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Distribution shapes govern the discovery of predictive models for gene regulation

Brian Munsky, Guoliang Li, Zachary R. Fox, Douglas P. Shepherd, and Gregor Neuert
PNAS July 17, 2018 115 (29) 7533-7538; published ahead of print June 29, 2018 https://doi.org/10.1073/pnas.1804060115
Brian Munsky
aDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO 80523;bKeck Scholars, School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523;
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  • ORCID record for Brian Munsky
  • For correspondence: munsky@colostate.edugregor.neuert@vanderbilt.edu
Guoliang Li
cDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232;
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Zachary R. Fox
bKeck Scholars, School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523;
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Douglas P. Shepherd
dDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;
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Gregor Neuert
cDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232;eDepartment of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, TN 37232;fDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN 37232
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  • For correspondence: munsky@colostate.edugregor.neuert@vanderbilt.edu
  1. Edited by Herbert Levine, Rice University, Houston, TX, and approved May 31, 2018 (received for review March 10, 2018)

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Article Information

vol. 115 no. 29 7533-7538
DOI: 
https://doi.org/10.1073/pnas.1804060115
PubMed: 
29959206

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue July 17, 2018.
  • Published first June 29, 2018.

Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Brian Munskya,b,1,
  2. Guoliang Lic,
  3. Zachary R. Foxb,
  4. Douglas P. Shepherdd, and
  5. Gregor Neuertc,e,f,1
  1. aDepartment of Chemical and Biological Engineering, Colorado State University, Fort Collins, CO 80523;
  2. bKeck Scholars, School of Biomedical Engineering, Colorado State University, Fort Collins, CO 80523;
  3. cDepartment of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, TN 37232;
  4. dDepartment of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;
  5. eDepartment of Biomedical Engineering, School of Engineering, Vanderbilt University, Nashville, TN 37232;
  6. fDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN 37232
  1. Edited by Herbert Levine, Rice University, Houston, TX, and approved May 31, 2018 (received for review March 10, 2018)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: munsky{at}colostate.edu or gregor.neuert{at}vanderbilt.edu.
  • Author contributions: B.M. and G.N. designed research; B.M., G.L., Z.R.F., D.P.S., and G.N. performed research; B.M., Z.R.F., and G.N. contributed new reagents/analytic tools; B.M. and G.N. analyzed data; and B.M. and G.N. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1804060115/-/DCSupplemental.

Cited By...

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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Experimental and engineering approaches to intracellular communication
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    Essays In Biochemistry 2018 62 4

Article usage

Article usage: June 2018 to February 2019

AbstractFullPdf
Jun 201841730152
Jul 201835461438515
Aug 201883632198
Sep 201822619372
Oct 20184614678
Nov 20185212859
Dec 2018277626
Total 201851502603900
Jan 20192519838
Feb 2019114023
Total 20193623861
Total51862841961
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Distribution shapes govern the discovery of predictive models for gene regulation
Brian Munsky, Guoliang Li, Zachary R. Fox, Douglas P. Shepherd, Gregor Neuert
Proceedings of the National Academy of Sciences Jul 2018, 115 (29) 7533-7538; DOI: 10.1073/pnas.1804060115

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Distribution shapes govern the discovery of predictive models for gene regulation
Brian Munsky, Guoliang Li, Zachary R. Fox, Douglas P. Shepherd, Gregor Neuert
Proceedings of the National Academy of Sciences Jul 2018, 115 (29) 7533-7538; DOI: 10.1073/pnas.1804060115
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