Proceedings of the National Academy of Sciences: 115 (22)

New Research In

May 29, 2018; vol. 115 no. 22

This Week in PNAS

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In This Issue
PNAS May 29, 2018 115 (22) 5619-5620; https://doi.org/10.1073/iti2218115

Letters (Online Only)

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Water dynamics in concentrated electrolytes: Local ion effect on hydrogen-bond jumps rather than collective coupling to ion clusters
Guillaume Stirnemann, Pavel Jungwirth, and Damien Laage

PNAS May 29, 2018 115 (22) E4953-E4954; published ahead of print May 10, 2018. https://doi.org/10.1073/pnas.1803988115
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Reply to Stirnemann et al.: Frame retardation is the key reason behind the general slowdown of water reorientation dynamics in concentrated electrolytes
Qiang Zhang, TianMin Wu, Chen Chen, Shaul Mukamel, and Wei Zhuang

PNAS May 29, 2018 115 (22) E4955-E4956; published ahead of print May 10, 2018. https://doi.org/10.1073/pnas.1805682115
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Little evidence for the vocal similarity hypothesis
Jack Goffinet

PNAS May 29, 2018 115 (22) E4957; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1804577115
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Reply to Goffinet: In consonance, old ideas die hard
Daniel L. Bowling, Dale Purves, and Kamraan Z. Gill

PNAS May 29, 2018 115 (22) E4958-E4959; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1805570115

Core Concepts

A brief introduction to emerging topics in science.

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Core Concept: “Twisted” light beams promise an optical revolution
Front Matter
Adam Mann

PNAS May 29, 2018 115 (22) 5621-5623; https://doi.org/10.1073/pnas.1805768115

Retrospective

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Retrospective of Charles Pence Slichter (NAS 1967)
Gordon Baym

PNAS May 29, 2018 115 (22) 5624-5625; published ahead of print April 30, 2018. https://doi.org/10.1073/pnas.1806115115

Commentaries

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The promise of genes for understanding cause and effect
Dalton Conley and Simone Zhang

PNAS May 29, 2018 115 (22) 5626-5628; published ahead of print May 21, 2018. https://doi.org/10.1073/pnas.1805585115
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Root-exuded coumarin shapes the root microbiome
Derek S. Lundberg and Paulo J. P. L. Teixeira

PNAS May 29, 2018 115 (22) 5629-5631; published ahead of print May 15, 2018. https://doi.org/10.1073/pnas.1805944115
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Biological electron transport goes the extra mile
Gemma Reguera

PNAS May 29, 2018 115 (22) 5632-5634; published ahead of print May 16, 2018. https://doi.org/10.1073/pnas.1806580115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS May 29, 2018 115 (22) 5635-5640; https://doi.org/10.1073/pnas.ss11522

Physical Sciences

Applied Physical Sciences
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  Why we need to look beyond the glass transition temperature to characterize the dynamics of thin supported polymer films
  Wengang Zhang, Jack F. Douglas, and Francis W. Starr
  
  PNAS May 29, 2018 115 (22) 5641-5646; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1722024115
Biophysics and Computational Biology
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  Conformations of peptoids in nanosheets result from the interplay of backbone energetics and intermolecular interactions
  John R. Edison, Ryan K. Spencer, Glenn L. Butterfoss, Benjamin C. Hudson, Allon I. Hochbaum, Anant K. Paravastu, Ronald N. Zuckermann, and Stephen Whitelam
  
  PNAS May 29, 2018 115 (22) 5647-5651; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800397115
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  Ultrafast nonthermal heating of water initiated by an X-ray Free-Electron Laser
  Kenneth R. Beyerlein, H. Olof Jönsson, Roberto Alonso-Mori, Andrew Aquila, Saša Bajt, Anton Barty, Richard Bean, Jason E. Koglin, Marc Messerschmidt, Davide Ragazzon, Dimosthenis Sokaras, Garth J. Williams, Stefan Hau-Riege, Sébastien Boutet, Henry N. Chapman, Nicuşor Tîmneanu, and Carl Caleman
  
  PNAS May 29, 2018 115 (22) 5652-5657; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1711220115
Chemistry
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  Calcium, conformational selection, and redox-active tyrosine YZ in the photosynthetic oxygen-evolving cluster
  Zhanjun Guo, Jiayuan He, and Bridgette A. Barry
  
  PNAS May 29, 2018 115 (22) 5658-5663; published ahead of print May 11, 2018. https://doi.org/10.1073/pnas.1800758115
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  Heterometallic Ru–Pt metallacycle for two-photon photodynamic therapy
  Zhixuan Zhou, Jiangping Liu, Thomas W. Rees, Heng Wang, Xiaopeng Li, Hui Chao, and Peter J. Stang
  
  PNAS May 29, 2018 115 (22) 5664-5669; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1802012115
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  An operando X-ray diffraction study of chloroaluminate anion-graphite intercalation in aluminum batteries
  Chun-Jern Pan, Chunze Yuan, Guanzhou Zhu, Qian Zhang, Chen-Jui Huang, Meng-Chang Lin, Michael Angell, Bing-Joe Hwang, Payam Kaghazchi, and Hongjie Dai
  
  PNAS May 29, 2018 115 (22) 5670-5675; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1803576115
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  High-capacity rechargeable batteries based on deeply cyclable lithium metal anodes
  Qiuwei Shi, Yiren Zhong, Min Wu, Hongzhi Wang, and Hailiang Wang
  
  PNAS May 29, 2018 115 (22) 5676-5680; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1803634115
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  Approach to classify, separate, and enrich objects in groups using ensemble sorting
  Rebecca Turk-MacLeod, Alon Henson, Marc Rodriguez-Garcia, Graham M. Gibson, Gerardo Aragon Camarasa, Dario Caramelli, Miles J. Padgett, and Leroy Cronin
  
  PNAS May 29, 2018 115 (22) 5681-5685; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1721929115
- Open Access
  The glycolipid GM1 reshapes asymmetric biomembranes and giant vesicles by curvature generation
  Raktim Dasgupta, Markus S. Miettinen, Nico Fricke, Reinhard Lipowsky, and Rumiana Dimova
  
  PNAS May 29, 2018 115 (22) 5756-5761; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1722320115
Earth, Atmospheric, and Planetary Sciences
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  Pacing of Paleozoic macroevolutionary rates by Milankovitch grand cycles
  James S. Crampton, Stephen R. Meyers, Roger A. Cooper, Peter M. Sadler, Michael Foote, and David Harte
  
  PNAS May 29, 2018 115 (22) 5686-5691; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1714342115
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  The role of the permanent wilting point in controlling the spatial distribution of precipitation
  Cathy Hohenegger and Bjorn Stevens
  
  PNAS May 29, 2018 115 (22) 5692-5697; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1718842115
Engineering
- Open Access
  Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing
  Christopher T. Johnson, James A. Wroe, Rachit Agarwal, Karen E. Martin, Robert E. Guldberg, Rodney M. Donlan, Lars F. Westblade, and Andrés J. García
  
  PNAS May 29, 2018 115 (22) E4960-E4969; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1801013115
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  Harnessing bistability for directional propulsion of soft, untethered robots
  Tian Chen, Osama R. Bilal, Kristina Shea, and Chiara Daraio
  
  PNAS May 29, 2018 115 (22) 5698-5702; published ahead of print May 15, 2018. https://doi.org/10.1073/pnas.1800386115
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  Additive-free carbon nanotube dispersions, pastes, gels, and doughs in cresols
  From the Cover
  
  Kevin Chiou, Segi Byun, Jaemyung Kim, and Jiaxing Huang
  
  PNAS May 29, 2018 115 (22) 5703-5708; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800298115
Environmental Sciences
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  Lead pollution recorded in Greenland ice indicates European emissions tracked plagues, wars, and imperial expansion during antiquity
  Joseph R. McConnell, Andrew I. Wilson, Andreas Stohl, Monica M. Arienzo, Nathan J. Chellman, Sabine Eckhardt, Elisabeth M. Thompson, A. Mark Pollard, and Jørgen Peder Steffensen
  
  PNAS May 29, 2018 115 (22) 5726-5731; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1721818115
Physics
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  High-temperature superconductivity using a model of hydrogen bonds
  Daniel Kaplan and Yoseph Imry
  
  PNAS May 29, 2018 115 (22) 5709-5713; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1803767115
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  Weak Galilean invariance as a selection principle for coarse-grained diffusive models
  Andrea Cairoli, Rainer Klages, and Adrian Baule
  
  PNAS May 29, 2018 115 (22) 5714-5719; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1717292115

Biological Sciences

Anthropology
- Open Access
  Endocast morphology of Homo naledi from the Dinaledi Chamber, South Africa
  Ralph L. Holloway, Shawn D. Hurst, Heather M. Garvin, P. Thomas Schoenemann, William B. Vanti, Lee R. Berger, and John Hawks
  
  PNAS May 29, 2018 115 (22) 5738-5743; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1720842115
Applied Biological Sciences
- Open Access
  Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing
  Christopher T. Johnson, James A. Wroe, Rachit Agarwal, Karen E. Martin, Robert E. Guldberg, Rodney M. Donlan, Lars F. Westblade, and Andrés J. García
  
  PNAS May 29, 2018 115 (22) E4960-E4969; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1801013115
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  Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis
  Linan Xie, Liwen Zhang, Chen Wang, Xiaojing Wang, Ya-ming Xu, Hefen Yu, Ping Wu, Shenglan Li, Lida Han, A. A. Leslie Gunatilaka, Xiaoyi Wei, Min Lin, István Molnár, and Yuquan Xu
  
  PNAS May 29, 2018 115 (22) E4980-E4989; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1716046115
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  Isolation of state-dependent monoclonal antibodies against the 12-transmembrane domain glucose transporter 4 using virus-like particles
  David F. Tucker, Jonathan T. Sullivan, Kimberly-Anne Mattia, Christine R. Fisher, Trevor Barnes, Manu N. Mabila, Rona Wilf, Chidananda Sulli, Meghan Pitts, Riley J. Payne, Moniquetta Hall, Duncan Huston-Paterson, Xiaoxiang Deng, Edgar Davidson, Sharon H. Willis, Benjamin J. Doranz, Ross Chambers, and Joseph B. Rucker
  
  PNAS May 29, 2018 115 (22) E4990-E4999; published ahead of print May 16, 2018. https://doi.org/10.1073/pnas.1716788115
Biochemistry
- Open Access
  Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin
  Hiroaki Mizuno, Kotaro Tanaka, Sawako Yamashiro, Akihiro Narita, and Naoki Watanabe
  
  PNAS May 29, 2018 115 (22) E5000-E5007; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1803415115
- Open Access
  Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides
  Matthias C. Truttmann, David Pincus, and Hidde L. Ploegh
  
  PNAS May 29, 2018 115 (22) E5008-E5017; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1801989115
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  Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein
  Karin Schmidt, Bernd R. Gardill, Alina Kern, Peter Kirchweger, Michael Börsch, and Yves A. Muller
  
  PNAS May 29, 2018 115 (22) 5744-5749; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1716666115
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  Elastic coupling power stroke mechanism of the F₁-ATPase molecular motor
  James L. Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, and Wayne D. Frasch
  
  PNAS May 29, 2018 115 (22) 5750-5755; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1803147115
Biophysics and Computational Biology
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  Conformations of peptoids in nanosheets result from the interplay of backbone energetics and intermolecular interactions
  John R. Edison, Ryan K. Spencer, Glenn L. Butterfoss, Benjamin C. Hudson, Allon I. Hochbaum, Anant K. Paravastu, Ronald N. Zuckermann, and Stephen Whitelam
  
  PNAS May 29, 2018 115 (22) 5647-5651; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800397115
- Open Access
  The glycolipid GM1 reshapes asymmetric biomembranes and giant vesicles by curvature generation
  Raktim Dasgupta, Markus S. Miettinen, Nico Fricke, Reinhard Lipowsky, and Rumiana Dimova
  
  PNAS May 29, 2018 115 (22) 5756-5761; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1722320115
- Open Access
  Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti
  Hamid Motallebzadeh, Joris A. M. Soons, and Sunil Puria
  
  PNAS May 29, 2018 115 (22) 5762-5767; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1720979115
Developmental Biology
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  Chemokine C-C motif ligand 33 is a key regulator of teleost fish barbel development
  Tao Zhou, Ning Li, Yulin Jin, Qifan Zeng, Wendy Prabowo, Yang Liu, Changxu Tian, Lisui Bao, Shikai Liu, Zihao Yuan, Qiang Fu, Sen Gao, Dongya Gao, Rex Dunham, Neil H. Shubin, and Zhanjiang Liu
  
  PNAS May 29, 2018 115 (22) E5018-E5027; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1718603115
Ecology
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  Effects of the hippopotamus on the chemistry and ecology of a changing watershed
  Keenan Stears, Douglas J. McCauley, Jacques C. Finlay, James Mpemba, Ian T. Warrington, Benezeth M. Mutayoba, Mary E. Power, Todd E. Dawson, and Justin S. Brashares
  
  PNAS May 29, 2018 115 (22) E5028-E5037; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800407115
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  Transhemispheric ecosystem disservices of pink salmon in a Pacific Ocean macrosystem
  Alan M. Springer, Gus B. van Vliet, Natalie Bool, Mike Crowley, Peter Fullagar, Mary-Anne Lea, Ross Monash, Cassandra Price, Caitlin Vertigan, and Eric J. Woehler
  
  PNAS May 29, 2018 115 (22) E5038-E5045; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1720577115
Evolution
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  The genome-wide rate and spectrum of spontaneous mutations differ between haploid and diploid yeast
  Nathaniel P. Sharp, Linnea Sandell, Christopher G. James, and Sarah P. Otto
  
  PNAS May 29, 2018 115 (22) E5046-E5055; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1801040115
- Open Access
  Selection and environmental adaptation along a path to speciation in the Tibetan frog Nanorana parkeri
  Guo-Dong Wang, Bao-Lin Zhang, Wei-Wei Zhou, Yong-Xin Li, Jie-Qiong Jin, Yong Shao, He-chuan Yang, Yan-Hu Liu, Fang Yan, Hong-Man Chen, Li Jin, Feng Gao, Yaoguang Zhang, Haipeng Li, Bingyu Mao, Robert W. Murphy, David B. Wake, Ya-Ping Zhang, and Jing Che
  
  PNAS May 29, 2018 115 (22) E5056-E5065; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1716257115
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  Pacing of Paleozoic macroevolutionary rates by Milankovitch grand cycles
  James S. Crampton, Stephen R. Meyers, Roger A. Cooper, Peter M. Sadler, Michael Foote, and David Harte
  
  PNAS May 29, 2018 115 (22) 5686-5691; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1714342115
Genetics
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  PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids
  Changlong Liu, Carolyn E. Banister, Charles C. Weige, Diego Altomare, Joseph H. Richardson, Carlo M. Contreras, and Phillip J. Buckhaults
  
  PNAS May 29, 2018 115 (22) E5066-E5075; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1802902115
Immunology and Inflammation
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  A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage
  Vu L. Ngo, Hirohito Abo, Estera Maxim, Akihito Harusato, Duke Geem, Oscar Medina-Contreras, Didier Merlin, Andrew T. Gewirtz, Asma Nusrat, and Timothy L. Denning
  
  PNAS May 29, 2018 115 (22) E5076-E5085; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1718902115
Medical Sciences
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  Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma
  Liang Xu, Ye Chen, Anand Mayakonda, Lynnette Koh, Yuk Kien Chong, Dennis L. Buckley, Edwin Sandanaraj, See Wee Lim, Ruby Yu-Tong Lin, Xin-Yu Ke, Mo-Li Huang, Jianxiang Chen, Wendi Sun, Ling-Zhi Wang, Boon Cher Goh, Huy Q. Dinh, Dennis Kappei, Georg E. Winter, Ling-Wen Ding, Beng Ti Ang, Benjamin P. Berman, James E. Bradner, Carol Tang, and H. Phillip Koeffler
  
  PNAS May 29, 2018 115 (22) E5086-E5095; published ahead of print May 15, 2018. https://doi.org/10.1073/pnas.1712363115
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  Distinct macrophage populations direct inflammatory versus physiological changes in adipose tissue
  David A. Hill, Hee-Woong Lim, Yong Hoon Kim, Wesley Y. Ho, Yee Hoon Foong, Victoria L. Nelson, Hoang C. B. Nguyen, Kavya Chegireddy, Jihoon Kim, Andreas Habertheuer, Prashanth Vallabhajosyula, Taku Kambayashi, Kyoung-Jae Won, and Mitchell A. Lazar
  
  PNAS May 29, 2018 115 (22) E5096-E5105; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1802611115
- Open Access
  Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing
  Kun Sun, Peiyong Jiang, Ada I. C. Wong, Yvonne K. Y. Cheng, Suk Hang Cheng, Haiqiang Zhang, K. C. Allen Chan, Tak Y. Leung, Rossa W. K. Chiu, and Y. M. Dennis Lo
  
  PNAS May 29, 2018 115 (22) E5106-E5114; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1804134115
- Open Access
  Sequencing-based counting and size profiling of plasma Epstein–Barr virus DNA enhance population screening of nasopharyngeal carcinoma
  W. K. Jacky Lam, Peiyong Jiang, K. C. Allen Chan, Suk H. Cheng, Haiqiang Zhang, Wenlei Peng, O. Y. Olivia Tse, Yu K. Tong, Wanxia Gai, Benny C. Y. Zee, Brigette B. Y. Ma, Edwin P. Hui, Anthony T. C. Chan, John K. S. Woo, Rossa W. K. Chiu, and Y. M. Dennis Lo
  
  PNAS May 29, 2018 115 (22) E5115-E5124; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1804184115
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  MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells
  Sarmistha Talukdar, Anjan K. Pradhan, Praveen Bhoopathi, Xue-Ning Shen, Laura A. August, Jolene J. Windle, Devanand Sarkar, Frank B. Furnari, Webster K. Cavenee, Swadesh K. Das, Luni Emdad, and Paul B. Fisher
  
  PNAS May 29, 2018 115 (22) 5768-5773; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1721650115
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  Spatial mutation patterns as markers of early colorectal tumor cell mobility
  Marc D. Ryser, Byung-Hoon Min, Kimberly D. Siegmund, and Darryl Shibata
  
  PNAS May 29, 2018 115 (22) 5774-5779; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1716552115
- Open Access
  Volatile biomarkers of symptomatic and asymptomatic malaria infection in humans
  Consuelo M. De Moraes, Caroline Wanjiku, Nina M. Stanczyk, Hannier Pulido, James W. Sims, Heike S. Betz, Andrew F. Read, Baldwyn Torto, and Mark C. Mescher
  
  PNAS May 29, 2018 115 (22) 5780-5785; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1801512115
Microbiology
- Open Access
  Pseudomonas aeruginosa transcriptome during human infection
  Daniel M. Cornforth, Justine L. Dees, Carolyn B. Ibberson, Holly K. Huse, Inger H. Mathiesen, Klaus Kirketerp-Møller, Randy D. Wolcott, Kendra P. Rumbaugh, Thomas Bjarnsholt, and Marvin Whiteley
  
  PNAS May 29, 2018 115 (22) E5125-E5134; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1717525115
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  Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility
  Wentao Li, Ruben J. G. Hulswit, Scott P. Kenney, Ivy Widjaja, Kwonil Jung, Moyasar A. Alhamo, Brenda van Dieren, Frank J. M. van Kuppeveld, Linda J. Saif, and Berend-Jan Bosch
  
  PNAS May 29, 2018 115 (22) E5135-E5143; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1802879115
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  Long-distance electron transport in individual, living cable bacteria
  From the Cover
  
  Jesper T. Bjerg, Henricus T. S. Boschker, Steffen Larsen, David Berry, Markus Schmid, Diego Millo, Paula Tataru, Filip J. R. Meysman, Michael Wagner, Lars Peter Nielsen, and Andreas Schramm
  
  PNAS May 29, 2018 115 (22) 5786-5791; published ahead of print May 7, 2018. https://doi.org/10.1073/pnas.1800367115
Neuroscience
- Open Access
  Socioeconomic status moderates age-related differences in the brain’s functional network organization and anatomy across the adult lifespan
  Micaela Y. Chan, Jinkyung Na, Phillip F. Agres, Neil K. Savalia, Denise C. Park, and Gagan S. Wig
  
  PNAS May 29, 2018 115 (22) E5144-E5153; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1714021115
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  Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
  Xiang-Zhen Kong, Samuel R. Mathias, Tulio Guadalupe, ENIGMA Laterality Working Group, David C. Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E. Fisher, Paul M. Thompson, and Clyde Francks
  
  PNAS May 29, 2018 115 (22) E5154-E5163; published ahead of print May 15, 2018. https://doi.org/10.1073/pnas.1718418115
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  Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson’s disease
  Kwang Soo Kim, Paul C. Marcogliese, Jungwoo Yang, Steve M. Callaghan, Virginia Resende, Elizabeth Abdel-Messih, Connie Marras, Naomi P. Visanji, Jana Huang, Michael G. Schlossmacher, Laura Trinkle-Mulcahy, Ruth S. Slack, Anthony E. Lang, Canadian Lrrk2 in Inflammation Team (CLINT), and David S. Park
  
  PNAS May 29, 2018 115 (22) E5164-E5173; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1718946115
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  Functional organization of intrinsic and feedback presynaptic inputs in the primary visual cortex
  Qing-fang Zhang, Hao Li, Ming Chen, Aike Guo, Yunqing Wen, and Mu-ming Poo
  
  PNAS May 29, 2018 115 (22) E5174-E5182; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1719711115
- Open Access
  Quantitative assessment of prefrontal cortex in humans relative to nonhuman primates
  Chad J. Donahue, Matthew F. Glasser, Todd M. Preuss, James K. Rilling, and David C. Van Essen
  
  PNAS May 29, 2018 115 (22) E5183-E5192; published ahead of print May 8, 2018. https://doi.org/10.1073/pnas.1721653115
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  A neural pathway controlling motivation to exert effort
  Christophe D. Proulx, Sage Aronson, Djordje Milivojevic, Cris Molina, Alan Loi, Bradley Monk, Steven J. Shabel, and Roberto Malinow
  
  PNAS May 29, 2018 115 (22) 5792-5797; published ahead of print May 11, 2018. https://doi.org/10.1073/pnas.1801837115
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  Estrogen receptor β controls proliferation of enteric glia and differentiation of neurons in the myenteric plexus after damage
  F. D’Errico, G. Goverse, Y. Dai, W. Wu, M. Stakenborg, E. Labeeuw, V. De Simone, B. Verstockt, P. J. Gomez-Pinilla, M. Warner, A. Di Leo, G. Matteoli, and J. A. Gustafsson
  
  PNAS May 29, 2018 115 (22) 5798-5803; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1720267115
Physiology
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  Mapping the functional anatomy of Orai1 transmembrane domains for CRAC channel gating
  Priscilla S.-W. Yeung, Megumi Yamashita, Christopher E. Ing, Régis Pomès, Douglas M. Freymann, and Murali Prakriya
  
  PNAS May 29, 2018 115 (22) E5193-E5202; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1718373115
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  Insulin suppresses the production of fibroblast growth factor 23 (FGF23)
  Ludmilla Bär, Martina Feger, Abul Fajol, Lars-Oliver Klotz, Shufei Zeng, Florian Lang, Berthold Hocher, and Michael Föller
  
  PNAS May 29, 2018 115 (22) 5804-5809; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800160115
Plant Biology
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  Salicylic acid-independent role of NPR1 is required for protection from proteotoxic stress in the plant endoplasmic reticulum
  Ya-Shiuan Lai, Luciana Renna, John Yarema, Cristina Ruberti, Sheng Yang He, and Federica Brandizzi
  
  PNAS May 29, 2018 115 (22) E5203-E5212; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1802254115
- Open Access
  MYB72-dependent coumarin exudation shapes root microbiome assembly to promote plant health
  From the Cover
  
  Ioannis A. Stringlis, Ke Yu, Kirstin Feussner, Ronnie de Jonge, Sietske Van Bentum, Marcel C. Van Verk, Roeland L. Berendsen, Peter A. H. M. Bakker, Ivo Feussner, and Corné M. J. Pieterse
  
  PNAS May 29, 2018 115 (22) E5213-E5222; published ahead of print April 23, 2018. https://doi.org/10.1073/pnas.1722335115
- Open Access
  Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis
  From the Cover
  
  Zhaonan Ban, Hao Qin, Andrew J. Mitchell, Baoxiu Liu, Fengxia Zhang, Jing-Ke Weng, Richard A. Dixon, and Guodong Wang
  
  PNAS May 29, 2018 115 (22) E5223-E5232; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1802223115
- You have access
  Calcium, conformational selection, and redox-active tyrosine YZ in the photosynthetic oxygen-evolving cluster
  Zhanjun Guo, Jiayuan He, and Bridgette A. Barry
  
  PNAS May 29, 2018 115 (22) 5658-5663; published ahead of print May 11, 2018. https://doi.org/10.1073/pnas.1800758115
- You have access
  AtPep3 is a hormone-like peptide that plays a role in the salinity stress tolerance of plants
  Kentaro Nakaminami, Masanori Okamoto, Mieko Higuchi-Takeuchi, Takeshi Yoshizumi, Yube Yamaguchi, Yoichiro Fukao, Minami Shimizu, Chihiro Ohashi, Maho Tanaka, Minami Matsui, Kazuo Shinozaki, Motoaki Seki, and Kousuke Hanada
  
  PNAS May 29, 2018 115 (22) 5810-5815; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1719491115
Psychological and Cognitive Sciences
- Open Access
  Corticoinsular circuits encode subjective value expectation and violation for effortful goal-directed behavior
  Amanda R. Arulpragasam, Jessica A. Cooper, Makiah R. Nuutinen, and Michael T. Treadway
  
  PNAS May 29, 2018 115 (22) E5233-E5242; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800444115
- Open Access
  Nouns slow down speech across structurally and culturally diverse languages
  Frank Seifart, Jan Strunk, Swintha Danielsen, Iren Hartmann, Brigitte Pakendorf, Søren Wichmann, Alena Witzlack-Makarevich, Nivja H. de Jong, and Balthasar Bickel
  
  PNAS May 29, 2018 115 (22) 5720-5725; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1800708115
Systems Biology
- Open Access
  Temperature regulates NF-κB dynamics and function through timing of A20 transcription
  C. V. Harper, D. J. Woodcock, C. Lam, M. Garcia-Albornoz, A. Adamson, L. Ashall, W. Rowe, P. Downton, L. Schmidt, S. West, D. G. Spiller, D. A. Rand, and M. R. H. White
  
  PNAS May 29, 2018 115 (22) E5243-E5249; published ahead of print May 14, 2018. https://doi.org/10.1073/pnas.1803609115

Corrections (Online Only)

You have access
Correction for Vaidyanathan, Core Concept: Microgrids offer flexible energy generation, for a price
PNAS May 29, 2018 115 (22) E5250; published ahead of print May 21, 2018. https://doi.org/10.1073/pnas.1807693115
You have access
Correction for DeMille et al., Worldwide distribution of the DCDC2 READ1 regulatory element and its relationship with phoneme variation across languages
PNAS May 29, 2018 115 (22) E5251; published ahead of print May 21, 2018. https://doi.org/10.1073/pnas.1807672115
You have access
Correction for Li et al., Gα_i1 and Gα_i3 regulate macrophage polarization by forming a complex containing CD14 and Gab1
PNAS May 29, 2018 115 (22) E5252; published ahead of print May 21, 2018. https://doi.org/10.1073/pnas.1807268115
You have access
Correction for Woo et al., Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum
PNAS May 29, 2018 115 (22) E5253; published ahead of print May 21, 2018. https://doi.org/10.1073/pnas.1807631115

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