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Identification of individuals by trait prediction using whole-genome sequencing data
Contributed by J. Craig Venter, June 28, 2017 (sent for review February 7, 2017; reviewed by Jean-Pierre Hubaux, Bradley Adam Malin, and Effy Vayena)
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Online Impact
Article Information
- Published in issue September 19, 2017.
- Published first September 5, 2017.
Author Information
- Christoph Lipperta,1,
- Riccardo Sabatinia,
- M. Cyrus Mahera,
- Eun Yong Kanga,
- Seunghak Leea,
- Okan Arikana,
- Alena Harleya,
- Axel Bernala,
- Peter Garsta,
- Victor Lavrenkoa,
- Ken Yocuma,
- Theodore Wonga,
- Mingfu Zhua,
- Wen-Yun Yanga,
- Chris Changa,
- Tim Lub,
- Charlie W. H. Leeb,
- Barry Hicksa,
- Smriti Ramakrishnana,
- Haibao Tanga,
- Chao Xiec,
- Jason Piperc,
- Suzanne Brewertonc,
- Yaron Turpazb,c,
- Amalio Telentib,
- Rhonda K. Robyb,d,2,
- Franz J. Ocha, and
- J. Craig Venterb,d,1
- aHuman Longevity, Inc., Mountain View, CA 94303;
- bHuman Longevity, Inc., San Diego, CA 92121;
- cHuman Longevity Singapore, Pte. Ltd., Singapore 138542;
- dJ. Craig Venter Institute, La Jolla, CA 92037
Contributed by J. Craig Venter, June 28, 2017 (sent for review February 7, 2017; reviewed by Jean-Pierre Hubaux, Bradley Adam Malin, and Effy Vayena)
Footnotes
- ↵1To whom correspondence may be addressed. Email: jcventer{at}jcvi.org or clippert{at}humanlongevity.com.
↵2Present address: Forensic Biology Unit, Alameda County Sheriff's Office, Oakland, CA 94605.
Author contributions: C.L., M.C.M., F.J.O., and J.C.V. designed research; C.L., M.C.M., V.L., and F.J.O. devised the method for reidentification; C.L., M.C.M., and C.X. performed research; C.L., R.S., M.C.M., E.Y.K., O.A., A.H., A.B., P.G., V.L., K.Y., T.W., M.Z., W.-Y.Y., C.C., T.L., C.W.H.L., B.H., C.X., J.P., S.B., and Y.T. contributed new reagents/analytic tools; C.L., R.S., M.C.M., E.Y.K., O.A., A.H., A.B., P.G., K.Y., T.W., M.Z., W.-Y.Y., T.L., C.W.H.L., and J.P. contributed phenotype prediction models; C.L., R.S., M.C.M., E.Y.K., S.L., O.A., A.H., A.B., P.G., V.L., K.Y., T.W., C.C., S.R., H.T., C.X., R.K.R., and F.J.O. analyzed data; C.L., F.J.O., and J.C.V. supervised the data analysis; A.T., R.K.R., and J.C.V. supervised the study cohort; C.L., M.C.M., A.T., and R.K.R. wrote the paper; and C.L., M.C.M., E.Y.K., S.L., O.A., A.H., A.B., P.G., K.Y., T.W., M.Z., W.-Y.Y., and R.K.R. wrote the supporting information.
Reviewers: J.-P.H., Ecole Polytechnique Fédérale de Lausanne; B.A.M., Vanderbilt University; and E.V., University of Zurich.
Conflict of interest statement: The authors are employees of and own equity in Human Longevity Inc.
Data deposition: Access to genome data is possible through a managed access agreement (www.hli-opendata.com/docs/HLIDataAccessAgreement061617.docx).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1711125114/-/DCSupplemental.
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