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Edited by Richard G. Klein, Stanford University, Stanford, CA, and approved April 26, 2017 (received for review March 16, 2017)
Significance
The practice of weaning, the dietary transition from exclusive breastfeeding to exclusive nonmilk food, is a key aspect of development and evolution of hominins, but its study in the fossil record is hampered by a lack of unambiguous biomarkers. Ca stable isotope ratios of skeletal remains are expected to bear information about milk consumption. Here we demonstrate that modern human tooth enamel records a temporal variation of Ca isotope compositions, which is related to breastfeeding duration. Ca isotopes could be used as a biomarker for reconstruction of weaning practices in past human and fossil hominin species.
Abstract
Weaning practices differ among great apes and likely diverged during the course of human evolution, but behavioral inference from the fossil record is hampered by a lack of unambiguous biomarkers. Here, we show that early-life dietary transitions are recorded in human deciduous tooth enamel as marked variations in Ca isotope ratios (δ44/42Ca). Using a sequential microsampling method along the enamel growth axis, we collected more than 150 enamel microsamples from 51 deciduous teeth of 12 different modern human individuals of known dietary histories, as well as nine enamel samples from permanent third molars. We measured and reconstructed the evolution of 44Ca/42Ca ratios in enamel from in utero development to first months of postnatal development. We show that the observed variations of δ44/42Ca record a transition from placental nutrition to an adult-like diet and that Ca isotopes reflect the duration of the breastfeeding period experienced by each infant. Typically, the δ44/42Ca values of individuals briefly or not breastfed show a systematic increase during the first 5–10 mo, whereas individuals with long breastfeeding histories display no measurable variation in δ44/42Ca of enamel formed during this time. The use of Ca isotope analysis in tooth enamel allows microsampling and offers an independent approach to tackle challenging questions related to past population dynamics and evolution of weaning practices in hominins.
Footnotes
- ↵1To whom correspondence should be addressed. Email: theo.tacail{at}ens-lyon.fr.
Author contributions: J.E.M., C.C., L.V., and V.B. designed research; T.T. and B.T.-P. performed research; T.T. analyzed data; and T.T., B.T.-P., J.E.M., C.C., L.V., and V.B. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1704412114/-/DCSupplemental.
Assessing human weaning practices with Ca isotopes
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