Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Glyphosate perturbs the gut microbiota of honey bees

    Erick V. S. Motta, Kasie Raymann, and Nancy A. Moran

    PNAS October 9, 2018 115 (41) 10305-10310; first published September 24, 2018. https://doi.org/10.1073/pnas.1803880115

• Biochemistry

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    ZFAND5/ZNF216 is an activator of the 26S proteasome that stimulates overall protein degradation

    Donghoon Lee, Shinichi Takayama, and Alfred L. Goldberg

    PNAS October 9, 2018 115 (41) E9550-E9559; first published September 25, 2018. https://doi.org/10.1073/pnas.1809934115
  • Open Access

    ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB

    Hongjun Yu, Tania J. Lupoli, Amanda Kovach, Xing Meng, Gongpu Zhao, Carl F. Nathan, and Huilin Li

    PNAS October 9, 2018 115 (41) E9560-E9569; first published September 26, 2018. https://doi.org/10.1073/pnas.1810648115
  • Open Access

    Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools

    Svetlana A. Kholodar, Ananda K. Ghosh, Katarzyna Świderek, Vicent Moliner, and Amnon Kohen

    PNAS October 9, 2018 115 (41) 10311-10314; first published September 24, 2018. https://doi.org/10.1073/pnas.1811059115
  • Open Access

    Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function

    Leslie W. Glustrom, Kenneth R. Lyon, Margherita Paschini, Cynthia M. Reyes, Nicholas V. Parsonnet, Tasha B. Toro, Victoria Lundblad, and Deborah S. Wuttke

    PNAS October 9, 2018 115 (41) 10315-10320; first published September 24, 2018. https://doi.org/10.1073/pnas.1722147115

• Biophysics and Computational Biology

  • Open Access

    SAR by kinetics for drug discovery in protein misfolding diseases

    Sean Chia, Johnny Habchi, Thomas C. T. Michaels, Samuel I. A. Cohen, Sara Linse, Christopher M. Dobson, Tuomas P. J. Knowles, and Michele Vendruscolo

    PNAS October 9, 2018 115 (41) 10245-10250; first published September 26, 2018. https://doi.org/10.1073/pnas.1807884115
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    On the control of the proton current in the voltage-gated proton channel Hv1

    Myungjin Lee, Chen Bai, Mikolaj Feliks, Raphael Alhadeff, and Arieh Warshel

    PNAS October 9, 2018 115 (41) 10321-10326; first published September 25, 2018. https://doi.org/10.1073/pnas.1809766115
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    Exploring the free-energy landscape of GPCR activation

    Raphael Alhadeff, Igor Vorobyov, Han Wool Yoon, and Arieh Warshel

    PNAS October 9, 2018 115 (41) 10327-10332; first published September 26, 2018. https://doi.org/10.1073/pnas.1810316115
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    Structural titration of receptor ion channel GLIC gating by HS-AFM

    • From the Cover

    Yi Ruan, Kevin Kao, Solène Lefebvre, Arin Marchesi, Pierre-Jean Corringer, Richard K. Hite, and Simon Scheuring

    PNAS October 9, 2018 115 (41) 10333-10338; first published September 4, 2018. https://doi.org/10.1073/pnas.1805621115

    See companion article:

    • Direct visualization of ion-channel gating in a native environment

      - Sep 26, 2018
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    The interaction of talin with the cell membrane is essential for integrin activation and focal adhesion formation

    Krishna Chinthalapudi, Erumbi S. Rangarajan, and Tina Izard

    PNAS October 9, 2018 115 (41) 10339-10344; first published September 25, 2018. https://doi.org/10.1073/pnas.1806275115
  • Open Access

    Structural evidence for the roles of divalent cations in actin polymerization and activation of ATP hydrolysis

    Clement P. M. Scipion, Umesh Ghoshdastider, Fernando J. Ferrer, Tsz-Ying Yuen, Jantana Wongsantichon, and Robert C. Robinson

    PNAS October 9, 2018 115 (41) 10345-10350; first published September 25, 2018. https://doi.org/10.1073/pnas.1806394115

• Cell Biology

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    Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis

    Guan-Yu Xiao, Aparna Mohanakrishnan, and Sandra L. Schmid

    PNAS October 9, 2018 115 (41) E9570-E9579; first published September 24, 2018. https://doi.org/10.1073/pnas.1810209115
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    ERβ-mediated induction of cystatins results in suppression of TGFβ signaling and inhibition of triple-negative breast cancer metastasis

    Jordan M. Reese, Elizabeth S. Bruinsma, Adam W. Nelson, Igor Chernukhin, Jason S. Carroll, Ying Li, Malayannan Subramaniam, Vera J. Suman, Vivian Negron, David G. Monroe, James N. Ingle, Matthew P. Goetz, and John R. Hawse

    PNAS October 9, 2018 115 (41) E9580-E9589; first published September 26, 2018. https://doi.org/10.1073/pnas.1807751115
  • Open Access

    Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils

    Andreas Noack, Birthe Gericke, Maren von Köckritz-Blickwede, Arne Menze, Sandra Noack, Ingo Gerhauser, Felix Osten, Hassan Y. Naim, and Wolfgang Löscher

    PNAS October 9, 2018 115 (41) E9590-E9599; first published September 25, 2018. https://doi.org/10.1073/pnas.1719642115
  • Open Access

    BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation

    Andrew G. Li, Elizabeth C. Murphy, Aedin C. Culhane, Emily Powell, Hua Wang, Roderick T. Bronson, Thanh Von, Anita Giobbie-Hurder, Rebecca S. Gelman, Kimberly J. Briggs, Helen Piwnica-Worms, Jean J. Zhao, Andrew L. Kung, William G. Kaelin Jr., and David M. Livingston

    PNAS October 9, 2018 115 (41) E9600-E9609; first published September 25, 2018. https://doi.org/10.1073/pnas.1807112115
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    VEGF-B is a potent antioxidant

    Pachiappan Arjunan, Xianchai Lin, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Shasha Wang, Haiqing Kuang, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao, and Xuri Li

    PNAS October 9, 2018 115 (41) 10351-10356; first published September 24, 2018. https://doi.org/10.1073/pnas.1801379115
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    PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

    Laura Jamrog, Guillaume Chemin, Vincent Fregona, Lucie Coster, Marlène Pasquet, Chloé Oudinet, Nelly Rouquié, Naïs Prade, Stéphanie Lagarde, Charlotte Cresson, Sylvie Hébrard, Ngoc Sa Nguyen Huu, Marina Bousquet, Cathy Quelen, Pierre Brousset, Stéphane J. C. Mancini, Eric Delabesse, Ahmed Amine Khamlichi, Bastien Gerby, and Cyril Broccardo

    PNAS October 9, 2018 115 (41) 10357-10362; first published September 26, 2018. https://doi.org/10.1073/pnas.1721678115
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    The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation

    Tetsuya Kotani, Hiromi Kirisako, Michiko Koizumi, Yoshinori Ohsumi, and Hitoshi Nakatogawa

    PNAS October 9, 2018 115 (41) 10363-10368; first published September 25, 2018. https://doi.org/10.1073/pnas.1806727115
  • Open Access

    Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle

    Balázs Kiss, Eun-Jeong Lee, Weikang Ma, Frank W. Li, Paola Tonino, Srboljub M. Mijailovich, Thomas C. Irving, and Henk L. Granzier

    PNAS October 9, 2018 115 (41) 10369-10374; first published September 24, 2018. https://doi.org/10.1073/pnas.1804726115

• Developmental Biology

  • Open Access

    Mechanics of mouse blastocyst hatching revealed by a hydrogel-based microdeformation assay

    Karolis Leonavicius, Christophe Royer, Chris Preece, Benjamin Davies, John S. Biggins, and Shankar Srinivas

    PNAS October 9, 2018 115 (41) 10375-10380; first published September 19, 2018. https://doi.org/10.1073/pnas.1719930115
  • Open Access

    Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis

    Suk-Hyun Hong, Sungsoon Fang, Benson C. Lu, Russell Nofsinger, Yasuhiko Kawakami, Glenda L. Castro, Yunqiang Yin, Chengqi Lin, Ruth T. Yu, Michael Downes, Juan Carlos Izpisúa Belmonte, Ali Shilatifard, and Ronald M. Evans

    PNAS October 9, 2018 115 (41) 10381-10386; first published September 25, 2018. https://doi.org/10.1073/pnas.1809480115
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    Role of transcription complexes in the formation of the basal methylation pattern in early development

    Razi Greenfield, Amalia Tabib, Ilana Keshet, Joshua Moss, Ofra Sabag, Alon Goren, and Howard Cedar

    PNAS October 9, 2018 115 (41) 10387-10391; first published September 26, 2018. https://doi.org/10.1073/pnas.1804755115

• Ecology

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    Sediment starvation destroys New York City marshes’ resistance to sea level rise

    Dorothy M. Peteet, Jonathan Nichols, Timothy Kenna, Clara Chang, James Browne, Mohammad Reza, Stephen Kovari, Louisa Liberman, and Stephanie Stern-Protz

    PNAS October 9, 2018 115 (41) 10281-10286; first published September 24, 2018. https://doi.org/10.1073/pnas.1715392115
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    Contrasting dynamics and trait controls in first-order root compared with leaf litter decomposition

    Tao Sun, Sarah E. Hobbie, Björn Berg, Hongguang Zhang, Qingkui Wang, Zhengwen Wang, and Stephan Hättenschwiler

    PNAS October 9, 2018 115 (41) 10392-10397; first published September 25, 2018. https://doi.org/10.1073/pnas.1716595115

• Evolution

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    Versatility of multivalent orientation, inverted meiosis, and rescued fitness in holocentric chromosomal hybrids

    • From the Cover

    Vladimir A. Lukhtanov, Vlad Dincă, Magne Friberg, Jindra Šíchová, Martin Olofsson, Roger Vila, František Marec, and Christer Wiklund

    PNAS October 9, 2018 115 (41) E9610-E9619; first published September 28, 2018. https://doi.org/10.1073/pnas.1802610115
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    Genomic responses to selection for tame/aggressive behaviors in the silver fox (Vulpes vulpes)

    Xu Wang, Lenore Pipes, Lyudmila N. Trut, Yury Herbeck, Anastasiya V. Vladimirova, Rimma G. Gulevich, Anastasiya V. Kharlamova, Jennifer L. Johnson, Gregory M. Acland, Anna V. Kukekova, and Andrew G. Clark

    PNAS October 9, 2018 115 (41) 10398-10403; first published September 18, 2018. https://doi.org/10.1073/pnas.1800889115

• Genetics

  • Open Access

    Mutations of mitochondrial DNA are not major contributors to aging of fruit flies

    Timo E. S. Kauppila, Ana Bratic, Martin Borch Jensen, Francesca Baggio, Linda Partridge, Heinrich Jasper, Sebastian Grönke, and Nils-Göran Larsson

    PNAS October 9, 2018 115 (41) E9620-E9629; first published September 24, 2018. https://doi.org/10.1073/pnas.1721683115

• Immunology and Inflammation

  • Open Access

    Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and β1-integrin function

    Virginia Andreani, Senthilkumar Ramamoorthy, Abhinav Pandey, Ekaterina Lupar, Stephen L. Nutt, Tim Lämmermann, and Rudolf Grosschedl

    PNAS October 9, 2018 115 (41) E9630-E9639; first published September 26, 2018. https://doi.org/10.1073/pnas.1809739115
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    MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype

    Emilie Plantamura, Amiran Dzutsev, Mathias Chamaillard, Sophia Djebali, Lyvia Moudombi, Lilia Boucinha, Morgan Grau, Claire Macari, David Bauché, Oana Dumitrescu, Jean-Philippe Rasigade, Saskia Lippens, Michelina Plateroti, Elsa Kress, Annabelle Cesaro, Clovis Bondu, Ulrike Rothermel, Mathias Heikenwälder, Gerard Lina, Azzak Bentaher-Belaaouaj, Julien C. Marie, Christophe Caux, Giorgio Trinchieri, Jacqueline Marvel, and Marie-Cecile Michallet

    PNAS October 9, 2018 115 (41) 10404-10409; first published September 24, 2018. https://doi.org/10.1073/pnas.1722372115
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    Siglec-7 engagement by GBS β-protein suppresses pyroptotic cell death of natural killer cells

    Jerry J. Fong, Chih-Ming Tsai, Sudeshna Saha, Victor Nizet, Ajit Varki, and Jack D. Bui

    PNAS October 9, 2018 115 (41) 10410-10415; first published September 25, 2018. https://doi.org/10.1073/pnas.1804108115
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    Optimal protection against Salmonella infection requires noncirculating memory

    Joseph M. Benoun, Newton G. Peres, Nancy Wang, Oanh H. Pham, Victoria L. Rudisill, Zachary N. Fogassy, Paul G. Whitney, Daniel Fernandez-Ruiz, Thomas Gebhardt, Quynh-Mai Pham, Lynn Puddington, Sammy Bedoui, Richard A. Strugnell, and Stephen J. McSorley

    PNAS October 9, 2018 115 (41) 10416-10421; first published September 25, 2018. https://doi.org/10.1073/pnas.1808339115

• Medical Sciences

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    Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

    Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, and Gregg L. Semenza

    PNAS October 9, 2018 115 (41) E9640-E9648; first published September 21, 2018. https://doi.org/10.1073/pnas.1809695115

• Microbiology

  • Open Access

    Phevamine A, a small molecule that suppresses plant immune responses

    Erinn M. O’Neill, Tatiana S. Mucyn, Jon B. Patteson, Omri M. Finkel, Eui-Hwan Chung, Joshua A. Baccile, Elisabetta Massolo, Frank C. Schroeder, Jeffery L. Dangl, and Bo Li

    PNAS October 9, 2018 115 (41) E9514-E9522; first published September 20, 2018. https://doi.org/10.1073/pnas.1803779115
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    Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections

    Mario D. Garcia, Sheena M. H. Chua, Yu-Shang Low, Yu-Ting Lee, Kylie Agnew-Francis, Jian-Guo Wang, Amanda Nouwens, Thierry Lonhienne, Craig M. Williams, James A. Fraser, and Luke W. Guddat

    PNAS October 9, 2018 115 (41) E9649-E9658; first published September 24, 2018. https://doi.org/10.1073/pnas.1809422115
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    IL-15 regulates susceptibility of CD4⁺ T cells to HIV infection

    Lara Manganaro, Patrick Hong, Matthew M. Hernandez, Dionne Argyle, Lubbertus C. F. Mulder, Uma Potla, Felipe Diaz-Griffero, Benhur Lee, Ana Fernandez-Sesma, and Viviana Simon

    PNAS October 9, 2018 115 (41) E9659-E9667; first published September 26, 2018. https://doi.org/10.1073/pnas.1806695115
  • Open Access

    Genomic blueprint of a relapsing fever pathogen in 15th century Scandinavia

    Meriam Guellil, Oliver Kersten, Amine Namouchi, Egil L. Bauer, Michael Derrick, Anne Ø. Jensen, Nils C. Stenseth, and Barbara Bramanti

    PNAS October 9, 2018 115 (41) 10422-10427; first published September 24, 2018. https://doi.org/10.1073/pnas.1807266115
  • Open Access

    Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella

    Francesca Micoli, Simona Rondini, Renzo Alfini, Luisa Lanzilao, Francesca Necchi, Aurel Negrea, Omar Rossi, Cornelia Brandt, Simon Clare, Pietro Mastroeni, Rino Rappuoli, Allan Saul, and Calman A. MacLennan

    PNAS October 9, 2018 115 (41) 10428-10433; first published September 27, 2018. https://doi.org/10.1073/pnas.1807655115
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    Human Endogenous Retrovirus-K HML-2 integration within RASGRF2 is associated with intravenous drug abuse and modulates transcription in a cell-line model

    Timokratis Karamitros, Tara Hurst, Emanuele Marchi, Eirini Karamichali, Urania Georgopoulou, Andreas Mentis, Joey Riepsaame, Audrey Lin, Dimitrios Paraskevis, Angelos Hatzakis, John McLauchlan, Aris Katzourakis, and Gkikas Magiorkinis

    PNAS October 9, 2018 115 (41) 10434-10439; first published September 24, 2018. https://doi.org/10.1073/pnas.1811940115
  • Open Access

    TRIM21 mediates antibody inhibition of adenovirus-based gene delivery and vaccination

    • From the Cover

    Maria Bottermann, Stian Foss, Laurens M. van Tienen, Marina Vaysburd, James Cruickshank, Kevin O’Connell, Jessica Clark, Keith Mayes, Katie Higginson, Jack C. Hirst, Martin B. McAdam, Greg Slodkowicz, Edward Hutchinson, Patrycja Kozik, Jan Terje Andersen, and Leo C. James

    PNAS October 9, 2018 115 (41) 10440-10445; first published September 12, 2018. https://doi.org/10.1073/pnas.1806314115

    See companion article:

    • Collusion between neutralizing antibodies and other immune factions in the destruction of adenoviral vectors

      - Sep 19, 2018

• Neuroscience

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    Let-7i inhibition enhances progesterone-induced functional recovery in a mouse model of ischemia

    Trinh Nguyen, Chang Su, and Meharvan Singh

    PNAS October 9, 2018 115 (41) E9668-E9677; first published September 20, 2018. https://doi.org/10.1073/pnas.1803384115
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    FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

    Jianwen Deng, Peng Wang, Xiaoping Chen, Haipeng Cheng, Jianghong Liu, Kazuo Fushimi, Li Zhu, and Jane Y. Wu

    PNAS October 9, 2018 115 (41) E9678-E9686; first published September 24, 2018. https://doi.org/10.1073/pnas.1806655115
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    Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease

    Sarah K. Baker, Zu-Lin Chen, Erin H. Norris, Alexey S. Revenko, A. Robert MacLeod, and Sidney Strickland

    PNAS October 9, 2018 115 (41) E9687-E9696; first published September 25, 2018. https://doi.org/10.1073/pnas.1811172115
  • Open Access

    Single-molecule analysis of endogenous β-actin mRNA trafficking reveals a mechanism for compartmentalized mRNA localization in axons

    Benita Turner-Bridger, Maximillian Jakobs, Leila Muresan, Hovy Ho-Wai Wong, Kristian Franze, William A. Harris, and Christine E. Holt

    PNAS October 9, 2018 115 (41) E9697-E9706; first published September 25, 2018. https://doi.org/10.1073/pnas.1806189115
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    Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice

    Jingqi Yan, Morgan W. Porch, Brenda Court-Vazquez, Michael V. L. Bennett, and R. Suzanne Zukin

    PNAS October 9, 2018 115 (41) E9707-E9716; first published September 21, 2018. https://doi.org/10.1073/pnas.1808247115
  • Open Access

    ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins

    Hourinaz Behesti, Taylor R. Fore, Peter Wu, Zachi Horn, Mary Leppert, Court Hull, and Mary E. Hatten

    PNAS October 9, 2018 115 (41) E9717-E9726; first published September 21, 2018. https://doi.org/10.1073/pnas.1809382115
  • Open Access

    Genetically defined cellular correlates of the baseline brain MRI signal

    Jie Wen, Manu S. Goyal, Serguei V. Astafiev, Marcus E. Raichle, and Dmitriy A. Yablonskiy

    PNAS October 9, 2018 115 (41) E9727-E9736; first published September 25, 2018. https://doi.org/10.1073/pnas.1808121115
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    Neural basis of location-specific pupil luminance modulation

    Chin-An Wang and Douglas P. Munoz

    PNAS October 9, 2018 115 (41) 10446-10451; first published September 24, 2018. https://doi.org/10.1073/pnas.1809668115
  • Open Access

    Movement kinematics drive chain selection toward intention detection

    Marco Soriano, Andrea Cavallo, Alessandro D’Ausilio, Cristina Becchio, and Luciano Fadiga

    PNAS October 9, 2018 115 (41) 10452-10457; first published September 21, 2018. https://doi.org/10.1073/pnas.1809825115
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    A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

    Takato Honda, Tomoyuki Fujiyama, Chika Miyoshi, Aya Ikkyu, Noriko Hotta-Hirashima, Satomi Kanno, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, and Masashi Yanagisawa

    PNAS October 9, 2018 115 (41) 10458-10463; first published September 25, 2018. https://doi.org/10.1073/pnas.1810823115
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    Axonal plasticity associated with perceptual learning in adult macaque primary visual cortex

    Timo van Kerkoerle, Sally A. Marik, Stephan Meyer zum Alten Borgloh, and Charles D. Gilbert

    PNAS October 9, 2018 115 (41) 10464-10469; first published September 27, 2018. https://doi.org/10.1073/pnas.1812932115
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    Desert ants possess distinct memories for food and nest odors

    Roman Huber and Markus Knaden

    PNAS October 9, 2018 115 (41) 10470-10474; first published September 24, 2018. https://doi.org/10.1073/pnas.1809433115
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    Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium

    Lei Xu, Li Kong, Jiangang Wang, and John D. Ash

    PNAS October 9, 2018 115 (41) 10475-10480; first published September 24, 2018. https://doi.org/10.1073/pnas.1802724115
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    Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

    Jordi Pujols, Samuel Peña-Díaz, Diana F. Lázaro, Francesca Peccati, Francisca Pinheiro, Danilo González, Anita Carija, Susanna Navarro, María Conde-Giménez, Jesús García, Salvador Guardiola, Ernest Giralt, Xavier Salvatella, Javier Sancho, Mariona Sodupe, Tiago Fleming Outeiro, Esther Dalfó, and Salvador Ventura

    PNAS October 9, 2018 115 (41) 10481-10486; first published September 24, 2018. https://doi.org/10.1073/pnas.1804198115
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    Rapid stimulation of human dentate gyrus function with acute mild exercise

    Kazuya Suwabe, Kyeongho Byun, Kazuki Hyodo, Zachariah M. Reagh, Jared M. Roberts, Akira Matsushita, Kousaku Saotome, Genta Ochi, Takemune Fukuie, Kenji Suzuki, Yoshiyuki Sankai, Michael A. Yassa, and Hideaki Soya

    PNAS October 9, 2018 115 (41) 10487-10492; first published September 24, 2018. https://doi.org/10.1073/pnas.1805668115

    See companion article:

    • Reply to Gronwald et al.: Exercise intensity does indeed matter; maximal oxygen uptake is the gold-standard indicator

      - Dec 17, 2018
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    Striatal dopamine 2 receptor upregulation during development predisposes to diet-induced obesity by reducing energy output in mice

    Marie A. Labouesse, Andrea M. Sartori, Oliver Weinmann, Eleanor H. Simpson, Christoph Kellendonk, and Ulrike Weber-Stadlbauer

    PNAS October 9, 2018 115 (41) 10493-10498; first published September 25, 2018. https://doi.org/10.1073/pnas.1800171115
  • Open Access

    Bottom-up saliency and top-down learning in the primary visual cortex of monkeys

    Yin Yan, Li Zhaoping, and Wu Li

    PNAS October 9, 2018 115 (41) 10499-10504; first published September 25, 2018. https://doi.org/10.1073/pnas.1803854115
  • Open Access

    Functionally specific optogenetic modulation in primate visual cortex

    Mykyta M. Chernov, Robert M. Friedman, Gang Chen, Gene R. Stoner, and Anna Wang Roe

    PNAS October 9, 2018 115 (41) 10505-10510; first published September 26, 2018. https://doi.org/10.1073/pnas.1802018115

• Pharmacology

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    l-Serine–modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier

    Satoru Matsuura, Hidemasa Katsumi, Hiroe Suzuki, Natsuko Hirai, Hidetaka Hayashi, Kazuhiro Koshino, Takahiro Higuchi, Yusuke Yagi, Hiroyuki Kimura, Toshiyasu Sakane, and Akira Yamamoto

    PNAS October 9, 2018 115 (41) 10511-10516; first published September 24, 2018. https://doi.org/10.1073/pnas.1808168115

• Physiology

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    Cold exposure causes cell death by depolarization-mediated Ca²⁺ overload in a chill-susceptible insect

    Jeppe Seamus Bayley, Christian Bak Winther, Mads Kuhlmann Andersen, Camilla Grønkjær, Ole Bækgaard Nielsen, Thomas Holm Pedersen, and Johannes Overgaard

    PNAS October 9, 2018 115 (41) E9737-E9744; first published September 25, 2018. https://doi.org/10.1073/pnas.1813532115
  • Open Access

    Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy

    • From the Cover

    Harry A. T. Pritchard, Paulo W. Pires, Evan Yamasaki, Pratish Thakore, and Scott Earley

    PNAS October 9, 2018 115 (41) E9745-E9752; first published September 4, 2018. https://doi.org/10.1073/pnas.1804593115

    See companion article:

    • Ryanodine receptor cluster size sets the tone in cerebral smooth muscle

      - Sep 26, 2018

• Plant Biology

  • Open Access

    Energy-dependent quenching adjusts the excitation diffusion length to regulate photosynthetic light harvesting

    Doran I. G. Bennett, Graham R. Fleming, and Kapil Amarnath

    PNAS October 9, 2018 115 (41) E9523-E9531; first published September 20, 2018. https://doi.org/10.1073/pnas.1806597115
  • Open Access

    Distinct modes of derepression of an Arabidopsis immune receptor complex by two different bacterial effectors

    • Inaugural Article

    Yan Ma, Hailong Guo, Lanxi Hu, Paula Pons Martinez, Panagiotis N. Moschou, Volkan Cevik, Pingtao Ding, Zane Duxbury, Panagiotis F. Sarris, and Jonathan D. G. Jones

    PNAS October 9, 2018 115 (41) 10218-10227; first published September 25, 2018. https://doi.org/10.1073/pnas.1811858115

    See companion article:

    • Profile of Jonathan D. G. Jones

      - Sep 24, 2018
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    Structure of a PSI–LHCI–cyt b₆f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions

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