Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Optimizing the impact of low-efficacy influenza vaccines

    Pratha Sah, Jan Medlock, Meagan C. Fitzpatrick, Burton H. Singer, and Alison P. Galvani

    PNAS May 15, 2018 115 (20) 5151-5156; first published April 30, 2018. https://doi.org/10.1073/pnas.1802479115

• Biochemistry

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    Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells

    Lingling Fan, Fengbo Zhang, Songhui Xu, Xiaolu Cui, Arif Hussain, Ladan Fazli, Martin Gleave, Xuesen Dong, and Jianfei Qi

    PNAS May 15, 2018 115 (20) E4584-E4593; first published April 30, 2018. https://doi.org/10.1073/pnas.1802415115
  • Open Access

    An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP

    Mackenzie J. Parker, Ailiena O. Maggiolo, William C. Thomas, Albert Kim, Steve P. Meisburger, Nozomi Ando, Amie K. Boal, and JoAnne Stubbe

    PNAS May 15, 2018 115 (20) E4594-E4603; first published April 30, 2018. https://doi.org/10.1073/pnas.1800356115
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    Mechanistic studies of a small-molecule modulator of SMN2 splicing

    Jingxin Wang, Peter G. Schultz, and Kristen A. Johnson

    PNAS May 15, 2018 115 (20) E4604-E4612; first published April 30, 2018. https://doi.org/10.1073/pnas.1800260115
  • Open Access

    Ribosome protection by antibiotic resistance ATP-binding cassette protein

    Weixin Su, Veerendra Kumar, Yichen Ding, Rya Ero, Aida Serra, Benjamin Sian Teck Lee, Andrew See Weng Wong, Jian Shi, Siu Kwan Sze, Liang Yang, and Yong-Gui Gao

    PNAS May 15, 2018 115 (20) 5157-5162; first published April 30, 2018. https://doi.org/10.1073/pnas.1803313115

• Biophysics and Computational Biology

  • Open Access

    Green function of correlated genes in a minimal mechanical model of protein evolution

    Sandipan Dutta, Jean-Pierre Eckmann, Albert Libchaber, and Tsvi Tlusty

    PNAS May 15, 2018 115 (20) E4559-E4568; first published April 30, 2018. https://doi.org/10.1073/pnas.1716215115
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    KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics

    Bojan Milic, Anirban Chakraborty, Kyuho Han, Michael C. Bassik, and Steven M. Block

    PNAS May 15, 2018 115 (20) E4613-E4622; first published April 27, 2018. https://doi.org/10.1073/pnas.1801242115
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    Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins

    Mohsen Pourmousa, Hyun D. Song, Yi He, Jay W. Heinecke, Jere P. Segrest, and Richard W. Pastor

    PNAS May 15, 2018 115 (20) 5163-5168; first published April 30, 2018. https://doi.org/10.1073/pnas.1721181115
  • Open Access

    Butane dihedral angle dynamics in water is dominated by internal friction

    Jan O. Daldrop, Julian Kappler, Florian N. Brünig, and Roland R. Netz

    PNAS May 15, 2018 115 (20) 5169-5174; first published April 30, 2018. https://doi.org/10.1073/pnas.1722327115

• Cell Biology

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    Distinct gating mechanism of SOC channel involving STIM–Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans

    Kyu Min Kim, Tharaka Wijerathne, Jin-Hoe Hur, Uk Jung Kang, Ihn Hyeong Kim, Yeong Cheon Kweon, Ah Reum Lee, Su Ji Jeong, Sang Kwon Lee, Yoon Young Lee, Bo-Woong Sim, Jong-Hee Lee, Chunggi Baig, Sun-Uk Kim, Kyu-Tae Chang, Kyu Pil Lee, and Chan Young Park

    PNAS May 15, 2018 115 (20) E4623-E4632; first published April 30, 2018. https://doi.org/10.1073/pnas.1714986115
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    Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism

    Xing Jian and Gary Felsenfeld

    PNAS May 15, 2018 115 (20) E4633-E4641; first published April 30, 2018. https://doi.org/10.1073/pnas.1803146115

• Developmental Biology

  • Open Access

    A comprehensive omics analysis and functional survey of cuticular proteins in the brown planthopper

    Peng-Lu Pan, Yu-Xuan Ye, Yi-Han Lou, Jia-Bao Lu, Chen Cheng, Yan Shen, Bernard Moussian, and Chuan-Xi Zhang

    PNAS May 15, 2018 115 (20) 5175-5180; first published April 30, 2018. https://doi.org/10.1073/pnas.1716951115

• Ecology

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    Hidden collapse is driven by fire and logging in a socioecological forest ecosystem

    David B. Lindenmayer and Chloe Sato

    PNAS May 15, 2018 115 (20) 5181-5186; first published April 30, 2018. https://doi.org/10.1073/pnas.1721738115
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    Plant acclimation to long-term high nitrogen deposition in an N-rich tropical forest

    Xiankai Lu, Peter M. Vitousek, Qinggong Mao, Frank S. Gilliam, Yiqi Luo, Guoyi Zhou, Xiaoming Zou, Edith Bai, Todd M. Scanlon, Enqing Hou, and Jiangming Mo

    PNAS May 15, 2018 115 (20) 5187-5192; first published May 1, 2018. https://doi.org/10.1073/pnas.1720777115
  • Open Access

    Habitat degradation negatively affects auditory settlement behavior of coral reef fishes

    • From the Cover

    Timothy A. C. Gordon, Harry R. Harding, Kathryn E. Wong, Nathan D. Merchant, Mark G. Meekan, Mark I. McCormick, Andrew N. Radford, and Stephen D. Simpson

    PNAS May 15, 2018 115 (20) 5193-5198; first published April 30, 2018. https://doi.org/10.1073/pnas.1719291115
  • Open Access

    Symbiotic polydnavirus of a parasite manipulates caterpillar and plant immunity

    Ching-Wen Tan, Michelle Peiffer, Kelli Hoover, Cristina Rosa, Flor E. Acevedo, and Gary W. Felton

    PNAS May 15, 2018 115 (20) 5199-5204; first published April 30, 2018. https://doi.org/10.1073/pnas.1717934115

    See companion article:

    • Symbiotic polydnavirus and venom reveal parasitoid to its hyperparasitoids

      - May 15, 2018
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    Symbiotic polydnavirus and venom reveal parasitoid to its hyperparasitoids

    Feng Zhu, Antonino Cusumano, Janneke Bloem, Berhane T. Weldegergis, Alexandre Villela, Nina E. Fatouros, Joop J. A. van Loon, Marcel Dicke, Jeffrey A. Harvey, Heiko Vogel, and Erik H. Poelman

    PNAS May 15, 2018 115 (20) 5205-5210; first published April 30, 2018. https://doi.org/10.1073/pnas.1717904115

    See companion article:

    • Symbiotic polydnavirus of a parasite manipulates caterpillar and plant immunity

      - May 15, 2018
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    Global shifts in the phenological synchrony of species interactions over recent decades

    • From the Cover

    Heather M. Kharouba, Johan Ehrlén, Andrew Gelman, Kjell Bolmgren, Jenica M. Allen, Steve E. Travers, and Elizabeth M. Wolkovich

    PNAS May 15, 2018 115 (20) 5211-5216; first published April 16, 2018. https://doi.org/10.1073/pnas.1714511115

    See companion article:

    • Adaptive and nonadaptive changes in phenological synchrony

      - May 15, 2018

• Evolution

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    Escherichia coli cultures maintain stable subpopulation structure during long-term evolution

    Megan G. Behringer, Brian I. Choi, Samuel F. Miller, Thomas G. Doak, Jonathan A. Karty, Wanfeng Guo, and Michael Lynch

    PNAS May 15, 2018 115 (20) E4642-E4650; first published April 30, 2018. https://doi.org/10.1073/pnas.1708371115
  • Open Access

    Quantifying ecological impacts of mass extinctions with network analysis of fossil communities

    A. D. Muscente, Anirudh Prabhu, Hao Zhong, Ahmed Eleish, Michael B. Meyer, Peter Fox, Robert M. Hazen, and Andrew H. Knoll

    PNAS May 15, 2018 115 (20) 5217-5222; first published April 23, 2018. https://doi.org/10.1073/pnas.1719976115
  • Open Access

    Genomic adaptation to drought in wild barley is driven by edaphic natural selection at the Tabigha Evolution Slope

    Xiaolei Wang, Zhong-Hua Chen, Chongyi Yang, Xuelei Zhang, Gulei Jin, Guang Chen, Yuanyuan Wang, Paul Holford, Eviatar Nevo, Guoping Zhang, and Fei Dai

    PNAS May 15, 2018 115 (20) 5223-5228; first published April 30, 2018. https://doi.org/10.1073/pnas.1721749115
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    Symbiont switching and alternative resource acquisition strategies drive mutualism breakdown

    Gijsbert D. A. Werner, Johannes H. C. Cornelissen, William K. Cornwell, Nadejda A. Soudzilovskaia, Jens Kattge, Stuart A. West, and E. Toby Kiers

    PNAS May 15, 2018 115 (20) 5229-5234; first published April 30, 2018. https://doi.org/10.1073/pnas.1721629115

• Genetics

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    CRISPR/Cas9-mediated genome editing in a reef-building coral

    • From the Cover

    Phillip A. Cleves, Marie E. Strader, Line K. Bay, John R. Pringle, and Mikhail V. Matz

    PNAS May 15, 2018 115 (20) 5235-5240; first published April 25, 2018. https://doi.org/10.1073/pnas.1722151115
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    Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1

    Aaron Seo, Orna Steinberg-Shemer, Sule Unal, Silvia Casadei, Tom Walsh, Fatma Gumruk, Stavit Shalev, Akiko Shimamura, Nurten Ayse Akarsu, Hannah Tamary, and Mary-Claire King

    PNAS May 15, 2018 115 (20) 5241-5246; first published April 30, 2018. https://doi.org/10.1073/pnas.1801796115
  • Open Access

    Systematic analysis of copy number variation associated with congenital diaphragmatic hernia

    Qihui Zhu, Frances A. High, Chengsheng Zhang, Eliza Cerveira, Meaghan K. Russell, Mauro Longoni, Maliackal P. Joy, Mallory Ryan, Adam Mil-homens, Lauren Bellfy, Caroline M. Coletti, Pooja Bhayani, Regis Hila, Jay M. Wilson, Patricia K. Donahoe, and Charles Lee

    PNAS May 15, 2018 115 (20) 5247-5252; first published April 30, 2018. https://doi.org/10.1073/pnas.1714885115

• Immunology and Inflammation

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    Metabolic control of T cell immune response through glycans in inflammatory bowel disease

    Ana M. Dias, Alexandra Correia, Márcia S. Pereira, Catarina R. Almeida, Inês Alves, Vanda Pinto, Telmo A. Catarino, Nuno Mendes, Magdalena Leander, M. Teresa Oliva-Teles, Luís Maia, Cristina Delerue-Matos, Naoyuki Taniguchi, Margarida Lima, Isabel Pedroto, Ricardo Marcos-Pinto, Paula Lago, Celso A. Reis, Manuel Vilanova, and Salomé S. Pinho

    PNAS May 15, 2018 115 (20) E4651-E4660; first published May 2, 2018. https://doi.org/10.1073/pnas.1720409115
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    The C-terminal extension landscape of naturally presented HLA-I ligands

    Philippe Guillaume, Sarah Picaud, Petra Baumgaertner, Nicole Montandon, Julien Schmidt, Daniel E. Speiser, George Coukos, Michal Bassani-Sternberg, Panagis Filippakopoulos, and David Gfeller

    PNAS May 15, 2018 115 (20) 5083-5088; first published April 30, 2018. https://doi.org/10.1073/pnas.1717277115
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    Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice

    Hideyuki Yanai, Shiho Chiba, Sho Hangai, Kohei Kometani, Asuka Inoue, Yoshitaka Kimura, Takaya Abe, Hiroshi Kiyonari, Junko Nishio, Naoko Taguchi-Atarashi, Yu Mizushima, Hideo Negishi, Rudolf Grosschedl, and Tadatsugu Taniguchi

    PNAS May 15, 2018 115 (20) 5253-5258; first published April 30, 2018. https://doi.org/10.1073/pnas.1803936115
  • Open Access

    Less immune activation following social stress in rural vs. urban participants raised with regular or no animal contact, respectively

    Till S. Böbel, Sascha B. Hackl, Dominik Langgartner, Marc N. Jarczok, Nicolas Rohleder, Graham A. Rook, Christopher A. Lowry, Harald Gündel, Christiane Waller, and Stefan O. Reber

    PNAS May 15, 2018 115 (20) 5259-5264; first published April 30, 2018. https://doi.org/10.1073/pnas.1719866115
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    Revealing the specificity of regulatory T cells in murine autoimmune diabetes

    Allyson Spence, Whitney Purtha, Janice Tam, Shen Dong, Youmin Kim, Chia-Hsin Ju, Teague Sterling, Maki Nakayama, William H. Robinson, Jeffrey A. Bluestone, Mark S. Anderson, and Qizhi Tang

    PNAS May 15, 2018 115 (20) 5265-5270; first published April 30, 2018. https://doi.org/10.1073/pnas.1715590115

• Medical Sciences

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    Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy

    Xudong Liao, Yuyan Shen, Rongli Zhang, Keiki Sugi, Neelakantan T. Vasudevan, M. Amer Alaiti, David R. Sweet, Lin Zhou, Yulan Qing, Stanton L. Gerson, Chen Fu, Anthony Wynshaw-Boris, Rui Hu, Martin A. Schwartz, Hisashi Fujioka, Brian Richardson, Mark J. Cameron, Hiroki Hayashi, Jonathan S. Stamler, and Mukesh K. Jain

    PNAS May 15, 2018 115 (20) E4661-E4669; first published April 30, 2018. https://doi.org/10.1073/pnas.1720065115

• Microbiology

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    Imaging mycobacterial growth and division with a fluorogenic probe

    Heather L. Hodges, Robert A. Brown, John A. Crooks, Douglas B. Weibel, and Laura L. Kiessling

    PNAS May 15, 2018 115 (20) 5271-5276; first published April 27, 2018. https://doi.org/10.1073/pnas.1720996115

• Neuroscience

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    Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells

    Tassilo Jungenitz, Marcel Beining, Tijana Radic, Thomas Deller, Hermann Cuntz, Peter Jedlicka, and Stephan W. Schwarzacher

    PNAS May 15, 2018 115 (20) E4670-E4679; first published April 30, 2018. https://doi.org/10.1073/pnas.1801889115
  • Open Access

    Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress

    • Inaugural Article

    Da Meng, Hui-quan Li, Karl Deisseroth, Stefan Leutgeb, and Nicholas C. Spitzer

    PNAS May 15, 2018 115 (20) 5064-5071; first published April 23, 2018. https://doi.org/10.1073/pnas.1801598115

    See companion article:

    • QnAs with Nicholas C. Spitzer

      - May 15, 2018
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    Structured networks support sparse traveling waves in rodent somatosensory cortex

    Samat Moldakarimov, Maxim Bazhenov, Daniel E. Feldman, and Terrence J. Sejnowski

    PNAS May 15, 2018 115 (20) 5277-5282; first published April 30, 2018. https://doi.org/10.1073/pnas.1710202115

• Pharmacology

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    Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

    Weicang Wang, Jun Yang, Jianan Zhang, Yuxin Wang, Sung Hee Hwang, Weipeng Qi, Debin Wan, Daeyoung Kim, Jia Sun, Katherine Z. Sanidad, Haixia Yang, Yeonhwa Park, Jun-Yan Liu, Xinfeng Zhao, Xiaohui Zheng, Zhenhua Liu, Bruce D. Hammock, and Guodong Zhang

    PNAS May 15, 2018 115 (20) 5283-5288; first published May 1, 2018. https://doi.org/10.1073/pnas.1721711115

    See companion article:

    • Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis

      - Jun 05, 2018

• Physiology

  • Open Access

    Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

    • From the Cover

    Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Bonne M. Thompson, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, and Christopher K. Glass

    PNAS May 15, 2018 115 (20) E4680-E4689; first published April 9, 2018. https://doi.org/10.1073/pnas.1714518115

    See companion article:

    • Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis

      - May 15, 2018

• Plant Biology

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    Loss of a highly conserved sterile alpha motif domain gene (WEEP) results in pendulous branch growth in peach trees

    Courtney A. Hollender, Thierry Pascal, Amy Tabb, Toto Hadiarto, Chinnathambi Srinivasan, Wanpeng Wang, Zhongchi Liu, Ralph Scorza, and Chris Dardick

    PNAS May 15, 2018 115 (20) E4690-E4699; first published April 30, 2018. https://doi.org/10.1073/pnas.1704515115
  • Open Access

    Comparative genomics of the nonlegume Parasponia reveals insights into evolution of nitrogen-fixing rhizobium symbioses

    Robin van Velzen, Rens Holmer, Fengjiao Bu, Luuk Rutten, Arjan van Zeijl, Wei Liu, Luca Santuari, Qingqin Cao, Trupti Sharma, Defeng Shen, Yuda Roswanjaya, Titis A. K. Wardhani, Maryam Seifi Kalhor, Joelle Jansen, Johan van den Hoogen, Berivan Güngör, Marijke Hartog, Jan Hontelez, Jan Verver, Wei-Cai Yang, Elio Schijlen, Rimi Repin, Menno Schilthuizen, M. Eric Schranz, Renze Heidstra, Kana Miyata, Elena Fedorova, Wouter Kohlen, Ton Bisseling, Sandra Smit, and Rene Geurts

    PNAS May 15, 2018 115 (20) E4700-E4709; first published May 1, 2018. https://doi.org/10.1073/pnas.1721395115
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    MYB30 links ROS signaling, root cell elongation, and plant immune responses

    Kaho Mabuchi, Hiromasa Maki, Tomotaka Itaya, Takamasa Suzuki, Mika Nomoto, Satomi Sakaoka, Atsushi Morikami, Tetsuya Higashiyama, Yasuomi Tada, Wolfgang Busch, and Hironaka Tsukagoshi

    PNAS May 15, 2018 115 (20) E4710-E4719; first published April 30, 2018. https://doi.org/10.1073/pnas.1804233115
  • Open Access

    FACT complex is required for DNA demethylation at heterochromatin during reproduction in Arabidopsis

    Jennifer M. Frost, M. Yvonne Kim, Guen Tae Park, Ping-Hung Hsieh, Miyuki Nakamura, Samuel J. H. Lin, Hyunjin Yoo, Jaemyung Choi, Yoko Ikeda, Tetsu Kinoshita, Yeonhee Choi, Daniel Zilberman, and Robert L. Fischer

    PNAS May 15, 2018 115 (20) E4720-E4729; first published April 30, 2018. https://doi.org/10.1073/pnas.1713333115
  • Open Access

    Gravisensors in plant cells behave like an active granular liquid

    Antoine Bérut, Hugo Chauvet, Valérie Legué, Bruno Moulia, Olivier Pouliquen, and Yoël Forterre

    PNAS May 15, 2018 115 (20) 5123-5128; first published April 30, 2018. https://doi.org/10.1073/pnas.1801895115
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    Symbiotic root infections in Medicago truncatula require remorin-mediated receptor stabilization in membrane nanodomains

    Pengbo Liang, Thomas F. Stratil, Claudia Popp, Macarena Marín, Jessica Folgmann, Kirankumar S. Mysore, Jiangqi Wen, and Thomas Ott

    PNAS May 15, 2018 115 (20) 5289-5294; first published April 30, 2018. https://doi.org/10.1073/pnas.1721868115

• Sustainability Science

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    Comparative terrestrial feed and land use of an aquaculture-dominant world

    Halley E. Froehlich, Claire A. Runge, Rebecca R. Gentry, Steven D. Gaines, and Benjamin S. Halpern

    PNAS May 15, 2018 115 (20) 5295-5300; first published April 30, 2018. https://doi.org/10.1073/pnas.1801692115