and Reuben J. PetersPNAS March 1, 2016 113 (9) 2526-2531; first published February 16, 2016. https://doi.org/10.1073/pnas.1512096113
Psychological and Cognitive Sciences
- You have accessBrain size predicts problem-solving ability in mammalian carnivoresSarah Benson-Amram, Ben Dantzer, Gregory Stricker, Eli M. Swanson, and Kay E. HolekampPNAS March 1, 2016 113 (9) 2532-2537; first published January 25, 2016. https://doi.org/10.1073/pnas.1505913113
- Open AccessSlow dissolving of emotional distress contributes to hyperarousalRick Wassing, Jeroen S. Benjamins, Kim Dekker, Sarah Moens, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Sophie van der Sluis, Ysbrand D. Van Der Werf, Lucia M. Talamini, Matthew P. Walker, Frans Schalkwijk, and Eus J. W. Van SomerenPNAS March 1, 2016 113 (9) 2538-2543; first published February 8, 2016. https://doi.org/10.1073/pnas.1522520113
Systems Biology
- Open AccessMultiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEMAlan S. L. Wong, Gigi C. G. Choi, Cheryl H. Cui, Gabriela Pregernig, Pamela Milani, Miriam Adam, Samuel D. Perli, Samuel W. Kazer, Aleth Gaillard, Mario Hermann, Alex K. Shalek, Ernest Fraenkel, and Timothy K. LuPNAS March 1, 2016 113 (9) 2544-2549; first published February 10, 2016. https://doi.org/10.1073/pnas.1517883113
Corrections (Online Only)
- You have accessCorrection for Strickland et al., Event representations constrain the structure of language: Sign language as a window into universally accessible linguistic biasesPNAS March 1, 2016 113 (9) E1326; first published February 16, 2016. https://doi.org/10.1073/pnas.1600619113
- You have accessCorrection for Upadhyay et al., Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brainPNAS March 1, 2016 113 (9) E1327; first published February 16, 2016. https://doi.org/10.1073/pnas.1600771113
- You have accessCorrection for Kumar et al., Natural history-driven, plant-mediated RNAi-based study reveals CYP6B46’s role in a nicotine-mediated antipredator herbivore defensePNAS March 1, 2016 113 (9) E1328; first published February 16, 2016. https://doi.org/10.1073/pnas.1600609113
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