Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Accessibility Statement
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Special Feature Articles - Most Recent
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • List of Issues
  • Front Matter
  • News
    • For the Press
    • This Week In PNAS
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Editorial and Journal Policies
    • Submission Procedures
    • Fees and Licenses

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology
Research Article

Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders

Aaron X. Sun, Ricardo Londono, Megan L. Hudnall, Rocky S. Tuan, and Thomas P. Lozito
PNAS August 28, 2018 115 (35) E8256-E8265; first published August 13, 2018; https://doi.org/10.1073/pnas.1803780115
Aaron X. Sun
aCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
bMedical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
cDepartment of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA 15213
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ricardo Londono
aCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Megan L. Hudnall
aCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rocky S. Tuan
aCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
cDepartment of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA 15213
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas P. Lozito
aCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: tpl9@pitt.edu
  1. Edited by Robb Krumlauf, Stowers Institute for Medical Research, Kansas City, MO, and approved July 24, 2018 (received for review March 2, 2018)

  • Article
  • Figures & SI
  • Info & Metrics
  • PDF
Loading

Online Impact

 

Article Information

vol. 115 no. 35 E8256-E8265
DOI: 
https://doi.org/10.1073/pnas.1803780115
PubMed: 
30104374

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue August 28, 2018.
  • Published first August 13, 2018.

Article Versions

  • Previous version (August 13, 2018 - 11:47).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2018 Published under the PNAS license.

Author Information

  1. Aaron X. Suna,b,c,
  2. Ricardo Londonoa,
  3. Megan L. Hudnalla,
  4. Rocky S. Tuana,c, and
  5. Thomas P. Lozitoa,1
  1. aCenter for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219;
  2. bMedical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213;
  3. cDepartment of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA 15213
  1. Edited by Robb Krumlauf, Stowers Institute for Medical Research, Kansas City, MO, and approved July 24, 2018 (received for review March 2, 2018)

Footnotes

  • ↵1To whom correspondence should be addressed. Email: tpl9{at}pitt.edu.
  • Author contributions: A.X.S., R.S.T., and T.P.L. designed research; A.X.S., R.L., M.L.H., and T.P.L. performed research; A.X.S., R.L., M.L.H., and T.P.L. analyzed data; and A.X.S. and T.P.L. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1803780115/-/DCSupplemental.

Cited By...

  • 10 Citations
  • 10 Citations
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The untapped potential of reptile biodiversity for understanding how and why animals age
    Luke A. Hoekstra, Tonia S. Schwartz, Amanda M. Sparkman, David A. W. Miller, Anne M. Bronikowski, Jean‐François Lemaître
    Functional Ecology 2020 34 1
  • Transcriptional analysis of scar-free wound healing during early stages of tail regeneration in the green anole lizard, Anolis carolinensis
    Cindy Xu, Elizabeth D. Hutchins, Minami A. Tokuyama, Jeanne Wilson-Rawls, Kenro Kusumi
    Journal of Immunology and Regenerative Medicine 2020 7
  • Evolution of vertebrate spinal cord patterning
    Brigid Leung, Sebastian M. Shimeld
    Developmental Dynamics 2019 248 11
  • Investigating Nrg1 Signaling in the Regenerating Axolotl Spinal Cord Using Multiplexed FISH
    Polina D. Freitas, Alexander M. Lovely, James R. Monaghan
    Developmental Neurobiology 2019 79 5
  • The vertebrate tail: a gene playground for evolution
    Moisés Mallo
    Cellular and Molecular Life Sciences 2020 77 6
  • Convergence of human cellular models and genetics to study neural stem cell signaling to enhance central nervous system regeneration and repair
    Dominic Julian, Ethan W. Hollingsworth, Katherine Julian, Jaime Imitola
    Seminars in Cell & Developmental Biology 2019 95
  • Salamander-like tail regeneration in the West African lungfish
    Kellen Matos Verissimo, Louise Neiva Perez, Aline Cutrim Dragalzew, Gayani Senevirathne, Sylvain Darnet, Wainna Renata Barroso Mendes, Ciro Ariel dos Santos Neves, Erika Monteiro dos Santos, Cassia Nazare de Sousa Moraes, Ahmed Elewa, Neil Shubin, Nadia Belinda Fröbisch, Josane de Freitas Sousa, Igor Schneider
    Proceedings of the Royal Society B: Biological Sciences 2020 287 1935
  • High regenerative capacity is a general feature within colonial dendrophylliid corals (Anthozoa, Scleractinia)
    Bruna Louise Pereira Luz, David John Miller, Marcelo Visentini Kitahara
    Journal of Experimental Zoology Part B: Molecular and Developmental Evolution 2021
  • Immunolocalization of Wnts in the lizard blastema supports a key role of these signaling proteins for tail regeneration
    Lorenzo Alibardi
    Journal of Morphology 2020 281 1
  • Paraquat increases Interleukin-1β in hippocampal dentate gyrus to impair hippocampal neurogenesis in adult mice
    Qian Li, Hongxi Xiao, Yiming Shao, Xiuli Chang, Yubin Zhang, Zhijun Zhou
    Ecotoxicology and Environmental Safety 2020 200

Article usage

Article usage: August 2018 to February 2021

AbstractFullPdf
Aug 20184421464271
Sep 2018146013282
Oct 20182558952
Nov 201818911450
Dec 20181285239
Total 20186453851494
Jan 20191054414
Feb 20191273825
Mar 20191412435
Apr 20191212249
May 20193610526
Jun 2019510931
Jul 201939233
Aug 2019413437
Sep 2019314531
Oct 2019115230
Nov 2019210832
Dec 2019810823
Total 20193201281366
Jan 2020410619
Feb 202029225
Mar 2020311831
Apr 2020513621
May 2020418052
Jun 2020418319
Jul 2020110325
Aug 202028915
Sep 2020317831
Oct 20201019061
Nov 20201015638
Dec 20201711731
Total 2020651648368
Jan 202199029
Feb 202189931
Total 20211718960
Total685539691288
PreviousNext
Back to top
Article Alerts
Email Article

Thank you for your interest in spreading the word on PNAS.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders
(Your Name) has sent you a message from PNAS
(Your Name) thought you would like to see the PNAS web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders
Aaron X. Sun, Ricardo Londono, Megan L. Hudnall, Rocky S. Tuan, Thomas P. Lozito
Proceedings of the National Academy of Sciences Aug 2018, 115 (35) E8256-E8265; DOI: 10.1073/pnas.1803780115

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders
Aaron X. Sun, Ricardo Londono, Megan L. Hudnall, Rocky S. Tuan, Thomas P. Lozito
Proceedings of the National Academy of Sciences Aug 2018, 115 (35) E8256-E8265; DOI: 10.1073/pnas.1803780115
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Mendeley logo Mendeley
Proceedings of the National Academy of Sciences: 115 (35)
Table of Contents

Submit

Sign up for Article Alerts

Article Classifications

  • Biological Sciences
  • Developmental Biology

Jump to section

  • Article
    • Abstract
    • Results
    • Discussion
    • Materials and Methods
    • Acknowledgments
    • Footnotes
    • References
  • Figures & SI
  • Info & Metrics
  • PDF

You May Also be Interested in

Surgeons hands during surgery
Inner Workings: Advances in infectious disease treatment promise to expand the pool of donor organs
Despite myriad challenges, clinicians see room for progress.
Image credit: Shutterstock/David Tadevosian.
Setting sun over a sun-baked dirt landscape
Core Concept: Popular integrated assessment climate policy models have key caveats
Better explicating the strengths and shortcomings of these models will help refine projections and improve transparency in the years ahead.
Image credit: Witsawat.S.
Double helix
Journal Club: Noncoding DNA shown to underlie function, cause limb malformations
Using CRISPR, researchers showed that a region some used to label “junk DNA” has a major role in a rare genetic disorder.
Image credit: Nathan Devery.
Steamboat Geyser eruption.
Eruption of Steamboat Geyser
Mara Reed and Michael Manga explore why Yellowstone's Steamboat Geyser resumed erupting in 2018.
Listen
Past PodcastsSubscribe
Multi-color molecular model
Enzymatic breakdown of PET plastic
A study demonstrates how two enzymes—MHETase and PETase—work synergistically to depolymerize the plastic pollutant PET.
Image credit: Aaron McGeehan (artist).

Similar Articles

Site Logo
Powered by HighWire
  • Submit Manuscript
  • Twitter
  • Facebook
  • RSS Feeds
  • Email Alerts

Articles

  • Current Issue
  • Special Feature Articles – Most Recent
  • List of Issues

PNAS Portals

  • Anthropology
  • Chemistry
  • Classics
  • Front Matter
  • Physics
  • Sustainability Science
  • Teaching Resources

Information

  • Authors
  • Editorial Board
  • Reviewers
  • Librarians
  • Press
  • Site Map
  • PNAS Updates

Feedback    Privacy/Legal

Copyright © 2021 National Academy of Sciences. Online ISSN 1091-6490