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Research Article

Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity

Sylvia L. Ranjeva, View ORCID ProfileEdward B. Baskerville, Vanja Dukic, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano, Greg Dwyer, and Sarah Cobey
PNAS December 19, 2017 114 (51) 13573-13578; first published December 5, 2017; https://doi.org/10.1073/pnas.1714712114
Sylvia L. Ranjeva
aDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
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  • For correspondence: slr@uchicago.edu
Edward B. Baskerville
aDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
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  • ORCID record for Edward B. Baskerville
Vanja Dukic
bDepartment of Applied Mathematics, University of Colorado, Boulder, CO 80309;
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Luisa L. Villa
cFaculdade de Medicina, Universidade de São Paulo Department of Radiology and Oncology, Centro de Investigação Translacional em Oncologia, Universidade de São Paulo, 01246-000, São Paulo, Brazil;
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Eduardo Lazcano-Ponce
dCentro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, 62100, Mexico;
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Anna R. Giuliano
eCenter for Infection Research in Cancer, Moffitt Cancer Center & Research Institute, Tampa, FL 33612
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Greg Dwyer
aDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
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Sarah Cobey
aDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
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  1. Edited by Burton H. Singer, University of Florida, Gainesville, FL, and approved November 10, 2017 (received for review August 23, 2017)

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Article Information

vol. 114 no. 51 13573-13578
DOI: 
https://doi.org/10.1073/pnas.1714712114
PubMed: 
29208707

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue December 19, 2017.
  • Published first December 5, 2017.

Article Versions

  • Previous version (December 5, 2017 - 09:02).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2017 Published under the PNAS license.

Author Information

  1. Sylvia L. Ranjevaa,1,
  2. Edward B. Baskervillea,
  3. Vanja Dukicb,
  4. Luisa L. Villac,
  5. Eduardo Lazcano-Ponced,
  6. Anna R. Giulianoe,
  7. Greg Dwyera, and
  8. Sarah Cobeya
  1. aDepartment of Ecology and Evolution, University of Chicago, Chicago, IL 60637;
  2. bDepartment of Applied Mathematics, University of Colorado, Boulder, CO 80309;
  3. cFaculdade de Medicina, Universidade de São Paulo Department of Radiology and Oncology, Centro de Investigação Translacional em Oncologia, Universidade de São Paulo, 01246-000, São Paulo, Brazil;
  4. dCentro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, 62100, Mexico;
  5. eCenter for Infection Research in Cancer, Moffitt Cancer Center & Research Institute, Tampa, FL 33612
  1. Edited by Burton H. Singer, University of Florida, Gainesville, FL, and approved November 10, 2017 (received for review August 23, 2017)

Footnotes

  • ↵1To whom correspondence should be addressed. Email: slr{at}uchicago.edu.
  • Author contributions: S.L.R., G.D., and S.C. designed research; S.L.R., L.L.V., E.L.-P., and A.R.G. performed research; E.B.B. and V.D. contributed new reagents/analytic tools; S.L.R. analyzed data; V.D. provided statistical expertise for the mathematical models; L.L.V., E.L.-P., and A.R.G. contributed the clinical data; A.R.G. provided epidemiological expertise to the analysis; and S.L.R., G.D., and S.C. wrote the paper.

  • Conflict of interest statement: L.L.V. is a consultant and member of the board of Merck, Sharp & Dohme for the HPV prophylactic vaccine. The institution of A.R.G. has received and currently receives grant funds on her behalf from Merck & Co for investigator-initiated research. A.R.G. also serves on the Scientific and Advisory Boards for Merck & Co. Neither of these relate to the submitted work. All other authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1714712114/-/DCSupplemental.

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Article usage

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AbstractFullPdf
Dec 20175762320174
Total 20175762320174
Jan 201822807868
Feb 20188835428
Mar 20184915723
Apr 20186395122
May 201814885527
Jun 201854329434
Jul 201839645226
Aug 201838745147
Sep 201839545434
Oct 20184242946
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Dec 2018747428
Total 201875673273435
Jan 20192770943
Feb 20191636231
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Apr 20191937049
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Jun 20191123929
Jul 2019728536
Aug 2019839143
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Total 20191493985462
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Feb 20201734430
Mar 20201019632
Apr 2020820935
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Jul 2020520921
Aug 2020532823
Sep 20201228324
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Total 20201743761343
Jan 202131298
Total 202131298
Total13655114681422
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High HPV prevalence arises by recurring infection
Sylvia L. Ranjeva, Edward B. Baskerville, Vanja Dukic, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano, Greg Dwyer, Sarah Cobey
Proceedings of the National Academy of Sciences Dec 2017, 114 (51) 13573-13578; DOI: 10.1073/pnas.1714712114

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High HPV prevalence arises by recurring infection
Sylvia L. Ranjeva, Edward B. Baskerville, Vanja Dukic, Luisa L. Villa, Eduardo Lazcano-Ponce, Anna R. Giuliano, Greg Dwyer, Sarah Cobey
Proceedings of the National Academy of Sciences Dec 2017, 114 (51) 13573-13578; DOI: 10.1073/pnas.1714712114
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