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Biological Sciences

• Agricultural Sciences

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    In vivo diagnostics of early abiotic plant stress response via Raman spectroscopy

    Narangerel Altangerel, Gombojav O. Ariunbold, Connor Gorman, Masfer H. Alkahtani, Eli J. Borrego, Dwight Bohlmeyer, Philip Hemmer, Michael V. Kolomiets, Joshua S. Yuan, and Marlan O. Scully

    PNAS March 28, 2017 114 (13) 3393-3396; first published March 13, 2017. https://doi.org/10.1073/pnas.1701328114

    See companion article:

    • Plant stress via Raman spectroscopy

      - Jun 27, 2017

• Anthropology

  • Open Access

    Cross-cousin marriage among the Yanomamö shows evidence of parent–offspring conflict and mate competition between brothers

    Napoleon A. Chagnon, Robert F. Lynch, Mary K. Shenk, Raymond Hames, and Mark V. Flinn

    PNAS March 28, 2017 114 (13) E2590-E2607; first published March 13, 2017. https://doi.org/10.1073/pnas.1618655114
  • Open Access

    New Middle Pleistocene hominin cranium from Gruta da Aroeira (Portugal)

    • From the Cover

    Joan Daura, Montserrat Sanz, Juan Luis Arsuaga, Dirk L. Hoffmann, Rolf M. Quam, María Cruz Ortega, Elena Santos, Sandra Gómez, Angel Rubio, Lucía Villaescusa, Pedro Souto, João Mauricio, Filipa Rodrigues, Artur Ferreira, Paulo Godinho, Erik Trinkaus, and João Zilhão

    PNAS March 28, 2017 114 (13) 3397-3402; first published March 13, 2017. https://doi.org/10.1073/pnas.1619040114

• Applied Biological Sciences

  • Open Access

    Morphological features of IFN-γ–stimulated mesenchymal stromal cells predict overall immunosuppressive capacity

    Matthew W. Klinker, Ross A. Marklein, Jessica L. Lo Surdo, Cheng-Hong Wei, and Steven R. Bauer

    PNAS March 28, 2017 114 (13) E2598-E2607; first published March 10, 2017. https://doi.org/10.1073/pnas.1617933114

• Biochemistry

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    Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism

    Sahil Gulati, Beata Jastrzebska, Surajit Banerjee, Ángel L. Placeres, Przemyslaw Miszta, Songqi Gao, Karl Gunderson, Gregory P. Tochtrop, Sławomir Filipek, Kota Katayama, Philip D. Kiser, Muneto Mogi, Phoebe L. Stewart, and Krzysztof Palczewski

    PNAS March 28, 2017 114 (13) E2608-E2615; first published March 13, 2017. https://doi.org/10.1073/pnas.1617446114
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    Phytosphingosine degradation pathway includes fatty acid α-oxidation reactions in the endoplasmic reticulum

    Takuya Kitamura, Naoya Seki, and Akio Kihara

    PNAS March 28, 2017 114 (13) E2616-E2623; first published March 13, 2017. https://doi.org/10.1073/pnas.1700138114
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    Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins

    Claire N. Bedbrook, Austin J. Rice, Kevin K. Yang, Xiaozhe Ding, Siyuan Chen, Emily M. LeProust, Viviana Gradinaru, and Frances H. Arnold

    PNAS March 28, 2017 114 (13) E2624-E2633; first published March 10, 2017. https://doi.org/10.1073/pnas.1700269114
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    Multisite aggregation of p53 and implications for drug rescue

    GuoZhen Wang and Alan R. Fersht

    PNAS March 28, 2017 114 (13) E2634-E2643; first published March 14, 2017. https://doi.org/10.1073/pnas.1700308114
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    Distinct recognition of complement iC3b by integrins α_Xβ₂ and α_Mβ₂

    Shutong Xu, Jianchuan Wang, Jia-Huai Wang, and Timothy A. Springer

    PNAS March 28, 2017 114 (13) 3403-3408; first published March 14, 2017. https://doi.org/10.1073/pnas.1620881114
  • Open Access

    Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

    Jiuya He, Holly C. Ford, Joe Carroll, Shujing Ding, Ian M. Fearnley, and John E. Walker

    PNAS March 28, 2017 114 (13) 3409-3414; first published March 13, 2017. https://doi.org/10.1073/pnas.1702357114

• Biophysics and Computational Biology

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    Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

    Prakash Kulkarni, Mohit Kumar Jolly, Dongya Jia, Steven M. Mooney, Ajay Bhargava, Luciane T. Kagohara, Yihong Chen, Pengyu Hao, Yanan He, Robert W. Veltri, Alexander Grishaev, Keith Weninger, Herbert Levine, and John Orban

    PNAS March 28, 2017 114 (13) E2644-E2653; first published March 13, 2017. https://doi.org/10.1073/pnas.1700082114
  • Open Access

    Bacterial proteostasis balances energy and chaperone utilization efficiently

    Mantu Santra, Daniel W. Farrell, and Ken A. Dill

    PNAS March 28, 2017 114 (13) E2654-E2661; first published March 14, 2017. https://doi.org/10.1073/pnas.1620646114
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    Large-scale identification of coevolution signals across homo-oligomeric protein interfaces by direct coupling analysis

    Guido Uguzzoni, Shalini John Lovis, Francesco Oteri, Alexander Schug, Hendrik Szurmant, and Martin Weigt

    PNAS March 28, 2017 114 (13) E2662-E2671; first published March 13, 2017. https://doi.org/10.1073/pnas.1615068114
  • Open Access

    Topological knots and links in proteins

    Pawel Dabrowski-Tumanski and Joanna I. Sulkowska

    PNAS March 28, 2017 114 (13) 3415-3420; first published March 9, 2017. https://doi.org/10.1073/pnas.1615862114
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    Ligand-induced allostery in the interaction of the Pseudomonas aeruginosa heme binding protein with heme oxygenase

    Daniel J. Deredge, Weiliang Huang, Colleen Hui, Hirotoshi Matsumura, Zhi Yue, Pierre Moënne-Loccoz, Jana Shen, Patrick L. Wintrode, and Angela Wilks

    PNAS March 28, 2017 114 (13) 3421-3426; first published March 13, 2017. https://doi.org/10.1073/pnas.1606931114
  • Open Access

    Steady-state EB cap size fluctuations are determined by stochastic microtubule growth and maturation

    Jamie Rickman, Christian Duellberg, Nicholas I. Cade, Lewis D. Griffin, and Thomas Surrey

    PNAS March 28, 2017 114 (13) 3427-3432; first published March 9, 2017. https://doi.org/10.1073/pnas.1620274114

• Cell Biology

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    Fission yeast myosin I facilitates PI(4,5)P₂-mediated anchoring of cytoplasmic dynein to the cortex

    Jerrin Mathew Thankachan, Stephen Sukumar Nuthalapati, Nireekshit Addanki Tirumala, and Vaishnavi Ananthanarayanan

    PNAS March 28, 2017 114 (13) E2672-E2681; first published March 14, 2017. https://doi.org/10.1073/pnas.1615883114
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    Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network

    Lydia Daboussi, Giancarlo Costaguta, Razmik Ghukasyan, and Gregory S. Payne

    PNAS March 28, 2017 114 (13) 3433-3438; first published March 13, 2017. https://doi.org/10.1073/pnas.1615163114
  • Open Access

    Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress

    Victoria L. Hale, Jean M. Watermeyer, Fiona Hackett, Gema Vizcay-Barrena, Christiaan van Ooij, James A. Thomas, Matthew C. Spink, Maria Harkiolaki, Elizabeth Duke, Roland A. Fleck, Michael J. Blackman, and Helen R. Saibil

    PNAS March 28, 2017 114 (13) 3439-3444; first published March 14, 2017. https://doi.org/10.1073/pnas.1619441114

• Developmental Biology

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    Toll pathway is required for wound-induced expression of barrier repair genes in the Drosophila epidermis

    Amalia Capilla, Dmitry Karachentsev, Rachel A. Patterson, Anita Hermann, Michelle T. Juarez, and William McGinnis

    PNAS March 28, 2017 114 (13) E2682-E2688; first published March 13, 2017. https://doi.org/10.1073/pnas.1613917114
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    AMPK blocks starvation-inducible transgenerational defects in Caenorhabditis elegans

    Emilie Demoinet, Shaolin Li, and Richard Roy

    PNAS March 28, 2017 114 (13) E2689-E2698; first published March 13, 2017. https://doi.org/10.1073/pnas.1616171114
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    Injury-stimulated and self-restrained BMP signaling dynamically regulates stem cell pool size during Drosophila midgut regeneration

    Aiguo Tian, Bing Wang, and Jin Jiang

    PNAS March 28, 2017 114 (13) E2699-E2708; first published March 13, 2017. https://doi.org/10.1073/pnas.1617790114
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    Hormone and receptor interplay in the regulation of mosquito lipid metabolism

    Xueli Wang, Yuan Hou, Tusar T. Saha, Gaofeng Pei, Alexander S. Raikhel, and Zhen Zou

    PNAS March 28, 2017 114 (13) E2709-E2718; first published March 14, 2017. https://doi.org/10.1073/pnas.1619326114
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    Specific deletion of LKB1/Stk11 in the Müllerian duct mesenchyme drives hyperplasia of the periurethral stroma and tumorigenesis in male mice

    Jitu W. George, Amanda L. Patterson, Pradeep S. Tanwar, André Kajdacsy-Balla, Gail S. Prins, and Jose M. Teixeira

    PNAS March 28, 2017 114 (13) 3445-3450; first published March 13, 2017. https://doi.org/10.1073/pnas.1612284114

• Ecology

  • Open Access

    Multitrait successional forest dynamics enable diverse competitive coexistence

    Daniel S. Falster, Åke Brännström, Mark Westoby, and Ulf Dieckmann

    PNAS March 28, 2017 114 (13) E2719-E2728; first published March 10, 2017. https://doi.org/10.1073/pnas.1610206114
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    Volatile secondary metabolites as aposematic olfactory signals and defensive weapons in aquatic environments

    Giuseppe Giordano, Marianna Carbone, Maria Letizia Ciavatta, Eleonora Silvano, Margherita Gavagnin, Mary J. Garson, Karen L. Cheney, I Wayan Mudianta, Giovanni Fulvio Russo, Guido Villani, Laura Magliozzi, Gianluca Polese, Christian Zidorn, Adele Cutignano, Angelo Fontana, Michael T. Ghiselin, and Ernesto Mollo

    PNAS March 28, 2017 114 (13) 3451-3456; first published March 13, 2017. https://doi.org/10.1073/pnas.1614655114
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    Fossil and genomic evidence constrains the timing of bison arrival in North America

    • From the Cover

    Duane Froese, Mathias Stiller, Peter D. Heintzman, Alberto V. Reyes, Grant D. Zazula, André E. R. Soares, Matthias Meyer, Elizabeth Hall, Britta J. L. Jensen, Lee J. Arnold, Ross D. E. MacPhee, and Beth Shapiro

    PNAS March 28, 2017 114 (13) 3457-3462; first published March 13, 2017. https://doi.org/10.1073/pnas.1620754114
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    Flowering phenology shifts in response to biodiversity loss

    Amelia A. Wolf, Erika S. Zavaleta, and Paul C. Selmants

    PNAS March 28, 2017 114 (13) 3463-3468; first published March 13, 2017. https://doi.org/10.1073/pnas.1608357114

• Evolution

  • Open Access

    Osmolality/salinity-responsive enhancers (OSREs) control induction of osmoprotective genes in euryhaline fish

    Xiaodan Wang and Dietmar Kültz

    PNAS March 28, 2017 114 (13) E2729-E2738; first published March 13, 2017. https://doi.org/10.1073/pnas.1614712114
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    Storage and release of hydrogen cyanide in a chelicerate (Oribatula tibialis)

    Adrian Brückner, Günther Raspotnig, Katja Wehner, Reinhard Meusinger, Roy A. Norton, and Michael Heethoff

    PNAS March 28, 2017 114 (13) 3469-3472; first published March 13, 2017. https://doi.org/10.1073/pnas.1618327114

• Genetics

  • Open Access

    Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice

    Danny Halim, Michael P. Wilson, Daniel Oliver, Erwin Brosens, Joke B. G. M. Verheij, Yu Han, Vivek Nanda, Qing Lyu, Michael Doukas, Hans Stoop, Rutger W. W. Brouwer, Wilfred F. J. van IJcken, Orazio J. Slivano, Alan J. Burns, Christine K. Christie, Karen L. de Mesy Bentley, Alice S. Brooks, Dick Tibboel, Suowen Xu, Zheng Gen Jin, Tono Djuwantono, Wei Yan, Maria M. Alves, Robert M. W. Hofstra, and Joseph M. Miano

    PNAS March 28, 2017 114 (13) E2739-E2747; first published March 14, 2017. https://doi.org/10.1073/pnas.1620507114
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    Transcriptional landscape of the human cell cycle

    Yin Liu, Sujun Chen, Su Wang, Fraser Soares, Martin Fischer, Feilong Meng, Zhou Du, Charles Lin, Clifford Meyer, James A. DeCaprio, Myles Brown, X. Shirley Liu, and Housheng Hansen He

    PNAS March 28, 2017 114 (13) 3473-3478; first published March 13, 2017. https://doi.org/10.1073/pnas.1617636114
  • Open Access

    Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity

    Alireza Baradaran-Heravi, Jürgen Niesser, Aruna D. Balgi, Kunho Choi, Carla Zimmerman, Andrew P. South, Hilary J. Anderson, Natalie C. Strynadka, Marcel B. Bally, and Michel Roberge

    PNAS March 28, 2017 114 (13) 3479-3484; first published March 13, 2017. https://doi.org/10.1073/pnas.1620982114

• Immunology and Inflammation

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    Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36γ

    Joseph S. Ainscough, Tom Macleod, Dennis McGonagle, Rosella Brakefield, Jens M. Baron, Ade Alase, Miriam Wittmann, and Martin Stacey

    PNAS March 28, 2017 114 (13) E2748-E2757; first published March 13, 2017. https://doi.org/10.1073/pnas.1620954114
  • Open Access

    Receptor Mincle promotes skin allergies and is capable of recognizing cholesterol sulfate

    Alexey V. Kostarnoy, Petya G. Gancheva, Bernd Lepenies, Amir I. Tukhvatulin, Alina S. Dzharullaeva, Nikita B. Polyakov, Daniil A. Grumov, Daria A. Egorova, Andrey Y. Kulibin, Maxim A. Bobrov, Ekaterina A. Malolina, Pavel A. Zykin, Andrey I. Soloviev, Evgeniy Riabenko, Diana V. Maltseva, Dmitry A. Sakharov, Alexander G. Tonevitsky, Lyudmila V. Verkhovskaya, Denis Y. Logunov, Boris S. Naroditsky, and Alexander L. Gintsburg

    PNAS March 28, 2017 114 (13) E2758-E2765; first published March 14, 2017. https://doi.org/10.1073/pnas.1611665114
  • Open Access

    Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo

    Yaw Asare, Miriam Ommer, Florence. A. Azombo, Setareh Alampour-Rajabi, Marieke Sternkopf, Maryam Sanati, Marion J. Gijbels, Corinna Schmitz, Dzmitry Sinitski, Pathricia V. Tilstam, Hongqi Lue, André Gessner, Denise Lange, Johannes A. Schmid, Christian Weber, Martin Dichgans, Joachim Jankowski, Ruggero Pardi, Menno P. J. de Winther, Heidi Noels, and Jürgen Bernhagen

    PNAS March 28, 2017 114 (13) E2766-E2775; first published March 14, 2017. https://doi.org/10.1073/pnas.1618411114
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    Exhaustion-associated regulatory regions in CD8⁺ tumor-infiltrating T cells

    Giuliana P. Mognol, Roberto Spreafico, Victor Wong, James P. Scott-Browne, Susan Togher, Alexander Hoffmann, Patrick G. Hogan, Anjana Rao, and Sara Trifari

    PNAS March 28, 2017 114 (13) E2776-E2785; first published March 10, 2017. https://doi.org/10.1073/pnas.1620498114
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    Modulating IgG effector function by Fc glycan engineering

    Tiezheng Li, David J. DiLillo, Stylianos Bournazos, John P. Giddens, Jeffrey V. Ravetch, and Lai-Xi Wang

    PNAS March 28, 2017 114 (13) 3485-3490; first published March 13, 2017. https://doi.org/10.1073/pnas.1702173114
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    Genetic variation in chromosome Y regulates susceptibility to influenza A virus infection

    • From the Cover

    Dimitry N. Krementsov, Laure K. Case, Oliver Dienz, Abbas Raza, Qian Fang, Jennifer L. Ather, Matthew E. Poynter, Jonathan E. Boyson, Janice Y. Bunn, and Cory Teuscher

    PNAS March 28, 2017 114 (13) 3491-3496; first published February 27, 2017. https://doi.org/10.1073/pnas.1620889114

    See companion article:

    • Y chromosome and sex differences in disease

      - Mar 30, 2017

• Medical Sciences

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    Small molecule selectively suppresses MYC transcription in cancer cells

    Claire Bouvard, Sang Min Lim, John Ludka, Nahid Yazdani, Ashley K. Woods, Arnab K. Chatterjee, Peter G. Schultz, and Shoutian Zhu

    PNAS March 28, 2017 114 (13) 3497-3502; first published March 14, 2017. https://doi.org/10.1073/pnas.1702663114
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    B vitamins attenuate the epigenetic effects of ambient fine particles in a pilot human intervention trial

    Jia Zhong, Oskar Karlsson, Guan Wang, Jun Li, Yichen Guo, Xinyi Lin, Michele Zemplenyi, Marco Sanchez-Guerra, Letizia Trevisi, Bruce Urch, Mary Speck, Liming Liang, Brent A. Coull, Petros Koutrakis, Frances Silverman, Diane R. Gold, Tangchun Wu, and Andrea A. Baccarelli

    PNAS March 28, 2017 114 (13) 3503-3508; first published March 13, 2017. https://doi.org/10.1073/pnas.1618545114

    See companion article:

    • Interpretation of a small mechanistic study

      - May 08, 2017
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    Selective dietary supplementation in early postpartum is associated with high resilience against depressed mood

    Yekta Dowlati, Arun V. Ravindran, Zindel V. Segal, Donna E. Stewart, Meir Steiner, and Jeffrey H. Meyer

    PNAS March 28, 2017 114 (13) 3509-3514; first published March 13, 2017. https://doi.org/10.1073/pnas.1611965114

• Microbiology

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    Mouse cytomegalovirus M36 and M45 death suppressors cooperate to prevent inflammation resulting from antiviral programmed cell death pathways

    Lisa P. Daley-Bauer, Linda Roback, Lynsey N. Crosby, A. Louise McCormick, Yanjun Feng, William J. Kaiser, and Edward S. Mocarski

    PNAS March 28, 2017 114 (13) E2786-E2795; first published March 14, 2017. https://doi.org/10.1073/pnas.1616829114
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    Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort

    Ricardo Ataide, Elizabeth A. Ashley, Rosanna Powell, Jo-Anne Chan, Michael J. Malloy, Katherine O’Flaherty, Eizo Takashima, Christine Langer, Takafumi Tsuboi, Arjen M. Dondorp, Nicholas P. Day, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M. Abul Faiz, James G. Beeson, Francois Nosten, Julie A. Simpson, Nicholas J. White, and Freya J. I. Fowkes

    PNAS March 28, 2017 114 (13) 3515-3520; first published March 13, 2017. https://doi.org/10.1073/pnas.1615875114

• Neuroscience

  • Open Access

    Overcoming catastrophic forgetting in neural networks

    James Kirkpatrick, Razvan Pascanu, Neil Rabinowitz, Joel Veness, Guillaume Desjardins, Andrei A. Rusu, Kieran Milan, John Quan, Tiago Ramalho, Agnieszka Grabska-Barwinska, Demis Hassabis, Claudia Clopath, Dharshan Kumaran, and Raia Hadsell

    PNAS March 28, 2017 114 (13) 3521-3526; first published March 14, 2017. https://doi.org/10.1073/pnas.1611835114

    See companion article:

    • Reply to Huszár: The elastic weight consolidation penalty is empirically valid

      - Feb 20, 2018
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    Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion

    Aristeidis Sotiras, Jon B. Toledo, Raquel E. Gur, Ruben C. Gur, Theodore D. Satterthwaite, and Christos Davatzikos

    PNAS March 28, 2017 114 (13) 3527-3532; first published March 13, 2017. https://doi.org/10.1073/pnas.1620928114

• Plant Biology

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    BRASSINOSTEROID INSENSITIVE2 negatively regulates cellulose synthesis in Arabidopsis by phosphorylating cellulose synthase 1

    Clara Sánchez-Rodríguez, KassaDee Ketelaar, Rene Schneider, Jose A. Villalobos, Chris R. Somerville, Staffan Persson, and Ian S. Wallace

    PNAS March 28, 2017 114 (13) 3533-3538; first published March 13, 2017. https://doi.org/10.1073/pnas.1615005114
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    Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness

    Jun-Jie Ling, Jian Li, Danmeng Zhu, and Xing Wang Deng

    PNAS March 28, 2017 114 (13) 3539-3544; first published March 14, 2017. https://doi.org/10.1073/pnas.1700850114