Proceedings of the National Academy of Sciences: 115 (43)

New Research In

October 23, 2018; vol. 115 no. 43

This Week in PNAS

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In This Issue
PNAS October 23, 2018 115 (43) 10817-10819; https://doi.org/10.1073/iti4318115

Opinion

Leading scientists discuss current issues.

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Opinion: Advocating for science progress as a human right
Front Matter
S. Porsdam Mann, Y. Donders, C. Mitchell, V. J. Bradley, M. F. Chou, M. Mann, G. Church, and H. Porsdam

PNAS October 23, 2018 115 (43) 10820-10823; https://doi.org/10.1073/pnas.1816320115

Commentaries

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Navigating genetic diversity by painting the bacteria red
Claire M. Palmer and Hal S. Alper

PNAS October 23, 2018 115 (43) 10824-10826; published ahead of print October 11, 2018. https://doi.org/10.1073/pnas.1815763115
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Stress response regulation and the hemodynamic response
Katharine Dunlop and Conor Liston

PNAS October 23, 2018 115 (43) 10827-10829; published ahead of print October 11, 2018. https://doi.org/10.1073/pnas.1814592115

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

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PNAS Plus Significance Statements
PNAS October 23, 2018 115 (43) 10830-10835; https://doi.org/10.1073/pnas.ss11543

Perspective

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Prolonging healthy aging: Longevity vitamins and proteins
Bruce N. Ames

PNAS October 23, 2018 115 (43) 10836-10844; published ahead of print October 15, 2018. https://doi.org/10.1073/pnas.1809045115

Trisections of Smooth Manifolds Special Feature (Free Online)

Introduction
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  Trisections of 4-manifolds
  From the Cover
  
  Robion Kirby
  
  PNAS October 23, 2018 115 (43) 10853-10856; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717166115
Research Articles
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  A new invariant of 4-manifolds
  Robion Kirby and Abigail Thompson
  
  PNAS October 23, 2018 115 (43) 10857-10860; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1718953115
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  Trisections of 4-manifolds with boundary
  Nickolas A. Castro, David T. Gay, and Juanita Pinzón-Caicedo
  
  PNAS October 23, 2018 115 (43) 10861-10868; published ahead of print October 22, 2018. https://doi.org/10.1073/pnas.1717170115
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  Calculating the homology and intersection form of a 4-manifold from a trisection diagram
  Peter Feller, Michael Klug, Trenton Schirmer, and Drew Zemke
  
  PNAS October 23, 2018 115 (43) 10869-10874; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717176115
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  Functoriality of group trisections
  Michael Klug
  
  PNAS October 23, 2018 115 (43) 10875-10879; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717167115
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  Bridge trisections of knotted surfaces in 4-manifolds
  Jeffrey Meier and Alexander Zupan
  
  PNAS October 23, 2018 115 (43) 10880-10886; https://doi.org/10.1073/pnas.1717171115
- You have access
  Characterizing Dehn surgeries on links via trisections
  Jeffrey Meier and Alexander Zupan
  
  PNAS October 23, 2018 115 (43) 10887-10893; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717187115
- You have access
  Simplified broken Lefschetz fibrations and trisections of 4-manifolds
  R. İnanç Baykur and Osamu Saeki
  
  PNAS October 23, 2018 115 (43) 10894-10900; published ahead of print October 22, 2018. https://doi.org/10.1073/pnas.1717175115
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  Computing trisections of 4-manifolds
  Mark Bell, Joel Hass, Joachim Hyam Rubinstein, and Stephan Tillmann
  
  PNAS October 23, 2018 115 (43) 10901-10907; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717173115
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  Generalized trisections in all dimensions
  J. Hyam Rubinstein and Stephan Tillmann
  
  PNAS October 23, 2018 115 (43) 10908-10913; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1718961115

Physical Sciences

Applied Mathematics
- Open Access
  Randomly distributed embedding making short-term high-dimensional data predictable
  Huanfei Ma, Siyang Leng, Kazuyuki Aihara, Wei Lin, and Luonan Chen
  
  PNAS October 23, 2018 115 (43) E9994-E10002; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1802987115
Applied Physical Sciences
- Open Access
  Verifying Larché–Cahn elasticity, a milestone of 20th-century thermodynamics
  Shan Shi, Jürgen Markmann, and Jörg Weissmüller
  
  PNAS October 23, 2018 115 (43) 10914-10919; published ahead of print October 5, 2018. https://doi.org/10.1073/pnas.1809355115
Chemistry
- Open Access
  Nonproteinogenic deep mutational scanning of linear and cyclic peptides
  Joseph M. Rogers, Toby Passioura, and Hiroaki Suga
  
  PNAS October 23, 2018 115 (43) 10959-10964; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1809901115
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  Protein shape modulates crowding effects
  Alex J. Guseman, Gerardo M. Perez Goncalves, Shannon L. Speer, Gregory B. Young, and Gary J. Pielak
  
  PNAS October 23, 2018 115 (43) 10965-10970; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1810054115
- Open Access
  Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles
  Assaf Gal, Andrea Sorrentino, Keren Kahil, Eva Pereiro, Damien Faivre, and André Scheffel
  
  PNAS October 23, 2018 115 (43) 11000-11005; published ahead of print October 4, 2018. https://doi.org/10.1073/pnas.1804139115
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Volatile loss following cooling and accretion of the Moon revealed by chromium isotopes
  Paolo A. Sossi, Frédéric Moynier, and Kirsten van Zuilen
  
  PNAS October 23, 2018 115 (43) 10920-10925; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1809060115
- Open Access
  Redox-dependent niche differentiation provides evidence for multiple bacterial sources of glycerol tetraether lipids in lakes
  Yuki Weber, Jaap S. Sinninghe Damsté, Jakob Zopfi, Cindy De Jonge, Adrian Gilli, Carsten J. Schubert, Fabio Lepori, Moritz F. Lehmann, and Helge Niemann
  
  PNAS October 23, 2018 115 (43) 10926-10931; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1805186115
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  Mountain snowpack response to different levels of warming
  From the Cover
  
  Laurie S. Huning and Amir AghaKouchak
  
  PNAS October 23, 2018 115 (43) 10932-10937; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1805953115
Environmental Sciences
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  Faults and associated karst collapse suggest conduits for fluid flow that influence hydraulic fracturing-induced seismicity
  Elwyn Galloway, Tyler Hauck, Hilary Corlett, Dinu Pană, and Ryan Schultz
  
  PNAS October 23, 2018 115 (43) E10003-E10012; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1807549115
Mathematics
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  A new invariant of 4-manifolds
  Robion Kirby and Abigail Thompson
  
  PNAS October 23, 2018 115 (43) 10857-10860; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1718953115
- You have access
  Trisections of 4-manifolds with boundary
  Nickolas A. Castro, David T. Gay, and Juanita Pinzón-Caicedo
  
  PNAS October 23, 2018 115 (43) 10861-10868; published ahead of print October 22, 2018. https://doi.org/10.1073/pnas.1717170115
- You have access
  Calculating the homology and intersection form of a 4-manifold from a trisection diagram
  Peter Feller, Michael Klug, Trenton Schirmer, and Drew Zemke
  
  PNAS October 23, 2018 115 (43) 10869-10874; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717176115
- You have access
  Functoriality of group trisections
  Michael Klug
  
  PNAS October 23, 2018 115 (43) 10875-10879; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717167115
- You have access
  Bridge trisections of knotted surfaces in 4-manifolds
  Jeffrey Meier and Alexander Zupan
  
  PNAS October 23, 2018 115 (43) 10880-10886; https://doi.org/10.1073/pnas.1717171115
- You have access
  Characterizing Dehn surgeries on links via trisections
  Jeffrey Meier and Alexander Zupan
  
  PNAS October 23, 2018 115 (43) 10887-10893; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717187115
- You have access
  Simplified broken Lefschetz fibrations and trisections of 4-manifolds
  R. İnanç Baykur and Osamu Saeki
  
  PNAS October 23, 2018 115 (43) 10894-10900; published ahead of print October 22, 2018. https://doi.org/10.1073/pnas.1717175115
- You have access
  Computing trisections of 4-manifolds
  Mark Bell, Joel Hass, Joachim Hyam Rubinstein, and Stephan Tillmann
  
  PNAS October 23, 2018 115 (43) 10901-10907; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1717173115
- You have access
  Generalized trisections in all dimensions
  J. Hyam Rubinstein and Stephan Tillmann
  
  PNAS October 23, 2018 115 (43) 10908-10913; published ahead of print October 23, 2018. https://doi.org/10.1073/pnas.1718961115
Physics
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  Topological quantum computation based on chiral Majorana fermions
  Biao Lian, Xiao-Qi Sun, Abolhassan Vaezi, Xiao-Liang Qi, and Shou-Cheng Zhang
  
  PNAS October 23, 2018 115 (43) 10938-10942; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1810003115
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  Machine learning determination of atomic dynamics at grain boundaries
  Tristan A. Sharp, Spencer L. Thomas, Ekin D. Cubuk, Samuel S. Schoenholz, David J. Srolovitz, and Andrea J. Liu
  
  PNAS October 23, 2018 115 (43) 10943-10947; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1807176115
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  Why large icosahedral viruses need scaffolding proteins
  Siyu Li, Polly Roy, Alex Travesset, and Roya Zandi
  
  PNAS October 23, 2018 115 (43) 10971-10976; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1807706115

Biological Sciences

Biochemistry
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  The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1
  Kirsten M. Knecht, Olga Buzovetsky, Constanze Schneider, Dominique Thomas, Vishok Srikanth, Lars Kaderali, Florentina Tofoleanu, Krystle Reiss, Nerea Ferreirós, Gerd Geisslinger, Victor S. Batista, Xiaoyun Ji, Jindrich Cinatl Jr., Oliver T. Keppler, and Yong Xiong
  
  PNAS October 23, 2018 115 (43) E10022-E10031; published ahead of print October 10, 2018. https://doi.org/10.1073/pnas.1805593115
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  Molecular mechanism of activation of the immunoregulatory amidase NAAA
  Alexei Gorelik, Ahmad Gebai, Katalin Illes, Daniele Piomelli, and Bhushan Nagar
  
  PNAS October 23, 2018 115 (43) E10032-E10040; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1811759115
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  Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase
  J. Brooks Crickard, Kyle Kaniecki, Youngho Kwon, Patrick Sung, and Eric C. Greene
  
  PNAS October 23, 2018 115 (43) E10041-E10048; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1810457115
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  Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1
  Inaugural Article
  
  Yang Li, Tian-Min Fu, Alvin Lu, Kristen Witt, Jianbin Ruan, Chen Shen, and Hao Wu
  
  PNAS October 23, 2018 115 (43) 10845-10852; published ahead of print October 2, 2018. https://doi.org/10.1073/pnas.1810524115
Biophysics and Computational Biology
- Open Access
  Randomly distributed embedding making short-term high-dimensional data predictable
  Huanfei Ma, Siyang Leng, Kazuyuki Aihara, Wei Lin, and Luonan Chen
  
  PNAS October 23, 2018 115 (43) E9994-E10002; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1802987115
- Open Access
  Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119
  Zhuo Liu, Sara Lemmonds, Juan Huang, Madhusudan Tyagi, Liang Hong, and Nitin Jain
  
  PNAS October 23, 2018 115 (43) E10049-E10058; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1807473115
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  Swi5–Sfr1 stimulates Rad51 recombinase filament assembly by modulating Rad51 dissociation
  Chih-Hao Lu, Hsin-Yi Yeh, Guan-Chin Su, Kentaro Ito, Yumiko Kurokawa, Hiroshi Iwasaki, Peter Chi, and Hung-Wen Li
  
  PNAS October 23, 2018 115 (43) E10059-E10068; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1812753115
- Open Access
  Nonproteinogenic deep mutational scanning of linear and cyclic peptides
  Joseph M. Rogers, Toby Passioura, and Hiroaki Suga
  
  PNAS October 23, 2018 115 (43) 10959-10964; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1809901115
- You have access
  Protein shape modulates crowding effects
  Alex J. Guseman, Gerardo M. Perez Goncalves, Shannon L. Speer, Gregory B. Young, and Gary J. Pielak
  
  PNAS October 23, 2018 115 (43) 10965-10970; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1810054115
- You have access
  Why large icosahedral viruses need scaffolding proteins
  Siyu Li, Polly Roy, Alex Travesset, and Roya Zandi
  
  PNAS October 23, 2018 115 (43) 10971-10976; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1807706115
Cell Biology
- Open Access
  mTOR inhibitors lower an intrinsic barrier to virus infection mediated by IFITM3
  Guoli Shi, Stosh Ozog, Bruce E. Torbett, and Alex A. Compton
  
  PNAS October 23, 2018 115 (43) E10069-E10078; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1811892115
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  Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation
  Ran Xu, Yixi Xu, Wei Huo, Zhicong Lv, Jingsong Yuan, Shaokai Ning, Qingsong Wang, Mei Hou, Ge Gao, Jianguo Ji, Junjie Chen, Rong Guo, and Dongyi Xu
  
  PNAS October 23, 2018 115 (43) E10079-E10088; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1806665115
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  XBP1s activation can globally remodel N-glycan structure distribution patterns
  Madeline Y. Wong, Kenny Chen, Aristotelis Antonopoulos, Brian T. Kasper, Mahender B. Dewal, Rebecca J. Taylor, Charles A. Whittaker, Pyae P. Hein, Anne Dell, Joseph C. Genereux, Stuart M. Haslam, Lara K. Mahal, and Matthew D. Shoulders
  
  PNAS October 23, 2018 115 (43) E10089-E10098; published ahead of print October 10, 2018. https://doi.org/10.1073/pnas.1805425115
- Open Access
  Noncanonical autophagy at ER exit sites regulates procollagen turnover
  Shakib Omari, Elena Makareeva, Anna Roberts-Pilgrim, Lynn Mirigian, Michal Jarnik, Carolyn Ott, Jennifer Lippincott-Schwartz, and Sergey Leikin
  
  PNAS October 23, 2018 115 (43) E10099-E10108; published ahead of print October 4, 2018. https://doi.org/10.1073/pnas.1814552115
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  Cryo-ET reveals the macromolecular reorganization of S. pombe mitotic chromosomes in vivo
  Shujun Cai, Chen Chen, Zhi Yang Tan, Yinyi Huang, Jian Shi, and Lu Gan
  
  PNAS October 23, 2018 115 (43) 10977-10982; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1720476115
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  SUMO protease SENP1 deSUMOylates and stabilizes c-Myc
  Xiao-Xin Sun, Yingxiao Chen, Yulong Su, Xiaoyan Wang, Krishna Mohan Chauhan, Juan Liang, Colin J. Daniel, Rosalie C. Sears, and Mu-Shui Dai
  
  PNAS October 23, 2018 115 (43) 10983-10988; published ahead of print October 10, 2018. https://doi.org/10.1073/pnas.1802932115
Ecology
- Open Access
  Changes in temperature alter the relationship between biodiversity and ecosystem functioning
  Francisca C. García, Elvire Bestion, Ruth Warfield, and Gabriel Yvon-Durocher
  
  PNAS October 23, 2018 115 (43) 10989-10994; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1805518115
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  Magnetic map in nonanadromous Atlantic salmon
  Michelle M. Scanlan, Nathan F. Putman, Amanda M. Pollock, and David L. G. Noakes
  
  PNAS October 23, 2018 115 (43) 10995-10999; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1807705115
Environmental Sciences
- Open Access
  Native-state imaging of calcifying and noncalcifying microalgae reveals similarities in their calcium storage organelles
  Assaf Gal, Andrea Sorrentino, Keren Kahil, Eva Pereiro, Damien Faivre, and André Scheffel
  
  PNAS October 23, 2018 115 (43) 11000-11005; published ahead of print October 4, 2018. https://doi.org/10.1073/pnas.1804139115
Evolution
- Open Access
  Selection and gene flow shape genomic islands that control floral guides
  Hugo Tavares, Annabel Whibley, David L. Field, Desmond Bradley, Matthew Couchman, Lucy Copsey, Joane Elleouet, Monique Burrus, Christophe Andalo, Miaomiao Li, Qun Li, Yongbiao Xue, Alexandra B. Rebocho, Nicolas H. Barton, and Enrico Coen
  
  PNAS October 23, 2018 115 (43) 11006-11011; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1801832115
- Open Access
  Whole-genome comparison of endogenous retrovirus segregation across wild and domestic host species populations
  Salvador Daniel Rivas-Carrillo, Mats E. Pettersson, Carl-Johan Rubin, and Patric Jern
  
  PNAS October 23, 2018 115 (43) 11012-11017; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1815056115
Genetics
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  Human leukemia mutations corrupt but do not abrogate GATA-2 function
  Koichi R. Katsumura, Charu Mehta, Kyle J. Hewitt, Alexandra A. Soukup, Isabela Fraga de Andrade, Erik A. Ranheim, Kirby D. Johnson, and Emery H. Bresnick
  
  PNAS October 23, 2018 115 (43) E10109-E10118; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1813015115
- Open Access
  Genetic variation in the SIM1 locus is associated with erectile dysfunction
  From the Cover
  
  Eric Jorgenson, Navneet Matharu, Melody R. Palmer, Jie Yin, Jun Shan, Thomas J. Hoffmann, Khanh K. Thai, Xujia Zhou, James M. Hotaling, Gail P. Jarvik, Nadav Ahituv, Hunter Wessells, and Stephen K. Van Den Eeden
  
  PNAS October 23, 2018 115 (43) 11018-11023; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1809872115
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  Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
  Sonia Silva, Lola P. Camino, and Andrés Aguilera
  
  PNAS October 23, 2018 115 (43) 11024-11029; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1807258115
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  Functional and evolutionary characterization of a secondary metabolite gene cluster in budding yeasts
  David J. Krause, Jacek Kominek, Dana A. Opulente, Xing-Xing Shen, Xiaofan Zhou, Quinn K. Langdon, Jeremy DeVirgilio, Amanda Beth Hulfachor, Cletus P. Kurtzman, Antonis Rokas, and Chris Todd Hittinger
  
  PNAS October 23, 2018 115 (43) 11030-11035; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1806268115
Immunology and Inflammation
- Open Access
  Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism
  Yasuharu Nagahama, Mayuko Shimoda, Guoliang Mao, Shailendra Kumar Singh, Yuuki Kozakai, Xin Sun, Daisuke Motooka, Shota Nakamura, Hiroki Tanaka, Takashi Satoh, Kazuhiko Maeda, and Shizuo Akira
  
  PNAS October 23, 2018 115 (43) 11036-11041; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1809575115
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  Glucose metabolism mediates disease tolerance in cerebral malaria
  Andrew Wang, Sarah C. Huen, Harding H. Luan, Kelly Baker, Henry Rinder, Carmen J. Booth, and Ruslan Medzhitov
  
  PNAS October 23, 2018 115 (43) 11042-11047; published ahead of print October 5, 2018. https://doi.org/10.1073/pnas.1806376115
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  Toxicity of an Fc-engineered anti-CD40 antibody is abrogated by intratumoral injection and results in durable antitumor immunity
  David A. Knorr, Rony Dahan, and Jeffrey V. Ravetch
  
  PNAS October 23, 2018 115 (43) 11048-11053; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1810566115
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  C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis
  Zaopeng Yang, Qian Li, Xin Wang, Xuepei Jiang, Dianyuan Zhao, Xin Lin, Fuchu He, and Li Tang
  
  PNAS October 23, 2018 115 (43) 11054-11059; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1804094115
Medical Sciences
- Open Access
  Differential regulation of PD-L1 expression by immune and tumor cells in NSCLC and the response to treatment with atezolizumab (anti–PD-L1)
  Marcin Kowanetz, Wei Zou, Scott N. Gettinger, Hartmut Koeppen, Mark Kockx, Peter Schmid, Edward E. Kadel III, Ignacio Wistuba, Jamie Chaft, Naiyer A. Rizvi, David R. Spigel, Alexander Spira, Fred R. Hirsch, Victor Cohen, Dustin Smith, Zach Boyd, Natasha Miley, Susan Flynn, Vincent Leveque, David S. Shames, Marcus Ballinger, Simonetta Mocci, Geetha Shankar, Roel Funke, Garret Hampton, Alan Sandler, Lukas Amler, Ira Mellman, Daniel S. Chen, and Priti S. Hegde
  
  PNAS October 23, 2018 115 (43) E10119-E10126; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1802166115
- Open Access
  iNOS promotes CD24⁺CD133⁺ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway
  Ronghua Wang, Yawen Li, Allan Tsung, Hai Huang, Qiang Du, Muqing Yang, Meihong Deng, Si Xiong, Xiju Wang, Liyong Zhang, David A. Geller, Bin Cheng, and Timothy R. Billiar
  
  PNAS October 23, 2018 115 (43) E10127-E10136; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1722100115
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  Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches
  Prosun Das, Kylee J. Veazey, Hieu T. Van, Saakshi Kaushik, Kevin Lin, Yue Lu, Masaru Ishii, Junichi Kikuta, Kai Ge, Andre Nussenzweig, and Margarida A. Santos
  
  PNAS October 23, 2018 115 (43) E10137-E10146; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1806019115
- Open Access
  Metastatic growth instructed by neutrophil-derived transferrin
  Wei Liang, Qin Li, and Napoleone Ferrara
  
  PNAS October 23, 2018 115 (43) 11060-11065; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1811717115
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  Reducing dynamin 2 (DNM2) rescues DNM2-related dominant centronuclear myopathy
  Suzie Buono, Jacob A. Ross, Hichem Tasfaout, Yotam Levy, Christine Kretz, Leighla Tayefeh, John Matson, Shuling Guo, Pascal Kessler, Brett P. Monia, Marc Bitoun, Julien Ochala, Jocelyn Laporte, and Belinda S. Cowling
  
  PNAS October 23, 2018 115 (43) 11066-11071; published ahead of print October 5, 2018. https://doi.org/10.1073/pnas.1808170115
Microbiology
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  MmpL8_MAB controls Mycobacterium abscessus virulence and production of a previously unknown glycolipid family
  Violaine Dubois, Albertus Viljoen, Laura Laencina, Vincent Le Moigne, Audrey Bernut, Faustine Dubar, Mickaël Blaise, Jean-Louis Gaillard, Yann Guérardel, Laurent Kremer, Jean-Louis Herrmann, and Fabienne Girard-Misguich
  
  PNAS October 23, 2018 115 (43) E10147-E10156; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1812984115
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  Interplay between coronavirus, a cytoplasmic RNA virus, and nonsense-mediated mRNA decay pathway
  Masami Wada, Kumari G. Lokugamage, Keisuke Nakagawa, Krishna Narayanan, and Shinji Makino
  
  PNAS October 23, 2018 115 (43) E10157-E10166; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1811675115
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  Elongation factor P is required to maintain proteome homeostasis at high growth rate
  Rodney Tollerson II, Anne Witzky, and Michael Ibba
  
  PNAS October 23, 2018 115 (43) 11072-11077; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1812025115
Neuroscience
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  Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia
  Matthew M. Nour, Tarik Dahoun, Philipp Schwartenbeck, Rick A. Adams, Thomas H. B. FitzGerald, Christopher Coello, Matthew B. Wall, Raymond J. Dolan, and Oliver D. Howes
  
  PNAS October 23, 2018 115 (43) E10167-E10176; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1809298115
- Open Access
  Activity-dependent bulk endocytosis proteome reveals a key presynaptic role for the monomeric GTPase Rab11
  A. C. Kokotos, J. Peltier, E. C. Davenport, M. Trost, and M. A. Cousin
  
  PNAS October 23, 2018 115 (43) E10177-E10186; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1809189115
- Open Access
  Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory
  Michael A. van der Kooij, Tanja Jene, Giulia Treccani, Isabelle Miederer, Annika Hasch, Nadine Voelxen, Stefan Walenta, and Marianne B. Müller
  
  PNAS October 23, 2018 115 (43) E10187-E10196; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1804412115
- Open Access
  Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function
  Bindu L. Raveendra, Supriya Swarnkar, Yosef Avchalumov, Xin-An Liu, Eddie Grinman, Kerriann Badal, Adrian Reich, Bruce D. Pascal, and Sathyanarayanan V. Puthanveettil
  
  PNAS October 23, 2018 115 (43) E10197-E10205; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1722587115
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  The brain’s hemodynamic response function rapidly changes under acute psychosocial stress in association with genetic and endocrine stress response markers
  From the Cover
  
  Immanuel G. Elbau, Benedikt Brücklmeier, Manfred Uhr, Janine Arloth, Darina Czamara, Victor I. Spoormaker, Michael Czisch, Klaas Enno Stephan, Elisabeth B. Binder, and Philipp G. Sämann
  
  PNAS October 23, 2018 115 (43) E10206-E10215; published ahead of print September 10, 2018. https://doi.org/10.1073/pnas.1804340115
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  DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members
  Andrew M. Garrett, Andre Khalil, David O. Walton, and Robert W. Burgess
  
  PNAS October 23, 2018 115 (43) E10216-E10224; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1809430115
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  MRI-based assessment of function and dysfunction in myelinated axons
  William M. Spees, Tsen-Hsuan Lin, Peng Sun, Chunyu Song, Ajit George, Sam E. Gary, Hsin-Chieh Yang, and Sheng-Kwei Song
  
  PNAS October 23, 2018 115 (43) E10225-E10234; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1801788115
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  Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs
  Erica Seigneur, Jai S. Polepalli, and Thomas C. Südhof
  
  PNAS October 23, 2018 115 (43) E10235-E10244; published ahead of print October 4, 2018. https://doi.org/10.1073/pnas.1811086115
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  Yin-and-yang bifurcation of opioidergic circuits for descending analgesia at the midbrain of the mouse
  Jong-Hyun Kim, Gireesh Gangadharan, Junweon Byun, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin
  
  PNAS October 23, 2018 115 (43) 11078-11083; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1806082115
Pharmacology
- Open Access
  p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse
  Matthew J. Robson, Meagan A. Quinlan, Kara Gross Margolis, Paula A. Gajewski-Kurdziel, Jeremy Veenstra-VanderWeele, Michael D. Gershon, D. Martin Watterson, and Randy D. Blakely
  
  PNAS October 23, 2018 115 (43) E10245-E10254; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1809137115
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  Translating biased signaling in the ghrelin receptor system into differential in vivo functions
  Franziska Mende, Cecilie Hundahl, Bianca Plouffe, Louise Julie Skov, Bjørn Sivertsen, Andreas Nygaard Madsen, Michael Lückmann, Thi Ai Diep, Stefan Offermanns, Thomas Michael Frimurer, Michel Bouvier, and Birgitte Holst
  
  PNAS October 23, 2018 115 (43) E10255-E10264; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1804003115
Plant Biology
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  Quantitative and functional posttranslational modification proteomics reveals that TREPH1 plays a role in plant touch-delayed bolting
  Kai Wang, Zhu Yang, Dongjin Qing, Feng Ren, Shichang Liu, Qingsong Zheng, Jun Liu, Weiping Zhang, Chen Dai, Madeline Wu, E. Wassim Chehab, Janet Braam, and Ning Li
  
  PNAS October 23, 2018 115 (43) E10265-E10274; published ahead of print October 5, 2018. https://doi.org/10.1073/pnas.1814006115
Psychological and Cognitive Sciences
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  Neural reactivation in parietal cortex enhances memory for episodically linked information
  Tanya R. Jonker, Halle Dimsdale-Zucker, Maureen Ritchey, Alex Clarke, and Charan Ranganath
  
  PNAS October 23, 2018 115 (43) 11084-11089; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1800006115
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  Humans incorporate attention-dependent uncertainty into perceptual decisions and confidence
  Rachel N. Denison, William T. Adler, Marisa Carrasco, and Wei Ji Ma
  
  PNAS October 23, 2018 115 (43) 11090-11095; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1717720115
Sustainability Science
- Open Access
  Bottom trawl fishing footprints on the world’s continental shelves
  Ricardo O. Amoroso, C. Roland Pitcher, Adriaan D. Rijnsdorp, Robert A. McConnaughey, Ana M. Parma, Petri Suuronen, Ole R. Eigaard, Francois Bastardie, Niels T. Hintzen, Franziska Althaus, Susan Jane Baird, Jenny Black, Lene Buhl-Mortensen, Alexander B. Campbell, Rui Catarino, Jeremy Collie, James H. Cowan Jr., Deon Durholtz, Nadia Engstrom, Tracey P. Fairweather, Heino O. Fock, Richard Ford, Patricio A. Gálvez, Hans Gerritsen, María Eva Góngora, Jessica A. González, Jan G. Hiddink, Kathryn M. Hughes, Steven S. Intelmann, Chris Jenkins, Patrik Jonsson, Paulus Kainge, Mervi Kangas, Johannes N. Kathena, Stefanos Kavadas, Rob W. Leslie, Steve G. Lewis, Mathieu Lundy, David Makin, Julie Martin, Tessa Mazor, Genoveva Gonzalez-Mirelis, Stephen J. Newman, Nadia Papadopoulou, Paulette E. Posen, Wayne Rochester, Tommaso Russo, Antonello Sala, Jayson M. Semmens, Cristina Silva, Angelo Tsolos, Bart Vanelslander, Corey B. Wakefield, Brent A. Wood, Ray Hilborn, Michel J. Kaiser, and Simon Jennings
  
  PNAS October 23, 2018 115 (43) E10275-E10282; published ahead of print October 8, 2018. https://doi.org/10.1073/pnas.1802379115
Systems Biology
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  Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow
  Elizabeth Brunk, Roger L. Chang, Jing Xia, Hooman Hefzi, James T. Yurkovich, Donghyuk Kim, Evan Buckmiller, Harris H. Wang, Byung-Kwan Cho, Chen Yang, Bernhard O. Palsson, George M. Church, and Nathan E. Lewis
  
  PNAS October 23, 2018 115 (43) 11096-11101; published ahead of print October 9, 2018. https://doi.org/10.1073/pnas.1811971115

Corrections (Online Only)

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Correction for Kneller, Franck–Condon picture of incoherent neutron scattering
PNAS October 23, 2018 115 (43) E10283; published ahead of print October 15, 2018. https://doi.org/10.1073/pnas.1816793115
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Correction for Liao et al., Metal–insulator-transition engineering by modulation tilt-control in perovskite nickelates for room temperature optical switching
PNAS October 23, 2018 115 (43) E10284; published ahead of print October 15, 2018. https://doi.org/10.1073/pnas.1816794115
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Correction for Baldwin and Mussweiler, The culture of social comparison
PNAS October 23, 2018 115 (43) E10285; published ahead of print October 15, 2018. https://doi.org/10.1073/pnas.1816586115
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Correction for Li et al., Mutually inhibitory Ras-PI(3,4)P₂ feedback loops mediate cell migration
PNAS October 23, 2018 115 (43) E10286; published ahead of print October 15, 2018. https://doi.org/10.1073/pnas.1816155115

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