Table of Contents

Biological Sciences

• Anthropology

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    Genomic landscape of human diversity across Madagascar

    • From the Cover

    Denis Pierron, Margit Heiske, Harilanto Razafindrazaka, Ignace Rakoto, Nelly Rabetokotany, Bodo Ravololomanga, Lucien M.-A. Rakotozafy, Mireille Mialy Rakotomalala, Michel Razafiarivony, Bako Rasoarifetra, Miakabola Andriamampianina Raharijesy, Lolona Razafindralambo, Ramilisonina, Fulgence Fanony, Sendra Lejamble, Olivier Thomas, Ahmed Mohamed Abdallah, Christophe Rocher, Amal Arachiche, Laure Tonaso, Veronica Pereda-loth, Stéphanie Schiavinato, Nicolas Brucato, Francois-Xavier Ricaut, Pradiptajati Kusuma, Herawati Sudoyo, Shengyu Ni, Anne Boland, Jean-Francois Deleuze, Philippe Beaujard, Philippe Grange, Sander Adelaar, Mark Stoneking, Jean-Aimé Rakotoarisoa, Chantal Radimilahy, and Thierry Letellier

    PNAS August 8, 2017 114 (32) E6498-E6506; first published July 17, 2017. https://doi.org/10.1073/pnas.1704906114

• Applied Biological Sciences

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    Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice

    Yanping Wang, Steven J. Marling, Lori A. Plum, and Hector F. DeLuca

    PNAS August 8, 2017 114 (32) 8528-8531; first published July 24, 2017. https://doi.org/10.1073/pnas.1703995114
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    Conceptual framework of the eco-physiological phases of insect diapause development justified by transcriptomic profiling

    Vladimír Koštál, Tomáš Štětina, Rodolphe Poupardin, Jaroslava Korbelová, and Alexander William Bruce

    PNAS August 8, 2017 114 (32) 8532-8537; first published July 18, 2017. https://doi.org/10.1073/pnas.1707281114

• Biochemistry

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    Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis

    Shobini Jayaraman, Donald L. Gantz, Christian Haupt, and Olga Gursky

    PNAS August 8, 2017 114 (32) E6507-E6515; first published July 25, 2017. https://doi.org/10.1073/pnas.1707120114
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    Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II

    Xiong Liu, Neil Billington, Shi Shu, Shu-Hua Yu, Grzegorz Piszczek, James R. Sellers, and Edward D. Korn

    PNAS August 8, 2017 114 (32) E6516-E6525; first published July 24, 2017. https://doi.org/10.1073/pnas.1702375114
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    Structural basis of a histidine-DNA nicking/joining mechanism for gene transfer and promiscuous spread of antibiotic resistance

    Radoslaw Pluta, D. Roeland Boer, Fabián Lorenzo-Díaz, Silvia Russi, Hansel Gómez, Cris Fernández-López, Rosa Pérez-Luque, Modesto Orozco, Manuel Espinosa, and Miquel Coll

    PNAS August 8, 2017 114 (32) E6526-E6535; first published July 24, 2017. https://doi.org/10.1073/pnas.1702971114
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    Unique structural features of the AIPL1–FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness

    Ravi P. Yadav, Lokesh Gakhar, Liping Yu, and Nikolai O. Artemyev

    PNAS August 8, 2017 114 (32) E6536-E6545; first published July 24, 2017. https://doi.org/10.1073/pnas.1704782114
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    A promiscuous split intein with expanded protein engineering applications

    Adam J. Stevens, Giridhar Sekar, Neel H. Shah, Anahita Z. Mostafavi, David Cowburn, and Tom W. Muir

    PNAS August 8, 2017 114 (32) 8538-8543; first published July 24, 2017. https://doi.org/10.1073/pnas.1701083114
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    Interdomain conformational flexibility underpins the activity of UGGT, the eukaryotic glycoprotein secretion checkpoint

    Pietro Roversi, Lucia Marti, Alessandro T. Caputo, Dominic S. Alonzi, Johan C. Hill, Kyle C. Dent, Abhinav Kumar, Mikail D. Levasseur, Andrea Lia, Thomas Waksman, Souradeep Basu, Yentli Soto Albrecht, Kristin Qian, James Patrick McIvor, Colette B. Lipp, Dritan Siliqi, Snežana Vasiljević, Shabaz Mohammed, Petra Lukacik, Martin A. Walsh, Angelo Santino, and Nicole Zitzmann

    PNAS August 8, 2017 114 (32) 8544-8549; first published July 24, 2017. https://doi.org/10.1073/pnas.1703682114
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    Crystal structure of an orthomyxovirus matrix protein reveals mechanisms for self-polymerization and membrane association

    Wenting Zhang, Wenjie Zheng, Yukimatsu Toh, Miguel A. Betancourt-Solis, Jiagang Tu, Yanlin Fan, Vikram N. Vakharia, Jun Liu, James A. McNew, Meilin Jin, and Yizhi J. Tao

    PNAS August 8, 2017 114 (32) 8550-8555; first published July 24, 2017. https://doi.org/10.1073/pnas.1701747114

• Biophysics and Computational Biology

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    Spatial gene drives and pushed genetic waves

    Hidenori Tanaka, Howard A. Stone, and David R. Nelson

    PNAS August 8, 2017 114 (32) 8452-8457; first published July 25, 2017. https://doi.org/10.1073/pnas.1705868114
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    Effective intermediate-spin iron in O₂-transporting heme proteins

    Nils Schuth, Stefan Mebs, Dennis Huwald, Pierre Wrzolek, Matthias Schwalbe, Anja Hemschemeier, and Michael Haumann

    PNAS August 8, 2017 114 (32) 8556-8561; first published July 24, 2017. https://doi.org/10.1073/pnas.1706527114
  • Open Access

    Molecular mechanism of photoactivation of a light-regulated adenylate cyclase

    Mio Ohki, Ayana Sato-Tomita, Shigeru Matsunaga, Mineo Iseki, Jeremy R. H. Tame, Naoya Shibayama, and Sam-Yong Park

    PNAS August 8, 2017 114 (32) 8562-8567; first published July 24, 2017. https://doi.org/10.1073/pnas.1704391114

• Cell Biology

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    Protein diversity in discrete structures at the distal tip of the trypanosome flagellum

    Vladimir Varga, Flavia Moreira-Leite, Neil Portman, and Keith Gull

    PNAS August 8, 2017 114 (32) E6546-E6555; first published July 19, 2017. https://doi.org/10.1073/pnas.1703553114
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    CDCP1 drives triple-negative breast cancer metastasis through reduction of lipid-droplet abundance and stimulation of fatty acid oxidation

    Heather J. Wright, Jue Hou, Binzhi Xu, Marvin Cortez, Eric O. Potma, Bruce J. Tromberg, and Olga V. Razorenova

    PNAS August 8, 2017 114 (32) E6556-E6565; first published July 24, 2017. https://doi.org/10.1073/pnas.1703791114
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    Lipid rafts sense and direct electric field-induced migration

    Bo-jian Lin, Shun-hao Tsao, Alex Chen, Shu-Kai Hu, Ling Chao, and Pen-hsiu Grace Chao

    PNAS August 8, 2017 114 (32) 8568-8573; first published July 24, 2017. https://doi.org/10.1073/pnas.1702526114
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    Ubiquitination of exposed glycoproteins by SCF^FBXO27 directs damaged lysosomes for autophagy

    Yukiko Yoshida, Sayaka Yasuda, Toshiharu Fujita, Maho Hamasaki, Arisa Murakami, Junko Kawawaki, Kazuhiro Iwai, Yasushi Saeki, Tamotsu Yoshimori, Noriyuki Matsuda, and Keiji Tanaka

    PNAS August 8, 2017 114 (32) 8574-8579; first published July 25, 2017. https://doi.org/10.1073/pnas.1702615114

• Ecology

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    An invasive foundation species enhances multifunctionality in a coastal ecosystem

    Aaron P. Ramus, Brian R. Silliman, Mads S. Thomsen, and Zachary T. Long

    PNAS August 8, 2017 114 (32) 8580-8585; first published July 17, 2017. https://doi.org/10.1073/pnas.1700353114

• Evolution

  • Open Access

    Embryo implantation evolved from an ancestral inflammatory attachment reaction

    Oliver W. Griffith, Arun R. Chavan, Stella Protopapas, Jamie Maziarz, Roberto Romero, and Gunter P. Wagner

    PNAS August 8, 2017 114 (32) E6566-E6575; first published July 26, 2017. https://doi.org/10.1073/pnas.1701129114

    See companion article:

    • Reply to Liu: Inflammation before implantation both in evolution and development

      - Jan 02, 2018
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    Functional characterization of odorant receptors in the ponerine ant, Harpegnathos saltator

    • From the Cover

    Jesse D. Slone, Gregory M. Pask, Stephen T. Ferguson, Jocelyn G. Millar, Shelley L. Berger, Danny Reinberg, Jürgen Liebig, Anandasankar Ray, and Laurence J. Zwiebel

    PNAS August 8, 2017 114 (32) 8586-8591; first published July 10, 2017. https://doi.org/10.1073/pnas.1704647114

    See companion article:

    • Decoding ants’ olfactory system sheds light on the evolution of social communication

      - Aug 22, 2017

• Genetics

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    Two functionally distinct E2/E3 pairs coordinate sequential ubiquitination of a common substrate in Caenorhabditis elegans development

    Katja K. Dove, Hilary A. Kemp, Kristin R. Di Bona, Katherine H. Reiter, Luke J. Milburn, David Camacho, David S. Fay, Dana L. Miller, and Rachel E. Klevit

    PNAS August 8, 2017 114 (32) E6576-E6584; first published July 24, 2017. https://doi.org/10.1073/pnas.1705060114
  • Open Access

    Large numbers of explanatory variables, a semi-descriptive analysis

    D. R. Cox and H. S. Battey

    PNAS August 8, 2017 114 (32) 8592-8595; first published July 24, 2017. https://doi.org/10.1073/pnas.1703764114
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    Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model

    Wei Song, Edward Owusu-Ansah, Yanhui Hu, Daojun Cheng, Xiaochun Ni, Jonathan Zirin, and Norbert Perrimon

    PNAS August 8, 2017 114 (32) 8596-8601; first published July 24, 2017. https://doi.org/10.1073/pnas.1708037114
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    Detection and quantification of inbreeding depression for complex traits from SNP data

    Loic Yengo, Zhihong Zhu, Naomi R. Wray, Bruce S. Weir, Jian Yang, Matthew R. Robinson, and Peter M. Visscher

    PNAS August 8, 2017 114 (32) 8602-8607; first published July 26, 2017. https://doi.org/10.1073/pnas.1621096114

    See companion article:

    • Reply to Kardos et al.: Estimation of inbreeding depression from SNP data

      - Mar 13, 2018
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    Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development

    Kristy R. Stengel, Kelly R. Barnett, Jing Wang, Qi Liu, Emily Hodges, Scott W. Hiebert, and Srividya Bhaskara

    PNAS August 8, 2017 114 (32) 8608-8613; first published July 24, 2017. https://doi.org/10.1073/pnas.1701610114

• Immunology and Inflammation

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    Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

    Mark M. Hughes, Peter Lavrencic, Rebecca C. Coll, Thomas Ve, Dylan G. Ryan, Niamh C. Williams, Deepthi Menon, Ashley Mansell, Philip G. Board, Mehdi Mobli, Bostjan Kobe, and Luke A. J. O’Neill

    PNAS August 8, 2017 114 (32) E6480-E6489; first published July 24, 2017. https://doi.org/10.1073/pnas.1701868114
  • Open Access

    Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes

    Alex T. Ritter, Senta M. Kapnick, Sricharan Murugesan, Pamela L. Schwartzberg, Gillian M. Griffiths, and Jennifer Lippincott-Schwartz

    PNAS August 8, 2017 114 (32) E6585-E6594; first published July 17, 2017. https://doi.org/10.1073/pnas.1710751114
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    Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

    Joyce K. Hwang, Chong Wang, Zhou Du, Robin M. Meyers, Thomas B. Kepler, Donna Neuberg, Peter D. Kwong, John R. Mascola, M. Gordon Joyce, Mattia Bonsignori, Barton F. Haynes, Leng-Siew Yeap, and Frederick W. Alt

    PNAS August 8, 2017 114 (32) 8614-8619; first published July 26, 2017. https://doi.org/10.1073/pnas.1709203114
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    Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response

    Jia Xu, Xiaoqing Xu, Bingjing Wang, Yuanwu Ma, Lianfeng Zhang, Henan Xu, Ye Hu, Jiacheng Wu, and Xuetao Cao

    PNAS August 8, 2017 114 (32) 8620-8625; first published July 24, 2017. https://doi.org/10.1073/pnas.1700917114

• Medical Sciences

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    Protein nanocages that penetrate airway mucus and tumor tissue

    Xinglu Huang, Jane Chisholm, Jie Zhuang, Yanyu Xiao, Gregg Duncan, Xiaoyuan Chen, Jung Soo Suk, and Justin Hanes

    PNAS August 8, 2017 114 (32) E6595-E6602; first published July 24, 2017. https://doi.org/10.1073/pnas.1705407114
  • Open Access

    Rho-associated kinase is a therapeutic target in neuroblastoma

    Cecilia Dyberg, Susanne Fransson, Teodora Andonova, Baldur Sveinbjörnsson, Jessika Lännerholm-Palm, Thale K. Olsen, David Forsberg, Eric Herlenius, Tommy Martinsson, Bertha Brodin, Per Kogner, John Inge Johnsen, and Malin Wickström

    PNAS August 8, 2017 114 (32) E6603-E6612; first published July 24, 2017. https://doi.org/10.1073/pnas.1706011114
  • Open Access

    Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection

    Nikolaos M. Nikolaidis, John G. Noel, Lori B. Pitstick, Jason C. Gardner, Yasuaki Uehara, Huixing Wu, Atsushi Saito, Kara E. Lewnard, Huan Liu, Mitchell R. White, Kevan L. Hartshorn, and Francis X. McCormack

    PNAS August 8, 2017 114 (32) E6613-E6622; first published July 24, 2017. https://doi.org/10.1073/pnas.1621172114
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    Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma

    Nan Li, Haiying Fu, Stephen M. Hewitt, Dimiter S. Dimitrov, and Mitchell Ho

    PNAS August 8, 2017 114 (32) E6623-E6631; first published July 24, 2017. https://doi.org/10.1073/pnas.1706055114

• Microbiology

  • Open Access

    Nontypeable Haemophilus influenzae releases DNA and DNABII proteins via a T4SS-like complex and ComE of the type IV pilus machinery

    • From the Cover

    Joseph A. Jurcisek, Kenneth L. Brockman, Laura A. Novotny, Steven D. Goodman, and Lauren O. Bakaletz

    PNAS August 8, 2017 114 (32) E6632-E6641; first published July 10, 2017. https://doi.org/10.1073/pnas.1705508114

    See companion article:

    • Haemophilus spills its guts to make a biofilm

      - Aug 08, 2017
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    HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumors

    Odile Heidmann, Anthony Béguin, Janio Paternina, Raphaël Berthier, Marc Deloger, Olivia Bawa, and Thierry Heidmann

    PNAS August 8, 2017 114 (32) E6642-E6651; first published July 24, 2017. https://doi.org/10.1073/pnas.1702204114
  • Open Access

    Antibacterial photosensitization through activation of coproporphyrinogen oxidase

    Matthew C. Surdel, Dennis J. Horvath Jr., Lisa J. Lojek, Audra R. Fullen, Jocelyn Simpson, Brendan F. Dutter, Kenneth J. Salleng, Jeremy B. Ford, J. Logan Jenkins, Raju Nagarajan, Pedro L. Teixeira, Matthew Albertolle, Ivelin S. Georgiev, E. Duco Jansen, Gary A. Sulikowski, D. Borden Lacy, Harry A. Dailey, and Eric P. Skaar

    PNAS August 8, 2017 114 (32) E6652-E6659; first published July 24, 2017. https://doi.org/10.1073/pnas.1700469114

• Neuroscience

  • Open Access

    Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness

    Francisco J. Flores, Katharine E. Hartnack, Amanda B. Fath, Seong-Eun Kim, Matthew A. Wilson, Emery N. Brown, and Patrick L. Purdon

    PNAS August 8, 2017 114 (32) E6660-E6668; first published July 25, 2017. https://doi.org/10.1073/pnas.1700148114
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    SIK3–HDAC4 signaling regulates Drosophila circadian male sex drive rhythm via modulating the DN1 clock neurons

    Shinsuke Fujii, Patrick Emery, and Hubert Amrein

    PNAS August 8, 2017 114 (32) E6669-E6677; first published July 25, 2017. https://doi.org/10.1073/pnas.1620483114
  • Open Access

    Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

    Boran Han, Ruobo Zhou, Chenglong Xia, and Xiaowei Zhuang

    PNAS August 8, 2017 114 (32) E6678-E6685; first published July 24, 2017. https://doi.org/10.1073/pnas.1705043114
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    Medial temporal lobe and topographical memory

    Zhisen J. Urgolites, Ramona O. Hopkins, and Larry R. Squire

    PNAS August 8, 2017 114 (32) 8626-8630; first published July 24, 2017. https://doi.org/10.1073/pnas.1708963114
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    BACE inhibition-dependent repair of Alzheimer’s pathophysiology

    • From the Cover

    Aylin D. Keskin, Maja Kekuš, Helmuth Adelsberger, Ulf Neumann, Derya R. Shimshek, Beomjong Song, Benedikt Zott, Tingying Peng, Hans Förstl, Matthias Staufenbiel, Israel Nelken, Bert Sakmann, Arthur Konnerth, and Marc Aurel Busche

    PNAS August 8, 2017 114 (32) 8631-8636; first published July 24, 2017. https://doi.org/10.1073/pnas.1708106114
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    Interactions between feedback and lateral connections in the primary visual cortex

    Hualou Liang, Xiajing Gong, Minggui Chen, Yin Yan, Wu Li, and Charles D. Gilbert

    PNAS August 8, 2017 114 (32) 8637-8642; first published July 24, 2017. https://doi.org/10.1073/pnas.1706183114
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    Neural basis for hand muscle synergies in the primate spinal cord

    Tomohiko Takei, Joachim Confais, Saeka Tomatsu, Tomomichi Oya, and Kazuhiko Seki

    PNAS August 8, 2017 114 (32) 8643-8648; first published July 24, 2017. https://doi.org/10.1073/pnas.1704328114

• Pharmacology

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    Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

    Samantha M. Sarett, Thomas A. Werfel, Linus Lee, Meredith A. Jackson, Kameron V. Kilchrist, Dana Brantley-Sieders, and Craig L. Duvall

    PNAS August 8, 2017 114 (32) E6490-E6497; first published July 24, 2017. https://doi.org/10.1073/pnas.1621240114

• Physiology

  • Open Access

    SUMOylation determines the voltage required to activate cardiac I_Ks channels

    Dazhi Xiong, Tian Li, Hui Dai, Anthony F. Arena, Leigh D. Plant, and Steve A. N. Goldstein

    PNAS August 8, 2017 114 (32) E6686-E6694; first published July 25, 2017. https://doi.org/10.1073/pnas.1706267114
  • Open Access

    Mapping of human brown adipose tissue in lean and obese young men

    Brooks P. Leitner, Shan Huang, Robert J. Brychta, Courtney J. Duckworth, Alison S. Baskin, Suzanne McGehee, Ilan Tal, William Dieckmann, Garima Gupta, Gerald M. Kolodny, Karel Pacak, Peter Herscovitch, Aaron M. Cypess, and Kong Y. Chen

    PNAS August 8, 2017 114 (32) 8649-8654; first published July 24, 2017. https://doi.org/10.1073/pnas.1705287114

• Plant Biology

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    PIF3 is a negative regulator of the CBF pathway and freezing tolerance in Arabidopsis

    Bochen Jiang, Yiting Shi, Xiaoyan Zhang, Xiaoyun Xin, Lijuan Qi, Hongwei Guo, Jigang Li, and Shuhua Yang

    PNAS August 8, 2017 114 (32) E6695-E6702; first published July 24, 2017. https://doi.org/10.1073/pnas.1706226114
  • Open Access

    Stem parasitic plant Cuscuta australis (dodder) transfers herbivory-induced signals among plants

    • From the Cover

    Christian Hettenhausen, Juan Li, Huifu Zhuang, Huanhuan Sun, Yuxing Xu, Jinfeng Qi, Jingxiong Zhang, Yunting Lei, Yan Qin, Guiling Sun, Lei Wang, Ian T. Baldwin, and Jianqiang Wu

    PNAS August 8, 2017 114 (32) E6703-E6709; first published July 24, 2017. https://doi.org/10.1073/pnas.1704536114
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    LEC1 sequentially regulates the transcription of genes involved in diverse developmental processes during seed development

    Julie M. Pelletier, Raymond W. Kwong, Soomin Park, Brandon H. Le, Russell Baden, Alexandro Cagliari, Meryl Hashimoto, Matthew D. Munoz, Robert L. Fischer, Robert B. Goldberg, and John J. Harada

    PNAS August 8, 2017 114 (32) E6710-E6719; first published July 24, 2017. https://doi.org/10.1073/pnas.1707957114

• Psychological and Cognitive Sciences

  • Open Access

    The critical phase for visual control of human walking over complex terrain

    Jonathan Samir Matthis, Sean L. Barton, and Brett R. Fajen

    PNAS August 8, 2017 114 (32) E6720-E6729; first published July 24, 2017. https://doi.org/10.1073/pnas.1611699114
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    Optimal decision making and matching are tied through diminishing returns

    Jan Kubanek

    PNAS August 8, 2017 114 (32) 8499-8504; first published July 24, 2017. https://doi.org/10.1073/pnas.1703440114

• Sustainability Science

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    Rainforest metropolis casts 1,000-km defaunation shadow

    Daniel J. Tregidgo, Jos Barlow, Paulo S. Pompeu, Mayana de Almeida Rocha, and Luke Parry

    PNAS August 8, 2017 114 (32) 8655-8659; first published July 24, 2017. https://doi.org/10.1073/pnas.1614499114