Proceedings of the National Academy of Sciences: 115 (41)

New Research In

October 09, 2018; vol. 115 no. 41

This Week in PNAS

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In This Issue
PNAS October 9, 2018 115 (41) 10185-10187; https://doi.org/10.1073/iti4118115

Letters (Online Only)

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Accurate timetrees require accurate calibrations
S. Blair Hedges, Qiqing Tao, Mark Walker, and Sudhir Kumar

PNAS October 9, 2018 115 (41) E9510-E9511; published ahead of print September 28, 2018. https://doi.org/10.1073/pnas.1812558115
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Reply to Hedges et al.: Accurate timetrees do indeed require accurate calibrations
Jennifer L. Morris, Mark N. Puttick, James W. Clark, Dianne Edwards, Paul Kenrick, Silvia Pressel, Charles H. Wellman, Ziheng Yang, Harald Schneider, and Philip C. J. Donoghue

PNAS October 9, 2018 115 (41) E9512-E9513; published ahead of print September 28, 2018. https://doi.org/10.1073/pnas.1812816115

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: The mysterious parentage of the coveted black truffle
Front Matter
Amber Dance

PNAS October 9, 2018 115 (41) 10188-10190; https://doi.org/10.1073/pnas.1814128115

Profile

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Profile of Jonathan D. G. Jones
Jennifer Viegas

PNAS October 9, 2018 115 (41) 10191-10194; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1815072115

Commentaries

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Ryanodine receptor cluster size sets the tone in cerebral smooth muscle
Christian Soeller

PNAS October 9, 2018 115 (41) 10195-10197; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1814207115
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Direct visualization of ion-channel gating in a native environment
Yvonne Gicheru and Sudha Chakrapani

PNAS October 9, 2018 115 (41) 10198-10200; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1814277115
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Collusion between neutralizing antibodies and other immune factions in the destruction of adenoviral vectors
P. J. Klasse

PNAS October 9, 2018 115 (41) 10201-10203; published ahead of print September 19, 2018. https://doi.org/10.1073/pnas.1814275115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS October 9, 2018 115 (41) 10204-10208; https://doi.org/10.1073/pnas.ss11541

Perspective

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Identity and novelty in the avian syrinx
Evan P. Kingsley, Chad M. Eliason, Tobias Riede, Zhiheng Li, Tom W. Hiscock, Michael Farnsworth, Scott L. Thomson, Franz Goller, Clifford J. Tabin, and Julia A. Clarke

PNAS October 9, 2018 115 (41) 10209-10217; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1804586115

Physical Sciences

Applied Mathematics
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  Symmetric coalescence of two hydraulic fractures
  Niall J. O’Keeffe, Zhong Zheng, Herbert E. Huppert, and P. F. Linden
  
  PNAS October 9, 2018 115 (41) 10228-10232; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1809233115
Applied Physical Sciences
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  Stable Frank–Kasper phases of self-assembled, soft matter spheres
  Abhiram Reddy, Michael B. Buckley, Akash Arora, Frank S. Bates, Kevin D. Dorfman, and Gregory M. Grason
  
  PNAS October 9, 2018 115 (41) 10233-10238; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1809655115
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  Crimping-induced structural gradients explain the lasting strength of poly l-lactide bioresorbable vascular scaffolds during hydrolysis
  Karthik Ramachandran, Tiziana Di Luccio, Artemis Ailianou, Mary Beth Kossuth, James P. Oberhauser, and Julia A. Kornfield
  
  PNAS October 9, 2018 115 (41) 10239-10244; published ahead of print September 17, 2018. https://doi.org/10.1073/pnas.1807347115
Biophysics and Computational Biology
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  Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools
  Svetlana A. Kholodar, Ananda K. Ghosh, Katarzyna Świderek, Vicent Moliner, and Amnon Kohen
  
  PNAS October 9, 2018 115 (41) 10311-10314; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1811059115
Chemistry
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  Phevamine A, a small molecule that suppresses plant immune responses
  Erinn M. O’Neill, Tatiana S. Mucyn, Jon B. Patteson, Omri M. Finkel, Eui-Hwan Chung, Joshua A. Baccile, Elisabetta Massolo, Frank C. Schroeder, Jeffery L. Dangl, and Bo Li
  
  PNAS October 9, 2018 115 (41) E9514-E9522; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1803779115
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  Energy-dependent quenching adjusts the excitation diffusion length to regulate photosynthetic light harvesting
  Doran I. G. Bennett, Graham R. Fleming, and Kapil Amarnath
  
  PNAS October 9, 2018 115 (41) E9523-E9531; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1806597115
- Open Access
  SAR by kinetics for drug discovery in protein misfolding diseases
  Sean Chia, Johnny Habchi, Thomas C. T. Michaels, Samuel I. A. Cohen, Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, and Michele Vendruscolo
  
  PNAS October 9, 2018 115 (41) 10245-10250; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1807884115
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  Predicting polymorphism in molecular crystals using orientational entropy
  Pablo M. Piaggi and Michele Parrinello
  
  PNAS October 9, 2018 115 (41) 10251-10256; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1811056115
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  Revised M06 density functional for main-group and transition-metal chemistry
  Ying Wang, Pragya Verma, Xinsheng Jin, Donald G. Truhlar, and Xiao He
  
  PNAS October 9, 2018 115 (41) 10257-10262; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1810421115
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  Two-dimensional dry ices with rich polymorphic and polyamorphic phase behavior
  Jaeil Bai, Joseph S. Francisco, and Xiao Cheng Zeng
  
  PNAS October 9, 2018 115 (41) 10263-10268; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1809198115
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  Multiscale wavelet decomposition of time-resolved X-ray diffraction signals in cyclohexadiene
  Vladimir Al. Osipov, Markus Kowalewski, and Shaul Mukamel
  
  PNAS October 9, 2018 115 (41) 10269-10274; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1811983115
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  Interferometric plasmonic imaging and detection of single exosomes
  Yuting Yang, Guangxia Shen, Hui Wang, Hongxia Li, Ting Zhang, Nongjian Tao, Xianting Ding, and Hui Yu
  
  PNAS October 9, 2018 115 (41) 10275-10280; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1804548115
Earth, Atmospheric, and Planetary Sciences
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  Use of scenario ensembles for deriving seismic risk
  Tom R. Robinson, Nicholas J. Rosser, Alexander L. Densmore, Katie J. Oven, Surya N. Shrestha, and Ramesh Guragain
  
  PNAS October 9, 2018 115 (41) E9532-E9541; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1807433115
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  Sediment starvation destroys New York City marshes’ resistance to sea level rise
  Dorothy M. Peteet, Jonathan Nichols, Timothy Kenna, Clara Chang, James Browne, Mohammad Reza, Stephen Kovari, Louisa Liberman, and Stephanie Stern-Protz
  
  PNAS October 9, 2018 115 (41) 10281-10286; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1715392115
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  Origin and significance of Si and O isotope heterogeneities in Phanerozoic, Archean, and Hadean zircon
  Dustin Trail, Patrick Boehnke, Paul S. Savage, Ming-Chang Liu, Martha L. Miller, and Ilya Bindeman
  
  PNAS October 9, 2018 115 (41) 10287-10292; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1808335115
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  Earth’s outgoing longwave radiation linear due to H₂O greenhouse effect
  Daniel D. B. Koll and Timothy W. Cronin
  
  PNAS October 9, 2018 115 (41) 10293-10298; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1809868115
Engineering
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  Conductively coupled flexible silicon electronic systems for chronic neural electrophysiology
  From the Cover
  
  Jinghua Li, Enming Song, Chia-Han Chiang, Ki Jun Yu, Jahyun Koo, Haina Du, Yishan Zhong, Mackenna Hill, Charles Wang, Jize Zhang, Yisong Chen, Limei Tian, Yiding Zhong, Guanhua Fang, Jonathan Viventi, and John A. Rogers
  
  PNAS October 9, 2018 115 (41) E9542-E9549; published ahead of print September 18, 2018. https://doi.org/10.1073/pnas.1813187115
Mathematics
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  Mechanics of mouse blastocyst hatching revealed by a hydrogel-based microdeformation assay
  Karolis Leonavicius, Christophe Royer, Chris Preece, Benjamin Davies, John S. Biggins, and Shankar Srinivas
  
  PNAS October 9, 2018 115 (41) 10375-10380; published ahead of print September 19, 2018. https://doi.org/10.1073/pnas.1719930115
Statistics
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  Generalized least squares can overcome the critical threshold in respondent-driven sampling
  Sebastien Roch and Karl Rohe
  
  PNAS October 9, 2018 115 (41) 10299-10304; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1706699115

Biological Sciences

Applied Biological Sciences
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  Glyphosate perturbs the gut microbiota of honey bees
  Erick V. S. Motta, Kasie Raymann, and Nancy A. Moran
  
  PNAS October 9, 2018 115 (41) 10305-10310; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1803880115
Biochemistry
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  ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation
  Donghoon Lee, Shinichi Takayama, and Alfred L. Goldberg
  
  PNAS October 9, 2018 115 (41) E9550-E9559; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1809934115
- Open Access
  ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB
  Hongjun Yu, Tania J. Lupoli, Amanda Kovach, Xing Meng, Gongpu Zhao, Carl F. Nathan, and Huilin Li
  
  PNAS October 9, 2018 115 (41) E9560-E9569; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1810648115
- Open Access
  Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools
  Svetlana A. Kholodar, Ananda K. Ghosh, Katarzyna Świderek, Vicent Moliner, and Amnon Kohen
  
  PNAS October 9, 2018 115 (41) 10311-10314; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1811059115
- Open Access
  Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function
  Leslie W. Glustrom, Kenneth R. Lyon, Margherita Paschini, Cynthia M. Reyes, Nicholas V. Parsonnet, Tasha B. Toro, Victoria Lundblad, and Deborah S. Wuttke
  
  PNAS October 9, 2018 115 (41) 10315-10320; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1722147115
Biophysics and Computational Biology
- Open Access
  SAR by kinetics for drug discovery in protein misfolding diseases
  Sean Chia, Johnny Habchi, Thomas C. T. Michaels, Samuel I. A. Cohen, Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, and Michele Vendruscolo
  
  PNAS October 9, 2018 115 (41) 10245-10250; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1807884115
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  On the control of the proton current in the voltage-gated proton channel Hv1
  Myungjin Lee, Chen Bai, Mikolaj Feliks, Raphael Alhadeff, and Arieh Warshel
  
  PNAS October 9, 2018 115 (41) 10321-10326; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1809766115
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  Exploring the free-energy landscape of GPCR activation
  Raphael Alhadeff, Igor Vorobyov, Han Wool Yoon, and Arieh Warshel
  
  PNAS October 9, 2018 115 (41) 10327-10332; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1810316115
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  Structural titration of receptor ion channel GLIC gating by HS-AFM
  From the Cover
  
  Yi Ruan, Kevin Kao, Solène Lefebvre, Arin Marchesi, Pierre-Jean Corringer, Richard K. Hite, and Simon Scheuring
  
  PNAS October 9, 2018 115 (41) 10333-10338; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1805621115
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  The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation
  Krishna Chinthalapudi, Erumbi S. Rangarajan, and Tina Izard
  
  PNAS October 9, 2018 115 (41) 10339-10344; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1806275115
- Open Access
  Structural evidence for the roles of divalent cations in actin polymerization and activation of ATP hydrolysis
  Clement P. M. Scipion, Umesh Ghoshdastider, Fernando J. Ferrer, Tsz-Ying Yuen, Jantana Wongsantichon, and Robert C. Robinson
  
  PNAS October 9, 2018 115 (41) 10345-10350; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1806394115
Cell Biology
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  Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis
  Guan-Yu Xiao, Aparna Mohanakrishnan, and Sandra L. Schmid
  
  PNAS October 9, 2018 115 (41) E9570-E9579; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1810209115
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  ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis
  Jordan M. Reese, Elizabeth S. Bruinsma, Adam W. Nelson, Igor Chernukhin, Jason S. Carroll, Ying Li, Malayannan Subramaniam, Vera J. Suman, Vivian Negron, David G. Monroe, James N. Ingle, Matthew P. Goetz, and John R. Hawse
  
  PNAS October 9, 2018 115 (41) E9580-E9589; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1807751115
- Open Access
  Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils
  Andreas Noack, Birthe Gericke, Maren von Köckritz-Blickwede, Arne Menze, Sandra Noack, Ingo Gerhauser, Felix Osten, Hassan Y. Naim, and Wolfgang Löscher
  
  PNAS October 9, 2018 115 (41) E9590-E9599; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1719642115
- Open Access
  BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
  Andrew G. Li, Elizabeth C. Murphy, Aedin C. Culhane, Emily Powell, Hua Wang, Roderick T. Bronson, Thanh Von, Anita Giobbie-Hurder, Rebecca S. Gelman, Kimberly J. Briggs, Helen Piwnica-Worms, Jean J. Zhao, Andrew L. Kung, William G. Kaelin Jr., and David M. Livingston
  
  PNAS October 9, 2018 115 (41) E9600-E9609; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1807112115
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  VEGF-B is a potent antioxidant
  Pachiappan Arjunan, Xianchai Lin, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Shasha Wang, Haiqing Kuang, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao, and Xuri Li
  
  PNAS October 9, 2018 115 (41) 10351-10356; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1801379115
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  PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice
  Laura Jamrog, Guillaume Chemin, Vincent Fregona, Lucie Coster, Marlène Pasquet, Chloé Oudinet, Nelly Rouquié, Naïs Prade, Stéphanie Lagarde, Charlotte Cresson, Sylvie Hébrard, Ngoc Sa Nguyen Huu, Marina Bousquet, Cathy Quelen, Pierre Brousset, Stéphane J. C. Mancini, Eric Delabesse, Ahmed Amine Khamlichi, Bastien Gerby, and Cyril Broccardo
  
  PNAS October 9, 2018 115 (41) 10357-10362; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1721678115
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  The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation
  Tetsuya Kotani, Hiromi Kirisako, Michiko Koizumi, Yoshinori Ohsumi, and Hitoshi Nakatogawa
  
  PNAS October 9, 2018 115 (41) 10363-10368; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1806727115
- Open Access
  Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle
  Balázs Kiss, Eun-Jeong Lee, Weikang Ma, Frank W. Li, Paola Tonino, Srboljub M. Mijailovich, Thomas C. Irving, and Henk L. Granzier
  
  PNAS October 9, 2018 115 (41) 10369-10374; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1804726115
Developmental Biology
- Open Access
  Mechanics of mouse blastocyst hatching revealed by a hydrogel-based microdeformation assay
  Karolis Leonavicius, Christophe Royer, Chris Preece, Benjamin Davies, John S. Biggins, and Shankar Srinivas
  
  PNAS October 9, 2018 115 (41) 10375-10380; published ahead of print September 19, 2018. https://doi.org/10.1073/pnas.1719930115
- Open Access
  Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis
  Suk-Hyun Hong, Sungsoon Fang, Benson C. Lu, Russell Nofsinger, Yasuhiko Kawakami, Glenda L. Castro, Yunqiang Yin, Chengqi Lin, Ruth T. Yu, Michael Downes, Juan Carlos Izpisúa Belmonte, Ali Shilatifard, and Ronald M. Evans
  
  PNAS October 9, 2018 115 (41) 10381-10386; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1809480115
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  Role of transcription complexes in the formation of the basal methylation pattern in early development
  Razi Greenfield, Amalia Tabib, Ilana Keshet, Joshua Moss, Ofra Sabag, Alon Goren, and Howard Cedar
  
  PNAS October 9, 2018 115 (41) 10387-10391; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1804755115
Ecology
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  Sediment starvation destroys New York City marshes’ resistance to sea level rise
  Dorothy M. Peteet, Jonathan Nichols, Timothy Kenna, Clara Chang, James Browne, Mohammad Reza, Stephen Kovari, Louisa Liberman, and Stephanie Stern-Protz
  
  PNAS October 9, 2018 115 (41) 10281-10286; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1715392115
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  Contrasting dynamics and trait controls in first-order root compared with leaf litter decomposition
  Tao Sun, Sarah E. Hobbie, Björn Berg, Hongguang Zhang, Qingkui Wang, Zhengwen Wang, and Stephan Hättenschwiler
  
  PNAS October 9, 2018 115 (41) 10392-10397; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1716595115
Evolution
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  Versatility of multivalent orientation, inverted meiosis, and rescued fitness in holocentric chromosomal hybrids
  From the Cover
  
  Vladimir A. Lukhtanov, Vlad Dincă, Magne Friberg, Jindra Šíchová, Martin Olofsson, Roger Vila, František Marec, and Christer Wiklund
  
  PNAS October 9, 2018 115 (41) E9610-E9619; published ahead of print September 28, 2018. https://doi.org/10.1073/pnas.1802610115
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  Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)
  Xu Wang, Lenore Pipes, Lyudmila N. Trut, Yury Herbeck, Anastasiya V. Vladimirova, Rimma G. Gulevich, Anastasiya V. Kharlamova, Jennifer L. Johnson, Gregory M. Acland, Anna V. Kukekova, and Andrew G. Clark
  
  PNAS October 9, 2018 115 (41) 10398-10403; published ahead of print September 18, 2018. https://doi.org/10.1073/pnas.1800889115
Genetics
- Open Access
  Mutations of mitochondrial DNA are not major contributors to aging of fruit flies
  Timo E. S. Kauppila, Ana Bratic, Martin Borch Jensen, Francesca Baggio, Linda Partridge, Heinrich Jasper, Sebastian Grönke, and Nils-Göran Larsson
  
  PNAS October 9, 2018 115 (41) E9620-E9629; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1721683115
Immunology and Inflammation
- Open Access
  Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function
  Virginia Andreani, Senthilkumar Ramamoorthy, Abhinav Pandey, Ekaterina Lupar, Stephen L. Nutt, Tim Lämmermann, and Rudolf Grosschedl
  
  PNAS October 9, 2018 115 (41) E9630-E9639; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1809739115
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  MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype
  Emilie Plantamura, Amiran Dzutsev, Mathias Chamaillard, Sophia Djebali, Lyvia Moudombi, Lilia Boucinha, Morgan Grau, Claire Macari, David Bauché, Oana Dumitrescu, Jean-Philippe Rasigade, Saskia Lippens, Michelina Plateroti, Elsa Kress, Annabelle Cesaro, Clovis Bondu, Ulrike Rothermel, Mathias Heikenwälder, Gerard Lina, Azzak Bentaher-Belaaouaj, Julien C. Marie, Christophe Caux, Giorgio Trinchieri, Jacqueline Marvel, and Marie-Cecile Michallet
  
  PNAS October 9, 2018 115 (41) 10404-10409; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1722372115
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  Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells
  Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki, and Jack D. Bui
  
  PNAS October 9, 2018 115 (41) 10410-10415; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1804108115
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  Optimal protection against Salmonella infection requires noncirculating memory
  Joseph M. Benoun, Newton G. Peres, Nancy Wang, Oanh H. Pham, Victoria L. Rudisill, Zachary N. Fogassy, Paul G. Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Quynh-Mai Pham, Lynn Puddington, Sammy Bedoui, Richard A. Strugnell, and Stephen J. McSorley
  
  PNAS October 9, 2018 115 (41) 10416-10421; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1808339115
Medical Sciences
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  Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
  Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, and Gregg L. Semenza
  
  PNAS October 9, 2018 115 (41) E9640-E9648; published ahead of print September 21, 2018. https://doi.org/10.1073/pnas.1809695115
Microbiology
- Open Access
  Phevamine A, a small molecule that suppresses plant immune responses
  Erinn M. O’Neill, Tatiana S. Mucyn, Jon B. Patteson, Omri M. Finkel, Eui-Hwan Chung, Joshua A. Baccile, Elisabetta Massolo, Frank C. Schroeder, Jeffery L. Dangl, and Bo Li
  
  PNAS October 9, 2018 115 (41) E9514-E9522; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1803779115
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  Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections
  Mario D. Garcia, Sheena M. H. Chua, Yu-Shang Low, Yu-Ting Lee, Kylie Agnew-Francis, Jian-Guo Wang, Amanda Nouwens, Thierry Lonhienne, Craig M. Williams, James A. Fraser, and Luke W. Guddat
  
  PNAS October 9, 2018 115 (41) E9649-E9658; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1809422115
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  IL-15 regulates susceptibility of CD4⁺ T cells to HIV infection
  Lara Manganaro, Patrick Hong, Matthew M. Hernandez, Dionne Argyle, Lubbertus C. F. Mulder, Uma Potla, Felipe Diaz-Griffero, Benhur Lee, Ana Fernandez-Sesma, and Viviana Simon
  
  PNAS October 9, 2018 115 (41) E9659-E9667; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1806695115
- Open Access
  Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia
  Meriam Guellil, Oliver Kersten, Amine Namouchi, Egil L. Bauer, Michael Derrick, Anne Ø. Jensen, Nils C. Stenseth, and Barbara Bramanti
  
  PNAS October 9, 2018 115 (41) 10422-10427; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1807266115
- Open Access
  Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella
  Francesca Micoli, Simona Rondini, Renzo Alfini, Luisa Lanzilao, Francesca Necchi, Aurel Negrea, Omar Rossi, Cornelia Brandt, Simon Clare, Pietro Mastroeni, Rino Rappuoli, Allan Saul, and Calman A. MacLennan
  
  PNAS October 9, 2018 115 (41) 10428-10433; published ahead of print September 27, 2018. https://doi.org/10.1073/pnas.1807655115
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  Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model
  Timokratis Karamitros, Tara Hurst, Emanuele Marchi, Eirini Karamichali, Urania Georgopoulou, Andreas Mentis, Joey Riepsaame, Audrey Lin, Dimitrios Paraskevis, Angelos Hatzakis, John McLauchlan, Aris Katzourakis, and Gkikas Magiorkinis
  
  PNAS October 9, 2018 115 (41) 10434-10439; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1811940115
- Open Access
  TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination
  From the Cover
  
  Maria Bottermann, Stian Foss, Laurens M. van Tienen, Marina Vaysburd, James Cruickshank, Kevin O’Connell, Jessica Clark, Keith Mayes, Katie Higginson, Jack C. Hirst, Martin B. McAdam, Greg Slodkowicz, Edward Hutchinson, Patrycja Kozik, Jan Terje Andersen, and Leo C. James
  
  PNAS October 9, 2018 115 (41) 10440-10445; published ahead of print September 12, 2018. https://doi.org/10.1073/pnas.1806314115
Neuroscience
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  Let-7i inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia
  Trinh Nguyen, Chang Su, and Meharvan Singh
  
  PNAS October 9, 2018 115 (41) E9668-E9677; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1803384115
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  FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models
  Jianwen Deng, Peng Wang, Xiaoping Chen, Haipeng Cheng, Jianghong Liu, Kazuo Fushimi, Li Zhu, and Jane Y. Wu
  
  PNAS October 9, 2018 115 (41) E9678-E9686; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1806655115
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  Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease
  Sarah K. Baker, Zu-Lin Chen, Erin H. Norris, Alexey S. Revenko, A. Robert MacLeod, and Sidney Strickland
  
  PNAS October 9, 2018 115 (41) E9687-E9696; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1811172115
- Open Access
  Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons
  Benita Turner-Bridger, Maximillian Jakobs, Leila Muresan, Hovy Ho-Wai Wong, Kristian Franze, William A. Harris, and Christine E. Holt
  
  PNAS October 9, 2018 115 (41) E9697-E9706; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1806189115
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  Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice
  Jingqi Yan, Morgan W. Porch, Brenda Court-Vazquez, Michael V. L. Bennett, and R. Suzanne Zukin
  
  PNAS October 9, 2018 115 (41) E9707-E9716; published ahead of print September 21, 2018. https://doi.org/10.1073/pnas.1808247115
- Open Access
  ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins
  Hourinaz Behesti, Taylor R. Fore, Peter Wu, Zachi Horn, Mary Leppert, Court Hull, and Mary E. Hatten
  
  PNAS October 9, 2018 115 (41) E9717-E9726; published ahead of print September 21, 2018. https://doi.org/10.1073/pnas.1809382115
- Open Access
  Genetically defined cellular correlates of the baseline brain MRI signal
  Jie Wen, Manu S. Goyal, Serguei V. Astafiev, Marcus E. Raichle, and Dmitriy A. Yablonskiy
  
  PNAS October 9, 2018 115 (41) E9727-E9736; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1808121115
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  Neural basis of location-specific pupil luminance modulation
  Chin-An Wang and Douglas P. Munoz
  
  PNAS October 9, 2018 115 (41) 10446-10451; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1809668115
- Open Access
  Movement kinematics drive chain selection toward intention detection
  Marco Soriano, Andrea Cavallo, Alessandro D’Ausilio, Cristina Becchio, and Luciano Fadiga
  
  PNAS October 9, 2018 115 (41) 10452-10457; published ahead of print September 21, 2018. https://doi.org/10.1073/pnas.1809825115
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  A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice
  Takato Honda, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, and Masashi Yanagisawa
  
  PNAS October 9, 2018 115 (41) 10458-10463; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1810823115
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  Axonal plasticity associated with perceptual learning in adult macaque primary visual cortex
  Timo van Kerkoerle, Sally A. Marik, Stephan Meyer zum Alten Borgloh, and Charles D. Gilbert
  
  PNAS October 9, 2018 115 (41) 10464-10469; published ahead of print September 27, 2018. https://doi.org/10.1073/pnas.1812932115
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  Desert ants possess distinct memories for food and nest odors
  Roman Huber and Markus Knaden
  
  PNAS October 9, 2018 115 (41) 10470-10474; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1809433115
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  Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium
  Lei Xu, Li Kong, Jiangang Wang, and John D. Ash
  
  PNAS October 9, 2018 115 (41) 10475-10480; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1802724115
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  Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
  Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, Francisca Pinheiro, Danilo González, Anita Carija, Susanna Navarro, María Conde-Giménez, Jesús García, Salvador Guardiola, Ernest Giralt, Xavier Salvatella, Javier Sancho, Mariona Sodupe, Tiago Fleming Outeiro, Esther Dalfó, and Salvador Ventura
  
  PNAS October 9, 2018 115 (41) 10481-10486; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1804198115
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  Rapid stimulation of human dentate gyrus function with acute mild exercise
  Kazuya Suwabe, Kyeongho Byun, Kazuki Hyodo, Zachariah M. Reagh, Jared M. Roberts, Akira Matsushita, Kousaku Saotome, Genta Ochi, Takemune Fukuie, Kenji Suzuki, Yoshiyuki Sankai, Michael A. Yassa, and Hideaki Soya
  
  PNAS October 9, 2018 115 (41) 10487-10492; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1805668115
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  Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice
  Marie A. Labouesse, Andrea M. Sartori, Oliver Weinmann, Eleanor H. Simpson, Christoph Kellendonk, and Ulrike Weber-Stadlbauer
  
  PNAS October 9, 2018 115 (41) 10493-10498; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1800171115
- Open Access
  Bottom-up saliency and top-down learning in the primary visual cortex of monkeys
  Yin Yan, Li Zhaoping, and Wu Li
  
  PNAS October 9, 2018 115 (41) 10499-10504; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1803854115
- Open Access
  Functionally specific optogenetic modulation in primate visual cortex
  Mykyta M. Chernov, Robert M. Friedman, Gang Chen, Gene R. Stoner, and Anna Wang Roe
  
  PNAS October 9, 2018 115 (41) 10505-10510; published ahead of print September 26, 2018. https://doi.org/10.1073/pnas.1802018115
Pharmacology
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  l-Serine–modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier
  Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Hidetaka Hayashi, Kazuhiro Koshino, Takahiro Higuchi, Yusuke Yagi, Hiroyuki Kimura, Toshiyasu Sakane, and Akira Yamamoto
  
  PNAS October 9, 2018 115 (41) 10511-10516; published ahead of print September 24, 2018. https://doi.org/10.1073/pnas.1808168115
Physiology
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  Cold exposure causes cell death by depolarization-mediated Ca²⁺ overload in a chill-susceptible insect
  Jeppe Seamus Bayley, Christian Bak Winther, Mads Kuhlmann Andersen, Camilla Grønkjær, Ole Bækgaard Nielsen, Thomas Holm Pedersen, and Johannes Overgaard
  
  PNAS October 9, 2018 115 (41) E9737-E9744; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1813532115
- Open Access
  Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy
  From the Cover
  
  Harry A. T. Pritchard, Paulo W. Pires, Evan Yamasaki, Pratish Thakore, and Scott Earley
  
  PNAS October 9, 2018 115 (41) E9745-E9752; published ahead of print September 4, 2018. https://doi.org/10.1073/pnas.1804593115
Plant Biology
- Open Access
  Energy-dependent quenching adjusts the excitation diffusion length to regulate photosynthetic light harvesting
  Doran I. G. Bennett, Graham R. Fleming, and Kapil Amarnath
  
  PNAS October 9, 2018 115 (41) E9523-E9531; published ahead of print September 20, 2018. https://doi.org/10.1073/pnas.1806597115
- Open Access
  Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors
  Inaugural Article
  
  Yan Ma, Hailong Guo, Lanxi Hu, Paula Pons Martinez, Panagiotis N. Moschou, Volkan Cevik, Pingtao Ding, Zane Duxbury, Panagiotis F. Sarris, and Jonathan D. G. Jones
  
  PNAS October 9, 2018 115 (41) 10218-10227; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1811858115
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  Structure of a PSI–LHCI–cyt b₆f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions
  Janina Steinbeck, Ian L. Ross, Rosalba Rothnagel, Philipp Gäbelein, Stefan Schulze, Nichole Giles, Rubbiya Ali, Rohan Drysdale, Emma Sierecki, Yann Gambin, Henning Stahlberg, Yuichiro Takahashi, Michael Hippler, and Ben Hankamer
  
  PNAS October 9, 2018 115 (41) 10517-10522; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1809973115
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  Dawn and photoperiod sensing by phytochrome A
  Daniel D. Seaton, Gabriela Toledo-Ortiz, Ashwin Ganpudi, Akane Kubota, Takato Imaizumi, and Karen J. Halliday
  
  PNAS October 9, 2018 115 (41) 10523-10528; published ahead of print September 25, 2018. https://doi.org/10.1073/pnas.1803398115

Correction (Online Only)

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Correction for Mittal et al., Codon usage influences fitness through RNA toxicity
PNAS October 9, 2018 115 (41) E9753; published ahead of print October 1, 2018. https://doi.org/10.1073/pnas.1815812115

SI Correction (Online Only)

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Correction to Supporting Information for Reid-Bayliss and Loeb, Accurate RNA consensus sequencing for high-fidelity detection of transcriptional mutagenesis-induced epimutations
PNAS October 9, 2018 115 (41) E9754; published ahead of print October 1, 2018. https://doi.org/10.1073/pnas.1815350115

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