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Research Article

Global increase and geographic convergence in antibiotic consumption between 2000 and 2015

View ORCID ProfileEili Y. Klein, Thomas P. Van Boeckel, Elena M. Martinez, Suraj Pant, Sumanth Gandra, Simon A. Levin, Herman Goossens, and View ORCID ProfileRamanan Laxminarayan
  1. aCenter for Disease Dynamics, Economics & Policy, Washington, DC 20005;
  2. bDepartment of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21209;
  3. cDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205;
  4. dInstitute of Integrative Biology, ETH Zürich, CH-8006 Zürich, Switzerland;
  5. eDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544;
  6. fPrinceton Environmental Institute, Princeton University, Princeton, NJ 08544;
  7. gBeijer Institute of Ecological Economics, SE-104 05 Stockholm, Sweden;
  8. hLaboratory of Medical Microbiology, Vaccine & Infectious Diseases Institute, University of Antwerp, 2610 Antwerp, Belgium;
  9. iDepartment of Global Health, University of Washington, Seattle, WA 98104

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PNAS April 10, 2018 115 (15) E3463-E3470; first published March 26, 2018; https://doi.org/10.1073/pnas.1717295115
Eili Y. Klein
aCenter for Disease Dynamics, Economics & Policy, Washington, DC 20005;
bDepartment of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21209;
cDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205;
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  • ORCID record for Eili Y. Klein
  • For correspondence: klein@cddep.org slevin@princeton.edu
Thomas P. Van Boeckel
dInstitute of Integrative Biology, ETH Zürich, CH-8006 Zürich, Switzerland;
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Elena M. Martinez
aCenter for Disease Dynamics, Economics & Policy, Washington, DC 20005;
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Suraj Pant
aCenter for Disease Dynamics, Economics & Policy, Washington, DC 20005;
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Sumanth Gandra
aCenter for Disease Dynamics, Economics & Policy, Washington, DC 20005;
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Simon A. Levin
eDepartment of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544;
fPrinceton Environmental Institute, Princeton University, Princeton, NJ 08544;
gBeijer Institute of Ecological Economics, SE-104 05 Stockholm, Sweden;
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  • For correspondence: klein@cddep.org slevin@princeton.edu
Herman Goossens
hLaboratory of Medical Microbiology, Vaccine & Infectious Diseases Institute, University of Antwerp, 2610 Antwerp, Belgium;
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Ramanan Laxminarayan
aCenter for Disease Dynamics, Economics & Policy, Washington, DC 20005;
fPrinceton Environmental Institute, Princeton University, Princeton, NJ 08544;
iDepartment of Global Health, University of Washington, Seattle, WA 98104
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  1. Contributed by Simon A. Levin, February 23, 2018 (sent for review October 3, 2017; reviewed by Bruce R. Levin and Dominique L. Monnet)

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Significance

Antibiotic resistance, driven by antibiotic consumption, is a growing global health threat. Our report on antibiotic use in 76 countries over 16 years provides an up-to-date comprehensive assessment of global trends in antibiotic consumption. We find that the antibiotic consumption rate in low- and middle-income countries (LMICs) has been converging to (and in some countries surpassing) levels typically observed in high-income countries. However, inequities in drug access persist, as many LMICs continue to be burdened with high rates of infectious disease-related mortality and low rates of antibiotic consumption. Our findings emphasize the need for global surveillance of antibiotic consumption to support policies to reduce antibiotic consumption and resistance while providing access to these lifesaving drugs.

Abstract

Tracking antibiotic consumption patterns over time and across countries could inform policies to optimize antibiotic prescribing and minimize antibiotic resistance, such as setting and enforcing per capita consumption targets or aiding investments in alternatives to antibiotics. In this study, we analyzed the trends and drivers of antibiotic consumption from 2000 to 2015 in 76 countries and projected total global antibiotic consumption through 2030. Between 2000 and 2015, antibiotic consumption, expressed in defined daily doses (DDD), increased 65% (21.1–34.8 billion DDDs), and the antibiotic consumption rate increased 39% (11.3–15.7 DDDs per 1,000 inhabitants per day). The increase was driven by low- and middle-income countries (LMICs), where rising consumption was correlated with gross domestic product per capita (GDPPC) growth (P = 0.004). In high-income countries (HICs), although overall consumption increased modestly, DDDs per 1,000 inhabitants per day fell 4%, and there was no correlation with GDPPC. Of particular concern was the rapid increase in the use of last-resort compounds, both in HICs and LMICs, such as glycylcyclines, oxazolidinones, carbapenems, and polymyxins. Projections of global antibiotic consumption in 2030, assuming no policy changes, were up to 200% higher than the 42 billion DDDs estimated in 2015. Although antibiotic consumption rates in most LMICs remain lower than in HICs despite higher bacterial disease burden, consumption in LMICs is rapidly converging to rates similar to HICs. Reducing global consumption is critical for reducing the threat of antibiotic resistance, but reduction efforts must balance access limitations in LMICs and take account of local and global resistance patterns.

  • antimicrobial resistance
  • low-income countries
  • defined daily doses
  • antibiotic stewardship
  • antibiotics

Footnotes

  • ↵1To whom correspondence may be addressed. Email: klein{at}cddep.org or slevin{at}princeton.edu.
  • Author contributions: E.Y.K. and R.L. designed research; E.Y.K. performed research; E.Y.K., E.M.M., and S.P. analyzed data; and E.Y.K., T.P.V.B., E.M.M., S.G., S.A.L., H.G., and R.L. wrote the paper.

  • Reviewers: B.R.L., Emory University; and D.L.M., European Centre for Disease Prevention and Control.

  • The authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1717295115/-/DCSupplemental.

  • Copyright © 2018 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Global increase and geographic convergence in antibiotic consumption between 2000 and 2015
Eili Y. Klein, Thomas P. Van Boeckel, Elena M. Martinez, Suraj Pant, Sumanth Gandra, Simon A. Levin, Herman Goossens, Ramanan Laxminarayan
Proceedings of the National Academy of Sciences Apr 2018, 115 (15) E3463-E3470; DOI: 10.1073/pnas.1717295115

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Global increase and geographic convergence in antibiotic consumption between 2000 and 2015
Eili Y. Klein, Thomas P. Van Boeckel, Elena M. Martinez, Suraj Pant, Sumanth Gandra, Simon A. Levin, Herman Goossens, Ramanan Laxminarayan
Proceedings of the National Academy of Sciences Apr 2018, 115 (15) E3463-E3470; DOI: 10.1073/pnas.1717295115
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Article Classifications

  • Biological Sciences
  • Environmental Sciences

This article has Letters. Please see:

  • Relationship between Research Article and Letter - August 07, 2018
  • Relationship between Research Article and Letter - November 13, 2018

See related content:

  • Reply to Charra et al.: Global longitudinal assessment of 2019 changes in defined daily doses
    - Nov 13, 2018
  • Reply to Abat et al.: Improved policies necessary to ensure an effective future for antibiotics
    - Aug 07, 2018
Proceedings of the National Academy of Sciences: 115 (15)
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