Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology
Research Article

Rare variants in axonogenesis genes connect three families with sound–color synesthesia

View ORCID ProfileAmanda K. Tilot, Katerina S. Kucera, Arianna Vino, Julian E. Asher, Simon Baron-Cohen, and View ORCID ProfileSimon E. Fisher
PNAS March 20, 2018 115 (12) 3168-3173; first published March 5, 2018; https://doi.org/10.1073/pnas.1715492115
Amanda K. Tilot
aLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Amanda K. Tilot
Katerina S. Kucera
aLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arianna Vino
aLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julian E. Asher
bAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, United Kingdom;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon Baron-Cohen
bAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, United Kingdom;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon E. Fisher
aLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands;
cDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6500 HE Nijmegen, The Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Simon E. Fisher
  • For correspondence: simon.fisher@mpi.nl
  1. Edited by Edward M. Hubbard, University of Wisconsin–Madison, Madison, WI, and accepted by Editorial Board Member Randolph Blake January 23, 2018 (received for review September 5, 2017)

  • Article
  • Figures & SI
  • Info & Metrics
  • PDF
Loading

Online Impact

 

Article Information

vol. 115 no. 12 3168-3173
DOI: 
https://doi.org/10.1073/pnas.1715492115
PubMed: 
29507195

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue March 20, 2018.
  • Published first March 5, 2018.

Article Versions

  • Previous version (March 5, 2018 - 12:33).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Amanda K. Tilota,
  2. Katerina S. Kuceraa,
  3. Arianna Vinoa,
  4. Julian E. Asherb,
  5. Simon Baron-Cohenb,1, and
  6. Simon E. Fishera,c,1,2
  1. aLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, 6500 AH Nijmegen, The Netherlands;
  2. bAutism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge CB2 8AH, United Kingdom;
  3. cDonders Institute for Brain, Cognition and Behaviour, Radboud University, 6500 HE Nijmegen, The Netherlands
  1. Edited by Edward M. Hubbard, University of Wisconsin–Madison, Madison, WI, and accepted by Editorial Board Member Randolph Blake January 23, 2018 (received for review September 5, 2017)

Footnotes

  • ↵1S.B.-C. and S.E.F. contributed equally to this work.

  • ↵2To whom correspondence should be addressed. Email: simon.fisher{at}mpi.nl.
  • Author contributions: A.K.T., K.S.K., S.B.-C., and S.E.F. designed research; A.K.T., K.S.K., A.V., and J.E.A. performed research; A.K.T., K.S.K., A.V., and S.E.F. analyzed data; A.K.T. and S.E.F. wrote the paper; and J.E.A. and S.B.-C. collected synesthesia families.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission. E.M.H. is a guest editor invited by the Editorial Board.

  • Data deposition: The datasets generated during the current study are available upon request from The Language Archive (TLA: https://corpus1.mpi.nl/ds/asv/?0), a public data archive hosted by the Max Planck Institute for Psycholinguistics. The data are stored under the node IDs MPI1758324# and MPI1815362# and are accessible at https://hdl.handle.net/1839/00-0000-0000-001A-8756-4@view.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1715492115/-/DCSupplemental.

Cited By...

  • 19 Citations
  • 20 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Inducing synesthesia in non-synesthetes: Short-term visual deprivation facilitates auditory-evoked visual percepts
    Anupama Nair, David Brang
    Consciousness and Cognition 2019 70
  • Stochastic resonance model of synaesthesia
    Poortata Lalwani, David Brang
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • Synaesthesia: a distinct entity that is an emergent feature of adaptive neurocognitive differences
    Jamie Ward
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • Assorted dysfunctions of endosomal alkali cation/proton exchanger SLC9A6 variants linked to Christianson syndrome
    Alina Ilie, Annie Boucher, Jaeok Park, Albert Marinus Berghuis, R. Anne McKinney, John Orlowski
    Journal of Biological Chemistry 2020 295 20
  • Investigating genetic links between grapheme–colour synaesthesia and neuropsychiatric traits
    Amanda K. Tilot, Arianna Vino, Katerina S. Kucera, Duncan A. Carmichael, Loes van den Heuvel, Joery den Hoed, Anton V. Sidoroff-Dorso, Archie Campbell, David J. Porteous, Beate St Pourcain, Tessa M. van Leeuwen, Jamie Ward, Romke Rouw, Julia Simner, Simon E. Fisher
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • Learning in colour: children with grapheme-colour synaesthesia show cognitive benefits in vocabulary and self-evaluated reading
    Rebecca Smees, James Hughes, Duncan A. Carmichael, Julia Simner
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • Synesthesia & autistic features in a large family: Evidence for spatial imagery as a common factor
    Lucie Bouvet, Frédérique Amsellem, Anna Maruani, Adelaïde Tonus-Vic Dupont, Alexandre Mathieu, Thomas Bourgeron, Richard Delorme, Laurent Mottron
    Behavioural Brain Research 2019 362
  • Echoes from the past: synaesthetic colour associations reflect childhood gender stereotypes
    Nicholas B. Root, Karen Dobkins, Vilayanur S. Ramachandran, Romke Rouw
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • Synaesthetic colour associations for Japanese Kanji characters: from the perspective of grapheme learning
    Michiko Asano, So-ichiro Takahashi, Takuya Tsushiro, Kazuhiko Yokosawa
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • Reduced perceptual narrowing in synesthesia
    Daphne Maurer, Julian K. Ghloum, Laura C. Gibson, Marcus R. Watson, Lawrence M. Chen, Kathleen Akins, James T. Enns, Takao K. Hensch, Janet F. Werker
    Proceedings of the National Academy of Sciences 2020 117 18
  • Synaesthesia and autism: Different developmental outcomes from overlapping mechanisms?
    Tessa M. van Leeuwen, Janina Neufeld, James Hughes, Jamie Ward
    Cognitive Neuropsychology 2020 37 7-8
  • Bridging senses: novel insights from synaesthesia
    Simon E. Fisher, Amanda K. Tilot
    Philosophical Transactions of the Royal Society B: Biological Sciences 2019 374 1787
  • How everyday sounds can trigger strong emotions: ASMR, misophonia and the feeling of wellbeing
    Paul D. McGeoch, Romke Rouw
    BioEssays 2020 42 12
  • How far musicality and perfect pitch are derived from genetic factors?
    Krzysztof Szyfter, Michał P. Witt
    Journal of Applied Genetics 2020 61 3
  • Maternal immune activation targeted to a window of parvalbumin interneuron development improves spatial working memory: Implications for autism
    Jay P. Nakamura, Brendan Gillespie, Andrew Gibbons, Emily J. Jaehne, Xin Du, Aaron Chan, Anna Schroeder, Maarten van den Buuse, Suresh Sundram, Rachel A. Hill
    Brain, Behavior, and Immunity 2021 91
  • Multisensory Perception
    David Brang, Vilayanur S. Ramachandran
    2020
  • Substantiating synesthesia: a novel aid in a case of grapheme-colour synesthesia and concomitant dyscalculia
    Joshua J Berger, Irina M Harris, Karen M Whittingham, Zoe Terpening, John D G Watson
    Neurocase 2020 26 1
  • The Five Senses in Nabokov's Works
    Jean-Michel Hupé
    2020
  • Unlocking the Genetic Basis of Synesthesia
    Gina Shaw
    Neurology Today 2018 18 8
  • Wenn die Terz nach Sahne schmeckt
    Thomas Müller
    HNO Nachrichten 2018 48 3

Article usage

Article usage: February 2018 to January 2021

AbstractFullPdf
Feb 2018222
Mar 20181119499522200
Apr 201827292632392
May 201819341770160
Jun 201822511528135
Jul 20181824106082
Aug 20181516128791
Sep 2018955964103
Oct 201884599114
Nov 20181746183
Dec 20181334173
Total 201822519205963435
Jan 20191148545
Feb 20191441175
Mar 201929379106
Apr 201928329100
May 201910630364
Jun 20192722843
Jul 2019722747
Aug 20191017050
Sep 20191130064
Oct 20191634478
Nov 20192036867
Dec 2019823656
Total 20192873780795
Jan 202019347102
Feb 202012391101
Mar 20201630971
Apr 20201834671
May 202019375126
Jun 20201125067
Jul 20201822059
Aug 20201019656
Sep 20202428477
Oct 20205567669
Nov 202059985123
Dec 20204678968
Total 20203075168990
Jan 20212526780
Total 20212526780
Total23138298115300
PreviousNext
Back to top
Article Alerts
Email Article

Thank you for your interest in spreading the word on PNAS.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Rare variants in axonogenesis genes connect three families with sound–color synesthesia
(Your Name) has sent you a message from PNAS
(Your Name) thought you would like to see the PNAS web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Rare variants in axonogenesis genes connect three families with sound–color synesthesia
Amanda K. Tilot, Katerina S. Kucera, Arianna Vino, Julian E. Asher, Simon Baron-Cohen, Simon E. Fisher
Proceedings of the National Academy of Sciences Mar 2018, 115 (12) 3168-3173; DOI: 10.1073/pnas.1715492115

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Rare variants in axonogenesis genes connect three families with sound–color synesthesia
Amanda K. Tilot, Katerina S. Kucera, Arianna Vino, Julian E. Asher, Simon Baron-Cohen, Simon E. Fisher
Proceedings of the National Academy of Sciences Mar 2018, 115 (12) 3168-3173; DOI: 10.1073/pnas.1715492115
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Mendeley logo Mendeley
Proceedings of the National Academy of Sciences: 115 (12)
Table of Contents

Submit

Sign up for Article Alerts

Article Classifications

  • Biological Sciences
  • Neuroscience

Jump to section

  • Article
    • Abstract
    • Results
    • Discussion
    • Materials and Methods
    • Acknowledgments
    • Footnotes
    • References
  • Figures & SI
  • Info & Metrics
  • PDF

You May Also be Interested in

Abstract depiction of a guitar and musical note
Science & Culture: At the nexus of music and medicine, some see disease treatments
Although the evidence is still limited, a growing body of research suggests music may have beneficial effects for diseases such as Parkinson’s.
Image credit: Shutterstock/agsandrew.
Large piece of gold
News Feature: Tracing gold's cosmic origins
Astronomers thought they’d finally figured out where gold and other heavy elements in the universe came from. In light of recent results, they’re not so sure.
Image credit: Science Source/Tom McHugh.
Dancers in red dresses
Journal Club: Friends appear to share patterns of brain activity
Researchers are still trying to understand what causes this strong correlation between neural and social networks.
Image credit: Shutterstock/Yeongsik Im.
Yellow emoticons
Learning the language of facial expressions
Aleix Martinez explains why facial expressions often are not accurate indicators of emotion.
Listen
Past PodcastsSubscribe
Goats standing in a pin
Transplantation of sperm-producing stem cells
CRISPR-Cas9 gene editing can improve the effectiveness of spermatogonial stem cell transplantation in mice and livestock, a study finds.
Image credit: Jon M. Oatley.

Similar Articles

Site Logo
Powered by HighWire
  • Submit Manuscript
  • Twitter
  • Facebook
  • RSS Feeds
  • Email Alerts

Articles

  • Current Issue
  • Special Feature Articles – Most Recent
  • List of Issues

PNAS Portals

  • Anthropology
  • Chemistry
  • Classics
  • Front Matter
  • Physics
  • Sustainability Science
  • Teaching Resources

Information

  • Authors
  • Editorial Board
  • Reviewers
  • Librarians
  • Press
  • Site Map
  • PNAS Updates

Feedback    Privacy/Legal

Copyright © 2021 National Academy of Sciences. Online ISSN 1091-6490