Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Measuring the potential for sustainable intensification of aquaculture in Bangladesh using life cycle assessment

    Patrik John Gustav Henriksson, Ben Belton, Khondker Murshed-e- Jahan, and Andreu Rico

    PNAS March 20, 2018 115 (12) 2958-2963; first published March 5, 2018. https://doi.org/10.1073/pnas.1716530115

• Applied Biological Sciences

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    Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference

    • From the Cover

    Jiahe Li, Connie Wu, Wade Wang, Yanpu He, Elad Elkayam, Leemor Joshua-Tor, and Paula T. Hammond

    PNAS March 20, 2018 115 (12) E2696-E2705; first published February 5, 2018. https://doi.org/10.1073/pnas.1719565115

    See companion article:

    • Toward new design principles for superior gene silencing

      - Mar 16, 2018
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    Layered dynamic regulation for improving metabolic pathway productivity in Escherichia coli

    Stephanie J. Doong, Apoorv Gupta, and Kristala L. J. Prather

    PNAS March 20, 2018 115 (12) 2964-2969; first published March 5, 2018. https://doi.org/10.1073/pnas.1716920115
  • Open Access

    Toward engineering E. coli with an autoregulatory system for lignin valorization

    Weihua Wu, Fang Liu, and Seema Singh

    PNAS March 20, 2018 115 (12) 2970-2975; first published March 2, 2018. https://doi.org/10.1073/pnas.1720129115

• Biochemistry

  • Open Access

    Structural basis for the role of serine-rich repeat proteins from Lactobacillus reuteri in gut microbe–host interactions

    Saannya Sequeira, Devon Kavanaugh, Donald A. MacKenzie, Tanja Šuligoj, Samuel Walpole, Charlotte Leclaire, A. Patrick Gunning, Dimitrios Latousakis, William G. T. Willats, Jesus Angulo, Changjiang Dong, and Nathalie Juge

    PNAS March 20, 2018 115 (12) E2706-E2715; first published March 5, 2018. https://doi.org/10.1073/pnas.1715016115
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    N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis

    Young Dong Yoo, Su Ran Mun, Chang Hoon Ji, Ki Woon Sung, Keum Young Kang, Ah Jung Heo, Su Hyun Lee, Jee Young An, Joonsung Hwang, Xiang-Qun Xie, Aaron Ciechanover, Bo Yeon Kim, and Yong Tae Kwon

    PNAS March 20, 2018 115 (12) E2716-E2724; first published March 5, 2018. https://doi.org/10.1073/pnas.1719110115
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    Liver X receptor β regulates the development of the dentate gyrus and autistic-like behavior in the mouse

    Yulong Cai, Xiaotong Tang, Xi Chen, Xin Li, Ying Wang, Xiaohang Bao, Lian Wang, Dayu Sun, Jinghui Zhao, Yan Xing, Margaret Warner, Haiwei Xu, Jan-Åke Gustafsson, and Xiaotang Fan

    PNAS March 20, 2018 115 (12) E2725-E2733; first published March 5, 2018. https://doi.org/10.1073/pnas.1800184115
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    dCas9-targeted locus-specific protein isolation method identifies histone gene regulators

    Chiahao Tsui, Carla Inouye, Michaella Levy, Andrew Lu, Laurence Florens, Michael P. Washburn, and Robert Tjian

    PNAS March 20, 2018 115 (12) E2734-E2741; first published March 5, 2018. https://doi.org/10.1073/pnas.1718844115
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    Allostery revealed within lipid binding events to membrane proteins

    John W. Patrick, Christopher D. Boone, Wen Liu, Gloria M. Conover, Yang Liu, Xiao Cong, and Arthur Laganowsky

    PNAS March 20, 2018 115 (12) 2976-2981; first published March 5, 2018. https://doi.org/10.1073/pnas.1719813115
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    Crystal structure of bacterial succinate:quinone oxidoreductase flavoprotein SdhA in complex with its assembly factor SdhE

    Megan J. Maher, Anuradha S. Herath, Saumya R. Udagedara, David A. Dougan, and Kaye N. Truscott

    PNAS March 20, 2018 115 (12) 2982-2987; first published March 7, 2018. https://doi.org/10.1073/pnas.1800195115
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    Assembly of the membrane domain of ATP synthase in human mitochondria

    • From the Cover

    Jiuya He, Holly C. Ford, Joe Carroll, Corsten Douglas, Evvia Gonzales, Shujing Ding, Ian M. Fearnley, and John E. Walker

    PNAS March 20, 2018 115 (12) 2988-2993; first published February 12, 2018. https://doi.org/10.1073/pnas.1722086115

    See companion article:

    • Assembling the mitochondrial ATP synthase

      - Mar 07, 2018
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    ATP-dependent substrate reduction at an [Fe₈S₉] double-cubane cluster

    Jae-Hun Jeoung and Holger Dobbek

    PNAS March 20, 2018 115 (12) 2994-2999; first published March 5, 2018. https://doi.org/10.1073/pnas.1720489115
  • Open Access

    Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis

    Benjamin H. Hudson, Andrew T. Hale, Ryan P. Irving, Shenglan Li, and John D. York

    PNAS March 20, 2018 115 (12) 3000-3005; first published March 5, 2018. https://doi.org/10.1073/pnas.1715302115
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    Exploring modular allostery via interchangeable regulatory domains

    Yifei Fan, Penelope J. Cross, Geoffrey B. Jameson, and Emily J. Parker

    PNAS March 20, 2018 115 (12) 3006-3011; first published March 5, 2018. https://doi.org/10.1073/pnas.1717621115
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    Molecular mechanism of ATP versus GTP selectivity of adenylate kinase

    Per Rogne, Marie Rosselin, Christin Grundström, Christian Hedberg, Uwe H. Sauer, and Magnus Wolf-Watz

    PNAS March 20, 2018 115 (12) 3012-3017; first published March 5, 2018. https://doi.org/10.1073/pnas.1721508115
  • Open Access

    Deciphering the reading of the genetic code by near-cognate tRNA

    Sandra Blanchet, David Cornu, Isabelle Hatin, Henri Grosjean, Pierre Bertin, and Olivier Namy

    PNAS March 20, 2018 115 (12) 3018-3023; first published March 5, 2018. https://doi.org/10.1073/pnas.1715578115
  • Open Access

    Conserved in situ arrangement of complex I and III₂ in mitochondrial respiratory chain supercomplexes of mammals, yeast, and plants

    Karen M. Davies, Thorsten B. Blum, and Werner Kühlbrandt

    PNAS March 20, 2018 115 (12) 3024-3029; first published March 8, 2018. https://doi.org/10.1073/pnas.1720702115
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    Enzymatic reconstitution of ribosomal peptide backbone thioamidation

    Nilkamal Mahanta, Andi Liu, Shihui Dong, Satish K. Nair, and Douglas A. Mitchell

    PNAS March 20, 2018 115 (12) 3030-3035; first published March 5, 2018. https://doi.org/10.1073/pnas.1722324115

• Biophysics and Computational Biology

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    Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

    Ze Gong, Spencer E. Szczesny, Steven R. Caliari, Elisabeth E. Charrier, Ovijit Chaudhuri, Xuan Cao, Yuan Lin, Robert L. Mauck, Paul A. Janmey, Jason A. Burdick, and Vivek B. Shenoy

    PNAS March 20, 2018 115 (12) E2686-E2695; first published March 5, 2018. https://doi.org/10.1073/pnas.1716620115
  • Open Access

    Conformational transitions of the sodium-dependent sugar transporter, vSGLT

    Aviv Paz, Derek P. Claxton, Jay Prakash Kumar, Kelli Kazmier, Paola Bisignano, Shruti Sharma, Shannon A. Nolte, Terrin M. Liwag, Vinod Nayak, Ernest M. Wright, Michael Grabe, Hassane S. Mchaourab, and Jeff Abramson

    PNAS March 20, 2018 115 (12) E2742-E2751; first published March 5, 2018. https://doi.org/10.1073/pnas.1718451115
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    Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor

    Yinglong Miao and J. Andrew McCammon

    PNAS March 20, 2018 115 (12) 3036-3041; first published March 5, 2018. https://doi.org/10.1073/pnas.1800756115
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    Structural basis for the alternating access mechanism of the cation diffusion facilitator YiiP

    Maria Luisa Lopez-Redondo, Nicolas Coudray, Zhening Zhang, John Alexopoulos, and David L. Stokes

    PNAS March 20, 2018 115 (12) 3042-3047; first published March 5, 2018. https://doi.org/10.1073/pnas.1715051115
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    Solution NMR structure of yeast Rcf1, a protein involved in respiratory supercomplex formation

    Shu Zhou, Pontus Pettersson, Jingjing Huang, Johannes Sjöholm, Dan Sjöstrand, Régis Pomès, Martin Högbom, Peter Brzezinski, Lena Mäler, and Pia Ädelroth

    PNAS March 20, 2018 115 (12) 3048-3053; first published March 5, 2018. https://doi.org/10.1073/pnas.1712061115
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    Protein homology model refinement by large-scale energy optimization

    Hahnbeom Park, Sergey Ovchinnikov, David E. Kim, Frank DiMaio, and David Baker

    PNAS March 20, 2018 115 (12) 3054-3059; first published March 5, 2018. https://doi.org/10.1073/pnas.1719115115
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    Guanidinium export is the primal function of SMR family transporters

    Ali A. Kermani, Christian B. Macdonald, Roja Gundepudi, and Randy B. Stockbridge

    PNAS March 20, 2018 115 (12) 3060-3065; first published March 5, 2018. https://doi.org/10.1073/pnas.1719187115
  • Open Access

    Single-molecule analysis of phospholipid scrambling by TMEM16F

    Rikiya Watanabe, Takaharu Sakuragi, Hiroyuki Noji, and Shigekazu Nagata

    PNAS March 20, 2018 115 (12) 3066-3071; first published March 5, 2018. https://doi.org/10.1073/pnas.1717956115

• Cell Biology

  • Open Access

    BRICHOS domain of Bri2 inhibits islet amyloid polypeptide (IAPP) fibril formation and toxicity in human beta cells

    Marie E. Oskarsson, Erik Hermansson, Ye Wang, Nils Welsh, Jenny Presto, Jan Johansson, and Gunilla T. Westermark

    PNAS March 20, 2018 115 (12) E2752-E2761; first published March 5, 2018. https://doi.org/10.1073/pnas.1715951115
  • Open Access

    Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL

    Yanfang Wu, Xia Li, Junying Jia, Yanpeng Zhang, Jing Li, Zhengmao Zhu, Huaqing Wang, Jie Tang, and Junjie Hu

    PNAS March 20, 2018 115 (12) E2762-E2771; first published March 5, 2018. https://doi.org/10.1073/pnas.1716439115

• Developmental Biology

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    MAPK signaling couples SCF-mediated degradation of translational regulators to oocyte meiotic progression

    Edyta Kisielnicka, Ryuji Minasaki, and Christian R. Eckmann

    PNAS March 20, 2018 115 (12) E2772-E2781; first published March 1, 2018. https://doi.org/10.1073/pnas.1715439115

• Ecology

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    Convergence of marine megafauna movement patterns in coastal and open oceans

    • From the Cover

    A. M. M. Sequeira, J. P. Rodríguez, V. M. Eguíluz, R. Harcourt, M. Hindell, D. W. Sims, C. M. Duarte, D. P. Costa, J. Fernández-Gracia, L. C. Ferreira, G. C. Hays, M. R. Heupel, M. G. Meekan, A. Aven, F. Bailleul, A. M. M. Baylis, M. L. Berumen, C. D. Braun, J. Burns, M. J. Caley, R. Campbell, R. H. Carmichael, E. Clua, L. D. Einoder, Ari Friedlaender, M. E. Goebel, S. D. Goldsworthy, C. Guinet, J. Gunn, D. Hamer, N. Hammerschlag, M. Hammill, L. A. Hückstädt, N. E. Humphries, M.-A. Lea, A. Lowther, A. Mackay, E. McHuron, J. McKenzie, L. McLeay, C. R. McMahon, K. Mengersen, M. M. C. Muelbert, A. M. Pagano, B. Page, N. Queiroz, P. W. Robinson, S. A. Shaffer, M. Shivji, G. B. Skomal, S. R. Thorrold, S. Villegas-Amtmann, M. Weise, R. Wells, B. Wetherbee, A. Wiebkin, B. Wienecke, and M. Thums

    PNAS March 20, 2018 115 (12) 3072-3077; first published February 26, 2018. https://doi.org/10.1073/pnas.1716137115
  • Open Access

    The seasonality of nonpolio enteroviruses in the United States: Patterns and drivers

    Margarita Pons-Salort, M. Steven Oberste, Mark A. Pallansch, Glen R. Abedi, Saki Takahashi, Bryan T. Grenfell, and Nicholas C. Grassly

    PNAS March 20, 2018 115 (12) 3078-3083; first published March 5, 2018. https://doi.org/10.1073/pnas.1721159115
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    Biogeographical disparity in the functional diversity and redundancy of corals

    Mike McWilliam, Mia O. Hoogenboom, Andrew H. Baird, Chao-Yang Kuo, Joshua S. Madin, and Terry P. Hughes

    PNAS March 20, 2018 115 (12) 3084-3089; first published March 5, 2018. https://doi.org/10.1073/pnas.1716643115

• Environmental Sciences

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    Modeling environmentally mediated rotavirus transmission: The role of temperature and hydrologic factors

    Alicia N. M. Kraay, Andrew F. Brouwer, Nan Lin, Philip A. Collender, Justin V. Remais, and Joseph N. S. Eisenberg

    PNAS March 20, 2018 115 (12) E2782-E2790; first published March 1, 2018. https://doi.org/10.1073/pnas.1719579115

• Evolution

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    Adaptive evolution of genomically recoded Escherichia coli

    • From the Cover

    Timothy M. Wannier, Aditya M. Kunjapur, Daniel P. Rice, Michael J. McDonald, Michael M. Desai, and George M. Church

    PNAS March 20, 2018 115 (12) 3090-3095; first published February 13, 2018. https://doi.org/10.1073/pnas.1715530115

    See companion article:

    • Experimental evolution heals the scars of genome-scale recoding

      - Mar 07, 2018
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    Genetic signatures of microbial altruism and cheating in social amoebas in the wild

    Suegene Noh, Katherine S. Geist, Xiangjun Tian, Joan E. Strassmann, and David C. Queller

    PNAS March 20, 2018 115 (12) 3096-3101; first published March 5, 2018. https://doi.org/10.1073/pnas.1720324115
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    Vaccination can drive an increase in frequencies of antibiotic resistance among nonvaccine serotypes of Streptococcus pneumoniae

    Uri Obolski, José Lourenço, Craig Thompson, Robin Thompson, Andrea Gori, and Sunetra Gupta

    PNAS March 20, 2018 115 (12) 3102-3107; first published March 6, 2018. https://doi.org/10.1073/pnas.1718712115

• Genetics

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    Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans

    Yonghak Seo, Samuel Kingsley, Griffin Walker, Michelle A. Mondoux, and Heidi A. Tissenbaum

    PNAS March 20, 2018 115 (12) E2791-E2800; first published March 6, 2018. https://doi.org/10.1073/pnas.1714178115
  • Open Access

    RNAi is a critical determinant of centromere evolution in closely related fungi

    Vikas Yadav, Sheng Sun, R. Blake Billmyre, Bhagya C. Thimmappa, Terrance Shea, Robert Lintner, Guus Bakkeren, Christina A. Cuomo, Joseph Heitman, and Kaustuv Sanyal

    PNAS March 20, 2018 115 (12) 3108-3113; first published March 5, 2018. https://doi.org/10.1073/pnas.1713725115
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    Intermediate filament accumulation can stabilize microtubules in Caenorhabditis elegans motor neurons

    Naina Kurup, Yunbo Li, Alexandr Goncharov, and Yishi Jin

    PNAS March 20, 2018 115 (12) 3114-3119; first published March 6, 2018. https://doi.org/10.1073/pnas.1721930115

• Immunology and Inflammation

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    Noninvasive detection of macrophage activation with single-cell resolution through machine learning

    Nicolas Pavillon, Alison J. Hobro, Shizuo Akira, and Nicholas I. Smith

    PNAS March 20, 2018 115 (12) E2676-E2685; first published March 6, 2018. https://doi.org/10.1073/pnas.1711872115
  • Open Access

    Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells

    Thomas Patzelt, Selina J. Keppler, Oliver Gorka, Silvia Thoene, Tim Wartewig, Michael Reth, Irmgard Förster, Roland Lang, Maike Buchner, and Jürgen Ruland

    PNAS March 20, 2018 115 (12) 3120-3125; first published March 5, 2018. https://doi.org/10.1073/pnas.1711335115
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    B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destruction

    Ling Chen, Takeshi Azuma, Weiwei Yu, Xu Zheng, Liqun Luo, and Lieping Chen

    PNAS March 20, 2018 115 (12) 3126-3131; first published March 5, 2018. https://doi.org/10.1073/pnas.1722043115

• Medical Sciences

  • Open Access

    Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition

    Emanuele Giurisato, Qiuping Xu, Silvia Lonardi, Brian Telfer, Ilaria Russo, Adam Pearson, Katherine G. Finegan, Wenbin Wang, Jinhua Wang, Nathanael S. Gray, William Vermi, Zhengui Xia, and Cathy Tournier

    PNAS March 20, 2018 115 (12) E2801-E2810; first published March 5, 2018. https://doi.org/10.1073/pnas.1707929115
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    Peptides of pHLIP family for targeted intracellular and extracellular delivery of cargo molecules to tumors

    Linden C. Wyatt, Anna Moshnikova, Troy Crawford, Donald M. Engelman, Oleg A. Andreev, and Yana K. Reshetnyak

    PNAS March 20, 2018 115 (12) E2811-E2818; first published March 5, 2018. https://doi.org/10.1073/pnas.1715350115
  • Open Access

    hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process

    Francesca Di Modugno, Valentina Caprara, Lidia Chellini, Piera Tocci, Francesca Spadaro, Gabriella Ferrandina, Andrea Sacconi, Giovanni Blandino, Paola Nisticò, Anna Bagnato, and Laura Rosanò

    PNAS March 20, 2018 115 (12) 3132-3137; first published February 8, 2018. https://doi.org/10.1073/pnas.1715998115

    See companion article:

    • β-Arrestin1 mediates hMENA expression and ovarian cancer metastasis

      - Mar 07, 2018
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    High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism

    Miguel A. Lanaspa, Masanari Kuwabara, Ana Andres-Hernando, Nanxing Li, Christina Cicerchi, Thomas Jensen, David J. Orlicky, Carlos A. Roncal-Jimenez, Takuji Ishimoto, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Paul S. MacLean, and Richard J. Johnson

    PNAS March 20, 2018 115 (12) 3138-3143; first published March 5, 2018. https://doi.org/10.1073/pnas.1713837115

• Microbiology

  • Open Access

    Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

    Vasilios Kalas, Michael E. Hibbing, Amarendar Reddy Maddirala, Ryan Chugani, Jerome S. Pinkner, Laurel K. Mydock-McGrane, Matt S. Conover, James W. Janetka, and Scott J. Hultgren

    PNAS March 20, 2018 115 (12) E2819-E2828; first published March 5, 2018. https://doi.org/10.1073/pnas.1720140115
  • Open Access

    MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity

    Daniel K. W. Chu, Kenrie P. Y. Hui, Ranawaka A. P. M. Perera, Eve Miguel, Daniela Niemeyer, Jincun Zhao, Rudragouda Channappanavar, Gytis Dudas, Jamiu O. Oladipo, Amadou Traoré, Ouafaa Fassi-Fihri, Abraham Ali, Getnet F. Demissié, Doreen Muth, Michael C. W. Chan, John M. Nicholls, David K. Meyerholz, Sulyman A. Kuranga, Gezahegne Mamo, Ziqi Zhou, Ray T. Y. So, Maged G. Hemida, Richard J. Webby, Francois Roger, Andrew Rambaut, Leo L. M. Poon, Stanley Perlman, Christian Drosten, Veronique Chevalier, and Malik Peiris

    PNAS March 20, 2018 115 (12) 3144-3149; first published March 5, 2018. https://doi.org/10.1073/pnas.1718769115
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    Conserved mechanism of cell-wall synthase regulation revealed by the identification of a new PBP activator in Pseudomonas aeruginosa

    Neil G. Greene, Coralie Fumeaux, and Thomas G. Bernhardt

    PNAS March 20, 2018 115 (12) 3150-3155; first published March 5, 2018. https://doi.org/10.1073/pnas.1717925115

• Neuroscience

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    Communicating the nutritional value of sugar in Drosophila

    Farhan Abu, Justin G. Wang, Yangkyun Oh, Jingjing Deng, Thomas A. Neubert, and Greg S. B. Suh

    PNAS March 20, 2018 115 (12) E2829-E2838; first published March 5, 2018. https://doi.org/10.1073/pnas.1719827115
  • Open Access

    BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure

    Karina E. Guziewicz, Artur V. Cideciyan, William A. Beltran, András M. Komáromy, Valerie L. Dufour, Malgorzata Swider, Simone Iwabe, Alexander Sumaroka, Brian T. Kendrick, Gordon Ruthel, Vince A. Chiodo, Elise Héon, William W. Hauswirth, Samuel G. Jacobson, and Gustavo D. Aguirre

    PNAS March 20, 2018 115 (12) E2839-E2848; first published March 5, 2018. https://doi.org/10.1073/pnas.1720662115
  • Open Access

    Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay

    Andrew D. Nguyen, Thi A. Nguyen, Jiasheng Zhang, Swathi Devireddy, Ping Zhou, Anna M. Karydas, Xialian Xu, Bruce L. Miller, Frank Rigo, Shawn M. Ferguson, Eric J. Huang, Tobias C. Walther, and Robert V. Farese Jr.

    PNAS March 20, 2018 115 (12) E2849-E2858; first published March 6, 2018. https://doi.org/10.1073/pnas.1722344115
  • Open Access

    hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons

    Michael Briese, Lena Saal-Bauernschubert, Changhe Ji, Mehri Moradi, Hanaa Ghanawi, Michael Uhl, Silke Appenzeller, Rolf Backofen, and Michael Sendtner

    PNAS March 20, 2018 115 (12) E2859-E2868; first published March 5, 2018. https://doi.org/10.1073/pnas.1721670115
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    Dynamic patterns of cortical expansion during folding of the preterm human brain

    Kara E. Garcia, Emma C. Robinson, Dimitrios Alexopoulos, Donna L. Dierker, Matthew F. Glasser, Timothy S. Coalson, Cynthia M. Ortinau, Daniel Rueckert, Larry A. Taber, David C. Van Essen, Cynthia E. Rogers, Christopher D. Smyser, and Philip V. Bayly

    PNAS March 20, 2018 115 (12) 3156-3161; first published March 5, 2018. https://doi.org/10.1073/pnas.1715451115
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    Susceptibility of brain atrophy to TRIB3 in Alzheimer’s disease, evidence from functional prioritization in imaging genetics

    Marco Lorenzi, Andre Altmann, Boris Gutman, Selina Wray, Charles Arber, Derrek P. Hibar, Neda Jahanshad, Jonathan M. Schott, Daniel C. Alexander, Paul M. Thompson, Sebastien Ourselin, and for the Alzheimer’s Disease Neuroimaging Initiative

    PNAS March 20, 2018 115 (12) 3162-3167; first published March 6, 2018. https://doi.org/10.1073/pnas.1706100115
  • Open Access

    Rare variants in axonogenesis genes connect three families with sound–color synesthesia

    Amanda K. Tilot, Katerina S. Kucera, Arianna Vino, Julian E. Asher, Simon Baron-Cohen, and Simon E. Fisher

    PNAS March 20, 2018 115 (12) 3168-3173; first published March 5, 2018. https://doi.org/10.1073/pnas.1715492115

• Physiology

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    Physical and geometric constraints shape the labyrinth-like nasal cavity

    David Zwicker, Rodolfo Ostilla-Mónico, Daniel E. Lieberman, and Michael P. Brenner

    PNAS March 20, 2018 115 (12) 2936-2941; first published March 5, 2018. https://doi.org/10.1073/pnas.1714795115

• Plant Biology

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    Simultaneous imaging and functional studies reveal a tight correlation between calcium and actin networks

    Carlisle S. Bascom Jr., Lawrence J. Winship, and Magdalena Bezanilla

    PNAS March 20, 2018 115 (12) E2869-E2878; first published March 5, 2018. https://doi.org/10.1073/pnas.1711037115
  • Open Access

    Loss of function of a rice TPR-domain RNA-binding protein confers broad-spectrum disease resistance

    • From the Cover

    Xiaogang Zhou, Haicheng Liao, Mawsheng Chern, Junjie Yin, Yufei Chen, Jianping Wang, Xiaobo Zhu, Zhixiong Chen, Can Yuan, Wen Zhao, Jing Wang, Weitao Li, Min He, Bingtian Ma, Jichun Wang, Peng Qin, Weilan Chen, Yuping Wang, Jiali Liu, Yangwen Qian, Wenming Wang, Xianjun Wu, Ping Li, Lihuang Zhu, Shigui Li, Pamela C. Ronald, and Xuewei Chen

    PNAS March 20, 2018 115 (12) 3174-3179; first published February 5, 2018. https://doi.org/10.1073/pnas.1705927115

    See companion article:

    • Breeding plant broad-spectrum resistance without yield penalties

      - Mar 07, 2018
  • Open Access

    Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine

    Yang Qu, Michael E. A. M. Easson, Razvan Simionescu, Josef Hajicek, Antje M. K. Thamm, Vonny Salim, and Vincenzo De Luca

    PNAS March 20, 2018 115 (12) 3180-3185; first published March 6, 2018. https://doi.org/10.1073/pnas.1719979115

• Psychological and Cognitive Sciences

  • Open Access

    Integration of speed and time for estimating time to contact

    Chia-Jung Chang and Mehrdad Jazayeri

    PNAS March 20, 2018 115 (12) E2879-E2887; first published March 5, 2018. https://doi.org/10.1073/pnas.1713316115
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    How cognitive and reactive fear circuits optimize escape decisions in humans

    Song Qi, Demis Hassabis, Jiayin Sun, Fangjian Guo, Nathaniel Daw, and Dean Mobbs

    PNAS March 20, 2018 115 (12) 3186-3191; first published March 5, 2018. https://doi.org/10.1073/pnas.1712314115

• Sustainability Science

  • Open Access

    Citywide cluster randomized trial to restore blighted vacant land and its effects on violence, crime, and fear

    Charles C. Branas, Eugenia South, Michelle C. Kondo, Bernadette C. Hohl, Philippe Bourgois, Douglas J. Wiebe, and John M. MacDonald

    PNAS March 20, 2018 115 (12) 2946-2951; first published February 26, 2018. https://doi.org/10.1073/pnas.1718503115

• Systems Biology

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    Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation

    Simon Mitchell, Koushik Roy, Thomas A. Zangle, and Alexander Hoffmann

    PNAS March 20, 2018 115 (12) E2888-E2897; first published March 7, 2018. https://doi.org/10.1073/pnas.1715639115