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Research Article

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

View ORCID ProfileDavid Møbjerg Kristensen, Christèle Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbøl, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesné, Séverine Mazaud-Guittot, View ORCID ProfileKarsten Kristiansen, Søren Brunak, Michael Kjaer, Anders Juul, and Bernard Jégou
PNAS January 23, 2018 115 (4) E715-E724; first published January 8, 2018; https://doi.org/10.1073/pnas.1715035115
David Møbjerg Kristensen
aDanish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark;
bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
cNovo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200 Copenhagen, Denmark;
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  • ORCID record for David Møbjerg Kristensen
  • For correspondence: david.moebjerg.boslev.kristensen@regionh.dk bernard.jegou@inserm.fr
Christèle Desdoits-Lethimonier
bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
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Abigail L. Mackey
dInstitute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark;
eCenter for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
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Marlene Danner Dalgaard
fDTU Bio and Health Informatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark;
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Federico De Masi
fDTU Bio and Health Informatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark;
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Cecilie Hurup Munkbøl
gDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
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Bjarne Styrishave
gDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
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Jean-Philippe Antignac
hL'Université Nantes Angers Le Mans (LUNAM), Oniris, UMR 1329 INRA Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), F-44307 Nantes, France;
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Bruno Le Bizec
hL'Université Nantes Angers Le Mans (LUNAM), Oniris, UMR 1329 INRA Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), F-44307 Nantes, France;
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Christian Platel
iUnité de coordination hospitalière des prélèvements d’organes et de tissus, Centre Hospitalier Universitaire de Rennes, 35000 Rennes, France;
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Anders Hay-Schmidt
jDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
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Tina Kold Jensen
kDepartment of Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark;
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Laurianne Lesné
bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
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Séverine Mazaud-Guittot
bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
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Karsten Kristiansen
lDepartment of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark;
mInstitute of Metagenomics, BGI-Shenzhen, Shenzhen 518083, China;
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  • ORCID record for Karsten Kristiansen
Søren Brunak
aDanish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark;
cNovo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200 Copenhagen, Denmark;
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Michael Kjaer
dInstitute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark;
eCenter for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
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Anders Juul
nDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark;
oEDMaRC (International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health), Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark
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Bernard Jégou
bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
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  • For correspondence: david.moebjerg.boslev.kristensen@regionh.dk bernard.jegou@inserm.fr
  1. Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 1, 2017 (received for review August 31, 2017)

This article has a Correction. Please see:

  • Correction for Kristensen et al., Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism - April 16, 2018
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Article Information

vol. 115 no. 4 E715-E724
DOI: 
https://doi.org/10.1073/pnas.1715035115
PubMed: 
29311296

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue January 23, 2018.
  • Published first January 8, 2018.

Article Versions

  • Previous version (January 8, 2018 - 11:59).
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Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. David Møbjerg Kristensena,b,c,1,2,
  2. Christèle Desdoits-Lethimonierb,1,
  3. Abigail L. Mackeyd,e,
  4. Marlene Danner Dalgaardf,
  5. Federico De Masif,
  6. Cecilie Hurup Munkbølg,
  7. Bjarne Styrishaveg,
  8. Jean-Philippe Antignach,
  9. Bruno Le Bizech,
  10. Christian Plateli,
  11. Anders Hay-Schmidtj,
  12. Tina Kold Jensenk,
  13. Laurianne Lesnéb,
  14. Séverine Mazaud-Guittotb,
  15. Karsten Kristiansenl,m,
  16. Søren Brunaka,c,
  17. Michael Kjaerd,e,
  18. Anders Juuln,o, and
  19. Bernard Jégoub,2
  1. aDanish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark;
  2. bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
  3. cNovo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200 Copenhagen, Denmark;
  4. dInstitute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark;
  5. eCenter for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
  6. fDTU Bio and Health Informatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark;
  7. gDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
  8. hL'Université Nantes Angers Le Mans (LUNAM), Oniris, UMR 1329 INRA Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), F-44307 Nantes, France;
  9. iUnité de coordination hospitalière des prélèvements d’organes et de tissus, Centre Hospitalier Universitaire de Rennes, 35000 Rennes, France;
  10. jDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
  11. kDepartment of Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark;
  12. lDepartment of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark;
  13. mInstitute of Metagenomics, BGI-Shenzhen, Shenzhen 518083, China;
  14. nDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark;
  15. oEDMaRC (International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health), Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark
  1. Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 1, 2017 (received for review August 31, 2017)

Footnotes

  • ↵1D.M.K. and C.D.-L. contributed equally to this work.

  • ↵2To whom correspondence may be addressed. Email: david.moebjerg.boslev.kristensen{at}regionh.dk or bernard.jegou{at}inserm.fr.
  • Author contributions: D.M.K., C.D.-L., A.L.M., M.D.D., S.M.-G., M.K., A.J., and B.J. designed research; D.M.K., C.D.-L., A.L.M., M.D.D., C.H.H., B.S., J.-P.A., B.L.B., C.P., L.L., S.M.-G., M.K., and A.J. performed research; D.M.K., S.B., and B.J. contributed new reagents/analytic tools; D.M.K., C.D.-L., F.D.M., C.H.H., B.S., J.-P.A., B.L.B., C.P., A.H.-S., T.K.J., L.L., S.M.-G., K.K., S.B., M.K., A.J., and B.J. analyzed data; and D.M.K., C.D.-L., and B.J. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1715035115/-/DCSupplemental.

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Jan 20187833516971610172
Feb 201810270155971277
Mar 20181056412823870
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NSAID ibuprofen alters human testicular function
David Møbjerg Kristensen, Christèle Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbøl, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesné, Séverine Mazaud-Guittot, Karsten Kristiansen, Søren Brunak, Michael Kjaer, Anders Juul, Bernard Jégou
Proceedings of the National Academy of Sciences Jan 2018, 115 (4) E715-E724; DOI: 10.1073/pnas.1715035115

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NSAID ibuprofen alters human testicular function
David Møbjerg Kristensen, Christèle Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbøl, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesné, Séverine Mazaud-Guittot, Karsten Kristiansen, Søren Brunak, Michael Kjaer, Anders Juul, Bernard Jégou
Proceedings of the National Academy of Sciences Jan 2018, 115 (4) E715-E724; DOI: 10.1073/pnas.1715035115
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Proceedings of the National Academy of Sciences: 115 (4)
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