AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in neuroendocrine tumors of the pancreas

New Research In

Contributed by Richard L. Sidman, January 4, 2016 (sent for review December 7, 2015; reviewed by Herbert Chen, James Howe, and Raphael E. Pollock)

vol. 113 no. 9 2466-2471

DOI:

PubMed:

Published By:

Print ISSN:

Online ISSN:

History:

Freely available online through the PNAS open access option.

^aUniversity of New Mexico Comprehensive Cancer Center, Albuquerque, NM 87131;
^bDivision of Molecular Medicine, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131;
^cDepartment of Surgery, Albert Einstein College of Medicine, Bronx, NY 10461;
^dDepartment of Radiology, Albert Einstein College of Medicine, Bronx, NY 10461;
^eDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461;
^fDepartment of Biomedical Engineering, Wayne State University, Detroit, MI 48201;
^gDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461;
^hDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215;
ⁱDivision of Hematology/Oncology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131

Contributed by Richard L. Sidman, January 4, 2016 (sent for review December 7, 2015; reviewed by Herbert Chen, James Howe, and Raphael E. Pollock)

↵¹To whom correspondence may be addressed. Email: richard_sidman{at}hms.harvard.edu, rpasqual{at}salud.unm.edu, or warap{at}salud.unm.edu.
↵²R.P. and W.A. contributed equally to this work.

Author contributions: T.L.S., M.C.-V., C.A.B., S.K.L., R.L.S., R.P., and W.A. designed research; T.L.S., Z.Y., M.C.-V., C.S.C., A.A., and M.-H.C. performed research; T.L.S., Z.Y., A.A., M.-H.C., and J.G.G. contributed new reagents/analytic tools; T.L.S., Z.Y., M.C.-V., C.S.C., A.A., M.-H.C., J.G.G., S.K.L., R.L.S., R.P., and W.A. analyzed data; and T.L.S., M.C.-V., S.K.L., R.L.S., R.P., and W.A. wrote the paper.
Reviewers: H.C., University of Alabama; J.H., University of Iowa Carver College of Medicine; and R.E.P., Ohio State University Wexner Medical Center.
Conflict of interest statement: J.G.G., S.K.L., R.P., and W.A. are founders of and equity holders in AAVP BioSystems. R.P. and W.A. are inventors listed on patent applications related to this work and will be entitled to standard royalties if licensing and/or commercialization occurs. The University of New Mexico Health Sciences Center currently manages these arrangements in accordance with its established institutional conflict of interest policy.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1525709113/-/DCSupplemental.