Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

David Møbjerg Kristensen, Christèle Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbøl, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesné, Séverine Mazaud-Guittot, Karsten Kristiansen, Søren Brunak, Michael Kjaer, Anders Juul, and Bernard Jégou
PNAS January 23, 2018 115 (4) E715-E724; first published January 8, 2018 https://doi.org/10.1073/pnas.1715035115

  1. Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 1, 2017 (received for review August 31, 2017)

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Article Information

vol. 115 no. 4 E715-E724
DOI: 
https://doi.org/10.1073/pnas.1715035115
PubMed: 
29311296
Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue January 23, 2018.
  • Published first January 8, 2018.
Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. David Møbjerg Kristensena,b,c,1,2,
  2. Christèle Desdoits-Lethimonierb,1,
  3. Abigail L. Mackeyd,e,
  4. Marlene Danner Dalgaardf,
  5. Federico De Masif,
  6. Cecilie Hurup Munkbølg,
  7. Bjarne Styrishaveg,
  8. Jean-Philippe Antignach,
  9. Bruno Le Bizech,
  10. Christian Plateli,
  11. Anders Hay-Schmidtj,
  12. Tina Kold Jensenk,
  13. Laurianne Lesnéb,
  14. Séverine Mazaud-Guittotb,
  15. Karsten Kristiansenl,m,
  16. Søren Brunaka,c,
  17. Michael Kjaerd,e,
  18. Anders Juuln,o, and
  19. Bernard Jégoub,2
  1. aDanish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark;
  2. bUniversité de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR_S 1085, F-35000 Rennes, France;
  3. cNovo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200 Copenhagen, Denmark;
  4. dInstitute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark;
  5. eCenter for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
  6. fDTU Bio and Health Informatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark;
  7. gDepartment of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
  8. hL'Université Nantes Angers Le Mans (LUNAM), Oniris, UMR 1329 INRA Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), F-44307 Nantes, France;
  9. iUnité de coordination hospitalière des prélèvements d’organes et de tissus, Centre Hospitalier Universitaire de Rennes, 35000 Rennes, France;
  10. jDepartment of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark;
  11. kDepartment of Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark;
  12. lDepartment of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark;
  13. mInstitute of Metagenomics, BGI-Shenzhen, Shenzhen 518083, China;
  14. nDepartment of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark;
  15. oEDMaRC (International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health), Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark

  1. Edited by David W. Russell, University of Texas Southwestern Medical Center, Dallas, TX, and approved December 1, 2017 (received for review August 31, 2017)

Footnotes

  • ↵1D.M.K. and C.D.-L. contributed equally to this work.

  • ↵2To whom correspondence may be addressed. Email: david.moebjerg.boslev.kristensen{at}regionh.dk or bernard.jegou{at}inserm.fr.

  • Author contributions: D.M.K., C.D.-L., A.L.M., M.D.D., S.M.-G., M.K., A.J., and B.J. designed research; D.M.K., C.D.-L., A.L.M., M.D.D., C.H.H., B.S., J.-P.A., B.L.B., C.P., L.L., S.M.-G., M.K., and A.J. performed research; D.M.K., S.B., and B.J. contributed new reagents/analytic tools; D.M.K., C.D.-L., F.D.M., C.H.H., B.S., J.-P.A., B.L.B., C.P., A.H.-S., T.K.J., L.L., S.M.-G., K.K., S.B., M.K., A.J., and B.J. analyzed data; and D.M.K., C.D.-L., and B.J. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1715035115/-/DCSupplemental.

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Article usage: January 2018 to July 2019

AbstractFullPdf
Jan 20187833516971610172
Feb 201810270155971277
Mar 20181056412823870
Apr 201839095819493
May 201826073843257
Jun 201836884383240
Jul 201821872712230
Aug 201851605758183
Sep 201818542263221
Oct 20181722832217
Nov 2018322013234
Dec 20182930852669
Total 201811880725861115063
Jan 20198816499801
Feb 2019865270337
Mar 2019812316228
Apr 2019781844164
May 20191231814154
Jun 2019471643118
Jul 20198580498
Total 2019588301901900
Total11939528880116963
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NSAID ibuprofen alters human testicular function
David Møbjerg Kristensen, Christèle Desdoits-Lethimonier, Abigail L. Mackey, Marlene Danner Dalgaard, Federico De Masi, Cecilie Hurup Munkbøl, Bjarne Styrishave, Jean-Philippe Antignac, Bruno Le Bizec, Christian Platel, Anders Hay-Schmidt, Tina Kold Jensen, Laurianne Lesné, Séverine Mazaud-Guittot, Karsten Kristiansen, Søren Brunak, Michael Kjaer, Anders Juul, Bernard Jégou
Proceedings of the National Academy of Sciences Jan 2018, 115 (4) E715-E724; DOI: 10.1073/pnas.1715035115
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