Table of Contents

Biological Sciences

• Agricultural Sciences

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    Engineering sulfur storage in maize seed proteins without apparent yield loss

    Jose Planta, Xiaoli Xiang, Thomas Leustek, and Joachim Messing

    PNAS October 24, 2017 114 (43) 11386-11391; first published October 9, 2017. https://doi.org/10.1073/pnas.1714805114

• Biochemistry

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    Mechanistic principles underlying regulation of the actin cytoskeleton by phosphoinositides

    Yosuke Senju, Maria Kalimeri, Essi V. Koskela, Pentti Somerharju, Hongxia Zhao, Ilpo Vattulainen, and Pekka Lappalainen

    PNAS October 24, 2017 114 (43) E8977-E8986; first published October 9, 2017. https://doi.org/10.1073/pnas.1705032114
  • Open Access

    Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

    Matthew J. Shurtleff, Jun Yao, Yidan Qin, Ryan M. Nottingham, Morayma M. Temoche-Diaz, Randy Schekman, and Alan M. Lambowitz

    PNAS October 24, 2017 114 (43) E8987-E8995; first published October 10, 2017. https://doi.org/10.1073/pnas.1712108114
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    Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

    Elizaveta S. Leshchiner, Jason S. Rush, Michael A. Durney, Zhifang Cao, Vlado Dančík, Benjamin Chittick, Huixian Wu, Adam Petrone, Joshua A. Bittker, Andrew Phillips, Jose R. Perez, Alykhan F. Shamji, Virendar K. Kaushik, Mark J. Daly, Daniel B. Graham, Stuart L. Schreiber, and Ramnik J. Xavier

    PNAS October 24, 2017 114 (43) 11392-11397; first published October 9, 2017. https://doi.org/10.1073/pnas.1705748114
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    PrimPol is required for replication reinitiation after mtDNA damage

    Rubén Torregrosa-Muñumer, Josefin M. E. Forslund, Steffi Goffart, Annika Pfeiffer, Gorazd Stojkovič, Gustavo Carvalho, Natalie Al-Furoukh, Luis Blanco, Sjoerd Wanrooij, and Jaakko L. O. Pohjoismäki

    PNAS October 24, 2017 114 (43) 11398-11403; first published October 9, 2017. https://doi.org/10.1073/pnas.1705367114
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    Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

    Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie K. Jeong, Sophia Hsin-Jung Li, Adam Friedman, Mark G. Manfredi, Zemer Gitai, Hahn Kim, and Joshua D. Rabinowitz

    PNAS October 24, 2017 114 (43) 11404-11409; first published October 9, 2017. https://doi.org/10.1073/pnas.1706617114

• Biophysics and Computational Biology

  • Open Access

    Nonequilibrium fluctuations of lipid membranes by the rotating motor protein F₁F₀-ATP synthase

    Víctor G. Almendro-Vedia, Paolo Natale, Michael Mell, Stephanie Bonneau, Francisco Monroy, Frederic Joubert, and Iván López-Montero

    PNAS October 24, 2017 114 (43) 11291-11296; first published October 9, 2017. https://doi.org/10.1073/pnas.1701207114
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    Pressure effects on collective density fluctuations in water and protein solutions

    Daniela Russo, Alessio Laloni, Alessandra Filabozzi, and Matthias Heyden

    PNAS October 24, 2017 114 (43) 11410-11415; first published October 9, 2017. https://doi.org/10.1073/pnas.1705279114
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    Multiple interactions between an Arf/GEF complex and charged lipids determine activation kinetics on the membrane

    • From the Cover

    Deepti Karandur, Agata Nawrotek, John Kuriyan, and Jacqueline Cherfils

    PNAS October 24, 2017 114 (43) 11416-11421; first published September 18, 2017. https://doi.org/10.1073/pnas.1707970114

    See companion article:

    • Arf/Brag2 lipid coding

      - Oct 12, 2017
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    Molecular basis for unique specificity of human TRAF4 for platelets GPIbβ and GPVI

    Chang Min Kim, Young-Jin Son, Sunghwan Kim, Seo Yun Kim, and Hyun Ho Park

    PNAS October 24, 2017 114 (43) 11422-11427; first published October 10, 2017. https://doi.org/10.1073/pnas.1708688114
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    Self-association of a highly charged arginine-rich cell-penetrating peptide

    Giulio Tesei, Mario Vazdar, Malene Ringkjøbing Jensen, Carolina Cragnell, Phil E. Mason, Jan Heyda, Marie Skepö, Pavel Jungwirth, and Mikael Lund

    PNAS October 24, 2017 114 (43) 11428-11433; first published October 11, 2017. https://doi.org/10.1073/pnas.1712078114
  • Open Access

    Evidence of evolutionary selection for cotranslational folding

    William M. Jacobs and Eugene I. Shakhnovich

    PNAS October 24, 2017 114 (43) 11434-11439; first published October 10, 2017. https://doi.org/10.1073/pnas.1705772114

• Cell Biology

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    Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence

    Antoine de Morrée, Cindy T. J. van Velthoven, Qiang Gan, Jayesh S. Salvi, Julian D. D. Klein, Igor Akimenko, Marco Quarta, Stefano Biressi, and Thomas A. Rando

    PNAS October 24, 2017 114 (43) E8996-E9005; first published October 9, 2017. https://doi.org/10.1073/pnas.1708725114
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    Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy

    Tania Zaglia, Paola Ceriotti, Antonio Campo, Giulia Borile, Andrea Armani, Pierluigi Carullo, Valentina Prando, Raffaele Coppini, Vladimiro Vida, Tomas O. Stølen, Wisløff Ulrik, Elisabetta Cerbai, Giovanni Stellin, Giuseppe Faggian, Diego De Stefani, Marco Sandri, Rosario Rizzuto, Fabio Di Lisa, Tullio Pozzan, Daniele Catalucci, and Marco Mongillo

    PNAS October 24, 2017 114 (43) E9006-E9015; first published October 9, 2017. https://doi.org/10.1073/pnas.1708772114
  • Open Access

    Intragenic DNA methylation and BORIS-mediated cancer-specific splicing contribute to the Warburg effect

    Smriti Singh, Sathiya Pandi Narayanan, Kajal Biswas, Amit Gupta, Neha Ahuja, Sandhya Yadav, Rajendra Kumar Panday, Atul Samaiya, Shyam K. Sharan, and Sanjeev Shukla

    PNAS October 24, 2017 114 (43) 11440-11445; first published October 9, 2017. https://doi.org/10.1073/pnas.1708447114

• Developmental Biology

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    Modulation of apoptotic response by LAR family phosphatases–cIAP1 signaling during urinary tract morphogenesis

    Katherine Stewart, You Chi Tang, Maxwell E. R. Shafer, Adda-Lee Graham-Paquin, and Maxime Bouchard

    PNAS October 24, 2017 114 (43) E9016-E9025; first published October 9, 2017. https://doi.org/10.1073/pnas.1707229114

• Ecology

  • Open Access

    Diel cycling and long-term persistence of viruses in the ocean’s euphotic zone

    Frank O. Aylward, Dominique Boeuf, Daniel R. Mende, Elisha M. Wood-Charlson, Alice Vislova, John M. Eppley, Anna E. Romano, and Edward F. DeLong

    PNAS October 24, 2017 114 (43) 11446-11451; first published October 11, 2017. https://doi.org/10.1073/pnas.1714821114
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    Phylogenetic diversity anomaly in angiosperms between eastern Asia and eastern North America

    Hong Qian, Yi Jin, and Robert E. Ricklefs

    PNAS October 24, 2017 114 (43) 11452-11457; first published October 9, 2017. https://doi.org/10.1073/pnas.1703985114
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    Soilborne fungi have host affinity and host-specific effects on seed germination and survival in a lowland tropical forest

    Carolina Sarmiento, Paul-Camilo Zalamea, James W. Dalling, Adam S. Davis, Simon M. Stump, Jana M. U’Ren, and A. Elizabeth Arnold

    PNAS October 24, 2017 114 (43) 11458-11463; first published October 2, 2017. https://doi.org/10.1073/pnas.1706324114
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    Competitive network determines the direction of the diversity–function relationship

    Daniel S. Maynard, Thomas W. Crowther, and Mark A. Bradford

    PNAS October 24, 2017 114 (43) 11464-11469; first published October 9, 2017. https://doi.org/10.1073/pnas.1712211114

• Environmental Sciences

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    Bird specimens track 135 years of atmospheric black carbon and environmental policy

    Shane G. DuBay and Carl C. Fuldner

    PNAS October 24, 2017 114 (43) 11321-11326; first published October 9, 2017. https://doi.org/10.1073/pnas.1710239114

• Evolution

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    Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria

    Alejandro Couce, Larissa Viraphong Caudwell, Christoph Feinauer, Thomas Hindré, Jean-Paul Feugeas, Martin Weigt, Richard E. Lenski, Dominique Schneider, and Olivier Tenaillon

    PNAS October 24, 2017 114 (43) E9026-E9035; first published October 10, 2017. https://doi.org/10.1073/pnas.1705887114
  • Open Access

    Kinship and familiarity mitigate costs of social conflict between Seychelles warbler neighbors

    Kat Bebbington, Sjouke A. Kingma, Eleanor A. Fairfield, Hannah L. Dugdale, Jan Komdeur, Lewis G. Spurgin, and David S. Richardson

    PNAS October 24, 2017 114 (43) E9036-E9045; first published October 9, 2017. https://doi.org/10.1073/pnas.1704350114
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    Insight into the growth pattern and bone fusion of basal birds from an Early Cretaceous enantiornithine bird

    Min Wang, Zhiheng Li, and Zhonghe Zhou

    PNAS October 24, 2017 114 (43) 11470-11475; first published October 9, 2017. https://doi.org/10.1073/pnas.1707237114

• Genetics

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    UTX-guided neural crest function underlies craniofacial features of Kabuki syndrome

    Karl B. Shpargel, Joshua Starmer, Chaochen Wang, Kai Ge, and Terry Magnuson

    PNAS October 24, 2017 114 (43) E9046-E9055; first published October 9, 2017. https://doi.org/10.1073/pnas.1705011114
  • Open Access

    FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs

    • From the Cover

    Emily A. Brown, Peter J. Dickinson, Tamer Mansour, Beverly K. Sturges, Miriam Aguilar, Amy E. Young, Courtney Korff, Jenna Lind, Cassandra L. Ettinger, Samuel Varon, Rachel Pollard, C. Titus Brown, Terje Raudsepp, and Danika L. Bannasch

    PNAS October 24, 2017 114 (43) 11476-11481; first published October 11, 2017. https://doi.org/10.1073/pnas.1709082114

• Immunology and Inflammation

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    Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation

    Dorien Van hede, Barbara Polese, Chantal Humblet, Anneke Wilharm, Virginie Renoux, Estelle Dortu, Laurence de Leval, Philippe Delvenne, Christophe J. Desmet, Fabrice Bureau, David Vermijlen, and Nathalie Jacobs

    PNAS October 24, 2017 114 (43) E9056-E9065; first published October 10, 2017. https://doi.org/10.1073/pnas.1712883114
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    Selective neutralization of IL-12 p40 monomer induces death in prostate cancer cells via IL-12–IFN-γ

    Madhuchhanda Kundu, Avik Roy, and Kalipada Pahan

    PNAS October 24, 2017 114 (43) 11482-11487; first published October 9, 2017. https://doi.org/10.1073/pnas.1705536114

• Medical Sciences

  • Open Access

    Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

    Pasquale Sansone, Claudia Savini, Ivana Kurelac, Qing Chang, Laura Benedetta Amato, Antonio Strillacci, Anna Stepanova, Luisa Iommarini, Chiara Mastroleo, Laura Daly, Alexander Galkin, Basant Kumar Thakur, Nadine Soplop, Kunihiro Uryu, Ayuko Hoshino, Larry Norton, Massimiliano Bonafé, Monica Cricca, Giuseppe Gasparre, David Lyden, and Jacqueline Bromberg

    PNAS October 24, 2017 114 (43) E9066-E9075; first published October 11, 2017. https://doi.org/10.1073/pnas.1704862114
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    Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen

    Megan E. Spurgeon, Johan A. den Boon, Mark Horswill, Sonalee Barthakur, Omid Forouzan, Janet S. Rader, David J. Beebe, Avtar Roopra, Paul Ahlquist, and Paul F. Lambert

    PNAS October 24, 2017 114 (43) E9076-E9085; first published October 9, 2017. https://doi.org/10.1073/pnas.1712018114
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    PAF promotes stemness and radioresistance of glioma stem cells

    Derrick Sek Tong Ong, Baoli Hu, Yan Wing Ho, Charles-Etienne Gabriel Sauvé, Christopher A. Bristow, Qianghu Wang, Asha S. Multani, Peiwen Chen, Luigi Nezi, Shan Jiang, Claire Elizabeth Gorman, Marta Moreno Monasterio, Dimpy Koul, Matteo Marchesini, Simona Colla, Eun-Jung Jin, Erik P. Sulman, Denise J. Spring, Wai-Kwan Alfred Yung, Roel G. W. Verhaak, Lynda Chin, Y. Alan Wang, and Ronald A. DePinho

    PNAS October 24, 2017 114 (43) E9086-E9095; first published October 9, 2017. https://doi.org/10.1073/pnas.1708122114
  • Open Access

    Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

    Alexander G. Bick, Hiroko Wakimoto, Kimberli J. Kamer, Yasemin Sancak, Olga Goldberger, Anna Axelsson, Daniel M. DeLaughter, Joshua M. Gorham, Vamsi K. Mootha, J. G. Seidman, and Christine E. Seidman

    PNAS October 24, 2017 114 (43) E9096-E9104; first published October 9, 2017. https://doi.org/10.1073/pnas.1711303114
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    SMELL-S and SMELL-R: Olfactory tests not influenced by odor-specific insensitivity or prior olfactory experience

    • Inaugural Article

    Julien W. Hsieh, Andreas Keller, Michele Wong, Rong-San Jiang, and Leslie B. Vosshall

    PNAS October 24, 2017 114 (43) 11275-11284; first published October 10, 2017. https://doi.org/10.1073/pnas.1711415114
  • Open Access

    Big data modeling to predict platelet usage and minimize wastage in a tertiary care system

    Leying Guan, Xiaoying Tian, Saurabh Gombar, Allison J. Zemek, Gomathi Krishnan, Robert Scott, Balasubramanian Narasimhan, Robert J. Tibshirani, and Tho D. Pham

    PNAS October 24, 2017 114 (43) 11368-11373; first published October 9, 2017. https://doi.org/10.1073/pnas.1714097114
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    Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

    Soracha Thamphiwatana, Pavimol Angsantikul, Tamara Escajadillo, Qiangzhe Zhang, Joshua Olson, Brian T. Luk, Sophia Zhang, Ronnie H. Fang, Weiwei Gao, Victor Nizet, and Liangfang Zhang

    PNAS October 24, 2017 114 (43) 11488-11493; first published October 9, 2017. https://doi.org/10.1073/pnas.1714267114
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    Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice

    Yixiang Xu, Dong-Kee Lee, Zhen Feng, Yan Xu, Wen Bu, Yi Li, Lan Liao, and Jianming Xu

    PNAS October 24, 2017 114 (43) 11494-11499; first published October 9, 2017. https://doi.org/10.1073/pnas.1618091114
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    Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner

    Hee Jung Yang, Jin Zhang, Wensheng Yan, Seong-Jun Cho, Christopher Lucchesi, Mingyi Chen, Eric C. Huang, Ariane Scoumanne, Weici Zhang, and Xinbin Chen

    PNAS October 24, 2017 114 (43) 11500-11505; first published October 9, 2017. https://doi.org/10.1073/pnas.1711814114

• Microbiology

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    Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice

    • From the Cover

    Jessica L. Mark Welch, Yuko Hasegawa, Nathan P. McNulty, Jeffrey I. Gordon, and Gary G. Borisy

    PNAS October 24, 2017 114 (43) E9105-E9114; first published October 9, 2017. https://doi.org/10.1073/pnas.1711596114
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    Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

    Heather Koehler, Samantha Cotsmire, Jeffrey Langland, Karen V. Kibler, Daniel Kalman, Jason W. Upton, Edward S. Mocarski, and Bertram L. Jacobs

    PNAS October 24, 2017 114 (43) 11506-11511; first published October 9, 2017. https://doi.org/10.1073/pnas.1700999114
  • Open Access

    Maladaptive DNA repair is the ultimate contributor to the death of trimethoprim-treated cells under aerobic and anaerobic conditions

    Xavier Giroux, Wei-Lin Su, Marie-Florence Bredeche, and Ivan Matic

    PNAS October 24, 2017 114 (43) 11512-11517; first published October 9, 2017. https://doi.org/10.1073/pnas.1706236114

• Neuroscience

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    Visual perception as retrospective Bayesian decoding from high- to low-level features

    Stephanie Ding, Christopher J. Cueva, Misha Tsodyks, and Ning Qian

    PNAS October 24, 2017 114 (43) E9115-E9124; first published October 9, 2017. https://doi.org/10.1073/pnas.1706906114
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    Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula

    Daniel C. Castro and Kent C. Berridge

    PNAS October 24, 2017 114 (43) E9125-E9134; first published October 9, 2017. https://doi.org/10.1073/pnas.1705753114
  • Open Access

    M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory

    Claude-Henry Volmar, Hasib Salah-Uddin, Karolina J. Janczura, Paul Halley, Guerline Lambert, Andrew Wodrich, Sivan Manoah, Nidhi H. Patel, Gregory C. Sartor, Neil Mehta, Nancy T. H. Miles, Sachi Desse, David Dorcius, Michael D. Cameron, Shaun P. Brothers, and Claes Wahlestedt

    PNAS October 24, 2017 114 (43) E9135-E9144; first published October 9, 2017. https://doi.org/10.1073/pnas.1707544114
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    Perceiving social interactions in the posterior superior temporal sulcus

    Leyla Isik, Kami Koldewyn, David Beeler, and Nancy Kanwisher

    PNAS October 24, 2017 114 (43) E9145-E9152; first published October 9, 2017. https://doi.org/10.1073/pnas.1714471114
  • Open Access

    Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo

    Amy L. Herbert, Meng-meng Fu, Catherine M. Drerup, Ryan S. Gray, Breanne L. Harty, Sarah D. Ackerman, Thomas O’Reilly-Pol, Stephen L. Johnson, Alex V. Nechiporuk, Ben A. Barres, and Kelly R. Monk

    PNAS October 24, 2017 114 (43) E9153-E9162; first published October 12, 2017. https://doi.org/10.1073/pnas.1711088114
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    Local synaptic integration enables ON-OFF asymmetric and layer-specific visual information processing in vGluT3 amacrine cell dendrites

    • From the Cover

    Minggang Chen, Seunghoon Lee, and Z. Jimmy Zhou

    PNAS October 24, 2017 114 (43) 11518-11523; first published September 27, 2017. https://doi.org/10.1073/pnas.1711622114

    See companion article:

    • Dendritic computation by a multitasking neuron

      - Oct 12, 2017
  • Open Access

    TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

    Cheryl E. G. Leyns, Jason D. Ulrich, Mary B. Finn, Floy R. Stewart, Lauren J. Koscal, Javier Remolina Serrano, Grace O. Robinson, Elise Anderson, Marco Colonna, and David M. Holtzman

    PNAS October 24, 2017 114 (43) 11524-11529; first published October 9, 2017. https://doi.org/10.1073/pnas.1710311114

• Pharmacology

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    β₂-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility

    Long P. Nguyen, Nour A. Al-Sawalha, Sergio Parra, Indira Pokkunuri, Ozozoma Omoluabi, Adedoyin A. Okulate, Elizabeth Windham Li, Matthew Hazen, Jose M. Gonzalez-Granado, Craig J. Daly, John C. McGrath, Michael J. Tuvim, Brian J. Knoll, Burton F. Dickey, and Richard A. Bond

    PNAS October 24, 2017 114 (43) E9163-E9171; first published October 9, 2017. https://doi.org/10.1073/pnas.1710196114

• Physiology

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    Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms

    Giuseppe Ferrandino, Rachel R. Kaspari, Olga Spadaro, Andrea Reyna-Neyra, Rachel J. Perry, Rebecca Cardone, Richard G. Kibbey, Gerald I. Shulman, Vishwa Deep Dixit, and Nancy Carrasco

    PNAS October 24, 2017 114 (43) E9172-E9180; first published October 10, 2017. https://doi.org/10.1073/pnas.1707797114
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    Transcription factor ISX mediates the cross talk between diet and immunity

    Made Airanthi K. Widjaja-Adhi, Grzegorz Palczewski, Kali Dale, Elizabeth A. Knauss, Mary E. Kelly, Marcin Golczak, Alan D. Levine, and Johannes von Lintig

    PNAS October 24, 2017 114 (43) 11530-11535; first published October 9, 2017. https://doi.org/10.1073/pnas.1714963114

• Plant Biology

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    Natural variation identifies genes affecting drought-induced abscisic acid accumulation in Arabidopsis thaliana

    Rajesh Kalladan, Jesse R. Lasky, Trent Z. Chang, Sandeep Sharma, Thomas E. Juenger, and Paul E. Verslues

    PNAS October 24, 2017 114 (43) 11536-11541; first published October 10, 2017. https://doi.org/10.1073/pnas.1705884114

• Psychological and Cognitive Sciences

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    Disruption and rescue of interareal theta phase coupling and adaptive behavior

    Robert M. G. Reinhart

    PNAS October 24, 2017 114 (43) 11542-11547; first published October 9, 2017. https://doi.org/10.1073/pnas.1710257114

• Systems Biology

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    Thermosensitivity of growth is determined by chaperone-mediated proteome reallocation

    Ke Chen, Ye Gao, Nathan Mih, Edward J. O’Brien, Laurence Yang, and Bernhard O. Palsson

    PNAS October 24, 2017 114 (43) 11548-11553; first published October 10, 2017. https://doi.org/10.1073/pnas.1705524114