Proceedings of the National Academy of Sciences: 115 (37)

New Research In

September 11, 2018; vol. 115 no. 37

This Week in PNAS

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In This Issue
PNAS September 11, 2018 115 (37) 9045-9047; https://doi.org/10.1073/iti3718115

Letters (Online Only)

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Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors
Michael C. Haffner, Diana Taheri, Eddie Luidy-Imada, Doreen N. Palsgrove, Marie-Lisa Eich, George J. Netto, Andres Matoso, Thomas R. Nirschl, Qizhi Zheng, Jessica L. Hicks, William G. Nelson, Angelo M. De Marzo, Luigi Marchionni, Charles G. Drake, and Srinivasan Yegnasubramanian

PNAS September 11, 2018 115 (37) E8580-E8582; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1803292115
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Reply to Haffner et al.: DNA hypomethylation renders tumors more immunogenic
Meredith L. Stone, Katherine B. Chiappinelli, Huili Li, Lauren M. Murphy, Meghan E. Travers, Michael J. Topper, Dimitrios Mathios, Michael Lim, Ie-Ming Shih, Tian-Li Wang, Chien-Fu Hung, Vipul Bhargava, Karla R. Wiehagen, Glenn S. Cowley, Kurtis E. Bachman, Reiner Strick, Pamela L. Strissel, Stephen B. Baylin, and Cynthia A. Zahnow

PNAS September 11, 2018 115 (37) E8583-E8584; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1811015115

Science and Culture

How science intersects with culture.

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Science and Culture: Raw data videos offer a glimpse into laboratory research
Front Matter
Roberta Kwok

PNAS September 11, 2018 115 (37) 9048-9050; https://doi.org/10.1073/pnas.1813373115

Commentaries

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Unraveling the inner workings of respiratory arsenate reductase
John F. Stolz and Partha Basu

PNAS September 11, 2018 115 (37) 9051-9053; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1812841115
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Understanding refugee naturalization as partnership
Irene Bloemraad

PNAS September 11, 2018 115 (37) 9054-9056; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1812842115
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Gating currents indicate complex gating of voltage-gated proton channels
Thomas E. DeCoursey

PNAS September 11, 2018 115 (37) 9057-9059; published ahead of print August 22, 2018. https://doi.org/10.1073/pnas.1813013115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS September 11, 2018 115 (37) 9060-9064; https://doi.org/10.1073/pnas.ss11537

Perspective

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Moving beyond panaceas in fisheries governance
Oran R. Young, D. G. Webster, Michael E. Cox, Jesper Raakjær, Lau Øfjord Blaxekjær, Níels Einarsson, Ross A. Virginia, James Acheson, Daniel Bromley, Emma Cardwell, Courtney Carothers, Einar Eythórsson, Richard B. Howarth, Svein Jentoft, Bonnie J. McCay, Fiona McCormack, Gail Osherenko, Evelyn Pinkerton, Rob van Ginkel, James A. Wilson, Louie Rivers III, and Robyn S. Wilson

PNAS September 11, 2018 115 (37) 9065-9073; published ahead of print August 23, 2018. https://doi.org/10.1073/pnas.1716545115

Physical Sciences

Applied Mathematics
- Open Access
  Material barriers to diffusive and stochastic transport
  George Haller, Daniel Karrasch, and Florian Kogelbauer
  
  PNAS September 11, 2018 115 (37) 9074-9079; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1720177115
- Open Access
  Aversion to ambiguity and model misspecification in dynamic stochastic environments
  Lars Peter Hansen and Jianjun Miao
  
  PNAS September 11, 2018 115 (37) 9163-9168; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1811243115
Applied Physical Sciences
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  History of art paintings through the lens of entropy and complexity
  Higor Y. D. Sigaki, Matjaž Perc, and Haroldo V. Ribeiro
  
  PNAS September 11, 2018 115 (37) E8585-E8594; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1800083115
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  Absorption by water increases fluorescence image contrast of biological tissue in the shortwave infrared
  Jessica A. Carr, Marianne Aellen, Daniel Franke, Peter T. C. So, Oliver T. Bruns, and Moungi G. Bawendi
  
  PNAS September 11, 2018 115 (37) 9080-9085; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1803210115
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  Multivalent, multiflavored droplets by design
  Yin Zhang, Xiaojin He, Rebecca Zhuo, Ruojie Sha, Jasna Brujic, Nadrian C. Seeman, and Paul M. Chaikin
  
  PNAS September 11, 2018 115 (37) 9086-9091; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1718511115
Biophysics and Computational Biology
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  Feedback-mediated signal conversion promotes viral fitness
  Noam Vardi, Sonali Chaturvedi, and Leor S. Weinberger
  
  PNAS September 11, 2018 115 (37) E8803-E8810; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1802905115
- Open Access
  Protein evolution speed depends on its stability and abundance and on chaperone concentrations
  Luca Agozzino and Ken A. Dill
  
  PNAS September 11, 2018 115 (37) 9092-9097; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1810194115
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  Size and topology modulate the effects of frustration in protein folding
  Alex Kluber, Timothy A. Burt, and Cecilia Clementi
  
  PNAS September 11, 2018 115 (37) 9234-9239; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1801406115
- Open Access
  Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks
  Shuo Wang, Erik D. Herzog, István Z. Kiss, William J. Schwartz, Guy Bloch, Michael Sebek, Daniel Granados-Fuentes, Liang Wang, and Jr-Shin Li
  
  PNAS September 11, 2018 115 (37) 9300-9305; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1721286115
Chemistry
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  Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding
  Jesper J. Madsen, John M. A. Grime, Jeremy S. Rossman, and Gregory A. Voth
  
  PNAS September 11, 2018 115 (37) E8595-E8603; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1805443115
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  Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability
  Frank R. Moss III, Steven R. Shuken, Jaron A. M. Mercer, Carolyn M. Cohen, Thomas M. Weiss, Steven G. Boxer, and Noah Z. Burns
  
  PNAS September 11, 2018 115 (37) 9098-9103; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1810706115
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  Ligand “noninnocence” in coordination complexes vs. kinetic, mechanistic, and selectivity issues in electrochemical catalysis
  Cyrille Costentin, Jean-Michel Savéant, and Cédric Tard
  
  PNAS September 11, 2018 115 (37) 9104-9109; published ahead of print August 24, 2018. https://doi.org/10.1073/pnas.1810255115
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  Mechanics of elastomeric molecular composites
  Pierre Millereau, Etienne Ducrot, Jess M. Clough, Meredith E. Wiseman, Hugh R. Brown, Rint P. Sijbesma, and Costantino Creton
  
  PNAS September 11, 2018 115 (37) 9110-9115; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1807750115
Earth, Atmospheric, and Planetary Sciences
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  Dynamic process connectivity explains ecohydrologic responses to rainfall pulses and drought
  Allison E. Goodwell, Praveen Kumar, Aaron W. Fellows, and Gerald N. Flerchinger
  
  PNAS September 11, 2018 115 (37) E8604-E8613; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1800236115
- Open Access
  Impact of climate change on the transition of Neanderthals to modern humans in Europe
  Michael Staubwasser, Virgil Drăgușin, Bogdan P. Onac, Sergey Assonov, Vasile Ersek, Dirk L. Hoffmann, and Daniel Veres
  
  PNAS September 11, 2018 115 (37) 9116-9121; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1808647115
- Open Access
  Rapid growth of organic aerosol nanoparticles over a wide tropospheric temperature range
  Dominik Stolzenburg, Lukas Fischer, Alexander L. Vogel, Martin Heinritzi, Meredith Schervish, Mario Simon, Andrea C. Wagner, Lubna Dada, Lauri R. Ahonen, Antonio Amorim, Andrea Baccarini, Paulus S. Bauer, Bernhard Baumgartner, Anton Bergen, Federico Bianchi, Martin Breitenlechner, Sophia Brilke, Stephany Buenrostro Mazon, Dexian Chen, António Dias, Danielle C. Draper, Jonathan Duplissy, Imad El Haddad, Henning Finkenzeller, Carla Frege, Claudia Fuchs, Olga Garmash, Hamish Gordon, Xucheng He, Johanna Helm, Victoria Hofbauer, Christopher R. Hoyle, Changhyuk Kim, Jasper Kirkby, Jenni Kontkanen, Andreas Kürten, Janne Lampilahti, Michael Lawler, Katrianne Lehtipalo, Markus Leiminger, Huajun Mai, Serge Mathot, Bernhard Mentler, Ugo Molteni, Wei Nie, Tuomo Nieminen, John B. Nowak, Andrea Ojdanic, Antti Onnela, Monica Passananti, Tuukka Petäjä, Lauriane L. J. Quéléver, Matti P. Rissanen, Nina Sarnela, Simon Schallhart, Christian Tauber, António Tomé, Robert Wagner, Mingyi Wang, Lena Weitz, Daniela Wimmer, Mao Xiao, Chao Yan, Penglin Ye, Qiaozhi Zha, Urs Baltensperger, Joachim Curtius, Josef Dommen, Richard C. Flagan, Markku Kulmala, James N. Smith, Douglas R. Worsnop, Armin Hansel, Neil M. Donahue, and Paul M. Winkler
  
  PNAS September 11, 2018 115 (37) 9122-9127; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1807604115
- Open Access
  Multiproxy evidence for leaf-browsing and closed habitats in extinct proboscideans (Mammalia, Proboscidea) from Central Chile
  Erwin González-Guarda, Alia Petermann-Pichincura, Carlos Tornero, Laura Domingo, Jordi Agustí, Mario Pino, Ana M. Abarzúa, José M. Capriles, Natalia A. Villavicencio, Rafael Labarca, Violeta Tolorza, Paloma Sevilla, and Florent Rivals
  
  PNAS September 11, 2018 115 (37) 9258-9263; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1804642115
Engineering
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  Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood–tumor barrier disruption
  Costas D. Arvanitis, Vasileios Askoxylakis, Yutong Guo, Meenal Datta, Jonas Kloepper, Gino B. Ferraro, Miguel O. Bernabeu, Dai Fukumura, Nathan McDannold, and Rakesh K. Jain
  
  PNAS September 11, 2018 115 (37) E8717-E8726; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807105115
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  Simultaneous improvements of strength and toughness in topologically interlocked ceramics
  Mohammad Mirkhalaf, Tao Zhou, and Francois Barthelat
  
  PNAS September 11, 2018 115 (37) 9128-9133; published ahead of print August 23, 2018. https://doi.org/10.1073/pnas.1807272115
Environmental Sciences
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  Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations
  From the Cover
  
  Nathaniel R. Glasser, Paul H. Oyala, Thomas H. Osborne, Joanne M. Santini, and Dianne K. Newman
  
  PNAS September 11, 2018 115 (37) E8614-E8623; published ahead of print August 13, 2018. https://doi.org/10.1073/pnas.1807984115
Physics
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  Lifetime dynamics of plasmons in the few-atom limit
  Kyle D. Chapkin, Luca Bursi, Grant J. Stec, Adam Lauchner, Nathaniel J. Hogan, Yao Cui, Peter Nordlander, and Naomi J. Halas
  
  PNAS September 11, 2018 115 (37) 9134-9139; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1805357115
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  Anomalous Hall effect in Weyl semimetal half-Heusler compounds RPtBi (R = Gd and Nd)
  Chandra Shekhar, Nitesh Kumar, V. Grinenko, Sanjay Singh, R. Sarkar, H. Luetkens, Shu-Chun Wu, Yang Zhang, Alexander C. Komarek, Erik Kampert, Yurii Skourski, Jochen Wosnitza, Walter Schnelle, Alix McCollam, Uli Zeitler, Jürgen Kübler, Binghai Yan, H.-H. Klauss, S. S. P. Parkin, and C. Felser
  
  PNAS September 11, 2018 115 (37) 9140-9144; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1810842115
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  Vanishing quantum oscillations in Dirac semimetal ZrTe₅
  Jingyue Wang, Jingjing Niu, Baoming Yan, Xinqi Li, Ran Bi, Yuan Yao, Dapeng Yu, and Xiaosong Wu
  
  PNAS September 11, 2018 115 (37) 9145-9150; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1804958115
Statistics
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  Projection pursuit in high dimensions
  Peter J. Bickel, Gil Kur, and Boaz Nadler
  
  PNAS September 11, 2018 115 (37) 9151-9156; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1801177115
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  Asymptotic theory of rerandomization in treatment–control experiments
  Xinran Li, Peng Ding, and Donald B. Rubin
  
  PNAS September 11, 2018 115 (37) 9157-9162; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1808191115

Biological Sciences

Applied Biological Sciences
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  Simultaneous improvements of strength and toughness in topologically interlocked ceramics
  Mohammad Mirkhalaf, Tao Zhou, and Francois Barthelat
  
  PNAS September 11, 2018 115 (37) 9128-9133; published ahead of print August 23, 2018. https://doi.org/10.1073/pnas.1807272115
Biochemistry
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  Structural and mechanistic analysis of the arsenate respiratory reductase provides insight into environmental arsenic transformations
  From the Cover
  
  Nathaniel R. Glasser, Paul H. Oyala, Thomas H. Osborne, Joanne M. Santini, and Dianne K. Newman
  
  PNAS September 11, 2018 115 (37) E8614-E8623; published ahead of print August 13, 2018. https://doi.org/10.1073/pnas.1807984115
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  β-Subunit of the voltage-gated Ca²⁺ channel Cav1.2 drives signaling to the nucleus via H-Ras
  Evrim Servili, Michael Trus, Daphne Maayan, and Daphne Atlas
  
  PNAS September 11, 2018 115 (37) E8624-E8633; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1805380115
- Open Access
  De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug
  Jason Lancaster, Ashot Khrimian, Sharon Young, Bryan Lehner, Katrin Luck, Anna Wallingford, Saikat Kumar B. Ghosh, Philipp Zerbe, Andrew Muchlinski, Paul E. Marek, Michael E. Sparks, James G. Tokuhisa, Claus Tittiger, Tobias G. Köllner, Donald C. Weber, Dawn E. Gundersen-Rindal, Thomas P. Kuhar, and Dorothea Tholl
  
  PNAS September 11, 2018 115 (37) E8634-E8641; published ahead of print August 23, 2018. https://doi.org/10.1073/pnas.1800008115
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  Molecular strategy for blocking isopeptide bond formation in nascent pilin proteins
  Jaime Andrés Rivas-Pardo, Carmen L. Badilla, Rafael Tapia-Rojo, Álvaro Alonso-Caballero, and Julio M. Fernández
  
  PNAS September 11, 2018 115 (37) 9222-9227; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807689115
- Open Access
  Methylglyoxal-derived posttranslational arginine modifications are abundant histone marks
  James J. Galligan, James A. Wepy, Matthew D. Streeter, Philip J. Kingsley, Michelle M. Mitchener, Orrette R. Wauchope, William N. Beavers, Kristie L. Rose, Tina Wang, David A. Spiegel, and Lawrence J. Marnett
  
  PNAS September 11, 2018 115 (37) 9228-9233; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1802901115
Biophysics and Computational Biology
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  Entropic forces drive clustering and spatial localization of influenza A M2 during viral budding
  Jesper J. Madsen, John M. A. Grime, Jeremy S. Rossman, and Gregory A. Voth
  
  PNAS September 11, 2018 115 (37) E8595-E8603; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1805443115
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  Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA, and actin filaments
  Sofia Espinoza-Sanchez, Lauren Ann Metskas, Steven Z. Chou, Elizabeth Rhoades, and Thomas D. Pollard
  
  PNAS September 11, 2018 115 (37) E8642-E8651; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1717594115
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  QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities
  Shuguang Zhang, Fei Tao, Rui Qing, Hongzhi Tang, Michael Skuhersky, Karolina Corin, Lotta Tegler, Asmamaw Wassie, Brook Wassie, Yongwon Kwon, Bernhard Suter, Clemens Entzian, Thomas Schubert, Ge Yang, Jörg Labahn, Jan Kubicek, and Barbara Maertens
  
  PNAS September 11, 2018 115 (37) E8652-E8659; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1811031115
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  Ladderane phospholipids form a densely packed membrane with normal hydrazine and anomalously low proton/hydroxide permeability
  Frank R. Moss III, Steven R. Shuken, Jaron A. M. Mercer, Carolyn M. Cohen, Thomas M. Weiss, Steven G. Boxer, and Noah Z. Burns
  
  PNAS September 11, 2018 115 (37) 9098-9103; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1810706115
- You have access
  Size and topology modulate the effects of frustration in protein folding
  Alex Kluber, Timothy A. Burt, and Cecilia Clementi
  
  PNAS September 11, 2018 115 (37) 9234-9239; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1801406115
- You have access
  Gating charge displacement in a monomeric voltage-gated proton (H_v1) channel
  From the Cover
  
  Emerson M. Carmona, H. Peter Larsson, Alan Neely, Osvaldo Alvarez, Ramon Latorre, and Carlos Gonzalez
  
  PNAS September 11, 2018 115 (37) 9240-9245; published ahead of print August 20, 2018. https://doi.org/10.1073/pnas.1809705115
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  Architecture of cell–cell adhesion mediated by sidekicks
  Hua Tang, Haishuang Chang, Yue Dong, Luqiang Guo, Xiangyi Shi, Yichun Wu, Ying Huang, and Yongning He
  
  PNAS September 11, 2018 115 (37) 9246-9251; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1801810115
Cell Biology
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  Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells
  Abu Shufian Ishtiaq Ahmed, Kunzhe Dong, Jinhua Liu, Tong Wen, Luyi Yu, Fei Xu, Xiuhua Kang, Islam Osman, Guoqing Hu, Kristopher M. Bunting, Danielle Crethers, Hongyu Gao, Wei Zhang, Yunlong Liu, Ke Wen, Gautam Agarwal, Tetsuro Hirose, Shinichi Nakagawa, Almira Vazdarjanova, and Jiliang Zhou
  
  PNAS September 11, 2018 115 (37) E8660-E8667; published ahead of print August 23, 2018. https://doi.org/10.1073/pnas.1803725115
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  BRAF/MAPK and GSK3 signaling converges to control MITF nuclear export
  Kao Chin Ngeow, Hans J. Friedrichsen, Linxin Li, Zhiqiang Zeng, Sarah Andrews, Laurent Volpon, Hannah Brunsdon, Georgina Berridge, Sarah Picaud, Roman Fischer, Richard Lisle, Stefan Knapp, Panagis Filippakopoulos, Helen Knowles, Eiríkur Steingrímsson, Katherine L. B. Borden, E. Elizabeth Patton, and Colin R. Goding
  
  PNAS September 11, 2018 115 (37) E8668-E8677; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1810498115
Developmental Biology
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  Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132
  Jamie L. Lahvic, Michelle Ammerman, Pulin Li, Megan C. Blair, Emma R. Stillman, Eva M. Fast, Anne L. Robertson, Constantina Christodoulou, Julie R. Perlin, Song Yang, Nan Chiang, Paul C. Norris, Madeleine L. Daily, Shelby E. Redfield, Iris T. Chan, Mona Chatrizeh, Michael E. Chase, Olivia Weis, Yi Zhou, Charles N. Serhan, and Leonard I. Zon
  
  PNAS September 11, 2018 115 (37) 9252-9257; published ahead of print August 23, 2018. https://doi.org/10.1073/pnas.1806077115
Ecology
- Open Access
  Multiproxy evidence for leaf-browsing and closed habitats in extinct proboscideans (Mammalia, Proboscidea) from Central Chile
  Erwin González-Guarda, Alia Petermann-Pichincura, Carlos Tornero, Laura Domingo, Jordi Agustí, Mario Pino, Ana M. Abarzúa, José M. Capriles, Natalia A. Villavicencio, Rafael Labarca, Violeta Tolorza, Paloma Sevilla, and Florent Rivals
  
  PNAS September 11, 2018 115 (37) 9258-9263; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1804642115
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  Responses to pup vocalizations in subordinate naked mole-rats are induced by estradiol ingested through coprophagy of queen’s feces
  Akiyuki Watarai, Natsuki Arai, Shingo Miyawaki, Hideyuki Okano, Kyoko Miura, Kazutaka Mogi, and Takefumi Kikusui
  
  PNAS September 11, 2018 115 (37) 9264-9269; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1720530115
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  Remoteness promotes biological invasions on islands worldwide
  Dietmar Moser, Bernd Lenzner, Patrick Weigelt, Wayne Dawson, Holger Kreft, Jan Pergl, Petr Pyšek, Mark van Kleunen, Marten Winter, César Capinha, Phillip Cassey, Stefan Dullinger, Evan P. Economo, Pablo García-Díaz, Benoit Guénard, Florian Hofhansl, Thomas Mang, Hanno Seebens, and Franz Essl
  
  PNAS September 11, 2018 115 (37) 9270-9275; published ahead of print August 29, 2018. https://doi.org/10.1073/pnas.1804179115
Environmental Sciences
- You have access
  Dynamic process connectivity explains ecohydrologic responses to rainfall pulses and drought
  Allison E. Goodwell, Praveen Kumar, Aaron W. Fellows, and Gerald N. Flerchinger
  
  PNAS September 11, 2018 115 (37) E8604-E8613; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1800236115
Evolution
- Open Access
  Physical foundations of biological complexity
  Yuri I. Wolf, Mikhail I. Katsnelson, and Eugene V. Koonin
  
  PNAS September 11, 2018 115 (37) E8678-E8687; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807890115
- Open Access
  Protein evolution speed depends on its stability and abundance and on chaperone concentrations
  Luca Agozzino and Ken A. Dill
  
  PNAS September 11, 2018 115 (37) 9092-9097; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1810194115
Genetics
- Open Access
  Global analysis of mutations driving microevolution of a heterozygous diploid fungal pathogen
  Iuliana V. Ene, Rhys A. Farrer, Matthew P. Hirakawa, Kennedy Agwamba, Christina A. Cuomo, and Richard J. Bennett
  
  PNAS September 11, 2018 115 (37) E8688-E8697; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1806002115
- Open Access
  Telomere shortening is a hallmark of genetic cardiomyopathies
  Alex C. Y. Chang, Andrew C. H. Chang, Anna Kirillova, Koki Sasagawa, Willis Su, Gerhard Weber, Jue Lin, Vittavat Termglinchan, Ioannis Karakikes, Timon Seeger, Alexandra M. Dainis, John T. Hinson, Jonathan Seidman, Christine E. Seidman, John W. Day, Euan Ashley, Joseph C. Wu, and Helen M. Blau
  
  PNAS September 11, 2018 115 (37) 9276-9281; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1714538115
Immunology and Inflammation
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  Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice
  Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Yuto Mifune, Hexin Shi, Kuan-wen Wang, Xiaoming Zhan, Aijie Liu, Jianhui Wang, Xiaohong Li, Miao Tang, Sara Ludwig, Sara Hildebrand, Kejin Zhou, Daniel J. Siegwart, Eva Marie Y. Moresco, Hong Zhang, Dale L. Boger, and Bruce Beutler
  
  PNAS September 11, 2018 115 (37) E8698-E8706; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1809232115
- Open Access
  Structure of a patient-derived antibody in complex with allergen reveals simultaneous conventional and superantigen-like recognition
  Alkistis N. Mitropoulou, Holly Bowen, Tihomir S. Dodev, Anna M. Davies, Heather J. Bax, Rebecca L. Beavil, Andrew J. Beavil, Hannah J. Gould, Louisa K. James, and Brian J. Sutton
  
  PNAS September 11, 2018 115 (37) E8707-E8716; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1806840115
Medical Sciences
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  Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood–tumor barrier disruption
  Costas D. Arvanitis, Vasileios Askoxylakis, Yutong Guo, Meenal Datta, Jonas Kloepper, Gino B. Ferraro, Miguel O. Bernabeu, Dai Fukumura, Nathan McDannold, and Rakesh K. Jain
  
  PNAS September 11, 2018 115 (37) E8717-E8726; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807105115
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  Precursor proadrenomedullin influences cardiomyocyte survival and local inflammation related to myocardial infarction
  From the Cover
  
  Svenja Hinrichs, Katharina Scherschel, Saskia Krüger, Johannes Tobias Neumann, Michael Schwarzl, Isabell Yan, Svenja Warnke, Francisco M. Ojeda, Tanja Zeller, Mahir Karakas, Till Keller, Christian Meyer, Stefan Blankenberg, Dirk Westermann, and Diana Lindner
  
  PNAS September 11, 2018 115 (37) E8727-E8736; published ahead of print August 30, 2018. https://doi.org/10.1073/pnas.1721635115
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  Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma
  Roland Sonntag, Nives Giebeler, Yulia A. Nevzorova, Jörg-Martin Bangen, Dirk Fahrenkamp, Daniela Lambertz, Ute Haas, Wei Hu, Nikolaus Gassler, Francisco Javier Cubero, Gerhard Müller-Newen, Ali T. Abdallah, Ralf Weiskirchen, Fabio Ticconi, Ivan G. Costa, Mariano Barbacid, Christian Trautwein, and Christian Liedtke
  
  PNAS September 11, 2018 115 (37) 9282-9287; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807155115
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  Pyruvate dehydrogenase phosphatase catalytic subunit 2 limits Th17 differentiation
  Michihito Kono, Nobuya Yoshida, Kayaho Maeda, Nicole E. Skinner, Wenliang Pan, Vasileios C. Kyttaris, Maria G. Tsokos, and George C. Tsokos
  
  PNAS September 11, 2018 115 (37) 9288-9293; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1805717115
Microbiology
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  Circular DNA tumor viruses make circular RNAs
  Tuna Toptan, Bizunesh Abere, Michael A. Nalesnik, Steven H. Swerdlow, Sarangarajan Ranganathan, Nara Lee, Kathy H. Shair, Patrick S. Moore, and Yuan Chang
  
  PNAS September 11, 2018 115 (37) E8737-E8745; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1811728115
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  Seroprevalence, risk factor, and spatial analyses of Zika virus infection after the 2016 epidemic in Managua, Nicaragua
  José Victor Zambrana, Fausto Bustos Carrillo, Raquel Burger-Calderon, Damaris Collado, Nery Sanchez, Sergio Ojeda, Jairo Carey Monterrey, Miguel Plazaola, Brenda Lopez, Sonia Arguello, Douglas Elizondo, William Aviles, Josefina Coloma, Guillermina Kuan, Angel Balmaseda, Aubree Gordon, and Eva Harris
  
  PNAS September 11, 2018 115 (37) 9294-9299; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1804672115
Neuroscience
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  Palmitoylation enables MAPK-dependent proteostasis of axon survival factors
  Daniel W. Summers, Jeffrey Milbrandt, and Aaron DiAntonio
  
  PNAS September 11, 2018 115 (37) E8746-E8754; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1806933115
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  Distinct roles of prefrontal and parietal areas in the encoding of attentional priority
  Panagiotis Sapountzis, Sofia Paneri, and Georgia G. Gregoriou
  
  PNAS September 11, 2018 115 (37) E8755-E8764; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1804643115
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  Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition
  Florian A. Siebzehnrübl, Kerstin A. Raber, Yvonne K. Urbach, Anja Schulze-Krebs, Fabio Canneva, Sandra Moceri, Johanna Habermeyer, Dalila Achoui, Bhavana Gupta, Dennis A. Steindler, Michael Stephan, Huu Phuc Nguyen, Michael Bonin, Olaf Riess, Andreas Bauer, Ludwig Aigner, Sebastien Couillard-Despres, Martin Arce Paucar, Per Svenningsson, Alexander Osmand, Alexander Andreew, Claus Zabel, Andreas Weiss, Rainer Kuhn, Saliha Moussaoui, Ines Blockx, Annemie Van der Linden, Rachel Y. Cheong, Laurent Roybon, Åsa Petersén, and Stephan von Hörsten
  
  PNAS September 11, 2018 115 (37) E8765-E8774; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807962115
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  Human iPSC-derived trigeminal neurons lack constitutive TLR3-dependent immunity that protects cortical neurons from HSV-1 infection
  Bastian Zimmer, Osefame Ewaleifoh, Oliver Harschnitz, Yoon-Seung Lee, Camille Peneau, Jessica L. McAlpine, Becky Liu, Jason Tchieu, Julius A. Steinbeck, Fabien Lafaille, Stefano Volpi, Luigi D. Notarangelo, Jean-Laurent Casanova, Shen-Ying Zhang, Gregory A. Smith, and Lorenz Studer
  
  PNAS September 11, 2018 115 (37) E8775-E8782; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1809853115
- Open Access
  Maps of subjective feelings
  Lauri Nummenmaa, Riitta Hari, Jari K. Hietanen, and Enrico Glerean
  
  PNAS September 11, 2018 115 (37) 9198-9203; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1807390115
- Open Access
  Inferring dynamic topology for decoding spatiotemporal structures in complex heterogeneous networks
  Shuo Wang, Erik D. Herzog, István Z. Kiss, William J. Schwartz, Guy Bloch, Michael Sebek, Daniel Granados-Fuentes, Liang Wang, and Jr-Shin Li
  
  PNAS September 11, 2018 115 (37) 9300-9305; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1721286115
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  Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex
  Cora Sau Wan Lai, Avital Adler, and Wen-Biao Gan
  
  PNAS September 11, 2018 115 (37) 9306-9311; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1801504115
- Open Access
  Neurobehavioral correlates of obesity are largely heritable
  Uku Vainik, Travis E. Baker, Mahsa Dadar, Yashar Zeighami, Andréanne Michaud, Yu Zhang, José C. García Alanis, Bratislav Misic, D. Louis Collins, and Alain Dagher
  
  PNAS September 11, 2018 115 (37) 9312-9317; published ahead of print August 28, 2018. https://doi.org/10.1073/pnas.1718206115
Plant Biology
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  Transcriptional switch for programmed cell death in pith parenchyma of sorghum stems
  Masaru Fujimoto, Takashi Sazuka, Yoshihisa Oda, Hiroyuki Kawahigashi, Jianzhong Wu, Hideki Takanashi, Takayuki Ohnishi, Jun-ichi Yoneda, Motoyuki Ishimori, Hiromi Kajiya-Kanegae, Ken-ichiro Hibara, Fumiko Ishizuna, Kazuo Ebine, Takashi Ueda, Tsuyoshi Tokunaga, Hiroyoshi Iwata, Takashi Matsumoto, Shigemitsu Kasuga, Jun-ichi Yonemaru, and Nobuhiro Tsutsumi
  
  PNAS September 11, 2018 115 (37) E8783-E8792; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1807501115
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  Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation
  Xueqin Li, C. Jake Harris, Zhenhui Zhong, Wei Chen, Rui Liu, Bei Jia, Zonghua Wang, Sisi Li, Steven E. Jacobsen, and Jiamu Du
  
  PNAS September 11, 2018 115 (37) E8793-E8802; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1809841115
Psychological and Cognitive Sciences
- Open Access
  Default mode network can support the level of detail in experience during active task states
  Mladen Sormaz, Charlotte Murphy, Hao-ting Wang, Mark Hymers, Theodoros Karapanagiotidis, Giulia Poerio, Daniel S. Margulies, Elizabeth Jefferies, and Jonathan Smallwood
  
  PNAS September 11, 2018 115 (37) 9318-9323; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1721259115
Systems Biology
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  Feedback-mediated signal conversion promotes viral fitness
  Noam Vardi, Sonali Chaturvedi, and Leor S. Weinberger
  
  PNAS September 11, 2018 115 (37) E8803-E8810; published ahead of print August 27, 2018. https://doi.org/10.1073/pnas.1802905115

Corrections (Online Only)

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Correction for Tsigkou et al., Engineered vascularized bone grafts
PNAS September 11, 2018 115 (37) E8811; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1813106115
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Correction for Tomasini et al., TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity
PNAS September 11, 2018 115 (37) E8812; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1814112115

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Correction to Supporting Information for Delvendahl et al., Reduced endogenous Ca²⁺ buffering speeds active zone Ca²⁺ signaling
PNAS September 11, 2018 115 (37) E8813-E8814; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1813283115

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