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Research Article

β-Amyloid accumulation in the human brain after one night of sleep deprivation

View ORCID ProfileEhsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste, and Nora D. Volkow
  1. aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
  2. bPiramal Pharma Inc., Boston, MA 02108;
  3. cDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT 06510

See allHide authors and affiliations

PNAS April 24, 2018 115 (17) 4483-4488; first published April 9, 2018; https://doi.org/10.1073/pnas.1721694115
Ehsan Shokri-Kojori
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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  • ORCID record for Ehsan Shokri-Kojori
  • For correspondence: ehsan.shokrikojori@nih.gov gene-jack.wang@nih.gov nvolkow@nida.nih.gov
Gene-Jack Wang
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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  • For correspondence: ehsan.shokrikojori@nih.gov gene-jack.wang@nih.gov nvolkow@nida.nih.gov
Corinde E. Wiers
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Sukru B. Demiral
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Min Guo
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Sung Won Kim
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Elsa Lindgren
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Veronica Ramirez
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Amna Zehra
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Clara Freeman
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Gregg Miller
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Peter Manza
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Tansha Srivastava
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Susan De Santi
bPiramal Pharma Inc., Boston, MA 02108;
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Dardo Tomasi
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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Helene Benveniste
cDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT 06510
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Nora D. Volkow
aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
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  • For correspondence: ehsan.shokrikojori@nih.gov gene-jack.wang@nih.gov nvolkow@nida.nih.gov
  1. Edited by Michael E. Phelps, University of California, Los Angeles, CA, and approved March 13, 2018 (received for review December 14, 2017)

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Article Information

vol. 115 no. 17 4483-4488
DOI: 
https://doi.org/10.1073/pnas.1721694115
PubMed: 
29632177

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue April 24, 2018.
  • Published first April 9, 2018.

Article Versions

  • Previous version (April 9, 2018 - 11:43).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Ehsan Shokri-Kojoria,1,
  2. Gene-Jack Wanga,1,
  3. Corinde E. Wiersa,
  4. Sukru B. Demirala,
  5. Min Guoa,
  6. Sung Won Kima,
  7. Elsa Lindgrena,
  8. Veronica Ramireza,
  9. Amna Zehraa,
  10. Clara Freemana,
  11. Gregg Millera,
  12. Peter Manzaa,
  13. Tansha Srivastavaa,
  14. Susan De Santib,
  15. Dardo Tomasia,
  16. Helene Benvenistec, and
  17. Nora D. Volkowa,1
  1. aLaboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892;
  2. bPiramal Pharma Inc., Boston, MA 02108;
  3. cDepartment of Anesthesiology, Yale School of Medicine, New Haven, CT 06510
  1. Edited by Michael E. Phelps, University of California, Los Angeles, CA, and approved March 13, 2018 (received for review December 14, 2017)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: ehsan.shokrikojori{at}nih.gov, gene-jack.wang{at}nih.gov, or nvolkow{at}nida.nih.gov.
  • Author contributions: N.D.V. conceived study; E.S.-K., G.-J.W., C.E.W., S.B.D., S.W.K., S.D.S., D.T., H.B., and N.D.V. designed research; E.S.-K., G.-J.W., C.E.W., S.B.D., M.G., S.W.K., E.L., V.R., A.Z., C.F., G.M., P.M., T.S., S.D.S., D.T., H.B., and N.D.V. performed research; E.S.-K. analyzed data; and E.S.-K. and N.D.V. wrote the paper.

  • Conflict of interest statement: S.D.S. was an employee of Piramal Pharma Inc., which partly supported the radiotracer for this study.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1721694115/-/DCSupplemental.

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Article usage

Article usage: April 2018 to April 2021

AbstractFullPdf
Apr 2018366544779314046
May 201815407161922353
Jun 201875817261755
Jul 201845934058585
Aug 2018270426661996
Sep 201827722850759
Oct 20183342830515
Nov 2018793859459
Dec 20181122074423
Total 2018702368958321891
Jan 20191063823420
Feb 2019971945522
Mar 20192072002456
Apr 20191641680345
May 20194291523300
Jun 2019811085202
Jul 20192261021234
Aug 20191271022199
Sep 2019119992193
Oct 20191301589338
Nov 20191841453373
Dec 20191181212264
Total 20191988193473846
Jan 2020801283296
Feb 20201131374375
Mar 20201021175246
Apr 2020104994367
May 2020861034332
Jun 202057655244
Jul 202063877220
Aug 2020120742258
Sep 20201521775439
Oct 20202183764477
Nov 20202921428337
Dec 20201831112237
Total 20201570162133828
Jan 20211421704505
Feb 20211441046316
Mar 20211471430333
Apr 20211081142233
Total 202154153221387
Total7433513046530952
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β-Amyloid accumulation in the human brain after one night of sleep deprivation
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β-Amyloid accumulation in the human brain after one night of sleep deprivation
Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste, Nora D. Volkow
Proceedings of the National Academy of Sciences Apr 2018, 115 (17) 4483-4488; DOI: 10.1073/pnas.1721694115

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β-Amyloid accumulation in the human brain after one night of sleep deprivation
Ehsan Shokri-Kojori, Gene-Jack Wang, Corinde E. Wiers, Sukru B. Demiral, Min Guo, Sung Won Kim, Elsa Lindgren, Veronica Ramirez, Amna Zehra, Clara Freeman, Gregg Miller, Peter Manza, Tansha Srivastava, Susan De Santi, Dardo Tomasi, Helene Benveniste, Nora D. Volkow
Proceedings of the National Academy of Sciences Apr 2018, 115 (17) 4483-4488; DOI: 10.1073/pnas.1721694115
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Proceedings of the National Academy of Sciences: 115 (17)
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