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Research Article

Body weight homeostat that regulates fat mass independently of leptin in rats and mice

John-Olov Jansson, View ORCID ProfileVilborg Palsdottir, Daniel A. Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E. Johansson, Roger D. Cone, Daniel J. Drucker, Jianyao Wu, Biljana Aleksic, Anna E. Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H. Windahl, and Claes Ohlsson
PNAS January 9, 2018 115 (2) 427-432; first published December 26, 2017; https://doi.org/10.1073/pnas.1715687114
John-Olov Jansson
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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  • For correspondence: joj@neuro.gu.se jgustafs@central.uh.edu Claes.Ohlsson@medic.gu.se
Vilborg Palsdottir
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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  • ORCID record for Vilborg Palsdottir
Daniel A. Hägg
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Erik Schéle
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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Suzanne L. Dickson
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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Fredrik Anesten
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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Tina Bake
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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Mikael Montelius
cDepartment of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Jakob Bellman
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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Maria E. Johansson
aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
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Roger D. Cone
dLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216;
eDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-2216;
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Daniel J. Drucker
fDepartment of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON M5G 1X5, Toronto, Canada;
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Jianyao Wu
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Biljana Aleksic
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Anna E. Törnqvist
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Klara Sjögren
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Jan-Åke Gustafsson
gDepartment of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204
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  • For correspondence: joj@neuro.gu.se jgustafs@central.uh.edu Claes.Ohlsson@medic.gu.se
Sara H. Windahl
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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Claes Ohlsson
bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
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  • For correspondence: joj@neuro.gu.se jgustafs@central.uh.edu Claes.Ohlsson@medic.gu.se
  1. Contributed by Jan-Åke Gustafsson, November 8, 2017 (sent for review September 7, 2017; reviewed by Wolfgang Langhans and Subburaman Mohan)

This article has a Letter. Please see:

  • Weighing the evidence for a body mass-regulating gravitostat - January 23, 2018

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Article Information

vol. 115 no. 2 427-432
DOI: 
https://doi.org/10.1073/pnas.1715687114
PubMed: 
29279372

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue January 9, 2018.
  • Published first December 26, 2017.

Article Versions

  • Previous version (December 26, 2017 - 09:29).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. John-Olov Janssona,1,
  2. Vilborg Palsdottira,
  3. Daniel A. Häggb,
  4. Erik Schélea,
  5. Suzanne L. Dicksona,
  6. Fredrik Anestena,
  7. Tina Bakea,
  8. Mikael Monteliusc,
  9. Jakob Bellmana,
  10. Maria E. Johanssona,
  11. Roger D. Coned,e,
  12. Daniel J. Druckerf,
  13. Jianyao Wub,
  14. Biljana Aleksicb,
  15. Anna E. Törnqvistb,
  16. Klara Sjögrenb,
  17. Jan-Åke Gustafssong,1,
  18. Sara H. Windahlb, and
  19. Claes Ohlssonb,1
  1. aDepartment of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, SE 405 30, Gothenburg, Sweden;
  2. bCentre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
  3. cDepartment of Radiation Physics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, SE 413 45, Gothenburg, Sweden;
  4. dLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216;
  5. eDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109-2216;
  6. fDepartment of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, ON M5G 1X5, Toronto, Canada;
  7. gDepartment of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX 77204
  1. Contributed by Jan-Åke Gustafsson, November 8, 2017 (sent for review September 7, 2017; reviewed by Wolfgang Langhans and Subburaman Mohan)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: joj{at}neuro.gu.se or jgustafs{at}central.uh.edu or Claes.Ohlsson{at}medic.gu.se.
  • Author contributions: J.-O.J., V.P., S.L.D., M.E.J., J.-Å.G., S.H.W., and C.O. designed research; V.P., D.A.H., E.S., F.A., T.B., M.M., J.B., J.W., B.A., A.E.T., K.S., and S.H.W. performed research; R.D.C. and D.J.D. contributed new reagents/analytic tools; J.-O.J., V.P., D.A.H., E.S., T.B., J.B., J.-Å.G., S.H.W., and C.O. analyzed data; and J.-O.J., V.P., J.-Å.G., S.H.W., and C.O. wrote the paper.

  • Reviewers: W.L., ETH Zurich; and S.M., Jerry L. Pettis Memorial VA Medical Center and Loma Linda University.

  • The authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1715687114/-/DCSupplemental.

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Article usage

Article usage: December 2017 to January 2021

AbstractFullPdf
Dec 2017519262761080
Total 2017519262761080
Jan 20181341383012528
Feb 201834183355495
Mar 201815902012373
Apr 20189371086214
May 2018696922184
Jun 20188681125182
Jul 2018561738148
Aug 2018482651359
Sep 2018531654247
Oct 201888508164
Nov 201838514155
Dec 20183339778
Total 201822655202635127
Jan 201963488119
Feb 20194934498
Mar 201944356109
Apr 20195437166
May 2019142367106
Jun 20194030952
Jul 20193630674
Aug 20193731285
Sep 20193732489
Oct 20198336065
Nov 20196927983
Dec 20193428377
Total 201968840991023
Jan 20207636989
Feb 20203637680
Mar 202030322104
Apr 20203932675
May 202024821216
Jun 202018243106
Jul 202010630684
Aug 20203828887
Sep 20203229388
Oct 20204523979
Nov 20204022675
Dec 20208120264
Total 202056540111147
Jan 20212010048
Total 20212010048
Total29120347498425
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Body weight homeostat that regulates fat mass
John-Olov Jansson, Vilborg Palsdottir, Daniel A. Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E. Johansson, Roger D. Cone, Daniel J. Drucker, Jianyao Wu, Biljana Aleksic, Anna E. Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H. Windahl, Claes Ohlsson
Proceedings of the National Academy of Sciences Jan 2018, 115 (2) 427-432; DOI: 10.1073/pnas.1715687114

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Body weight homeostat that regulates fat mass
John-Olov Jansson, Vilborg Palsdottir, Daniel A. Hägg, Erik Schéle, Suzanne L. Dickson, Fredrik Anesten, Tina Bake, Mikael Montelius, Jakob Bellman, Maria E. Johansson, Roger D. Cone, Daniel J. Drucker, Jianyao Wu, Biljana Aleksic, Anna E. Törnqvist, Klara Sjögren, Jan-Åke Gustafsson, Sara H. Windahl, Claes Ohlsson
Proceedings of the National Academy of Sciences Jan 2018, 115 (2) 427-432; DOI: 10.1073/pnas.1715687114
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