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Table of Contents
August 08, 2017; vol. 114 no. 32
This Week in PNAS
Letters (Online Only)
- You have accessHelix instability and self-pairing prevent unnatural base pairs from expanding the genetic alphabetThomas P. HettingerPNAS August 8, 2017 114 (32) E6476-E6477; first published August 2, 2017. https://doi.org/10.1073/pnas.1703423114
- You have accessReply to Hettinger: Hydrophobic unnatural base pairs and the expansion of the genetic alphabetAaron W. Feldman, Michael P. Ledbetter, Yorke Zhang, and Floyd E. RomesbergPNAS August 8, 2017 114 (32) E6478-E6479; first published August 2, 2017. https://doi.org/10.1073/pnas.1708259114
See companion article:
- Engineered organism with expanded genetic alphabet- Jan 23, 2017
Inner Workings
An over-the-shoulder look at scientists at work.
- You have accessInner Workings: Climate change complicates fisheries modeling and management
- Front Matter
Gayathri Vaidyanathan
QnAs
- You have accessQnAs with Joe LutkenhausSandeep RavindranPNAS August 8, 2017 114 (32) 8438-8439; first published July 31, 2017. https://doi.org/10.1073/pnas.1711478114
See companion article:
- MinE conformational dynamics in Min oscillation- Jun 26, 2017
PNAS Plus Significance Statements
Brief statements written by the authors about the significance of their papers.
Physical Sciences
Applied Physical Sciences
- You have accessSpatial gene drives and pushed genetic wavesHidenori Tanaka, Howard A. Stone, and David R. NelsonPNAS August 8, 2017 114 (32) 8452-8457; first published July 25, 2017. https://doi.org/10.1073/pnas.1705868114
- You have accessOn the question of fractal packing structure in metallic glassesJun Ding, Mark Asta, and Robert O. RitchiePNAS August 8, 2017 114 (32) 8458-8463; first published July 25, 2017. https://doi.org/10.1073/pnas.1705723114
Biophysics and Computational Biology
- You have accessSolution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signalingMark M. Hughes, Peter Lavrencic, Rebecca C. Coll, Thomas Ve, Dylan G. Ryan, Niamh C. Williams, Deepthi Menon, Ashley Mansell, Philip G. Board, Mehdi Mobli, Bostjan Kobe, and Luke A. J. O’NeillPNAS August 8, 2017 114 (32) E6480-E6489; first published July 24, 2017. https://doi.org/10.1073/pnas.1701868114
- You have accessSerum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosisShobini Jayaraman, Donald L. Gantz, Christian Haupt, and Olga GurskyPNAS August 8, 2017 114 (32) E6507-E6515; first published July 25, 2017. https://doi.org/10.1073/pnas.1707120114
Chemistry
- You have accessDesign and synthesis of theranostic antibiotic nanodrugs that display enhanced antibacterial activity and luminescenceSheng Xie, Sesha Manuguri, Giampiero Proietti, Joakim Romson, Ying Fu, A. Ken Inge, Bin Wu, Yang Zhang, Daniel Häll, Olof Ramström, and Mingdi YanPNAS August 8, 2017 114 (32) 8464-8469; first published July 25, 2017. https://doi.org/10.1073/pnas.1708556114
Engineering
- You have accessLipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencingSamantha M. Sarett, Thomas A. Werfel, Linus Lee, Meredith A. Jackson, Kameron V. Kilchrist, Dana Brantley-Sieders, and Craig L. DuvallPNAS August 8, 2017 114 (32) E6490-E6497; first published July 24, 2017. https://doi.org/10.1073/pnas.1621240114
- Open AccessCavitation onset caused by accelerationZhao Pan, Akihito Kiyama, Yoshiyuki Tagawa, David J. Daily, Scott L. Thomson, Randy Hurd, and Tadd T. TruscottPNAS August 8, 2017 114 (32) 8470-8474; first published July 24, 2017. https://doi.org/10.1073/pnas.1702502114
- You have accessSynthetic quorum sensing in model microcapsule coloniesHenry Shum and Anna C. BalazsPNAS August 8, 2017 114 (32) 8475-8480; first published July 24, 2017. https://doi.org/10.1073/pnas.1702288114
Environmental Sciences
- You have accessRainforest-initiated wet season onset over the southern AmazonJonathon S. Wright, Rong Fu, John R. Worden, Sudip Chakraborty, Nicholas E. Clinton, Camille Risi, Ying Sun, and Lei YinPNAS August 8, 2017 114 (32) 8481-8486; first published July 20, 2017. https://doi.org/10.1073/pnas.1621516114
Physics
- You have accessRevised M06-L functional for improved accuracy on chemical reaction barrier heights, noncovalent interactions, and solid-state physicsYing Wang, Xinsheng Jin, Haoyu S. Yu, Donald G. Truhlar, and Xiao HePNAS August 8, 2017 114 (32) 8487-8492; first published July 24, 2017. https://doi.org/10.1073/pnas.1705670114
- Open AccessNature does not rely on long-lived electronic quantum coherence for photosynthetic energy transferHong-Guang Duan, Valentyn I. Prokhorenko, Richard J. Cogdell, Khuram Ashraf, Amy L. Stevens, Michael Thorwart, and R. J. Dwayne MillerPNAS August 8, 2017 114 (32) 8493-8498; first published July 25, 2017. https://doi.org/10.1073/pnas.1702261114
Statistics
- Open AccessLarge numbers of explanatory variables, a semi-descriptive analysisD. R. Cox and H. S. BatteyPNAS August 8, 2017 114 (32) 8592-8595; first published July 24, 2017. https://doi.org/10.1073/pnas.1703764114
Social Sciences
Anthropology
- You have accessGenomic landscape of human diversity across Madagascar
- From the Cover
Denis Pierron, Margit Heiske, Harilanto Razafindrazaka, Ignace Rakoto, Nelly Rabetokotany, Bodo Ravololomanga, Lucien M.-A. Rakotozafy, Mireille Mialy Rakotomalala, Michel Razafiarivony, Bako Rasoarifetra, Miakabola Andriamampianina Raharijesy, Lolona Razafindralambo, Ramilisonina, Fulgence Fanony, Sendra Lejamble, Olivier Thomas, Ahmed Mohamed Abdallah, Christophe Rocher, Amal Arachiche, Laure Tonaso, Veronica Pereda-loth, Stéphanie Schiavinato, Nicolas Brucato, Francois-Xavier Ricaut, Pradiptajati Kusuma, Herawati Sudoyo, Shengyu Ni, Anne Boland, Jean-Francois Deleuze, Philippe Beaujard, Philippe Grange, Sander Adelaar, Mark Stoneking, Jean-Aimé Rakotoarisoa, Chantal Radimilahy, and Thierry LetellierPNAS August 8, 2017 114 (32) E6498-E6506; first published July 17, 2017. https://doi.org/10.1073/pnas.1704906114
Psychological and Cognitive Sciences
- You have accessOptimal decision making and matching are tied through diminishing returnsJan KubanekPNAS August 8, 2017 114 (32) 8499-8504; first published July 24, 2017. https://doi.org/10.1073/pnas.1703440114
- You have accessExposure to and recall of violence reduce short-term memory and cognitive controlFrancesco Bogliacino, Gianluca Grimalda, Pietro Ortoleva, and Patrick RingPNAS August 8, 2017 114 (32) 8505-8510; first published July 24, 2017. https://doi.org/10.1073/pnas.1704651114
- You have accessDehumanization increases instrumental violence, but not moral violenceTage S. Rai, Piercarlo Valdesolo, and Jesse GrahamPNAS August 8, 2017 114 (32) 8511-8516; first published July 24, 2017. https://doi.org/10.1073/pnas.1705238114
See companion article:
- You have accessImplications of life-history strategies for obesityJon K. Maner, Andrea Dittmann, Andrea L. Meltzer, and James K. McNultyPNAS August 8, 2017 114 (32) 8517-8522; first published July 24, 2017. https://doi.org/10.1073/pnas.1620482114
Social Sciences
- Open AccessBuying time promotes happinessAshley V. Whillans, Elizabeth W. Dunn, Paul Smeets, Rene Bekkers, and Michael I. NortonPNAS August 8, 2017 114 (32) 8523-8527; first published July 24, 2017. https://doi.org/10.1073/pnas.1706541114
Sustainability Science
- You have accessAn invasive foundation species enhances multifunctionality in a coastal ecosystemAaron P. Ramus, Brian R. Silliman, Mads S. Thomsen, and Zachary T. LongPNAS August 8, 2017 114 (32) 8580-8585; first published July 17, 2017. https://doi.org/10.1073/pnas.1700353114
Biological Sciences
Anthropology
- You have accessGenomic landscape of human diversity across Madagascar
- From the Cover
Denis Pierron, Margit Heiske, Harilanto Razafindrazaka, Ignace Rakoto, Nelly Rabetokotany, Bodo Ravololomanga, Lucien M.-A. Rakotozafy, Mireille Mialy Rakotomalala, Michel Razafiarivony, Bako Rasoarifetra, Miakabola Andriamampianina Raharijesy, Lolona Razafindralambo, Ramilisonina, Fulgence Fanony, Sendra Lejamble, Olivier Thomas, Ahmed Mohamed Abdallah, Christophe Rocher, Amal Arachiche, Laure Tonaso, Veronica Pereda-loth, Stéphanie Schiavinato, Nicolas Brucato, Francois-Xavier Ricaut, Pradiptajati Kusuma, Herawati Sudoyo, Shengyu Ni, Anne Boland, Jean-Francois Deleuze, Philippe Beaujard, Philippe Grange, Sander Adelaar, Mark Stoneking, Jean-Aimé Rakotoarisoa, Chantal Radimilahy, and Thierry LetellierPNAS August 8, 2017 114 (32) E6498-E6506; first published July 17, 2017. https://doi.org/10.1073/pnas.1704906114
Applied Biological Sciences
- You have accessSalate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in miceYanping Wang, Steven J. Marling, Lori A. Plum, and Hector F. DeLucaPNAS August 8, 2017 114 (32) 8528-8531; first published July 24, 2017. https://doi.org/10.1073/pnas.1703995114
- You have accessConceptual framework of the eco-physiological phases of insect diapause development justified by transcriptomic profilingVladimír Koštál, Tomáš Štětina, Rodolphe Poupardin, Jaroslava Korbelová, and Alexander William BrucePNAS August 8, 2017 114 (32) 8532-8537; first published July 18, 2017. https://doi.org/10.1073/pnas.1707281114
Biochemistry
- You have accessSerum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosisShobini Jayaraman, Donald L. Gantz, Christian Haupt, and Olga GurskyPNAS August 8, 2017 114 (32) E6507-E6515; first published July 25, 2017. https://doi.org/10.1073/pnas.1707120114
- You have accessEffect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin IIXiong Liu, Neil Billington, Shi Shu, Shu-Hua Yu, Grzegorz Piszczek, James R. Sellers, and Edward D. KornPNAS August 8, 2017 114 (32) E6516-E6525; first published July 24, 2017. https://doi.org/10.1073/pnas.1702375114
- You have accessStructural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistanceRadoslaw Pluta, D. Roeland Boer, Fabián Lorenzo-Díaz, Silvia Russi, Hansel Gómez, Cris Fernández-López, Rosa Pérez-Luque, Modesto Orozco, Manuel Espinosa, and Miquel CollPNAS August 8, 2017 114 (32) E6526-E6535; first published July 24, 2017. https://doi.org/10.1073/pnas.1702971114
- You have accessUnique structural features of the AIPL1–FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindnessRavi P. Yadav, Lokesh Gakhar, Liping Yu, and Nikolai O. ArtemyevPNAS August 8, 2017 114 (32) E6536-E6545; first published July 24, 2017. https://doi.org/10.1073/pnas.1704782114
- You have accessA promiscuous split intein with expanded protein engineering applicationsAdam J. Stevens, Giridhar Sekar, Neel H. Shah, Anahita Z. Mostafavi, David Cowburn, and Tom W. MuirPNAS August 8, 2017 114 (32) 8538-8543; first published July 24, 2017. https://doi.org/10.1073/pnas.1701083114
- You have accessInterdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpointPietro Roversi, Lucia Marti, Alessandro T. Caputo, Dominic S. Alonzi, Johan C. Hill, Kyle C. Dent, Abhinav Kumar, Mikail D. Levasseur, Andrea Lia, Thomas Waksman, Souradeep Basu, Yentli Soto Albrecht, Kristin Qian, James Patrick McIvor, Colette B. Lipp, Dritan Siliqi, Snežana Vasiljević, Shabaz Mohammed, Petra Lukacik, Martin A. Walsh, Angelo Santino, and Nicole ZitzmannPNAS August 8, 2017 114 (32) 8544-8549; first published July 24, 2017. https://doi.org/10.1073/pnas.1703682114
- You have accessCrystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane associationWenting Zhang, Wenjie Zheng, Yukimatsu Toh, Miguel A. Betancourt-Solis, Jiagang Tu, Yanlin Fan, Vikram N. Vakharia, Jun Liu, James A. McNew, Meilin Jin, and Yizhi J. TaoPNAS August 8, 2017 114 (32) 8550-8555; first published July 24, 2017. https://doi.org/10.1073/pnas.1701747114
Biophysics and Computational Biology
- You have accessSpatial gene drives and pushed genetic wavesHidenori Tanaka, Howard A. Stone, and David R. NelsonPNAS August 8, 2017 114 (32) 8452-8457; first published July 25, 2017. https://doi.org/10.1073/pnas.1705868114
- You have accessEffective intermediate-spin iron in O2-transporting heme proteinsNils Schuth, Stefan Mebs, Dennis Huwald, Pierre Wrzolek, Matthias Schwalbe, Anja Hemschemeier, and Michael HaumannPNAS August 8, 2017 114 (32) 8556-8561; first published July 24, 2017. https://doi.org/10.1073/pnas.1706527114
- Open AccessMolecular mechanism of photoactivation of a light-regulated adenylate cyclaseMio Ohki, Ayana Sato-Tomita, Shigeru Matsunaga, Mineo Iseki, Jeremy R. H. Tame, Naoya Shibayama, and Sam-Yong ParkPNAS August 8, 2017 114 (32) 8562-8567; first published July 24, 2017. https://doi.org/10.1073/pnas.1704391114
Cell Biology
- You have accessProtein diversity in discrete structures at the distal tip of the trypanosome flagellumVladimir Varga, Flavia Moreira-Leite, Neil Portman, and Keith GullPNAS August 8, 2017 114 (32) E6546-E6555; first published July 19, 2017. https://doi.org/10.1073/pnas.1703553114
- You have accessCDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidationHeather J. Wright, Jue Hou, Binzhi Xu, Marvin Cortez, Eric O. Potma, Bruce J. Tromberg, and Olga V. RazorenovaPNAS August 8, 2017 114 (32) E6556-E6565; first published July 24, 2017. https://doi.org/10.1073/pnas.1703791114
- You have accessLipid rafts sense and direct electric field-induced migrationBo-jian Lin, Shun-hao Tsao, Alex Chen, Shu-Kai Hu, Ling Chao, and Pen-hsiu Grace ChaoPNAS August 8, 2017 114 (32) 8568-8573; first published July 24, 2017. https://doi.org/10.1073/pnas.1702526114
- You have accessUbiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagyYukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, and Keiji TanakaPNAS August 8, 2017 114 (32) 8574-8579; first published July 25, 2017. https://doi.org/10.1073/pnas.1702615114
Ecology
- You have accessAn invasive foundation species enhances multifunctionality in a coastal ecosystemAaron P. Ramus, Brian R. Silliman, Mads S. Thomsen, and Zachary T. LongPNAS August 8, 2017 114 (32) 8580-8585; first published July 17, 2017. https://doi.org/10.1073/pnas.1700353114
Evolution
- Open AccessEmbryo implantation evolved from an ancestral inflammatory attachment reactionOliver W. Griffith, Arun R. Chavan, Stella Protopapas, Jamie Maziarz, Roberto Romero, and Gunter P. WagnerPNAS August 8, 2017 114 (32) E6566-E6575; first published July 26, 2017. https://doi.org/10.1073/pnas.1701129114
See companion article:
- Inflammation before implantation- Dec 12, 2017
- You have accessFunctional characterization of odorant receptors in the ponerine ant, Harpegnathos saltator
- From the Cover
Jesse D. Slone, Gregory M. Pask, Stephen T. Ferguson, Jocelyn G. Millar, Shelley L. Berger, Danny Reinberg, Jürgen Liebig, Anandasankar Ray, and Laurence J. ZwiebelPNAS August 8, 2017 114 (32) 8586-8591; first published July 10, 2017. https://doi.org/10.1073/pnas.1704647114See companion article:
- Ant acute olfaction informs about social evolution- Aug 15, 2017
Genetics
- You have accessTwo functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans developmentKatja K. Dove, Hilary A. Kemp, Kristin R. Di Bona, Katherine H. Reiter, Luke J. Milburn, David Camacho, David S. Fay, Dana L. Miller, and Rachel E. KlevitPNAS August 8, 2017 114 (32) E6576-E6584; first published July 24, 2017. https://doi.org/10.1073/pnas.1705060114
- Open AccessLarge numbers of explanatory variables, a semi-descriptive analysisD. R. Cox and H. S. BatteyPNAS August 8, 2017 114 (32) 8592-8595; first published July 24, 2017. https://doi.org/10.1073/pnas.1703764114
- You have accessActivin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity modelWei Song, Edward Owusu-Ansah, Yanhui Hu, Daojun Cheng, Xiaochun Ni, Jonathan Zirin, and Norbert PerrimonPNAS August 8, 2017 114 (32) 8596-8601; first published July 24, 2017. https://doi.org/10.1073/pnas.1708037114
- You have accessDetection and quantification of inbreeding depression for complex traits from SNP dataLoic Yengo, Zhihong Zhu, Naomi R. Wray, Bruce S. Weir, Jian Yang, Matthew R. Robinson, and Peter M. VisscherPNAS August 8, 2017 114 (32) 8602-8607; first published July 26, 2017. https://doi.org/10.1073/pnas.1621096114
See companion article:
- You have accessDeacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell developmentKristy R. Stengel, Kelly R. Barnett, Jing Wang, Qi Liu, Emily Hodges, Scott W. Hiebert, and Srividya BhaskaraPNAS August 8, 2017 114 (32) 8608-8613; first published July 24, 2017. https://doi.org/10.1073/pnas.1701610114
Immunology and Inflammation
- You have accessSolution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signalingMark M. Hughes, Peter Lavrencic, Rebecca C. Coll, Thomas Ve, Dylan G. Ryan, Niamh C. Williams, Deepthi Menon, Ashley Mansell, Philip G. Board, Mehdi Mobli, Bostjan Kobe, and Luke A. J. O’NeillPNAS August 8, 2017 114 (32) E6480-E6489; first published July 24, 2017. https://doi.org/10.1073/pnas.1701868114
- Open AccessCortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytesAlex T. Ritter, Senta M. Kapnick, Sricharan Murugesan, Pamela L. Schwartzberg, Gillian M. Griffiths, and Jennifer Lippincott-SchwartzPNAS August 8, 2017 114 (32) E6585-E6594; first published July 17, 2017. https://doi.org/10.1073/pnas.1710751114
- You have accessSequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodiesJoyce K. Hwang, Chong Wang, Zhou Du, Robin M. Meyers, Thomas B. Kepler, Donna Neuberg, Peter D. Kwong, John R. Mascola, M. Gordon Joyce, Mattia Bonsignori, Barton F. Haynes, Leng-Siew Yeap, and Frederick W. AltPNAS August 8, 2017 114 (32) 8614-8619; first published July 26, 2017. https://doi.org/10.1073/pnas.1709203114
- You have accessNuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate responseJia Xu, Xiaoqing Xu, Bingjing Wang, Yuanwu Ma, Lianfeng Zhang, Henan Xu, Ye Hu, Jiacheng Wu, and Xuetao CaoPNAS August 8, 2017 114 (32) 8620-8625; first published July 24, 2017. https://doi.org/10.1073/pnas.1700917114
Medical Sciences
- You have accessProtein nanocages that penetrate airway mucus and tumor tissueXinglu Huang, Jane Chisholm, Jie Zhuang, Yanyu Xiao, Gregg Duncan, Xiaoyuan Chen, Jung Soo Suk, and Justin HanesPNAS August 8, 2017 114 (32) E6595-E6602; first published July 24, 2017. https://doi.org/10.1073/pnas.1705407114
- Open AccessRho-associated kinase is a therapeutic target in neuroblastomaCecilia Dyberg, Susanne Fransson, Teodora Andonova, Baldur Sveinbjörnsson, Jessika Lännerholm-Palm, Thale K. Olsen, David Forsberg, Eric Herlenius, Tommy Martinsson, Bertha Brodin, Per Kogner, John Inge Johnsen, and Malin WickströmPNAS August 8, 2017 114 (32) E6603-E6612; first published July 24, 2017. https://doi.org/10.1073/pnas.1706011114
- Open AccessMitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infectionNikolaos M. Nikolaidis, John G. Noel, Lori B. Pitstick, Jason C. Gardner, Yasuaki Uehara, Huixing Wu, Atsushi Saito, Kara E. Lewnard, Huan Liu, Mitchell R. White, Kevan L. Hartshorn, and Francis X. McCormackPNAS August 8, 2017 114 (32) E6613-E6622; first published July 24, 2017. https://doi.org/10.1073/pnas.1621172114
- You have accessTherapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastomaNan Li, Haiying Fu, Stephen M. Hewitt, Dimiter S. Dimitrov, and Mitchell HoPNAS August 8, 2017 114 (32) E6623-E6631; first published July 24, 2017. https://doi.org/10.1073/pnas.1706055114
Microbiology
- Open AccessNontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery
- From the Cover
Joseph A. Jurcisek, Kenneth L. Brockman, Laura A. Novotny, Steven D. Goodman, and Lauren O. BakaletzPNAS August 8, 2017 114 (32) E6632-E6641; first published July 10, 2017. https://doi.org/10.1073/pnas.1705508114See companion article:
- Haemophilus spills its guts to make a biofilm- Jul 26, 2017
- You have accessHEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumorsOdile Heidmann, Anthony Béguin, Janio Paternina, Raphaël Berthier, Marc Deloger, Olivia Bawa, and Thierry HeidmannPNAS August 8, 2017 114 (32) E6642-E6651; first published July 24, 2017. https://doi.org/10.1073/pnas.1702204114
- Open AccessAntibacterial photosensitization through activation of coproporphyrinogen oxidaseMatthew C. Surdel, Dennis J. Horvath Jr., Lisa J. Lojek, Audra R. Fullen, Jocelyn Simpson, Brendan F. Dutter, Kenneth J. Salleng, Jeremy B. Ford, J. Logan Jenkins, Raju Nagarajan, Pedro L. Teixeira, Matthew Albertolle, Ivelin S. Georgiev, E. Duco Jansen, Gary A. Sulikowski, D. Borden Lacy, Harry A. Dailey, and Eric P. SkaarPNAS August 8, 2017 114 (32) E6652-E6659; first published July 24, 2017. https://doi.org/10.1073/pnas.1700469114
Neuroscience
- Open AccessThalamocortical synchronization during induction and emergence from propofol-induced unconsciousnessFrancisco J. Flores, Katharine E. Hartnack, Amanda B. Fath, Seong-Eun Kim, Matthew A. Wilson, Emery N. Brown, and Patrick L. PurdonPNAS August 8, 2017 114 (32) E6660-E6668; first published July 25, 2017. https://doi.org/10.1073/pnas.1700148114
- You have accessSIK3–HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neuronsShinsuke Fujii, Patrick Emery, and Hubert AmreinPNAS August 8, 2017 114 (32) E6669-E6677; first published July 25, 2017. https://doi.org/10.1073/pnas.1620483114
- Open AccessStructural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neuronsBoran Han, Ruobo Zhou, Chenglong Xia, and Xiaowei ZhuangPNAS August 8, 2017 114 (32) E6678-E6685; first published July 24, 2017. https://doi.org/10.1073/pnas.1705043114
- You have accessMedial temporal lobe and topographical memoryZhisen J. Urgolites, Ramona O. Hopkins, and Larry R. SquirePNAS August 8, 2017 114 (32) 8626-8630; first published July 24, 2017. https://doi.org/10.1073/pnas.1708963114
- You have accessBACE inhibition-dependent repair of Alzheimer’s pathophysiology
- From the Cover
Aylin D. Keskin, Maja Kekuš, Helmuth Adelsberger, Ulf Neumann, Derya R. Shimshek, Beomjong Song, Benedikt Zott, Tingying Peng, Hans Förstl, Matthias Staufenbiel, Israel Nelken, Bert Sakmann, Arthur Konnerth, and Marc Aurel BuschePNAS August 8, 2017 114 (32) 8631-8636; first published July 24, 2017. https://doi.org/10.1073/pnas.1708106114 - You have accessInteractions between feedback and lateral connections in the primary visual cortexHualou Liang, Xiajing Gong, Minggui Chen, Yin Yan, Wu Li, and Charles D. GilbertPNAS August 8, 2017 114 (32) 8637-8642; first published July 24, 2017. https://doi.org/10.1073/pnas.1706183114
- You have accessNeural basis for hand muscle synergies in the primate spinal cordTomohiko Takei, Joachim Confais, Saeka Tomatsu, Tomomichi Oya, and Kazuhiko SekiPNAS August 8, 2017 114 (32) 8643-8648; first published July 24, 2017. https://doi.org/10.1073/pnas.1704328114
Pharmacology
- You have accessLipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencingSamantha M. Sarett, Thomas A. Werfel, Linus Lee, Meredith A. Jackson, Kameron V. Kilchrist, Dana Brantley-Sieders, and Craig L. DuvallPNAS August 8, 2017 114 (32) E6490-E6497; first published July 24, 2017. https://doi.org/10.1073/pnas.1621240114
Physiology
- Open AccessSUMOylation determines the voltage required to activate cardiac IKs channelsDazhi Xiong, Tian Li, Hui Dai, Anthony F. Arena, Leigh D. Plant, and Steve A. N. GoldsteinPNAS August 8, 2017 114 (32) E6686-E6694; first published July 25, 2017. https://doi.org/10.1073/pnas.1706267114
- Open AccessMapping of human brown adipose tissue in lean and obese young menBrooks P. Leitner, Shan Huang, Robert J. Brychta, Courtney J. Duckworth, Alison S. Baskin, Suzanne McGehee, Ilan Tal, William Dieckmann, Garima Gupta, Gerald M. Kolodny, Karel Pacak, Peter Herscovitch, Aaron M. Cypess, and Kong Y. ChenPNAS August 8, 2017 114 (32) 8649-8654; first published July 24, 2017. https://doi.org/10.1073/pnas.1705287114
Plant Biology
- You have accessPIF3 is a negative regulator of the CBF pathway and freezing tolerance in ArabidopsisBochen Jiang, Yiting Shi, Xiaoyan Zhang, Xiaoyun Xin, Lijuan Qi, Hongwei Guo, Jigang Li, and Shuhua YangPNAS August 8, 2017 114 (32) E6695-E6702; first published July 24, 2017. https://doi.org/10.1073/pnas.1706226114
- Open AccessStem parasitic plant Cuscuta australis (dodder) transfers herbivory-induced signals among plants
- From the Cover
Christian Hettenhausen, Juan Li, Huifu Zhuang, Huanhuan Sun, Yuxing Xu, Jinfeng Qi, Jingxiong Zhang, Yunting Lei, Yan Qin, Guiling Sun, Lei Wang, Ian T. Baldwin, and Jianqiang WuPNAS August 8, 2017 114 (32) E6703-E6709; first published July 24, 2017. https://doi.org/10.1073/pnas.1704536114 - You have accessLEC1 sequentially regulates the transcription of genes involved in diverse developmental processes during seed developmentJulie M. Pelletier, Raymond W. Kwong, Soomin Park, Brandon H. Le, Russell Baden, Alexandro Cagliari, Meryl Hashimoto, Matthew D. Munoz, Robert L. Fischer, Robert B. Goldberg, and John J. HaradaPNAS August 8, 2017 114 (32) E6710-E6719; first published July 24, 2017. https://doi.org/10.1073/pnas.1707957114
Psychological and Cognitive Sciences
- Open AccessThe critical phase for visual control of human walking over complex terrainJonathan Samir Matthis, Sean L. Barton, and Brett R. FajenPNAS August 8, 2017 114 (32) E6720-E6729; first published July 24, 2017. https://doi.org/10.1073/pnas.1611699114
- You have accessOptimal decision making and matching are tied through diminishing returnsJan KubanekPNAS August 8, 2017 114 (32) 8499-8504; first published July 24, 2017. https://doi.org/10.1073/pnas.1703440114
Sustainability Science
- You have accessRainforest metropolis casts 1,000-km defaunation shadowDaniel J. Tregidgo, Jos Barlow, Paulo S. Pompeu, Mayana de Almeida Rocha, and Luke ParryPNAS August 8, 2017 114 (32) 8655-8659; first published July 24, 2017. https://doi.org/10.1073/pnas.1614499114
Corrections (Online Only)
- You have accessCorrection for Barry et al., Optical magnetic detection of single-neuron action potentials using quantum defects in diamondPNAS August 8, 2017 114 (32) E6730; first published August 8, 2017. https://doi.org/10.1073/pnas.1712523114
- You have accessCorrection for Wu et al., Fibroblast growth factor signaling instructs ensheathing glia wrapping of Drosophila olfactory glomeruliPNAS August 8, 2017 114 (32) E6731; first published August 8, 2017. https://doi.org/10.1073/pnas.1712520114
- You have accessCorrection for Breuer et al., System-wide organization of actin cytoskeleton determines organelle transport in hypocotyl plant cellsPNAS August 8, 2017 114 (32) E6732; first published July 31, 2017. https://doi.org/10.1073/pnas.1712371114
Commentaries
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