Table of Contents

Biological Sciences

• Anthropology

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    An abundance of developmental anomalies and abnormalities in Pleistocene people

    Erik Trinkaus

    PNAS November 20, 2018 115 (47) 11941-11946; first published November 5, 2018. https://doi.org/10.1073/pnas.1814989115

• Applied Biological Sciences

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    Engineering the protein secretory pathway of Saccharomyces cerevisiae enables improved protein production

    Mingtao Huang, Guokun Wang, Jiufu Qin, Dina Petranovic, and Jens Nielsen

    PNAS November 20, 2018 115 (47) E11025-E11032; first published November 5, 2018. https://doi.org/10.1073/pnas.1809921115

• Biochemistry

  • Open Access

    Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex

    Alexandre Berthier, Manjula Vinod, Geoffrey Porez, Agata Steenackers, Jérémy Alexandre, Nao Yamakawa, Céline Gheeraert, Maheul Ploton, Xavier Maréchal, Julie Dubois-Chevalier, Agnès Hovasse, Christine Schaeffer-Reiss, Sarah Cianférani, Christian Rolando, Fabrice Bray, Hélène Duez, Jérôme Eeckhoute, Tony Lefebvre, Bart Staels, and Philippe Lefebvre

    PNAS November 20, 2018 115 (47) E11033-E11042; first published November 5, 2018. https://doi.org/10.1073/pnas.1805397115
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    Deciphering the structure of the condensin protein complex

    Dana Krepel, Ryan R. Cheng, Michele Di Pierro, and José N. Onuchic

    PNAS November 20, 2018 115 (47) 11911-11916; first published November 1, 2018. https://doi.org/10.1073/pnas.1812770115
  • Open Access

    Optimal molecular crowding accelerates group II intron folding and maximizes catalysis

    Bishnu P. Paudel, Erica Fiorini, Richard Börner, Roland K. O. Sigel, and David S. Rueda

    PNAS November 20, 2018 115 (47) 11917-11922; first published November 5, 2018. https://doi.org/10.1073/pnas.1806685115
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    Crystal structure of heme A synthase from Bacillus subtilis

    Satomi Niwa, Kazuki Takeda, Masayuki Kosugi, Erika Tsutsumi, Tatsushi Mogi, and Kunio Miki

    PNAS November 20, 2018 115 (47) 11953-11957; first published November 5, 2018. https://doi.org/10.1073/pnas.1813346115
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    Crystal structure of human mARC1 reveals its exceptional position among eukaryotic molybdenum enzymes

    Christian Kubitza, Florian Bittner, Carsten Ginsel, Antje Havemeyer, Bernd Clement, and Axel J. Scheidig

    PNAS November 20, 2018 115 (47) 11958-11963; first published November 5, 2018. https://doi.org/10.1073/pnas.1808576115

• Biophysics and Computational Biology

  • Open Access

    Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics

    Haoran Yu and Paul A. Dalby

    PNAS November 20, 2018 115 (47) E11043-E11052; first published November 7, 2018. https://doi.org/10.1073/pnas.1810324115

    See companion article:

    • Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off

      - Dec 10, 2018
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    Highly disordered histone H1−DNA model complexes and their condensates

    • From the Cover

    Abigail L. Turner, Matthew Watson, Oscar G. Wilkins, Laura Cato, Andrew Travers, Jean O. Thomas, and Katherine Stott

    PNAS November 20, 2018 115 (47) 11964-11969; first published October 9, 2018. https://doi.org/10.1073/pnas.1805943115

    See companion article:

    • Linker histones as liquid-like glue for chromatin

      - Nov 02, 2018
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    Allosteric landscapes of eukaryotic cytoplasmic Hsp70s are shaped by evolutionary tuning of key interfaces

    Wenli Meng, Eugenia M. Clerico, Natalie McArthur, and Lila M. Gierasch

    PNAS November 20, 2018 115 (47) 11970-11975; first published November 5, 2018. https://doi.org/10.1073/pnas.1811105115
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    Self-cleavage of the glmS ribozyme core is controlled by a fragile folding element

    Andrew Savinov and Steven M. Block

    PNAS November 20, 2018 115 (47) 11976-11981; first published November 5, 2018. https://doi.org/10.1073/pnas.1812122115

• Cell Biology

  • Open Access

    Evolution of weak cooperative interactions for biological specificity

    Ang Gao, Krishna Shrinivas, Paul Lepeudry, Hiroshi I. Suzuki, Phillip A. Sharp, and Arup K. Chakraborty

    PNAS November 20, 2018 115 (47) E11053-E11060; first published November 7, 2018. https://doi.org/10.1073/pnas.1815912115

• Developmental Biology

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    Polypyrimidine tract-binding protein blocks miRNA-124 biogenesis to enforce its neuronal-specific expression in the mouse

    Kyu-Hyeon Yeom, Simon Mitchell, Anthony J. Linares, Sika Zheng, Chia-Ho Lin, Xiao-Jun Wang, Alexander Hoffmann, and Douglas L. Black

    PNAS November 20, 2018 115 (47) E11061-E11070; first published November 6, 2018. https://doi.org/10.1073/pnas.1809609115
  • Open Access

    Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning

    Dawei Yu, Jing Wang, Huiying Zou, Tao Feng, Lei Chen, Jia Li, Xiaolan Qi, Zhifang Li, Xiaoyue Duan, Chunlong Xu, Liang Zhang, Xi Long, Jing Lan, Chao Chen, Chao Wang, Xinyu Xu, Jilong Ren, Yiqiang Zhao, Xiaoxiang Hu, Zhengxing Lian, Hongsheng Men, Dengke Pan, Ning Li, Mario R. Capecchi, Xuguang Du, Yaofeng Zhao, and Sen Wu

    PNAS November 20, 2018 115 (47) E11071-E11080; first published October 31, 2018. https://doi.org/10.1073/pnas.1814514115

• Ecology

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    Climate change causes upslope shifts and mountaintop extirpations in a tropical bird community

    • From the Cover

    Benjamin G. Freeman, Micah N. Scholer, Viviana Ruiz-Gutierrez, and John W. Fitzpatrick

    PNAS November 20, 2018 115 (47) 11982-11987; first published October 29, 2018. https://doi.org/10.1073/pnas.1804224115

    See companion article:

    • Escalator to extinction

      - Nov 05, 2018
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    Habitat choice meets thermal specialization: Competition with specialists may drive suboptimal habitat preferences in generalists

    Staffan Jacob, Estelle Laurent, Bart Haegeman, Romain Bertrand, Jérôme G. Prunier, Delphine Legrand, Julien Cote, Alexis S. Chaine, Michel Loreau, Jean Clobert, and Nicolas Schtickzelle

    PNAS November 20, 2018 115 (47) 11988-11993; first published November 5, 2018. https://doi.org/10.1073/pnas.1805574115
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    Decomposition responses to climate depend on microbial community composition

    Sydney I. Glassman, Claudia Weihe, Junhui Li, Michaeline B. N. Albright, Caitlin I. Looby, Adam C. Martiny, Kathleen K. Treseder, Steven D. Allison, and Jennifer B. H. Martiny

    PNAS November 20, 2018 115 (47) 11994-11999; first published November 5, 2018. https://doi.org/10.1073/pnas.1811269115

• Evolution

  • Open Access

    Behavior-dependent cis regulation reveals genes and pathways associated with bower building in cichlid fishes

    Ryan A. York, Chinar Patil, Kawther Abdilleh, Zachary V. Johnson, Matthew A. Conte, Martin J. Genner, Patrick T. McGrath, Hunter B. Fraser, Russell D. Fernald, and J. Todd Streelman

    PNAS November 20, 2018 115 (47) E11081-E11090; first published November 5, 2018. https://doi.org/10.1073/pnas.1810140115
  • Open Access

    Evolution of bidirectional costly mutualism from byproduct consumption

    • From the Cover

    William R. Harcombe, Jeremy M. Chacón, Elizabeth M. Adamowicz, Lon M. Chubiz, and Christopher J. Marx

    PNAS November 20, 2018 115 (47) 12000-12004; first published October 22, 2018. https://doi.org/10.1073/pnas.1810949115

    See companion article:

    • Evolution of bacterial trade in a two-species community

      - Nov 12, 2018
  • Open Access

    Unique pelvic fin in a tetrapod-like fossil fish, and the evolution of limb patterning

    Jonathan E. Jeffery, Glenn W. Storrs, Timothy Holland, Clifford J. Tabin, and Per E. Ahlberg

    PNAS November 20, 2018 115 (47) 12005-12010; first published November 5, 2018. https://doi.org/10.1073/pnas.1810845115
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    Inclusive fitness consequences of dispersal decisions in a cooperatively breeding bird, the long-tailed tit (Aegithalos caudatus)

    Jonathan P. Green and Ben J. Hatchwell

    PNAS November 20, 2018 115 (47) 12011-12016; first published November 5, 2018. https://doi.org/10.1073/pnas.1815873115
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    The geographic mosaic of coevolution in mutualistic networks

    Lucas P. Medeiros, Guilherme Garcia, John N. Thompson, and Paulo R. Guimarães Jr.

    PNAS November 20, 2018 115 (47) 12017-12022; first published November 7, 2018. https://doi.org/10.1073/pnas.1809088115

• Genetics

  • Open Access

    Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats

    Louise Y. Fong, Ruiyan Jing, Karl J. Smalley, Zi-Xuan Wang, Cristian Taccioli, Sili Fan, Hongping Chen, Hansjuerg Alder, Kay Huebner, John L. Farber, Oliver Fiehn, and Carlo M. Croce

    PNAS November 20, 2018 115 (47) E11091-E11100; first published November 5, 2018. https://doi.org/10.1073/pnas.1813956115
  • Open Access

    Criticality in tumor evolution and clinical outcome

    Erez Persi, Yuri I. Wolf, Mark D. M. Leiserson, Eugene V. Koonin, and Eytan Ruppin

    PNAS November 20, 2018 115 (47) E11101-E11110; first published November 7, 2018. https://doi.org/10.1073/pnas.1807256115

• Immunology and Inflammation

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    Protective immunity in recurrent Staphylococcus aureus infection reflects localized immune signatures and macrophage-conferred memory

    • From the Cover

    Liana C. Chan, Maura Rossetti, Lloyd S. Miller, Scott G. Filler, Colin W. Johnson, Hong K. Lee, Huiyuan Wang, David Gjertson, Vance G. Fowler Jr., Elaine F. Reed, Michael R. Yeaman, and the MRSA Systems Immunobiology Group

    PNAS November 20, 2018 115 (47) E11111-E11119; first published October 8, 2018. https://doi.org/10.1073/pnas.1808353115

    See companion article:

    • Macrophages and innate immune memory against Staphylococcus skin infections

      - Nov 02, 2018
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    Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody

    John P. Giddens, Joseph V. Lomino, David J. DiLillo, Jeffrey V. Ravetch, and Lai-Xi Wang

    PNAS November 20, 2018 115 (47) 12023-12027; first published November 5, 2018. https://doi.org/10.1073/pnas.1812833115

• Medical Sciences

  • Open Access

    A flexible organic reflectance oximeter array

    Yasser Khan, Donggeon Han, Adrien Pierre, Jonathan Ting, Xingchun Wang, Claire M. Lochner, Gianluca Bovo, Nir Yaacobi-Gross, Chris Newsome, Richard Wilson, and Ana C. Arias

    PNAS November 20, 2018 115 (47) E11015-E11024; first published November 7, 2018. https://doi.org/10.1073/pnas.1813053115
  • Open Access

    Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

    Tamara L. Lenis, Jane Hu, Sze Yin Ng, Zhichun Jiang, Shanta Sarfare, Marcia B. Lloyd, Nicholas J. Esposito, William Samuel, Cynthia Jaworski, Dean Bok, Silvia C. Finnemann, Monte J. Radeke, T. Michael Redmond, Gabriel H. Travis, and Roxana A. Radu

    PNAS November 20, 2018 115 (47) E11120-E11127; first published November 5, 2018. https://doi.org/10.1073/pnas.1802519115
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    Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism

    Huensuk Kim, Seungyeul Yoo, Ruoji Zhou, An Xu, Jeffrey M. Bernitz, Ye Yuan, Andreia M. Gomes, Michael G. Daniel, Jie Su, Elizabeth G. Demicco, Jun Zhu, Kateri A. Moore, Dung-Fang Lee, Ihor R. Lemischka, and Christoph Schaniel

    PNAS November 20, 2018 115 (47) E11128-E11137; first published November 1, 2018. https://doi.org/10.1073/pnas.1814044115
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    Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification

    N. Sanjib Banerjee, Dianne W. Moore, Thomas R. Broker, and Louise T. Chow

    PNAS November 20, 2018 115 (47) E11138-E11147; first published November 1, 2018. https://doi.org/10.1073/pnas.1801156115
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    Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH

    Andrew V. Schally, Haibo Wang, Jinlin He, Renzhi Cai, Wei Sha, Petra Popovics, Roberto Perez, Irving Vidaurre, and Xianyang Zhang

    PNAS November 20, 2018 115 (47) 12028-12033; first published October 29, 2018. https://doi.org/10.1073/pnas.1813375115

    See companion article:

    • Inhibition of tumor growth by agonists of growth hormone-releasing hormone

      - Nov 07, 2018
  • Open Access

    NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death

    Yuxuan Liu, Patrizia Mondello, Tatiana Erazo, Neeta Bala Tannan, Zahra Asgari, Elisa de Stanchina, Gouri Nanjangud, Venkatraman E. Seshan, Shenqiu Wang, Hans-Guido Wendel, and Anas Younes

    PNAS November 20, 2018 115 (47) 12034-12039; first published November 7, 2018. https://doi.org/10.1073/pnas.1806928115

• Microbiology

  • Open Access

    Evolution of drug resistance in an antifungal-naive chronic Candida lusitaniae infection

    Elora G. Demers, Amy R. Biermann, Sawyer Masonjones, Alex W. Crocker, Alix Ashare, Jason E. Stajich, and Deborah A. Hogan

    PNAS November 20, 2018 115 (47) 12040-12045; first published November 2, 2018. https://doi.org/10.1073/pnas.1807698115

• Neuroscience

  • Open Access

    Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

    Karolina J. Janczura, Claude-Henry Volmar, Gregory C. Sartor, Sunil J. Rao, Natalie R. Ricciardi, Guerline Lambert, Shaun P. Brothers, and Claes Wahlestedt

    PNAS November 20, 2018 115 (47) E11148-E11157; first published November 5, 2018. https://doi.org/10.1073/pnas.1805436115
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    Face cells in orbitofrontal cortex represent social categories

    Elodie Barat, Sylvia Wirth, and Jean-René Duhamel

    PNAS November 20, 2018 115 (47) E11158-E11167; first published November 5, 2018. https://doi.org/10.1073/pnas.1806165115
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    Autocrine signaling by an Aplysia neurotrophin forms a presynaptic positive feedback loop

    Iksung Jin, Hiroshi Udo, Russell Nicholls, Huixiang Zhu, Eric R. Kandel, and Robert D. Hawkins

    PNAS November 20, 2018 115 (47) E11168-E11177; first published November 5, 2018. https://doi.org/10.1073/pnas.1810649115

    See companion article:

    • Anterograde and retrograde signaling by an Aplysia neurotrophin forms a transsynaptic functional unit

      - Oct 30, 2018
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    Awareness of what is learned as a characteristic of hippocampus-dependent memory

    Christine N. Smith and Larry R. Squire

    PNAS November 20, 2018 115 (47) 11947-11952; first published November 5, 2018. https://doi.org/10.1073/pnas.1814843115

• Pharmacology

  • Open Access

    Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists

    Hongtao Liu, Josefa Hofmann, Inbar Fish, Benjamin Schaake, Katrin Eitel, Amelie Bartuschat, Jonas Kaindl, Hannelore Rampp, Ashutosh Banerjee, Harald Hübner, Mary J. Clark, Sandra G. Vincent, John T. Fisher, Markus R. Heinrich, Kunio Hirata, Xiangyu Liu, Roger K. Sunahara, Brian K. Shoichet, Brian K. Kobilka, and Peter Gmeiner

    PNAS November 20, 2018 115 (47) 12046-12050; first published November 7, 2018. https://doi.org/10.1073/pnas.1813988115

• Physiology

  • Open Access

    Engineering selectivity into RGK GTPase inhibition of voltage-dependent calcium channels

    Akil A. Puckerin, Donald D. Chang, Zunaira Shuja, Papiya Choudhury, Joachim Scholz, and Henry M. Colecraft

    PNAS November 20, 2018 115 (47) 12051-12056; first published November 5, 2018. https://doi.org/10.1073/pnas.1811024115

• Plant Biology

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    Arabidopsis thaliana NGATHA1 transcription factor induces ABA biosynthesis by activating NCED3 gene during dehydration stress

    Hikaru Sato, Hironori Takasaki, Fuminori Takahashi, Takamasa Suzuki, Satoshi Iuchi, Nobutaka Mitsuda, Masaru Ohme-Takagi, Miho Ikeda, Mitsunori Seo, Kazuko Yamaguchi-Shinozaki, and Kazuo Shinozaki

    PNAS November 20, 2018 115 (47) E11178-E11187; first published November 5, 2018. https://doi.org/10.1073/pnas.1811491115
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    Flavonols control pollen tube growth and integrity by regulating ROS homeostasis during high-temperature stress

    • From the Cover

    Joëlle K. Muhlemann, Trenton L. B. Younts, and Gloria K. Muday

    PNAS November 20, 2018 115 (47) E11188-E11197; first published November 9, 2018. https://doi.org/10.1073/pnas.1811492115
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    C₄ photosynthesis and climate through the lens of optimality

    Haoran Zhou, Brent R. Helliker, Matthew Huber, Ashley Dicks, and Erol Akçay

    PNAS November 20, 2018 115 (47) 12057-12062; first published November 6, 2018. https://doi.org/10.1073/pnas.1718988115

• Psychological and Cognitive Sciences

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    Functional connectivity in central executive network protects youth against cardiometabolic risks linked with neighborhood violence

    Gregory E. Miller, Edith Chen, Casey C. Armstrong, Ann L. Carroll, Sekine Ozturk, Kelsey J. Rydland, Gene H. Brody, Todd B. Parrish, and Robin Nusslock

    PNAS November 20, 2018 115 (47) 12063-12068; first published November 5, 2018. https://doi.org/10.1073/pnas.1810067115

• Sustainability Science

  • Open Access

    A multiscale approach to balance trade-offs among dam infrastructure, river restoration, and cost

    Samuel G. Roy, Emi Uchida, Simone P. de Souza, Ben Blachly, Emma Fox, Kevin Gardner, Arthur J. Gold, Jessica Jansujwicz, Sharon Klein, Bridie McGreavy, Weiwei Mo, Sean M. C. Smith, Emily Vogler, Karen Wilson, Joseph Zydlewski, and David Hart

    PNAS November 20, 2018 115 (47) 12069-12074; first published November 5, 2018. https://doi.org/10.1073/pnas.1807437115