Table of Contents

Biological Sciences

• Biochemistry

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    The cryo-EM structure of YjeQ bound to the 30S subunit suggests a fidelity checkpoint function for this protein in ribosome assembly

    Aida Razi, Alba Guarné, and Joaquin Ortega

    PNAS April 25, 2017 114 (17) E3396-E3403; first published April 10, 2017. https://doi.org/10.1073/pnas.1618016114
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    Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c

    Chueh-Ling Kuo and Alfred Lewis Goldberg

    PNAS April 25, 2017 114 (17) E3404-E3413; first published April 10, 2017. https://doi.org/10.1073/pnas.1701734114
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    Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids

    Amy A. Rand, Bogdan Barnych, Christophe Morisseau, Tomas Cajka, Kin Sing Stephen Lee, Dipak Panigrahy, and Bruce D. Hammock

    PNAS April 25, 2017 114 (17) 4370-4375; first published April 10, 2017. https://doi.org/10.1073/pnas.1616893114
  • Open Access

    Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization

    Veli-Matti Leppänen, Pipsa Saharinen, and Kari Alitalo

    PNAS April 25, 2017 114 (17) 4376-4381; first published April 10, 2017. https://doi.org/10.1073/pnas.1616166114

    See companion article:

    • Ligand-independent dimerization of Tie2

      - Apr 10, 2017
  • Open Access

    Dimerization of Tie2 mediated by its membrane-proximal FNIII domains

    Jason O. Moore, Mark A. Lemmon, and Kathryn M. Ferguson

    PNAS April 25, 2017 114 (17) 4382-4387; first published April 10, 2017. https://doi.org/10.1073/pnas.1617800114

    See companion article:

    • Tie2 activation and Tie2/Tie1 heterodimerization

      - Apr 10, 2017
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    Proteolytic control of the mitochondrial calcium uniporter complex

    Chen-Wei Tsai, Yujiao Wu, Ping-Chieh Pao, Charles B. Phillips, Carole Williams, Christopher Miller, Matthew Ranaghan, and Ming-Feng Tsai

    PNAS April 25, 2017 114 (17) 4388-4393; first published April 10, 2017. https://doi.org/10.1073/pnas.1702938114
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    Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance

    Yixuan Wu, Todd R. Albrecht, David Baillat, Eric J. Wagner, and Liang Tong

    PNAS April 25, 2017 114 (17) 4394-4399; first published April 10, 2017. https://doi.org/10.1073/pnas.1616605114
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    Structure of a DNA glycosylase that unhooks interstrand cross-links

    Elwood A. Mullins, Garrett M. Warren, Noah P. Bradley, and Brandt F. Eichman

    PNAS April 25, 2017 114 (17) 4400-4405; first published April 10, 2017. https://doi.org/10.1073/pnas.1703066114

• Biophysics and Computational Biology

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    Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity

    George P. Lisi, Kyle W. East, Victor S. Batista, and J. Patrick Loria

    PNAS April 25, 2017 114 (17) E3414-E3423; first published April 10, 2017. https://doi.org/10.1073/pnas.1700448114
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    Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington’s disease

    Mingchen Chen and Peter G. Wolynes

    PNAS April 25, 2017 114 (17) 4406-4411; first published April 11, 2017. https://doi.org/10.1073/pnas.1702237114
  • Open Access

    In situ structural studies of tripeptidyl peptidase II (TPPII) reveal spatial association with proteasomes

    Yoshiyuki Fukuda, Florian Beck, Jürgen M. Plitzko, and Wolfgang Baumeister

    PNAS April 25, 2017 114 (17) 4412-4417; first published April 10, 2017. https://doi.org/10.1073/pnas.1701367114
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    Balance of microtubule stiffness and cortical tension determines the size of blood cells with marginal band across species

    Serge Dmitrieff, Adolfo Alsina, Aastha Mathur, and François J. Nédélec

    PNAS April 25, 2017 114 (17) 4418-4423; first published April 11, 2017. https://doi.org/10.1073/pnas.1618041114
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    Entropy redistribution controls allostery in a metalloregulatory protein

    • From the Cover

    Daiana A. Capdevila, Joseph J. Braymer, Katherine A. Edmonds, Hongwei Wu, and David P. Giedroc

    PNAS April 25, 2017 114 (17) 4424-4429; first published March 27, 2017. https://doi.org/10.1073/pnas.1620665114

    See companion article:

    • Conformational entropy and motion in allostery

      - Apr 18, 2017
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    CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel

    Zachary M. James, Andrew J. Borst, Yoni Haitin, Brandon Frenz, Frank DiMaio, William N. Zagotta, and David Veesler

    PNAS April 25, 2017 114 (17) 4430-4435; first published April 10, 2017. https://doi.org/10.1073/pnas.1700248114

• Cell Biology

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    SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

    Deokjae Lee, Jungeun An, Young-Un Park, Hungjiun Liaw, Roger Woodgate, Jun Hong Park, and Kyungjae Myung

    PNAS April 25, 2017 114 (17) E3424-E3433; first published April 11, 2017. https://doi.org/10.1073/pnas.1701978114
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    PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

    Nina Ilic, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory, Michael E. Pacold, Shambhavi Singh, Susan E. Moody, Joseph D. DeAngelo, Nicole A. Spardy, Elizaveta Freinkman, Barbara A. Weir, Aviad Tsherniak, Glenn S. Cowley, David E. Root, John M. Asara, Francisca Vazquez, Hans R. Widlund, David M. Sabatini, and William C. Hahn

    PNAS April 25, 2017 114 (17) E3434-E3443; first published April 10, 2017. https://doi.org/10.1073/pnas.1617922114
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    Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma

    Arvin M. Gouw, Livia S. Eberlin, Katherine Margulis, Delaney K. Sullivan, Georgia G. Toal, Ling Tong, Richard N. Zare, and Dean W. Felsher

    PNAS April 25, 2017 114 (17) 4300-4305; first published April 11, 2017. https://doi.org/10.1073/pnas.1617709114

• Ecology

  • Open Access

    El Niño and the shifting geography of cholera in Africa

    Sean M. Moore, Andrew S. Azman, Benjamin F. Zaitchik, Eric D. Mintz, Joan Brunkard, Dominique Legros, Alexandra Hill, Heather McKay, Francisco J. Luquero, David Olson, and Justin Lessler

    PNAS April 25, 2017 114 (17) 4436-4441; first published April 10, 2017. https://doi.org/10.1073/pnas.1617218114
  • Open Access

    Floodplains as an Achilles’ heel of Amazonian forest resilience

    Bernardo M. Flores, Milena Holmgren, Chi Xu, Egbert H. van Nes, Catarina C. Jakovac, Rita C. G. Mesquita, and Marten Scheffer

    PNAS April 25, 2017 114 (17) 4442-4446; first published April 10, 2017. https://doi.org/10.1073/pnas.1617988114

    See companion article:

    • Forest resilience across Amazonian floodplains

      - Sep 27, 2017
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    Experimental dispersal reveals characteristic scales of biodiversity in a natural landscape

    Rachel M. Germain, Sharon Y. Strauss, and Benjamin Gilbert

    PNAS April 25, 2017 114 (17) 4447-4452; first published April 17, 2017. https://doi.org/10.1073/pnas.1615338114

• Environmental Sciences

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    Role of surface and subsurface processes in scaling N₂O emissions along riverine networks

    Alessandra Marzadri, Martha M. Dee, Daniele Tonina, Alberto Bellin, and Jennifer L. Tank

    PNAS April 25, 2017 114 (17) 4330-4335; first published April 11, 2017. https://doi.org/10.1073/pnas.1617454114
  • Open Access

    Salting our freshwater lakes

    Hilary A. Dugan, Sarah L. Bartlett, Samantha M. Burke, Jonathan P. Doubek, Flora E. Krivak-Tetley, Nicholas K. Skaff, Jamie C. Summers, Kaitlin J. Farrell, Ian M. McCullough, Ana M. Morales-Williams, Derek C. Roberts, Zutao Ouyang, Facundo Scordo, Paul C. Hanson, and Kathleen C. Weathers

    PNAS April 25, 2017 114 (17) 4453-4458; first published April 10, 2017. https://doi.org/10.1073/pnas.1620211114

• Evolution

  • Open Access

    Uplift-driven diversification in the Hengduan Mountains, a temperate biodiversity hotspot

    • From the Cover

    Yaowu Xing and Richard H. Ree

    PNAS April 25, 2017 114 (17) E3444-E3451; first published April 3, 2017. https://doi.org/10.1073/pnas.1616063114

    See companion article:

    • Evolution of biodiversity hotspots

      - Apr 17, 2017
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    Mechanosensation is evolutionarily tuned to locomotor mechanics

    Brett R. Aiello, Mark W. Westneat, and Melina E. Hale

    PNAS April 25, 2017 114 (17) 4459-4464; first published April 10, 2017. https://doi.org/10.1073/pnas.1616839114
  • Open Access

    Determining the factors driving selective effects of new nonsynonymous mutations

    Christian D. Huber, Bernard Y. Kim, Clare D. Marsden, and Kirk E. Lohmueller

    PNAS April 25, 2017 114 (17) 4465-4470; first published April 11, 2017. https://doi.org/10.1073/pnas.1619508114

• Genetics

  • Open Access

    Parallel adaptive evolution of geographically distant herring populations on both sides of the North Atlantic Ocean

    Sangeet Lamichhaney, Angela P. Fuentes-Pardo, Nima Rafati, Nils Ryman, Gregory R. McCracken, Christina Bourne, Rabindra Singh, Daniel E. Ruzzante, and Leif Andersson

    PNAS April 25, 2017 114 (17) E3452-E3461; first published April 7, 2017. https://doi.org/10.1073/pnas.1617728114
  • Open Access

    Mutation in sorghum LOW GERMINATION STIMULANT 1 alters strigolactones and causes Striga resistance

    Daniel Gobena, Mahdere Shimels, Patrick J. Rich, Carolien Ruyter-Spira, Harro Bouwmeester, Satish Kanuganti, Tesfaye Mengiste, and Gebisa Ejeta

    PNAS April 25, 2017 114 (17) 4471-4476; first published April 10, 2017. https://doi.org/10.1073/pnas.1618965114

• Immunology and Inflammation

  • Open Access

    Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M

    Marianne D. Hansen, Ingvild B. Johnsen, Kim A. Stiberg, Tatyana Sherstova, Takaji Wakita, Gabriel Mary Richard, Richard K. Kandasamy, Eliane F. Meurs, and Marit W. Anthonsen

    PNAS April 25, 2017 114 (17) E3462-E3471; first published April 7, 2017. https://doi.org/10.1073/pnas.1616683114
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    Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity

    David Zemmour, Alvin Pratama, Scott M. Loughhead, Diane Mathis, and Christophe Benoist

    PNAS April 25, 2017 114 (17) E3472-E3480; first published April 10, 2017. https://doi.org/10.1073/pnas.1700946114
  • Open Access

    Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling

    Sam Strickson, Christoph H. Emmerich, Eddy T. H. Goh, Jiazhen Zhang, Ian R. Kelsall, Thomas Macartney, C. James Hastie, Axel Knebel, Mark Peggie, Francesco Marchesi, J. Simon C. Arthur, and Philip Cohen

    PNAS April 25, 2017 114 (17) E3481-E3489; first published April 12, 2017. https://doi.org/10.1073/pnas.1702367114
  • Open Access

    Antigenicity-defined conformations of an extremely neutralization-resistant HIV-1 envelope spike

    Yongfei Cai, Selen Karaca-Griffin, Jia Chen, Sai Tian, Nicholas Fredette, Christine E. Linton, Sophia Rits-Volloch, Jianming Lu, Kshitij Wagh, James Theiler, Bette Korber, Michael S. Seaman, Stephen C. Harrison, Andrea Carfi, and Bing Chen

    PNAS April 25, 2017 114 (17) 4477-4482; first published April 10, 2017. https://doi.org/10.1073/pnas.1700634114
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    Endotoxin-induced autocrine ATP signaling inhibits neutrophil chemotaxis through enhancing myosin light chain phosphorylation

    Xu Wang, Weiting Qin, Xiaohan Xu, Yuyun Xiong, Yisen Zhang, Huafeng Zhang, and Bingwei Sun

    PNAS April 25, 2017 114 (17) 4483-4488; first published April 10, 2017. https://doi.org/10.1073/pnas.1616752114

• Medical Sciences

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    Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects

    Zhiyong Zhao, Lixue Cao, and E. Albert Reece

    PNAS April 25, 2017 114 (17) 4489-4494; first published April 10, 2017. https://doi.org/10.1073/pnas.1616119114

• Microbiology

  • Open Access

    Plasma fibronectin stabilizes Borrelia burgdorferi–endothelial interactions under vascular shear stress by a catch-bond mechanism

    Alexandra F. Niddam, Rhodaba Ebady, Anil Bansal, Anne Koehler, Boris Hinz, and Tara J. Moriarty

    PNAS April 25, 2017 114 (17) E3490-E3498; first published April 10, 2017. https://doi.org/10.1073/pnas.1615007114
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    SAGA complex mediates the transcriptional up-regulation of antiviral RNA silencing

    Ida Bagus Andika, Atif Jamal, Hideki Kondo, and Nobuhiro Suzuki

    PNAS April 25, 2017 114 (17) E3499-E3506; first published April 11, 2017. https://doi.org/10.1073/pnas.1701196114
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    Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis

    Catherine Vilchèze, Travis Hartman, Brian Weinrick, Paras Jain, Torin R. Weisbrod, Lawrence W. Leung, Joel S. Freundlich, and William R. Jacobs Jr.

    PNAS April 25, 2017 114 (17) 4495-4500; first published April 10, 2017. https://doi.org/10.1073/pnas.1704376114
  • Open Access

    Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes

    Chao Chen, Lianrong Wang, Si Chen, Xiaolin Wu, Meijia Gu, Xi Chen, Susu Jiang, Yunfu Wang, Zixin Deng, Peter C. Dedon, and Shi Chen

    PNAS April 25, 2017 114 (17) 4501-4506; first published April 11, 2017. https://doi.org/10.1073/pnas.1702450114
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    Enterococcus faecalis bacteriocin EntV inhibits hyphal morphogenesis, biofilm formation, and virulence of Candida albicans

    Carrie E. Graham, Melissa R. Cruz, Danielle A. Garsin, and Michael C. Lorenz

    PNAS April 25, 2017 114 (17) 4507-4512; first published April 10, 2017. https://doi.org/10.1073/pnas.1620432114

• Neuroscience

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    Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain

    Catharina Reimers, Cheng-Han Lee, Hubert Kalbacher, Yuemin Tian, Chih-Hsien Hung, Axel Schmidt, Lea Prokop, Silke Kauferstein, Dietrich Mebs, Chih-Cheng Chen, and Stefan Gründer

    PNAS April 25, 2017 114 (17) E3507-E3515; first published April 10, 2017. https://doi.org/10.1073/pnas.1616232114
  • Open Access

    Context-dependent spatially periodic activity in the human entorhinal cortex

    Zoltan Nadasdy, T. Peter Nguyen, Ágoston Török, Jason Y. Shen, Deborah E. Briggs, Pradeep N. Modur, and Robert J. Buchanan

    PNAS April 25, 2017 114 (17) E3516-E3525; first published April 10, 2017. https://doi.org/10.1073/pnas.1701352114
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    Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity

    Emi Hasegawa, Takashi Maejima, Takayuki Yoshida, Olivia A. Masseck, Stefan Herlitze, Mitsuhiro Yoshioka, Takeshi Sakurai, and Michihiro Mieda

    PNAS April 25, 2017 114 (17) E3526-E3535; first published April 10, 2017. https://doi.org/10.1073/pnas.1614552114
  • Open Access

    Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus

    Qianfa Long, Dinesh Upadhya, Bharathi Hattiangady, Dong-Ki Kim, Su Yeon An, Bing Shuai, Darwin J. Prockop, and Ashok K. Shetty

    PNAS April 25, 2017 114 (17) E3536-E3545; first published April 10, 2017. https://doi.org/10.1073/pnas.1703920114
  • Open Access

    APC/C^Cdh1-Rock2 pathway controls dendritic integrity and memory

    Verónica Bobo-Jiménez, María Delgado-Esteban, Julie Angibaud, Irene Sánchez-Morán, Antonio de la Fuente, Javier Yajeya, U. Valentin Nägerl, José Castillo, Juan P. Bolaños, and Angeles Almeida

    PNAS April 25, 2017 114 (17) 4513-4518; first published April 10, 2017. https://doi.org/10.1073/pnas.1616024114
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    Selective entrainment of gamma subbands by different slow network oscillations

    Weiwei Zhong, Mareva Ciatipis, Thérèse Wolfenstetter, Jakob Jessberger, Carola Müller, Simon Ponsel, Yevgenij Yanovsky, Jurij Brankačk, Adriano B. L. Tort, and Andreas Draguhn

    PNAS April 25, 2017 114 (17) 4519-4524; first published April 10, 2017. https://doi.org/10.1073/pnas.1617249114
  • Open Access

    Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice

    Christin Kosse, Cornelia Schöne, Edward Bracey, and Denis Burdakov

    PNAS April 25, 2017 114 (17) 4525-4530; first published April 10, 2017. https://doi.org/10.1073/pnas.1619700114

• Pharmacology

  • Open Access

    Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

    Keisuke Yanagida, Catherine H. Liu, Giuseppe Faraco, Sylvain Galvani, Helen K. Smith, Nathalie Burg, Josef Anrather, Teresa Sanchez, Costantino Iadecola, and Timothy Hla

    PNAS April 25, 2017 114 (17) 4531-4536; first published April 10, 2017. https://doi.org/10.1073/pnas.1618659114

• Physiology

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    Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors

    Joshua Levitz, Johannes Broichhagen, Philipp Leippe, David Konrad, Dirk Trauner, and Ehud Y. Isacoff

    PNAS April 25, 2017 114 (17) E3546-E3554; first published April 10, 2017. https://doi.org/10.1073/pnas.1619652114

• Plant Biology

  • Open Access

    PIF4-controlled auxin pathway contributes to hybrid vigor in Arabidopsis thaliana

    Li Wang, Li Min Wu, Ian K. Greaves, Anyu Zhu, Elizabeth S. Dennis, and W. James Peacock

    PNAS April 25, 2017 114 (17) E3555-E3562; first published April 10, 2017. https://doi.org/10.1073/pnas.1703179114
  • Open Access

    Malate-dependent Fe accumulation is a critical checkpoint in the root developmental response to low phosphate

    Javier Mora-Macías, Jonathan Odilón Ojeda-Rivera, Dolores Gutiérrez-Alanís, Lenin Yong-Villalobos, Araceli Oropeza-Aburto, Javier Raya-González, Gabriel Jiménez-Domínguez, Gabriela Chávez-Calvillo, Rubén Rellán-Álvarez, and Luis Herrera-Estrella

    PNAS April 25, 2017 114 (17) E3563-E3572; first published April 11, 2017. https://doi.org/10.1073/pnas.1701952114
  • Open Access

    The carbonic anhydrase CAH1 is an essential component of the carbon-concentrating mechanism in Nannochloropsis oceanica

    Christopher W. Gee and Krishna K. Niyogi

    PNAS April 25, 2017 114 (17) 4537-4542; first published April 10, 2017. https://doi.org/10.1073/pnas.1700139114
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    Ploidy-dependent changes in the epigenome of symbiotic cells correlate with specific patterns of gene expression

    Marianna Nagymihály, Alaguraj Veluchamy, Zoltán Györgypál, Federico Ariel, Teddy Jégu, Moussa Benhamed, Attila Szűcs, Attila Kereszt, Peter Mergaert, and Éva Kondorosi

    PNAS April 25, 2017 114 (17) 4543-4548; first published April 12, 2017. https://doi.org/10.1073/pnas.1704211114
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    Live imaging of root–bacteria interactions in a microfluidics setup

    • From the Cover

    Hassan Massalha, Elisa Korenblum, Sergey Malitsky, Orr H. Shapiro, and Asaph Aharoni

    PNAS April 25, 2017 114 (17) 4549-4554; first published March 27, 2017. https://doi.org/10.1073/pnas.1618584114

    See companion article:

    • Mapping plant root interactions

      - Apr 04, 2017

• Psychological and Cognitive Sciences

  • Open Access

    Variations in crowding, saccadic precision, and spatial localization reveal the shared topology of spatial vision

    John A. Greenwood, Martin Szinte, Bilge Sayim, and Patrick Cavanagh

    PNAS April 25, 2017 114 (17) E3573-E3582; first published April 10, 2017. https://doi.org/10.1073/pnas.1615504114
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    Adaptation aftereffects reveal that tactile distance is a basic somatosensory feature

    Elena Calzolari, Elena Azañón, Matthew Danvers, Giuseppe Vallar, and Matthew R. Longo

    PNAS April 25, 2017 114 (17) 4555-4560; first published April 10, 2017. https://doi.org/10.1073/pnas.1614979114