Proceedings of the National Academy of Sciences: 115 (21)

New Research In

May 22, 2018; vol. 115 no. 21

This Week in PNAS

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In This Issue
PNAS May 22, 2018 115 (21) 5301-5302; https://doi.org/10.1073/iti2118115

Letters (Online Only)

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Did human activity really trigger the late Holocene rainforest crisis in Central Africa?
Bernard Clist, Koen Bostoen, Pierre de Maret, Manfred K. H. Eggert, Alexa Höhn, Christophe Mbida Mindzié, Katharina Neumann, and Dirk Seidensticker

PNAS May 22, 2018 115 (21) E4733-E4734; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1805247115
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Reply to Clist et al.: Human activity is the most probable trigger of the late Holocene rainforest crisis in Western Central Africa
Yannick Garcin, Pierre Deschamps, Guillemette Ménot, Geoffroy de Saulieu, Enno Schefuß, David Sebag, Lydie M. Dupont, Richard Oslisly, Brian Brademann, Kevin G. Mbusnum, Jean-Michel Onana, Andrew A. Ako, Laura S. Epp, Rik Tjallingii, Manfred R. Strecker, Achim Brauer, and Dirk Sachse

PNAS May 22, 2018 115 (21) E4735-E4736; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1805582115
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Impact of sampling strategies and reconstruction protocols in nasal airflow simulations in fossil hominins
Andrej A. Evteev and Yann Heuzé

PNAS May 22, 2018 115 (21) E4737-E4738; published ahead of print May 4, 2018. https://doi.org/10.1073/pnas.1804197115
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Reply to Evteev and Heuzé: How to overcome the problem of modeling respiration departing from bony structures
S. de Azevedo, M. F. González, C. Cintas, V. Ramallo, M. Quinto-Sánchez, F. Márquez, T. Hünemeier, C. Paschetta, A. Ruderman, P. Navarro, B. A. Pazos, C. C. Silva de Cerqueira, O. Velan, F. Ramírez-Rozzi, N. Calvo, H. G. Castro, R. R. Paz, and R. González-José

PNAS May 22, 2018 115 (21) E4739-E4740; published ahead of print May 4, 2018. https://doi.org/10.1073/pnas.1804796115

Science and Culture

How science intersects with culture.

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Science and Culture: Artistic endeavors strive to save coral reefs
Front Matter
Carolyn Beans

PNAS May 22, 2018 115 (21) 5303-5305; https://doi.org/10.1073/pnas.1807178115

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Zebrafish assay forges new approach to drug discovery
Front Matter
Kim Smuga-Otto

PNAS May 22, 2018 115 (21) 5306-5308; https://doi.org/10.1073/pnas.1806440115

Retrospective

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Stephen Hawking (1942–2018): Toward a complete understanding of the universe
James Hartle

PNAS May 22, 2018 115 (21) 5309-5310; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1806196115

Commentaries

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Taming unruly chloride channel inhibitors with rational design
Rebecka J. Sepela and Jon T. Sack

PNAS May 22, 2018 115 (21) 5311-5313; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1805589115
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Uncertainty in long-run forecasts of quantities such as per capita gross domestic product
M. Granger Morgan

PNAS May 22, 2018 115 (21) 5314-5316; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1805767115
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New explanation for the longevity of social insect reproductives: Transposable element activity
Eric R. Lucas and Laurent Keller

PNAS May 22, 2018 115 (21) 5317-5318; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1806014115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS May 22, 2018 115 (21) 5319-5322; https://doi.org/10.1073/pnas.ss11521

Perspective

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Early fossil record of Euarthropoda and the Cambrian Explosion
Allison C. Daley, Jonathan B. Antcliffe, Harriet B. Drage, and Stephen Pates

PNAS May 22, 2018 115 (21) 5323-5331; published ahead of print May 22, 2018. https://doi.org/10.1073/pnas.1719962115

Physical Sciences

Applied Physical Sciences
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  Laterally confined growth of cells induces nuclear reprogramming in the absence of exogenous biochemical factors
  Bibhas Roy, Saradha Venkatachalapathy, Prasuna Ratna, Yejun Wang, Doorgesh Sharma Jokhun, Mallika Nagarajan, and G. V. Shivashankar
  
  PNAS May 22, 2018 115 (21) E4741-E4750; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1714770115
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  Phase-transition temperature suppression to achieve cubic GeTe and high thermoelectric performance by Bi and Mn codoping
  Zihang Liu, Jifeng Sun, Jun Mao, Hangtian Zhu, Wuyang Ren, Jingchao Zhou, Zhiming Wang, David J. Singh, Jiehe Sui, Ching-Wu Chu, and Zhifeng Ren
  
  PNAS May 22, 2018 115 (21) 5332-5337; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1802020115
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  Interferometric imaging of nonlocal electromechanical power transduction in ferroelectric domains
  Lu Zheng, Hui Dong, Xiaoyu Wu, Yen-Lin Huang, Wenbo Wang, Weida Wu, Zheng Wang, and Keji Lai
  
  PNAS May 22, 2018 115 (21) 5338-5342; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1722499115
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  Fully gapped d-wave superconductivity in CeCu₂Si₂
  Guiming Pang, Michael Smidman, Jinglei Zhang, Lin Jiao, Zongfa Weng, Emilian M. Nica, Ye Chen, Wenbing Jiang, Yongjun Zhang, Wu Xie, Hirale S. Jeevan, Hanoh Lee, Philipp Gegenwart, Frank Steglich, Qimiao Si, and Huiqiu Yuan
  
  PNAS May 22, 2018 115 (21) 5343-5347; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1720291115
Biophysics and Computational Biology
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  Physics of lumen growth
  Sabyasachi Dasgupta, Kapish Gupta, Yue Zhang, Virgile Viasnoff, and Jacques Prost
  
  PNAS May 22, 2018 115 (21) E4751-E4757; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1722154115
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  Developing a molecular dynamics force field for both folded and disordered protein states
  Paul Robustelli, Stefano Piana, and David E. Shaw
  
  PNAS May 22, 2018 115 (21) E4758-E4766; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800690115
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  Dynamic switching enables efficient bacterial colonization in flow
  Anerudh Kannan, Zhenbin Yang, Minyoung Kevin Kim, Howard A. Stone, and Albert Siryaporn
  
  PNAS May 22, 2018 115 (21) 5438-5443; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718813115
Chemistry
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  IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts
  Xiaomeng Shen, Shichen Shen, Jun Li, Qiang Hu, Lei Nie, Chengjian Tu, Xue Wang, David J. Poulsen, Benjamin C. Orsburn, Jianmin Wang, and Jun Qu
  
  PNAS May 22, 2018 115 (21) E4767-E4776; published ahead of print May 9, 2018. https://doi.org/10.1073/pnas.1800541115
- Open Access
  Molecular dynamics simulations of liquid silica crystallization
  Haiyang Niu, Pablo M. Piaggi, Michele Invernizzi, and Michele Parrinello
  
  PNAS May 22, 2018 115 (21) 5348-5352; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1803919115
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  Origin of radiation tolerance in amorphous Ge₂Sb₂Te₅ phase-change random-access memory material
  Konstantinos Konstantinou, Tae Hoon Lee, Felix C. Mocanu, and Stephen R. Elliott
  
  PNAS May 22, 2018 115 (21) 5353-5358; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800638115
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  Sequentially bridged graphene sheets with high strength, toughness, and electrical conductivity
  From the Cover
  
  Sijie Wan, Yuchen Li, Jiuke Mu, Ali E. Aliev, Shaoli Fang, Nicholas A. Kotov, Lei Jiang, Qunfeng Cheng, and Ray H. Baughman
  
  PNAS May 22, 2018 115 (21) 5359-5364; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719111115
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Rapid shift and millennial-scale variations in Holocene North Pacific Intermediate Water ventilation
  Lester Lembke-Jene, Ralf Tiedemann, Dirk Nürnberg, Xun Gong, and Gerrit Lohmann
  
  PNAS May 22, 2018 115 (21) 5365-5370; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1714754115
- Open Access
  Critical vaporization of MgSiO₃
  Bing Xiao and Lars Stixrude
  
  PNAS May 22, 2018 115 (21) 5371-5376; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719134115
Engineering
- Open Access
  Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity
  Theodoros P. Zanos, Harold A. Silverman, Todd Levy, Tea Tsaava, Emily Battinelli, Peter W. Lorraine, Jeffrey M. Ashe, Sangeeta S. Chavan, Kevin J. Tracey, and Chad E. Bouton
  
  PNAS May 22, 2018 115 (21) E4843-E4852; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719083115
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  Wireless, intraoral hybrid electronics for real-time quantification of sodium intake toward hypertension management
  Yongkuk Lee, Connor Howe, Saswat Mishra, Dong Sup Lee, Musa Mahmood, Matthew Piper, Youngbin Kim, Katie Tieu, Hun-Soo Byun, James P. Coffey, Mahdis Shayan, Youngjae Chun, Richard M. Costanzo, and Woon-Hong Yeo
  
  PNAS May 22, 2018 115 (21) 5377-5382; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719573115
Environmental Sciences
- Open Access
  Magnetic control of heterogeneous ice nucleation with nanophase magnetite: Biophysical and agricultural implications
  Atsuko Kobayashi, Masamoto Horikawa, Joseph L. Kirschvink, and Harry N. Golash
  
  PNAS May 22, 2018 115 (21) 5383-5388; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800294115
Mathematics
- Open Access
  Specificity and robustness of long-distance connections in weighted, interareal connectomes
  Richard F. Betzel and Danielle S. Bassett
  
  PNAS May 22, 2018 115 (21) E4880-E4889; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1720186115
Physics
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  Quantum oscillations in a biaxial pair density wave state
  M. R. Norman and J. C. Séamus Davis
  
  PNAS May 22, 2018 115 (21) 5389-5391; published ahead of print May 4, 2018. https://doi.org/10.1073/pnas.1803009115
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  Anomalous density fluctuations in a strange metal
  M. Mitrano, A. A. Husain, S. Vig, A. Kogar, M. S. Rak, S. I. Rubeck, J. Schmalian, B. Uchoa, J. Schneeloch, R. Zhong, G. D. Gu, and P. Abbamonte
  
  PNAS May 22, 2018 115 (21) 5392-5396; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1721495115
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  The geometric blueprint of perovskites
  Marina R. Filip and Feliciano Giustino
  
  PNAS May 22, 2018 115 (21) 5397-5402; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719179115
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  Flow-induced phase separation of active particles is controlled by boundary conditions
  Shashi Thutupalli, Delphine Geyer, Rajesh Singh, Ronojoy Adhikari, and Howard A. Stone
  
  PNAS May 22, 2018 115 (21) 5403-5408; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718807115
Sustainability Science
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  Uncertainty in forecasts of long-run economic growth
  From the Cover
  
  P. Christensen, K. Gillingham, and W. Nordhaus
  
  PNAS May 22, 2018 115 (21) 5409-5414; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1713628115

Biological Sciences

Agricultural Sciences
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  Importing food damages domestic environment: Evidence from global soybean trade
  Jing Sun, Harold Mooney, Wenbin Wu, Huajun Tang, Yuxin Tong, Zhenci Xu, Baorong Huang, Yeqing Cheng, Xinjun Yang, Dan Wei, Fusuo Zhang, and Jianguo Liu
  
  PNAS May 22, 2018 115 (21) 5415-5419; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718153115
- Open Access
  High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism
  Jaewook Chung, Xia Zhang, Bruce Collins, Renan B. Sper, Katherine Gleason, Sean Simpson, Sehwon Koh, Jeffrey Sommer, William L. Flowers, Robert M. Petters, and Jorge A. Piedrahita
  
  PNAS May 22, 2018 115 (21) 5420-5425; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1721630115
Applied Biological Sciences
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  IonStar enables high-precision, low-missing-data proteomics quantification in large biological cohorts
  Xiaomeng Shen, Shichen Shen, Jun Li, Qiang Hu, Lei Nie, Chengjian Tu, Xue Wang, David J. Poulsen, Benjamin C. Orsburn, Jianmin Wang, and Jun Qu
  
  PNAS May 22, 2018 115 (21) E4767-E4776; published ahead of print May 9, 2018. https://doi.org/10.1073/pnas.1800541115
Biochemistry
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  Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues
  Yanyan Yang, Ogun Adebali, Gang Wu, Christopher P. Selby, Yi-Ying Chiou, Naim Rashid, Jinchuan Hu, John B. Hogenesch, and Aziz Sancar
  
  PNAS May 22, 2018 115 (21) E4777-E4785; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1804493115
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  Inverted allosteric coupling between activation and inactivation gates in K⁺ channels
  Alain J. Labro, D. Marien Cortes, Cholpon Tilegenova, and Luis G. Cuello
  
  PNAS May 22, 2018 115 (21) 5426-5431; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800559115
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  Laboratory evolution of virus-like nucleocapsids from nonviral protein cages
  Naohiro Terasaka, Yusuke Azuma, and Donald Hilvert
  
  PNAS May 22, 2018 115 (21) 5432-5437; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800527115
Biophysics and Computational Biology
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  Cotranslocational processing of the protein substrate calmodulin by an AAA+ unfoldase occurs via unfolding and refolding intermediates
  Rafal Augustyniak and Lewis E. Kay
  
  PNAS May 22, 2018 115 (21) E4786-E4795; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1721811115
- Open Access
  Systematic approach for dissecting the molecular mechanisms of transcriptional regulation in bacteria
  Nathan M. Belliveau, Stephanie L. Barnes, William T. Ireland, Daniel L. Jones, Michael J. Sweredoski, Annie Moradian, Sonja Hess, Justin B. Kinney, and Rob Phillips
  
  PNAS May 22, 2018 115 (21) E4796-E4805; published ahead of print May 4, 2018. https://doi.org/10.1073/pnas.1722055115
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  Dynamic switching enables efficient bacterial colonization in flow
  Anerudh Kannan, Zhenbin Yang, Minyoung Kevin Kim, Howard A. Stone, and Albert Siryaporn
  
  PNAS May 22, 2018 115 (21) 5438-5443; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718813115
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  Real-time observation of DNA target interrogation and product release by the RNA-guided endonuclease CRISPR Cpf1 (Cas12a)
  Digvijay Singh, John Mallon, Anustup Poddar, Yanbo Wang, Ramreddy Tippana, Olivia Yang, Scott Bailey, and Taekjip Ha
  
  PNAS May 22, 2018 115 (21) 5444-5449; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718686115
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  Ion-triggered selectivity in bacterial sodium channels
  Simone Furini and Carmen Domene
  
  PNAS May 22, 2018 115 (21) 5450-5455; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1722516115
- Open Access
  Polypentagonal ice-like water networks emerge solely in an activity-improved variant of ice-binding protein
  Sheikh Mahatabuddin, Daichi Fukami, Tatsuya Arai, Yoshiyuki Nishimiya, Rumi Shimizu, Chie Shibazaki, Hidemasa Kondo, Motoyasu Adachi, and Sakae Tsuda
  
  PNAS May 22, 2018 115 (21) 5456-5461; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800635115
Cell Biology
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  STXBP4 regulates APC/C-mediated p63 turnover and drives squamous cell carcinogenesis
  Susumu Rokudai, Yingchun Li, Yukihiro Otaka, Michiru Fujieda, David M. Owens, Angela M. Christiano, Masahiko Nishiyama, and Carol Prives
  
  PNAS May 22, 2018 115 (21) E4806-E4814; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718546115
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  Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism
  Ryan J. Davis, Mehmet Gönen, Daciana H. Margineantu, Shlomo Handeli, Jherek Swanger, Pia Hoellerbauer, Patrick J. Paddison, Haiwei Gu, Daniel Raftery, Jonathan E. Grim, David M. Hockenbery, Adam A. Margolin, and Bruce E. Clurman
  
  PNAS May 22, 2018 115 (21) 5462-5467; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718338115
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  Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration
  Julian Esteve-Rudd, Roni A. Hazim, Tanja Diemer, Antonio E. Paniagua, Stefanie Volland, Ankita Umapathy, and David S. Williams
  
  PNAS May 22, 2018 115 (21) 5468-5473; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1709211115
Developmental Biology
- Open Access
  Embryonic regeneration by relocalization of the Spemann organizer during twinning in Xenopus
  Yuki Moriyama and Edward M. De Robertis
  
  PNAS May 22, 2018 115 (21) E4815-E4822; published ahead of print April 23, 2018. https://doi.org/10.1073/pnas.1802749115
- Open Access
  ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling
  Abigail Harris, Pam Siggers, Silvia Corrochano, Nick Warr, Danielle Sagar, Daniel T. Grimes, Makoto Suzuki, Rebecca D. Burdine, Feng Cong, Bon-Kyoung Koo, Hans Clevers, Isabelle Stévant, Serge Nef, Sara Wells, Raja Brauner, Bochra Ben Rhouma, Neïla Belguith, Caroline Eozenou, Joelle Bignon-Topalovic, Anu Bashamboo, Ken McElreavey, and Andy Greenfield
  
  PNAS May 22, 2018 115 (21) 5474-5479; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1801223115
Ecology
- Open Access
  Divergent drivers of leaf trait variation within species, among species, and among functional groups
  Jeanne L. D. Osnas, Masatoshi Katabuchi, Kaoru Kitajima, S. Joseph Wright, Peter B. Reich, Sunshine A. Van Bael, Nathan J. B. Kraft, Mirna J. Samaniego, Stephen W. Pacala, and Jeremy W. Lichstein
  
  PNAS May 22, 2018 115 (21) 5480-5485; published ahead of print May 3, 2018. https://doi.org/10.1073/pnas.1803989115
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  Recurrent bridgehead effects accelerate global alien ant spread
  Cleo Bertelsmeier, Sébastien Ollier, Andrew M. Liebhold, Eckehard G. Brockerhoff, Darren Ward, and Laurent Keller
  
  PNAS May 22, 2018 115 (21) 5486-5491; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1801990115
Environmental Sciences
- Open Access
  Magnetic control of heterogeneous ice nucleation with nanophase magnetite: Biophysical and agricultural implications
  Atsuko Kobayashi, Masamoto Horikawa, Joseph L. Kirschvink, and Harry N. Golash
  
  PNAS May 22, 2018 115 (21) 5383-5388; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800294115
Evolution
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  Strategic investment explains patterns of cooperation and cheating in a microbe
  Philip G. Madgwick, Balint Stewart, Laurence J. Belcher, Christopher R. L. Thompson, and Jason B. Wolf
  
  PNAS May 22, 2018 115 (21) E4823-E4832; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1716087115
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  Linked genetic variation and not genome structure causes widespread differential expression associated with chromosomal inversions
  Iskander Said, Ashley Byrne, Victoria Serrano, Charis Cardeno, Christopher Vollmers, and Russell Corbett-Detig
  
  PNAS May 22, 2018 115 (21) 5492-5497; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1721275115
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  Artificial selection reveals sex differences in the genetic basis of sexual attractiveness
  Thomas P. Gosden, Adam J. Reddiex, and Stephen F. Chenoweth
  
  PNAS May 22, 2018 115 (21) 5498-5503; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1720368115
- Open Access
  Longevity and transposon defense, the case of termite reproductives
  From the Cover
  
  Daniel Elsner, Karen Meusemann, and Judith Korb
  
  PNAS May 22, 2018 115 (21) 5504-5509; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1804046115
- Open Access
  Acquisition of virulence genes by a carrier strain gave rise to the ongoing epidemics of meningococcal disease in West Africa
  Ola Brønstad Brynildsrud, Vegard Eldholm, Jon Bohlin, Kennedy Uadiale, Stephen Obaro, and Dominique A. Caugant
  
  PNAS May 22, 2018 115 (21) 5510-5515; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1802298115
Genetics
- Open Access
  Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA
  Xingya Xu, Ryuta Kanai, Norihiko Nakazawa, Li Wang, Chikashi Toyoshima, and Mitsuhiro Yanagida
  
  PNAS May 22, 2018 115 (21) E4833-E4842; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1803564115
- Open Access
  Precise detection of de novo single nucleotide variants in human genomes
  Laura Gómez-Romero, Kim Palacios-Flores, José Reyes, Delfino García, Margareta Boege, Guillermo Dávila, Margarita Flores, Michael C. Schatz, and Rafael Palacios
  
  PNAS May 22, 2018 115 (21) 5516-5521; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1802244115
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  Reducing resistance allele formation in CRISPR gene drive
  From the Cover
  
  Jackson Champer, Jingxian Liu, Suh Yeon Oh, Riona Reeves, Anisha Luthra, Nathan Oakes, Andrew G. Clark, and Philipp W. Messer
  
  PNAS May 22, 2018 115 (21) 5522-5527; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1720354115
Immunology and Inflammation
- Open Access
  Identification of cytokine-specific sensory neural signals by decoding murine vagus nerve activity
  Theodoros P. Zanos, Harold A. Silverman, Todd Levy, Tea Tsaava, Emily Battinelli, Peter W. Lorraine, Jeffrey M. Ashe, Sangeeta S. Chavan, Kevin J. Tracey, and Chad E. Bouton
  
  PNAS May 22, 2018 115 (21) E4843-E4852; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719083115
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  Biochemically altered myelin triggers autoimmune demyelination
  Andrew V. Caprariello, James A. Rogers, Megan L. Morgan, Vahid Hoghooghi, Jason R. Plemel, Adam Koebel, Shigeki Tsutsui, Jeffrey F. Dunn, Lakshmi P. Kotra, Shalina S. Ousman, V. Wee Yong, and Peter K. Stys
  
  PNAS May 22, 2018 115 (21) 5528-5533; published ahead of print May 4, 2018. https://doi.org/10.1073/pnas.1721115115
Medical Sciences
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  Osmotic stabilization prevents cochlear synaptopathy after blast trauma
  Jinkyung Kim, Anping Xia, Nicolas Grillet, Brian E. Applegate, and John S. Oghalai
  
  PNAS May 22, 2018 115 (21) E4853-E4860; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1720121115
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  Modeling combination therapy for breast cancer with BET and immune checkpoint inhibitors
  Xiulan Lai, Andrew Stiff, Megan Duggan, Robert Wesolowski, William E. Carson III, and Avner Friedman
  
  PNAS May 22, 2018 115 (21) 5534-5539; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1721559115
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  Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome
  Laura Kervezee, Marc Cuesta, Nicolas Cermakian, and Diane B. Boivin
  
  PNAS May 22, 2018 115 (21) 5540-5545; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1720719115
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  Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation
  Yu-Che Cheng and Sheau-Yann Shieh
  
  PNAS May 22, 2018 115 (21) 5546-5551; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719856115
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  Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine
  Weiwei Lei, Wenwen Ren, Makoto Ohmoto, Joseph F. Urban Jr., Ichiro Matsumoto, Robert F. Margolskee, and Peihua Jiang
  
  PNAS May 22, 2018 115 (21) 5552-5557; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1720758115
Microbiology
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  P_II-like signaling protein SbtB links cAMP sensing with cyanobacterial inorganic carbon response
  Khaled A. Selim, Florian Haase, Marcus D. Hartmann, Martin Hagemann, and Karl Forchhammer
  
  PNAS May 22, 2018 115 (21) E4861-E4869; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1803790115
- Open Access
  Periplasmic depolymerase provides insight into ABC transporter-dependent secretion of bacterial capsular polysaccharides
  Sean D. Liston, Stephen A. McMahon, Audrey Le Bas, Michael D. L. Suits, James H. Naismith, and Chris Whitfield
  
  PNAS May 22, 2018 115 (21) E4870-E4879; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1801336115
- Open Access
  Structural basis for Acinetobacter baumannii biofilm formation
  Natalia Pakharukova, Minna Tuittila, Sari Paavilainen, Henri Malmi, Olena Parilova, Susann Teneberg, Stefan D. Knight, and Anton V. Zavialov
  
  PNAS May 22, 2018 115 (21) 5558-5563; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800961115
- Open Access
  Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion
  Philippe Herman-Bausier, Cristina Labate, Aisling M. Towell, Sylvie Derclaye, Joan A. Geoghegan, and Yves F. Dufrêne
  
  PNAS May 22, 2018 115 (21) 5564-5569; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1718104115
Neuroscience
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  Specificity and robustness of long-distance connections in weighted, interareal connectomes
  Richard F. Betzel and Danielle S. Bassett
  
  PNAS May 22, 2018 115 (21) E4880-E4889; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1720186115
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  Dopamine receptors mediate strategy abandoning via modulation of a specific prelimbic cortex–nucleus accumbens pathway in mice
  Qiaoling Cui, Qian Li, Hongyan Geng, Lei Chen, Nancy Y. Ip, Ya Ke, and Wing-Ho Yung
  
  PNAS May 22, 2018 115 (21) E4890-E4899; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1717106115
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  Ca²⁺-activated Cl current predominates in threshold response of mouse olfactory receptor neurons
  Rong-Chang Li, Chih-Chun Lin, Xiaozhi Ren, Jingjing Sherry Wu, Laurie L. Molday, Robert S. Molday, and King-Wai Yau
  
  PNAS May 22, 2018 115 (21) 5570-5575; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1803443115
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  LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease
  Maria Nguyen and Dimitri Krainc
  
  PNAS May 22, 2018 115 (21) 5576-5581; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1717590115
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  Transcriptomic context of DRD1 is associated with prefrontal activity and behavior during working memory
  Leonardo Fazio, Giulio Pergola, Marco Papalino, Pasquale Di Carlo, Anna Monda, Barbara Gelao, Nicola Amoroso, Sabina Tangaro, Antonio Rampino, Teresa Popolizio, Alessandro Bertolino, and Giuseppe Blasi
  
  PNAS May 22, 2018 115 (21) 5582-5587; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1717135115
- Open Access
  Flight motor networks modulate primary olfactory processing in the moth Manduca sexta
  Phillip D. Chapman, Rex Burkland, Samual P. Bradley, Benjamin Houot, Victoria Bullman, Andrew M. Dacks, and Kevin C. Daly
  
  PNAS May 22, 2018 115 (21) 5588-5593; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1722379115
- Open Access
  Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses
  Nordine Helassa, Céline D. Dürst, Catherine Coates, Silke Kerruth, Urwa Arif, Christian Schulze, J. Simon Wiegert, Michael Geeves, Thomas G. Oertner, and Katalin Török
  
  PNAS May 22, 2018 115 (21) 5594-5599; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1720648115
Pharmacology
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  A selective class of inhibitors for the CLC-Ka chloride ion channel
  From the Cover
  
  Anna K. Koster, Chase A. P. Wood, Rhiannon Thomas-Tran, Tanmay S. Chavan, Jonas Almqvist, Kee-Hyun Choi, J. Du Bois, and Merritt Maduke
  
  PNAS May 22, 2018 115 (21) E4900-E4909; published ahead of print April 18, 2018. https://doi.org/10.1073/pnas.1720584115
Physiology
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  Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease
  Juanjuan Zhao, Katherine Lupino, Benjamin J. Wilkins, Chengxiang Qiu, Jian Liu, Yasuhiro Omura, Amanda L. Allred, Caitlin McDonald, Katalin Susztak, Grant D. Barish, and Liming Pei
  
  PNAS May 22, 2018 115 (21) E4910-E4919; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1804965115
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  Farnesoid X receptor is essential for the survival of renal medullary collecting duct cells under hypertonic stress
  Sujuan Xu, Shizheng Huang, Zhilin Luan, Tingyue Chen, Yuanyi Wei, Miaomiao Xing, Yaqing Li, Chunxiu Du, Bing Wang, Feng Zheng, Nanping Wang, Youfei Guan, Jan-Åke Gustafsson, and Xiaoyan Zhang
  
  PNAS May 22, 2018 115 (21) 5600-5605; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1803945115
Plant Biology
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  N-hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis
  Yun-Chu Chen, Eric C. Holmes, Jakub Rajniak, Jung-Gun Kim, Sandy Tang, Curt R. Fischer, Mary Beth Mudgett, and Elizabeth S. Sattely
  
  PNAS May 22, 2018 115 (21) E4920-E4929; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1805291115
- Open Access
  Time-evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis
  Hyo Jung Kim, Ji-Hwan Park, Jingil Kim, Jung Ju Kim, Sunghyun Hong, Jeongsik Kim, Jin Hee Kim, Hye Ryun Woo, Changbong Hyeon, Pyung Ok Lim, Hong Gil Nam, and Daehee Hwang
  
  PNAS May 22, 2018 115 (21) E4930-E4939; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1721523115
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  Diurnal down-regulation of ethylene biosynthesis mediates biomass heterosis
  Qingxin Song, Atsumi Ando, Dongqing Xu, Lei Fang, Tianzhen Zhang, Enamul Huq, Hong Qiao, Xing Wang Deng, and Z. Jeffrey Chen
  
  PNAS May 22, 2018 115 (21) 5606-5611; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1722068115
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  Rewiring of auxin signaling under persistent shade
  Ornella Pucciariello, Martina Legris, Cecilia Costigliolo Rojas, María José Iglesias, Carlos Esteban Hernando, Carlos Dezar, Martín Vazquez, Marcelo J. Yanovsky, Scott A. Finlayson, Salomé Prat, and Jorge J. Casal
  
  PNAS May 22, 2018 115 (21) 5612-5617; published ahead of print May 3, 2018. https://doi.org/10.1073/pnas.1721110115
Systems Biology
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  Codon usage of highly expressed genes affects proteome-wide translation efficiency
  Idan Frumkin, Marc J. Lajoie, Christopher J. Gregg, Gil Hornung, George M. Church, and Yitzhak Pilpel
  
  PNAS May 22, 2018 115 (21) E4940-E4949; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1719375115

Corrections (Online Only)

You have access
Correction for Ishikawa et al., Ion-beam irradiation, gene identification, and marker-assisted breeding in the development of low-cadmium rice
PNAS May 22, 2018 115 (21) E4950-E4951; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1806782115
You have access
Correction for Xu et al., Drought delays development of the sorghum root microbiome and enriches for monoderm bacteria
PNAS May 22, 2018 115 (21) E4952; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1807275115

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