Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Simultaneous improvements of strength and toughness in topologically interlocked ceramics

    Mohammad Mirkhalaf, Tao Zhou, and Francois Barthelat

    PNAS September 11, 2018 115 (37) 9128-9133; first published August 23, 2018. https://doi.org/10.1073/pnas.1807272115

• Biochemistry

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    Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations

    • From the Cover

    Nathaniel R. Glasser, Paul H. Oyala, Thomas H. Osborne, Joanne M. Santini, and Dianne K. Newman

    PNAS September 11, 2018 115 (37) E8614-E8623; first published August 13, 2018. https://doi.org/10.1073/pnas.1807984115

    See companion article:

    • Unraveling the inner workings of respiratory arsenate reductase

      - Sep 11, 2018
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    β-Subunit of the voltage-gated Ca²⁺ channel Cav1.2 drives signaling to the nucleus via H-Ras

    Evrim Servili, Michael Trus, Daphne Maayan, and Daphne Atlas

    PNAS September 11, 2018 115 (37) E8624-E8633; first published August 27, 2018. https://doi.org/10.1073/pnas.1805380115
  • Open Access

    De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug

    Jason Lancaster, Ashot Khrimian, Sharon Young, Bryan Lehner, Katrin Luck, Anna Wallingford, Saikat Kumar B. Ghosh, Philipp Zerbe, Andrew Muchlinski, Paul E. Marek, Michael E. Sparks, James G. Tokuhisa, Claus Tittiger, Tobias G. Köllner, Donald C. Weber, Dawn E. Gundersen-Rindal, Thomas P. Kuhar, and Dorothea Tholl

    PNAS September 11, 2018 115 (37) E8634-E8641; first published August 23, 2018. https://doi.org/10.1073/pnas.1800008115
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    Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins

    Jaime Andrés Rivas-Pardo, Carmen L. Badilla, Rafael Tapia-Rojo, Álvaro Alonso-Caballero, and Julio M. Fernández

    PNAS September 11, 2018 115 (37) 9222-9227; first published August 27, 2018. https://doi.org/10.1073/pnas.1807689115
  • Open Access

    Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks

    James J. Galligan, James A. Wepy, Matthew D. Streeter, Philip J. Kingsley, Michelle M. Mitchener, Orrette R. Wauchope, William N. Beavers, Kristie L. Rose, Tina Wang, David A. Spiegel, and Lawrence J. Marnett

    PNAS September 11, 2018 115 (37) 9228-9233; first published August 27, 2018. https://doi.org/10.1073/pnas.1802901115

• Biophysics and Computational Biology

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    Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding

    Jesper J. Madsen, John M. A. Grime, Jeremy S. Rossman, and Gregory A. Voth

    PNAS September 11, 2018 115 (37) E8595-E8603; first published August 27, 2018. https://doi.org/10.1073/pnas.1805443115
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    Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments

    Sofia Espinoza-Sanchez, Lauren Ann Metskas, Steven Z. Chou, Elizabeth Rhoades, and Thomas D. Pollard

    PNAS September 11, 2018 115 (37) E8642-E8651; first published August 27, 2018. https://doi.org/10.1073/pnas.1717594115
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    QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities

    Shuguang Zhang, Fei Tao, Rui Qing, Hongzhi Tang, Michael Skuhersky, Karolina Corin, Lotta Tegler, Asmamaw Wassie, Brook Wassie, Yongwon Kwon, Bernhard Suter, Clemens Entzian, Thomas Schubert, Ge Yang, Jörg Labahn, Jan Kubicek, and Barbara Maertens

    PNAS September 11, 2018 115 (37) E8652-E8659; first published August 28, 2018. https://doi.org/10.1073/pnas.1811031115
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    Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability

    Frank R. Moss III, Steven R. Shuken, Jaron A. M. Mercer, Carolyn M. Cohen, Thomas M. Weiss, Steven G. Boxer, and Noah Z. Burns

    PNAS September 11, 2018 115 (37) 9098-9103; first published August 27, 2018. https://doi.org/10.1073/pnas.1810706115
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    Size and topology modulate the effects of frustration in protein folding

    Alex Kluber, Timothy A. Burt, and Cecilia Clementi

    PNAS September 11, 2018 115 (37) 9234-9239; first published August 27, 2018. https://doi.org/10.1073/pnas.1801406115
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    Gating charge displacement in a monomeric voltage-gated proton (H_v1) channel

    • From the Cover

    Emerson M. Carmona, H. Peter Larsson, Alan Neely, Osvaldo Alvarez, Ramon Latorre, and Carlos Gonzalez

    PNAS September 11, 2018 115 (37) 9240-9245; first published August 20, 2018. https://doi.org/10.1073/pnas.1809705115

    See companion article:

    • Gating currents indicate complex gating of voltage-gated proton channels

      - Sep 11, 2018
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    Architecture of cell–cell adhesion mediated by sidekicks

    Hua Tang, Haishuang Chang, Yue Dong, Luqiang Guo, Xiangyi Shi, Yichun Wu, Ying Huang, and Yongning He

    PNAS September 11, 2018 115 (37) 9246-9251; first published August 27, 2018. https://doi.org/10.1073/pnas.1801810115

• Cell Biology

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    Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells

    Abu Shufian Ishtiaq Ahmed, Kunzhe Dong, Jinhua Liu, Tong Wen, Luyi Yu, Fei Xu, Xiuhua Kang, Islam Osman, Guoqing Hu, Kristopher M. Bunting, Danielle Crethers, Hongyu Gao, Wei Zhang, Yunlong Liu, Ke Wen, Gautam Agarwal, Tetsuro Hirose, Shinichi Nakagawa, Almira Vazdarjanova, and Jiliang Zhou

    PNAS September 11, 2018 115 (37) E8660-E8667; first published August 23, 2018. https://doi.org/10.1073/pnas.1803725115
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    BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export

    Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eiríkur Steingrímsson, Katherine L. B. Borden, E. Elizabeth Patton, and Colin R. Goding

    PNAS September 11, 2018 115 (37) E8668-E8677; first published August 27, 2018. https://doi.org/10.1073/pnas.1810498115

• Developmental Biology

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    Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132

    Jamie L. Lahvic, Michelle Ammerman, Pulin Li, Megan C. Blair, Emma R. Stillman, Eva M. Fast, Anne L. Robertson, Constantina Christodoulou, Julie R. Perlin, Song Yang, Nan Chiang, Paul C. Norris, Madeleine L. Daily, Shelby E. Redfield, Iris T. Chan, Mona Chatrizeh, Michael E. Chase, Olivia Weis, Yi Zhou, Charles N. Serhan, and Leonard I. Zon

    PNAS September 11, 2018 115 (37) 9252-9257; first published August 23, 2018. https://doi.org/10.1073/pnas.1806077115

• Ecology

  • Open Access

    Multiproxy evidence for leaf-browsing and closed habitats in extinct proboscideans (Mammalia, Proboscidea) from Central Chile

    Erwin González-Guarda, Alia Petermann-Pichincura, Carlos Tornero, Laura Domingo, Jordi Agustí, Mario Pino, Ana M. Abarzúa, José M. Capriles, Natalia A. Villavicencio, Rafael Labarca, Violeta Tolorza, Paloma Sevilla, and Florent Rivals

    PNAS September 11, 2018 115 (37) 9258-9263; first published August 27, 2018. https://doi.org/10.1073/pnas.1804642115
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    Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen’s feces

    Akiyuki Watarai, Natsuki Arai, Shingo Miyawaki, Hideyuki Okano, Kyoko Miura, Kazutaka Mogi, and Takefumi Kikusui

    PNAS September 11, 2018 115 (37) 9264-9269; first published August 27, 2018. https://doi.org/10.1073/pnas.1720530115
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    Remoteness promotes biological invasions on islands worldwide

    Dietmar Moser, Bernd Lenzner, Patrick Weigelt, Wayne Dawson, Holger Kreft, Jan Pergl, Petr Pyšek, Mark van Kleunen, Marten Winter, César Capinha, Phillip Cassey, Stefan Dullinger, Evan P. Economo, Pablo García-Díaz, Benoit Guénard, Florian Hofhansl, Thomas Mang, Hanno Seebens, and Franz Essl

    PNAS September 11, 2018 115 (37) 9270-9275; first published August 29, 2018. https://doi.org/10.1073/pnas.1804179115

• Environmental Sciences

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    Dynamic process connectivity explains ecohydrologic responses to rainfall pulses and drought

    Allison E. Goodwell, Praveen Kumar, Aaron W. Fellows, and Gerald N. Flerchinger

    PNAS September 11, 2018 115 (37) E8604-E8613; first published August 27, 2018. https://doi.org/10.1073/pnas.1800236115

• Evolution

  • Open Access

    Physical foundations of biological complexity

    Yuri I. Wolf, Mikhail I. Katsnelson, and Eugene V. Koonin

    PNAS September 11, 2018 115 (37) E8678-E8687; first published August 27, 2018. https://doi.org/10.1073/pnas.1807890115
  • Open Access

    Protein evolution speed depends on its stability and abundance and on chaperone concentrations

    Luca Agozzino and Ken A. Dill

    PNAS September 11, 2018 115 (37) 9092-9097; first published August 27, 2018. https://doi.org/10.1073/pnas.1810194115

• Genetics

  • Open Access

    Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen

    Iuliana V. Ene, Rhys A. Farrer, Matthew P. Hirakawa, Kennedy Agwamba, Christina A. Cuomo, and Richard J. Bennett

    PNAS September 11, 2018 115 (37) E8688-E8697; first published August 27, 2018. https://doi.org/10.1073/pnas.1806002115
  • Open Access

    Telomere shortening is a hallmark of genetic cardiomyopathies

    Alex C. Y. Chang, Andrew C. H. Chang, Anna Kirillova, Koki Sasagawa, Willis Su, Gerhard Weber, Jue Lin, Vittavat Termglinchan, Ioannis Karakikes, Timon Seeger, Alexandra M. Dainis, John T. Hinson, Jonathan Seidman, Christine E. Seidman, John W. Day, Euan Ashley, Joseph C. Wu, and Helen M. Blau

    PNAS September 11, 2018 115 (37) 9276-9281; first published August 27, 2018. https://doi.org/10.1073/pnas.1714538115

• Immunology and Inflammation

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    Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

    Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Yuto Mifune, Hexin Shi, Kuan-wen Wang, Xiaoming Zhan, Aijie Liu, Jianhui Wang, Xiaohong Li, Miao Tang, Sara Ludwig, Sara Hildebrand, Kejin Zhou, Daniel J. Siegwart, Eva Marie Y. Moresco, Hong Zhang, Dale L. Boger, and Bruce Beutler

    PNAS September 11, 2018 115 (37) E8698-E8706; first published August 27, 2018. https://doi.org/10.1073/pnas.1809232115
  • Open Access

    Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition

    Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, and Brian J. Sutton

    PNAS September 11, 2018 115 (37) E8707-E8716; first published August 27, 2018. https://doi.org/10.1073/pnas.1806840115

• Medical Sciences

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    Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood–tumor barrier disruption

    Costas D. Arvanitis, Vasileios Askoxylakis, Yutong Guo, Meenal Datta, Jonas Kloepper, Gino B. Ferraro, Miguel O. Bernabeu, Dai Fukumura, Nathan McDannold, and Rakesh K. Jain

    PNAS September 11, 2018 115 (37) E8717-E8726; first published August 27, 2018. https://doi.org/10.1073/pnas.1807105115
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    Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction

    • From the Cover

    Svenja Hinrichs, Katharina Scherschel, Saskia Krüger, Johannes Tobias Neumann, Michael Schwarzl, Isabell Yan, Svenja Warnke, Francisco M. Ojeda, Tanja Zeller, Mahir Karakas, Till Keller, Christian Meyer, Stefan Blankenberg, Dirk Westermann, and Diana Lindner

    PNAS September 11, 2018 115 (37) E8727-E8736; first published August 30, 2018. https://doi.org/10.1073/pnas.1721635115
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    Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma

    Roland Sonntag, Nives Giebeler, Yulia A. Nevzorova, Jörg-Martin Bangen, Dirk Fahrenkamp, Daniela Lambertz, Ute Haas, Wei Hu, Nikolaus Gassler, Francisco Javier Cubero, Gerhard Müller-Newen, Ali T. Abdallah, Ralf Weiskirchen, Fabio Ticconi, Ivan G. Costa, Mariano Barbacid, Christian Trautwein, and Christian Liedtke

    PNAS September 11, 2018 115 (37) 9282-9287; first published August 27, 2018. https://doi.org/10.1073/pnas.1807155115
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    Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation

    Michihito Kono, Nobuya Yoshida, Kayaho Maeda, Nicole E. Skinner, Wenliang Pan, Vasileios C. Kyttaris, Maria G. Tsokos, and George C. Tsokos

    PNAS September 11, 2018 115 (37) 9288-9293; first published August 27, 2018. https://doi.org/10.1073/pnas.1805717115

• Microbiology

  • Open Access

    Circular DNA tumor viruses make circular RNAs

    Tuna Toptan, Bizunesh Abere, Michael A. Nalesnik, Steven H. Swerdlow, Sarangarajan Ranganathan, Nara Lee, Kathy H. Shair, Patrick S. Moore, and Yuan Chang

    PNAS September 11, 2018 115 (37) E8737-E8745; first published August 27, 2018. https://doi.org/10.1073/pnas.1811728115

    See companion article:

    • Discovery of Kaposi’s sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA

      - Dec 11, 2018
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    Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua

    José Victor Zambrana, Fausto Bustos Carrillo, Raquel Burger-Calderon, Damaris Collado, Nery Sanchez, Sergio Ojeda, Jairo Carey Monterrey, Miguel Plazaola, Brenda Lopez, Sonia Arguello, Douglas Elizondo, William Aviles, Josefina Coloma, Guillermina Kuan, Angel Balmaseda, Aubree Gordon, and Eva Harris

    PNAS September 11, 2018 115 (37) 9294-9299; first published August 27, 2018. https://doi.org/10.1073/pnas.1804672115

• Neuroscience

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    Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

    Daniel W. Summers, Jeffrey Milbrandt, and Aaron DiAntonio

    PNAS September 11, 2018 115 (37) E8746-E8754; first published August 27, 2018. https://doi.org/10.1073/pnas.1806933115
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    Distinct roles of prefrontal and parietal areas in the encoding of attentional priority

    Panagiotis Sapountzis, Sofia Paneri, and Georgia G. Gregoriou

    PNAS September 11, 2018 115 (37) E8755-E8764; first published August 28, 2018. https://doi.org/10.1073/pnas.1804643115
  • Open Access

    Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition

    Florian A. Siebzehnrübl, Kerstin A. Raber, Yvonne K. Urbach, Anja Schulze-Krebs, Fabio Canneva, Sandra Moceri, Johanna Habermeyer, Dalila Achoui, Bhavana Gupta, Dennis A. Steindler, Michael Stephan, Huu Phuc Nguyen, Michael Bonin, Olaf Riess, Andreas Bauer, Ludwig Aigner, Sebastien Couillard-Despres, Martin Arce Paucar, Per Svenningsson, Alexander Osmand, Alexander Andreew, Claus Zabel, Andreas Weiss, Rainer Kuhn, Saliha Moussaoui, Ines Blockx, Annemie Van der Linden, Rachel Y. Cheong, Laurent Roybon, Åsa Petersén, and Stephan von Hörsten

    PNAS September 11, 2018 115 (37) E8765-E8774; first published August 27, 2018. https://doi.org/10.1073/pnas.1807962115
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    Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection

    Bastian Zimmer, Osefame Ewaleifoh, Oliver Harschnitz, Yoon-Seung Lee, Camille Peneau, Jessica L. McAlpine, Becky Liu, Jason Tchieu, Julius A. Steinbeck, Fabien Lafaille, Stefano Volpi, Luigi D. Notarangelo, Jean-Laurent Casanova, Shen-Ying Zhang, Gregory A. Smith, and Lorenz Studer

    PNAS September 11, 2018 115 (37) E8775-E8782; first published August 28, 2018. https://doi.org/10.1073/pnas.1809853115
  • Open Access

    Maps of subjective feelings

    Lauri Nummenmaa, Riitta Hari, Jari K. Hietanen, and Enrico Glerean

    PNAS September 11, 2018 115 (37) 9198-9203; first published August 28, 2018. https://doi.org/10.1073/pnas.1807390115
  • Open Access

    Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks

    Shuo Wang, Erik D. Herzog, István Z. Kiss, William J. Schwartz, Guy Bloch, Michael Sebek, Daniel Granados-Fuentes, Liang Wang, and Jr-Shin Li

    PNAS September 11, 2018 115 (37) 9300-9305; first published August 27, 2018. https://doi.org/10.1073/pnas.1721286115
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    Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex

    Cora Sau Wan Lai, Avital Adler, and Wen-Biao Gan

    PNAS September 11, 2018 115 (37) 9306-9311; first published August 27, 2018. https://doi.org/10.1073/pnas.1801504115
  • Open Access

    Neurobehavioral correlates of obesity are largely heritable

    Uku Vainik, Travis E. Baker, Mahsa Dadar, Yashar Zeighami, Andréanne Michaud, Yu Zhang, José C. García Alanis, Bratislav Misic, D. Louis Collins, and Alain Dagher

    PNAS September 11, 2018 115 (37) 9312-9317; first published August 28, 2018. https://doi.org/10.1073/pnas.1718206115

• Plant Biology

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    Transcriptional switch for programmed cell death in pith parenchyma of sorghum stems

    Masaru Fujimoto, Takashi Sazuka, Yoshihisa Oda, Hiroyuki Kawahigashi, Jianzhong Wu, Hideki Takanashi, Takayuki Ohnishi, Jun-ichi Yoneda, Motoyuki Ishimori, Hiromi Kajiya-Kanegae, Ken-ichiro Hibara, Fumiko Ishizuna, Kazuo Ebine, Takashi Ueda, Tsuyoshi Tokunaga, Hiroyoshi Iwata, Takashi Matsumoto, Shigemitsu Kasuga, Jun-ichi Yonemaru, and Nobuhiro Tsutsumi

    PNAS September 11, 2018 115 (37) E8783-E8792; first published August 27, 2018. https://doi.org/10.1073/pnas.1807501115
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    Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation

    Xueqin Li, C. Jake Harris, Zhenhui Zhong, Wei Chen, Rui Liu, Bei Jia, Zonghua Wang, Sisi Li, Steven E. Jacobsen, and Jiamu Du

    PNAS September 11, 2018 115 (37) E8793-E8802; first published August 27, 2018. https://doi.org/10.1073/pnas.1809841115

• Psychological and Cognitive Sciences

  • Open Access

    Default mode network can support the level of detail in experience during active task states

    Mladen Sormaz, Charlotte Murphy, Hao-ting Wang, Mark Hymers, Theodoros Karapanagiotidis, Giulia Poerio, Daniel S. Margulies, Elizabeth Jefferies, and Jonathan Smallwood

    PNAS September 11, 2018 115 (37) 9318-9323; first published August 27, 2018. https://doi.org/10.1073/pnas.1721259115

• Systems Biology

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    Feedback-mediated signal conversion promotes viral fitness

    Noam Vardi, Sonali Chaturvedi, and Leor S. Weinberger

    PNAS September 11, 2018 115 (37) E8803-E8810; first published August 27, 2018. https://doi.org/10.1073/pnas.1802905115