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Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism
Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 1, 2017 (received for review August 31, 2017)
This article has a Correction. Please see:

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Article Information
- Published in issue January 23, 2018.
- Published first January 8, 2018.
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- Previous version (January 8, 2018 - 11:59).
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Author Information
- David Møbjerg Kristensena,b,c,1,2,
- Christèle Desdoits-Lethimonierb,1,
- Abigail L. Mackeyd,e,
- Marlene Danner Dalgaardf,
- Federico De Masif,
- Cecilie Hurup Munkbølg,
- Bjarne Styrishaveg,
- Jean-Philippe Antignach,
- Bruno Le Bizech,
- Christian Plateli,
- Anders Hay-Schmidtj,
- Tina Kold Jensenk,
- Laurianne Lesnéb,
- Séverine Mazaud-Guittotb,
- Karsten Kristiansenl,m,
- Søren Brunaka,c,
- Michael Kjaerd,e,
- Anders Juuln,o, and
- Bernard Jégoub,2
- aDanish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark;
- bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
- cNovo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200 Copenhagen, Denmark;
- dInstitute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark;
- eCenter for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
- fDTU Bio and Health Informatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark;
- gDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
- hL'Université Nantes Angers Le Mans (LUNAM), Oniris, UMR 1329 INRA Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), F-44307 Nantes, France;
- iUnité de coordination hospitalière des prélèvements d’organes et de tissus, Centre Hospitalier Universitaire de Rennes, 35000 Rennes, France;
- jDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
- kDepartment of Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark;
- lDepartment of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark;
- mInstitute of Metagenomics, BGI-Shenzhen, Shenzhen 518083, China;
- nDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark;
- oEDMaRC (International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health), Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark
Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 1, 2017 (received for review August 31, 2017)
Footnotes
↵1D.M.K. and C.D.-L. contributed equally to this work.
- ↵2To whom correspondence may be addressed. Email: david.moebjerg.boslev.kristensen{at}regionh.dk or bernard.jegou{at}inserm.fr.
Author contributions: D.M.K., C.D.-L., A.L.M., M.D.D., S.M.-G., M.K., A.J., and B.J. designed research; D.M.K., C.D.-L., A.L.M., M.D.D., C.H.H., B.S., J.-P.A., B.L.B., C.P., L.L., S.M.-G., M.K., and A.J. performed research; D.M.K., S.B., and B.J. contributed new reagents/analytic tools; D.M.K., C.D.-L., F.D.M., C.H.H., B.S., J.-P.A., B.L.B., C.P., A.H.-S., T.K.J., L.L., S.M.-G., K.K., S.B., M.K., A.J., and B.J. analyzed data; and D.M.K., C.D.-L., and B.J. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1715035115/-/DCSupplemental.
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