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Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity
Edited by Burton H. Singer, University of Florida, Gainesville, FL, and approved November 10, 2017 (received for review August 23, 2017)

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Article Information
- Published in issue December 19, 2017.
- Published first December 5, 2017.
Article Versions
- Previous version (December 5, 2017 - 09:02).
- You are viewing the most recent version of this article.
Author Information
- Sylvia L. Ranjevaa,1,
- Edward B. Baskervillea,
- Vanja Dukicb,
- Luisa L. Villac,
- Eduardo Lazcano-Ponced,
- Anna R. Giulianoe,
- Greg Dwyera, and
- Sarah Cobeya
- aDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
- bDepartment of Applied Mathematics, University of Colorado, Boulder, CO 80309;
- cFaculdade de Medicina, Universidade de São Paulo Department of Radiology and Oncology, Centro de Investigação Translacional em Oncologia, Universidade de São Paulo, 01246-000, São Paulo, Brazil;
- dCentro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, 62100, Mexico;
- eCenter for Infection Research in Cancer, Moffitt Cancer Center & Research Institute, Tampa, FL 33612
Edited by Burton H. Singer, University of Florida, Gainesville, FL, and approved November 10, 2017 (received for review August 23, 2017)
Footnotes
- ↵1To whom correspondence should be addressed. Email: slr{at}uchicago.edu.
Author contributions: S.L.R., G.D., and S.C. designed research; S.L.R., L.L.V., E.L.-P., and A.R.G. performed research; E.B.B. and V.D. contributed new reagents/analytic tools; S.L.R. analyzed data; V.D. provided statistical expertise for the mathematical models; L.L.V., E.L.-P., and A.R.G. contributed the clinical data; A.R.G. provided epidemiological expertise to the analysis; and S.L.R., G.D., and S.C. wrote the paper.
Conflict of interest statement: L.L.V. is a consultant and member of the board of Merck, Sharp & Dohme for the HPV prophylactic vaccine. The institution of A.R.G. has received and currently receives grant funds on her behalf from Merck & Co for investigator-initiated research. A.R.G. also serves on the Scientific and Advisory Boards for Merck & Co. Neither of these relate to the submitted work. All other authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1714712114/-/DCSupplemental.
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