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Table of Contents

March 01, 2016; vol. 113 no. 9

This Week in PNAS

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    In This Issue
    PNAS March 1, 2016 113 (9) 2319-2321; https://doi.org/10.1073/iti0916113

Letters (Online Only)

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    Constrained positive selection on cancer mutations in normal skin
    Iñigo Martincorena, Philip H. Jones, and Peter J. Campbell
    PNAS March 1, 2016 113 (9) E1128-E1129; first published February 16, 2016. https://doi.org/10.1073/pnas.1600910113
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    Reply to Martincorena et al.: Evidence for constrained positive selection of cancer mutations in normal skin is lacking
    Benjamin D. Simons
    PNAS March 1, 2016 113 (9) E1130-E1131; first published February 16, 2016. https://doi.org/10.1073/pnas.1601045113

    See companion article:

    • DNA sequencing as a probe of human stem cell fate
      - Dec 22, 2015
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    On Bayesian inference about extinction
    Andrew R. Solow
    PNAS March 1, 2016 113 (9) E1132; first published February 16, 2016. https://doi.org/10.1073/pnas.1525317113
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    Reply to Solow: Sense and nonsense in the choice of extinction priors
    John Alroy
    PNAS March 1, 2016 113 (9) E1133; first published February 16, 2016. https://doi.org/10.1073/pnas.1600387113

    See companion article:

    • Extinction rates of reptiles and amphibians
      - Oct 05, 2015

Opinion

Leading scientists discuss current issues.
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    Opinion: Climate policy needs more than muddling
    • Front Matter
    M. Granger Morgan
    PNAS March 1, 2016 113 (9) 2322-2324; https://doi.org/10.1073/pnas.1601167113

Commentaries

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    Calcium gets myosin VI ready for work
    Thomas A. Masters, John Kendrick-Jones, and Folma Buss
    PNAS March 1, 2016 113 (9) 2325-2327; first published February 19, 2016. https://doi.org/10.1073/pnas.1600725113

    See companion article:

    • Calcium can mobilize and activate myosin-VI
      - Jan 25, 2016
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    Dispelling the effects of a sorceress in enzyme catalysis
    Adrian J. Mulholland
    PNAS March 1, 2016 113 (9) 2328-2330; first published February 16, 2016. https://doi.org/10.1073/pnas.1601276113

    See companion article:

    • Enzyme catalysis and entropy
      - Jan 11, 2016
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    Marine microplastics spell big problems for future generations
    Tamara S. Galloway and Ceri N. Lewis
    PNAS March 1, 2016 113 (9) 2331-2333; first published February 22, 2016. https://doi.org/10.1073/pnas.1600715113

    See companion article:

    • Microplastics affect oyster reproduction
      - Feb 01, 2016
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    A Late Paleozoic climate window of opportunity
    Isabel Patricia Montañez
    PNAS March 1, 2016 113 (9) 2334-2336; first published February 16, 2016. https://doi.org/10.1073/pnas.1600236113

    See companion article:

    • Coal is not a product of delayed fungal evolution
      - Jan 19, 2016

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS March 1, 2016 113 (9) 2337-2340; https://doi.org/10.1073/pnas.ss1139

Physical Sciences

  • Applied Physical Sciences

    • Open Access
      Giant magneto-optical Raman effect in a layered transition metal compound
      Jianting Ji, Anmin Zhang, Jiahe Fan, Yuesheng Li, Xiaoqun Wang, Jiandi Zhang, E. W. Plummer, and Qingming Zhang
      PNAS March 1, 2016 113 (9) 2349-2353; first published February 16, 2016. https://doi.org/10.1073/pnas.1601010113
  • Chemistry

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      Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes
      Qi Xiao, Srujana S. Yadavalli, Shaodong Zhang, Samuel E. Sherman, Elodie Fiorin, Louise da Silva, Daniela A. Wilson, Daniel A. Hammer, Sabine André, Hans-Joachim Gabius, Michael L. Klein, Mark Goulian, and Virgil Percec
      PNAS March 1, 2016 113 (9) E1134-E1141; first published February 16, 2016. https://doi.org/10.1073/pnas.1525589113
    • Open Access
      Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells
      Salah Mansour, Anna S. Tocheva, Chris Cave-Ayland, Moritz M. Machelett, Barbara Sander, Nikolai M. Lissin, Peter E. Molloy, Mark S. Baird, Gunthard Stübs, Nicolas W. J. Schröder, Ralf R. Schumann, Jörg Rademann, Anthony D. Postle, Bent K. Jakobsen, Ben G. Marshall, Rajendra Gosain, Paul T. Elkington, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Ivo Tews, and Stephan D. Gadola
      PNAS March 1, 2016 113 (9) E1266-E1275; first published February 16, 2016. https://doi.org/10.1073/pnas.1519246113
  • Earth, Atmospheric, and Planetary Sciences

    • Open Access
      Widespread collapse of the Ross Ice Shelf during the late Holocene
      Yusuke Yokoyama, John B. Anderson, Masako Yamane, Lauren M. Simkins, Yosuke Miyairi, Takahiro Yamazaki, Mamito Koizumi, Hisami Suga, Kazuya Kusahara, Lindsay Prothro, Hiroyasu Hasumi, John R. Southon, and Naohiko Ohkouchi
      PNAS March 1, 2016 113 (9) 2354-2359; first published February 16, 2016. https://doi.org/10.1073/pnas.1516908113
    • Open Access
      Marine anoxia and delayed Earth system recovery after the end-Permian extinction
      Kimberly V. Lau, Kate Maher, Demir Altiner, Brian M. Kelley, Lee R. Kump, Daniel J. Lehrmann, Juan Carlos Silva-Tamayo, Karrie L. Weaver, Meiyi Yu, and Jonathan L. Payne
      PNAS March 1, 2016 113 (9) 2360-2365; first published February 16, 2016. https://doi.org/10.1073/pnas.1515080113
  • Engineering

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      Tailoring nanoparticle designs to target cancer based on tumor pathophysiology
      Edward A. Sykes, Qin Dai, Christopher D. Sarsons, Juan Chen, Jonathan V. Rocheleau, David M. Hwang, Gang Zheng, David T. Cramb, Kristina D. Rinker, and Warren C. W. Chan
      PNAS March 1, 2016 113 (9) E1142-E1151; first published February 16, 2016. https://doi.org/10.1073/pnas.1521265113
    • Open Access
      AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas
      Tracey L. Smith, Ziqiang Yuan, Marina Cardó-Vila, Carmen Sanchez Claros, Asha Adem, Min-Hui Cui, Craig A. Branch, Juri G. Gelovani, Steven K. Libutti, Richard L. Sidman, Renata Pasqualini, and Wadih Arap
      PNAS March 1, 2016 113 (9) 2466-2471; first published February 16, 2016. https://doi.org/10.1073/pnas.1525709113
  • Environmental Sciences

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      Delayed fungal evolution did not cause the Paleozoic peak in coal production
      • From the Cover
      Matthew P. Nelsen, William A. DiMichele, Shanan E. Peters, and C. Kevin Boyce
      PNAS March 1, 2016 113 (9) 2442-2447; first published January 19, 2016. https://doi.org/10.1073/pnas.1517943113

      See companion article:

      • A Late Paleozoic climate window of opportunity
        - Feb 16, 2016
  • Physics

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      Crossover from metal to insulator in dense lithium-rich compound CLi4
      Xilian Jin, Xiao-Jia Chen, Tian Cui, Ho-kwang Mao, Huadi Zhang, Quan Zhuang, Kuo Bao, Dawei Zhou, Bingbing Liu, Qiang Zhou, and Zhi He
      PNAS March 1, 2016 113 (9) 2366-2369; first published February 16, 2016. https://doi.org/10.1073/pnas.1525412113

Social Sciences

  • Psychological and Cognitive Sciences

    • Open Access
      Cortical response to categorical color perception in infants investigated by near-infrared spectroscopy
      Jiale Yang, So Kanazawa, Masami K. Yamaguchi, and Ichiro Kuriki
      PNAS March 1, 2016 113 (9) 2370-2375; first published February 8, 2016. https://doi.org/10.1073/pnas.1512044113
    • Open Access
      Infants use relative numerical group size to infer social dominance
      Anthea Pun, Susan A. J. Birch, and Andrew Scott Baron
      PNAS March 1, 2016 113 (9) 2376-2381; first published February 16, 2016. https://doi.org/10.1073/pnas.1514879113
  • Sustainability Science

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      Measuring the value of groundwater and other forms of natural capital
      Eli P. Fenichel, Joshua K. Abbott, Jude Bayham, Whitney Boone, Erin M. K. Haacker, and Lisa Pfeiffer
      PNAS March 1, 2016 113 (9) 2382-2387; first published February 8, 2016. https://doi.org/10.1073/pnas.1513779113

Biological Sciences

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      Genetically encoded sensors enable real-time observation of metabolite production
      Jameson K. Rogers and George M. Church
      PNAS March 1, 2016 113 (9) 2388-2393; first published February 8, 2016. https://doi.org/10.1073/pnas.1600375113
  • Biochemistry

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      Bioactive cell-like hybrids coassembled from (glyco)dendrimersomes with bacterial membranes
      Qi Xiao, Srujana S. Yadavalli, Shaodong Zhang, Samuel E. Sherman, Elodie Fiorin, Louise da Silva, Daniela A. Wilson, Daniel A. Hammer, Sabine André, Hans-Joachim Gabius, Michael L. Klein, Mark Goulian, and Virgil Percec
      PNAS March 1, 2016 113 (9) E1134-E1141; first published February 16, 2016. https://doi.org/10.1073/pnas.1525589113
    • You have access
      Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR
      Loes M. Stevers, Chan V. Lam, Seppe F. R. Leysen, Femke A. Meijer, Daphne S. van Scheppingen, Rens M. J. M. de Vries, Graeme W. Carlile, Lech G. Milroy, David Y. Thomas, Luc Brunsveld, and Christian Ottmann
      PNAS March 1, 2016 113 (9) E1152-E1161; first published February 17, 2016. https://doi.org/10.1073/pnas.1516631113
    • Open Access
      Calcium can mobilize and activate myosin-VI
      • From the Cover
      Christopher Batters, Dario Brack, Heike Ellrich, Beate Averbeck, and Claudia Veigel
      PNAS March 1, 2016 113 (9) E1162-E1169; first published January 25, 2016. https://doi.org/10.1073/pnas.1519435113

      See companion article:

      • Calcium gets myosin VI ready for work
        - Feb 19, 2016
    • Open Access
      Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins
      Logan R. Myler, Ignacio F. Gallardo, Yi Zhou, Fade Gong, Soo-Hyun Yang, Marc S. Wold, Kyle M. Miller, Tanya T. Paull, and Ilya J. Finkelstein
      PNAS March 1, 2016 113 (9) E1170-E1179; first published February 16, 2016. https://doi.org/10.1073/pnas.1516674113
    • Open Access
      70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria
      Hiroshi Yamamoto, Daniela Wittek, Romi Gupta, Bo Qin, Takuya Ueda, Roland Krause, Kaori Yamamoto, Renate Albrecht, Markus Pech, and Knud H. Nierhaus
      PNAS March 1, 2016 113 (9) E1180-E1189; first published February 17, 2016. https://doi.org/10.1073/pnas.1524554113
    • You have access
      Mechanism of a cytosolic O-glycosyltransferase essential for the synthesis of a bacterial adhesion protein
      Yu Chen, Ravin Seepersaud, Barbara A. Bensing, Paul M. Sullam, and Tom A. Rapoport
      PNAS March 1, 2016 113 (9) E1190-E1199; first published February 16, 2016. https://doi.org/10.1073/pnas.1600494113
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      First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer
      Emilia C. Arturo, Kushol Gupta, Annie Héroux, Linda Stith, Penelope J. Cross, Emily J. Parker, Patrick J. Loll, and Eileen K. Jaffe
      PNAS March 1, 2016 113 (9) 2394-2399; first published February 16, 2016. https://doi.org/10.1073/pnas.1516967113
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      A protein constructed de novo enables cell growth by altering gene regulation
      Katherine M. Digianantonio and Michael H. Hecht
      PNAS March 1, 2016 113 (9) 2400-2405; first published February 16, 2016. https://doi.org/10.1073/pnas.1600566113
  • Biophysics and Computational Biology

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      Novel actin filaments from Bacillus thuringiensis form nanotubules for plasmid DNA segregation
      Shimin Jiang, Akihiro Narita, David Popp, Umesh Ghoshdastider, Lin Jie Lee, Ramanujam Srinivasan, Mohan K. Balasubramanian, Toshiro Oda, Fujiet Koh, Mårten Larsson, and Robert C. Robinson
      PNAS March 1, 2016 113 (9) E1200-E1205; first published February 12, 2016. https://doi.org/10.1073/pnas.1600129113
    • You have access
      Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading
      Marija Iljina, Gonzalo A. Garcia, Mathew H. Horrocks, Laura Tosatto, Minee L. Choi, Kristina A. Ganzinger, Andrey Y. Abramov, Sonia Gandhi, Nicholas W. Wood, Nunilo Cremades, Christopher M. Dobson, Tuomas P. J. Knowles, and David Klenerman
      PNAS March 1, 2016 113 (9) E1206-E1215; first published February 16, 2016. https://doi.org/10.1073/pnas.1524128113
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      Conserved properties of individual Ca2+-binding sites in calmodulin
      D. Brent Halling, Benjamin J. Liebeskind, Amelia W. Hall, and Richard W. Aldrich
      PNAS March 1, 2016 113 (9) E1216-E1225; first published February 16, 2016. https://doi.org/10.1073/pnas.1600385113
    • You have access
      Enzyme catalysis by entropy without Circe effect
      • From the Cover
      Masoud Kazemi, Fahmi Himo, and Johan Åqvist
      PNAS March 1, 2016 113 (9) 2406-2411; first published January 11, 2016. https://doi.org/10.1073/pnas.1521020113

      See companion article:

      • Dispelling Circe's effect in enzyme catalysis
        - Feb 16, 2016
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      Load-dependent destabilization of the γ-rotor shaft in FOF1 ATP synthase revealed by hydrogen/deuterium-exchange mass spectrometry
      Siavash Vahidi, Yumin Bi, Stanley D. Dunn, and Lars Konermann
      PNAS March 1, 2016 113 (9) 2412-2417; first published February 16, 2016. https://doi.org/10.1073/pnas.1520464113
  • Cell Biology

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      MEKK2 mediates an alternative β-catenin pathway that promotes bone formation
      Matthew Blake Greenblatt, Dong Yeon Shin, Hwanhee Oh, Ki-Young Lee, Bo Zhai, Steven P. Gygi, Sutada Lotinun, Roland Baron, Dou Liu, Bing Su, Laurie H. Glimcher, and Jae-Hyuck Shim
      PNAS March 1, 2016 113 (9) E1226-E1235; first published February 16, 2016. https://doi.org/10.1073/pnas.1600813113
    • You have access
      The light chains of kinesin-1 are autoinhibited
      Yan Y. Yip, Stefano Pernigo, Anneri Sanger, Mengjia Xu, Maddy Parsons, Roberto A. Steiner, and Mark P. Dodding
      PNAS March 1, 2016 113 (9) 2418-2423; first published February 16, 2016. https://doi.org/10.1073/pnas.1520817113
    • Open Access
      Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells
      Hakan Cakmak, Federica Franciosi, A. Musa Zamah, Marcelle I. Cedars, and Marco Conti
      PNAS March 1, 2016 113 (9) 2424-2429; first published February 10, 2016. https://doi.org/10.1073/pnas.1519990113
  • Environmental Sciences

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      Oyster reproduction is affected by exposure to polystyrene microplastics
      • From the Cover
      Rossana Sussarellu, Marc Suquet, Yoann Thomas, Christophe Lambert, Caroline Fabioux, Marie Eve Julie Pernet, Nelly Le Goïc, Virgile Quillien, Christian Mingant, Yanouk Epelboin, Charlotte Corporeau, Julien Guyomarch, Johan Robbens, Ika Paul-Pont, Philippe Soudant, and Arnaud Huvet
      PNAS March 1, 2016 113 (9) 2430-2435; first published February 1, 2016. https://doi.org/10.1073/pnas.1519019113

      See companion article:

      • Marine microplastics affect future generations
        - Feb 22, 2016

      See companion article:

      • Realistic scenario for microplastic impact studies
        - Jul 12, 2016
    • Open Access
      Illuminating structural proteins in viral “dark matter” with metaproteomics
      Jennifer R. Brum, J. Cesar Ignacio-Espinoza, Eun-Hae Kim, Gareth Trubl, Robert M. Jones, Simon Roux, Nathan C. VerBerkmoes, Virginia I. Rich, and Matthew B. Sullivan
      PNAS March 1, 2016 113 (9) 2436-2441; first published February 16, 2016. https://doi.org/10.1073/pnas.1525139113
  • Evolution

    • You have access
      Delayed fungal evolution did not cause the Paleozoic peak in coal production
      • From the Cover
      Matthew P. Nelsen, William A. DiMichele, Shanan E. Peters, and C. Kevin Boyce
      PNAS March 1, 2016 113 (9) 2442-2447; first published January 19, 2016. https://doi.org/10.1073/pnas.1517943113

      See companion article:

      • A Late Paleozoic climate window of opportunity
        - Feb 16, 2016
    • You have access
      Competition between anthocyanin and flavonol biosynthesis produces spatial pattern variation of floral pigments between Mimulus species
      Yao-Wu Yuan, Alexandra B. Rebocho, Janelle M. Sagawa, Lauren E. Stanley, and Harvey D. Bradshaw Jr.
      PNAS March 1, 2016 113 (9) 2448-2453; first published February 16, 2016. https://doi.org/10.1073/pnas.1515294113
  • Genetics

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      Deep phenotyping of 89 xeroderma pigmentosum patients reveals unexpected heterogeneity dependent on the precise molecular defect
      Hiva Fassihi, Mieran Sethi, Heather Fawcett, Jonathan Wing, Natalie Chandler, Shehla Mohammed, Emma Craythorne, Ana M. S. Morley, Rongxuan Lim, Sally Turner, Tanya Henshaw, Isabel Garrood, Paola Giunti, Tammy Hedderly, Adesoji Abiona, Harsha Naik, Gemma Harrop, David McGibbon, Nicolaas G. J. Jaspers, Elena Botta, Tiziana Nardo, Miria Stefanini, Antony R. Young, Robert P. E. Sarkany, and Alan R. Lehmann
      PNAS March 1, 2016 113 (9) E1236-E1245; first published February 16, 2016. https://doi.org/10.1073/pnas.1519444113
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      Phagocytosis genes nonautonomously promote developmental cell death in the Drosophila ovary
      Allison K. Timmons, Albert A. Mondragon, Claire E. Schenkel, Alla Yalonetskaya, Jeffrey D. Taylor, Katherine E. Moynihan, Jon Iker Etchegaray, Tracy L. Meehan, and Kimberly McCall
      PNAS March 1, 2016 113 (9) E1246-E1255; first published February 16, 2016. https://doi.org/10.1073/pnas.1522830113
    • Open Access
      Sex-specific regulation of Lgr3 in Drosophila neurons
      Geoffrey W. Meissner, Shengzhan D. Luo, Brian G. Dias, Michael J. Texada, and Bruce S. Baker
      PNAS March 1, 2016 113 (9) E1256-E1265; first published February 16, 2016. https://doi.org/10.1073/pnas.1600241113
    • Open Access
      Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes
      Geoffrey J. Maher, Simon J. McGowan, Eleni Giannoulatou, Clare Verrill, Anne Goriely, and Andrew O. M. Wilkie
      PNAS March 1, 2016 113 (9) 2454-2459; first published February 8, 2016. https://doi.org/10.1073/pnas.1521325113
  • Immunology and Inflammation

    • Open Access
      Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells
      Salah Mansour, Anna S. Tocheva, Chris Cave-Ayland, Moritz M. Machelett, Barbara Sander, Nikolai M. Lissin, Peter E. Molloy, Mark S. Baird, Gunthard Stübs, Nicolas W. J. Schröder, Ralf R. Schumann, Jörg Rademann, Anthony D. Postle, Bent K. Jakobsen, Ben G. Marshall, Rajendra Gosain, Paul T. Elkington, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Ivo Tews, and Stephan D. Gadola
      PNAS March 1, 2016 113 (9) E1266-E1275; first published February 16, 2016. https://doi.org/10.1073/pnas.1519246113
    • You have access
      How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
      Sydney J. Blevins, Brian G. Pierce, Nishant K. Singh, Timothy P. Riley, Yuan Wang, Timothy T. Spear, Michael I. Nishimura, Zhiping Weng, and Brian M. Baker
      PNAS March 1, 2016 113 (9) E1276-E1285; first published February 16, 2016. https://doi.org/10.1073/pnas.1522069113
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      Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets
      John F. Ryan, Rachel Hovde, Jacob Glanville, Shu-Chen Lyu, Xuhuai Ji, Sheena Gupta, Robert J. Tibshirani, David C. Jay, Scott D. Boyd, R. Sharon Chinthrajah, Mark M. Davis, Stephen J. Galli, Holden T. Maecker, and Kari C. Nadeau
      PNAS March 1, 2016 113 (9) E1286-E1295; first published January 25, 2016. https://doi.org/10.1073/pnas.1520180113
    • Open Access
      CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity
      Kazuyuki Akane, Seiji Kojima, Tak W. Mak, Hiroshi Shiku, and Haruhiko Suzuki
      PNAS March 1, 2016 113 (9) 2460-2465; first published February 11, 2016. https://doi.org/10.1073/pnas.1525098113
  • Medical Sciences

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      Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
      Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, and Lynda Chin
      PNAS March 1, 2016 113 (9) E1296-E1305; first published February 16, 2016. https://doi.org/10.1073/pnas.1513801113
    • Open Access
      AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas
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      PNAS March 1, 2016 113 (9) 2466-2471; first published February 16, 2016. https://doi.org/10.1073/pnas.1525709113
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      Gene control of tyrosine kinase TIE2 and vascular manifestations of infections
      Chandra C. Ghosh, Sascha David, Ruyang Zhang, Anthony Berghelli, Katelyn Milam, Sarah J. Higgins, Jon Hunter, Aditi Mukherjee, Yongyue Wei, Mei Tran, Freeman Suber, Lester Kobzik, Kevin C. Kain, Shulin Lu, Ansgar Santel, Kiichiro Yano, Prajna Guha, Daniel J. Dumont, David C. Christiani, and Samir M. Parikh
      PNAS March 1, 2016 113 (9) 2472-2477; first published February 16, 2016. https://doi.org/10.1073/pnas.1519467113
  • Microbiology

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      Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice
      Jun Li, Cecilia Ying Ju Sung, Nikki Lee, Yueqiong Ni, Jussi Pihlajamäki, Gianni Panagiotou, and Hani El-Nezami
      PNAS March 1, 2016 113 (9) E1306-E1315; first published February 16, 2016. https://doi.org/10.1073/pnas.1518189113
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      Differential regulation of type III secretion and virulence genes in Bordetella pertussis and Bordetella bronchiseptica by a secreted anti-σ factor
      • Inaugural Article
      Umesh Ahuja, Bhumika Shokeen, Ning Cheng, Yeonjoo Cho, Charles Blum, Giovanni Coppola, and Jeff F. Miller
      PNAS March 1, 2016 113 (9) 2341-2348; first published February 16, 2016. https://doi.org/10.1073/pnas.1600320113
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      A virus of hyperthermophilic archaea with a unique architecture among DNA viruses
      Elena Ilka Rensen, Tomohiro Mochizuki, Emmanuelle Quemin, Stefan Schouten, Mart Krupovic, and David Prangishvili
      PNAS March 1, 2016 113 (9) 2478-2483; first published February 16, 2016. https://doi.org/10.1073/pnas.1518929113
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      Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
      Marion Lussignol, Martina Kopp, Kelly Molloy, Gema Vizcay-Barrena, Roland A. Fleck, Marcus Dorner, Kierstin L. Bell, Brian T. Chait, Charles M. Rice, and Maria Teresa Catanese
      PNAS March 1, 2016 113 (9) 2484-2489; first published February 16, 2016. https://doi.org/10.1073/pnas.1518934113
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      CnaA domains in bacterial pili are efficient dissipaters of large mechanical shocks
      Daniel J. Echelman, Jorge Alegre-Cebollada, Carmen L. Badilla, Chungyu Chang, Hung Ton-That, and Julio M. Fernández
      PNAS March 1, 2016 113 (9) 2490-2495; first published February 16, 2016. https://doi.org/10.1073/pnas.1522946113
    • Open Access
      The archaeal Ced system imports DNA
      Marleen van Wolferen, Alexander Wagner, Chris van der Does, and Sonja-Verena Albers
      PNAS March 1, 2016 113 (9) 2496-2501; first published February 16, 2016. https://doi.org/10.1073/pnas.1513740113
    • Open Access
      A highly precise and portable genome engineering method allows comparison of mutational effects across bacterial species
      Ákos Nyerges, Bálint Csörgő, István Nagy, Balázs Bálint, Péter Bihari, Viktória Lázár, Gábor Apjok, Kinga Umenhoffer, Balázs Bogos, György Pósfai, and Csaba Pál
      PNAS March 1, 2016 113 (9) 2502-2507; first published February 16, 2016. https://doi.org/10.1073/pnas.1520040113
  • Neuroscience

    • Open Access
      The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function
      Samuel E. Marsh, Edsel M. Abud, Anita Lakatos, Alborz Karimzadeh, Stephen T. Yeung, Hayk Davtyan, Gianna M. Fote, Lydia Lau, Jason G. Weinger, Thomas E. Lane, Matthew A. Inlay, Wayne W. Poon, and Mathew Blurton-Jones
      PNAS March 1, 2016 113 (9) E1316-E1325; first published February 16, 2016. https://doi.org/10.1073/pnas.1525466113
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      Midbrain auditory selectivity to natural sounds
      Melville J. Wohlgemuth and Cynthia F. Moss
      PNAS March 1, 2016 113 (9) 2508-2513; first published February 16, 2016. https://doi.org/10.1073/pnas.1517451113
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      Targeted axonal import (TAxI) peptide delivers functional proteins into spinal cord motor neurons after peripheral administration
      • From the Cover
      Drew L. Sellers, Jamie M. Bergen, Russell N. Johnson, Heidi Back, John M. Ravits, Philip J. Horner, and Suzie H. Pun
      PNAS March 1, 2016 113 (9) 2514-2519; first published February 17, 2016. https://doi.org/10.1073/pnas.1515526113
    • Open Access
      Consumption of palatable food primes food approach behavior by rapidly increasing synaptic density in the VTA
      Shuai Liu, Andrea K. Globa, Fergil Mills, Lindsay Naef, Min Qiao, Shernaz X. Bamji, and Stephanie L. Borgland
      PNAS March 1, 2016 113 (9) 2520-2525; first published February 16, 2016. https://doi.org/10.1073/pnas.1515724113
  • Plant Biology

    • You have access
      Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis
      Sibongile Mafu, Meirong Jia, Jiachen Zi, Dana Morrone, Yisheng Wu, Meimei Xu, Matthew L. Hillwig, and Reuben J. Peters
      PNAS March 1, 2016 113 (9) 2526-2531; first published February 16, 2016. https://doi.org/10.1073/pnas.1512096113
  • Psychological and Cognitive Sciences

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      Brain size predicts problem-solving ability in mammalian carnivores
      Sarah Benson-Amram, Ben Dantzer, Gregory Stricker, Eli M. Swanson, and Kay E. Holekamp
      PNAS March 1, 2016 113 (9) 2532-2537; first published January 25, 2016. https://doi.org/10.1073/pnas.1505913113
    • Open Access
      Slow dissolving of emotional distress contributes to hyperarousal
      Rick Wassing, Jeroen S. Benjamins, Kim Dekker, Sarah Moens, Kai Spiegelhalder, Bernd Feige, Dieter Riemann, Sophie van der Sluis, Ysbrand D. Van Der Werf, Lucia M. Talamini, Matthew P. Walker, Frans Schalkwijk, and Eus J. W. Van Someren
      PNAS March 1, 2016 113 (9) 2538-2543; first published February 8, 2016. https://doi.org/10.1073/pnas.1522520113
  • Systems Biology

    • Open Access
      Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM
      Alan S. L. Wong, Gigi C. G. Choi, Cheryl H. Cui, Gabriela Pregernig, Pamela Milani, Miriam Adam, Samuel D. Perli, Samuel W. Kazer, Aleth Gaillard, Mario Hermann, Alex K. Shalek, Ernest Fraenkel, and Timothy K. Lu
      PNAS March 1, 2016 113 (9) 2544-2549; first published February 10, 2016. https://doi.org/10.1073/pnas.1517883113

Corrections (Online Only)

  • You have access
    Correction for Strickland et al., Event representations constrain the structure of language: Sign language as a window into universally accessible linguistic biases
    PNAS March 1, 2016 113 (9) E1326; first published February 16, 2016. https://doi.org/10.1073/pnas.1600619113
  • You have access
    Correction for Upadhyay et al., Intracranial microcapsule chemotherapy delivery for the localized treatment of rodent metastatic breast adenocarcinoma in the brain
    PNAS March 1, 2016 113 (9) E1327; first published February 16, 2016. https://doi.org/10.1073/pnas.1600771113
  • You have access
    Correction for Kumar et al., Natural history-driven, plant-mediated RNAi-based study reveals CYP6B46’s role in a nicotine-mediated antipredator herbivore defense
    PNAS March 1, 2016 113 (9) E1328; first published February 16, 2016. https://doi.org/10.1073/pnas.1600609113
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Proceedings of the National Academy of Sciences: 113 (9)
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