Proceedings of the National Academy of Sciences: 114 (51)

Introduction
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  Chemical physics of water
  Pablo G. Debenedetti and Michael L. Klein
  
  PNAS December 19, 2017 114 (51) 13325-13326; first published December 11, 2017. https://doi.org/10.1073/pnas.1719350115
Perspectives
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  Water is an active matrix of life for cell and molecular biology
  Philip Ball
  
  PNAS December 19, 2017 114 (51) 13327-13335; first published June 7, 2017. https://doi.org/10.1073/pnas.1703781114
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  Supercooled and glassy water: Metastable liquid(s), amorphous solid(s), and a no-man’s land
  Philip H. Handle, Thomas Loerting, and Francesco Sciortino
  
  PNAS December 19, 2017 114 (51) 13336-13344; first published November 13, 2017. https://doi.org/10.1073/pnas.1700103114
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  Solar thermochemical splitting of water to generate hydrogen
  C. N. R. Rao and Sunita Dey
  
  PNAS December 19, 2017 114 (51) 13385-13393; first published May 18, 2017. https://doi.org/10.1073/pnas.1700104114
Research Articles
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  Hydrophobicity of proteins and nanostructured solutes is governed by topographical and chemical context
  Erte Xi, Vasudevan Venkateshwaran, Lijuan Li, Nicholas Rego, Amish J. Patel, and Shekhar Garde
  
  PNAS December 19, 2017 114 (51) 13345-13350; first published November 20, 2017. https://doi.org/10.1073/pnas.1700092114
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  Molecular characterization of water and surfactant AOT at nanoemulsion surfaces
  From the Cover
  
  Jennifer K. Hensel, Andrew P. Carpenter, Regina K. Ciszewski, Brandon K. Schabes, Clive T. Kittredge, Fred G. Moore, and Geraldine L. Richmond
  
  PNAS December 19, 2017 114 (51) 13351-13356; first published July 31, 2017. https://doi.org/10.1073/pnas.1700099114
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  XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction
  Jessica L. Thomaston, Rahel A. Woldeyes, Takanori Nakane, Ayumi Yamashita, Tomoyuki Tanaka, Kotaro Koiwai, Aaron S. Brewster, Benjamin A. Barad, Yujie Chen, Thomas Lemmin, Monarin Uervirojnangkoorn, Toshi Arima, Jun Kobayashi, Tetsuya Masuda, Mamoru Suzuki, Michihiro Sugahara, Nicholas K. Sauter, Rie Tanaka, Osamu Nureki, Kensuke Tono, Yasumasa Joti, Eriko Nango, So Iwata, Fumiaki Yumoto, James S. Fraser, and William F. DeGrado
  
  PNAS December 19, 2017 114 (51) 13357-13362; first published August 23, 2017. https://doi.org/10.1073/pnas.1705624114
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  Specific cation effects at aqueous solution−vapor interfaces: Surfactant-like behavior of Li⁺ revealed by experiments and simulations
  Kathryn A. Perrine, Krista M. Parry, Abraham C. Stern, Marijke H. C. Van Spyk, Michael J. Makowski, J. Alfredo Freites, Bernd Winter, Douglas J. Tobias, and John C. Hemminger
  
  PNAS December 19, 2017 114 (51) 13363-13368; first published October 9, 2017. https://doi.org/10.1073/pnas.1707540114
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  Mechanism of ion adsorption to aqueous interfaces: Graphene/water vs. air/water
  Debra L. McCaffrey, Son C. Nguyen, Stephen J. Cox, Horst Weller, A. Paul Alivisatos, Phillip L. Geissler, and Richard J. Saykally
  
  PNAS December 19, 2017 114 (51) 13369-13373; first published August 21, 2017. https://doi.org/10.1073/pnas.1702760114
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  Microscopic dynamics of charge separation at the aqueous electrochemical interface
  John A. Kattirtzi, David T. Limmer, and Adam P. Willard
  
  PNAS December 19, 2017 114 (51) 13374-13379; first published July 11, 2017. https://doi.org/10.1073/pnas.1700093114
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  Self-healing catalysis in water
  Cyrille Costentin and Daniel G. Nocera
  
  PNAS December 19, 2017 114 (51) 13380-13384; first published September 5, 2017. https://doi.org/10.1073/pnas.1711836114

Physical Sciences

Biophysics and Computational Biology
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  XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction
  Jessica L. Thomaston, Rahel A. Woldeyes, Takanori Nakane, Ayumi Yamashita, Tomoyuki Tanaka, Kotaro Koiwai, Aaron S. Brewster, Benjamin A. Barad, Yujie Chen, Thomas Lemmin, Monarin Uervirojnangkoorn, Toshi Arima, Jun Kobayashi, Tetsuya Masuda, Mamoru Suzuki, Michihiro Sugahara, Nicholas K. Sauter, Rie Tanaka, Osamu Nureki, Kensuke Tono, Yasumasa Joti, Eriko Nango, So Iwata, Fumiaki Yumoto, James S. Fraser, and William F. DeGrado
  
  PNAS December 19, 2017 114 (51) 13357-13362; first published August 23, 2017. https://doi.org/10.1073/pnas.1705624114
- Open Access
  Structure and function of a compound eye, more than half a billion years old
  Brigitte Schoenemann, Helje Pärnaste, and Euan N. K. Clarkson
  
  PNAS December 19, 2017 114 (51) 13489-13494; first published December 4, 2017. https://doi.org/10.1073/pnas.1716824114
- You have access
  Crystal structure of human IRAK1
  Li Wang, Qi Qiao, Ryan Ferrao, Chen Shen, John M. Hatcher, Sara J. Buhrlage, Nathanael S. Gray, and Hao Wu
  
  PNAS December 19, 2017 114 (51) 13507-13512; first published December 5, 2017. https://doi.org/10.1073/pnas.1714386114
Chemistry
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  Extending density functional embedding theory for covalently bonded systems
  Kuang Yu and Emily A. Carter
  
  PNAS December 19, 2017 114 (51) E10861-E10870; first published December 4, 2017. https://doi.org/10.1073/pnas.1712611114
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  CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains
  From the Cover
  
  Andrew Chancellor, Anna S. Tocheva, Chris Cave-Ayland, Liku Tezera, Andrew White, Juma’a R. Al Dulayymi, John S. Bridgeman, Ivo Tews, Susan Wilson, Nikolai M. Lissin, Marc Tebruegge, Ben Marshall, Sally Sharpe, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Mark S. Baird, Stephan Gadola, Paul Elkington, and Salah Mansour
  
  PNAS December 19, 2017 114 (51) E10956-E10964; first published November 20, 2017. https://doi.org/10.1073/pnas.1708252114
  
  See companion article:
  Grasping mycobacterial lipid antigens
  - Dec 07, 2017
- You have access
  Hydrophobicity of proteins and nanostructured solutes is governed by topographical and chemical context
  Erte Xi, Vasudevan Venkateshwaran, Lijuan Li, Nicholas Rego, Amish J. Patel, and Shekhar Garde
  
  PNAS December 19, 2017 114 (51) 13345-13350; first published November 20, 2017. https://doi.org/10.1073/pnas.1700092114
- You have access
  Molecular characterization of water and surfactant AOT at nanoemulsion surfaces
  From the Cover
  
  Jennifer K. Hensel, Andrew P. Carpenter, Regina K. Ciszewski, Brandon K. Schabes, Clive T. Kittredge, Fred G. Moore, and Geraldine L. Richmond
  
  PNAS December 19, 2017 114 (51) 13351-13356; first published July 31, 2017. https://doi.org/10.1073/pnas.1700099114
- You have access
  Specific cation effects at aqueous solution−vapor interfaces: Surfactant-like behavior of Li⁺ revealed by experiments and simulations
  Kathryn A. Perrine, Krista M. Parry, Abraham C. Stern, Marijke H. C. Van Spyk, Michael J. Makowski, J. Alfredo Freites, Bernd Winter, Douglas J. Tobias, and John C. Hemminger
  
  PNAS December 19, 2017 114 (51) 13363-13368; first published October 9, 2017. https://doi.org/10.1073/pnas.1707540114
- You have access
  Mechanism of ion adsorption to aqueous interfaces: Graphene/water vs. air/water
  Debra L. McCaffrey, Son C. Nguyen, Stephen J. Cox, Horst Weller, A. Paul Alivisatos, Phillip L. Geissler, and Richard J. Saykally
  
  PNAS December 19, 2017 114 (51) 13369-13373; first published August 21, 2017. https://doi.org/10.1073/pnas.1702760114
- You have access
  Microscopic dynamics of charge separation at the aqueous electrochemical interface
  John A. Kattirtzi, David T. Limmer, and Adam P. Willard
  
  PNAS December 19, 2017 114 (51) 13374-13379; first published July 11, 2017. https://doi.org/10.1073/pnas.1700093114
- You have access
  Self-healing catalysis in water
  Cyrille Costentin and Daniel G. Nocera
  
  PNAS December 19, 2017 114 (51) 13380-13384; first published September 5, 2017. https://doi.org/10.1073/pnas.1711836114
- Open Access
  Metabolic activity induces membrane phase separation in endoplasmic reticulum
  Yihui Shen, Zhilun Zhao, Luyuan Zhang, Lingyan Shi, Sanjid Shahriar, Robin B. Chan, Gilbert Di Paolo, and Wei Min
  
  PNAS December 19, 2017 114 (51) 13394-13399; first published December 1, 2017. https://doi.org/10.1073/pnas.1712555114
- Open Access
  Electrostatic confinement and manipulation of DNA molecules for genome analysis
  Kristy L. Kounovsky-Shafer, Juan P. Hernandez-Ortiz, Konstantinos Potamousis, Gene Tsvid, Michael Place, Prabu Ravindran, Kyubong Jo, Shiguo Zhou, Theo Odijk, Juan J. de Pablo, and David C. Schwartz
  
  PNAS December 19, 2017 114 (51) 13400-13405; first published December 4, 2017. https://doi.org/10.1073/pnas.1711069114
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  Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors
  Nicholas J. Porter, Adaickapillai Mahendran, Ronald Breslow, and David W. Christianson
  
  PNAS December 19, 2017 114 (51) 13459-13464; first published December 4, 2017. https://doi.org/10.1073/pnas.1718823114
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  Superhydrophobic diving flies (Ephydra hians) and the hypersaline waters of Mono Lake
  Floris van Breugel and Michael H. Dickinson
  
  PNAS December 19, 2017 114 (51) 13483-13488; first published November 20, 2017. https://doi.org/10.1073/pnas.1714874114
Earth, Atmospheric, and Planetary Sciences
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  Percolative core formation in planetesimals enabled by hysteresis in metal connectivity
  Soheil Ghanbarzadeh, Marc A. Hesse, and Maša Prodanović
  
  PNAS December 19, 2017 114 (51) 13406-13411; first published December 4, 2017. https://doi.org/10.1073/pnas.1707580114
Engineering
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  Effect of removing Kupffer cells on nanoparticle tumor delivery
  Anthony J. Tavares, Wilson Poon, Yi-Nan Zhang, Qin Dai, Rickvinder Besla, Ding Ding, Ben Ouyang, Angela Li, Juan Chen, Gang Zheng, Clinton Robbins, and Warren C. W. Chan
  
  PNAS December 19, 2017 114 (51) E10871-E10880; first published December 5, 2017. https://doi.org/10.1073/pnas.1713390114
- Open Access
  Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings
  Pelham A. Keahey, Mathieu L. Simeral, Kristofer J. Schroder, Meaghan M. Bond, Prince J. Mtenthaonnga, Robert H. Miros, Queen Dube, and Rebecca R. Richards-Kortum
  
  PNAS December 19, 2017 114 (51) E10965-E10971; first published December 4, 2017. https://doi.org/10.1073/pnas.1714020114
- Open Access
  Terminal attack trajectories of peregrine falcons are described by the proportional navigation guidance law of missiles
  Caroline H. Brighton, Adrian L. R. Thomas, and Graham K. Taylor
  
  PNAS December 19, 2017 114 (51) 13495-13500; first published December 4, 2017. https://doi.org/10.1073/pnas.1714532114
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  Rapid diagnostic testing platform for iron and vitamin A deficiency
  Zhengda Lu, Dakota O’Dell, Balaji Srinivasan, Elizabeth Rey, Ruisheng Wang, Sasank Vemulapati, Saurabh Mehta, and David Erickson
  
  PNAS December 19, 2017 114 (51) 13513-13518; first published December 4, 2017. https://doi.org/10.1073/pnas.1711464114
Environmental Sciences
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  Mapping local and global variability in plant trait distributions
  Ethan E. Butler, Abhirup Datta, Habacuc Flores-Moreno, Ming Chen, Kirk R. Wythers, Farideh Fazayeli, Arindam Banerjee, Owen K. Atkin, Jens Kattge, Bernard Amiaud, Benjamin Blonder, Gerhard Boenisch, Ben Bond-Lamberty, Kerry A. Brown, Chaeho Byun, Giandiego Campetella, Bruno E. L. Cerabolini, Johannes H. C. Cornelissen, Joseph M. Craine, Dylan Craven, Franciska T. de Vries, Sandra Díaz, Tomas F. Domingues, Estelle Forey, Andrés González-Melo, Nicolas Gross, Wenxuan Han, Wesley N. Hattingh, Thomas Hickler, Steven Jansen, Koen Kramer, Nathan J. B. Kraft, Hiroko Kurokawa, Daniel C. Laughlin, Patrick Meir, Vanessa Minden, Ülo Niinemets, Yusuke Onoda, Josep Peñuelas, Quentin Read, Lawren Sack, Brandon Schamp, Nadejda A. Soudzilovskaia, Marko J. Spasojevic, Enio Sosinski, Peter E. Thornton, Fernando Valladares, Peter M. van Bodegom, Mathew Williams, Christian Wirth, and Peter B. Reich
  
  PNAS December 19, 2017 114 (51) E10937-E10946; first published December 1, 2017. https://doi.org/10.1073/pnas.1708984114
- Open Access
  Evaluating the environmental impacts of dietary recommendations
  Paul Behrens, Jessica C. Kiefte-de Jong, Thijs Bosker, João F. D. Rodrigues, Arjan de Koning, and Arnold Tukker
  
  PNAS December 19, 2017 114 (51) 13412-13417; first published December 4, 2017. https://doi.org/10.1073/pnas.1711889114
Mathematics
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  What Chern–Simons theory assigns to a point
  André G. Henriques
  
  PNAS December 19, 2017 114 (51) 13418-13423; first published December 5, 2017. https://doi.org/10.1073/pnas.1711591114
Physics
- Open Access
  Dynamics of translation can determine the spatial organization of membrane-bound proteins and their mRNA
  Elgin Korkmazhan, Hamid Teimouri, Neil Peterman, and Erel Levine
  
  PNAS December 19, 2017 114 (51) 13424-13429; first published December 4, 2017. https://doi.org/10.1073/pnas.1700941114
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  Transverse fields to tune an Ising-nematic quantum phase transition
  Akash V. Maharaj, Elliott W. Rosenberg, Alexander T. Hristov, Erez Berg, Rafael M. Fernandes, Ian R. Fisher, and Steven A. Kivelson
  
  PNAS December 19, 2017 114 (51) 13430-13434; first published December 5, 2017. https://doi.org/10.1073/pnas.1712533114

Biological Sciences

Applied Biological Sciences
- Open Access
  Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
  Heng-Hong Li, Renxiang Chen, Daniel R. Hyduke, Andrew Williams, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Raegan O’Lone, Carole L. Yauk, Jiri Aubrecht, and Albert J. Fornace Jr.
  
  PNAS December 19, 2017 114 (51) E10881-E10889; first published December 4, 2017. https://doi.org/10.1073/pnas.1714109114
Biochemistry
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  Structural insights into how GTP-dependent conformational changes in a metallochaperone UreG facilitate urease maturation
  Man Hon Yuen, Yu Hang Fong, Yap Shing Nim, Pak Ho Lau, and Kam-Bo Wong
  
  PNAS December 19, 2017 114 (51) E10890-E10898; first published December 4, 2017. https://doi.org/10.1073/pnas.1712658114
- Open Access
  Aminoglycoside interactions and impacts on the eukaryotic ribosome
  Irina Prokhorova, Roger B. Altman, Muminjon Djumagulov, Jaya P. Shrestha, Alexandre Urzhumtsev, Angelica Ferguson, Cheng-Wei Tom Chang, Marat Yusupov, Scott C. Blanchard, and Gulnara Yusupova
  
  PNAS December 19, 2017 114 (51) E10899-E10908; first published December 5, 2017. https://doi.org/10.1073/pnas.1715501114
- You have access
  Conserved salt-bridge competition triggered by phosphorylation regulates the protein interactome
  John J. Skinner, Sheng Wang, Jiyoung Lee, Colin Ong, Ruth Sommese, Sivaraj Sivaramakrishnan, Wolfgang Koelmel, Maria Hirschbeck, Hermann Schindelin, Caroline Kisker, Kristina Lorenz, Tobin R. Sosnick, and Marsha Rich Rosner
  
  PNAS December 19, 2017 114 (51) 13453-13458; first published December 5, 2017. https://doi.org/10.1073/pnas.1711543114
Biophysics and Computational Biology
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  pH-sensitive vibrational probe reveals a cytoplasmic protonated cluster in bacteriorhodopsin
  Victor A. Lorenz-Fonfria, Mattia Saita, Tzvetana Lazarova, Ramona Schlesinger, and Joachim Heberle
  
  PNAS December 19, 2017 114 (51) E10909-E10918; first published December 4, 2017. https://doi.org/10.1073/pnas.1707993114
- You have access
  Molecular chaperones maximize the native state yield on biological times by driving substrates out of equilibrium
  Shaon Chakrabarti, Changbong Hyeon, Xiang Ye, George H. Lorimer, and D. Thirumalai
  
  PNAS December 19, 2017 114 (51) E10919-E10927; first published December 7, 2017. https://doi.org/10.1073/pnas.1712962114
- Open Access
  Metabolic activity induces membrane phase separation in endoplasmic reticulum
  Yihui Shen, Zhilun Zhao, Luyuan Zhang, Lingyan Shi, Sanjid Shahriar, Robin B. Chan, Gilbert Di Paolo, and Wei Min
  
  PNAS December 19, 2017 114 (51) 13394-13399; first published December 1, 2017. https://doi.org/10.1073/pnas.1712555114
- Open Access
  Dynamics of translation can determine the spatial organization of membrane-bound proteins and their mRNA
  Elgin Korkmazhan, Hamid Teimouri, Neil Peterman, and Erel Levine
  
  PNAS December 19, 2017 114 (51) 13424-13429; first published December 4, 2017. https://doi.org/10.1073/pnas.1700941114
- You have access
  Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors
  Nicholas J. Porter, Adaickapillai Mahendran, Ronald Breslow, and David W. Christianson
  
  PNAS December 19, 2017 114 (51) 13459-13464; first published December 4, 2017. https://doi.org/10.1073/pnas.1718823114
Cell Biology
- You have access
  SCWISh network is essential for survival under mechanical pressure
  Morgan Delarue, Gregory Poterewicz, Ori Hoxha, Jessica Choi, Wonjung Yoo, Jona Kayser, Liam Holt, and Oskar Hallatschek
  
  PNAS December 19, 2017 114 (51) 13465-13470; first published November 29, 2017. https://doi.org/10.1073/pnas.1711204114
  
  See companion article:
  Mechanotransduction in yeast
  - Dec 01, 2017
- You have access
  Protein kinase C and calcineurin cooperatively mediate cell survival under compressive mechanical stress
  Ranjan Mishra, Frank van Drogen, Reinhard Dechant, Soojung Oh, Noo Li Jeon, Sung Sik Lee, and Matthias Peter
  
  PNAS December 19, 2017 114 (51) 13471-13476; first published December 1, 2017. https://doi.org/10.1073/pnas.1709079114
  
  See companion article:
  Mechanosensitive SCWISh network
  - Nov 29, 2017
- You have access
  Gα_s protein binds ubiquitin to regulate epidermal growth factor receptor endosomal sorting
  Xuezhi Li, Danny Létourneau, Brian Holleran, Richard Leduc, Pierre Lavigne, and Christine Lavoie
  
  PNAS December 19, 2017 114 (51) 13477-13482; first published November 30, 2017. https://doi.org/10.1073/pnas.1708215114
Developmental Biology
- Open Access
  STRIP1, a core component of STRIPAK complexes, is essential for normal mesoderm migration in the mouse embryo
  Hisham Bazzi, Ekaterina Soroka, Heather L. Alcorn, and Kathryn V. Anderson
  
  PNAS December 19, 2017 114 (51) E10928-E10936; first published December 4, 2017. https://doi.org/10.1073/pnas.1713535114
Ecology
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  Mapping local and global variability in plant trait distributions
  Ethan E. Butler, Abhirup Datta, Habacuc Flores-Moreno, Ming Chen, Kirk R. Wythers, Farideh Fazayeli, Arindam Banerjee, Owen K. Atkin, Jens Kattge, Bernard Amiaud, Benjamin Blonder, Gerhard Boenisch, Ben Bond-Lamberty, Kerry A. Brown, Chaeho Byun, Giandiego Campetella, Bruno E. L. Cerabolini, Johannes H. C. Cornelissen, Joseph M. Craine, Dylan Craven, Franciska T. de Vries, Sandra Díaz, Tomas F. Domingues, Estelle Forey, Andrés González-Melo, Nicolas Gross, Wenxuan Han, Wesley N. Hattingh, Thomas Hickler, Steven Jansen, Koen Kramer, Nathan J. B. Kraft, Hiroko Kurokawa, Daniel C. Laughlin, Patrick Meir, Vanessa Minden, Ülo Niinemets, Yusuke Onoda, Josep Peñuelas, Quentin Read, Lawren Sack, Brandon Schamp, Nadejda A. Soudzilovskaia, Marko J. Spasojevic, Enio Sosinski, Peter E. Thornton, Fernando Valladares, Peter M. van Bodegom, Mathew Williams, Christian Wirth, and Peter B. Reich
  
  PNAS December 19, 2017 114 (51) E10937-E10946; first published December 1, 2017. https://doi.org/10.1073/pnas.1708984114
- You have access
  Superhydrophobic diving flies (Ephydra hians) and the hypersaline waters of Mono Lake
  Floris van Breugel and Michael H. Dickinson
  
  PNAS December 19, 2017 114 (51) 13483-13488; first published November 20, 2017. https://doi.org/10.1073/pnas.1714874114
Evolution
- Open Access
  Structure and function of a compound eye, more than half a billion years old
  Brigitte Schoenemann, Helje Pärnaste, and Euan N. K. Clarkson
  
  PNAS December 19, 2017 114 (51) 13489-13494; first published December 4, 2017. https://doi.org/10.1073/pnas.1716824114
- Open Access
  Terminal attack trajectories of peregrine falcons are described by the proportional navigation guidance law of missiles
  Caroline H. Brighton, Adrian L. R. Thomas, and Graham K. Taylor
  
  PNAS December 19, 2017 114 (51) 13495-13500; first published December 4, 2017. https://doi.org/10.1073/pnas.1714532114
- You have access
  Rapid adaptive evolution in novel environments acts as an architect of population range expansion
  M. Szűcs, M. L. Vahsen, B. A. Melbourne, C. Hoover, C. Weiss-Lehman, and R. A. Hufbauer
  
  PNAS December 19, 2017 114 (51) 13501-13506; first published November 28, 2017. https://doi.org/10.1073/pnas.1712934114
Genetics
- Open Access
  Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous
  Wei-Jen Chung, Anneleen Daemen, Jason H. Cheng, Jason E. Long, Jonathan E. Cooper, Bu-er Wang, Christopher Tran, Mallika Singh, Florian Gnad, Zora Modrusan, Oded Foreman, and Melissa R. Junttila
  
  PNAS December 19, 2017 114 (51) E10947-E10955; first published December 4, 2017. https://doi.org/10.1073/pnas.1708391114
Immunology and Inflammation
- You have access
  CD1b-restricted GEM T cell responses are modulated by Mycobacterium tuberculosis mycolic acid meromycolate chains
  From the Cover
  
  Andrew Chancellor, Anna S. Tocheva, Chris Cave-Ayland, Liku Tezera, Andrew White, Juma’a R. Al Dulayymi, John S. Bridgeman, Ivo Tews, Susan Wilson, Nikolai M. Lissin, Marc Tebruegge, Ben Marshall, Sally Sharpe, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Mark S. Baird, Stephan Gadola, Paul Elkington, and Salah Mansour
  
  PNAS December 19, 2017 114 (51) E10956-E10964; first published November 20, 2017. https://doi.org/10.1073/pnas.1708252114
  
  See companion article:
  Grasping mycobacterial lipid antigens
  - Dec 07, 2017
- You have access
  Crystal structure of human IRAK1
  Li Wang, Qi Qiao, Ryan Ferrao, Chen Shen, John M. Hatcher, Sara J. Buhrlage, Nathanael S. Gray, and Hao Wu
  
  PNAS December 19, 2017 114 (51) 13507-13512; first published December 5, 2017. https://doi.org/10.1073/pnas.1714386114
Medical Sciences
- You have access
  Effect of removing Kupffer cells on nanoparticle tumor delivery
  Anthony J. Tavares, Wilson Poon, Yi-Nan Zhang, Qin Dai, Rickvinder Besla, Ding Ding, Ben Ouyang, Angela Li, Juan Chen, Gang Zheng, Clinton Robbins, and Warren C. W. Chan
  
  PNAS December 19, 2017 114 (51) E10871-E10880; first published December 5, 2017. https://doi.org/10.1073/pnas.1713390114
- Open Access
  Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings
  Pelham A. Keahey, Mathieu L. Simeral, Kristofer J. Schroder, Meaghan M. Bond, Prince J. Mtenthaonnga, Robert H. Miros, Queen Dube, and Rebecca R. Richards-Kortum
  
  PNAS December 19, 2017 114 (51) E10965-E10971; first published December 4, 2017. https://doi.org/10.1073/pnas.1714020114
- You have access
  DNA replication timing alterations identify common markers between distinct progeroid diseases
  Juan Carlos Rivera-Mulia, Romain Desprat, Claudia Trevilla-Garcia, Daniela Cornacchia, Hélène Schwerer, Takayo Sasaki, Jiao Sima, Tyler Fells, Lorenz Studer, Jean-Marc Lemaitre, and David M. Gilbert
  
  PNAS December 19, 2017 114 (51) E10972-E10980; first published December 1, 2017. https://doi.org/10.1073/pnas.1711613114
- You have access
  Epigenetic therapy activates type I interferon signaling in murine ovarian cancer to reduce immunosuppression and tumor burden
  Meredith L. Stone, Katherine B. Chiappinelli, Huili Li, Lauren M. Murphy, Meghan E. Travers, Michael J. Topper, Dimitrios Mathios, Michael Lim, Ie-Ming Shih, Tian-Li Wang, Chien-Fu Hung, Vipul Bhargava, Karla R. Wiehagen, Glenn S. Cowley, Kurtis E. Bachman, Reiner Strick, Pamela L. Strissel, Stephen B. Baylin, and Cynthia A. Zahnow
  
  PNAS December 19, 2017 114 (51) E10981-E10990; first published December 4, 2017. https://doi.org/10.1073/pnas.1712514114
  
  See companion article:
  Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic
  - Sep 04, 2018
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  Rapid diagnostic testing platform for iron and vitamin A deficiency
  Zhengda Lu, Dakota O’Dell, Balaji Srinivasan, Elizabeth Rey, Ruisheng Wang, Sasank Vemulapati, Saurabh Mehta, and David Erickson
  
  PNAS December 19, 2017 114 (51) 13513-13518; first published December 4, 2017. https://doi.org/10.1073/pnas.1711464114
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  Selected reaction monitoring approach for validating peptide biomarkers
  Qing Wang, Ming Zhang, Tyler Tomita, Joshua T. Vogelstein, Shibin Zhou, Nickolas Papadopoulos, Kenneth W. Kinzler, and Bert Vogelstein
  
  PNAS December 19, 2017 114 (51) 13519-13524; first published December 4, 2017. https://doi.org/10.1073/pnas.1712731114
- Open Access
  Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers
  Daniel Neiman, Joshua Moss, Merav Hecht, Judith Magenheim, Sheina Piyanzin, A. M. James Shapiro, Eelco J. P. de Koning, Aharon Razin, Howard Cedar, Ruth Shemer, and Yuval Dor
  
  PNAS December 19, 2017 114 (51) 13525-13530; first published December 4, 2017. https://doi.org/10.1073/pnas.1713736114
Microbiology
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  An endogenous retroviral envelope syncytin and its cognate receptor identified in the viviparous placental Mabuya lizard
  From the Cover
  
  Guillaume Cornelis, Mathis Funk, Cécile Vernochet, Francisca Leal, Oscar Alejandro Tarazona, Guillaume Meurice, Odile Heidmann, Anne Dupressoir, Aurélien Miralles, Martha Patricia Ramirez-Pinilla, and Thierry Heidmann
  
  PNAS December 19, 2017 114 (51) E10991-E11000; first published November 21, 2017. https://doi.org/10.1073/pnas.1714590114
  
  See companion article:
  Retroviruses, placenta, and lizards
  - Dec 07, 2017
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  Enigmatic origin of the poxvirus membrane from the endoplasmic reticulum shown by 3D imaging of vaccinia virus assembly mutants
  Andrea S. Weisberg, Liliana Maruri-Avidal, Himani Bisht, Bryan T. Hansen, Cindi L. Schwartz, Elizabeth R. Fischer, Xiangzhi Meng, Yan Xiang, and Bernard Moss
  
  PNAS December 19, 2017 114 (51) E11001-E11009; first published December 4, 2017. https://doi.org/10.1073/pnas.1716255114
- Open Access
  An inclusive Research Education Community (iREC): Impact of the SEA-PHAGES program on research outcomes and student learning
  David I. Hanauer, Mark J. Graham, SEA-PHAGES, Laura Betancur, Aiyana Bobrownicki, Steven G. Cresawn, Rebecca A. Garlena, Deborah Jacobs-Sera, Nancy Kaufmann, Welkin H. Pope, Daniel A. Russell, William R. Jacobs Jr., Viknesh Sivanathan, David J. Asai, and Graham F. Hatfull
  
  PNAS December 19, 2017 114 (51) 13531-13536; first published December 5, 2017. https://doi.org/10.1073/pnas.1718188115
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  MotI (DgrA) acts as a molecular clutch on the flagellar stator protein MotA in Bacillus subtilis
  Sundharraman Subramanian, Xiaohui Gao, Charles E. Dann III, and Daniel B. Kearns
  
  PNAS December 19, 2017 114 (51) 13537-13542; first published December 1, 2017. https://doi.org/10.1073/pnas.1716231114
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  Structural insights into the roles of the IcmS–IcmW complex in the type IVb secretion system of Legionella pneumophila
  Jianpo Xu, Dandan Xu, Muyang Wan, Li Yin, Xiaofei Wang, Lijie Wu, Yanhua Liu, Xiaoyun Liu, Yan Zhou, and Yongqun Zhu
  
  PNAS December 19, 2017 114 (51) 13543-13548; first published December 4, 2017. https://doi.org/10.1073/pnas.1706883115
Neuroscience
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  Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction
  Francesco Gianoli, Thomas Risler, and Andrei S. Kozlov
  
  PNAS December 19, 2017 114 (51) E11010-E11019; first published December 7, 2017. https://doi.org/10.1073/pnas.1713135114
- Open Access
  Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1
  D. Cristopher Bragg, Kotchaphorn Mangkalaphiban, Christine A. Vaine, Nichita J. Kulkarni, David Shin, Rachita Yadav, Jyotsna Dhakal, Mai-Linh Ton, Anne Cheng, Christopher T. Russo, Mark Ang, Patrick Acuña, Criscely Go, Taylor N. Francoeur, Trisha Multhaupt-Buell, Naoto Ito, Ulrich Müller, William T. Hendriks, Xandra O. Breakefield, Nutan Sharma, and Laurie J. Ozelius
  
  PNAS December 19, 2017 114 (51) E11020-E11028; first published December 11, 2017. https://doi.org/10.1073/pnas.1712526114
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  Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice
  Noah R. Johnson, Carlo Condello, Shenheng Guan, Abby Oehler, Julia Becker, Marta Gavidia, George A. Carlson, Kurt Giles, and Stanley B. Prusiner
  
  PNAS December 19, 2017 114 (51) E11029-E11036; first published December 4, 2017. https://doi.org/10.1073/pnas.1717193114
- Open Access
  Multiple oscillatory rhythms determine the temporal organization of perception
  Luca Ronconi, Nikolaas N. Oosterhof, Claudia Bonmassar, and David Melcher
  
  PNAS December 19, 2017 114 (51) 13435-13440; first published December 4, 2017. https://doi.org/10.1073/pnas.1714522114
- Open Access
  Early childhood stress exposure, reward pathways, and adult decision making
  Rasmus M. Birn, Barbara J. Roeber, and Seth D. Pollak
  
  PNAS December 19, 2017 114 (51) 13549-13554; first published December 4, 2017. https://doi.org/10.1073/pnas.1708791114
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  Contributions of primate prefrontal cortex and medial temporal lobe to temporal-order memory
  Yuji Naya, He Chen, Cen Yang, and Wendy A. Suzuki
  
  PNAS December 19, 2017 114 (51) 13555-13560; first published November 30, 2017. https://doi.org/10.1073/pnas.1712711114
Pharmacology
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  TRPV1 is a physiological regulator of μ-opioid receptors
  Paul C. Scherer, Nicholas W. Zaccor, Neil M. Neumann, Chirag Vasavda, Roxanne Barrow, Andrew J. Ewald, Feng Rao, Charlotte J. Sumner, and Solomon H. Snyder
  
  PNAS December 19, 2017 114 (51) 13561-13566; first published December 4, 2017. https://doi.org/10.1073/pnas.1717005114
Plant Biology
- Open Access
  Divergence of regulatory networks governed by the orthologous transcription factors FLC and PEP1 in Brassicaceae species
  Julieta L. Mateos, Vicky Tilmes, Pedro Madrigal, Edouard Severing, René Richter, Colin W. M. Rijkenberg, Paweł Krajewski, and George Coupland
  
  PNAS December 19, 2017 114 (51) E11037-E11046; first published December 4, 2017. https://doi.org/10.1073/pnas.1618075114
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  Efficient targeted DNA editing and replacement in Chlamydomonas reinhardtii using Cpf1 ribonucleoproteins and single-stranded DNA
  Aron Ferenczi, Douglas Euan Pyott, Andromachi Xipnitou, and Attila Molnar
  
  PNAS December 19, 2017 114 (51) 13567-13572; first published December 5, 2017. https://doi.org/10.1073/pnas.1710597114
Population Biology
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  Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity
  Sylvia L. Ranjeva, Edward B. Baskerville, Vanja Dukic, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano, Greg Dwyer, and Sarah Cobey
  
  PNAS December 19, 2017 114 (51) 13573-13578; first published December 5, 2017. https://doi.org/10.1073/pnas.1714712114
Psychological and Cognitive Sciences
- Open Access
  Encoding model of temporal processing in human visual cortex
  Anthony Stigliani, Brianna Jeska, and Kalanit Grill-Spector
  
  PNAS December 19, 2017 114 (51) E11047-E11056; first published December 5, 2017. https://doi.org/10.1073/pnas.1704877114
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  Musical training sharpens and bonds ears and tongue to hear speech better
  Yi Du and Robert J. Zatorre
  
  PNAS December 19, 2017 114 (51) 13579-13584; first published December 4, 2017. https://doi.org/10.1073/pnas.1712223114

Corrections (Online Only)

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Correction for Kang et al., Increased intracellular Ca²⁺ concentrations prevent membrane localization of PH domains through the formation of Ca²⁺-phosphoinositides
PNAS December 19, 2017 114 (51) E11057; first published November 27, 2017. https://doi.org/10.1073/pnas.1719887115
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Correction for Matthews et al., Optimal nutrient exchange and immune responses operate in partner specificity in the cnidarian-dinoflagellate symbiosis
PNAS December 19, 2017 114 (51) E11058; first published December 11, 2017. https://doi.org/10.1073/pnas.1720356115
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Correction for Giang et al., Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
PNAS December 19, 2017 114 (51) E11059; first published December 11, 2017. https://doi.org/10.1073/pnas.1720228115
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Correction for Gerth et al., Intersectin associates with synapsin and regulates its nanoscale localization and function
PNAS December 19, 2017 114 (51) E11060; first published December 11, 2017. https://doi.org/10.1073/pnas.1720226115

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