Table of Contents

Biological Sciences

• Agricultural Sciences

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    Intensified agriculture favors evolved resistance to biological control

    • From the Cover

    Federico Tomasetto, Jason M. Tylianakis, Marco Reale, Steve Wratten, and Stephen L. Goldson

    PNAS April 11, 2017 114 (15) 3885-3890; first published March 13, 2017. https://doi.org/10.1073/pnas.1618416114

    See companion article:

    • Evolution of resistance in biological control

      - Mar 24, 2017

• Applied Biological Sciences

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    High-throughput identification of small molecules that affect human embryonic vascular development

    Helena Vazão, Susana Rosa, Tânia Barata, Ricardo Costa, Patrícia R. Pitrez, Inês Honório, Margreet R. de Vries, Dimitri Papatsenko, Rui Benedito, Daniel Saris, Ali Khademhosseini, Paul H. A. Quax, Carlos F. Pereira, Nadia Mercader, Hugo Fernandes, and Lino Ferreira

    PNAS April 11, 2017 114 (15) E3022-E3031; first published March 27, 2017. https://doi.org/10.1073/pnas.1617451114

• Biochemistry

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    Mechanism of transcription initiation and promoter escape by E. coli RNA polymerase

    Kate L. Henderson, Lindsey C. Felth, Cristen M. Molzahn, Irina Shkel, Si Wang, Munish Chhabra, Emily F. Ruff, Lauren Bieter, Joseph E. Kraft, and M. Thomas Record Jr.

    PNAS April 11, 2017 114 (15) E3032-E3040; first published March 27, 2017. https://doi.org/10.1073/pnas.1618675114
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    PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation

    Rui Wu, Ruslan Sanishvili, Boris R. Belitsky, Jose I. Juncosa, Hoang V. Le, Helaina J. S. Lehrer, Michael Farley, Richard B. Silverman, Gregory A. Petsko, Dagmar Ringe, and Dali Liu

    PNAS April 11, 2017 114 (15) 3891-3896; first published March 27, 2017. https://doi.org/10.1073/pnas.1703019114

• Biophysics and Computational Biology

  • Open Access

    Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48

    Blas Moreno-Beltrán, Alejandra Guerra-Castellano, Antonio Díaz-Quintana, Rebecca Del Conte, Sofía M. García-Mauriño, Sofía Díaz-Moreno, Katiuska González-Arzola, Carlos Santos-Ocaña, Adrián Velázquez-Campoy, Miguel A. De la Rosa, Paola Turano, and Irene Díaz-Moreno

    PNAS April 11, 2017 114 (15) E3041-E3050; first published March 27, 2017. https://doi.org/10.1073/pnas.1618008114
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    Structures of closed and open states of a voltage-gated sodium channel

    Michael J. Lenaeus, Tamer M. Gamal El-Din, Christopher Ing, Karthik Ramanadane, Régis Pomès, Ning Zheng, and William A. Catterall

    PNAS April 11, 2017 114 (15) E3051-E3060; first published March 27, 2017. https://doi.org/10.1073/pnas.1700761114
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    Highly oriented photosynthetic reaction centers generate a proton gradient in synthetic protocells

    • From the Cover

    Emiliano Altamura, Francesco Milano, Roberto R. Tangorra, Massimo Trotta, Omar Hassan Omar, Pasquale Stano, and Fabio Mavelli

    PNAS April 11, 2017 114 (15) 3837-3842; first published March 20, 2017. https://doi.org/10.1073/pnas.1617593114

    See companion article:

    • Design of energy-transducing artificial cells

      - Mar 30, 2017
  • Open Access

    Frequency and potential dependence of reversible electrocatalytic hydrogen interconversion by [FeFe]-hydrogenases

    Kavita Pandey, Shams T. A. Islam, Thomas Happe, and Fraser A. Armstrong

    PNAS April 11, 2017 114 (15) 3843-3848; first published March 27, 2017. https://doi.org/10.1073/pnas.1619961114
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    Structural reconstruction of protein ancestry

    Romain Rouet, David B. Langley, Peter Schofield, Mary Christie, Brendan Roome, Benjamin T. Porebski, Ashley M. Buckle, Ben E. Clifton, Colin J. Jackson, Daniela Stock, and Daniel Christ

    PNAS April 11, 2017 114 (15) 3897-3902; first published March 29, 2017. https://doi.org/10.1073/pnas.1613477114

• Cell Biology

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    Form and function of topologically associating genomic domains in budding yeast

    Umut Eser, Devon Chandler-Brown, Ferhat Ay, Aaron F. Straight, Zhijun Duan, William Stafford Noble, and Jan M. Skotheim

    PNAS April 11, 2017 114 (15) E3061-E3070; first published March 27, 2017. https://doi.org/10.1073/pnas.1612256114
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    Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c

    Dan Luo, Antoine de Morree, Stephane Boutet, Navaline Quach, Vanita Natu, Arjun Rustagi, and Thomas A. Rando

    PNAS April 11, 2017 114 (15) E3071-E3080; first published March 28, 2017. https://doi.org/10.1073/pnas.1613592114
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    High-numerical-aperture cryogenic light microscopy for increased precision of superresolution reconstructions

    Marc Nahmani, Conor Lanahan, David DeRosier, and Gina G. Turrigiano

    PNAS April 11, 2017 114 (15) 3832-3836; first published March 27, 2017. https://doi.org/10.1073/pnas.1618206114
  • Open Access

    Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

    Zhen Zhang, Kim Newton, Sarah K. Kummerfeld, Joshua Webster, Donald S. Kirkpatrick, Lilian Phu, Jeffrey Eastham-Anderson, Jinfeng Liu, Wyne P. Lee, Jiansheng Wu, Hong Li, Melissa R. Junttila, and Vishva M. Dixit

    PNAS April 11, 2017 114 (15) 3903-3908; first published March 28, 2017. https://doi.org/10.1073/pnas.1621177114
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    ERRα induces H3K9 demethylation by LSD1 to promote cell invasion

    Julie Carnesecchi, Christelle Forcet, Ling Zhang, Violaine Tribollet, Bruno Barenton, Rafik Boudra, Catherine Cerutti, Isabelle M. L. Billas, Aurélien A. Sérandour, Jason S. Carroll, Claude Beaudoin, and Jean-Marc Vanacker

    PNAS April 11, 2017 114 (15) 3909-3914; first published March 27, 2017. https://doi.org/10.1073/pnas.1614664114
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    MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells

    Andrew B. E. Brooks, Daniel Humphreys, Vikash Singh, Anthony C. Davidson, Susan D. Arden, Folma Buss, and Vassilis Koronakis

    PNAS April 11, 2017 114 (15) 3915-3920; first published March 27, 2017. https://doi.org/10.1073/pnas.1616418114
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    Splicing variation of Long-IRBIT determines the target selectivity of IRBIT family proteins

    Katsuhiro Kawaai, Hideaki Ando, Nobuhiko Satoh, Hideomi Yamada, Naoko Ogawa, Matsumi Hirose, Akihiro Mizutani, Benjamin Bonneau, George Seki, and Katsuhiko Mikoshiba

    PNAS April 11, 2017 114 (15) 3921-3926; first published March 27, 2017. https://doi.org/10.1073/pnas.1618514114
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    Identification of targets of tumor suppressor microRNA-34a using a reporter library system

    Yoshiaki Ito, Atsushi Inoue, Timothy Seers, Yukari Hato, Arisa Igarashi, Tatsuya Toyama, Konstantin D. Taganov, Mark P. Boldin, and Hiroshi Asahara

    PNAS April 11, 2017 114 (15) 3927-3932; first published March 29, 2017. https://doi.org/10.1073/pnas.1620019114
  • Open Access

    Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix

    Joel B. Heim, Edwin J. Squirewell, Ancilla Neu, Georg Zocher, Sindhuja Sominidi-Damodaran, Saranya P. Wyles, Ekaterina Nikolova, Nille Behrendt, Ditte M. Saunte, Jorgen Lock-Andersen, Krutika S. Gaonkar, Huihuang Yan, Jann N. Sarkaria, Mira Krendel, Jan van Deursen, Remco Sprangers, Thilo Stehle, Ralph T. Böttcher, Jeong-Heon Lee, Tamas Ordog, and Alexander Meves

    PNAS April 11, 2017 114 (15) 3933-3938; first published March 27, 2017. https://doi.org/10.1073/pnas.1614894114

• Developmental Biology

  • Open Access

    Spemann organizer transcriptome induction by early beta-catenin, Wnt, Nodal, and Siamois signals in Xenopus laevis

    Yi Ding, Diego Ploper, Eric A. Sosa, Gabriele Colozza, Yuki Moriyama, Maria D. J. Benitez, Kelvin Zhang, Daria Merkurjev, and Edward M. De Robertis

    PNAS April 11, 2017 114 (15) E3081-E3090; first published March 27, 2017. https://doi.org/10.1073/pnas.1700766114
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    AMPA glutamate receptors are required for sensory-organ formation and morphogenesis in the basal chordate

    Shinobu Hirai, Kohji Hotta, Yoshihiro Kubo, Atsuo Nishino, Shigeo Okabe, Yasushi Okamura, and Haruo Okado

    PNAS April 11, 2017 114 (15) 3939-3944; first published March 27, 2017. https://doi.org/10.1073/pnas.1612943114

• Environmental Sciences

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    Range contraction enables harvesting to extinction

    • From the Cover

    Matthew G. Burgess, Christopher Costello, Alexa Fredston-Hermann, Malin L. Pinsky, Steven D. Gaines, David Tilman, and Stephen Polasky

    PNAS April 11, 2017 114 (15) 3945-3950; first published March 28, 2017. https://doi.org/10.1073/pnas.1607551114

    See companion article:

    • Management is key to preventing marine extinctions

      - Jul 18, 2017

• Evolution

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    Partner abundance controls mutualism stability and the pace of morphological change over geologic time

    Guillaume Chomicki and Susanne S. Renner

    PNAS April 11, 2017 114 (15) 3951-3956; first published March 24, 2017. https://doi.org/10.1073/pnas.1616837114
  • Open Access

    Metabolic evolution and the self-organization of ecosystems

    Rogier Braakman, Michael J. Follows, and Sallie W. Chisholm

    PNAS April 11, 2017 114 (15) E3091-E3100; first published March 27, 2017. https://doi.org/10.1073/pnas.1619573114

• Genetics

  • Open Access

    Mutational spectra of aflatoxin B₁ in vivo establish biomarkers of exposure for human hepatocellular carcinoma

    Supawadee Chawanthayatham, Charles C. Valentine III, Bogdan I. Fedeles, Edward J. Fox, Lawrence A. Loeb, Stuart S. Levine, Stephen L. Slocum, Gerald N. Wogan, Robert G. Croy, and John M. Essigmann

    PNAS April 11, 2017 114 (15) E3101-E3109; first published March 28, 2017. https://doi.org/10.1073/pnas.1700759114

• Immunology and Inflammation

  • Open Access

    Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms

    Carlos G. Briseño, Marco Gargaro, Vivek Durai, Jesse T. Davidson, Derek J. Theisen, David A. Anderson III, Deborah V. Novack, Theresa L. Murphy, and Kenneth M. Murphy

    PNAS April 11, 2017 114 (15) 3957-3962; first published March 27, 2017. https://doi.org/10.1073/pnas.1619863114
  • Open Access

    Protectin D1_{n-3 DPA} and resolvin D5_{n-3 DPA} are effectors of intestinal protection

    Thomas Gobbetti, Jesmond Dalli, Romain A. Colas, Donata Federici Canova, Marius Aursnes, Delphine Bonnet, Laurent Alric, Nathalie Vergnolle, Celine Deraison, Trond V. Hansen, Charles N. Serhan, and Mauro Perretti

    PNAS April 11, 2017 114 (15) 3963-3968; first published March 29, 2017. https://doi.org/10.1073/pnas.1617290114

• Medical Sciences

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    Efficacy, long-term toxicity, and mechanistic studies of gold nanorods photothermal therapy of cancer in xenograft mice

    Moustafa R. K. Ali, Mohammad Aminur Rahman, Yue Wu, Tiegang Han, Xianghong Peng, Megan A. Mackey, Dongsheng Wang, Hyung Ju Shin, Zhuo G. Chen, Haopeng Xiao, Ronghu Wu, Yan Tang, Dong M. Shin, and Mostafa A. El-Sayed

    PNAS April 11, 2017 114 (15) E3110-E3118; first published March 29, 2017. https://doi.org/10.1073/pnas.1619302114
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    Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

    Kun Li, Christine L. Wohlford-Lenane, Rudragouda Channappanavar, Jung-Eun Park, James T. Earnest, Thomas B. Bair, Amber M. Bates, Kim A. Brogden, Heather A. Flaherty, Tom Gallagher, David K. Meyerholz, Stanley Perlman, and Paul B. McCray Jr.

    PNAS April 11, 2017 114 (15) E3119-E3128; first published March 27, 2017. https://doi.org/10.1073/pnas.1619109114
  • Open Access

    Quantification of circulating Mycobacterium tuberculosis antigen peptides allows rapid diagnosis of active disease and treatment monitoring

    Chang Liu, Zhen Zhao, Jia Fan, Christopher J. Lyon, Hung-Jen Wu, Dobrin Nedelkov, Adrian M. Zelazny, Kenneth N. Olivier, Lisa H. Cazares, Steven M. Holland, Edward A. Graviss, and Ye Hu

    PNAS April 11, 2017 114 (15) 3969-3974; first published March 27, 2017. https://doi.org/10.1073/pnas.1621360114
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    Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations

    Jing Chen, Yong Zhang, Michael N. Petrus, Wenming Xiao, Alina Nicolae, Mark Raffeld, Stefania Pittaluga, Richard N. Bamford, Masao Nakagawa, Sunny Tianyi Ouyang, Alan L. Epstein, Marshall E. Kadin, Annarose Del Mistro, Richard Woessner, Elaine S. Jaffe, and Thomas A. Waldmann

    PNAS April 11, 2017 114 (15) 3975-3980; first published March 29, 2017. https://doi.org/10.1073/pnas.1700682114
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    BCL6 promotes glioma and serves as a therapeutic target

    Liang Xu, Ye Chen, Marina Dutra-Clarke, Anand Mayakonda, Masaharu Hazawa, Steve E. Savinoff, Ngan Doan, Jonathan W. Said, William H. Yong, Ashley Watkins, Henry Yang, Ling-Wen Ding, Yan-Yi Jiang, Jeffrey W. Tyner, Jianhong Ching, Jean-Paul Kovalik, Vikas Madan, Shing-Leng Chan, Markus Müschen, Joshua J. Breunig, De-Chen Lin, and H. Phillip Koeffler

    PNAS April 11, 2017 114 (15) 3981-3986; first published March 29, 2017. https://doi.org/10.1073/pnas.1609758114
  • Open Access

    Complement modulation in the retinal pigment epithelium rescues photoreceptor degeneration in a mouse model of Stargardt disease

    Tamara L. Lenis, Shanta Sarfare, Zhichun Jiang, Marcia B. Lloyd, Dean Bok, and Roxana A. Radu

    PNAS April 11, 2017 114 (15) 3987-3992; first published March 27, 2017. https://doi.org/10.1073/pnas.1620299114
  • Open Access

    Endothelial transcription factor KLF2 negatively regulates liver regeneration via induction of activin A

    Yosif Manavski, Tobias Abel, Junhao Hu, Dina Kleinlützum, Christian J. Buchholz, Christina Belz, Hellmut G. Augustin, Reinier A. Boon, and Stefanie Dimmeler

    PNAS April 11, 2017 114 (15) 3993-3998; first published March 27, 2017. https://doi.org/10.1073/pnas.1613392114

• Neuroscience

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    ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease

    Bo-Jeng Wang, Guor Mour Her, Ming-Kuan Hu, Yun-Wen Chen, Ying-Tsen Tung, Pei-Yi Wu, Wen-Ming Hsu, Hsinyu Lee, Lee-Way Jin, Sheng-Ping L. Hwang, Rita P.-Y. Chen, Chang-Jen Huang, and Yung-Feng Liao

    PNAS April 11, 2017 114 (15) E3129-E3138; first published March 28, 2017. https://doi.org/10.1073/pnas.1618804114
  • Open Access

    Transfer of pathogenic and nonpathogenic cytosolic proteins between spinal cord motor neurons in vivo in chimeric mice

    Eleanor V. Thomas, Wayne A. Fenton, James McGrath, and Arthur L. Horwich

    PNAS April 11, 2017 114 (15) E3139-E3148; first published March 27, 2017. https://doi.org/10.1073/pnas.1701465114
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    Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease

    • From the Cover

    Athanasios D. Spathis, Xenophon Asvos, Despina Ziavra, Theodoros Karampelas, Stavros Topouzis, Zoe Cournia, Xiaobing Qing, Pavlos Alexakos, Lisa M. Smits, Christina Dalla, Hardy J. Rideout, Jens Christian Schwamborn, Constantin Tamvakopoulos, Demosthenes Fokas, and Demetrios K. Vassilatis

    PNAS April 11, 2017 114 (15) 3999-4004; first published March 27, 2017. https://doi.org/10.1073/pnas.1616874114

    See companion article:

    • Toward neuroprotective treatments of PD

      - Mar 30, 2017

• Plant Biology

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    Long noncoding miRNA gene represses wheat β-diketone waxes

    Daiqing Huang, J. Allan Feurtado, Mark A. Smith, Leah K. Flatman, Chushin Koh, and Adrian J. Cutler

    PNAS April 11, 2017 114 (15) E3149-E3158; first published March 28, 2017. https://doi.org/10.1073/pnas.1617483114
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    Symplastic communication spatially directs local auxin biosynthesis to maintain root stem cell niche in Arabidopsis

    Yuting Liu, Meizhi Xu, Nengsong Liang, Yanghang Zheng, Qiaozhi Yu, and Shuang Wu

    PNAS April 11, 2017 114 (15) 4005-4010; first published March 27, 2017. https://doi.org/10.1073/pnas.1616387114
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    KETCH1 imports HYL1 to nucleus for miRNA biogenesis in Arabidopsis

    Zhonghui Zhang, Xinwei Guo, Chunxiao Ge, Zeyang Ma, Mengqiu Jiang, Tianhong Li, Hisashi Koiwa, Seong Wook Yang, and Xiuren Zhang

    PNAS April 11, 2017 114 (15) 4011-4016; first published March 27, 2017. https://doi.org/10.1073/pnas.1619755114

• Population Biology

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    Effectiveness of UNAIDS targets and HIV vaccination across 127 countries

    • From the Cover

    Jan Medlock, Abhishek Pandey, Alyssa S. Parpia, Amber Tang, Laura A. Skrip, and Alison P. Galvani

    PNAS April 11, 2017 114 (15) 4017-4022; first published March 20, 2017. https://doi.org/10.1073/pnas.1620788114

    See companion article:

    • Preventing HIV acquisition

      - Mar 30, 2017
  • Open Access

    Comparing nonpharmaceutical interventions for containing emerging epidemics

    Corey M. Peak, Lauren M. Childs, Yonatan H. Grad, and Caroline O. Buckee

    PNAS April 11, 2017 114 (15) 4023-4028; first published March 28, 2017. https://doi.org/10.1073/pnas.1616438114