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Edited by Dennis A. Carson, University of California, San Diego, La Jolla, CA, and approved July 2, 2018 (received for review June 28, 2018)
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- Published in issue September 11, 2018.
- Published first August 27, 2018.
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- Previous version (August 27, 2018 - 11:49).
- You are viewing the most recent version of this article.
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Author Information
- Ying Wanga,
- Lijing Sua,
- Matthew D. Morinb,
- Brian T. Jonesb,
- Yuto Mifuneb,
- Hexin Shia,
- Kuan-wen Wanga,
- Xiaoming Zhana,
- Aijie Liua,
- Jianhui Wanga,
- Xiaohong Lia,
- Miao Tanga,
- Sara Ludwiga,
- Sara Hildebranda,
- Kejin Zhouc,d,
- Daniel J. Siegwartc,d,
- Eva Marie Y. Morescoa,
- Hong Zhanga,
- Dale L. Bogerb, and
- Bruce Beutlera,1
- aCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;
- bDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;
- cSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
- dDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390
Edited by Dennis A. Carson, University of California, San Diego, La Jolla, CA, and approved July 2, 2018 (received for review June 28, 2018)
Footnotes
- ↵1To whom correspondence should be addressed. Email: bruce.beutler{at}utsouthwestern.edu.
Author contributions: Y.W. and B.B. designed research; Y.W., L.S., H.S., K.-w.W., X.Z., A.L., J.W., X.L., M.T., S.L., S.H., K.Z., D.J.S., and H.Z. performed research; M.D.M., B.T.J., Y.M., and D.L.B. contributed new reagents/analytic tools; Y.W. and B.B. analyzed data; and Y.W., E.M.Y.M., and B.B. wrote the paper.
Conflict of interest statement: B.B. and D.L.B. have financial interests in Tollbridge Therapeutics, LLC, which has licensed the patent for Diprovocim.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1809232115/-/DCSupplemental.
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Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice
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