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Research Article

Temperature regulates NF-κB dynamics and function through timing of A20 transcription

C. V. Harper, D. J. Woodcock, C. Lam, M. Garcia-Albornoz, View ORCID ProfileA. Adamson, L. Ashall, W. Rowe, P. Downton, L. Schmidt, S. West, D. G. Spiller, D. A. Rand, and View ORCID ProfileM. R. H. White
PNAS May 29, 2018 115 (22) E5243-E5249; first published May 14, 2018; https://doi.org/10.1073/pnas.1803609115
C. V. Harper
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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D. J. Woodcock
bMathematics Institute, University of Warwick, CV4 7AL Coventry, United Kingdom;
cZeeman Institute for Systems Biology and Infectious Epidemiology Research, University of Warwick, CV4 7AL Coventry, United Kingdom;
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C. Lam
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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M. Garcia-Albornoz
dDivision of Evolution and Genomic Sciences, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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A. Adamson
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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  • ORCID record for A. Adamson
L. Ashall
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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W. Rowe
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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P. Downton
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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L. Schmidt
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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S. West
eInstitute of Integrative Biology, University of Liverpool, L69 7ZB United Kingdom
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D. G. Spiller
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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D. A. Rand
bMathematics Institute, University of Warwick, CV4 7AL Coventry, United Kingdom;
cZeeman Institute for Systems Biology and Infectious Epidemiology Research, University of Warwick, CV4 7AL Coventry, United Kingdom;
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  • For correspondence: david.rand@warwick.ac.uk mike.white@manchester.ac.uk
M. R. H. White
aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
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  • ORCID record for M. R. H. White
  • For correspondence: david.rand@warwick.ac.uk mike.white@manchester.ac.uk
  1. Edited by Ronald N. Germain, National Institutes of Health, Bethesda, MD, and approved April 27, 2018 (received for review March 7, 2018)

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Article Information

vol. 115 no. 22 E5243-E5249
DOI: 
https://doi.org/10.1073/pnas.1803609115
PubMed: 
29760065

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue May 29, 2018.
  • Published first May 14, 2018.

Article Versions

  • Previous version (May 14, 2018 - 11:52).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. C. V. Harpera,1,
  2. D. J. Woodcockb,c,1,
  3. C. Lama,
  4. M. Garcia-Albornozd,
  5. A. Adamsona,
  6. L. Ashalla,
  7. W. Rowea,
  8. P. Downtona,
  9. L. Schmidta,
  10. S. Weste,
  11. D. G. Spillera,
  12. D. A. Randb,c,2, and
  13. M. R. H. Whitea,2
  1. aSystems Microscopy Centre, Division of Molecular and Cellular Function, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
  2. bMathematics Institute, University of Warwick, CV4 7AL Coventry, United Kingdom;
  3. cZeeman Institute for Systems Biology and Infectious Epidemiology Research, University of Warwick, CV4 7AL Coventry, United Kingdom;
  4. dDivision of Evolution and Genomic Sciences, School of Biology, Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom;
  5. eInstitute of Integrative Biology, University of Liverpool, L69 7ZB United Kingdom
  1. Edited by Ronald N. Germain, National Institutes of Health, Bethesda, MD, and approved April 27, 2018 (received for review March 7, 2018)

Footnotes

  • ↵1C.V.H. and D.J.W. contributed equally to the work.

  • ↵2To whom correspondence may be addressed. Email: david.rand{at}warwick.ac.uk or mike.white{at}manchester.ac.uk.
  • Author contributions: C.V.H., D.J.W., D.A.R., and M.R.H.W. designed research; C.V.H., D.J.W., C.L., L.A., P.D., L.S., S.W., and D.A.R. performed research; D.J.W. and A.A. contributed new reagents/analytic tools; C.V.H., D.J.W., M.G.-A., and W.R. analyzed data; C.V.H., D.J.W., D.G.S., D.A.R., and M.R.H.W. wrote the paper; D.G.S. managed microscopy facility and assisted with microscopy experiments; D.A.R. jointly directed project with a focus on modeling and bioinformatics; and M.R.H.W. initiated and jointly directed project with a focus on experimental work.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • Data deposition: Gene expression data reported in this paper have been deposited in the ArrayExpress database, https://www.ebi.ac.uk/arrayexpress (accession no. E-MTAB-5158).

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1803609115/-/DCSupplemental.

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Article usage

Article usage: May 2018 to January 2021

AbstractFullPdf
May 201835692391532
Jun 20181882678208
Jul 2018117240157
Aug 201846424237
Sep 201827725662
Oct 20184920874
Nov 20181416787
Dec 2018815744
Total 2018743545001101
Jan 20191322641
Feb 20191418421
Mar 20191816137
Apr 20191618551
May 20197115334
Jun 2019821024
Jul 2019213726
Aug 2019614735
Sep 2019413622
Oct 20191616137
Nov 20191336650
Dec 2019747533
Total 20191882541411
Jan 2020723367
Feb 2020936663
Mar 20205412071030
Apr 202016673590
May 20207272163
Jun 20203338270
Jul 20205150195
Aug 20201015149
Sep 2020618045
Oct 20201319657
Nov 20202029964
Dec 20201624965
Total 202016643142658
Jan 20219165139
Total 20219165139
Total7798115204309
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Temperature regulates NF-κB dynamics and function through timing of A20 transcription
C. V. Harper, D. J. Woodcock, C. Lam, M. Garcia-Albornoz, A. Adamson, L. Ashall, W. Rowe, P. Downton, L. Schmidt, S. West, D. G. Spiller, D. A. Rand, M. R. H. White
Proceedings of the National Academy of Sciences May 2018, 115 (22) E5243-E5249; DOI: 10.1073/pnas.1803609115

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Temperature regulates NF-κB dynamics and function through timing of A20 transcription
C. V. Harper, D. J. Woodcock, C. Lam, M. Garcia-Albornoz, A. Adamson, L. Ashall, W. Rowe, P. Downton, L. Schmidt, S. West, D. G. Spiller, D. A. Rand, M. R. H. White
Proceedings of the National Academy of Sciences May 2018, 115 (22) E5243-E5249; DOI: 10.1073/pnas.1803609115
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