Temperature regulates NF-κB dynamics and function through timing of A20 transcription

^aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
^bMathematics Institute, University of Warwick, CV4 7AL Coventry, United Kingdom;
^cZeeman Institute for Systems Biology and Infectious Epidemiology Research, University of Warwick, CV4 7AL Coventry, United Kingdom;
^dDivision of Evolution and Genomic Sciences, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
^eInstitute of Integrative Biology, University of Liverpool, L69 7ZB United Kingdom

Edited by Ronald N. Germain, National Institutes of Health, Bethesda, MD, and approved April 27, 2018 (received for review March 7, 2018)

Footnotes

↵¹C.V.H. and D.J.W. contributed equally to the work.
↵²To whom correspondence may be addressed. Email: david.rand{at}warwick.ac.uk or mike.white{at}manchester.ac.uk.

Author contributions: C.V.H., D.J.W., D.A.R., and M.R.H.W. designed research; C.V.H., D.J.W., C.L., L.A., P.D., L.S., S.W., and D.A.R. performed research; D.J.W. and A.A. contributed new reagents/analytic tools; C.V.H., D.J.W., M.G.-A., and W.R. analyzed data; C.V.H., D.J.W., D.G.S., D.A.R., and M.R.H.W. wrote the paper; D.G.S. managed microscopy facility and assisted with microscopy experiments; D.A.R. jointly directed project with a focus on modeling and bioinformatics; and M.R.H.W. initiated and jointly directed project with a focus on experimental work.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
Data deposition: Gene expression data reported in this paper have been deposited in the ArrayExpress database, https://www.ebi.ac.uk/arrayexpress (accession no. E-MTAB-5158).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1803609115/-/DCSupplemental.