New Research In
Physical Sciences
Social Sciences
Featured Portals
Articles by Topic
Biological Sciences
Featured Portals
Articles by Topic
- Agricultural Sciences
- Anthropology
- Applied Biological Sciences
- Biochemistry
- Biophysics and Computational Biology
- Cell Biology
- Developmental Biology
- Ecology
- Environmental Sciences
- Evolution
- Genetics
- Immunology and Inflammation
- Medical Sciences
- Microbiology
- Neuroscience
- Pharmacology
- Physiology
- Plant Biology
- Population Biology
- Psychological and Cognitive Sciences
- Sustainability Science
- Systems Biology
About the Cover
April 17, 2018; vol. 115 no. 16
This Week in PNAS
Letters (Online Only)
- You have accessGenetic variation in VAC14 is associated with bacteremia secondary to diverse pathogens in African childrenJames J. Gilchrist, Alexander J. Mentzer, Anna Rautanen, Matti Pirinen, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Wellcome Trust Case-Control Consortium 2, The Kenyan Bacteraemia Study Group, Thomas N. Williams, J. Anthony G. Scott, and Adrian V. S. HillPNAS April 17, 2018 115 (16) E3601-E3603; published ahead of print March 27, 2018. https://doi.org/10.1073/pnas.1802071115
- You have accessReply to Gilchrist et al.: Possible roles for VAC14 in multiple infectious diseasesMonica I. Alvarez and Dennis C. KoPNAS April 17, 2018 115 (16) E3604-E3605; published ahead of print March 27, 2018. https://doi.org/10.1073/pnas.1803533115
- You have accessDoes selecting ligand shape γδ-TCR repertoire?Yueh-hsiu ChienPNAS April 17, 2018 115 (16) E3606; published ahead of print April 3, 2018. https://doi.org/10.1073/pnas.1804001115
- You have accessReply to Chien: Clarification of the effect of ligand on γδ-TCR repertoire selectionShawn P. Fahl and David L. WiestPNAS April 17, 2018 115 (16) E3607-E3608; published ahead of print April 3, 2018. https://doi.org/10.1073/pnas.1804193115
News Feature
An in-depth look at trending science issues.
PNAS Plus Significance Statements
Brief statements written by the authors about the significance of their papers.
Perspective
- You have accessProcesses and patterns of interaction as units of selection: An introduction to ITSNTS thinkingW. Ford Doolittle and S. Andrew InkpenPNAS April 17, 2018 115 (16) 4006-4014; published ahead of print March 26, 2018. https://doi.org/10.1073/pnas.1722232115
Climate Change, Policy, and Carbon Sequestration in China Special Feature (Free Online)
Introduction
- You have accessClimate change, human impacts, and carbon sequestration in China
- From the Cover
Jingyun Fang, Guirui Yu, Lingli Liu, Shuijin Hu, and F. Stuart Chapin IIIPNAS April 17, 2018 115 (16) 4015-4020; published ahead of print April 17, 2018. https://doi.org/10.1073/pnas.1700304115
Research Articles
- You have accessCarbon pools in China’s terrestrial ecosystems: New estimates based on an intensive field surveyXuli Tang, Xia Zhao, Yongfei Bai, Zhiyao Tang, Wantong Wang, Yongcun Zhao, Hongwei Wan, Zongqiang Xie, Xuezheng Shi, Bingfang Wu, Gengxu Wang, Junhua Yan, Keping Ma, Sheng Du, Shenggong Li, Shijie Han, Youxin Ma, Huifeng Hu, Nianpeng He, Yuanhe Yang, Wenxuan Han, Hongling He, Guirui Yu, Jingyun Fang, and Guoyi Zhou
- You have accessPlant diversity enhances productivity and soil carbon storageShiping Chen, Wantong Wang, Wenting Xu, Yang Wang, Hongwei Wan, Dima Chen, Zhiyao Tang, Xuli Tang, Guoyi Zhou, Zongqiang Xie, Daowei Zhou, Zhouping Shangguan, Jianhui Huang, Jin-Sheng He, Yanfen Wang, Jiandong Sheng, Lisong Tang, Xinrong Li, Ming Dong, Yan Wu, Qiufeng Wang, Zhiheng Wang, Jianguo Wu, F. Stuart Chapin III, and Yongfei Bai
- You have accessPatterns of plant carbon, nitrogen, and phosphorus concentration in relation to productivity in China’s terrestrial ecosystemsZhiyao Tang, Wenting Xu, Guoyi Zhou, Yongfei Bai, Jiaxiang Li, Xuli Tang, Dima Chen, Qing Liu, Wenhong Ma, Gaoming Xiong, Honglin He, Nianpeng He, Yanpei Guo, Qiang Guo, Jiangling Zhu, Wenxuan Han, Huifeng Hu, Jingyun Fang, and Zongqiang XiePNAS April 17, 2018 115 (16) 4033-4038; published ahead of print April 16, 2018. https://doi.org/10.1073/pnas.1700295114
- You have accessEffects of national ecological restoration projects on carbon sequestration in China from 2001 to 2010Fei Lu, Huifeng Hu, Wenjuan Sun, Jiaojun Zhu, Guobin Liu, Wangming Zhou, Quanfa Zhang, Peili Shi, Xiuping Liu, Xing Wu, Lu Zhang, Xiaohua Wei, Limin Dai, Kerong Zhang, Yirong Sun, Sha Xue, Wanjun Zhang, Dingpeng Xiong, Lei Deng, Bojie Liu, Li Zhou, Chao Zhang, Xiao Zheng, Jiansheng Cao, Yao Huang, Nianpeng He, Guoyi Zhou, Yongfei Bai, Zongqiang Xie, Zhiyao Tang, Bingfang Wu, Jingyun Fang, Guohua Liu, and Guirui Yu
- You have accessEconomics- and policy-driven organic carbon input enhancement dominates soil organic carbon accumulation in Chinese croplandsYongcun Zhao, Meiyan Wang, Shuijin Hu, Xudong Zhang, Zhu Ouyang, Ganlin Zhang, Biao Huang, Shiwei Zhao, Jinshui Wu, Deti Xie, Bo Zhu, Dongsheng Yu, Xianzhang Pan, Shengxiang Xu, and Xuezheng Shi
- You have accessShifting plant species composition in response to climate change stabilizes grassland primary productionHuiying Liu, Zhaorong Mi, Li Lin, Yonghui Wang, Zhenhua Zhang, Fawei Zhang, Hao Wang, Lingli Liu, Biao Zhu, Guangmin Cao, Xinquan Zhao, Nathan J. Sanders, Aimée T. Classen, Peter B. Reich, and Jin-Sheng He
Physical Sciences
Applied Mathematics
- Open AccessMultiscale mixing patterns in networksLeto Peel, Jean-Charles Delvenne, and Renaud LambiottePNAS April 17, 2018 115 (16) 4057-4062; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1713019115
Applied Physical Sciences
- You have accessThermodynamic limits of energy harvesting from outgoing thermal radiationSiddharth Buddhiraju, Parthiban Santhanam, and Shanhui FanPNAS April 17, 2018 115 (16) E3609-E3615; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1717595115
- You have accessDramatic pressure-sensitive ion conduction in conical nanoporesLaetitia Jubin, Anthony Poggioli, Alessandro Siria, and Lydéric BocquetPNAS April 17, 2018 115 (16) 4063-4068; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1721987115
Biophysics and Computational Biology
- You have accessRoll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D mediaAlejandro Bilbao, Amar K. Patel, Mizanur Rahman, Siva A. Vanapalli, and Jerzy BlawzdziewiczPNAS April 17, 2018 115 (16) E3616-E3625; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1706754115
- Open AccessAccurate and sensitive quantification of protein-DNA binding affinityChaitanya Rastogi, H. Tomas Rube, Judith F. Kribelbauer, Justin Crocker, Ryan E. Loker, Gabriella D. Martini, Oleg Laptenko, William A. Freed-Pastor, Carol Prives, David L. Stern, Richard S. Mann, and Harmen J. BussemakerPNAS April 17, 2018 115 (16) E3692-E3701; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1714376115
- Open AccessComprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor bindingDaniel D. Le, Tyler C. Shimko, Arjun K. Aditham, Allison M. Keys, Scott A. Longwell, Yaron Orenstein, and Polly M. FordycePNAS April 17, 2018 115 (16) E3702-E3711; published ahead of print March 27, 2018. https://doi.org/10.1073/pnas.1715888115
- You have accessRobust, linear correlations between growth rates and β-lactam–mediated lysis ratesAnna J. Lee, Shangying Wang, Hannah R. Meredith, Bihan Zhuang, Zhuojun Dai, and Lingchong YouPNAS April 17, 2018 115 (16) 4069-4074; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719504115
- You have accessCell contraction induces long-ranged stress stiffening in the extracellular matrixYu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger D. Kamm, Martin Lenz, Chase P. Broedersz, and Ming GuoPNAS April 17, 2018 115 (16) 4075-4080; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1722619115
- Open AccessStructural dynamics is a determinant of the functional significance of missense variantsLuca Ponzoni and Ivet BaharPNAS April 17, 2018 115 (16) 4164-4169; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715896115
Chemistry
- You have accessMolecular excitonic seesawsPhilipp Wilhelm, Jakob Schedlbauer, Florian Hinderer, Daniel Hennen, Sigurd Höger, Jan Vogelsang, and John M. LuptonPNAS April 17, 2018 115 (16) E3626-E3634; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1722229115
- Open AccessLabel-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scalesOrly B. Tarun, Christof Hannesschläger, Peter Pohl, and Sylvie RokePNAS April 17, 2018 115 (16) 4081-4086; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719347115
- Open AccessDirect electrochemical observation of glucosidase activity in isolated single lysosomes from a living cellRongrong Pan, Mingchen Xu, James D. Burgess, Dechen Jiang, and Hong-Yuan ChenPNAS April 17, 2018 115 (16) 4087-4092; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719844115
- You have accessPrecise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talkIoanna Ntai, Luca Fornelli, Caroline J. DeHart, Josiah E. Hutton, Peter F. Doubleday, Richard D. LeDuc, Alexandra J. van Nispen, Ryan T. Fellers, Gordon Whiteley, Emily S. Boja, Henry Rodriguez, and Neil L. KelleherPNAS April 17, 2018 115 (16) 4140-4145; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1716122115
Computer Sciences
- You have accessWord embeddings quantify 100 years of gender and ethnic stereotypesNikhil Garg, Londa Schiebinger, Dan Jurafsky, and James ZouPNAS April 17, 2018 115 (16) E3635-E3644; published ahead of print April 3, 2018. https://doi.org/10.1073/pnas.1720347115
- You have accessCharacterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histologyDaniel H. Adler, Laura E. M. Wisse, Ranjit Ittyerah, John B. Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L. Robinson, Theresa Schuck, John Q. Trojanowski, Murray Grossman, John A. Detre, Mark A. Elliott, Jon B. Toledo, Weixia Liu, Stephen Pickup, Michael I. Miller, Sandhitsu R. Das, David A. Wolk, and Paul A. YushkevichPNAS April 17, 2018 115 (16) 4252-4257; published ahead of print March 28, 2018. https://doi.org/10.1073/pnas.1801093115
Earth, Atmospheric, and Planetary Sciences
- Open AccessCritical impact of vegetation physiology on the continental hydrologic cycle in response to increasing CO2Léo Lemordant, Pierre Gentine, Abigail S. Swann, Benjamin I. Cook, and Jacob ScheffPNAS April 17, 2018 115 (16) 4093-4098; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720712115
- You have accessEffects of iron on the lattice thermal conductivity of Earth’s deep mantle and implications for mantle dynamicsWen-Pin Hsieh, Frédéric Deschamps, Takuo Okuchi, and Jung-Fu LinPNAS April 17, 2018 115 (16) 4099-4104; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718557115
- Open AccessConstraining the climate and ocean pH of the early Earth with a geological carbon cycle modelJoshua Krissansen-Totton, Giada N. Arney, and David C. CatlingPNAS April 17, 2018 115 (16) 4105-4110; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1721296115
- You have accessEnergetic tradeoffs control the size distribution of aquatic mammals
- From the Cover
William Gearty, Craig R. McClain, and Jonathan L. PaynePNAS April 17, 2018 115 (16) 4194-4199; published ahead of print March 26, 2018. https://doi.org/10.1073/pnas.1712629115
Physics
- Open AccessFluctuations uncover a distinct class of traveling wavesGabriel Birzu, Oskar Hallatschek, and Kirill S. KorolevPNAS April 17, 2018 115 (16) E3645-E3654; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715737115
- You have accessSoft self-assembly of Weyl materials for light and soundMichel Fruchart, Seung-Yeol Jeon, Kahyun Hur, Vadim Cheianov, Ulrich Wiesner, and Vincenzo VitelliPNAS April 17, 2018 115 (16) E3655-E3664; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720828115
- You have accessTopological order in the pseudogap metalMathias S. Scheurer, Shubhayu Chatterjee, Wei Wu, Michel Ferrero, Antoine Georges, and Subir SachdevPNAS April 17, 2018 115 (16) E3665-E3672; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720580115
- Open AccessMechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasisSandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, and Cecilia M. SahlgrenPNAS April 17, 2018 115 (16) E3682-E3691; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715277115
Sustainability Science
- You have accessCarbon pools in China’s terrestrial ecosystems: New estimates based on an intensive field surveyXuli Tang, Xia Zhao, Yongfei Bai, Zhiyao Tang, Wantong Wang, Yongcun Zhao, Hongwei Wan, Zongqiang Xie, Xuezheng Shi, Bingfang Wu, Gengxu Wang, Junhua Yan, Keping Ma, Sheng Du, Shenggong Li, Shijie Han, Youxin Ma, Huifeng Hu, Nianpeng He, Yuanhe Yang, Wenxuan Han, Hongling He, Guirui Yu, Jingyun Fang, and Guoyi Zhou
- You have accessPatterns of plant carbon, nitrogen, and phosphorus concentration in relation to productivity in China’s terrestrial ecosystemsZhiyao Tang, Wenting Xu, Guoyi Zhou, Yongfei Bai, Jiaxiang Li, Xuli Tang, Dima Chen, Qing Liu, Wenhong Ma, Gaoming Xiong, Honglin He, Nianpeng He, Yanpei Guo, Qiang Guo, Jiangling Zhu, Wenxuan Han, Huifeng Hu, Jingyun Fang, and Zongqiang XiePNAS April 17, 2018 115 (16) 4033-4038; published ahead of print April 16, 2018. https://doi.org/10.1073/pnas.1700295114
- You have accessShifting plant species composition in response to climate change stabilizes grassland primary productionHuiying Liu, Zhaorong Mi, Li Lin, Yonghui Wang, Zhenhua Zhang, Fawei Zhang, Hao Wang, Lingli Liu, Biao Zhu, Guangmin Cao, Xinquan Zhao, Nathan J. Sanders, Aimée T. Classen, Peter B. Reich, and Jin-Sheng He
- Open AccessChina, the United States, and competition for resources that enable emerging technologiesAndrew L. Gulley, Nedal T. Nassar, and Sean XunPNAS April 17, 2018 115 (16) 4111-4115; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1717152115
Social Sciences
Anthropology
- You have accessOrigins and spread of fluted-point technology in the Canadian Ice-Free Corridor and eastern BeringiaHeather L. Smith and Ted GoebelPNAS April 17, 2018 115 (16) 4116-4121; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1800312115
Psychological and Cognitive Sciences
- Open AccessThe computational form of craving is a selective multiplication of economic valueAnna B. Konova, Kenway Louie, and Paul W. GlimcherPNAS April 17, 2018 115 (16) 4122-4127; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1714443115
Social Sciences
- You have accessWord embeddings quantify 100 years of gender and ethnic stereotypesNikhil Garg, Londa Schiebinger, Dan Jurafsky, and James ZouPNAS April 17, 2018 115 (16) E3635-E3644; published ahead of print April 3, 2018. https://doi.org/10.1073/pnas.1720347115
Sustainability Science
- Open AccessChina, the United States, and competition for resources that enable emerging technologiesAndrew L. Gulley, Nedal T. Nassar, and Sean XunPNAS April 17, 2018 115 (16) 4111-4115; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1717152115
Biological Sciences
Anthropology
- Open AccessHuman bony labyrinth is an indicator of population history and dispersal from Africa
- From the Cover
Marcia S. Ponce de León, Toetik Koesbardiati, John David Weissmann, Marco Milella, Carlos S. Reyna-Blanco, Gen Suwa, Osamu Kondo, Anna-Sapfo Malaspinas, Tim D. White, and Christoph P. E. ZollikoferPNAS April 17, 2018 115 (16) 4128-4133; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1717873115 - Open AccessHip extensor mechanics and the evolution of walking and climbing capabilities in humans, apes, and fossil homininsElaine E. Kozma, Nicole M. Webb, William E. H. Harcourt-Smith, David A. Raichlen, Kristiaan D'Août, Mary H. Brown, Emma M. Finestone, Stephen R. Ross, Peter Aerts, and Herman PontzerPNAS April 17, 2018 115 (16) 4134-4139; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715120115
Biochemistry
- You have accessPharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasisLinjie Zhao, Shuang Huang, Shenglin Mei, Zhengnan Yang, Lian Xu, Nianxin Zhou, Qilian Yang, Qiuhong Shen, Wei Wang, Xiaobing Le, Wayne Bond Lau, Bonnie Lau, Xin Wang, Tao Yi, Xia Zhao, Yuquan Wei, Margaret Warner, Jan-Åke Gustafsson, and Shengtao ZhouPNAS April 17, 2018 115 (16) E3673-E3681; published ahead of print March 28, 2018. https://doi.org/10.1073/pnas.1803291115
- You have accessPrecise characterization of KRAS4b proteoforms in human colorectal cells and tumors reveals mutation/modification cross-talkIoanna Ntai, Luca Fornelli, Caroline J. DeHart, Josiah E. Hutton, Peter F. Doubleday, Richard D. LeDuc, Alexandra J. van Nispen, Ryan T. Fellers, Gordon Whiteley, Emily S. Boja, Henry Rodriguez, and Neil L. KelleherPNAS April 17, 2018 115 (16) 4140-4145; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1716122115
- You have accessOversized galactosides as a probe for conformational dynamics in LacYIrina Smirnova, Vladimir Kasho, Xiaoxu Jiang, Hong-Ming Chen, Stephen G. Withers, and H. Ronald KabackPNAS April 17, 2018 115 (16) 4146-4151; published ahead of print March 30, 2018. https://doi.org/10.1073/pnas.1800706115
- You have accessObservation of acetyl phosphate formation in mammalian mitochondria using real-time in-organelle NMR metabolomicsWen Jun Xu, He Wen, Han Sun Kim, Yoon-Joo Ko, Seung-Mo Dong, In-Sun Park, Jong In Yook, and Sunghyouk ParkPNAS April 17, 2018 115 (16) 4152-4157; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720908115
- Open AccessMolecular structural diversity of mitochondrial cardiolipinsGregor Oemer, Katharina Lackner, Katharina Muigg, Gerhard Krumschnabel, Katrin Watschinger, Sabrina Sailer, Herbert Lindner, Erich Gnaiger, Saskia B. Wortmann, Ernst R. Werner, Johannes Zschocke, and Markus A. KellerPNAS April 17, 2018 115 (16) 4158-4163; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1719407115
Biophysics and Computational Biology
- You have accessRoll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D mediaAlejandro Bilbao, Amar K. Patel, Mizanur Rahman, Siva A. Vanapalli, and Jerzy BlawzdziewiczPNAS April 17, 2018 115 (16) E3616-E3625; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1706754115
- Open AccessMechanosensitivity of Jagged–Notch signaling can induce a switch-type behavior in vascular homeostasisSandra Loerakker, Oscar M. J. A. Stassen, Fleur M. ter Huurne, Marcelo Boareto, Carlijn V. C. Bouten, and Cecilia M. SahlgrenPNAS April 17, 2018 115 (16) E3682-E3691; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715277115
- Open AccessAccurate and sensitive quantification of protein-DNA binding affinityChaitanya Rastogi, H. Tomas Rube, Judith F. Kribelbauer, Justin Crocker, Ryan E. Loker, Gabriella D. Martini, Oleg Laptenko, William A. Freed-Pastor, Carol Prives, David L. Stern, Richard S. Mann, and Harmen J. BussemakerPNAS April 17, 2018 115 (16) E3692-E3701; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1714376115
- Open AccessComprehensive, high-resolution binding energy landscapes reveal context dependencies of transcription factor bindingDaniel D. Le, Tyler C. Shimko, Arjun K. Aditham, Allison M. Keys, Scott A. Longwell, Yaron Orenstein, and Polly M. FordycePNAS April 17, 2018 115 (16) E3702-E3711; published ahead of print March 27, 2018. https://doi.org/10.1073/pnas.1715888115
- You have accessSpatial organization and dynamics of RNase E and ribosomes in Caulobacter crescentusCamille A. Bayas, Jiarui Wang, Marissa K. Lee, Jared M. Schrader, Lucy Shapiro, and W. E. MoernerPNAS April 17, 2018 115 (16) E3712-E3721; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1721648115
- You have accessCell contraction induces long-ranged stress stiffening in the extracellular matrixYu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger D. Kamm, Martin Lenz, Chase P. Broedersz, and Ming GuoPNAS April 17, 2018 115 (16) 4075-4080; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1722619115
- Open AccessLabel-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scalesOrly B. Tarun, Christof Hannesschläger, Peter Pohl, and Sylvie RokePNAS April 17, 2018 115 (16) 4081-4086; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719347115
- Open AccessStructural dynamics is a determinant of the functional significance of missense variantsLuca Ponzoni and Ivet BaharPNAS April 17, 2018 115 (16) 4164-4169; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715896115
- You have accessMicrobes vs. chemistry in the origin of the anaerobic gut lumenElliot S. Friedman, Kyle Bittinger, Tatiana V. Esipova, Likai Hou, Lillian Chau, Jack Jiang, Clementina Mesaros, Peder J. Lund, Xue Liang, Garret A. FitzGerald, Mark Goulian, Daeyeon Lee, Benjamin A. Garcia, Ian A. Blair, Sergei A. Vinogradov, and Gary D. WuPNAS April 17, 2018 115 (16) 4170-4175; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718635115
Cell Biology
- Open AccessInsight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideumMarc Edwards, Huaqing Cai, Bedri Abubaker-Sharif, Yu Long, Thomas J. Lampert, and Peter N. DevreotesPNAS April 17, 2018 115 (16) E3722-E3730; published ahead of print March 30, 2018. https://doi.org/10.1073/pnas.1710480115
- Open AccessDirect electrochemical observation of glucosidase activity in isolated single lysosomes from a living cellRongrong Pan, Mingchen Xu, James D. Burgess, Dechen Jiang, and Hong-Yuan ChenPNAS April 17, 2018 115 (16) 4087-4092; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719844115
- Open AccessIncreased autophagy blocks HER2-mediated breast tumorigenesisSilvia Vega-Rubín-de-Celis, Zhongju Zou, Álvaro F. Fernández, Bo Ci, Min Kim, Guanghua Xiao, Yang Xie, and Beth LevinePNAS April 17, 2018 115 (16) 4176-4181; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1717800115
- You have accessTWEAK and RIPK1 mediate a second wave of cell death during AKIDiego Martin-Sanchez, Miguel Fontecha-Barriuso, Susana Carrasco, Maria Dolores Sanchez-Niño, Anne von Mässenhausen, Andreas Linkermann, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz, and Ana Belen SanzPNAS April 17, 2018 115 (16) 4182-4187; published ahead of print March 27, 2018. https://doi.org/10.1073/pnas.1716578115
Developmental Biology
- You have accessEvolutionary emergence of the rac3b/rfng/sgca regulatory cluster refined mechanisms for hindbrain boundaries formationJoaquín Letelier, Javier Terriente, Ivan Belzunce, Adria Voltes, Cristian Alberto Undurraga, Rocio Polvillo, Lucie Devos, Juan J. Tena, Ignacio Maeso, Sylvie Retaux, José Luis Gomez-Skarmeta, Juan R. Martínez-Morales, and Cristina PujadesPNAS April 17, 2018 115 (16) E3731-E3740; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719885115
- Open AccessTransient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heartHéctor Sánchez-Iranzo, María Galardi-Castilla, Andrés Sanz-Morejón, Juan Manuel González-Rosa, Ricardo Costa, Alexander Ernst, Julio Sainz de Aja, Xavier Langa, and Nadia MercaderPNAS April 17, 2018 115 (16) 4188-4193; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1716713115
Ecology
- You have accessCarbon pools in China’s terrestrial ecosystems: New estimates based on an intensive field surveyXuli Tang, Xia Zhao, Yongfei Bai, Zhiyao Tang, Wantong Wang, Yongcun Zhao, Hongwei Wan, Zongqiang Xie, Xuezheng Shi, Bingfang Wu, Gengxu Wang, Junhua Yan, Keping Ma, Sheng Du, Shenggong Li, Shijie Han, Youxin Ma, Huifeng Hu, Nianpeng He, Yuanhe Yang, Wenxuan Han, Hongling He, Guirui Yu, Jingyun Fang, and Guoyi Zhou
- You have accessPlant diversity enhances productivity and soil carbon storageShiping Chen, Wantong Wang, Wenting Xu, Yang Wang, Hongwei Wan, Dima Chen, Zhiyao Tang, Xuli Tang, Guoyi Zhou, Zongqiang Xie, Daowei Zhou, Zhouping Shangguan, Jianhui Huang, Jin-Sheng He, Yanfen Wang, Jiandong Sheng, Lisong Tang, Xinrong Li, Ming Dong, Yan Wu, Qiufeng Wang, Zhiheng Wang, Jianguo Wu, F. Stuart Chapin III, and Yongfei Bai
- You have accessPatterns of plant carbon, nitrogen, and phosphorus concentration in relation to productivity in China’s terrestrial ecosystemsZhiyao Tang, Wenting Xu, Guoyi Zhou, Yongfei Bai, Jiaxiang Li, Xuli Tang, Dima Chen, Qing Liu, Wenhong Ma, Gaoming Xiong, Honglin He, Nianpeng He, Yanpei Guo, Qiang Guo, Jiangling Zhu, Wenxuan Han, Huifeng Hu, Jingyun Fang, and Zongqiang XiePNAS April 17, 2018 115 (16) 4033-4038; published ahead of print April 16, 2018. https://doi.org/10.1073/pnas.1700295114
- You have accessEffects of national ecological restoration projects on carbon sequestration in China from 2001 to 2010Fei Lu, Huifeng Hu, Wenjuan Sun, Jiaojun Zhu, Guobin Liu, Wangming Zhou, Quanfa Zhang, Peili Shi, Xiuping Liu, Xing Wu, Lu Zhang, Xiaohua Wei, Limin Dai, Kerong Zhang, Yirong Sun, Sha Xue, Wanjun Zhang, Dingpeng Xiong, Lei Deng, Bojie Liu, Li Zhou, Chao Zhang, Xiao Zheng, Jiansheng Cao, Yao Huang, Nianpeng He, Guoyi Zhou, Yongfei Bai, Zongqiang Xie, Zhiyao Tang, Bingfang Wu, Jingyun Fang, Guohua Liu, and Guirui Yu
- You have accessEconomics- and policy-driven organic carbon input enhancement dominates soil organic carbon accumulation in Chinese croplandsYongcun Zhao, Meiyan Wang, Shuijin Hu, Xudong Zhang, Zhu Ouyang, Ganlin Zhang, Biao Huang, Shiwei Zhao, Jinshui Wu, Deti Xie, Bo Zhu, Dongsheng Yu, Xianzhang Pan, Shengxiang Xu, and Xuezheng Shi
- You have accessShifting plant species composition in response to climate change stabilizes grassland primary productionHuiying Liu, Zhaorong Mi, Li Lin, Yonghui Wang, Zhenhua Zhang, Fawei Zhang, Hao Wang, Lingli Liu, Biao Zhu, Guangmin Cao, Xinquan Zhao, Nathan J. Sanders, Aimée T. Classen, Peter B. Reich, and Jin-Sheng He
Evolution
- Open AccessFluctuations uncover a distinct class of traveling wavesGabriel Birzu, Oskar Hallatschek, and Kirill S. KorolevPNAS April 17, 2018 115 (16) E3645-E3654; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1715737115
- You have accessEnergetic tradeoffs control the size distribution of aquatic mammals
- From the Cover
William Gearty, Craig R. McClain, and Jonathan L. PaynePNAS April 17, 2018 115 (16) 4194-4199; published ahead of print March 26, 2018. https://doi.org/10.1073/pnas.1712629115 - Open AccessImpact of the tree prior on estimating clock rates during epidemic outbreaksSimon Möller, Louis du Plessis, and Tanja StadlerPNAS April 17, 2018 115 (16) 4200-4205; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1713314115
Genetics
- You have accessAutochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylaseSamuel K. McBrayer, Benjamin A. Olenchock, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Rebecca B. Jennings, Jesse S. Novak, Matthew G. Oser, Alissa K. Robbins, Rebecca Modiste, Dennis Bonal, Javid Moslehi, Roderick T. Bronson, Donna Neuberg, Quang-De Nguyen, Sabina Signoretti, Julie-Aurore Losman, and William G. Kaelin Jr.PNAS April 17, 2018 115 (16) E3741-E3748; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1716029115
- Open AccessEverolimus rescues multiple cellular defects in laminopathy-patient fibroblastsAmanda J. DuBose, Stephen T. Lichtenstein, Noreen M. Petrash, Michael R. Erdos, Leslie B. Gordon, and Francis S. CollinsPNAS April 17, 2018 115 (16) 4206-4211; published ahead of print March 26, 2018. https://doi.org/10.1073/pnas.1802811115
- You have accessHigh-accuracy lagging-strand DNA replication mediated by DNA polymerase dissociationKatarzyna H. Maslowska, Karolina Makiela-Dzbenska, Jin-Yao Mo, Iwona J. Fijalkowska, and Roel M. SchaaperPNAS April 17, 2018 115 (16) 4212-4217; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720353115
- You have accessTranscriptional mutagenesis mediated by 8-oxoG induces translational errors in mammalian cellsDa-Peng Dai, Wei Gan, Hiroshi Hayakawa, Jia-Lou Zhu, Xiu-Qing Zhang, Guo-Xin Hu, Tao Xu, Zhe-Li Jiang, Li-Qun Zhang, Xue-Da Hu, Ben Nie, Yue Zhou, Jin Li, Xiao-Yang Zhou, Jian Li, Tie-Mei Zhang, Qing He, Dong-Ge Liu, Hai-Bo Chen, Nan Yang, Ping-Ping Zuo, Zhi-Xin Zhang, Huan-Ming Yang, Yao Wang, Samuel H. Wilson, Yi-Xin Zeng, Jian-Ye Wang, Mutsuo Sekiguchi, and Jian-Ping CaiPNAS April 17, 2018 115 (16) 4218-4222; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718363115
Medical Sciences
- You have accessInterrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasiaYi Fan, Weiqing Liu, Ruiye Bi, Michael J. Densmore, Tadatoshi Sato, Michael Mannstadt, Quan Yuan, Xuedong Zhou, Hannes Olauson, Tobias E. Larsson, Hakan R. Toka, Martin R. Pollak, Edward M. Brown, and Beate LanskePNAS April 17, 2018 115 (16) E3749-E3758; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1717754115
- You have accessFAM210A is a novel determinant of bone and muscle structure and strengthKen-ichiro Tanaka, Yingben Xue, Loan Nguyen-Yamamoto, John A. Morris, Ippei Kanazawa, Toshitsugu Sugimoto, Simon S. Wing, J. Brent Richards, and David GoltzmanPNAS April 17, 2018 115 (16) E3759-E3768; published ahead of print April 4, 2018. https://doi.org/10.1073/pnas.1719089115
- You have accessTargeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalkCarlos A. Orozco, Neus Martinez-Bosch, Pedro E. Guerrero, Judith Vinaixa, Tomás Dalotto-Moreno, Mar Iglesias, Mireia Moreno, Magdolna Djurec, Françoise Poirier, Hans-Joachim Gabius, Martin E. Fernandez-Zapico, Rosa F. Hwang, Carmen Guerra, Gabriel A. Rabinovich, and Pilar NavarroPNAS April 17, 2018 115 (16) E3769-E3778; published ahead of print April 3, 2018. https://doi.org/10.1073/pnas.1722434115
- Open AccessLearned immunosuppressive placebo responses in renal transplant patientsJulia Kirchhof, Liubov Petrakova, Alexandra Brinkhoff, Sven Benson, Justine Schmidt, Maike Unteroberdörster, Benjamin Wilde, Ted J. Kaptchuk, Oliver Witzke, and Manfred SchedlowskiPNAS April 17, 2018 115 (16) 4223-4227; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720548115
- You have accessAblation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesisHe Xu, Min-Sik Lee, Pei-Yun Tsai, Ashley S. Adler, Natasha L. Curry, Saketh Challa, Elizaveta Freinkman, Daniel S. Hitchcock, Kyle D. Copps, Morris F. White, Roderick T. Bronson, Michael Marcotrigiano, Yaotang Wu, Clary B. Clish, and Nada Y. KalaanyPNAS April 17, 2018 115 (16) 4228-4233; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718414115
- You have accessIntron retention induced by microsatellite expansions as a disease biomarkerŁukasz J. Sznajder, James D. Thomas, Ellie M. Carrell, Tammy Reid, Karen N. McFarland, John D. Cleary, Ruan Oliveira, Curtis A. Nutter, Kirti Bhatt, Krzysztof Sobczak, Tetsuo Ashizawa, Charles A. Thornton, Laura P. W. Ranum, and Maurice S. SwansonPNAS April 17, 2018 115 (16) 4234-4239; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1716617115
Microbiology
- You have accessThe Vibrio cholerae type VI secretion system can modulate host intestinal mechanics to displace gut bacterial symbiontsSavannah L. Logan, Jacob Thomas, Jinyuan Yan, Ryan P. Baker, Drew S. Shields, Joao B. Xavier, Brian K. Hammer, and Raghuveer ParthasarathyPNAS April 17, 2018 115 (16) E3779-E3787; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720133115
- You have accessPlasticity in early immune evasion strategies of a bacterial pathogenQuentin Bernard, Alexis A. Smith, Xiuli Yang, Juraj Koci, Shelby D. Foor, Sarah D. Cramer, Xuran Zhuang, Jennifer E. Dwyer, Yi-Pin Lin, Emmanuel F. Mongodin, Adriana Marques, John M. Leong, Juan Anguita, and Utpal PalPNAS April 17, 2018 115 (16) E3788-E3797; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718595115
- You have accessSAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathwaysShuliang Chen, Serena Bonifati, Zhihua Qin, Corine St. Gelais, Karthik M. Kodigepalli, Bradley S. Barrett, Sun Hee Kim, Jenna M. Antonucci, Katherine J. Ladner, Olga Buzovetsky, Kirsten M. Knecht, Yong Xiong, Jacob S. Yount, Denis C. Guttridge, Mario L. Santiago, and Li WuPNAS April 17, 2018 115 (16) E3798-E3807; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1801213115
- Open AccessMultiple nuclear-replicating viruses require the stress-induced protein ZC3H11A for efficient growthShady Younis, Wael Kamel, Tina Falkeborn, Hao Wang, Di Yu, Robert Daniels, Magnus Essand, Jorma Hinkula, Göran Akusjärvi, and Leif AnderssonPNAS April 17, 2018 115 (16) E3808-E3816; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1722333115
- You have accessA small-molecule fragment that emulates binding of receptor and broadly neutralizing antibodies to influenza A hemagglutininRameshwar U. Kadam and Ian A. WilsonPNAS April 17, 2018 115 (16) 4240-4245; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1801999115
- Open AccessFlavivirus internalization is regulated by a size-dependent endocytic pathwayBrent A. Hackett and Sara CherryPNAS April 17, 2018 115 (16) 4246-4251; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720032115
Neuroscience
- Open AccessSpatial eye–hand coordination during bimanual reaching is not systematically coded in either LIP or PRREric Mooshagian and Lawrence H. SnyderPNAS April 17, 2018 115 (16) E3817-E3826; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718267115
- You have accessIdentification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnoverSeok Heo, Graham H. Diering, Chan Hyun Na, Raja Sekhar Nirujogi, Julia L. Bachman, Akhilesh Pandey, and Richard L. HuganirPNAS April 17, 2018 115 (16) E3827-E3836; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720956115
- You have accessCharacterizing the human hippocampus in aging and Alzheimer’s disease using a computational atlas derived from ex vivo MRI and histologyDaniel H. Adler, Laura E. M. Wisse, Ranjit Ittyerah, John B. Pluta, Song-Lin Ding, Long Xie, Jiancong Wang, Salmon Kadivar, John L. Robinson, Theresa Schuck, John Q. Trojanowski, Murray Grossman, John A. Detre, Mark A. Elliott, Jon B. Toledo, Weixia Liu, Stephen Pickup, Michael I. Miller, Sandhitsu R. Das, David A. Wolk, and Paul A. YushkevichPNAS April 17, 2018 115 (16) 4252-4257; published ahead of print March 28, 2018. https://doi.org/10.1073/pnas.1801093115
- You have accessSecond-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeysChia-Chi Liao, Jamie L. Reed, Hui-Xin Qi, Eva K. Sawyer, and Jon H. KaasPNAS April 17, 2018 115 (16) 4258-4263; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1718826115
- You have accessPsychophysical evidence for auditory motion parallax
- From the Cover
Daria Genzel, Michael Schutte, W. Owen Brimijoin, Paul R. MacNeilage, and Lutz WiegrebePNAS April 17, 2018 115 (16) 4264-4269; published ahead of print March 12, 2018. https://doi.org/10.1073/pnas.1712058115 - Open AccessEctopic neurogenesis induced by prenatal antiepileptic drug exposure augments seizure susceptibility in adult miceAtsuhiko Sakai, Taito Matsuda, Hiroyoshi Doi, Yukiko Nagaishi, Kiyoko Kato, and Kinichi NakashimaPNAS April 17, 2018 115 (16) 4270-4275; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1716479115
- You have accessLong-term in vivo recording of circadian rhythms in brains of freely moving miceLong Mei, Yanyan Fan, Xiaohua Lv, David K. Welsh, Cheng Zhan, and Eric Erquan ZhangPNAS April 17, 2018 115 (16) 4276-4281; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1717735115
Pharmacology
- Open AccessActivation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawalJulia K. Brynildsen, Bridgin G. Lee, Isaac J. Perron, Sunghee Jin, Sangwon F. Kim, and Julie A. BlendyPNAS April 17, 2018 115 (16) 4282-4287; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1707047115
Plant Biology
- You have accessNegative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repairLili Wang, Hanchen Chen, Chongyang Wang, Zhenjie Hu, and Shunping YanPNAS April 17, 2018 115 (16) E3837-E3845; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1720094115
- Open AccessPhytophthora palmivora establishes tissue-specific intracellular infection structures in the earliest divergent land plant lineagePhilip Carella, Anna Gogleva, Marta Tomaselli, Carolin Alfs, and Sebastian SchornackPNAS April 17, 2018 115 (16) E3846-E3855; published ahead of print April 3, 2018. https://doi.org/10.1073/pnas.1717900115
Sustainability Science
- You have accessEffects of national ecological restoration projects on carbon sequestration in China from 2001 to 2010Fei Lu, Huifeng Hu, Wenjuan Sun, Jiaojun Zhu, Guobin Liu, Wangming Zhou, Quanfa Zhang, Peili Shi, Xiuping Liu, Xing Wu, Lu Zhang, Xiaohua Wei, Limin Dai, Kerong Zhang, Yirong Sun, Sha Xue, Wanjun Zhang, Dingpeng Xiong, Lei Deng, Bojie Liu, Li Zhou, Chao Zhang, Xiao Zheng, Jiansheng Cao, Yao Huang, Nianpeng He, Guoyi Zhou, Yongfei Bai, Zongqiang Xie, Zhiyao Tang, Bingfang Wu, Jingyun Fang, Guohua Liu, and Guirui Yu
Systems Biology
- You have accessRobust, linear correlations between growth rates and β-lactam–mediated lysis ratesAnna J. Lee, Shangying Wang, Hannah R. Meredith, Bihan Zhuang, Zhuojun Dai, and Lingchong YouPNAS April 17, 2018 115 (16) 4069-4074; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1719504115
- You have accessRole of metabolic spatiotemporal dynamics in regulating biofilm colony expansionFederico Bocci, Yoko Suzuki, Mingyang Lu, and José N. OnuchicPNAS April 17, 2018 115 (16) 4288-4293; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1706920115
Corrections (Online Only)
- You have accessCorrection for Ramus et al,. An invasive foundation species enhances multifunctionality in a coastal ecosystemPNAS April 17, 2018 115 (16) E3856; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1804651115
- You have accessCorrection for Chen et al., B7-H1 maintains the polyclonal T cell response by protecting dendritic cells from cytotoxic T lymphocyte destructionPNAS April 17, 2018 115 (16) E3857; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1804362115
- You have accessCorrection for Li et al., Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overloadPNAS April 17, 2018 115 (16) E3858-E3861; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1804573115
- You have accessCorrection for Itkin et al., The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenoriiPNAS April 17, 2018 115 (16) E3862; published ahead of print April 2, 2018. https://doi.org/10.1073/pnas.1804875115
Commentaries