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Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates
Edited by David A. Weitz, Harvard University, Cambridge, MA, and approved February 5, 2018 (received for review September 21, 2017)

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Article Information
- Published in issue March 20, 2018.
- Published first March 5, 2018.
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- Previous version (March 5, 2018 - 12:33).
- You are viewing the most recent version of this article.
Author Information
- Ze Gonga,b,c,
- Spencer E. Szczesnyd,
- Steven R. Caliarie,f,g,
- Elisabeth E. Charrierh,
- Ovijit Chaudhurii,
- Xuan Caoa,c,
- Yuan Linb,1,
- Robert L. Mauckc,d,
- Paul A. Janmeyc,h,
- Jason A. Burdickc,g, and
- Vivek B. Shenoya,c,g,1
- aDepartment of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104;
- bDepartment of Mechanical Engineering, University of Hong Kong, Hong Kong, China;
- cCenter for Engineering Mechanobiology, University of Pennsylvania, Philadelphia, PA 19104;
- dMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;
- eDepartment of Chemical Engineering, University of Virginia, Charlottesville, VA 22904;
- fDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22904;
- gDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104;
- hInstitute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104;
- iDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305
Edited by David A. Weitz, Harvard University, Cambridge, MA, and approved February 5, 2018 (received for review September 21, 2017)
Footnotes
- ↵1To whom correspondence may be addressed. Email: vshenoy{at}seas.upenn.edu or ylin{at}hku.hk.
Author contributions: V.B.S. designed research; Z.G., S.R.C., E.E.C., and O.C. performed research; Z.G., S.E.S., X.C., R.L.M., P.A.J., and J.A.B. analyzed data; Z.G., S.E.S., Y.L., and V.B.S. wrote the paper; and S.R.C., E.E.C., and O.C. conducted the experiments.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1716620115/-/DCSupplemental.
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