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Table of Contents

December 26, 2017; vol. 114 no. 52

This Week in PNAS

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    In This Issue
    PNAS December 26, 2017 114 (52) 13585-13586; https://doi.org/10.1073/iti5217114

Reviewer Acknowledgment (Online Only)

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    Acknowledgment of Reviewers, 2017
    PNAS December 26, 2017 114 (52) E11337-E11375; https://doi.org/10.1073/pnas.reviewers114

Letter (Online Only)

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    Intercellular competition and levels of development: The plasticity of inevitability
    Robert B. Eckhardt, Alex S. Weller, and Maciej Henneberg
    PNAS December 26, 2017 114 (52) E11061-E11062; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1719479115

Opinion

Leading scientists discuss current issues.
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    Opinion: Why we need a National Living Soil Repository
    • Front Matter
    Daniel K. Manter, Jorge A. Delgado, Harvey D. Blackburn, Daren Harmel, Adalberto A. Pérez de León, and C. Wayne Honeycutt
    PNAS December 26, 2017 114 (52) 13587-13590; https://doi.org/10.1073/pnas.1720262115

Commentaries

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    NO and COX2: Dual targeting for aggressive cancers
    Daniel Davila-Gonzalez, Jenny C. Chang, and Timothy R. Billiar
    PNAS December 26, 2017 114 (52) 13591-13593; published ahead of print December 13, 2017. https://doi.org/10.1073/pnas.1717440114
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    Photochemistry of highly excited states
    R. D. Levine
    PNAS December 26, 2017 114 (52) 13594-13596; published ahead of print November 30, 2017. https://doi.org/10.1073/pnas.1718814114
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    Dopamine prediction error responses update demand
    Kathryn M. Rothenhoefer and William R. Stauffer
    PNAS December 26, 2017 114 (52) 13597-13599; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1718818115
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    The hydraulic lift of early states societies
    Vernon L. Scarborough
    PNAS December 26, 2017 114 (52) 13600-13601; published ahead of print December 13, 2017. https://doi.org/10.1073/pnas.1719536115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS December 26, 2017 114 (52) 13602-13606; https://doi.org/10.1073/pnas.ss11452

Physical Sciences

  • Applied Physical Sciences

    • Open Access
      Making two-photon processes dominate one-photon processes using mid-IR phonon polaritons
      Nicholas Rivera, Gilles Rosolen, John D. Joannopoulos, Ido Kaminer, and Marin Soljačić
      PNAS December 26, 2017 114 (52) 13607-13612; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1713538114
  • Biophysics and Computational Biology

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      How reduced excitonic coupling enhances light harvesting in the main photosynthetic antennae of diatoms
      Tjaart P. J. Krüger, Pavel Malý, Maxime T. A. Alexandre, Tomáš Mančal, Claudia Büchel, and Rienk van Grondelle
      PNAS December 26, 2017 114 (52) E11063-E11071; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714656115
  • Chemistry

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      Ultrafast 25-fs relaxation in highly excited states of methyl azide mediated by strong nonadiabatic coupling
      • From the Cover
      William K. Peters, David E. Couch, Benoit Mignolet, Xuetao Shi, Quynh L. Nguyen, Ryan C. Fortenberry, H. Bernhard Schlegel, Françoise Remacle, Henry C. Kapteyn, Margaret M. Murnane, and Wen Li
      PNAS December 26, 2017 114 (52) E11072-E11081; published ahead of print November 6, 2017. https://doi.org/10.1073/pnas.1712566114
    • You have access
      Designing flexible 2D transition metal carbides with strain-controllable lithium storage
      Hang Zhang, Zhongheng Fu, Ruifeng Zhang, Qianfan Zhang, Hongzhen Tian, Dominik Legut, Timothy C. Germann, Yuanqi Guo, Shiyu Du, and Joseph S. Francisco
      PNAS December 26, 2017 114 (52) E11082-E11091; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1717219115
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      Ultrafast rotation in an amphidynamic crystalline metal organic framework
      Cortnie S. Vogelsberg, Fernando J. Uribe-Romo, Andrew S. Lipton, Song Yang, K. N. Houk, Stuart Brown, and Miguel A. Garcia-Garibay
      PNAS December 26, 2017 114 (52) 13613-13618; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1708817115
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      Autocatalytic surface reduction and its role in controlling seed-mediated growth of colloidal metal nanocrystals
      Tung-Han Yang, Shan Zhou, Kyle D. Gilroy, Legna Figueroa-Cosme, Yi-Hsien Lee, Jenn-Ming Wu, and Younan Xia
      PNAS December 26, 2017 114 (52) 13619-13624; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713907114
    • Open Access
      SE2 reaction in noncarbon system: Metal-halide catalysis for dehydrogenation of ammonia borane
      Sung Jin Pai and Sang Soo Han
      PNAS December 26, 2017 114 (52) 13625-13630; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1712137115
    • You have access
      Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation
      Rongfeng Zhu, Yanqun Song, Haiping Liu, Yufei Yang, Shenlin Wang, Chengqi Yi, and Peng R. Chen
      PNAS December 26, 2017 114 (52) 13661-13666; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1708563115
  • Earth, Atmospheric, and Planetary Sciences

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      Global biogeochemical cycle of vanadium
      William H. Schlesinger, Emily M. Klein, and Avner Vengosh
      PNAS December 26, 2017 114 (52) E11092-E11100; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1715500114
  • Engineering

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      Understanding the mechanisms of amorphous creep through molecular simulation
      Penghui Cao, Michael P. Short, and Sidney Yip
      PNAS December 26, 2017 114 (52) 13631-13636; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1708618114
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      Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance
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      PNAS December 26, 2017 114 (52) 13679-13684; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1712064115
  • Environmental Sciences

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      Earliest hydraulic enterprise in China, 5,100 years ago
      • From the Cover
      Bin Liu, Ningyuan Wang, Minghui Chen, Xiaohong Wu, Duowen Mo, Jianguo Liu, Shijin Xu, and Yijie Zhuang
      PNAS December 26, 2017 114 (52) 13637-13642; published ahead of print December 4, 2017. https://doi.org/10.1073/pnas.1710516114

Social Sciences

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    • Open Access
      Population is the main driver of war group size and conflict casualties
      Rahul C. Oka, Marc Kissel, Mark Golitko, Susan Guise Sheridan, Nam C. Kim, and Agustín Fuentes
      PNAS December 26, 2017 114 (52) E11101-E11110; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713972114
    • You have access
      Earliest hydraulic enterprise in China, 5,100 years ago
      • From the Cover
      Bin Liu, Ningyuan Wang, Minghui Chen, Xiaohong Wu, Duowen Mo, Jianguo Liu, Shijin Xu, and Yijie Zhuang
      PNAS December 26, 2017 114 (52) 13637-13642; published ahead of print December 4, 2017. https://doi.org/10.1073/pnas.1710516114
  • Psychological and Cognitive Sciences

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      Default neglect in attempts at social influence
      Julian J. Zlatev, David P. Daniels, Hajin Kim, and Margaret A. Neale
      PNAS December 26, 2017 114 (52) 13643-13648; published ahead of print December 8, 2017. https://doi.org/10.1073/pnas.1712757114

Biological Sciences

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      Population is the main driver of war group size and conflict casualties
      Rahul C. Oka, Marc Kissel, Mark Golitko, Susan Guise Sheridan, Nam C. Kim, and Agustín Fuentes
      PNAS December 26, 2017 114 (52) E11101-E11110; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713972114
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      Sex determination of human remains from peptides in tooth enamel
      Nicolas Andre Stewart, Raquel Fernanda Gerlach, Rebecca L. Gowland, Kurt J. Gron, and Janet Montgomery
      PNAS December 26, 2017 114 (52) 13649-13654; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714926115
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      Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs
      Ming-Tao Zhao, Haodong Chen, Qing Liu, Ning-Yi Shao, Nazish Sayed, Hung-Ta Wo, Joe Z. Zhang, Sang-Ging Ong, Chun Liu, Youngkyun Kim, Huaxiao Yang, Tony Chour, Hong Ma, Nuria Marti Gutierrez, Ioannis Karakikes, Shoukhrat Mitalipov, Michael P. Snyder, and Joseph C. Wu
      PNAS December 26, 2017 114 (52) E11111-E11120; published ahead of print December 4, 2017. https://doi.org/10.1073/pnas.1708991114
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      PSMA-targeted polyinosine/polycytosine vector induces prostate tumor regression and invokes an antitumor immune response in mice
      Yael Langut, Alaa Talhami, Samarasimhareddy Mamidi, Alexei Shir, Maya Zigler, Salim Joubran, Anna Sagalov, Efrat Flashner-Abramson, Nufar Edinger, Shoshana Klein, and Alexander Levitzki
      PNAS December 26, 2017 114 (52) 13655-13660; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714587115
  • Biochemistry

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      Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality
      Gregory C. A. Amos, Takayoshi Awakawa, Robert N. Tuttle, Anne-Catrin Letzel, Min Cheol Kim, Yuta Kudo, William Fenical, Bradley S. Moore, and Paul R. Jensen
      PNAS December 26, 2017 114 (52) E11121-E11130; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714381115
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      Discovery of the leinamycin family of natural products by mining actinobacterial genomes
      Guohui Pan, Zhengren Xu, Zhikai Guo, Hindra, Ming Ma, Dong Yang, Hao Zhou, Yannick Gansemans, Xiangcheng Zhu, Yong Huang, Li-Xing Zhao, Yi Jiang, Jinhua Cheng, Filip Van Nieuwerburgh, Joo-Won Suh, Yanwen Duan, and Ben Shen
      PNAS December 26, 2017 114 (52) E11131-E11140; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716245115
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      Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
      Benjamin R. Myers, Lila Neahring, Yunxiao Zhang, Kelsey J. Roberts, and Philip A. Beachy
      PNAS December 26, 2017 114 (52) E11141-E11150; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1717891115
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      Allosteric histidine switch for regulation of intracellular zinc(II) fluctuation
      Rongfeng Zhu, Yanqun Song, Haiping Liu, Yufei Yang, Shenlin Wang, Chengqi Yi, and Peng R. Chen
      PNAS December 26, 2017 114 (52) 13661-13666; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1708563115
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      Distinct roles of N- and O-glycans in cellulase activity and stability
      Antonella Amore, Brandon C. Knott, Nitin T. Supekar, Asif Shajahan, Parastoo Azadi, Peng Zhao, Lance Wells, Jeffrey G. Linger, Sarah E. Hobdey, Todd A. Vander Wall, Todd Shollenberger, John M. Yarbrough, Zhongping Tan, Michael F. Crowley, Michael E. Himmel, Stephen R. Decker, Gregg T. Beckham, and Larry E. Taylor II
      PNAS December 26, 2017 114 (52) 13667-13672; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714249114
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      Kinetics of drug–ribosome interactions defines the cidality of macrolide antibiotics
      Maxim S. Svetlov, Nora Vázquez-Laslop, and Alexander S. Mankin
      PNAS December 26, 2017 114 (52) 13673-13678; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1717168115
  • Biophysics and Computational Biology

    • Open Access
      Molecular mechanism for the subversion of the retromer coat by the Legionella effector RidL
      Miguel Romano-Moreno, Adriana L. Rojas, Chad D. Williamson, David C. Gershlick, María Lucas, Michail N. Isupov, Juan S. Bonifacino, Matthias P. Machner, and Aitor Hierro
      PNAS December 26, 2017 114 (52) E11151-E11160; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1715361115
    • You have access
      Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance
      Yapeng Su, Wei Wei, Lidia Robert, Min Xue, Jennifer Tsoi, Angel Garcia-Diaz, Blanca Homet Moreno, Jungwoo Kim, Rachel H. Ng, Jihoon W. Lee, Richard C. Koya, Begonya Comin-Anduix, Thomas G. Graeber, Antoni Ribas, and James R. Heath
      PNAS December 26, 2017 114 (52) 13679-13684; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1712064115
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      Structure-based prediction of ligand–protein interactions on a genome-wide scale
      Howook Hwang, Fabian Dey, Donald Petrey, and Barry Honig
      PNAS December 26, 2017 114 (52) 13685-13690; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1705381114
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      Three tRNAs on the ribosome slow translation elongation
      Junhong Choi and Joseph D. Puglisi
      PNAS December 26, 2017 114 (52) 13691-13696; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1719592115
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      Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth
      Adam R. Griffith, Claude J. Rogers, Gregory M. Miller, Ravinder Abrol, Linda C. Hsieh-Wilson, and William A. Goddard III
      PNAS December 26, 2017 114 (52) 13697-13702; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1715093115
    • You have access
      Structural studies of Chikungunya virus maturation
      • From the Cover
      Moh Lan Yap, Thomas Klose, Akane Urakami, S. Saif Hasan, Wataru Akahata, and Michael G. Rossmann
      PNAS December 26, 2017 114 (52) 13703-13707; published ahead of print December 4, 2017. https://doi.org/10.1073/pnas.1713166114
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      Structural changes of tailless bacteriophage ΦX174 during penetration of bacterial cell walls
      Yingyuan Sun, Aaron P. Roznowski, Joshua M. Tokuda, Thomas Klose, Alexander Mauney, Lois Pollack, Bentley A. Fane, and Michael G. Rossmann
      PNAS December 26, 2017 114 (52) 13708-13713; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716614114
    • Open Access
      Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription
      Anastasiya Belyaeva, Saradha Venkatachalapathy, Mallika Nagarajan, G. V. Shivashankar, and Caroline Uhler
      PNAS December 26, 2017 114 (52) 13714-13719; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1708028115
  • Cell Biology

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      Cytoplasmic Cl− couples membrane remodeling to epithelial morphogenesis
      Mu He, Wenlei Ye, Won-Jing Wang, Eirish S. Sison, Yuh Nung Jan, and Lily Yeh Jan
      PNAS December 26, 2017 114 (52) E11161-E11169; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714448115
    • Open Access
      Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles
      Kimberly Siletti, Basile Tarchini, and A. J. Hudspeth
      PNAS December 26, 2017 114 (52) E11170-E11179; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716522115
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      Architecture of the human PI4KIIIα lipid kinase complex
      Joshua A. Lees, Yixiao Zhang, Michael S. Oh, Curtis M. Schauder, Xiaoling Yu, Jeremy M. Baskin, Kerry Dobbs, Luigi D. Notarangelo, Pietro De Camilli, Thomas Walz, and Karin M. Reinisch
      PNAS December 26, 2017 114 (52) 13720-13725; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1718471115
    • Open Access
      Proteasomes tether to two distinct sites at the nuclear pore complex
      Sahradha Albert, Miroslava Schaffer, Florian Beck, Shyamal Mosalaganti, Shoh Asano, Henry F. Thomas, Jürgen M. Plitzko, Martin Beck, Wolfgang Baumeister, and Benjamin D. Engel
      PNAS December 26, 2017 114 (52) 13726-13731; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716305114
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      O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect
      Yang Wang, Jia Liu, Xin Jin, Dapeng Zhang, Dongxue Li, Fengqi Hao, Yunpeng Feng, Shan Gu, Fanlin Meng, Miaomiao Tian, Yi Zheng, Ling Xin, Xinbo Zhang, Xue Han, L. Aravind, and Min Wei
      PNAS December 26, 2017 114 (52) 13732-13737; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1704145115
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      A small-molecule activator of kinesin-1 drives remodeling of the microtubule network
      • From the Cover
      Thomas S. Randall, Yan Y. Yip, Daynea J. Wallock-Richards, Karin Pfisterer, Anneri Sanger, Weronika Ficek, Roberto A. Steiner, Andrew J. Beavil, Maddy Parsons, and Mark P. Dodding
      PNAS December 26, 2017 114 (52) 13738-13743; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1715115115
  • Developmental Biology

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      Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development
      Kesavan Meganathan, Emily M. A. Lewis, Paul Gontarz, Shaopeng Liu, Edouard G. Stanley, Andrew G. Elefanty, James E. Huettner, Bo Zhang, and Kristen L. Kroll
      PNAS December 26, 2017 114 (52) E11180-E11189; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1712365115
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      Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney
      Frans Schutgens, Maarten B. Rookmaaker, Francis Blokzijl, Ruben van Boxtel, Robert Vries, Edwin Cuppen, Marianne C. Verhaar, and Hans Clevers
      PNAS December 26, 2017 114 (52) E11190-E11198; published ahead of print December 13, 2017. https://doi.org/10.1073/pnas.1714145115
    • Open Access
      Machine learning shows association between genetic variability in PPARG and cerebral connectivity in preterm infants
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      PNAS December 26, 2017 114 (52) 13744-13749; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1704907114
  • Ecology

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      Zooplankton can actively adjust their motility to turbulent flow
      François-Gaël Michalec, Itzhak Fouxon, Sami Souissi, and Markus Holzner
      PNAS December 26, 2017 114 (52) E11199-E11207; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1708888114
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      Human presence diminishes the importance of climate in driving fire activity across the United States
      Alexandra D. Syphard, Jon E. Keeley, Anne H. Pfaff, and Ken Ferschweiler
      PNAS December 26, 2017 114 (52) 13750-13755; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713885114
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      Naturalization of European plants on other continents: The role of donor habitats
      Veronika Kalusová, Milan Chytrý, Mark van Kleunen, Ladislav Mucina, Wayne Dawson, Franz Essl, Holger Kreft, Jan Pergl, Patrick Weigelt, Marten Winter, and Petr Pyšek
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    • Open Access
      Critical dynamics in population vaccinating behavior
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      PNAS December 26, 2017 114 (52) 13762-13767; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1704093114
  • Evolution

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      Dispersal limitation promotes the diversification of the mammalian gut microbiota
      Andrew H. Moeller, Taichi A. Suzuki, Dana Lin, Eileen A. Lacey, Samuel K. Wasser, and Michael W. Nachman
      PNAS December 26, 2017 114 (52) 13768-13773; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1700122114
    • Open Access
      Resource limitation prevents the emergence of drug resistance by intensifying within-host competition
      Nina Wale, Derek G. Sim, Matthew J. Jones, Rahel Salathe, Troy Day, and Andrew F. Read
      PNAS December 26, 2017 114 (52) 13774-13779; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1715874115
  • Genetics

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      Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi
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      Effects of mutation and selection on plasticity of a promoter activity in Saccharomyces cerevisiae
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      PNAS December 26, 2017 114 (52) E11218-E11227; published ahead of print December 19, 2017. https://doi.org/10.1073/pnas.1713960115
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      Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans
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      ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+ T cell pathogenicity during CNS inflammation
      Christian W. Keller, Christina Sina, Monika B. Kotur, Giulia Ramelli, Sarah Mundt, Isaak Quast, Laure-Anne Ligeon, Patrick Weber, Burkhard Becher, Christian Münz, and Jan D. Lünemann
      PNAS December 26, 2017 114 (52) E11228-E11237; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1713664114
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      Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress
      Eui Jae Sung, Masasuke Ryuda, Hitoshi Matsumoto, Outa Uryu, Masanori Ochiai, Molly E. Cook, Na Young Yi, Huanchen Wang, James W. Putney, Gary S. Bird, Stephen B. Shears, and Yoichi Hayakawa
      PNAS December 26, 2017 114 (52) 13786-13791; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1712453115
  • Medical Sciences

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      Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes
      Soohyun P. Kim, Julie L. Frey, Zhu Li, Priyanka Kushwaha, Meredith L. Zoch, Ryan E. Tomlinson, Hao Da, Susan Aja, Hye Lim Noh, Jason K. Kim, Mehboob A. Hussain, Daniel L. J. Thorek, Michael J. Wolfgang, and Ryan C. Riddle
      PNAS December 26, 2017 114 (52) E11238-E11247; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1707876115
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      Clinical, genetic, and structural basis of apparent mineralocorticoid excess due to 11β-hydroxysteroid dehydrogenase type 2 deficiency
      Mabel Yau, Shozeb Haider, Ahmed Khattab, Chen Ling, Mehr Mathew, Samir Zaidi, Madison Bloch, Monica Patel, Sinead Ewert, Wafa Abdullah, Aysenur Toygar, Vitalii Mudryi, Maryam Al Badi, Mouch Alzubdi, Robert C. Wilson, Hanan Said Al Azkawi, Hatice Nur Ozdemir, Wahid Abu-Amer, Jozef Hertecant, Maryam Razzaghy-Azar, John W. Funder, Aisha Al Senani, Li Sun, Se-Min Kim, Tony Yuen, Mone Zaidi, and Maria I. New
      PNAS December 26, 2017 114 (52) E11248-E11256; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716621115
    • Open Access
      Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci
      Samuel Lessard, Laurent Francioli, Jessica Alfoldi, Jean-Claude Tardif, Patrick T. Ellinor, Daniel G. MacArthur, Guillaume Lettre, Stuart H. Orkin, and Matthew C. Canver
      PNAS December 26, 2017 114 (52) E11257-E11266; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714640114
    • Open Access
      Impact of insecticide resistance in Anopheles arabiensis on malaria incidence and prevalence in Sudan and the costs of mitigation
      Hmooda Toto Kafy, Bashir Adam Ismail, Abraham Peter Mnzava, Jonathan Lines, Mogahid Shiekh Eldin Abdin, Jihad Sulieman Eltaher, Anuar Osman Banaga, Philippa West, John Bradley, Jackie Cook, Brent Thomas, Krishanthi Subramaniam, Janet Hemingway, Tessa Bellamy Knox, Elfatih M. Malik, Joshua O. Yukich, Martin James Donnelly, and Immo Kleinschmidt
      PNAS December 26, 2017 114 (52) E11267-E11275; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713814114
    • Open Access
      Identification of cancer genes that are independent of dominant proliferation and lineage programs
      Laura M. Selfors, Daniel G. Stover, Isaac S. Harris, Joan S. Brugge, and Jonathan L. Coloff
      PNAS December 26, 2017 114 (52) E11276-E11284; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714877115
    • Open Access
      Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice
      João Paulo Camporez, Yongliang Wang, Kasper Faarkrog, Natsasi Chukijrungroat, Kitt Falk Petersen, and Gerald I. Shulman
      PNAS December 26, 2017 114 (52) E11285-E11292; published ahead of print December 13, 2017. https://doi.org/10.1073/pnas.1716990115
    • Open Access
      Interferon-beta represses cancer stem cell properties in triple-negative breast cancer
      Mary R. Doherty, HyeonJoo Cheon, Damian J. Junk, Shaveta Vinayak, Vinay Varadan, Melinda L. Telli, James M. Ford, George R. Stark, and Mark W. Jackson
      PNAS December 26, 2017 114 (52) 13792-13797; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713728114
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      Early endosome as a pathogenic target for antiphosphatidylethanolamine antibodies
      Songwang Hou, Heike Fölsch, Ke Ke, Joan Cook Mills, Rosalind Ramsey-Goldman, and Ming Zhao
      PNAS December 26, 2017 114 (52) 13798-13803; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714027115
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      Obligatory role of hypothalamic neuroestradiol during the estrogen-induced LH surge in female ovariectomized rhesus monkeys
      Brian P. Kenealy, Kim L. Keen, James P. Garcia, Lucille K. Kohlenberg, and Ei Terasawa
      PNAS December 26, 2017 114 (52) 13804-13809; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716097115
  • Neuroscience

    • Open Access
      Brain urea increase is an early Huntington’s disease pathogenic event observed in a prodromal transgenic sheep model and HD cases
      Renee R. Handley, Suzanne J. Reid, Rudiger Brauning, Paul Maclean, Emily R. Mears, Imche Fourie, Stefano Patassini, Garth J. S. Cooper, Skye R. Rudiger, Clive J. McLaughlan, Paul J. Verma, James F. Gusella, Marcy E. MacDonald, Henry J. Waldvogel, C. Simon Bawden, Richard L. M. Faull, and Russell G. Snell
      PNAS December 26, 2017 114 (52) E11293-E11302; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1711243115
    • Open Access
      A transient dopamine signal encodes subjective value and causally influences demand in an economic context
      • From the Cover
      Scott A. Schelp, Katherine J. Pultorak, Dylan R. Rakowski, Devan M. Gomez, Gregory Krzystyniak, Raibatak Das, and Erik B. Oleson
      PNAS December 26, 2017 114 (52) E11303-E11312; published ahead of print November 6, 2017. https://doi.org/10.1073/pnas.1706969114
    • Open Access
      FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome
      Gabriela Caraveo, Martin Soste, Valentina Cappelleti, Saranna Fanning, Damian B. van Rossum, Luke Whitesell, Yanmei Huang, Chee Yeun Chung, Valeriya Baru, Sofia Zaichick, Paola Picotti, and Susan Lindquist
      PNAS December 26, 2017 114 (52) E11313-E11322; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1711926115
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      Beta oscillations reflect supramodal information during perceptual judgment
      Saskia Haegens, José Vergara, Román Rossi-Pool, Luis Lemus, and Ranulfo Romo
      PNAS December 26, 2017 114 (52) 13810-13815; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714633115
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      Appetite suppressive role of medial septal glutamatergic neurons
      Patrick Sweeney, Changhong Li, and Yunlei Yang
      PNAS December 26, 2017 114 (52) 13816-13821; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1707228114
  • Physiology

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      Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo
      G. Sebastian Hönes, Helena Rakov, John Logan, Xiao-Hui Liao, Eugenie Werbenko, Andrea S. Pollard, Stine M. Præstholm, Majken S. Siersbæk, Eddy Rijntjes, Janina Gassen, Sören Latteyer, Kathrin Engels, Karl-Heinz Strucksberg, Petra Kleinbongard, Denise Zwanziger, Jan Rozman, Valerie Gailus-Durner, Helmut Fuchs, Martin Hrabe de Angelis, Ludger Klein-Hitpass, Josef Köhrle, David L. Armstrong, Lars Grøntved, J. H. Duncan Bassett, Graham R. Williams, Samuel Refetoff, Dagmar Führer, and Lars C. Moeller
      PNAS December 26, 2017 114 (52) E11323-E11332; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1706801115
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      De novo reconstitution reveals the proteins required for skeletal muscle voltage-induced Ca2+ release
      Stefano Perni, Manuela Lavorato, and Kurt G. Beam
      PNAS December 26, 2017 114 (52) 13822-13827; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1716461115
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      Accelerating fishes increase propulsive efficiency by modulating vortex ring geometry
      Otar Akanyeti, Joy Putney, Yuzo R. Yanagitsuru, George V. Lauder, William J. Stewart, and James C. Liao
      PNAS December 26, 2017 114 (52) 13828-13833; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1705968115
  • Plant Biology

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      How reduced excitonic coupling enhances light harvesting in the main photosynthetic antennae of diatoms
      Tjaart P. J. Krüger, Pavel Malý, Maxime T. A. Alexandre, Tomáš Mančal, Claudia Büchel, and Rienk van Grondelle
      PNAS December 26, 2017 114 (52) E11063-E11071; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1714656115
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      Ethylene promotes root hair growth through coordinated EIN3/EIL1 and RHD6/RSL1 activity in Arabidopsis
      Ying Feng, Ping Xu, Bosheng Li, Pengpeng Li, Xing Wen, Fengying An, Yan Gong, Yi Xin, Ziqiang Zhu, Yichuan Wang, and Hongwei Guo
      PNAS December 26, 2017 114 (52) 13834-13839; published ahead of print December 12, 2017. https://doi.org/10.1073/pnas.1711723115
  • Psychological and Cognitive Sciences

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      Perception and misperception of surface opacity
      Phillip J. Marlow, Juno Kim, and Barton L. Anderson
      PNAS December 26, 2017 114 (52) 13840-13845; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1711416115
  • Sustainability Science

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      Human presence diminishes the importance of climate in driving fire activity across the United States
      Alexandra D. Syphard, Jon E. Keeley, Anne H. Pfaff, and Ken Ferschweiler
      PNAS December 26, 2017 114 (52) 13750-13755; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1713885114

Corrections (Online Only)

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    Correction for Waldrop, News Feature: The genuine problem of fake news
    PNAS December 26, 2017 114 (52) E11333; published ahead of print December 18, 2017. https://doi.org/10.1073/pnas.1721073115
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    Correction for Roehr, Core Concept: Tissue resident memory cells emerging as key player in health and disease
    PNAS December 26, 2017 114 (52) E11334; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1720330115
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    Correction for Possner and Caldeira, Geophysical potential for wind energy over the open oceans
    PNAS December 26, 2017 114 (52) E11335; published ahead of print December 11, 2017. https://doi.org/10.1073/pnas.1720315115

Retraction (Online Only)

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    Retraction for Ottmann et al., Long-term aggregation of larval fish siblings during dispersal along an open coast
    PNAS December 26, 2017 114 (52) E11336; published ahead of print December 18, 2017. https://doi.org/10.1073/pnas.1720656115
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Proceedings of the National Academy of Sciences: 114 (52)
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