Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice

Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Yuto Mifune, Hexin Shi, Kuan-wen Wang, Xiaoming Zhan, Aijie Liu, Jianhui Wang, Xiaohong Li, Miao Tang, Sara Ludwig, Sara Hildebrand, Kejin Zhou, Daniel J. Siegwart, Eva Marie Y. Moresco, Hong Zhang, Dale L. Boger, and Bruce Beutler
PNAS September 11, 2018 115 (37) E8698-E8706; published ahead of print August 27, 2018 https://doi.org/10.1073/pnas.1809232115

  1. Edited by Dennis A. Carson, University of California, San Diego, La Jolla, CA, and approved July 2, 2018 (received for review June 28, 2018)

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Article Information

vol. 115 no. 37 E8698-E8706
DOI: 
https://doi.org/10.1073/pnas.1809232115
PubMed: 
30150374
Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue September 11, 2018.
  • Published first August 27, 2018.
Copyright & Usage: 
© 2018 Published under the PNAS license.

Author Information

  1. Ying Wanga,
  2. Lijing Sua,
  3. Matthew D. Morinb,
  4. Brian T. Jonesb,
  5. Yuto Mifuneb,
  6. Hexin Shia,
  7. Kuan-wen Wanga,
  8. Xiaoming Zhana,
  9. Aijie Liua,
  10. Jianhui Wanga,
  11. Xiaohong Lia,
  12. Miao Tanga,
  13. Sara Ludwiga,
  14. Sara Hildebranda,
  15. Kejin Zhouc,d,
  16. Daniel J. Siegwartc,d,
  17. Eva Marie Y. Morescoa,
  18. Hong Zhanga,
  19. Dale L. Bogerb, and
  20. Bruce Beutlera,1
  1. aCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;
  2. bDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;
  3. cSimmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390;
  4. dDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390

  1. Edited by Dennis A. Carson, University of California, San Diego, La Jolla, CA, and approved July 2, 2018 (received for review June 28, 2018)

Footnotes

  • ↵1To whom correspondence should be addressed. Email: bruce.beutler{at}utsouthwestern.edu.

  • Author contributions: Y.W. and B.B. designed research; Y.W., L.S., H.S., K.-w.W., X.Z., A.L., J.W., X.L., M.T., S.L., S.H., K.Z., D.J.S., and H.Z. performed research; M.D.M., B.T.J., Y.M., and D.L.B. contributed new reagents/analytic tools; Y.W. and B.B. analyzed data; and Y.W., E.M.Y.M., and B.B. wrote the paper.

  • Conflict of interest statement: B.B. and D.L.B. have financial interests in Tollbridge Therapeutics, LLC, which has licensed the patent for Diprovocim.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1809232115/-/DCSupplemental.

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Aug 2018921174131
Sep 20182613722441133
Oct 20182902502268
Nov 20181315227120
Dec 201883115575
Total 20183210633021727
Jan 201989818198
Feb 20193614742
Total 20191259228140
Total3336535301867
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Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti–PD-L1 to eliminate melanoma in mice
Ying Wang, Lijing Su, Matthew D. Morin, Brian T. Jones, Yuto Mifune, Hexin Shi, Kuan-wen Wang, Xiaoming Zhan, Aijie Liu, Jianhui Wang, Xiaohong Li, Miao Tang, Sara Ludwig, Sara Hildebrand, Kejin Zhou, Daniel J. Siegwart, Eva Marie Y. Moresco, Hong Zhang, Dale L. Boger, Bruce Beutler
Proceedings of the National Academy of Sciences Sep 2018, 115 (37) E8698-E8706; DOI: 10.1073/pnas.1809232115
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