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Research Article

DEC2 modulates orexin expression and regulates sleep

Arisa Hirano, Pei-Ken Hsu, Luoying Zhang, Lijuan Xing, Thomas McMahon, Maya Yamazaki, Louis J. Ptáček, and Ying-Hui Fu
PNAS March 27, 2018 115 (13) 3434-3439; first published March 12, 2018; https://doi.org/10.1073/pnas.1801693115
Arisa Hirano
aDepartment of Neurology, University of California, San Francisco, CA 94143;
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Pei-Ken Hsu
aDepartment of Neurology, University of California, San Francisco, CA 94143;
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Luoying Zhang
aDepartment of Neurology, University of California, San Francisco, CA 94143;
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Lijuan Xing
aDepartment of Neurology, University of California, San Francisco, CA 94143;
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Thomas McMahon
aDepartment of Neurology, University of California, San Francisco, CA 94143;
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Maya Yamazaki
aDepartment of Neurology, University of California, San Francisco, CA 94143;
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Louis J. Ptáček
aDepartment of Neurology, University of California, San Francisco, CA 94143;
bWeill Neuroscience Institute, University of California, San Francisco, CA 94143;
cKavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94143;
dHoward Hughes Medical Institute, University of California, San Francisco, CA 94143
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  • For correspondence: ljp@ucsf.edu Ying-Hui.fu@ucsf.edu
Ying-Hui Fu
aDepartment of Neurology, University of California, San Francisco, CA 94143;
bWeill Neuroscience Institute, University of California, San Francisco, CA 94143;
cKavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94143;
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  • For correspondence: ljp@ucsf.edu Ying-Hui.fu@ucsf.edu
  1. Contributed by Louis J. Ptáček, February 12, 2018 (sent for review December 4, 2017; reviewed by Ken-ichi Honma and Toru Takumi)

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Article Information

vol. 115 no. 13 3434-3439
DOI: 
https://doi.org/10.1073/pnas.1801693115
PubMed: 
29531056

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue March 27, 2018.
  • Published first March 12, 2018.

Article Versions

  • Previous version (March 12, 2018 - 12:08).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2018 Published under the PNAS license.

Author Information

  1. Arisa Hiranoa,
  2. Pei-Ken Hsua,
  3. Luoying Zhanga,1,
  4. Lijuan Xinga,
  5. Thomas McMahona,
  6. Maya Yamazakia,
  7. Louis J. Ptáčeka,b,c,d,2, and
  8. Ying-Hui Fua,b,c,2
  1. aDepartment of Neurology, University of California, San Francisco, CA 94143;
  2. bWeill Neuroscience Institute, University of California, San Francisco, CA 94143;
  3. cKavli Institute for Fundamental Neuroscience, University of California, San Francisco, CA 94143;
  4. dHoward Hughes Medical Institute, University of California, San Francisco, CA 94143
  1. Contributed by Louis J. Ptáček, February 12, 2018 (sent for review December 4, 2017; reviewed by Ken-ichi Honma and Toru Takumi)

Footnotes

  • ↵1Present address: College of Life Science and Technology and the collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, China.

  • ↵2To whom correspondence may be addressed. Email: ljp{at}ucsf.edu or Ying-Hui.fu{at}ucsf.edu.
  • Author contributions: A.H., L.J.P., and Y.-H.F. designed research; A.H., P.-K.H., L.Z., L.X., T.M., and M.Y. performed research; A.H. analyzed data; and A.H., L.J.P., and Y.-H.F. wrote the paper.

  • Reviewers: K.-i.H., Hokkaido University Graduate School of Medicine; and T.T., RIKEN Brain Science Institute.

  • The authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1801693115/-/DCSupplemental.

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Article usage

Article usage: March 2018 to January 2021

AbstractFullPdf
Mar 20183476350200
Apr 201892412590
May 201871312332
Jun 201810247032
Jul 201810194721
Aug 20185252710
Sep 20183728444
Oct 20189018583
Nov 201810217070
Dec 20186313949
Total 201883081320631
Jan 20198617464
Feb 20199314678
Mar 201912218082
Apr 2019137182120
May 201920813686
Jun 201910614854
Jul 20198811869
Aug 2019155124142
Sep 2019173187132
Oct 2019210232151
Nov 20199117689
Dec 201966157114
Total 2019153519601181
Jan 202060403148
Feb 202056381132
Mar 202065380133
Apr 202057251114
May 20206423593
Jun 20204029072
Jul 20204919558
Aug 20205323759
Sep 202075217130
Oct 202080254104
Nov 20208926792
Dec 20207225668
Total 202076033661203
Jan 20216021991
Total 20216021991
Total1066368653106
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DEC2 modulates orexin expression and regulates sleep
Arisa Hirano, Pei-Ken Hsu, Luoying Zhang, Lijuan Xing, Thomas McMahon, Maya Yamazaki, Louis J. Ptáček, Ying-Hui Fu
Proceedings of the National Academy of Sciences Mar 2018, 115 (13) 3434-3439; DOI: 10.1073/pnas.1801693115

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DEC2 modulates orexin expression and regulates sleep
Arisa Hirano, Pei-Ken Hsu, Luoying Zhang, Lijuan Xing, Thomas McMahon, Maya Yamazaki, Louis J. Ptáček, Ying-Hui Fu
Proceedings of the National Academy of Sciences Mar 2018, 115 (13) 3434-3439; DOI: 10.1073/pnas.1801693115
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