Proceedings of the National Academy of Sciences: 115 (34)

New Research In

August 21, 2018; vol. 115 no. 34

This Week in PNAS

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In This Issue
PNAS August 21, 2018 115 (34) 8461-8462; https://doi.org/10.1073/iti3418115

Letters (Online Only)

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Can the pH at the air/water interface be different from the pH of bulk water?
Agustín J. Colussi

PNAS August 21, 2018 115 (34) E7887; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1811632115
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Reply to Colussi: Microdroplet interfacial pH, the ongoing discussion
Peter J. Vikesland, Haoran Wei, Qishen Huang, Huiyuan Guo, and Linsey C. Marr

PNAS August 21, 2018 115 (34) E7888-E7889; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1811902115
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Psychological targeting
Byron Sharp, Nick Danenberg, and Steven Bellman

PNAS August 21, 2018 115 (34) E7890; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1810436115
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Reply to Sharp et al.: Psychological targeting produces robust effects
S. C. Matz, M. Kosinski, G. Nave, and D. J. Stillwell

PNAS August 21, 2018 115 (34) E7891; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1811106115
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Human ectoparasite transmission of the plague during the Second Pandemic is only weakly supported by proposed mathematical models
Sang Woo Park, Jonathan Dushoff, David J. D. Earn, Hendrik Poinar, and Benjamin M. Bolker

PNAS August 21, 2018 115 (34) E7892-E7893; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1809775115
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Reply to Park et al.: Human ectoparasite transmission of plague during the Second Pandemic is still plausible
Katharine R. Dean, Fabienne Krauer, Lars Walløe, Ole Christian Lingjærde, Barbara Bramanti, Nils C. Stenseth, and Boris V. Schmid

PNAS August 21, 2018 115 (34) E7894-E7895; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1810221115

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: After years of listening with detectors buried in Antarctic ice, IceCube researchers trace neutrino source
Front Matter
Nola Taylor Redd

PNAS August 21, 2018 115 (34) 8463-8465; published ahead of print July 18, 2018. https://doi.org/10.1073/pnas.1811817115

Profile

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Profile of Michael Tomasello
Jennifer Viegas

PNAS August 21, 2018 115 (34) 8466-8468; published ahead of print August 13, 2018. https://doi.org/10.1073/pnas.1812244115

Commentaries

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Aragonite formation in confinements: A step toward understanding polymorph control
Yifei Xu and Nico A. J. M. Sommerdijk

PNAS August 21, 2018 115 (34) 8469-8471; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1811696115
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Squeezing cells through the epigenetic machinery
Jae-Won Shin

PNAS August 21, 2018 115 (34) 8472-8474; published ahead of print August 9, 2018. https://doi.org/10.1073/pnas.1811184115
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Myriad of implications of acetyl-l-carnitine deficits in depression
Robert M. Post

PNAS August 21, 2018 115 (34) 8475-8477; published ahead of print August 1, 2018. https://doi.org/10.1073/pnas.1811389115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS August 21, 2018 115 (34) 8478-8481; https://doi.org/10.1073/pnas.ss11534

Perspective

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When did Homo sapiens first reach Southeast Asia and Sahul?
James F. O’Connell, Jim Allen, Martin A. J. Williams, Alan N. Williams, Chris S. M. Turney, Nigel A. Spooner, Johan Kamminga, Graham Brown, and Alan Cooper

PNAS August 21, 2018 115 (34) 8482-8490; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1808385115

Physical Sciences

Applied Mathematics
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  Origin of Jupiter’s cloud-level zonal winds remains a puzzle even after Juno
  Dali Kong, Keke Zhang, Gerald Schubert, and John D. Anderson
  
  PNAS August 21, 2018 115 (34) 8499-8504; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1805927115
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  Solving high-dimensional partial differential equations using deep learning
  Jiequn Han, Arnulf Jentzen, and Weinan E
  
  PNAS August 21, 2018 115 (34) 8505-8510; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1718942115
Applied Physical Sciences
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  Quantum control of phase fluctuations in semiconductor lasers
  Christos T. Santis, Yaakov Vilenchik, Naresh Satyan, George Rakuljic, and Amnon Yariv
  
  PNAS August 21, 2018 115 (34) E7896-E7904; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1806716115
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  Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling
  Jennifer-Magdalena Masch, Heinz Steffens, Joachim Fischer, Johann Engelhardt, Jasmine Hubrich, Jan Keller-Findeisen, Elisa D’Este, Nicolai T. Urban, Seth G. N. Grant, Steffen J. Sahl, Dirk Kamin, and Stefan W. Hell
  
  PNAS August 21, 2018 115 (34) E8047-E8056; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807104115
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  Electrically induced 2D half-metallic antiferromagnets and spin field effect transistors
  Shi-Jing Gong, Cheng Gong, Yu-Yun Sun, Wen-Yi Tong, Chun-Gang Duan, Jun-Hao Chu, and Xiang Zhang
  
  PNAS August 21, 2018 115 (34) 8511-8516; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1715465115
Biophysics and Computational Biology
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  Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill
  From the Cover
  
  Xingcheng Lin, Jeffrey K. Noel, Qinghua Wang, Jianpeng Ma, and José N. Onuchic
  
  PNAS August 21, 2018 115 (34) E7905-E7913; published ahead of print July 16, 2018. https://doi.org/10.1073/pnas.1805442115
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  In vitro single-cell dissection revealing the interior structure of cable bacteria
  Zaixing Jiang, Shuai Zhang, Lasse Hyldgaard Klausen, Jie Song, Qiang Li, Zegao Wang, Bjørn Torger Stokke, Yudong Huang, Flemming Besenbacher, Lars Peter Nielsen, and Mingdong Dong
  
  PNAS August 21, 2018 115 (34) 8517-8522; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807562115
Chemistry
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  Stabilized photoanodes for water oxidation by integration of organic dyes, water oxidation catalysts, and electron-transfer mediators
  Degao Wang, Michael S. Eberhart, Matthew V. Sheridan, Ke Hu, Benjamin D. Sherman, Animesh Nayak, Ying Wang, Seth L. Marquard, Christopher J. Dares, and Thomas J. Meyer
  
  PNAS August 21, 2018 115 (34) 8523-8528; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1802903115
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  Lithium metal stripping beneath the solid electrolyte interphase
  Feifei Shi, Allen Pei, David Thomas Boyle, Jin Xie, Xiaoyun Yu, Xiaokun Zhang, and Yi Cui
  
  PNAS August 21, 2018 115 (34) 8529-8534; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1806878115
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  Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds
  Rustem I. Litvinov, Olga Kononova, Artem Zhmurov, Kenneth A. Marx, Valeri Barsegov, D. Thirumalai, and John W. Weisel
  
  PNAS August 21, 2018 115 (34) 8575-8580; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1802576115
- Open Access
  Fatty-acid derivative acts as a sea lamprey migratory pheromone
  Ke Li, Cory O. Brant, Mar Huertas, Edward J. Hessler, Gellert Mezei, Anne M. Scott, Thomas R. Hoye, and Weiming Li
  
  PNAS August 21, 2018 115 (34) 8603-8608; published ahead of print July 30, 2018. https://doi.org/10.1073/pnas.1803169115
Earth, Atmospheric, and Planetary Sciences
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  Insights into the origin of carbonaceous chondrite organics from their triple oxygen isotope composition
  Romain Tartèse, Marc Chaussidon, Andrey Gurenko, Frédéric Delarue, and François Robert
  
  PNAS August 21, 2018 115 (34) 8535-8540; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1808101115
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  Five-S-isotope evidence of two distinct mass-independent sulfur isotope effects and implications for the modern and Archean atmospheres
  Mang Lin, Xiaolin Zhang, Menghan Li, Yilun Xu, Zhisheng Zhang, Jun Tao, Binbin Su, Lanzhong Liu, Yanan Shen, and Mark H. Thiemens
  
  PNAS August 21, 2018 115 (34) 8541-8546; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1803420115
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  Volatile element evolution of chondrules through time
  Brandon Mahan, Frédéric Moynier, Julien Siebert, Bleuenn Gueguen, Arnaud Agranier, Emily A. Pringle, Jean Bollard, James N. Connelly, and Martin Bizzarro
  
  PNAS August 21, 2018 115 (34) 8547-8552; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807263115
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  Natural and managed watersheds show similar responses to recent climate change
  Darren L. Ficklin, John T. Abatzoglou, Scott M. Robeson, Sarah E. Null, and Jason H. Knouft
  
  PNAS August 21, 2018 115 (34) 8553-8557; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1801026115
Physics
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  Evidence for a conducting surface ground state in high-quality single crystalline FeSi
  Yuankan Fang, Sheng Ran, Weiwei Xie, Shen Wang, Ying Shirley Meng, and M. Brian Maple
  
  PNAS August 21, 2018 115 (34) 8558-8562; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1806910115
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  Breakdown of the Wiedemann–Franz law in a unitary Fermi gas
  Dominik Husmann, Martin Lebrat, Samuel Häusler, Jean-Philippe Brantut, Laura Corman, and Tilman Esslinger
  
  PNAS August 21, 2018 115 (34) 8563-8568; published ahead of print August 9, 2018. https://doi.org/10.1073/pnas.1803336115

Biological Sciences

Biochemistry
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  The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites
  Matthias Quick, Ara M. Abramyan, Pattama Wiriyasermkul, Harel Weinstein, Lei Shi, and Jonathan A. Javitch
  
  PNAS August 21, 2018 115 (34) E7924-E7931; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1717444115
Biophysics and Computational Biology
- You have access
  Atomistic simulations indicate the functional loop-to-coiled-coil transition in influenza hemagglutinin is not downhill
  From the Cover
  
  Xingcheng Lin, Jeffrey K. Noel, Qinghua Wang, Jianpeng Ma, and José N. Onuchic
  
  PNAS August 21, 2018 115 (34) E7905-E7913; published ahead of print July 16, 2018. https://doi.org/10.1073/pnas.1805442115
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  Structure of the EmrE multidrug transporter and its use for inhibitor peptide design
  Victor Ovchinnikov, Tracy A. Stone, Charles M. Deber, and Martin Karplus
  
  PNAS August 21, 2018 115 (34) E7932-E7941; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1802177115
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  C-terminal kink formation is required for lateral gating in BamA
  Karl Lundquist, Jeremy Bakelar, Nicholas Noinaj, and James C. Gumbart
  
  PNAS August 21, 2018 115 (34) E7942-E7949; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1722530115
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  Directionally biased sidestepping of Kip3/kinesin-8 is regulated by ATP waiting time and motor–microtubule interaction strength
  Aniruddha Mitra, Felix Ruhnow, Salvatore Girardo, and Stefan Diez
  
  PNAS August 21, 2018 115 (34) E7950-E7959; published ahead of print August 9, 2018. https://doi.org/10.1073/pnas.1801820115
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  Regulatory element in fibrin triggers tension-activated transition from catch to slip bonds
  Rustem I. Litvinov, Olga Kononova, Artem Zhmurov, Kenneth A. Marx, Valeri Barsegov, D. Thirumalai, and John W. Weisel
  
  PNAS August 21, 2018 115 (34) 8575-8580; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1802576115
Cell Biology
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  MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca²⁺ and Mn²⁺
  Kimberli J. Kamer, Yasemin Sancak, Yevgenia Fomina, Joshua D. Meisel, Dipayan Chaudhuri, Zenon Grabarek, and Vamsi K. Mootha
  
  PNAS August 21, 2018 115 (34) E7960-E7969; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807811115
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  Lariat intronic RNAs in the cytoplasm of vertebrate cells
  Gaëlle J. S. Talhouarne and Joseph G. Gall
  
  PNAS August 21, 2018 115 (34) E7970-E7977; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1808816115
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  WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment
  From the Cover
  
  Pengbo Wang, Marcel Dreger, Elena Madrazo, Craig J. Williams, Rafael Samaniego, Nigel W. Hodson, Francisco Monroy, Esther Baena, Paloma Sánchez-Mateos, Adam Hurlstone, and Javier Redondo-Muñoz
  
  PNAS August 21, 2018 115 (34) 8581-8586; published ahead of print July 9, 2018. https://doi.org/10.1073/pnas.1719405115
Developmental Biology
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  Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes
  Boryana Petrova, Keke Liu, Caiping Tian, Maiko Kitaoka, Elizaveta Freinkman, Jing Yang, and Terry L. Orr-Weaver
  
  PNAS August 21, 2018 115 (34) E7978-E7986; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807918115
Ecology
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  Declines in methane uptake in forest soils
  Xiangyin Ni and Peter M. Groffman
  
  PNAS August 21, 2018 115 (34) 8587-8590; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807377115
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  Isolating the roles of movement and reproduction on effective connectivity alters conservation priorities for an endangered bird
  Ellen P. Robertson, Robert J. Fletcher Jr., Christopher E. Cattau, Bradley J. Udell, Brian E. Reichert, James D. Austin, and Denis Valle
  
  PNAS August 21, 2018 115 (34) 8591-8596; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1800183115
- Open Access
  Collapse of a desert bird community over the past century driven by climate change
  Kelly J. Iknayan and Steven R. Beissinger
  
  PNAS August 21, 2018 115 (34) 8597-8602; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1805123115
Environmental Sciences
- Open Access
  Fatty-acid derivative acts as a sea lamprey migratory pheromone
  Ke Li, Cory O. Brant, Mar Huertas, Edward J. Hessler, Gellert Mezei, Anne M. Scott, Thomas R. Hoye, and Weiming Li
  
  PNAS August 21, 2018 115 (34) 8603-8608; published ahead of print July 30, 2018. https://doi.org/10.1073/pnas.1803169115
Evolution
- Open Access
  Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion
  From the Cover
  
  Ulrike Löber, Matthew Hobbs, Anisha Dayaram, Kyriakos Tsangaras, Kiersten Jones, David E. Alquezar-Planas, Yasuko Ishida, Joanne Meers, Jens Mayer, Claudia Quedenau, Wei Chen, Rebecca N. Johnson, Peter Timms, Paul R. Young, Alfred L. Roca, and Alex D. Greenwood
  
  PNAS August 21, 2018 115 (34) 8609-8614; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807598115
Genetics
- Open Access
  Casz1 controls higher-order nuclear organization in rod photoreceptors
  Pierre Mattar, Milanka Stevanovic, Ivana Nad, and Michel Cayouette
  
  PNAS August 21, 2018 115 (34) E7987-E7996; published ahead of print August 2, 2018. https://doi.org/10.1073/pnas.1803069115
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  Preferences in a trait decision determined by transcription factor variants
  Michael W. Dorrity, Josh T. Cuperus, Jolie A. Carlisle, Stanley Fields, and Christine Queitsch
  
  PNAS August 21, 2018 115 (34) E7997-E8006; published ahead of print August 1, 2018. https://doi.org/10.1073/pnas.1805882115
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  Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons
  Alexandre Bolze, Bertrand Boisson, Barbara Bosch, Alexander Antipenko, Matthieu Bouaziz, Paul Sackstein, Malik Chaker-Margot, Vincent Barlogis, Tracy Briggs, Elena Colino, Aurora C. Elmore, Alain Fischer, Ferah Genel, Angela Hewlett, Maher Jedidi, Jadranka Kelecic, Renate Krüger, Cheng-Lung Ku, Dinakantha Kumararatne, Alain Lefevre-Utile, Sam Loughlin, Nizar Mahlaoui, Susanne Markus, Juan-Miguel Garcia, Mathilde Nizon, Matias Oleastro, Malgorzata Pac, Capucine Picard, Andrew J. Pollard, Carlos Rodriguez-Gallego, Caroline Thomas, Horst Von Bernuth, Austen Worth, Isabelle Meyts, Maurizio Risolino, Licia Selleri, Anne Puel, Sebastian Klinge, Laurent Abel, and Jean-Laurent Casanova
  
  PNAS August 21, 2018 115 (34) E8007-E8016; published ahead of print August 2, 2018. https://doi.org/10.1073/pnas.1805437115
Immunology and Inflammation
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  Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity
  Marie Liebmann, Stephanie Hucke, Kathrin Koch, Melanie Eschborn, Julia Ghelman, Achmet I. Chasan, Shirin Glander, Martin Schädlich, Meike Kuhlencord, Niklas M. Daber, Maria Eveslage, Marc Beyer, Michael Dietrich, Philipp Albrecht, Monika Stoll, Karin B. Busch, Heinz Wiendl, Johannes Roth, Tanja Kuhlmann, and Luisa Klotz
  
  PNAS August 21, 2018 115 (34) E8017-E8026; published ahead of print August 2, 2018. https://doi.org/10.1073/pnas.1721049115
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  DUSP6 mediates T cell receptor-engaged glycolysis and restrains T_FH cell differentiation
  Wei-Chan Hsu, Ming-Yu Chen, Shu-Ching Hsu, Li-Rung Huang, Cheng-Yuan Kao, Wen-Hui Cheng, Chien-Hsiung Pan, Ming-Sian Wu, Guann-Yi Yu, Ming-Shiu Hung, Chuen-Miin Leu, Tse-Hua Tan, and Yu-Wen Su
  
  PNAS August 21, 2018 115 (34) E8027-E8036; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1800076115
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  Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination
  Jennifer L. Crowe, Zhengping Shao, Xiaobin S. Wang, Pei-Chi Wei, Wenxia Jiang, Brian J. Lee, Verna M. Estes, Frederick W. Alt, and Shan Zha
  
  PNAS August 21, 2018 115 (34) 8615-8620; published ahead of print August 2, 2018. https://doi.org/10.1073/pnas.1808490115
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  Extracellular matrix protein 1 promotes follicular helper T cell differentiation and antibody production
  Lan He, Wangpeng Gu, Meng Wang, Xiaoyan Chang, Xiaoyu Sun, Yuan Zhang, Xuan Lin, Chenghua Yan, Weiguo Fan, Pan Su, Yanming Wang, Chunyan Yi, Guomei Lin, Li Li, Yu Jiang, Junxia Lu, Chen Dong, Haikun Wang, and Bing Sun
  
  PNAS August 21, 2018 115 (34) 8621-8626; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1801196115
Medical Sciences
- Open Access
  Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies
  Charlotte Gistelinck, Ronald Y. Kwon, Fransiska Malfait, Sofie Symoens, Matthew P. Harris, Katrin Henke, Michael B. Hawkins, Shannon Fisher, Patrick Sips, Brecht Guillemyn, Jan Willem Bek, Petra Vermassen, Hanna De Saffel, Paul Eckhard Witten, MaryAnn Weis, Anne De Paepe, David R. Eyre, Andy Willaert, and Paul J. Coucke
  
  PNAS August 21, 2018 115 (34) E8037-E8046; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1722200115
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  Acetyl-l-carnitine deficiency in patients with major depressive disorder
  From the Cover
  
  Carla Nasca, Benedetta Bigio, Francis S. Lee, Sarah P. Young, Marin M. Kautz, Ashly Albright, James Beasley, David S. Millington, Aleksander A. Mathé, James H. Kocsis, James W. Murrough, Bruce S. McEwen, and Natalie Rasgon
  
  PNAS August 21, 2018 115 (34) 8627-8632; published ahead of print July 30, 2018. https://doi.org/10.1073/pnas.1801609115
Microbiology
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  In vitro single-cell dissection revealing the interior structure of cable bacteria
  Zaixing Jiang, Shuai Zhang, Lasse Hyldgaard Klausen, Jie Song, Qiang Li, Zegao Wang, Bjørn Torger Stokke, Yudong Huang, Flemming Besenbacher, Lars Peter Nielsen, and Mingdong Dong
  
  PNAS August 21, 2018 115 (34) 8517-8522; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807562115
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  Cargo transport shapes the spatial organization of a microbial community
  Abhishek Shrivastava, Visha K. Patel, Yisha Tang, Susan Connolly Yost, Floyd E. Dewhirst, and Howard C. Berg
  
  PNAS August 21, 2018 115 (34) 8633-8638; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1808966115
Neuroscience
- Open Access
  Robust nanoscopy of a synaptic protein in living mice by organic-fluorophore labeling
  Jennifer-Magdalena Masch, Heinz Steffens, Joachim Fischer, Johann Engelhardt, Jasmine Hubrich, Jan Keller-Findeisen, Elisa D’Este, Nicolai T. Urban, Seth G. N. Grant, Steffen J. Sahl, Dirk Kamin, and Stefan W. Hell
  
  PNAS August 21, 2018 115 (34) E8047-E8056; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807104115
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  Macrophage angiotensin II type 2 receptor triggers neuropathic pain
  Andrew J. Shepherd, Aaron D. Mickle, Judith P. Golden, Madison R. Mack, Carmen M. Halabi, Annette D. de Kloet, Vijay K. Samineni, Brian S. Kim, Eric G. Krause, Robert W. Gereau IV, and Durga P. Mohapatra
  
  PNAS August 21, 2018 115 (34) E8057-E8066; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1721815115
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  Differential inhibition of pyramidal cells and inhibitory interneurons along the rostrocaudal axis of anterior piriform cortex
  Adam M. Large, Nathan W. Vogler, Martha Canto-Bustos, F. Kathryn Friason, Paul Schick, and Anne-Marie M. Oswald
  
  PNAS August 21, 2018 115 (34) E8067-E8076; published ahead of print August 7, 2018. https://doi.org/10.1073/pnas.1802428115
- Open Access
  Selective Na_V1.1 activation rescues Dravet syndrome mice from seizures and premature death
  Kay L. Richards, Carol J. Milligan, Robert J. Richardson, Nikola Jancovski, Morten Grunnet, Laura H. Jacobson, Eivind A. B. Undheim, Mehdi Mobli, Chun Yuen Chow, Volker Herzig, Agota Csoti, Gyorgy Panyi, Christopher A. Reid, Glenn F. King, and Steven Petrou
  
  PNAS August 21, 2018 115 (34) E8077-E8085; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1804764115
Physiology
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  Insights into the molecular mechanism for hyperpolarization-dependent activation of HCN channels
  Galen E. Flynn and William N. Zagotta
  
  PNAS August 21, 2018 115 (34) E8086-E8095; published ahead of print August 3, 2018. https://doi.org/10.1073/pnas.1805596115
Plant Biology
- Open Access
  Third DWF1 paralog in Solanaceae, sterol Δ²⁴-isomerase, branches withanolide biosynthesis from the general phytosterol pathway
  Eva Knoch, Satoko Sugawara, Tetsuya Mori, Christian Poulsen, Atsushi Fukushima, Jesper Harholt, Yoshinori Fujimoto, Naoyuki Umemoto, and Kazuki Saito
  
  PNAS August 21, 2018 115 (34) E8096-E8103; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1807482115
Systems Biology
- Open Access
  Codon usage influences fitness through RNA toxicity
  Pragya Mittal, James Brindle, Julie Stephen, Joshua B. Plotkin, and Grzegorz Kudla
  
  PNAS August 21, 2018 115 (34) 8639-8644; published ahead of print August 6, 2018. https://doi.org/10.1073/pnas.1810022115

Correction (Online Only)

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Correction for Wang et al., Molecular origin of the weak susceptibility of kinesin velocity to loads and its relation to the collective behavior of kinesins
PNAS August 21, 2018 115 (34) E8104; published ahead of print August 13, 2018. https://doi.org/10.1073/pnas.1812987115

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