Proceedings of the National Academy of Sciences: 115 (20)

New Research In

May 15, 2018; vol. 115 no. 20

This Week in PNAS

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In This Issue
PNAS May 15, 2018 115 (20) 5041; https://doi.org/10.1073/iti2018115

Letters (Online Only)

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Asking endosymbionts to do an enzyme’s job
Sriram G. Garg and William F. Martin

PNAS May 15, 2018 115 (20) E4543-E4544; first published May 3, 2018. https://doi.org/10.1073/pnas.1804397115
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Reply to Garg and Martin: The mechanism works
István Zachar, András Szilágyi, Szabolcs Számadó, and Eörs Szathmáry

PNAS May 15, 2018 115 (20) E4545-E4546; first published May 3, 2018. https://doi.org/10.1073/pnas.1805021115
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Farming hypothesis of mitochondrial origins
- Jan 30, 2018
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Diet influences host–microbiota associations in Drosophila
Benjamin Obadia, Erin S. Keebaugh, Ryuichi Yamada, William B. Ludington, and William W. Ja

PNAS May 15, 2018 115 (20) E4547-E4548; first published May 7, 2018. https://doi.org/10.1073/pnas.1804948115
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Reply to Obadia et al.: Effect of methyl paraben on host–microbiota interactions in Drosophila melanogaster
Philip T. Leftwich, Naomi V. E. Clarke, Matthew I. Hutchings, and Tracey Chapman

PNAS May 15, 2018 115 (20) E4549-E4550; first published May 7, 2018. https://doi.org/10.1073/pnas.1805499115
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Commensal bacteria play a role in mating preference of Drosophila melanogaster
- Nov 01, 2010

Opinion

Leading scientists discuss current issues.

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Opinion: Reproducibility failures are essential to scientific inquiry
Front Matter
A. David Redish, Erich Kummerfeld, Rebecca Lea Morris, and Alan C. Love

PNAS May 15, 2018 115 (20) 5042-5046; https://doi.org/10.1073/pnas.1806370115

QnAs

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QnAs with Nicholas C. Spitzer
Paul Gabrielsen

PNAS May 15, 2018 115 (20) 5047-5048; first published April 23, 2018. https://doi.org/10.1073/pnas.1805781115
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Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress
- Apr 23, 2018

Retrospective

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Jack Halpern (1925–2018): Pioneer of homogeneous catalysis
John E. Bercaw

PNAS May 15, 2018 115 (20) 5049-5050; first published April 25, 2018. https://doi.org/10.1073/pnas.1806116115

Commentaries

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Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis
Jason A. Magida and Ronald M. Evans

PNAS May 15, 2018 115 (20) 5051-5053; first published April 30, 2018. https://doi.org/10.1073/pnas.1805128115
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Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
- Apr 09, 2018
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Incorporating light atoms into synthetic analogues of FeMoco
Daniel E. DeRosha and Patrick L. Holland

PNAS May 15, 2018 115 (20) 5054-5056; first published April 30, 2018. https://doi.org/10.1073/pnas.1805700115
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Ligand metathesis as rational strategy for the synthesis of cubane-type heteroleptic iron–sulfur clusters relevant to the FeMo cofactor
- Apr 13, 2018
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Adaptive and nonadaptive changes in phenological synchrony
Andreas Lindén

PNAS May 15, 2018 115 (20) 5057-5059; first published April 30, 2018. https://doi.org/10.1073/pnas.1805698115
See companion article:
Global shifts in the phenological synchrony of species interactions over recent decades
- Apr 16, 2018

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS May 15, 2018 115 (20) 5060-5063; https://doi.org/10.1073/pnas.ss11520

Physical Sciences

Applied Physical Sciences
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  Quantum indistinguishability in chemical reactions
  Matthew P. A. Fisher and Leo Radzihovsky
  
  PNAS May 15, 2018 115 (20) E4551-E4558; first published April 30, 2018. https://doi.org/10.1073/pnas.1718402115
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  Mass-correlated rotational Raman spectra with high resolution, broad bandwidth, and absolute frequency accuracy
  Christian Schröter, Jong Chan Lee, and Thomas Schultz
  
  PNAS May 15, 2018 115 (20) 5072-5076; first published April 27, 2018. https://doi.org/10.1073/pnas.1721756115
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  Site-selective measurement of coupled spin pairs in an organic semiconductor
  S. L. Bayliss, L. R. Weiss, A. Mitioglu, K. Galkowski, Z. Yang, K. Yunusova, A. Surrente, K. J. Thorley, J. Behrends, R. Bittl, J. E. Anthony, A. Rao, R. H. Friend, P. Plochocka, P. C. M. Christianen, N. C. Greenham, and A. D. Chepelianskii
  
  PNAS May 15, 2018 115 (20) 5077-5082; first published May 2, 2018. https://doi.org/10.1073/pnas.1718868115
Biophysics and Computational Biology
- Open Access
  Green function of correlated genes in a minimal mechanical model of protein evolution
  Sandipan Dutta, Jean-Pierre Eckmann, Albert Libchaber, and Tsvi Tlusty
  
  PNAS May 15, 2018 115 (20) E4559-E4568; first published April 30, 2018. https://doi.org/10.1073/pnas.1716215115
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  The C-terminal extension landscape of naturally presented HLA-I ligands
  Philippe Guillaume, Sarah Picaud, Petra Baumgaertner, Nicole Montandon, Julien Schmidt, Daniel E. Speiser, George Coukos, Michal Bassani-Sternberg, Panagis Filippakopoulos, and David Gfeller
  
  PNAS May 15, 2018 115 (20) 5083-5088; first published April 30, 2018. https://doi.org/10.1073/pnas.1717277115
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  Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins
  Mohsen Pourmousa, Hyun D. Song, Yi He, Jay W. Heinecke, Jere P. Segrest, and Richard W. Pastor
  
  PNAS May 15, 2018 115 (20) 5163-5168; first published April 30, 2018. https://doi.org/10.1073/pnas.1721181115
Chemistry
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  Local initiation conditions for water autoionization
  Mahmoud Moqadam, Anders Lervik, Enrico Riccardi, Vishwesh Venkatraman, Bjørn Kåre Alsberg, and Titus S. van Erp
  
  PNAS May 15, 2018 115 (20) E4569-E4576; first published April 30, 2018. https://doi.org/10.1073/pnas.1714070115
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  Tunneling explains efficient electron transport via protein junctions
  Jerry A. Fereiro, Xi Yu, Israel Pecht, Mordechai Sheves, Juan Carlos Cuevas, and David Cahen
  
  PNAS May 15, 2018 115 (20) E4577-E4583; first published April 30, 2018. https://doi.org/10.1073/pnas.1719867115
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  Ligand metathesis as rational strategy for the synthesis of cubane-type heteroleptic iron–sulfur clusters relevant to the FeMo cofactor
  From the Cover
  
  Gan Xu, Zheng Wang, Rong Ling, Jie Zhou, Xu-Dong Chen, and Richard H. Holm
  
  PNAS May 15, 2018 115 (20) 5089-5092; first published April 13, 2018. https://doi.org/10.1073/pnas.1801025115
  
  See companion article:
  Incorporating light atoms into synthetic analogues of FeMoco
  - Apr 30, 2018
- Open Access
  Catalytic amino acid production from biomass-derived intermediates
  Weiping Deng, Yunzhu Wang, Sui Zhang, Krishna M. Gupta, Max J. Hülsey, Hiroyuki Asakura, Lingmei Liu, Yu Han, Eric M. Karp, Gregg T. Beckham, Paul J. Dyson, Jianwen Jiang, Tsunehiro Tanaka, Ye Wang, and Ning Yan
  
  PNAS May 15, 2018 115 (20) 5093-5098; first published April 30, 2018. https://doi.org/10.1073/pnas.1800272115
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  Imaging mycobacterial growth and division with a fluorogenic probe
  Heather L. Hodges, Robert A. Brown, John A. Crooks, Douglas B. Weibel, and Laura L. Kiessling
  
  PNAS May 15, 2018 115 (20) 5271-5276; first published April 27, 2018. https://doi.org/10.1073/pnas.1720996115
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Unexpected slowdown of US pollutant emission reduction in the past decade
  Zhe Jiang, Brian C. McDonald, Helen Worden, John R. Worden, Kazuyuki Miyazaki, Zhen Qu, Daven K. Henze, Dylan B. A. Jones, Avelino F. Arellano, Emily V. Fischer, Liye Zhu, and K. Folkert Boersma
  
  PNAS May 15, 2018 115 (20) 5099-5104; first published April 30, 2018. https://doi.org/10.1073/pnas.1801191115
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  Quantifying flow and stress in ice mélange, the world’s largest granular material
  Justin C. Burton, Jason M. Amundson, Ryan Cassotto, Chin-Chang Kuo, and Michael Dennin
  
  PNAS May 15, 2018 115 (20) 5105-5110; first published April 30, 2018. https://doi.org/10.1073/pnas.1715136115
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  Earth’s magnetic field is probably not reversing
  Maxwell Brown, Monika Korte, Richard Holme, Ingo Wardinski, and Sydney Gunnarson
  
  PNAS May 15, 2018 115 (20) 5111-5116; first published April 30, 2018. https://doi.org/10.1073/pnas.1722110115
- Open Access
  Quantifying ecological impacts of mass extinctions with network analysis of fossil communities
  A. D. Muscente, Anirudh Prabhu, Hao Zhong, Ahmed Eleish, Michael B. Meyer, Peter Fox, Robert M. Hazen, and Andrew H. Knoll
  
  PNAS May 15, 2018 115 (20) 5217-5222; first published April 23, 2018. https://doi.org/10.1073/pnas.1719976115
Engineering
- Open Access
  Roughness-dependent tribology effects on discontinuous shear thickening
  Chiao-Peng Hsu, Shivaprakash N. Ramakrishna, Michele Zanini, Nicholas D. Spencer, and Lucio Isa
  
  PNAS May 15, 2018 115 (20) 5117-5122; first published May 1, 2018. https://doi.org/10.1073/pnas.1801066115
Physics
- Open Access
  Gravisensors in plant cells behave like an active granular liquid
  Antoine Bérut, Hugo Chauvet, Valérie Legué, Bruno Moulia, Olivier Pouliquen, and Yoël Forterre
  
  PNAS May 15, 2018 115 (20) 5123-5128; first published April 30, 2018. https://doi.org/10.1073/pnas.1801895115
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  Support for the value 5/2 for the spin glass lower critical dimension at zero magnetic field
  Andrea Maiorano and Giorgio Parisi
  
  PNAS May 15, 2018 115 (20) 5129-5134; first published May 1, 2018. https://doi.org/10.1073/pnas.1720832115
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  High-order fractal states in graphene superlattices
  R. Krishna Kumar, A. Mishchenko, X. Chen, S. Pezzini, G. H. Auton, L. A. Ponomarenko, U. Zeitler, L. Eaves, V. I. Fal’ko, and A. K. Geim
  
  PNAS May 15, 2018 115 (20) 5135-5139; first published April 30, 2018. https://doi.org/10.1073/pnas.1804572115
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  Doped Kondo chain, a heavy Luttinger liquid
  Ilia Khait, Patrick Azaria, Claudius Hubig, Ulrich Schollwöck, and Assa Auerbach
  
  PNAS May 15, 2018 115 (20) 5140-5144; first published April 30, 2018. https://doi.org/10.1073/pnas.1719374115

Biological Sciences

Applied Biological Sciences
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  Optimizing the impact of low-efficacy influenza vaccines
  Pratha Sah, Jan Medlock, Meagan C. Fitzpatrick, Burton H. Singer, and Alison P. Galvani
  
  PNAS May 15, 2018 115 (20) 5151-5156; first published April 30, 2018. https://doi.org/10.1073/pnas.1802479115
Biochemistry
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  Histone demethylase JMJD1A promotes alternative splicing of AR variant 7 (AR-V7) in prostate cancer cells
  Lingling Fan, Fengbo Zhang, Songhui Xu, Xiaolu Cui, Arif Hussain, Ladan Fazli, Martin Gleave, Xuesen Dong, and Jianfei Qi
  
  PNAS May 15, 2018 115 (20) E4584-E4593; first published April 30, 2018. https://doi.org/10.1073/pnas.1802415115
- Open Access
  An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP
  Mackenzie J. Parker, Ailiena O. Maggiolo, William C. Thomas, Albert Kim, Steve P. Meisburger, Nozomi Ando, Amie K. Boal, and JoAnne Stubbe
  
  PNAS May 15, 2018 115 (20) E4594-E4603; first published April 30, 2018. https://doi.org/10.1073/pnas.1800356115
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  Mechanistic studies of a small-molecule modulator of SMN2 splicing
  Jingxin Wang, Peter G. Schultz, and Kristen A. Johnson
  
  PNAS May 15, 2018 115 (20) E4604-E4612; first published April 30, 2018. https://doi.org/10.1073/pnas.1800260115
- Open Access
  Ribosome protection by antibiotic resistance ATP-binding cassette protein
  Weixin Su, Veerendra Kumar, Yichen Ding, Rya Ero, Aida Serra, Benjamin Sian Teck Lee, Andrew See Weng Wong, Jian Shi, Siu Kwan Sze, Liang Yang, and Yong-Gui Gao
  
  PNAS May 15, 2018 115 (20) 5157-5162; first published April 30, 2018. https://doi.org/10.1073/pnas.1803313115
Biophysics and Computational Biology
- Open Access
  Green function of correlated genes in a minimal mechanical model of protein evolution
  Sandipan Dutta, Jean-Pierre Eckmann, Albert Libchaber, and Tsvi Tlusty
  
  PNAS May 15, 2018 115 (20) E4559-E4568; first published April 30, 2018. https://doi.org/10.1073/pnas.1716215115
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  KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics
  Bojan Milic, Anirban Chakraborty, Kyuho Han, Michael C. Bassik, and Steven M. Block
  
  PNAS May 15, 2018 115 (20) E4613-E4622; first published April 27, 2018. https://doi.org/10.1073/pnas.1801242115
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  Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins
  Mohsen Pourmousa, Hyun D. Song, Yi He, Jay W. Heinecke, Jere P. Segrest, and Richard W. Pastor
  
  PNAS May 15, 2018 115 (20) 5163-5168; first published April 30, 2018. https://doi.org/10.1073/pnas.1721181115
- Open Access
  Butane dihedral angle dynamics in water is dominated by internal friction
  Jan O. Daldrop, Julian Kappler, Florian N. Brünig, and Roland R. Netz
  
  PNAS May 15, 2018 115 (20) 5169-5174; first published April 30, 2018. https://doi.org/10.1073/pnas.1722327115
Cell Biology
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  Distinct gating mechanism of SOC channel involving STIM–Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans
  Kyu Min Kim, Tharaka Wijerathne, Jin-Hoe Hur, Uk Jung Kang, Ihn Hyeong Kim, Yeong Cheon Kweon, Ah Reum Lee, Su Ji Jeong, Sang Kwon Lee, Yoon Young Lee, Bo-Woong Sim, Jong-Hee Lee, Chunggi Baig, Sun-Uk Kim, Kyu-Tae Chang, Kyu Pil Lee, and Chan Young Park
  
  PNAS May 15, 2018 115 (20) E4623-E4632; first published April 30, 2018. https://doi.org/10.1073/pnas.1714986115
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  Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism
  Xing Jian and Gary Felsenfeld
  
  PNAS May 15, 2018 115 (20) E4633-E4641; first published April 30, 2018. https://doi.org/10.1073/pnas.1803146115
Developmental Biology
- Open Access
  A comprehensive omics analysis and functional survey of cuticular proteins in the brown planthopper
  Peng-Lu Pan, Yu-Xuan Ye, Yi-Han Lou, Jia-Bao Lu, Chen Cheng, Yan Shen, Bernard Moussian, and Chuan-Xi Zhang
  
  PNAS May 15, 2018 115 (20) 5175-5180; first published April 30, 2018. https://doi.org/10.1073/pnas.1716951115
Ecology
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  Hidden collapse is driven by fire and logging in a socioecological forest ecosystem
  David B. Lindenmayer and Chloe Sato
  
  PNAS May 15, 2018 115 (20) 5181-5186; first published April 30, 2018. https://doi.org/10.1073/pnas.1721738115
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  Plant acclimation to long-term high nitrogen deposition in an N-rich tropical forest
  Xiankai Lu, Peter M. Vitousek, Qinggong Mao, Frank S. Gilliam, Yiqi Luo, Guoyi Zhou, Xiaoming Zou, Edith Bai, Todd M. Scanlon, Enqing Hou, and Jiangming Mo
  
  PNAS May 15, 2018 115 (20) 5187-5192; first published May 1, 2018. https://doi.org/10.1073/pnas.1720777115
- Open Access
  Habitat degradation negatively affects auditory settlement behavior of coral reef fishes
  From the Cover
  
  Timothy A. C. Gordon, Harry R. Harding, Kathryn E. Wong, Nathan D. Merchant, Mark G. Meekan, Mark I. McCormick, Andrew N. Radford, and Stephen D. Simpson
  
  PNAS May 15, 2018 115 (20) 5193-5198; first published April 30, 2018. https://doi.org/10.1073/pnas.1719291115
- Open Access
  Symbiotic polydnavirus of a parasite manipulates caterpillar and plant immunity
  Ching-Wen Tan, Michelle Peiffer, Kelli Hoover, Cristina Rosa, Flor E. Acevedo, and Gary W. Felton
  
  PNAS May 15, 2018 115 (20) 5199-5204; first published April 30, 2018. https://doi.org/10.1073/pnas.1717934115
  
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  Symbiotic polydnavirus and venom reveal parasitoid to its hyperparasitoids
  - Apr 30, 2018
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  Symbiotic polydnavirus and venom reveal parasitoid to its hyperparasitoids
  Feng Zhu, Antonino Cusumano, Janneke Bloem, Berhane T. Weldegergis, Alexandre Villela, Nina E. Fatouros, Joop J. A. van Loon, Marcel Dicke, Jeffrey A. Harvey, Heiko Vogel, and Erik H. Poelman
  
  PNAS May 15, 2018 115 (20) 5205-5210; first published April 30, 2018. https://doi.org/10.1073/pnas.1717904115
  
  See companion article:
  Symbiotic polydnavirus of a parasite manipulates caterpillar and plant immunity
  - Apr 30, 2018
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  Global shifts in the phenological synchrony of species interactions over recent decades
  From the Cover
  
  Heather M. Kharouba, Johan Ehrlén, Andrew Gelman, Kjell Bolmgren, Jenica M. Allen, Steve E. Travers, and Elizabeth M. Wolkovich
  
  PNAS May 15, 2018 115 (20) 5211-5216; first published April 16, 2018. https://doi.org/10.1073/pnas.1714511115
  
  See companion article:
  Adaptive and nonadaptive changes in phenological synchrony
  - Apr 30, 2018
Evolution
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  Escherichia coli cultures maintain stable subpopulation structure during long-term evolution
  Megan G. Behringer, Brian I. Choi, Samuel F. Miller, Thomas G. Doak, Jonathan A. Karty, Wanfeng Guo, and Michael Lynch
  
  PNAS May 15, 2018 115 (20) E4642-E4650; first published April 30, 2018. https://doi.org/10.1073/pnas.1708371115
- Open Access
  Quantifying ecological impacts of mass extinctions with network analysis of fossil communities
  A. D. Muscente, Anirudh Prabhu, Hao Zhong, Ahmed Eleish, Michael B. Meyer, Peter Fox, Robert M. Hazen, and Andrew H. Knoll
  
  PNAS May 15, 2018 115 (20) 5217-5222; first published April 23, 2018. https://doi.org/10.1073/pnas.1719976115
- Open Access
  Genomic adaptation to drought in wild barley is driven by edaphic natural selection at the Tabigha Evolution Slope
  Xiaolei Wang, Zhong-Hua Chen, Chongyi Yang, Xuelei Zhang, Gulei Jin, Guang Chen, Yuanyuan Wang, Paul Holford, Eviatar Nevo, Guoping Zhang, and Fei Dai
  
  PNAS May 15, 2018 115 (20) 5223-5228; first published April 30, 2018. https://doi.org/10.1073/pnas.1721749115
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  Symbiont switching and alternative resource acquisition strategies drive mutualism breakdown
  Gijsbert D. A. Werner, Johannes H. C. Cornelissen, William K. Cornwell, Nadejda A. Soudzilovskaia, Jens Kattge, Stuart A. West, and E. Toby Kiers
  
  PNAS May 15, 2018 115 (20) 5229-5234; first published April 30, 2018. https://doi.org/10.1073/pnas.1721629115
Genetics
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  CRISPR/Cas9-mediated genome editing in a reef-building coral
  From the Cover
  
  Phillip A. Cleves, Marie E. Strader, Line K. Bay, John R. Pringle, and Mikhail V. Matz
  
  PNAS May 15, 2018 115 (20) 5235-5240; first published April 25, 2018. https://doi.org/10.1073/pnas.1722151115
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  Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1
  Aaron Seo, Orna Steinberg-Shemer, Sule Unal, Silvia Casadei, Tom Walsh, Fatma Gumruk, Stavit Shalev, Akiko Shimamura, Nurten Ayse Akarsu, Hannah Tamary, and Mary-Claire King
  
  PNAS May 15, 2018 115 (20) 5241-5246; first published April 30, 2018. https://doi.org/10.1073/pnas.1801796115
- Open Access
  Systematic analysis of copy number variation associated with congenital diaphragmatic hernia
  Qihui Zhu, Frances A. High, Chengsheng Zhang, Eliza Cerveira, Meaghan K. Russell, Mauro Longoni, Maliackal P. Joy, Mallory Ryan, Adam Mil-homens, Lauren Bellfy, Caroline M. Coletti, Pooja Bhayani, Regis Hila, Jay M. Wilson, Patricia K. Donahoe, and Charles Lee
  
  PNAS May 15, 2018 115 (20) 5247-5252; first published April 30, 2018. https://doi.org/10.1073/pnas.1714885115
Immunology and Inflammation
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  Metabolic control of T cell immune response through glycans in inflammatory bowel disease
  Ana M. Dias, Alexandra Correia, Márcia S. Pereira, Catarina R. Almeida, Inês Alves, Vanda Pinto, Telmo A. Catarino, Nuno Mendes, Magdalena Leander, M. Teresa Oliva-Teles, Luís Maia, Cristina Delerue-Matos, Naoyuki Taniguchi, Margarida Lima, Isabel Pedroto, Ricardo Marcos-Pinto, Paula Lago, Celso A. Reis, Manuel Vilanova, and Salomé S. Pinho
  
  PNAS May 15, 2018 115 (20) E4651-E4660; first published May 2, 2018. https://doi.org/10.1073/pnas.1720409115
- You have access
  The C-terminal extension landscape of naturally presented HLA-I ligands
  Philippe Guillaume, Sarah Picaud, Petra Baumgaertner, Nicole Montandon, Julien Schmidt, Daniel E. Speiser, George Coukos, Michal Bassani-Sternberg, Panagis Filippakopoulos, and David Gfeller
  
  PNAS May 15, 2018 115 (20) 5083-5088; first published April 30, 2018. https://doi.org/10.1073/pnas.1717277115
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  Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice
  Hideyuki Yanai, Shiho Chiba, Sho Hangai, Kohei Kometani, Asuka Inoue, Yoshitaka Kimura, Takaya Abe, Hiroshi Kiyonari, Junko Nishio, Naoko Taguchi-Atarashi, Yu Mizushima, Hideo Negishi, Rudolf Grosschedl, and Tadatsugu Taniguchi
  
  PNAS May 15, 2018 115 (20) 5253-5258; first published April 30, 2018. https://doi.org/10.1073/pnas.1803936115
- Open Access
  Less immune activation following social stress in rural vs. urban participants raised with regular or no animal contact, respectively
  Till S. Böbel, Sascha B. Hackl, Dominik Langgartner, Marc N. Jarczok, Nicolas Rohleder, Graham A. Rook, Christopher A. Lowry, Harald Gündel, Christiane Waller, and Stefan O. Reber
  
  PNAS May 15, 2018 115 (20) 5259-5264; first published April 30, 2018. https://doi.org/10.1073/pnas.1719866115
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  Revealing the specificity of regulatory T cells in murine autoimmune diabetes
  Allyson Spence, Whitney Purtha, Janice Tam, Shen Dong, Youmin Kim, Chia-Hsin Ju, Teague Sterling, Maki Nakayama, William H. Robinson, Jeffrey A. Bluestone, Mark S. Anderson, and Qizhi Tang
  
  PNAS May 15, 2018 115 (20) 5265-5270; first published April 30, 2018. https://doi.org/10.1073/pnas.1715590115
Medical Sciences
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  Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy
  Xudong Liao, Yuyan Shen, Rongli Zhang, Keiki Sugi, Neelakantan T. Vasudevan, M. Amer Alaiti, David R. Sweet, Lin Zhou, Yulan Qing, Stanton L. Gerson, Chen Fu, Anthony Wynshaw-Boris, Rui Hu, Martin A. Schwartz, Hisashi Fujioka, Brian Richardson, Mark J. Cameron, Hiroki Hayashi, Jonathan S. Stamler, and Mukesh K. Jain
  
  PNAS May 15, 2018 115 (20) E4661-E4669; first published April 30, 2018. https://doi.org/10.1073/pnas.1720065115
Microbiology
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  Imaging mycobacterial growth and division with a fluorogenic probe
  Heather L. Hodges, Robert A. Brown, John A. Crooks, Douglas B. Weibel, and Laura L. Kiessling
  
  PNAS May 15, 2018 115 (20) 5271-5276; first published April 27, 2018. https://doi.org/10.1073/pnas.1720996115
Neuroscience
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  Structural homo- and heterosynaptic plasticity in mature and adult newborn rat hippocampal granule cells
  Tassilo Jungenitz, Marcel Beining, Tijana Radic, Thomas Deller, Hermann Cuntz, Peter Jedlicka, and Stephan W. Schwarzacher
  
  PNAS May 15, 2018 115 (20) E4670-E4679; first published April 30, 2018. https://doi.org/10.1073/pnas.1801889115
- Open Access
  Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress
  Inaugural Article
  
  Da Meng, Hui-quan Li, Karl Deisseroth, Stefan Leutgeb, and Nicholas C. Spitzer
  
  PNAS May 15, 2018 115 (20) 5064-5071; first published April 23, 2018. https://doi.org/10.1073/pnas.1801598115
  
  See companion article:
  QnAs with Nicholas C. Spitzer
  - Apr 23, 2018
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  Structured networks support sparse traveling waves in rodent somatosensory cortex
  Samat Moldakarimov, Maxim Bazhenov, Daniel E. Feldman, and Terrence J. Sejnowski
  
  PNAS May 15, 2018 115 (20) 5277-5282; first published April 30, 2018. https://doi.org/10.1073/pnas.1710202115
Pharmacology
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  Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation
  Weicang Wang, Jun Yang, Jianan Zhang, Yuxin Wang, Sung Hee Hwang, Weipeng Qi, Debin Wan, Daeyoung Kim, Jia Sun, Katherine Z. Sanidad, Haixia Yang, Yeonhwa Park, Jun-Yan Liu, Xinfeng Zhao, Xiaohui Zheng, Zhenhua Liu, Bruce D. Hammock, and Guodong Zhang
  
  PNAS May 15, 2018 115 (20) 5283-5288; first published May 1, 2018. https://doi.org/10.1073/pnas.1721711115
  
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  Proinflammatory enzyme soluble epoxide hydrolase bridges obesity to colonic inflammation and potential carcinogenesis
  - May 16, 2018
Physiology
- Open Access
  Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages
  From the Cover
  
  Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Bonne M. Thompson, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, and Christopher K. Glass
  
  PNAS May 15, 2018 115 (20) E4680-E4689; first published April 9, 2018. https://doi.org/10.1073/pnas.1714518115
  
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  Rational application of macrophage-specific LXR agonists avoids the pitfalls of SREBP-induced lipogenesis
  - Apr 30, 2018
Plant Biology
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  Loss of a highly conserved sterile alpha motif domain gene (WEEP) results in pendulous branch growth in peach trees
  Courtney A. Hollender, Thierry Pascal, Amy Tabb, Toto Hadiarto, Chinnathambi Srinivasan, Wanpeng Wang, Zhongchi Liu, Ralph Scorza, and Chris Dardick
  
  PNAS May 15, 2018 115 (20) E4690-E4699; first published April 30, 2018. https://doi.org/10.1073/pnas.1704515115
- Open Access
  Comparative genomics of the nonlegume Parasponia reveals insights into evolution of nitrogen-fixing rhizobium symbioses
  Robin van Velzen, Rens Holmer, Fengjiao Bu, Luuk Rutten, Arjan van Zeijl, Wei Liu, Luca Santuari, Qingqin Cao, Trupti Sharma, Defeng Shen, Yuda Roswanjaya, Titis A. K. Wardhani, Maryam Seifi Kalhor, Joelle Jansen, Johan van den Hoogen, Berivan Güngör, Marijke Hartog, Jan Hontelez, Jan Verver, Wei-Cai Yang, Elio Schijlen, Rimi Repin, Menno Schilthuizen, M. Eric Schranz, Renze Heidstra, Kana Miyata, Elena Fedorova, Wouter Kohlen, Ton Bisseling, Sandra Smit, and Rene Geurts
  
  PNAS May 15, 2018 115 (20) E4700-E4709; first published May 1, 2018. https://doi.org/10.1073/pnas.1721395115
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  MYB30 links ROS signaling, root cell elongation, and plant immune responses
  Kaho Mabuchi, Hiromasa Maki, Tomotaka Itaya, Takamasa Suzuki, Mika Nomoto, Satomi Sakaoka, Atsushi Morikami, Tetsuya Higashiyama, Yasuomi Tada, Wolfgang Busch, and Hironaka Tsukagoshi
  
  PNAS May 15, 2018 115 (20) E4710-E4719; first published April 30, 2018. https://doi.org/10.1073/pnas.1804233115
- Open Access
  FACT complex is required for DNA demethylation at heterochromatin during reproduction in Arabidopsis
  Jennifer M. Frost, M. Yvonne Kim, Guen Tae Park, Ping-Hung Hsieh, Miyuki Nakamura, Samuel J. H. Lin, Hyunjin Yoo, Jaemyung Choi, Yoko Ikeda, Tetsu Kinoshita, Yeonhee Choi, Daniel Zilberman, and Robert L. Fischer
  
  PNAS May 15, 2018 115 (20) E4720-E4729; first published April 30, 2018. https://doi.org/10.1073/pnas.1713333115
- Open Access
  Gravisensors in plant cells behave like an active granular liquid
  Antoine Bérut, Hugo Chauvet, Valérie Legué, Bruno Moulia, Olivier Pouliquen, and Yoël Forterre
  
  PNAS May 15, 2018 115 (20) 5123-5128; first published April 30, 2018. https://doi.org/10.1073/pnas.1801895115
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  Symbiotic root infections in Medicago truncatula require remorin-mediated receptor stabilization in membrane nanodomains
  Pengbo Liang, Thomas F. Stratil, Claudia Popp, Macarena Marín, Jessica Folgmann, Kirankumar S. Mysore, Jiangqi Wen, and Thomas Ott
  
  PNAS May 15, 2018 115 (20) 5289-5294; first published April 30, 2018. https://doi.org/10.1073/pnas.1721868115
Sustainability Science
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  Comparative terrestrial feed and land use of an aquaculture-dominant world
  Halley E. Froehlich, Claire A. Runge, Rebecca R. Gentry, Steven D. Gaines, and Benjamin S. Halpern
  
  PNAS May 15, 2018 115 (20) 5295-5300; first published April 30, 2018. https://doi.org/10.1073/pnas.1801692115

Corrections (Online Only)

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Correction for Jenkitkasemwong et al., SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice
PNAS May 15, 2018 115 (20) E4730; first published May 7, 2018. https://doi.org/10.1073/pnas.1806613115
You have access
Correction for Martin-Sanchez et al., TWEAK and RIPK1 mediate a second wave of cell death during AKI
PNAS May 15, 2018 115 (20) E4731; first published May 7, 2018. https://doi.org/10.1073/pnas.1806694115
You have access
Correction for Sanjak et al., Evidence of directional and stabilizing selection in contemporary humans
PNAS May 15, 2018 115 (20) E4732; first published May 7, 2018. https://doi.org/10.1073/pnas.1806837115

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