Proceedings of the National Academy of Sciences: 115 (2)

New Research In

January 09, 2018; vol. 115 no. 2

This Week in PNAS

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In This Issue
PNAS January 9, 2018 115 (2) 229-230; https://doi.org/10.1073/iti0218115

Letters (Online Only)

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Climate change and agricultural suicides in India
Kamal Kumar Murari, T. Jayaraman, and Madhura Swaminathan

PNAS January 9, 2018 115 (2) E115; first published December 29, 2017. https://doi.org/10.1073/pnas.1714747115
See companion article:
Flawed linking of temperature and suicide
- Dec 29, 2017

Analyzing Indian farmer suicide rates
- Dec 29, 2017
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Unfounded assumptions in linking crop-damaging temperature and suicide in India
Saudamini Das

PNAS January 9, 2018 115 (2) E116; first published December 29, 2017. https://doi.org/10.1073/pnas.1715331115
See companion article:
Climate change and agricultural suicides in India
- Dec 29, 2017

Analyzing Indian farmer suicide rates
- Dec 29, 2017
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Analyzing Indian farmer suicide rates
Ian Plewis

PNAS January 9, 2018 115 (2) E117; first published December 29, 2017. https://doi.org/10.1073/pnas.1714927115
See companion article:
Climate change and agricultural suicides in India
- Dec 29, 2017

Flawed linking of temperature and suicide
- Dec 29, 2017
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Reply to Plewis, Murari et al., and Das: The suicide–temperature link in India and the evidence of an agricultural channel are robust
Tamma A. Carleton

PNAS January 9, 2018 115 (2) E118-E121; first published December 29, 2017. https://doi.org/10.1073/pnas.1715454115
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Crop-damaging temperatures raise suicide in India
- Jul 31, 2017
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Note on bias from averaging repeated measurements in heritability studies
Benjamin B. Risk and Hongtu Zhu

PNAS January 9, 2018 115 (2) E122; first published December 29, 2017. https://doi.org/10.1073/pnas.1719250115
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Reply to Risk and Zhu: Mixed-effects modeling as a principled approach to heritability analysis with repeat measurements
Tian Ge, Avram J. Holmes, Randy L. Buckner, Jordan W. Smoller, and Mert R. Sabuncu

PNAS January 9, 2018 115 (2) E123; first published December 29, 2017. https://doi.org/10.1073/pnas.1719882115
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Heritability analysis with repeat measurements
- May 08, 2017

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Fishing for artifacts beneath the waves
Front Matter
Traci Watson

PNAS January 9, 2018 115 (2) 231-233; https://doi.org/10.1073/pnas.1720823115

Commentaries

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Fraternal birth order effect on sexual orientation explained
Jacques Balthazart

PNAS January 9, 2018 115 (2) 234-236; first published December 19, 2017. https://doi.org/10.1073/pnas.1719534115
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Male homosexuality and maternal immune responses
- Dec 11, 2017
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Replication fork convergence at termination: A multistep process
Nina Y. Yao and Mike E. O’Donnell

PNAS January 9, 2018 115 (2) 237-239; first published December 19, 2017. https://doi.org/10.1073/pnas.1719825115
See companion article:
SbcCD ExoI process convergent forks for completion
- Dec 05, 2017

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS January 9, 2018 115 (2) 240-244; https://doi.org/10.1073/pnas.ss1152

Perspective

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Two types of aggression in human evolution
From the Cover
Richard W. Wrangham

PNAS January 9, 2018 115 (2) 245-253; first published December 26, 2017. https://doi.org/10.1073/pnas.1713611115
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Partitioning aggression
- Jan 11, 2018

Physical Sciences

Applied Mathematics
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  A mixed-scale dense convolutional neural network for image analysis
  Daniël M. Pelt and James A. Sethian
  
  PNAS January 9, 2018 115 (2) 254-259; first published December 26, 2017. https://doi.org/10.1073/pnas.1715832114
Applied Physical Sciences
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  Interplay of structure, elasticity, and dynamics in actin-based nematic materials
  Rui Zhang, Nitin Kumar, Jennifer L. Ross, Margaret L. Gardel, and Juan J. de Pablo
  
  PNAS January 9, 2018 115 (2) E124-E133; first published December 28, 2017. https://doi.org/10.1073/pnas.1713832115
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  Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation
  Yun Zhang, Yongzhi Qiu, Aaron T. Blanchard, Yuan Chang, Josh M. Brockman, Victor Pui-Yan Ma, Wilbur A. Lam, and Khalid Salaita
  
  PNAS January 9, 2018 115 (2) 325-330; first published December 21, 2017. https://doi.org/10.1073/pnas.1710828115
Astronomy
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  Atmospheric escape from the TRAPPIST-1 planets and implications for habitability
  Chuanfei Dong, Meng Jin, Manasvi Lingam, Vladimir S. Airapetian, Yingjuan Ma, and Bart van der Holst
  
  PNAS January 9, 2018 115 (2) 260-265; first published December 28, 2017. https://doi.org/10.1073/pnas.1708010115
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  LAMOST telescope reveals that Neptunian cousins of hot Jupiters are mostly single offspring of stars that are rich in heavy elements
  From the Cover
  
  Subo Dong, Ji-Wei Xie, Ji-Lin Zhou, Zheng Zheng, and Ali Luo
  
  PNAS January 9, 2018 115 (2) 266-271; first published December 28, 2017. https://doi.org/10.1073/pnas.1711406115
Biophysics and Computational Biology
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  Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells
  Colin H. Lipper, Ola Karmi, Yang Sung Sohn, Merav Darash-Yahana, Heiko Lammert, Luhua Song, Amy Liu, Ron Mittler, Rachel Nechushtai, José N. Onuchic, and Patricia A. Jennings
  
  PNAS January 9, 2018 115 (2) 272-277; first published December 19, 2017. https://doi.org/10.1073/pnas.1715842115
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  A growing microcolony can survive and support persistent propagation of virulent phages
  Rasmus Skytte Eriksen, Sine L. Svenningsen, Kim Sneppen, and Namiko Mitarai
  
  PNAS January 9, 2018 115 (2) 337-342; first published December 19, 2017. https://doi.org/10.1073/pnas.1708954115
Chemistry
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  CO₂ reduction to acetate in mixtures of ultrasmall (Cu)_n,(Ag)_m bimetallic nanoparticles
  Ying Wang, Degao Wang, Christopher J. Dares, Seth L. Marquard, Matthew V. Sheridan, and Thomas J. Meyer
  
  PNAS January 9, 2018 115 (2) 278-283; first published December 26, 2017. https://doi.org/10.1073/pnas.1713962115
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  Low-lying excited states in crystalline perylene
  Tonatiuh Rangel, Andre Rinn, Sahar Sharifzadeh, Felipe H. da Jornada, André Pick, Steven G. Louie, Gregor Witte, Leeor Kronik, Jeffrey B. Neaton, and Sangam Chatterjee
  
  PNAS January 9, 2018 115 (2) 284-289; first published December 26, 2017. https://doi.org/10.1073/pnas.1711126115
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  Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch
  Heesoo Uhm, Wooyoung Kang, Kook Sun Ha, Changwon Kang, and Sungchul Hohng
  
  PNAS January 9, 2018 115 (2) 331-336; first published December 26, 2017. https://doi.org/10.1073/pnas.1712983115
Earth, Atmospheric, and Planetary Sciences
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  Causes and consequences of decreasing atmospheric organic aerosol in the United States
  D. A. Ridley, C. L. Heald, K. J. Ridley, and J. H. Kroll
  
  PNAS January 9, 2018 115 (2) 290-295; first published December 26, 2017. https://doi.org/10.1073/pnas.1700387115
Engineering
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  Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant
  Amit Kumar Sachan and Joseph A. Zasadzinski
  
  PNAS January 9, 2018 115 (2) E134-E143; first published December 26, 2017. https://doi.org/10.1073/pnas.1715830115
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  Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes
  Duo An, Alan Chiu, James A. Flanders, Wei Song, Dahua Shou, Yen-Chun Lu, Lars G. Grunnet, Louise Winkel, Camilla Ingvorsen, Nicolaj Strøyer Christophersen, Johannes Josef Fels, Fredrik Wolfhagen Sand, Yewei Ji, Ling Qi, Yehudah Pardo, Dan Luo, Meredith Silberstein, Jintu Fan, and Minglin Ma
  
  PNAS January 9, 2018 115 (2) E263-E272; first published December 26, 2017. https://doi.org/10.1073/pnas.1708806115
Environmental Sciences
- Open Access
  Impact of an historic underground gas well blowout on the current methane chemistry in a shallow groundwater system
  Gilian Schout, Niels Hartog, S. Majid Hassanizadeh, and Jasper Griffioen
  
  PNAS January 9, 2018 115 (2) 296-301; first published December 26, 2017. https://doi.org/10.1073/pnas.1711472115

Biological Sciences

Agricultural Sciences
- Open Access
  Inactivation of porcine interleukin-1β results in failure of rapid conceptus elongation
  Jeffrey J. Whyte, Ashley E. Meyer, Lee D. Spate, Joshua A. Benne, Raissa Cecil, Melissa S. Samuel, Clifton N. Murphy, Randall S. Prather, and Rodney D. Geisert
  
  PNAS January 9, 2018 115 (2) 307-312; first published December 26, 2017. https://doi.org/10.1073/pnas.1718004115
Biochemistry
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  Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae
  Michael S. Little, Samuel J. Pellock, William G. Walton, Ashutosh Tripathy, and Matthew R. Redinbo
  
  PNAS January 9, 2018 115 (2) E152-E161; first published December 21, 2017. https://doi.org/10.1073/pnas.1716241115
- Open Access
  Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA
  François Ferron, Lorenzo Subissi, Ana Theresa Silveira De Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, Gérard Bricogne, Bruno Canard, and Isabelle Imbert
  
  PNAS January 9, 2018 115 (2) E162-E171; first published December 26, 2017. https://doi.org/10.1073/pnas.1718806115
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  Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1
  Lucie A. Bergdoll, Michael T. Lerch, John W. Patrick, Kendrick Belardo, Christian Altenbach, Paola Bisignano, Arthur Laganowsky, Michael Grabe, Wayne L. Hubbell, and Jeff Abramson
  
  PNAS January 9, 2018 115 (2) E172-E179; first published December 26, 2017. https://doi.org/10.1073/pnas.1715464115
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  Structure of the human monomeric NEET protein MiNT and its role in regulating iron and reactive oxygen species in cancer cells
  Colin H. Lipper, Ola Karmi, Yang Sung Sohn, Merav Darash-Yahana, Heiko Lammert, Luhua Song, Amy Liu, Ron Mittler, Rachel Nechushtai, José N. Onuchic, and Patricia A. Jennings
  
  PNAS January 9, 2018 115 (2) 272-277; first published December 19, 2017. https://doi.org/10.1073/pnas.1715842115
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  High-resolution structure of podovirus tail adaptor suggests repositioning of an octad motif that mediates the sequential tail assembly
  Lingfei Liang, Haiyan Zhao, Bowen An, and Liang Tang
  
  PNAS January 9, 2018 115 (2) 313-318; first published December 26, 2017. https://doi.org/10.1073/pnas.1706846115
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  Structural basis of the phosphorylation-independent recognition of cyclin D1 by the SCF^FBXO31 ubiquitin ligase
  Yunfeng Li, Kai Jin, Eric Bunker, Xiaojuan Zhang, Xuemei Luo, Xuedong Liu, and Bing Hao
  
  PNAS January 9, 2018 115 (2) 319-324; first published December 26, 2017. https://doi.org/10.1073/pnas.1708677115
Biophysics and Computational Biology
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  Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation
  Yun Zhang, Yongzhi Qiu, Aaron T. Blanchard, Yuan Chang, Josh M. Brockman, Victor Pui-Yan Ma, Wilbur A. Lam, and Khalid Salaita
  
  PNAS January 9, 2018 115 (2) 325-330; first published December 21, 2017. https://doi.org/10.1073/pnas.1710828115
- You have access
  Single-molecule FRET studies on the cotranscriptional folding of a thiamine pyrophosphate riboswitch
  Heesoo Uhm, Wooyoung Kang, Kook Sun Ha, Changwon Kang, and Sungchul Hohng
  
  PNAS January 9, 2018 115 (2) 331-336; first published December 26, 2017. https://doi.org/10.1073/pnas.1712983115
- You have access
  A growing microcolony can survive and support persistent propagation of virulent phages
  Rasmus Skytte Eriksen, Sine L. Svenningsen, Kim Sneppen, and Namiko Mitarai
  
  PNAS January 9, 2018 115 (2) 337-342; first published December 19, 2017. https://doi.org/10.1073/pnas.1708954115
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  Visualizing long-term single-molecule dynamics in vivo by stochastic protein labeling
  Hui Liu, Peng Dong, Maria S. Ioannou, Li Li, Jamien Shea, H. Amalia Pasolli, Jonathan B. Grimm, Patricia K. Rivlin, Luke D. Lavis, Minoru Koyama, and Zhe Liu
  
  PNAS January 9, 2018 115 (2) 343-348; first published December 28, 2017. https://doi.org/10.1073/pnas.1713895115
Cell Biology
- Open Access
  Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy
  Christoph Potting, Christophe Crochemore, Francesca Moretti, Florian Nigsch, Isabel Schmidt, Carole Manneville, Walter Carbone, Judith Knehr, Rowena DeJesus, Alicia Lindeman, Rob Maher, Carsten Russ, Gregory McAllister, John S. Reece-Hoyes, Gregory R. Hoffman, Guglielmo Roma, Matthias Müller, Andreas W. Sailer, and Stephen B. Helliwell
  
  PNAS January 9, 2018 115 (2) E180-E189; first published December 21, 2017. https://doi.org/10.1073/pnas.1711023115
- Open Access
  RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases
  Geng-Xian Shi, Won Seok Yang, Ling Jin, Michelle L. Matter, and Joe W. Ramos
  
  PNAS January 9, 2018 115 (2) E190-E199; first published December 26, 2017. https://doi.org/10.1073/pnas.1708584115
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  Neuronal delivery of Hedgehog directs spatial patterning of taste organ regeneration
  Wan-Jin Lu, Randall K. Mann, Allison Nguyen, Tingting Bi, Max Silverstein, Jean Y. Tang, Xiaoke Chen, and Philip A. Beachy
  
  PNAS January 9, 2018 115 (2) E200-E209; first published December 26, 2017. https://doi.org/10.1073/pnas.1719109115
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  Listeria monocytogenes triggers noncanonical autophagy upon phagocytosis, but avoids subsequent growth-restricting xenophagy
  Gabriel Mitchell, Mandy I. Cheng, Chen Chen, Brittney N. Nguyen, Aaron T. Whiteley, Sara Kianian, Jeffery S. Cox, Douglas R. Green, Kent L. McDonald, and Daniel A. Portnoy
  
  PNAS January 9, 2018 115 (2) E210-E217; first published December 26, 2017. https://doi.org/10.1073/pnas.1716055115
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  SbcC-SbcD and ExoI process convergent forks to complete chromosome replication
  From the Cover
  
  Brian M. Wendel, Jessica M. Cole, Charmain T. Courcelle, and Justin Courcelle
  
  PNAS January 9, 2018 115 (2) 349-354; first published December 5, 2017. https://doi.org/10.1073/pnas.1715960114
  
  See companion article:
  Mechanism of replication termination
  - Dec 19, 2017
Developmental Biology
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  Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells
  Katherine E. Trevers, Ravindra S. Prajapati, Mark Hintze, Matthew J. Stower, Anna C. Strobl, Monica Tambalo, Ramya Ranganathan, Natalia Moncaut, Mohsin A. F. Khan, Claudio D. Stern, and Andrea Streit
  
  PNAS January 9, 2018 115 (2) 355-360; first published December 19, 2017. https://doi.org/10.1073/pnas.1719674115
Ecology
- Open Access
  Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes
  Lauren B. Carrington, Bich Chau Nguyen Tran, Nhat Thanh Hoang Le, Tai Thi Hue Luong, Truong Thanh Nguyen, Phong Thanh Nguyen, Chau Van Vinh Nguyen, Huong Thi Cam Nguyen, Trung Tuan Vu, Long Thi Vo, Dui Thi Le, Nhu Tuyet Vu, Giang Thi Nguyen, Hung Quoc Luu, Anh Duc Dang, Timothy P. Hurst, Scott L. O’Neill, Vi Thuy Tran, Duong Thi Hue Kien, Nguyet Minh Nguyen, Marcel Wolbers, Bridget Wills, and Cameron P. Simmons
  
  PNAS January 9, 2018 115 (2) 361-366; first published December 26, 2017. https://doi.org/10.1073/pnas.1715788115
Environmental Sciences
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  Control on rate and pathway of anaerobic organic carbon degradation in the seabed
  F. Beulig, H. Røy, C. Glombitza, and B. B. Jørgensen
  
  PNAS January 9, 2018 115 (2) 367-372; first published December 26, 2017. https://doi.org/10.1073/pnas.1715789115
Evolution
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  Hybrid speciation leads to novel male secondary sexual ornamentation of an Amazonian bird
  Alfredo O. Barrera-Guzmán, Alexandre Aleixo, Matthew D. Shawkey, and Jason T. Weir
  
  PNAS January 9, 2018 115 (2) E218-E225; first published December 26, 2017. https://doi.org/10.1073/pnas.1717319115
  
  See companion article:
  Reply to Rosenthal et al.: Both premating and postmating isolation likely contributed to manakin hybrid speciation
  - Apr 18, 2018
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  Multiple origins of interdependent endosymbiotic complexes in a genus of cicadas
  From the Cover
  
  Piotr Łukasik, Katherine Nazario, James T. Van Leuven, Matthew A. Campbell, Mariah Meyer, Anna Michalik, Pablo Pessacq, Chris Simon, Claudio Veloso, and John P. McCutcheon
  
  PNAS January 9, 2018 115 (2) E226-E235; first published December 26, 2017. https://doi.org/10.1073/pnas.1712321115
- Open Access
  Ancient polymorphisms and divergence hitchhiking contribute to genomic islands of divergence within a poplar species complex
  Tao Ma, Kun Wang, Quanjun Hu, Zhenxiang Xi, Dongshi Wan, Qian Wang, Jianju Feng, Dechun Jiang, Hamid Ahani, Richard J. Abbott, Martin Lascoux, Eviatar Nevo, and Jianquan Liu
  
  PNAS January 9, 2018 115 (2) E236-E243; first published December 26, 2017. https://doi.org/10.1073/pnas.1713288114
Genetics
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  Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia
  Bing Chen, Lu Jiang, Meng-Ling Zhong, Jian-Feng Li, Ben-Shang Li, Li-Jun Peng, Yu-Ting Dai, Bo-Wen Cui, Tian-Qi Yan, Wei-Na Zhang, Xiang-Qin Weng, Yin-Yin Xie, Jing Lu, Rui-Bao Ren, Su-Ning Chen, Jian-Da Hu, De-Pei Wu, Zhu Chen, Jing-Yan Tang, Jin-Yan Huang, Jian-Qing Mi, and Sai-Juan Chen
  
  PNAS January 9, 2018 115 (2) 373-378; first published December 26, 2017. https://doi.org/10.1073/pnas.1717125115
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  Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees
  Goo Jun, Alisa Manning, Marcio Almeida, Matthew Zawistowski, Andrew R. Wood, Tanya M. Teslovich, Christian Fuchsberger, Shuang Feng, Pablo Cingolani, Kyle J. Gaulton, Thomas Dyer, Thomas W. Blackwell, Han Chen, Peter S. Chines, Sungkyoung Choi, Claire Churchhouse, Pierre Fontanillas, Ryan King, SungYoung Lee, Stephen E. Lincoln, Vasily Trubetskoy, Mark DePristo, Tasha Fingerlin, Robert Grossman, Jason Grundstad, Alison Heath, Jayoun Kim, Young Jin Kim, Jason Laramie, Jaehoon Lee, Heng Li, Xuanyao Liu, Oren Livne, Adam E. Locke, Julian Maller, Alexander Mazur, Andrew P. Morris, Toni I. Pollin, Derek Ragona, David Reich, Manuel A. Rivas, Laura J. Scott, Xueling Sim, Rick G. Tearle, Yik Ying Teo, Amy L. Williams, Sebastian Zöllner, Joanne E. Curran, Juan Peralta, Beena Akolkar, Graeme I. Bell, Noël P. Burtt, Nancy J. Cox, Jose C. Florez, Craig L. Hanis, Catherine McKeon, Karen L. Mohlke, Mark Seielstad, James G. Wilson, Gil Atzmon, Jennifer E. Below, Josée Dupuis, Dan L. Nicolae, Donna Lehman, Taesung Park, Sungho Won, Robert Sladek, David Altshuler, Mark I. McCarthy, Ravindranath Duggirala, Michael Boehnke, Timothy M. Frayling, Gonçalo R. Abecasis, and John Blangero
  
  PNAS January 9, 2018 115 (2) 379-384; first published December 26, 2017. https://doi.org/10.1073/pnas.1705859115
Immunology and Inflammation
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  Histone demethylase LSD1 regulates hematopoietic stem cells homeostasis and protects from death by endotoxic shock
  Jianxun Wang, Kaoru Saijo, Dylan Skola, Chunyu Jin, Qi Ma, Daria Merkurjev, Christopher K. Glass, and Michael G. Rosenfeld
  
  PNAS January 9, 2018 115 (2) E244-E252; first published December 20, 2017. https://doi.org/10.1073/pnas.1718759114
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  FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes
  Ho-Keun Kwon, Hui-Min Chen, Diane Mathis, and Christophe Benoist
  
  PNAS January 9, 2018 115 (2) E253-E262; first published December 21, 2017. https://doi.org/10.1073/pnas.1718599115
- Open Access
  Male homosexuality and maternal immune responsivity to the Y-linked protein NLGN4Y
  Anthony F. Bogaert, Malvina N. Skorska, Chao Wang, José Gabrie, Adam J. MacNeil, Mark R. Hoffarth, Doug P. VanderLaan, Kenneth J. Zucker, and Ray Blanchard
  
  PNAS January 9, 2018 115 (2) 302-306; first published December 11, 2017. https://doi.org/10.1073/pnas.1705895114
  
  See companion article:
  Fraternal birth order and sexual orientation
  - Dec 19, 2017
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  Mixed signature of activation and dysfunction allows human decidual CD8⁺ T cells to provide both tolerance and immunity
  Anita van der Zwan, Kevin Bi, Errol R. Norwitz, Ângela C. Crespo, Frans H. J. Claas, Jack L. Strominger, and Tamara Tilburgs
  
  PNAS January 9, 2018 115 (2) 385-390; first published December 19, 2017. https://doi.org/10.1073/pnas.1713957115
Medical Sciences
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  Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes
  Duo An, Alan Chiu, James A. Flanders, Wei Song, Dahua Shou, Yen-Chun Lu, Lars G. Grunnet, Louise Winkel, Camilla Ingvorsen, Nicolaj Strøyer Christophersen, Johannes Josef Fels, Fredrik Wolfhagen Sand, Yewei Ji, Ling Qi, Yehudah Pardo, Dan Luo, Meredith Silberstein, Jintu Fan, and Minglin Ma
  
  PNAS January 9, 2018 115 (2) E263-E272; first published December 26, 2017. https://doi.org/10.1073/pnas.1708806115
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  Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia
  Leandro R. Soria, Gabriella Allegri, Dominique Melck, Nunzia Pastore, Patrizia Annunziata, Debora Paris, Elena Polishchuk, Edoardo Nusco, Beat Thöny, Andrea Motta, Johannes Häberle, Andrea Ballabio, and Nicola Brunetti-Pierri
  
  PNAS January 9, 2018 115 (2) 391-396; first published December 26, 2017. https://doi.org/10.1073/pnas.1714670115
Microbiology
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  Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria
  Changhan Lee, Kamila B. Franke, Shady Mansour Kamal, Hyunhee Kim, Heinrich Lünsdorf, Jasmin Jäger, Manfred Nimtz, Janja Trček, Lothar Jänsch, Bernd Bukau, Axel Mogk, and Ute Römling
  
  PNAS January 9, 2018 115 (2) E273-E282; first published December 20, 2017. https://doi.org/10.1073/pnas.1712051115
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  Colorectal cancer specific conditions promote Streptococcus gallolyticus gut colonization
  Laetitia Aymeric, Françoise Donnadieu, Céline Mulet, Laurence du Merle, Giulia Nigro, Azadeh Saffarian, Marion Bérard, Claire Poyart, Sylvie Robine, Béatrice Regnault, Patrick Trieu-Cuot, Philippe J. Sansonetti, and Shaynoor Dramsi
  
  PNAS January 9, 2018 115 (2) E283-E291; first published December 26, 2017. https://doi.org/10.1073/pnas.1715112115
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  Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus
  Jim Baggen, Daniel L. Hurdiss, Georg Zocher, Nitesh Mistry, Richard W. Roberts, Jasper J. Slager, Hongbo Guo, Arno L. W. van Vliet, Maryam Wahedi, Kimberley Benschop, Erwin Duizer, Cornelis A. M. de Haan, Erik de Vries, José M. Casasnovas, Raoul J. de Groot, Niklas Arnberg, Thilo Stehle, Neil A. Ranson, Hendrik Jan Thibaut, and Frank J. M. van Kuppeveld
  
  PNAS January 9, 2018 115 (2) 397-402; first published December 28, 2017. https://doi.org/10.1073/pnas.1713284115
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  Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR
  Yong-Liang Jiang, Xue-Ping Wang, Hui Sun, Shu-Jing Han, Wei-Fang Li, Ning Cui, Gui-Ming Lin, Ju-Yuan Zhang, Wang Cheng, Dong-Dong Cao, Zhi-Yong Zhang, Cheng-Cai Zhang, Yuxing Chen, and Cong-Zhao Zhou
  
  PNAS January 9, 2018 115 (2) 403-408; first published December 26, 2017. https://doi.org/10.1073/pnas.1716062115
Neuroscience
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  ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations
  Aifang Cheng, Teng Zhao, Kai-Hei Tse, Hei-Man Chow, Yong Cui, Liwen Jiang, Shengwang Du, Michael M. T. Loy, and Karl Herrup
  
  PNAS January 9, 2018 115 (2) E292-E301; first published December 26, 2017. https://doi.org/10.1073/pnas.1716892115
- Open Access
  Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes
  Noriko Itoh, Yuichiro Itoh, Alessia Tassoni, Emily Ren, Max Kaito, Ai Ohno, Yan Ao, Vista Farkhondeh, Hadley Johnsonbaugh, Josh Burda, Michael V. Sofroniew, and Rhonda R. Voskuhl
  
  PNAS January 9, 2018 115 (2) E302-E309; first published December 26, 2017. https://doi.org/10.1073/pnas.1716032115
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  Locus coeruleus input to hippocampal CA3 drives single-trial learning of a novel context
  Akiko Wagatsuma, Teruhiro Okuyama, Chen Sun, Lillian M. Smith, Kuniya Abe, and Susumu Tonegawa
  
  PNAS January 9, 2018 115 (2) E310-E316; first published December 26, 2017. https://doi.org/10.1073/pnas.1714082115
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  Familial Parkinson’s point mutation abolishes multiple system atrophy prion replication
  Amanda L. Woerman, Sabeen A. Kazmi, Smita Patel, Atsushi Aoyagi, Abby Oehler, Kartika Widjaja, Daniel A. Mordes, Steven H. Olson, and Stanley B. Prusiner
  
  PNAS January 9, 2018 115 (2) 409-414; first published December 26, 2017. https://doi.org/10.1073/pnas.1719369115
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  Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons
  Xiangning Li, Bin Yu, Qingtao Sun, Yalun Zhang, Miao Ren, Xiaoyan Zhang, Anan Li, Jing Yuan, Linda Madisen, Qingming Luo, Hongkui Zeng, Hui Gong, and Zilong Qiu
  
  PNAS January 9, 2018 115 (2) 415-420; first published December 19, 2017. https://doi.org/10.1073/pnas.1703601115
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  Genetic variation interacts with experience to determine interindividual differences in learned song
  From the Cover
  
  David G. Mets and Michael S. Brainard
  
  PNAS January 9, 2018 115 (2) 421-426; first published December 26, 2017. https://doi.org/10.1073/pnas.1713031115
Physiology
- Open Access
  Heat activation is intrinsic to the pore domain of TRPV1
  Feng Zhang, Andres Jara-Oseguera, Tsg-Hui Chang, Chanhyung Bae, Sonya M. Hanson, and Kenton J. Swartz
  
  PNAS January 9, 2018 115 (2) E317-E324; first published December 26, 2017. https://doi.org/10.1073/pnas.1717192115
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  ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
  Chong Tang, Rachel Klukovich, Hongying Peng, Zhuqing Wang, Tian Yu, Ying Zhang, Huili Zheng, Arne Klungland, and Wei Yan
  
  PNAS January 9, 2018 115 (2) E325-E333; first published December 26, 2017. https://doi.org/10.1073/pnas.1717794115
- Open Access
  Body weight homeostat that regulates fat mass independently of leptin in rats and mice
  John-Olov Jansson, Vilborg Palsdottir, Daniel A. Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E. Johansson, Roger D. Cone, Daniel J. Drucker, Jianyao Wu, Biljana Aleksic, Anna E. Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H. Windahl, and Claes Ohlsson
  
  PNAS January 9, 2018 115 (2) 427-432; first published December 26, 2017. https://doi.org/10.1073/pnas.1715687114
  
  See companion article:
  Where does the gravitostat fit in?
  - Jan 23, 2018
Plant Biology
- Open Access
  ZmCCT9 enhances maize adaptation to higher latitudes
  Cheng Huang, Huayue Sun, Dingyi Xu, Qiuyue Chen, Yameng Liang, Xufeng Wang, Guanghui Xu, Jinge Tian, Chenglong Wang, Dan Li, Lishuan Wu, Xiaohong Yang, Weiwei Jin, John F. Doebley, and Feng Tian
  
  PNAS January 9, 2018 115 (2) E334-E341; first published December 26, 2017. https://doi.org/10.1073/pnas.1718058115

Correction (Online Only)

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Correction for Singh et al., Increasing potential for intense tropical and subtropical thunderstorms under global warming
PNAS January 9, 2018 115 (2) E342; first published January 2, 2018. https://doi.org/10.1073/pnas.1721679115

Retraction (Online Only)

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Retraction for Jayandharan et al., Activation of the NF-κB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy
PNAS January 9, 2018 115 (2) E343; first published December 26, 2017. https://doi.org/10.1073/pnas.1720655115

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