Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers

Edited by Francisco M. Salzano, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, and approved October 5, 2018 (received for review July 13, 2018)

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vol. 115 no. 48 E11256-E11263

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^aDepartment of Anthropology, Pennsylvania State University, University Park, PA 16802;
^bDepartment of Biology, Pennsylvania State University, University Park, PA 16802;
^cUnit of Human Evolutionary Genetics, Institut Pasteur, 75015 Paris, France;
^dGénomique Évolutive, Modélisation et Santé (UMR 2000), Centre National de la Recherche Scientifique, 75015 Paris, France;
^eCenter of Bioinformatics, Biostatistics and Integrative Biology, Institut Pasteur, 75015 Paris, France;
^fCentre de Recherche Centre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montréal, Montréal, QC H3T 1C5, Canada;
^gHuck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802

Edited by Francisco M. Salzano, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil, and approved October 5, 2018 (received for review July 13, 2018)

↵¹To whom correspondence may be addressed. Email: cxb585{at}psu.edu or ghp3{at}psu.edu.
↵²L.Q.-M., L.B.B., and G.H.P. contributed equally to this work.

Author contributions: C.M.B., L.Q.-M., L.B.B., and G.H.P. designed research; C.M.B., M.L., G.F.H., E.P., and J.A.C. performed research; C.M.B., M.L., G.F.H., and E.P. analyzed data; and C.M.B. and G.H.P. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
Data deposition: Exome data for the Batwa and Bakiga populations have been deposited in the European Genome–Phenome Archive (EGA), https://ega-archive.org/ (accession no. EGAS00001002457). All scripts used in the analysis are available on GitHub (https://github.com/bergeycm/rhg-convergence-analysis).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1812135115/-/DCSupplemental.